scientific discoveries and translational research · 2017-08-23 · email: [email protected]...

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Drug Discovery

Acute Brain ImpairmentScientific Discoveries and Translational Research

Edited by Philip Peplow, Svetlana Dambinova, Thomas A. Gennarelli and Bridget Martinez

Advance Book Information January 2018

All information is subject to change without notice

Acute Brain ImpairmentScientific Discoveries and Translational Research

Philip Peplow University of Otago, New Zealand Svetlana Dambinova Kennesaw State University Thomas A Gennarelli George Washington University, USA Bridget Martinez University of California, Merced, USA

SynopsisA rise in the number of young and old patients with stroke has led to the need for better drug development and treatment, as well as diagnosis and prevention for ischemic stroke and mild traumatic brain injury. This book provides a comprehensive overview of advancements in the development of neuroprotective drugs, chemical biomarkers for detection, imaging and preventative strategies. This book will be useful to postgraduate students and researchers in medicinal chemistry and pharmacology as well as specialists in the acute brain injury field.

Brief Contents

Series: Drug Discovery

ISSN: 2041-3203

Publisher: Royal Society of Chemistry

ISBN: 9781782629504

Price: £149.00 | $245.00

Publishing date: 01/01/2018

Target Audience: Professional and scholarly

Format: Hardback

Size: 234 x 156

Pages: 300

BIC: PSB, PSD, PSF

TIA, TBI and ischemic stroke, and risk factors

Inflammatory changes in cerebral ischemic injury:

cellular and molecular involvement

Biomarkers of acute brain injury and surrogate endpoints in TBI and stroke

translational studies

Difficulties of translating outcomes from animal studies to clinical trials

Neuroprotective therapies for ischemic stroke

The molecular strategies in cerebral ischemia: An insight into emerging

treatment for oxidative stress

Identification of microRNAs as targets for treatment of ischemic stroke

Edition: 1

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Green Chemistry Series

Catalyst-free Organic Synthesis

Goutam Brahmachari



Catalyst-free Organic SynthesisGoutam Brahmachari Visva-Bharati University, India

SynopsisExplaining methods for carrying out chemical syntheses without the use of catalysts, this book shows how avoiding catalysts during synthesis can mean less use of toxic chemicals, environmentally damaging chemicals, or endangered elements, and lower costs. It is an important reference for chemists involved in organic synthesis, as well as for green chemists.

Brief Contents

Series: Green Chemistry Series

ISSN: 1757-7039


ISBN: 9781782624127

Price: £149.00 | $245.00



Format: Hardback

Size: 234 x 156

Pages: 300

BIC: PNN, RNU

Catalyst-free Organic Synthesis: An Introduction

Catalyst-free Organic Reactions under Room Temperature Conditions

Catalyst-free Organic Reactions under Conventional Heating

Catalyst-free Organic Reactions under Microwave Irradiation

Catalyst-free Organic Reactions under Ultrasound Irradiation

Catalyst-free Organic Reactions under Ball-MillingEdition: 1

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Bio

catalysis in O

rgan

ic Synth

esisT

he R

etrosyn

thesis A

pp

roach

Turn

er & H

um

ph

reys

Biocatalysis in Organic SynthesisThe Retrosynthesis ApproachNicholas J. Turner and Luke Humphreys



Biocatalysis in Organic SynthesisThe Retrosynthesis ApproachNicholas J Turner University of Manchester, UK Luke Humphreys GlaxoSmithKline, UK

SynopsisThis unique textbook provides new guidelines for “biocatalytic retrosynthesis” in which molecules are disconnected with consideration for applying biocatalysts in the forward synthesis direction. It aims to enable students to make the connection between biocatalysis and synthesis earlier in their studies and to equip students for the modern world of organic synthesis where biocatalysts play an increasingly important role. Tutorials enable the reader to practise disconnecting target molecules to find the ‘hidden’ biocatalytic reactions which can be applied in the synthetic direction. It also contains a complete description of the current biocatalyst classes that are available. This textbook is an essential resource for lecturers and students studying synthetic chemistry. It also serves as a handy reference for practising chemists wishing to embed biocatalysis into their synthetic toolbox.

Brief Contents

Series: Not Applicable

ISSN: Not Applicable


ISBN: 9781782625308

Price: £49.99 | $77.99


Target Audience: College/higher education

Format: Paperback

Size: 234 x 156

Pages: 300

BIC: PNN, PNRD, TCB

Biocatalysis basics and principles

Hydrolysis

Reverse hydrolysis

Reduction

Oxidation

C-X bond formation

C-C bond formation

Miscellaneous biocatalysts

Acrylic systems

4-,5-,6-,7- membered carbocyclic rings

Edition: 1

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Green Chemistry Series

Hazardous Reagent SubstitutionA Pharmaceutical Perspective

Edited by R. K. Sharma andRakeshwar Bandichhor



Hazardous Reagent SubstitutionA Pharmaceutical PerspectiveRakesh Kumar Sharma University of Delhi, India Rakeshwar Bandichhor Dr Reddy's Laboratories Ltd, India

SynopsisPresenting examples of drugs and their synthesis via green chemistry routes, this book shows how the pharmaceutical industry has adopted green chemistry. Chapters focus on drug design, engineering, process development, calculations to account for waste and the challenges related to use of non-hazardous reagents. This book is of interest to industrialists working in pharmaceuticals and researchers working in green chemistry.

Brief Contents

Series: Green Chemistry Series

ISSN: 1757-7039


ISBN: 9781782620501

Price: £149.00 | $245.00



Format: Hardback

Size: 234 x 156

Pages: 300

BIC: MMG, PNN, RNU

Introduction to Hazardous Reagent Substitution in Pharmaceutical Industry

Classifications of Reagents

Recyclability of reagents

Synthesis of Saxagliptin

Synthesis of Raloxifene

Synthesis of Montelukast

Synthesis of Gemcitabine

Synthesis of Clopidogrel

Synthesis of Ritonavir

Synthesis of Valsartan

Edition: 1

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Theoretical & Computational Chemistry Series

Cold ChemistryMolecular Scattering and Reactivity Near Absolute Zero

Edited by Olivier Dulieu and Andreas Osterwalder



Cold ChemistryMolecular Scattering and Reactivity Near Absolute Zero

Olivier Dulieu Université Paris-Sud, France Andreas Osterwalder Ecole Polytechnique Federale de Lausanne, Switzerland

SynopsisRecent years have seen tremendous progress in research on cold and controlled molecular collisions, Advances in techniques have opened many new possibilities to study the most fundamental aspects of molecular interactions. Through tutorials on both the theoretical and experimental aspects of research in cold and ultracold molecular collisions, this book provides advanced undergraduate students, graduate students and researchers with the foundations needed to understand this exciting field.

Brief Contents

Series: Theoretical and Computational Chemistry Series

ISSN: 2041-3181


ISBN: 9781782625971

Price: £179.00 | $300.00



Edition: 1

Size: 234 x 156

Pages: 500

Part I. Experimental Aspects of Cold Chemistry

Low Energy Scattering in Crossed Molecular Beams

Low Temperature Chemistry in Uniform Supersonic Flows

Experiments in Large Superfluid He Nanodroplets

Controlling Ultracold Chemical Reactions using Optical Lattices

Cold Ion Chemistry

Part II. Theoretical Aspects of Cold Chemistry

Cold Molecular Collisions: Quantum Scattering Calculations and their

Relevance in Astrophysical Applications

Interactions of Atoms and Molecules in Cold Chemistry

Format: Hardback

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Chemical Biology

Mass Spectrometry in Chemical BiologyEvolving Applications

Edited by Norberto Peporine Lopes and Ricardo Roberto da Silva



Mass Spectrometry in Chemical BiologyEvolving Applications

Norberto Peporine Lopes University of Sao Paulo, Brazil Ricardo Roberto da Silva University of Sao Paulo, Brazil

SynopsisMass spectrometry is one of the most widespread technologies in chemistry and has been increasingly used in biology with the rise of omics sciences. This book summarizes important mass spectrometry related methodological approaches and applications in the field of chemical biology. It provides an important compendium of theoretical and experimental techniques that can be applied to study a wide range of problems in biological systems and would therefore be of great interest to students and researchers in the fields of analytical chemistry, biochemistry and chemical biology.

Brief Contents

Series: Chemical Biology

ISSN: 2055-1975


ISBN: 9781782625278

Price: £159.00 | $260.00



Format: Hardback

Size: 234 x 156

Pages: 275

BIC: PNF, PSB, PSD

Introduction to mass spectrometry instrumentation

and methods used in chemical biology

Metabolomics

Proteomics

Mass spectrometry to discover natural products

Applications of mass spectrometry in synthetic biology

Studying enzyme mechanisms using mass spectrometry

Applications

Databases

Future perspectives

Edition: 1

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Smart Materials Series

Reactive Inkjet PrintingA Chemical Synthesis Tool

Patrick J. Smith and Aoife Morrin



Reactive Inkjet PrintingA Chemical Synthesis Tool

Patrick J Smith University of Sheffield, UK Aoife Morrin Dublin City University, Ireland

SynopsisEdited by two leading experts, the book describes the use of inkjet printing as a chemical synthesis tool in which an inkjet printer dispenses one or more reactants to form a product in situ. The book is suitable for advanced undergraduates, graduates and researchers in materials science, specifically those interested in tissue engineering, materials synthesis and additive manufacture.

Brief Contents

Series: Smart Materials Series

ISSN: 2046-0066


ISBN: 9781782627678

Price: £149.00 | $245.00



Format: Hardback

Size: 234 x 156

Pages: 250

BIC: PNN, TC, TGM

Introduction to Reactive Inkjet Printing

Droplet Behaviour

Droplet Mixing

Reactive Inkjet Printing for use in Solar Cells

Reactive Inkjet Printing in Quantum Dots

Reactive Inkjet Printing in Electronics

Reactive Inkjet Printing in Dentistry

Reactive Inkjet Printing and Silk

Reactive Inkjet Printing in Additive Manufacture

Conductive Copper and Nickel formed by Reactive Inkjet Printing

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Chemical Biology

Mechanisms of Primary Energy Transduction in BiologyEdited by Mårten Wikström



Mechanisms of Primary Energy Transduction in BiologyMarten Wikström University of Helsinki, Finland

SynopsisWritten and edited by leading experts in the field, this book describes the events of primary energy transduction in life processes. It focusses in particular on recent structural results and new biophysical insights that have been made possible by recent advances in high-resolution protein structures, in physical techniques to study reactions in real time, and in computational methods to study and refine both structures and their dynamics. Biochemists, biophysicists and chemical biologists will find this book an essential resource for a complete understanding of the molecular machines of bioenergetics.

Brief Contents

Series: Chemical Biology

ISSN: 2055-1975


ISBN: 9781782628651

Price: £169.00 | $275.00



Format: Hardback

Size: 234 x 156

Pages: 400

BIC: PHVN, PNR, PSB

Making maquette models of bioenergetic structures

Structure of respiratory complex I: “minimal” bacterial and “de luxe”

mammalian versions

Structure and function of respiratory complex I

Multi-scale Molecular Simulations on Respiratory Complex I

Coupling Hydride Transfer to Proton Pumping: the Swiveling

Mechanism of Transhydrogenase

The Na+-translocating NADH: ubiquinone oxidoreductase (Na+-NQR)

The bc1 complex: a physicochemical retrospective

and an atomistic prospective

Edition: 1

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scientific discoveries and translational research · 2017-08-23 · email: [email protected]...

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