SchoolUpdateandImpactsJune2017

STATEOFTHESCHOOLADDRESSInhisannualStateoftheSchooladdress,DeanMichaelLairmorecongratulatedtheschool’scommunityforachievingthetopspotamongveterinaryschoolsintheworldbyQSWorldUniversityRankingsforthethirdyearrunning.Hecreditsthatrecognitiontotheschool’sabilitytoattractthebestandbrighteststudents,andfacultyandstaffdedicatedtocompassionatecare,clinicalinnovation,andhigh-impacttransdisciplinaryresearch.Otherhighlightsofthispastacademicyearinclude:• IncreasedfacultyinvolvementintheBiomedicalandEngineering

EntrepreneurshipAcademywith19inventiondisclosuresand16patentsfiled(fourhavebeengrantedsofar).

• Five-yeargrantrenewalfromtheNIHfortheUCDavisCounterACTCenterofExcellencetoidentifyimprovedmedicalcountermeasuresforchemicalthreatagentsinhumansandanimals.

• DevelopmentofthefirstPETequineprogramintheworld-usedforresearchonequinebonestressmodeling,osteoarthritis,laminitisandtendondisease.

• LaunchoftheVeterinaryInstituteofRegenerativeCures.• EstablishmentoftheBioanalyticalResearchCore,specializinginpharmacokinetic-pharmacodynamicstudies

atpreclinicalandclinicalstagesofdevelopment.• Outstandingcustomerservicefromthehospitalstaffforapproximately55,000veterinarypatientsthisyear.• IncreasedavailabilityofclinicaltrialsthroughtheVeterinaryCenterforClinicalTrials(77currentlyactive).• Highboardcertificationratesamongthehospital’sresidents.• Broaderdiversityoftheschool’scommunitybeginningwithoutreachandintensivetrainingprogramsforK-

12andcommunitycollegestudents.• Advancingthewell-beingofanimalsandpeoplewiththeKnightsLandingOneHealthClinicanddisaster

responsetraining.• Continuedsupportfromphilanthropicpartnersthathelpkeepstudentdebtincheckandsupportcutting-

edgeresearch.HealsodiscussedafewmajorchallengesinparticularthefutureVeterinaryMedicalCenter—a10-yearmasterplanforclinicalfacilitiesthatwilltakeplaceinphases.Thecompletepresentationcanbeviewedonlineat:www.vetmed.ucdavis.edu/about_vetmed/school_updates.cfm2017COMMENCEMENTCongratulationstoallofthenewgraduatesoftheUCDavisSchoolofVeterinaryMedicine.Amongthosereceivingdegreesatthe66thCommencementCeremonyheldattheMondaviCenterwere134DVMstudents,39residentsand11studentsintheMasterofPreventiveVeterinaryMedicineprogram.Dr.GraceBransford,a1998graduateoftheschoolandownerofRossValleyVeterinaryHospitalinSanAnselmo,wastheinvited

CommencementSpeaker.RachelFerriswasawardedtheschoolmedal,thehighesthonorforagraduatingstudentinrecognitionofoutstandingacademicandclinicalperformance.FerriswillinterninsmallanimalmedicineattheAnimalMedicalCenterinNewYork.

“Holytoe-tappingchickens,we’vemadeit!”saidLoriHammond,studentspeaker(picturedontheleft).

Forsomeonewhohasaspiredtobeaveterinariansincekindergarten,thejourneytothestageatcommencementhasbeenastrugglethatnotallwouldhavethefortitudetocomplete.AfterabackpackingtripfollowingherundergraduatesophomoreyearatUCDavis,Hammonddevelopedararespinalarterialvenousmalformationthatcompressedherspinalcord80-90percentandleftherparalyzedattheT-5T-7level.Sheperseveredthroughintensephysicaltherapytolearntowalkagainwiththeaidofawalker.

Then,afterenteringveterinaryschool,Hammondwasdiagnosedwithleukemia.Afterchemotherapy,HammondreturnedtojointheClassof2017.Thescariestdayofvetschoolwashersecondfirstday,butsherecalledbeingimmediatelyembracedbyhernewclassmates.BythetimeHammondfinishedspeaking,thereweren’tmanydryeyesorpeoplesittingintheirseats.

NEWLEADER

HyemiSeveningwasselectedasthenewAssistantDeanforAdvancement.Seveninghasawealthoffundraisingandmanagementexperience,andwasmostrecentlyemployedasourinterimAssistantDeanforAdvancementsinceDecember2016.ShejoinedtheschoolinAugust2015asaSeniorDirectorofDevelopmentandhassuccessfullyraisingmajorgiftstosupportanumberofprogramsandinitiatives.PriortojoiningtheschoolsheservedasaSeniorDirectorforDevelopmentattheUCDavisBettyIreneMooreSchoolofNursingandatIowaStateUniversity,andasDirectorofDevelopmentattheUniversityofLouisville.AstheAssistantDean,Seveningwillberesponsiblefordesigning,developing,deliveringandadministeringtheschool’scomplexfundraisingprogram;identifyingnewdonorprospects

throughresearch;developingmaterials,marketingplansandorganizingrelatedprograms/events;cultivating,stewardingandsolicitingdonors;andmanagingtheschool’sfundraisingprogramwithinthecontextofoverallfundraisingeffortsatUCDavisFACULTYRECRUITMENTS• ProfessorofNeurology/Neurosurgery• ProfessorofAnesthesiology• ProfessorofDermatology• Professor(50%)/ProfessorIn-ResidenceofInfectiousDisease(50%)• Professor(50%)/ProfessorIn-Residence(50%)ofRespiratoryBiologyorToxicology• ProfessorofClinicalNeurology/Neurosurgery• ProfessorofClinicalSmallAnimalEmergencyandCriticalCare• ProfessorofClinicalMicrobiology-SanBernardino• ProfessorofClinicalAvianDiagnostics-Turlock• ProfessorofClinicalPathology-Tulare• LargeAnimalClinicDirector

• SpecialistinCooperativeExtension-BeefCattleHerdHealthandProduction• SpecialistinCooperativeExtension-DairyCattleProductionHealth• SpecialistinCooperativeExtensioninAntimicrobialStewardship• HealthSciencesAssistantClinicalProfessorinCommunityPractice-TheriogenologyVETERINARYMEDICALCENTER–LEADINGTHEWAYThefutureVeterinaryMedicalCenterbringstogethertheschool’scommunityofscholars,cliniciansandveterinarystudentsinfacilitiesdesignedtoprovideefficientpatientcarewithimmediateaccesstostate-of-the-arttechnologies.Thefacilitydesignwillencouragetheapplicationofscientificdiscoveriesfrommultipledisciplinestotheclinicalsettingtoenhancepatientcareandtheeducationalenvironmentforveterinarystudentsandresidents.TheLivestockandFieldServiceCenteristhefirstpatientserviceareatocomeonline.ThecenterhasbeendesignedinconsultationwithTempleGrandin,PhD,wellknownforhergroundbreakingworkinengineeringhumaneanimalfacilitiesandisafellowintheSocietyofBiologicalandAgriculturalEngineers.Grandinpartneredwithustorefinepreliminaryplansanddesignthebestpossibleenvironmentforlivestockpatienthandling,careandclinicalteachingemphasizingmodernconceptsinanimalwelfare.

Basictechnicalskillsandknowledgeoflivestockandtherolesoflivestockinoursocietyareanimportantpartofthestudenteducationalexperience.Byprovidingasafeandcontrolledenvironmentandadiversecaseload,rotationsthroughtheLivestockMedicineServiceallowstudentstoparticipateinsurgeriessuchascastrations,commonabdominalsurgeries,C-sectionsandlegfracturerepairs.Thisrotationalsooffersstudentsadditionalexperiencewithradiology,ultrasound,endoscopy,andevenlaparoscopy,CTandMRI. CONNECTINGANIMALHEALTHCAREANDPHARMACYEDUCATIONRecognizingthepetownertrendtoobtainprescriptionsfortheirpetsfromcommunity-basedpharmacies,onlineretailersorcompoundingfacilities,theAmericanVeterinaryMedicalAssociationrecentlyannounceditsplanstoworkwiththeNationalAssociationofBoardsofPharmacytoofferveterinaryeducationforpharmacists.Currently,schoolsofpharmacyintheU.S.arenotrequiredtoincludeveterinarypharmacologyintheircurriculum.Alreadyattheforefront,theschoolhasestablishedtrainingforDoctorofPharmacy(PharmD)graduatesthrougharesidencyattheveterinaryhospitalandtheClinicalPharmacyFellowshipProgramattheUCVeterinaryMedicalCenter,SanDiego.UCDavisisoneofonlyfourrecognizedprogramsacrossthecountrythatoffersadvancedtrainingforpharmacists,specificallydesignedtointegratetheminveterinarymedicineandprepareprofessionalswhoarewell-suitedtomeetthegrowingindustryneedsinveterinarymedicine.

ResidentsandfellowsdividetheirtimebetweenDavisandSanDiego.Throughadvancedclinicaltraininginallaspectsofsmallanimalclinicalpharmacologyandrigorousresearch,postgraduatepharmacistsareabletounderstandandparticipateinthemanagementofsmallanimalpatientswithavarietyofcommondiseases,performbasiccompoundingproceduresandoverseetechnicalstaffperformingcompoundingfunctions.Thepharmacyresidencyandfellowshipprogramsrelyexclusivelyonpartnershipsforfundingtosupporttheoperationalneedsoftheprogram,whichincludesresearchandinnovativeclinicaltrainingsupport.

UCDAVISEXPANDSCARDIOLOGYSERVICESINSANDIEGOWithagrowingnumberofpatientsinneedofexpertcardiologyservicesintheSanDiegocommunity,theUCVeterinaryMedicalCenter–SanDiego(UCVMC-SD)hasopenedasecondlocationinSanMarcos.Board-certifiedcardiologistsTimHodgeandJoaoOrvalhoofferawidearrayofmedicalandinterventionalcardiologyprocedures.TheteamisalwaysavailableforconsultationswiththereferralveterinarycommunitythroughoutCalifornia,andencouragegeneralpractitionerstocontactthemwithquestionssurroundingtheirpatients’cardiachealth.MedicalcardiologyproceduresofferedbyUCVMC-SDinclude:cardiovascularconsultations,echocardiography(2-D,colorDoppler,spectralDoppler,tissueDoppler,transesophagealandlive3-D),electrocardiography(digital12leadelectrocardiograms,Holtermonitors,andeventmonitors),digitalradiographyandfluoroscopy,andbloodpressuremeasurement(indirectanddirectmethods).Interventionalcardiologyproceduresinclude:angiography(selectiveandnon-selective),pacemakerimplantation(singleanddual-chamberpacing),patentductusarteriosus(PDA)occlusion(PDAcoilembolization,vascularplugsandamplatzcanineductaloccluders),andballoonvalvuloplasty(pulmonic,tricuspidandmitralvalvestenosis,aswellasballooningofothercongenitalcardiacdefects).InarecentcaseElsa,a2-year-oldLabradorretriever,wasdiagnosedwithPDA.Thiscongenitaldefectisacommunicationbetweentheaortaandpulmonaryarterythatissupposedtocloseapproximately24hoursafterbirth.Manydogswiththisdefectwillgointocongestiveheartfailurebythetimetheyare1yearofage.ElsawasdiagnosedandaminimallyinvasiveproceduretooccludethePDAwasperformedbyDrs.HodgeandOrvalho.Elsawasdischargedfromthehospitalthenextdaywithnocongestiveheartfailuremedications,andcontinuestodofine.SOUTHERNCALIFORNIAMOUNTAINLIONS’GENETICCONNECTIVITYDANGEROUSLYLOWIfadangerouslyinbredpumapopulationinSouthernCaliforniaistosurviveinthefuture,anurgentneedforgeneticconnectivitymustbemet,accordingtotwoscientificpapersfromateamofresearcherscoordinatedbyUCDavis,andinvolvingscientistsattheUniversityofWyomingandtheUniversityofMassachusetts–Amherst.Thefirstpaper,publishedinthejournalRoyalSocietyOpenScienceinMay,reportsthatthepumapopulationof

about20adultsintheSantaAnaMountainshasthelowestgeneticdiversityeverreportedforpumasbesidestheFloridapanther,whichnearlywentextinctfromgeneticcauses.Thepumas’isolationisprimarilyduetosurroundingurbanizationfromLosAngelesandSanDiego.PumamovementsinandoutoftheSantaAnaMountainsrequirethemtocrossI-15—an8-10laneinterstatehighway.UniversityofWyomingresearchersconductedgeneticanalysesofbothradiocollaredanduncollaredpumastodevelopamultigenerationpedigree.Thisshowedwherepumasandtheiroffspringwereborn,andwhethertheysuccessfullymigratedandreproducedaftercrossingI-15.AlthoughsevenmalescrossedI-15overthepast20years,onlyone—malepuma#86(M86)—wasabletosuccessfullyproduceoffspringintheSantaAnasaftermigratingfromthegeneticallydiversepopulationtotheeast.Byproducingatotalof11detectedoffspring,M86rapidlydisseminateduniquegenesintotheinbredpopulation,whichreducedthelevelofinbreedingandsignificantlyincreasedgeneticdiversity.Unfortunately,M86washitbyacarbetween2014and2015,andmorethanhalfofhisoffspringareeithernowdeceasedorincaptivity.“Thisisconsistentwithmortalityrateswefoundpreviouslyintheregion,”saidWinstonVickers,awildlifeveterinarianfromUCDavis’KarenC.DrayerWildlifeHealthCenterwhoconductedmostofthefieldresearch.“Onlyoneothermigrant,namedM119,remainsintheSantaAnaMountains,butwhetherheisaliveorproducedoffspringisuncertain.”

Thatsinglemalemountainlion,M86,performedwhatamountstoa“geneticrescue,”saidseniorauthorHollyErnest,awildlifepopulationgeneticistandresearchveterinarianattheUniversityofWyoming.“Ourstudyalsoshowshowquicklyhisgeneticswerelostbyhighmortalitylevelsofhisoffspring.ThispopulationneedshelptoregainhealthygeneticdiversityandpersistintheSouthernCalifornialandscape.”Thesecondpaper,publishedinthejournalPLOSONE,providesapotentialsolutiontothisissue.Init,theresearchersproposeaconservationnetworkforpumasspanningtheSantaAnaMountainsandtheEasternPeninsularMountains.Usinggeneticdata

anddatafromGPSradio-collaredpumas,thisanalysisidentifiedcriticalhabitatpatches,movementcorridors,andkeyroadcrossinglocationsacrossI-15thatwouldallowpumastopersistandincreasegeneticdiversity.“WithoutcontinuedemigrationintotheSantaAnaMountainsbypumascomingfromtheeastofI-15,erodinggeneticdiversityandcontinuedinbreedingareexpectedtoresume,”saidveterinarianWalterBoyce,co-directoroftheWildlifeHealthCenter’sSouthernCaliforniaMountainLionStudywithVickers.PrimaryfinancialsupportfortheresearchwasprovidedbytheSanDiegoCountyAssociationofGovernments,andtheCaliforniaDepartmentofFishandWildlife.

RXONEHEALTHCOURSEThegoaloftheRxOneHealth2017courseistoprovidea“prescription”orRxforearlycareerhealthprofessionalstopreparethemforimmediateengagementinglobalhealthcareersthatwilldemandeffectiveproblemsolvingskills,cross-disciplinaryengagements,andsolidfoundationsinfieldandlaboratoryactivities.Thisintensivecourseisaimedatalevelappropriateforrecentgraduatesorstudentsinmedicalandveterinaryschoolsaroundtheworld,aswellasotherearlycareerhealth,agriculture,andconservationprofessionals.ThecourseisbasedontheprinciplesandpracticesofOneHealth.Participantswillbeimmersedinsettingsthatwillillustratethatthehealthofpeople,animalsandtheenvironmentareinextricablylinked.RxOneHealth2017willprovideparticipantswithdirectaccesstomentors,tools,andknowledgetoallowthemtoapplyaOneHealthapproachtotheirlives’work.Courseactivitieswillallcenteronexposingparticipantstoreal-worldOneHealthsituations,challengingthemtoconsiderthemanyinter-relatedissuesthataretypicalofcomplexproblems,andtoseefirsthand,andevendevelopthemselves,OneHealthstrategiesforovercomingthesechallenges.AllparticipantswillimprovetheirunderstandingandgraspofOneHealthcompetenciesintheareasof:cross-disciplinarycommunications;professionalintegrity,ethicsanddiplomacy;visionintegrationandadvocacyforchange;teamwork;andsystemsthinking.Inaddition,exposuretoconceptsandskillsnecessaryfordesigningandparticipatinginemerginginfectiousdiseaseandtoxincontrolprogramswillbeprovided.LedbytheUCDavisOneHealthInstitute,UniversityofRwanda,andSokoineUniversityofAgriculture,RxOneHealthisbeingtaughtforthefirsttimeinJune2017toamaximumof22students.ItscurriculumhasbeenbuiltonthetremendouslegacyofacoursecalledEnvirovetSummerInstitutethatwasco-ledbyUCDavisandofferedmultipletimesthroughoutthe1990sand2000s,andwhichtrainedmorethan400veterinariansandveterinarystudentsfromaroundtheworldinecosystemhealth(aprecursortoOneHealth).RxOneHealthwillbeanimmersion-style,hands-on,intensivetrainingcoursedeliveredovera4-weekperiod,withallcourseworkoccurringinTanzaniaandRwandain2017.InTanzania,studentsgainedfirst-handknowledgeandexperiencewithavarietyofOneHealthchallengesandsolutions,includingtopicssuchas:animal-basedfoodsystemsandzoonoticdiseasechallenges(e.g.bovinetuberculosis);emerginginfectiousdiseaseidentificationandcontrol;wildlifecapture;biosafetyandsecurity;culturalandecologicaltourism;wildlifeconservationandparkmanagement;waterqualityanddeliverysystems;healthandfoodchallengesfacingunderservedcommunities;andenvironmentalcontaminants.AftertwoweeksinTanzaniastudentstraveledtoRwanda,wheretheywillengageinanimmersiveexercisetoenvisionaOneHealthCooperativeforacommunityoutsideVolcanoesNationalParkthatwouldaddress,balance,andsolveveryrealchallengesfacingthecommunitywithregardtosafeandefficientlivestockproductionandwelfare(dairycows);nutrition(milkquality,production,anddelivery),communityhealth(maternal/childhealthcareinterventions)andwildlifeconservation(mitigatingwildlife-humancontactoutsidethepark)amidstchangingclimateandsocioeconomicenvironments.Togetherwithmentorsandstakeholders,thestudentswilllaythegroundworkforaOneHealthCooperativecalledKinigiFarms,andwillcreateaplanandmaterialsthatcanbeusedbypartnersinRwandatogarnersupportforthisandsimilarinitiativesthatstrivetobalanceconservation,health,andlivelihoods.

ORTHOPEDICSURGEONSSUCCESSFULLYUTILIZEBONEREGROWTHTECHNOLOGY

Fiveyearsago,UCDavisveterinaryoralsurgeonsstartedusingabonegrowthstimulatortoregrowjawbonesindogs.Todate,theyhavesuccessfullyregrownnearlythreedozenjawbones.Now,thattechnologyisbeingutilizedinorthopedicsurgerytorepairboneinjuriesindogs’legs.

Dr.AmyKapatkin,chiefoftheOrthopedicSurgeryService,hasimplementedtheregrowthstrategyin11dogs,withninereturningtofullfunctionandtwowithacceptablefunction.All11casesinvolveddogswithnonunionfracturesintheirlimbs,meaningpreviousattemptstorepairtheirbreaksfailedtounitetheboneasoneagain.Alldogsinthestudyhadatleastoneprevioussurgery,whilesomehadasmanyasfivepreviousattemptstohealtheirboneproperly.

Whilenotallregrowthsurgeriesarethesame,thebasicpremiseoftheprocedureistoplaceascaffold(calledacompressionresistantmatrix[CRM])saturatedwithabonemorphogeneticprotein(BMP)intothebonedefectinhopesofstimulatingadditionalbonegrowthfromthesurrounding,healthynativebone.TheuseofCRMandBMPspecificallytargetedareasofpersistentbonedefectafteratleastonefailedsurgery.Previously,theonlyadditionaltreatmentwouldbetotrytosetthebreakagaininthesamefashionwiththedog’sowngraft,whichinmanycases,carriesthesamepotentialfailrateduetoalackofbloodsupplytothebone.“Weareexcitedaboutthisnewtreatment,andareoptimisticthatouruseinorthopedicscanhavethesamelong-termpositiveresultsouroralsurgeonshaveseenwithjawbones,”saidDr.Kapatkin.“Thisinitialsuccessholdsgreatpromiseforfuturepatients–notjustatUCDavis,butthroughouttheveterinarycommunity.”ThesecasesatUCDavisrepresentthefirstlargecaseseriesuseofBMPtotreatlongbonenonunionsinveterinarymedicine,anexampleofhowthefacultyareleadingthewayinnewtreatmentdiscoveriesandadvancingveterinarymedicinetonewheights.

GENETICRISKFACTORFOREQUINEEYECANCERIDENTIFIED

InthecoverarticlefortheInternationalJournalofCancer,scientistsannouncedthediscoveryofageneticmutationinhorsesthatishypothesizedtoimpacttheabilityofdamagespecificDNAbindingprotein2tocarryoutitsstandardrole.Normally,theproteinconductsDNAsurveillance,lookingforUVdamageandthencallinginotherproteinstohelprepairtheharm.

“Themutationispredictedtoaltertheshapeoftheproteinsoitcan’trecognizeUV-damagedDNA,”saidDr.RebeccaBellone,anequinegeneticistattheVeterinaryGeneticsLaboratoryandassociateadjunctprofessorattheschool.“Webelievethisisariskfactorbecausecellscan’trepairthedamageandaccumulatemutationsintheDNAthatleadtocancer.”

Severalequinebreeds,includingHaflingers,haveahigheroccurrenceoflimbalSCC,theformofthediseasethatoriginatesinthejunctionbetweenthecornea—theclearsurfaceoftheeyeball—andtheconjunctivathatcoversthewhiteoftheeye.Aformerstudy,conductedbyBelloneandoneofherresearchpartners,Dr.MaryLassaline,foundthatabout26percentofSCC-affectedhorsesinaretrospectivestudywereHaflingers.

“Thefactthatweseethistypeofcancerinarelativelysmallbreedwithanarrowpedigreemakesitagoodmodeltostudy,”saidLassaline,associateprofessorofclinicalequineophthalmology.

OcularSCCcanleadtovisionlossandevenlossoftheeye.Inadvancedcases,SCCcanbelocallyinvasiveandspreadtotheorbitandeatawayatboneandeventuallythebrain—leadingtolossoflife.TheserecentstudyresultsofferahugeapplicationinidentifyinghorsesatriskfordevelopingSCContwofronts.

“First,it’simportantfortheindividualhorsewithaknownriskandwecanbemorevigilantaboutexamsaswellasprotectingtheireyesfromUVexposure,”Lassalinesaid.“Ifdetectedearly,wecanremovethetumorandsavetheeye.Secondly,thatknowledgeisimportantformakinginformedbreedingdecisions.”

ScientistsattheUCDavisVeterinaryGeneticsLaboratorywereabletodevelopagenetictestforhorsesbasedontheresearch.Thetestdeterminesifahorsecarriesthemutationorhastwocopiesoftheriskvariant,puttingitathighestriskforcancer.

Inadditiontoimprovingthehealthofhorses,thisstudymayhaveimplicationsforhumanhealthaswell.ThegenefoundtobeassociatedwithequineSCCisalsolinkedinhumanstoxerodermapigmentosumcomplementationgroupE—adiseasecharacterizedbysunsensitivityandincreasedriskofcutaneousSCCandmelanoma.“Thereisaninterestingparallelinhumanswithmutationinthisprotein,”Bellonesaid.“Nowwehavetheabilitytounderstandwhyit’saffectingtheeyesofhorsesaswellastheskinofhumans.”

ThisresearchwassupportedinpartbygenerousdonorstotheCenterforEquineHealthaswellastheMorrisAnimalFoundation.

SAFERSEDATIONFORCATSONTHEHORIZONAdvancingpatientcareisoneoftheprimarygoalsoftheCenterforCompanionAnimalHealth(CCAH).Oftenthebestwaytoachievethatgoalistofundresearchprojectsthatlayafoundationforlargerclinicaltrialsthateventuallymaketheirwayintopractice.ThankstoCCAHdonorswhosupporttheseendeavors,veterinaryanesthesiologistBrunoPypendoprecentlypublishedastudyinVeterinaryAnesthesiaandAnalgesiathatmayleadtosafersedationtechniquesforcats.Hisresearchexaminedthecardiovasculareffectsofdexmedetomidine,withorwithoutMK-467,whengivenintravenouslytocats.Dexmedetomidineiswidelyusedtosedateanimalsorprovidepainrelief.However,thedrugdoescomewithadversecardiovasculareffectssuchasvasoconstrictionanddecreasedheartrate.“OurstudyshowedthatbyaddingMK-467whenadministeringdexmedetomidine,wecanbluntsomeofitscardiovascularsideeffectswithoutaffectingitsanesthetic/analgesicproperties,”Pypendopsaid.Hepointedoutthatyoung,healthycatsarebetterabletotoleratetheeffectsofdexmedetomidine,whileolder,sickercatsaremorelikelytosufferadverseeffects,soitsuseisoftenavoided.SeveralstudiesfromFinlandshowMK-467tobeeffectiveatmediatingsomeofthenegativecardiovasculareffectsindogsandPypendopwasaskedbycolleaguestheretopursuethisinitialstudyoncats.WiththehelpoftwoprimaryCCAHgrants,PypendopandhisteamwasabletolaunchaninvestigationintotheefficacyofusingMK-467incats.HeapproachedtheWinnFelineFoundationforfurtherfundingwiththesupportofamatchingcommitmentfromtheCCAH.WhileMK-467isstillbeingexploredthroughresearchandnotcommerciallyavailable,Pypendopsaidthedrugshowspromiseasameansofimprovingsedationandanesthesiaforcats,especiallyforolderfelinesorthosewithsystemicdisease.THECHANGINGFACEOFVETERINARYMEDICINE

Weliveinarichmulti-culturalsocietywhereveterinariansandpetownershavedifferentworldviews,languages,religiousbeliefs,biases,genderidentity,abilitiesandotherdiversecharacteristics.Asaveterinarycommunity,it’simportantthatweacceptthesedifferences,learnfromeachotherandappreciatetheunifyingelementweallshare–thedesiretohelpanimals.Forty-threepercentoftheincomingveterinarystudents(Classof2021)atUCDavisarenon-Caucasian,whichreflectsthechangingdemographicsofCaliforniaandthenation.

Howmightculturaldiversityimpactveterinarycommunications?Alanguagebarrierbetweenveterinarianandclientcouldimpacttheclient’sunderstandingoftheprescriptiondoseinstructions.Duetoculturalnorms,thatclientmaybereticenttoaskforclarification.Thatdifferencecouldresultinanoverdose.Eyecontactisanotherexample.Insomecultures,makingeyecontactisconsidereddisrespectful,butwesternersseedirecteyecontactasasignofattentionandtrust.Students,facultyandstaffattheschoolhavetheopportunitytoparticipateineducationalactivities,workshopsandseminarstolearnaboutandembracetherangeofculturaldifferencesthatmakeupsociety,andhelpustodeliverbetterveterinarycare.Oneinitiativefundedannuallybytheschoolprovidesfortenstudents,facultyandstafftoparticipateintheonlinecertificatetrainingprogramofferedbytheCenterforExcellenceforDiversityandInclusioninVeterinaryMedicine,jointlysponsoredbyPurdueUniversityCollegeofVeterinaryMedicineandtheAssociationofAmericanVeterinaryMedicalColleges.Theprogramisdesignedtoimprovetheircommunication,leadership,teaching,learning,andculturalcompetencyskills.“IfoundtheprogramworthwhileasthereissomuchresearchintoinclusionanddiversitythatIdidnotknowandsomeoftherecommendationsforhowtoapproachadiverseclientpopulationwerenewtome.” ~KatherineHansen,AssistantProfessorProgramparticipantscompleteaseriesof13learningmodules,threehoursofcommunityengagement,fourone-hourpertinentactivities(i.e.lectures,festivals,artexhibits),andafinalcapstonepaper.Certificatesandninehoursofcontinuingeducationcreditareawardeduponcompletion.HOSPITALACQUIRESNEWCARDIACSURGERYEQUIPMENT

Thankstoananonymousfoundationthatenjoyssupportingfeline-focusedneeds,adonationwasrecentlymadetothehospitaltopurchaseastate-of-the-artfluoroscopyunitfortheCardiologyService.TheOEC9900EliteMobileC-arm(withanadvancedcardiacpackage)willsoonreplaceasimilarunitthehospitalhasbeenusingfor

morethan15years.Theequipmentsupportsinterventionalcardiologyproceduresbyprovidinglivemotionradiologyobservedbythecardiologiststohelpguidethemintraoperativelyduringsurgeries.Theuseof“livex-rays”isalsobeingutilizedbyUCDavis’SoftTissueSurgeryServicetoguidesurgeonsminimallyinvasivelythroughthebody.Thiscutting-edgetechnologyhasmadesurgeriesquickerandsafer,andinsomecases,offeredviablesurgicalinterventionwheretherewerepreviouslynotreatmentoptions.

Thisnewfluoroscopyunitprovidesbetterqualityimagingwithhigherresolutionandadaptabilityforcardiovascularimagingthanthepreviousversion.Theseimagesarenowmorereadilyimportedintohospitalserversforeasierconsultationwithotherspecialistswhomaybeinanotherpartofthehospital.Finally,theunitprovidesimprovedradiationsafetyfortheveterinarians,technicians,andstudentsintheoperatingroom.Someoftheproceduresmostcommonlyperformedtofixcongenitalheartdefectsusingthisequipmentinclude:placementofpacemakers,balloonvalvuloplastyforpulmonicstenosis,andclosureofpatentductusarteriosus–avesselthatallowsbloodtoskipcirculationtothelungs.Recently,theserviceusedthefluoroscopyunittoplaceapacemakerinadonkeyandperformanangiogramstudyonaparrot.

LICENSUREFORUNIVERSITYVETERINARIANSINCALIFORNIABeginninginJanuary2017,licensureisnowrequiredforveterinarianswhoparticipateinpatientcarewithinuniversitiesinCalifornia.Previouslyveterinarianswereexemptfromlicensureastherearearelativelysmallnumberofveterinarianswiththelevelofadvancedtrainingneededtomaintainthequalityofourclinicalprogramsworldwide,thereforeitisessentialtobeabletorecruitinternationallyforthisexpertise.IfthoseveterinarianswererequiredtoobtainindividuallicensurebystateboardexaminationandpossiblyalsotheECFVG,thiswouldcrippletheschool’sabilitytorecruitandretainthoseindividualsandhavefar-reachingimpactsonthequalityofourprograms.Inordertomeetthisrequirement,administratorsfromUCDavisandWesternUniversityofHealthSciencesworkedwiththeCaliforniaVeterinaryMedicalBoard(CVMB)todevelopaUniversityVeterinaryLicense.VeterinariansareissuedaUniversityVeterinaryLicenseaftertheyattendthe26-hourCaliforniaLicensingCurriculum,receiveabackgroundcheck,andpasstheCVMBVeterinaryLicensingExamination.Inearly2017,theVeterinaryMedicalTeachingHospitalestablishedataskforcetodevelopaCaliforniaLicensingCurriculumthatcouldbedeliveredon-sitetofacultyandhouseofficers,whichwaschairedbyJaneSykes,ChiefVeterinaryMedicalOfficer,andincludedDrs.LaneJohnson,JoanDeanRowe,JoieWatsonandBretMcNabb.ThecurriculumwasapprovedbytheCVMBonMay25,2017.FromJune1-3,2017,44facultymembersandhouseofficerstooktheCaliforniaLicensingCurriculum,whichwasdeliveredby12prominentveterinariansfrombothwithinandoutsidetheschool.ThecurriculumwillbeofferedagainfromAugust3-5,2017,andonanannualbasiselectronicallytoincominghouseofficersandfaculty.Currentlyanother43veterinariansarescheduledtotakethecurriculuminAugust.UniversityveterinarianscanalsotakethecurriculumofferedinnorthernandsouthernCaliforniainMarchandNovemberiftheyareunabletoattendthecurriculumofferedbytheuniversity.LicenseswillbeissuedoncetheCVMBhascompletedupdatestotheirBreEzeonlinesubmissionsitetoallowprocessingforUniversityVeterinaryLicenses.Thisisanticipatedtooccurinlate2017.AWARDSANDHONORSTheschool’s2017AlumniAchievementAwardswerepresentedduringtheCommencementCeremonies.Thisyear’srecipientswere:

• DallasHyde-Inrecognitionofhisoutstandingleadershipandaccomplishmentsinadministration,research,postgraduateeducationandprofessionalserviceintheschool.

• JonnaMazet-Inrecognitionofhersuperiorresearchandteachingtowardimprovingglobalhealthforpeopleandanimals,andconservationofthreatenedspecies.(pictured)

• BillRood-Inrecognitionofhisleadershipandcommunityimpactastheco-founderofRoodandRiddleEquineHospital.

• TedStashak-Inrecognitionofhissustainedcommitmentandeffortstoadvancetheeducationandknowledgeofveterinarians,farriers,andhorseownerstoimprovethehealthandwellbeingofhorses.

• JohnStuelpnagel-Inrecognitionofextraordinarycontributionstosocietythroughhispioneeringwork,entrepreneurialspiritandvisionfortheapplicationofgeneticsequencing.

Eachyearmembersofthefacultyreceiveawardsinrecognitionoftheirservice,research,andteachingcontributions.Thisyearthefollowingfacultywerehonored:

• PatriciaConrad,2017AVMALifetimeExcellenceinResearchAward• LarryCowgill,2016Hill’sAmericanCollegeofVeterinaryEmergencyandCriticCareJackMaraScientific

AchievementAward• TravisHenry,RobertWiggs2016AmericanVeterinaryDentalCollegeOutstandingCandidateAward• KateHurley,2017MaddieHeroAward,MaddiesFund• MargueriteKnipe,UCDavisAcademicFederation’s2017AwardforExcellenceinTeaching• ChristineKreuderJohnson,UCDavisAcademicSenate’s2017DistinguishedPublicServiceAward• JonnaMazet,2016ZoetisAwardforResearchExcellence• JonnaMazet,2017RemarkableWomenofUC• JonnaMazet,2017TomHall/NelsonSewankamboMid-Career

AwardfromtheConsortiumofUniversitiesforGlobalHealth(CUGH)

• JorgeNieto,2016SVMFacultyClinicalExcellenceAward• JoannePaul-Murphy,AwardforOutstandingServicesto

KakapoConservation(pictured)• SueStover,2016UniversityofKentuckyEquineResearchHall

ofFame• SueStover,2016AVMALifetimeExcellenceinResearchAward• BillVernau,UCDavisAcademicSenate’s2017Distinguished

TeachingAward• BillVernau,SchoolofVeterinaryMedicine2016Distinguished

FacultyTeachingAwardUpcomingContinuingEducationOfferingsJuly22-2310thAnnualBacktoSchoolSeminar,UCDavisOctober13-15FallFestival,UCDavisForafulllistingofCEprogramspleasevisitthewebsiteat:http://www.vetmed.ucdavis.edu/CE/RECENTFACULTYPUBLICLATONSAmissensemutationindamage-specificDNAbindingprotein2isageneticriskfactorforlimbalsquamouscellcarcinomainhorsesBelloneRRLiuJ,PetersenJL,MackM,Singer-BerkM,DrögemüllerC,MalvickJ,WallnerB,BremG,PenedoMC,LassalineM.IntJCancer.2017Apr20.doi:10.1002/ijc.30744.[Epubaheadofprint]http://onlinelibrary.wiley.com/doi/10.1002/ijc.30744/fullOutcomeofnonunionfracturesindogstreatedwithfixation,compressionresistantmatrix,andrecombinanthumanbonemorphogeneticprotein-2MassieAM,KapatkinAS1,FullerMC,VerstraeteFJ,ArziB.VetCompOrthopTraumatol.2017Mar20;30(2):153-159.doi:10.3415/VCOT-16-05-0082.Epub2017Jan17.https://vcot.schattauer.de/en/contents/archivestandard/issue/2465/manuscript/27052.htmlHumanandfelineadipose-derivedmesenchymalstemcellshavecomparablephenotype,immunomodulatoryfunctions,andtranscriptomeClarkKC,FierroFA,KoEM,WalkerNJ,ArziB,TepperCG,DahlenburgH,CicchettoA,KolA,MarshL,MurphyWJ,FazelN,BorjessonDLStemCellResTher.2017Mar20;8(1):69.doi:10.1186/s13287-017-0528-z.https://stemcellres.biomedcentral.com/articles/10.1186/s13287-017-0528-z

Dr.PamelaLein,DirectorCounterACTCenterofExcellence,examinesbrainsampleswithpost-doctoralresearcherSuangsudaSupasai.

Polychlorinatedbiphenylandpolybrominateddiphenyletherprofilesinserumfromcattle,sheep,andgoatsacrossCaliforniaSethiS,ChenX,KassPH,PuschnerB.Chemosphere.2017Aug;181:63-73.doi:10.1016/j.chemosphere.2017.04.059.Epub2017Apr14.http://www.sciencedirect.com/science/article/pii/S0045653517305957Detectionof3,3'-DichlorobiphenylinHumanMaternalPlasmaandItsEffectsonAxonalandDendriticGrowthinPrimaryRatNeuronsSethiS,KeilKP,ChenH,HayakawaK,LiX,LinYLehmlerHJ,PuschnerB,LeinPJ.ToxicolSci.2017May16.doi:10.1093/toxsci/kfx100.[Epubaheadofprint]https://academic.oup.com/toxsci/article-lookup/doi/10.1093/toxsci/kfx100Evolutionofavianencephalomyelitisvirusduringembryo-adaptationHauckR,Sentíes-CuéCG,WangY,KernC,ShivaprasadHL,ZhouH,GallardoRAPMID:28532787DOI:10.1016/j.vetmic.2017.04.005VetMicrobiol.2017May;204:1-7.doi:10.1016/j.vetmic.2017.04.005.Epub2017Apr9.AmylasesandTheirImportanceduringGlycanDegradation:GenomeSequenceReleaseofSalmonellaAmylaseKnockoutStrainsArabyanN,HuangBC,WeimerBCPMID:28522713DOI:10.1128/genomeA.00355-17GenomeAnnounc.2017May18;5(20).pii:e00355-17.doi:10.1128/genomeA.00355-17.OutcomeaftermedicalandsurgicalinterventioninhorseswithtemporohyoidosteoarthropathyEspinosaPM,NietoJE,EstellKE,KassPH,AlemanMPMID:28517110DOI:10.1111/evj.12701EquineVetJ.2017May18.doi:10.1111/evj.12701.[Epubaheadofprint]