scientists creating synthetic organism b9802095 kevin sheu ( 許傑 ) 醫學二
TRANSCRIPT
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Scientists creating synthetic organism
B9802095 Kevin Sheu (許傑 )醫學二
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VocabularyintroductionSupplements
discussion
Outline
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Vocabulary
• Piecemeal 逐漸的• Menagerie 動物展• Anew 重新• Play down 貶低• Patent 專利• Moratorium 暫停 ; 中止
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Vocabulary
• Mandate 命令• Culmination 巔峰• Consortium 財團• Customize 訂做• Meld 融合• Watermark 水印
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Scientists have created a synthetic cell, completely controlled by man-made genetic instructions.
The development may stir anew nagging questions of ethics, law and public safety.
It has the potential to transform genetic engineering.
First part
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Some researchers chose neutral terms to describe the experimental cell. Some play down the development.
Some view this as an organism with a synthetic genome, not as a synthetic organism.
Second part
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Several companies are already seeking to take advantage of the new field called synthetic biology.
Environment groups issued a statement “regulate all synthetic biology experiments and products”
There was no immediate reaction from Roman Catholic and protestant groups.
Third part
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Wrote out the DNA code Revise the sequence Synthesize small fragments Connect the strips Inject the connected DNA into the genome-
removed cell
Introduction of DNA synthesis
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Introduction of shotgun sequencing
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(from Mycoplasma capricolum’DNA and M. capricolum’s cell, which lives in ruminants causing lung disease.)
Mycoplasma mycoides JCVI-syn1.0
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James Joyce:生存、犯錯、倒下、戰勝,用生命創造生命
J. Robert Oppenheimer:觀看事物潛能而非表象 Richard Feynman:我無法創造的,我無法了解
Watermarks in JCVI-syn1.0
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Human genome project Celera Genomics corp. Kistler Prize ENI award
J. Craig Venter
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Artificially synthesized polymer similar to DNA or RNA
PNA's backbone is composed of repeating N-(2-aminoethyl)-glycine units linked by peptide bonds.
Purine and pyrimidine bases are linked to the backbone by methylene carbonyl bonds.
Usage: diagnostic assays and antisense therapies Earliest life on Earth may have used PNA as a
genetic material
Peptide Nucleic Acid (PNA-肽核酸 )
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1. Will you back up this technique or are against it?
2. What kind of problem might happen if this technique matures?
Discussion