sdqs – standardized drug queries
TRANSCRIPT
![Page 1: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/1.jpg)
SDQs – Standardized Drug
Queries
Daniel von Sydow
Sunil G. Singh
![Page 2: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/2.jpg)
Outline
• The project
• Background
• Current analysis tools
• Ideas for future development
2
![Page 3: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/3.jpg)
Under development
• A working group has been set up with members from the industry
• The group is identifying ‘prototype’ queries
• The content, distribution format and versioning are also being discussed
• The ‘prototype’ queries will be launched to the pilot group in March 2009
• First ‘official’ SDQs launched in March 2010
3
![Page 4: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/4.jpg)
Background
• WHO Drug Dictionary Enhanced is used for coding and analysis.
– The coder selects anentry
– Code entered into database
– Codes and hierarchies are used for
aggregation and statistical analysis
4
![Page 5: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/5.jpg)
Background
• What is analyzed?
– Interactions
– ADRs
– Drug effectiveness
– Protocol violations
– Other conditions
5
![Page 6: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/6.jpg)
Current analysis tools
• Drug code
– Useful to aggregate drugs with the same
ingredient(s)
• ATC/Herbal ATC.
– Useful mainly for statistical analysis
– Also useful to make pharmacological/Medical
analysis
6
![Page 7: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/7.jpg)
New ideas
• Other needs
– Sometimes aggregation of statistics could use
other groupings than ATC.
– Statistical analysis is often followed by
medical analysis – what is the mechanism
behind an interaction?
– Sometimes a list of “Drugs of Special interest”
is used in a trial.
7
![Page 8: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/8.jpg)
Pharmacological classes
• The SDQs could be a pharmacological class; NSAIDs, Colinergic drugs and Steroids
• These groups appears in several places in the ATC hierarchy depending on therapeutic use
8
![Page 9: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/9.jpg)
Metabolism
• The SDQs could list drugs that are metabolized by certain enzymes.
– Example: Substrates, inducers and inhibitors of CYP 2C19
• This could be used to explain interactions, increased effect or lack of effect.
• The SDQs can be used to produce lists of “drugs of special interest”.
9
![Page 10: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/10.jpg)
Conditions
• The SDQs could list drugs that are likely to be ‘proxy for conditions”.
• Sometimes medical conditions are not reported as such, but medication taken by patients may indicate that conditions exists
10
![Page 11: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/11.jpg)
Implementing SDQs in TMS 4.6
• Current Filter dictionary approach can be used, with the same type of Informative Notes for Description and Source.
• Concept of hierarchical SMQs is also possible
• Similar Algorithm Informative notes can also be used for identifying related terms.
11
![Page 12: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/12.jpg)
[X] SDQ Filter Dictionary
Definition
12
![Page 13: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/13.jpg)
[X] SDQ Domain Mapping
13
![Page 14: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/14.jpg)
[X] SDQ NRLs: Substrates,
Inhibitors, Inducers
14
![Page 15: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/15.jpg)
[X] SDQ Activation Group
15
![Page 16: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/16.jpg)
[X] SDQ Repository Authoring
16
![Page 17: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/17.jpg)
[X] SDQ CYP3A4 Lite Browser
17
![Page 18: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/18.jpg)
[X] SDQ Relations Lite Browser
18
![Page 19: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/19.jpg)
[X] VT Coding for SDQ
19
![Page 20: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/20.jpg)
[X] VT Coding for SDQ (2)
20
![Page 21: SDQs – Standardized Drug Queries](https://reader035.vdocuments.us/reader035/viewer/2022071602/613d6b42736caf36b75d1b42/html5/thumbnails/21.jpg)
Conclusion
• SDQs will be a new tool for WHO Drug Dictionary Enhanced users
• The SDQs can be used for:– statistical analysis – e.g. finding patterns using
pharmacological classes
– medical analysis – e.g. finding mechanism based on metabolism information
– finding protocol violations – e.g. if NSAIDs are a prohibited class of drugs
– finding otherwise unreported condition
21