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M.Tech.: Nanotechnology

(2014 - 15)

Scheme of Teaching and Examination &

Syllabus

Department of Mechanical Engineering

The National Institute of Engineering, Mysore

M.Tech – Nanotechnology

Dept. of Mechanical Engineering 1

PREFACE

Dear Students,

The National Institute of Engineering (NIE) was started in the year 1946, a year before

India‘s independence. The Board of Directors is always promoting continuous improvement in

delivery of technical education. The quality factors considered to sustain and grow as a top-

ranking institution are: Faculty Development Programme, Infrastructure, Continuing Education

System, Consultancy and Research. The concerted effort of stake holders at NIE has made it

get autonomous status, grants under prestigious TEQIP-I & II (Technical Education Quality

Improvement Program of World Bank-MHRD) and get accreditation from National Board of

Accreditation, New Delhi. NIE is one of the only two colleges in Karnataka that has been

granted permanent affiliation by VTU for all its courses.

Today NIE boasts of 7 UG, 10 M.Tech and 5 post graduate diploma programmes, and

13 Center of Excellence with overall student strength of over 3000. NIE‘s journey to excellence,

with the main objective of continuous improvements of administrative and academic

competence, is envisioned in reference to three major pillars: intellectual infrastructure,

courses/services offering and institution building.

From the academic year 2014-15 there is a slight change in the syllabus structure and

question paper pattern. This change is due to the philosophy of Outcome Based Education and

requirement as per the National Board of Accreditation (NBA), Government of India, New Delhi.

Sixteen countries including New Zealand, Australia, Singapore, Russia and India are the

signatories of the Washington Accord, which has come out with the new process of

accreditation. This would enable every institution, including NIE to attain high standards of

technical education in the respective countries and to create level playing ground. The outcome

based education is one of the important components of NBA.

NIE is making sincere efforts in meeting the global standards through new formats of

NBA and timely World Bank-MHRD initiative TEQIP (Technical Education Quality Improvement

Program). Efforts are being made to revise the syllabi regularly to meet the challenges of the

current technical education.

.

Dr. B. K. Sridhara August 2014

Dean (Academic Affairs)



NATIONAL INSTITUTE OF ENGINEERING

VISION

NIE will be a globally acknowledged institution providing value based technological &

educational services through best-in-class people and infrastructure

DEPARTMENT OF MECHANICAL ENGINEERING

VISION

Moulding students of Mechanical Engineering with clear concepts and practical

knowledge by imparting value based education for overall development as competent

engineers.

MISSION

The Mechanical Engineering Department is committed to:

Provide a strong foundation in mechanical engineering to make our engineers

globally competitive.

Inculcate creativity and passion to develop innovative solutions to engineering

problems.

Creating centres of Excellence to provide faculty and students with opportunities

to strengthen their training research and leadership skills.

Build relationships with globally acknowledged academic institutions and

Industries in India & abroad to enhance our teaching and research proficiency.



GRADUATE ATTRIBUTES

1. Engineering Knowledge

2. Problem Analysis

3. Design/Development of Solutions

4. Conduct Investigations of complex problems

5. Modern tools usage

6. Engineer and Society

7. Environment and Sustainability

8. Ethics

9. Individual & Team work

10. Communication

11. Project management & Finance

12. Lifelong learning

PROGRAMME EDUCATIONAL OBJECTIVES

Graduates will have successful careers as engineers in the multidisciplinary field of

Nanotechnology

Graduates will be able to pursue advanced studies and involve in a process of lifelong

learning.

Graduates will address societal problems professionally, ethically with due attention to

environmental issues.



PROGRAMME OUTCOMES

At the completion of two year post-graduate program, the students of Nano Technology are

expected to acquire the abilities to:

Apply knowledge and skills to solve complex technical problems which calls for insight

into the latest technologies and best engineering practices

Exhibit critical thinking and articulate effectively with clarity and able to demonstrate

good oral and written communication skills

Study research needs and trends and carry out literature review, research design, analyses

and interpretations in order to draw meaningful conclusions

Provide solutions to varied engineering problems by interpretation of data using modern

computational tools.

Function competently as an individual and as a part of multi-disciplinary teams.

Good understanding of professional and ethical responsibility

Ability to find solutions to engineering problems to cater to the needs of the society.

Discharge professional and ethical responsibility considering societal health and safety.

Exhibit professionalism by employing modern project management and financial tools.

Possess the knowledge of contemporary issues and ability to engage in life-long learning



BLUEPRINT OF SYLLABUS STRUCTURE AND QUESTION PAPER PATTERN

(To be effective from the odd semester of the academic year 2014-15 for all semester students)

Blue Print of Syllabus Structure

1. Complete syllabus is prescribed in SIX units as Unit 1, Unit 2, etc.

2. In each unit there is one topic under the heading ―Self Learning Exercises‖ (SLE). These

are the topics to be learnt by the student on their own under the guidance of the course

instructors. Course instructors will inform the students about the depth to which SLE

components are to be studied. Thus there will be six topics in the complete syllabus which

will carry questions with a weightage of 10% in SEE only. No questions will be asked on

SLE components in CIE.

Blue Print of Question Paper

1. Question paper will have seven full questions.

2. One full question each of 15 marks (Question No 1, 2, 3, 4, 5 and 6) will be set from each

unit of the syllabus. Out of these six questions, two questions will have internal choice from

the same unit. The unit in which choice is to be given is left to the discretion of the course

instructor.

3. Question No 7 will be set for 10 marks only on those topics prescribed as “Self Learning

Exercises”.

Dr. B. K. Sridhara July 2014

Dean (Academic Affairs)



THE NATIONAL INSTITUTE OF ENGINEERING


I SEMESTER

Sl.

No.

Subject

Code Title

Teaching Hrs / Week

Credits L T P

1 APM0401 Applied Mathematics 4 0 0 4

2 MNT 0501 Quantum Mechanics 4 2 0 5

3 MNT0502 Nanoscience & Nanomaterials 4 0 2 5

4 MNT0503 Synthesis and Characterization

Techniques 4 0 2 5

5 MNT05XX Elective I 4 2 0 5

6. MNT04XX Elective II 4 0 0 4

MNT0101 Seminar 0 0 2 1

SEE 29

Elective I Elective II

MNT0509 Advanced Material Science MNT0402 Nanotechnology for Energy

and Environment

MNT0510 Biosafety And Hazards of Nano

Materials MNT0403

Composite Materials And

Applications

MNT0511 Micro and Nano Fluidics MNT0404 Quantum Computing



II SEMESTER

Sl.

No.

Subject

Code Title

Teaching Hrs / Week Credits

L T P

1 MNT0504 Carbon Nanostructures and Applications 5 0 0 5

2 MNT0505 Nanoelectronics 4 2 0 5

3 MNT0506 Nanomaterials, Surface Interface and

Catalysis 5 0 0 5

4 MNT0507 Nanosensors and devices 5 0 0 5

5 MNT04XX Elective III 4 0 0 4

6 MNT04XX Elective IV 4 0 0 4

7 MNT0102 Seminar 0 0 2 1

SEE 29

Elective III Elective IV

MNT0405 Entrepreneur Development & Project

Management MNT0408 Rapid-Prototyping

MNT0406 Nanotechnology and Industrial

Applications MNT0409 Nanobiotechnology

MNT0407 Nanotechnology and Drug Delivery

Systems MNT0410

Nanotechnology in Food and

Agriculture



III SEMESTER

Sl.

No.

Subject

Code Title

Teaching Hrs

/ Week Credits

L T P Credits

1 MNT0401

Internship for 8 Weeks duration (At the end of the

internship, students are required to submit a report and

present a seminar)

- - - 4

2 MNT0801

Project Work (preliminary)

(Students have to initiate the project work and at the end

of the semester should present a progress seminar)

- - - 8

3 MNT0201 Seminar 0 0 0 2

SEE - - - 14

IV SEMESTER

Sl.

No.

Subject

Code Title

Teaching

Hrs

L T P Credits

1 MNT2801

Project Work (Students have to submit the final project

report at the end of the semester which will be evaluated

followed by a seminar presentation and viva – voce

examination)

- - - 28

SEE - - 28

Credit Structure

Core Courses 39

Elective Courses 17

Seminars/Indl Training/preliminary project 16

Major Project 28

SEE 100



APPLIED MATHEMATICS

Sub Code : APM0401 CIE : 50% Marks

Hrs/ Week : 04 SEE : 50% Marks

SEE Hrs. : 52 Exam Marks: 100

Course Outcome:

1. Obtain roots of algebraic and transcendental equations using various numerical

methods.

2. Obtain complex roots of quadratic factors of the given polynomial using iterative

methods.

3. Apply quadrature formulae to solve application problems.

4. Solve linear algebraic equations using direct and iterative methods.

5. Obtain Eigen values and Eigen vectors using iterative methods

6. Establish the homomorphism between vector spaces using Linear transform and

obtain orthonormal basis and solve some application problems using the definition of

inner product space

1. Linear Algebra: Definition of a matrix, types of matrices, matrix operations

such as addition, subtraction, scalar and vector multiplication, matrix characteristics like

rank, transpose, trace, determinant, inverse of a matrix: identity matrix method and

cofactor method of finding the inverse of a matrix, rules for binary operations, unary

operation, Eigen values and Eigen vectors, linear systems of equations, solutions of

linear equations by Gauss elimination and Cramer‘s rule. 7 Hours

2. Numerical Solutions of Algebraic and Transcendental Equations: Fixed Point

Iteration, Bisection Method, False Position or Regular Falsi Method, Newton-Raphson

Method, Secant Method, Muller's Method, improved Newton Method. 6 Hours

3. System of Equations: Simultaneous equations in matrix form, consistency of

equations, types of solutions, methods of solving simultaneous equations: Gauss

elimination method, Gauss-Siedel method, Inverse matrix method, Giraff‘S root square

method, determinant method, Triangular Systems and Back Substitution, Gauss-Jordan

Elimination and Pivoting, Tri-Diagonal Matrices, Inverse Matrix, LU Factorization,

Cholesky, Jacobi, Pivoting Methods, Iterative Refinement, Linear Programming-

Simplex Method. 7 Hours

4. Eigen Value Problems: Definition, Eigen values and Eigen vectors, Theorems of

Eigen values and Eigen vectors, methods of solving Eigen value problems:

Characteristic equation method, Iterative method. Some applications of Eigen value

problem. 7 Hours

5. Orthogonality and Least Squares: Inner product, length and orthogonality,



orthogonal sets, Orthogonal projections, The Gram-schmidt process, Least Square

problems, Inner product spaces. 6 Hours

6. Curve Fitting: Least Squares Lines, Least Squares Polynomials, Nonlinear

Curve Fitting, Logistic Curve, FFT and Trigonometric Polynomials, Conic Fit, Circle

of Curvature. 6 Hours

7. Solution of Ordinary Differential Equations: Euler's Method, Taylor Series Method,

Runge-Kutta Method, Runge-Kutta-Fehlberg Method, Adams-Bashforth-Moulton

Method, Milne-Simpson's Method, Predictor-Corrector Methods, Galerkin's Method.

6 Hours

8. Numerical Integration: Midpoint Rule, Newton-Cotes Integration, Trapezoidal

Rule for Numerical Integration, Simpson's Rule for Numerical Integration, Simpson's 3/8

Rule for Numerical Integration, Adaptive Simpson's Rule, Gauss-Legendre

Quadrature, Cubic Spline Quadrature, Monte Carlo Pi, Monte Carlo Integration, 2D

Trapezoidal and Simpson Rules. 7 Hours

Text Books:

1) Steven C.Chopra, Raymond P.Canale ―Numerical Methods for Engineers‖, 4th Edition, Tata McGraw Hill. 2) Pervez Moin ―Application of Numerical methods to Engineering‖. 3) David. C. Lay, ―Linear Algebra and its Applications‖ -3rd Edition, Pearson Education.

Reference Books:

1) M K. Jain, S.R.K Iyengar, R K. Jain "Numerical Methods for Scientific and Engineering, Computation‖. NEW AGE INTERNATIONAL Publishers.

2) S.S.Sastry ―Numerical Analysis for Engineers‖-Tata Mcgraw Hill Edition.



QUANTUM MECHANICS

Sub Code : MNT0501 CIE : 50% Marks


SEE Hrs. : 52 Exam Marks : 100

Course outcomes

After the successful completion of this course, the student will be able to:

1. Explain basic principle of experiments and interfences which inadequacy of Classical Mechanics.

2. Define the one dimensional extension to three dimensions Eigen value problems. 3. Analyze the different types of Operators and Matrix representation of Operator 4. Construct, develop and interpret X bar and R and S control charts. 5. Draw and interpret the WKB method application to barrier penetrtion 6. Discuss Scattering amplitude problems.

Unit-1 Physical basis of quantum mechanics: Experimental background, inadequacy of classical physics, summary of principle experiments and inferences, Uncertainty and complementarity. Self Learning Exercises (SLE): Wave packets in space and time, and their physical significance.

06 Hours Unit-2 Schrodinger wave equation: Development of wave equation: One-dimensional and extension to three dimensions inclusive of forces. Some exactly soluble Eigen value problems-One dimensional: Square well potentials

Self Learning Exercises (SLE): Interpretation of wave functions: Statistical interpretation, normalisation, expectation value.

08 Hours Unit 3: Quantum mechanics of free particles: confined to 1, 2 and 3D box. Quantum mechanics of free particles confined to a ring and surface of a sphere. Quantum mechanics of a free particle confined to a spherical trap.

Self Learning Exercises (SLE): Electron energy bands in solids: conductors, insulators and semiconductors

10 Hours Unit-4: General formalism of quantum mechanics

Hilbert space. Operators-definition and properties, Eigen values and Eigen vectors of an

operator; Hermitian, unitary and projection operators, commuting operators, complete



set of commuting operators. Bra and Ket notation for vectors. Representation theory:

matrix representation of an operator,

Self Learning Exercises (SLE): change of basis. Co-ordinate and momentum

representations.

10 Hours

UNIT-5: Approximation methods for stationery states: Time-independent perturbation theory; non-degenerate and degenerate cases perturbed harmonic oscillator.

Self Learning Exercises (SLE): WKB method: Application to barrier penetration

08 Hours Unit-6: Theory of scattering: Scattering cross-section, wave mechanical picture of scattering, scattering amplitude. Born approximation.

Self Learning Exercises (SLE): optical theorem; exactly soluble problem- scattering by square well potential

10Hours Text Books:

1. Text book of Quantum Mechanics: P. M. Mathews and K. Venkateshan (TMH, 1994).

2. Quantum Physics of Atoms, molecules, solids Nuclei and particles 2nd Ed by Eisberg, Robert, Resnick Robert.

3. B. Rogers, S. Pennathur and J. Adams, Nanotechnology: Understanding small

systems CRC press 2008



NANOSCIENCE AND NANOMATERIALS




Course outcomes


Explain the history, background and the nature of the Nanoscience and technology as well as the quantum and nanosized scale effects at nano scale level.

Define the different type of nanostructures, top down and bottom up approach for nano scale device preparation.

Elucidate different properties of nanomaterials such as optical, mechanical, electrical, magnetical etc.

Explain the functionality of nanostructures and their characteristic evaluation, self assembly and its application towards controlling the structure.

Recognize the surface modification of nanoparticles by surface modification and their application.

Discuss the different smart materials like thermoresponsive, piezoelectric electrostrictive and biomimetic materials, smart gel, shape memory and their application towards product formation.

1. Introduction to nanoscience and nanotechnology, history, background scope and

interdisciplinary nature of nanoscience and nanotechnology, scientific revolutions,

nanosized effects surface to volume ratio, atomic structure, molecules and phases,

energy at the nanoscale molecular and atomic size, quantum effects, types of

nanotechnology and nano machines. 8 Hours

Self Learning Exercise (SLE) - Scientific revolutions, Nanosized effects

2. Classification of nanostructures - Zero dimensional, one-dimensional and two

dimensional nanostructure materials - semiconductors, ceramics and nanocomposites,

size dependent phenomena, quantum dots, nanowires, nanotubes, nanosheets, nano

and mesopores, top down and bottom up approach, misnomers and misconception of

nanotechnology, importance of nanoscale materials and their devices 8 Hours

Self Learning Exercise (SLE) - importance of nanoscale materials and their devices

3. Properties of Nanomaterials: - Mechanical properties - Thermo physical properties

- Electric properties - Electrochemical properties - Magnetic properties - Optical



properties – Catalytic property - Properties of gas permeation and separation

membranes. 6 Hours

Self Learning Exercise (SLE) - Properties of gas permeation and separation

membranes

4. Nanostructured design: Functionality of nanostructures and their characteristic

evaluation, Size effect in semiconductor nanoparticles- Particle size, shape density -

Melting point, surface tension, wettability - Specific surface area and pore - Assembly

of nanoparticles and functionalization - Nanoparticles arranged structures as Nanopores

and Nanocomposites - Structure control of nanoparticle collectives by sintering and

bonding - Self-assembly. Nanoparticle dispersion and aggregation behavior -

Interactions between particles - Aggregation and dispersion and characterization.

10 Hours

Self Learning Exercise (SLE) - Nanoparticle dispersion and aggregation behavior

5. Surface modification of Nanoparticles: Surface modification of inorganic

nanoparticles by organic functional groups - Instantaneous nanofoaming method for

fabrication of closed-porosity silica particle- Development of photocatalyst inserted into

surface of porous aluminosilicate - Dispersion control of nanoparticles in solvents -

Development of biodegradable PLGA nanospheres and application. 10 Hours

Self Learning Exercise (SLE) - Development of biodegradable PLGA nanospheres

and application

6. Smart Materials and Systems: Thermoresponsive materials, piezoelectric materials,

electrostrictive and magnetostrictive materials, ER and MR fluids, biomimetic materials,

smart gel, shape memory alloys and polymers, actuation methods, measurements.

Applications of quantum dots for bio medical applications 10 Hours

Self Learning Exercise (SLE) - piezoelectric materials

Text Books

1. Edward L. Wolf, "Nanophysics and Nanotechnology - An Introduction to Modern Concepts in Nanoscience" Second Edition, John Wiley & Sons, 2006. 2. K.W. Kolasinski, ―Surface Science: Foundations of Catalysis and Nanoscience‖, Wiley, 2002. 3. G.A. Ozin and A.C. Arsenault, ―Nanochemistry : A chemical approach to nanomaterials‖, Royal Society of Chemistry, 2005. 4. Nanostrucrues and Nanomaterials synthesis, properties and applications, G. Cao, Imperaial college press 2004.



References

1. Vladimir P. Torchilin (2006) Nanoparticulates as Drug Carriers, Imperial College Press. 2. M. Reza Mozafari (2007) Nanomaterials and Nanosystems for Biomedical Applications, Springer. 3. Nanotechnology – Basic Science & Emerging Technologies, Chapman & Hall/CRC 2002 4. Nanomaterials Nanotechnologies and Design: An introduction for engineers and architects, Micheal F. Ashby, P.J. Ferreria, D.L.Schodek.



SYNTHESIS AND CHARACTERISATION TECHNIQUES





1. Fabricate/synthesize nanostructures by either approach. 2. Discuss various physical methods of synthesis of nanomaterials. 3. Enunciate various chemical methods of synthesis of nanomaterials. 4. Discuss various biological methods of synthesis of nanomaterials and their

mechanisms of formation. 5. Develop nanostructures on substrates and pattern them to desired shape using

lithographical etching techniques. 6. Study of structure, composition and analysis of synthesized nanomaterials by

various characterization techniques.

1. Introduction: Synthesis and nanofabrication, Bottom-Up versus Top-Down; Top-down approach with examples. 4 Hours Self Learning Exercises (SLE): Nanofabrication 2. Physical Methods: Ball milling synthesis, Arc discharge, RF-plasma, Plasma arch technique, Inert gas condensation, electric explosion of wires, Ion sputtering method, Laser pyrolysis, Molecular beam epitaxy and electrodeposition. Electro spinning, Physical vapor Deposition (PVD) – Chemcial vapour Deposition (CVD) - Atomic layer Deposition (ALD) – Self Assembly- LB (Langmuir-Blodgett) technique. 8 Hours Self Learning Exercises (SLE): Physical Vapour Deposition 3. Chemical methods: Chemical precipitation methods- co-precipitation, arrested precipitation, sol method, chemical reduction, photochemical synthesis, electrochemical synthesis, Microemulsions or reverse micelles, Sonochemical synthesis, Hydrothermal, solvothermal, supercritical fluid process, solution combustion process, spray pyrolysis method, flame spray pyrolysis, chemical vapor synthesis, gas phase synthesis, gas condensation process, chemical vapor condensation. Fundamental aspects of VLS (Vapor-Liquid-Solid) and SLS (Solution-Liquid-Solid) processes – VLS growth of Nanowires – Control of the size of the nanowires – Precursors and catalysts – SLS growth – Stres induced recrystalization. 13 Hours Self Learning Exercises (SLE): Microemulsions and reverse micelles



4. Biological methods: Use of bacteria, fungi, Actinomycetes for nanoparticle

synthesis, Magnetotactic bacteria for natural synthesis of magnetic nanoparticles;

Mechanism of formation; Viruses as components for the formation of nanostructured

materials; Synthesis process and application, Role of plants in nanoparticle synthesis.

7 Hours

Self Learning Exercises (SLE): Actinomycetes for nanoparticle synthesis

5. Photolithography: Nanomanipulation and Nano lithography – Soft Lithography – E

beam lithography and SEM based nanolithography and nanomanipulation, Ion beam

lithography- Oxidation and metallization - Mask and its application - Deep UV

lithography. Assembly of Nanoparticles and Nanowires – Sol gel Lithography.

6 Hours

Self Learning Exercises (SLE): Sol gel Lithography

6. Characterization Techniques: Introduction, Structural and compositional

characterization-principles and applications of X-ray diffraction, X-ray photoelectron

spectroscopy, Energy dispersive X-ray analysis, electron diffraction. Principles and

applications of Scanning electron microscopy, transmission electron microscopy, atomic

force microscopy, scanning tunneling microscopy, microstructure studies and analysis.

Nano size measurement by light scattering methods

Self Learning Exercises (SLE): Nano size measurement by light scattering methods

14 Hours

Text Books

1. Nanochemistry: A chemical approach to Nanomaterials Roayal Society of Chemistry,

Ozin and Arsenault, Cambridge UK 2005,

2. Nanoparticles: From Theory to Applications, G.Schmidt, Wiley Weinheim 2004.

3. Characterization of Nanostructure materials by XZ.L.Wang

References

1. Guozhong Cao, ―Nanostructures and Nanomaterials, synthesis, properties and

applications”, Imperial College Press, 2004.

2. T. Pradeep , ―NANO The Essential , understanding Nanoscience and

Nanotechnology”. Tata McGraw-Hill Publishing Company Limited, 2007.



3. C.A. Mirkin and C.M. Niemeyer, Nanobiotechnology- II, More Concepts and

Applications, WILEY-VCH, Verlag Gmb H&Co, 2007.

4. David G. Bucknall. Nanolithography and patterning techniques in microelectronics,

CRC Press,

5. Electron Microscopy and analysis by P.J.Goodhew and F.J.Humpreys

6. Scanning electron microscopy and X-ray microanalysis by J.I.Goldstein

Lab Component:

1. Synthesis of Gold/Silver nanoparticles 2. Synthesis of CdS nanoparticles 3. Thin film fabrication by Sputtering 4. Thin film fabrication by thermal evaporation 5. Characterization by AFM 6. Characterization by XRD 7. Characterization by SEM



ADVANCED MATERIAL SCIENCE




___________________________________________________

Course outcomes


1. Explain the crystal system and unit cell, reciprocal lattice and X-ray diffraction methods. 2. Elucidate the types of binding, different forces acting on atoms and molecules,

quantization of lattice vibrations and specific heat of lattice. 3. Discuss the formation of energy bands, free electrons in potential well, Fermi energy,

point and plane defects. 4. Discuss the kinds of semiconductors, electrical conductivity, Hall effect and four probe

method. 5. Explain the Boltzmann equation, Electrical conductivity and general transport properties. 6. Define the thermal conductivity, magnetic effects, acoustic and optical scattering by

electron.

1. Crystal structure: Crystal systems, Crystal classes, Bravais lattice. Unit cell:

Wigner-Seitz cell, equivalent positions in a unit cell. Notations of planes and directions.

Atomic packing: packing fraction, Co-ordination number. Symmetry operations, point

groups and space groups. X-ray diffraction: - X-ray diffraction, Bragg law. Concept of

reciprocal lattice. Experimental diffraction methods: Rotating crystal method and

Powder method. 8 Hours

Self Learning Exercise (SLE) - Concept of reciprocal lattice

2. Crystal binding: Types of binding, Van der Waals-London interaction, Repulsive

interaction. Modelung constant. Born‘s theory for lattice energy in ionic crystals and

comparison with experimental results. Ideas of metallic binding, Hydrogen bonded

crystals. Lattice vibrations: - Vibrations of monoatomic lattices. First Brillouin zone.

Quantization of lattice vibrations - Concept of Phonon, Phonon momentum. Specific

heat of lattice (qualitative). 10 Hours

Self Learning Exercise (SLE) - Vibrations of monoatomic lattices. First Brillouin zone



3. Energy bands in solids: Formation of energy bands. Free electron model: free

electrons in one and three dimensional potential wells, electrical conductivity, heat

capacity, paramagnetism, Fermi-Dirac distribution, density of states, concept of Fermi

energy. Kronig-Penny model. Nearly Free Electron Model (qualitative). Tight Binding

model (qualitative). Defects in solids: Point defects: Schottky and Frenkel defects and

their equilibrium concentrations. Plane defects: grain boundary and stacking faults.

10 Hours

Self Learning Exercise (SLE) – Plane defects: grain boundary and stacking faults

4 Semiconductors: Intrinsic and extrinsic semiconductors, concept of majority and

minority carriers. Statistics of electrons and holes, electrical conductivity. Hall effect.

Experimental determinations of resistivity of semiconductor by four probe method.

8 Hours

Self Learning Exercise (SLE) – Electrical conductivity. Hall effect

5. Transport properties of metals: Boltzman equation, Electrical conductivity,

Calculation of relaxation time. Impurity scattering, Ideal resistance. General transport

coefficients, Thermal conductivity, Thermoelectric effects, Lattice conduction, Phonon

drag. 8 hours

Self Learning Exercise (SLE) – Thermal conductivity, Thermoelectric effects

6. Transport properties of semiconductors: Thermal conductivity. Thermoelectric

and magnetic effects. Hot electron and energy relaxation times. High frequency

conductivity. Acoustic (deformation and piezoelectric) and optical (polar and non polar)

scattering by electrons. 8 hours

Self Learning Exercise (SLE) – Acoustic (deformation and piezoelectric) scattering by

electrons.

Text Books

1. Introduction to Solid State Physics, C. Kittel, Wiley Eastern

2. A practical approach to X-Ray diffraction analysis by C.Suryanarayana

3. Semiconductor Physics, P. S. Kireev, MIR Publishers.

4.

References

1. Solid State Physics, A. J. Dekkar, Prentice Hall Inc.



2. Introduction to Superconductivity, M. Tinkham, McGraw-Hill, International

Editions

3. Elementary Solid State Physics: Principles and applications, M. A. Omar,

Addison-Wesley.



BIOSAFETY AND HAZARDS OF NANO MATERIALS




______________________________________________________________

Course Outcomes

After the successful completion of this course, the student will be able to

1. Identify different types of nano materials and its applications.

2. Explain problems and issues of Bio nano materials.

3. Understand the patent of research article.

4. Define the safety and handling of nano materials

5. Describe the toxic and hazards of Nanomaterials

6. Discuss the experimental issues of Nano materials.

Unit-1Introduction: Properties of nanomaterials, Interactions between biomolecules

and nanoparticles surface, different types of materials used for the synthesis of hybrid

nano-bio assemblies, applications of nano in biology, nanoprobes for clinical

biotechnology.

Self Learning Exercise (SLE): Nanomaterials and their applications in agriculture,

environment and medicine. 8 Hours

Unit-2 Bioethics: Introduction to Bioethics. Social and ethical issues in Biotechnology.

Definition of Biosafety. Biosafety for human health and environment. Social and ethical

issues. Use of genetically modified organisms and their release in to the environment.

Self Learning Exercise (SLE): Special procedures for r-DNA based products using

nanomaterials. 8 Hours

Unit-3 Patenting: Invention in context of ―prior art‖; Patent databases; Searching

International Databases; Country-wise patent searches (USPTO, EPO, India etc.);

Analysis and report formation, International patenting-requirement, procedures and

costs; Financial assistance for patenting-introduction to existing schemes; Publication of

patents-gazette of India, status in Europe and US Patenting by research students,

lecturers and scientists-University/organizational rules in India and abroad, credit

sharing by workers, financial incentives,



Self Learning Exercise (SLE):Patent infringement- meaning, scope, litigation, case

studies and examples. 12 Hours

Unit-4 Biosafety: Introduction; Historical Backround; Introduction to Biological Safety

Cabinets; Primary Containment for Biohazards; Biosafety Levels; Biosafety Levels of

Specific Microorganisms; Recommended Biosafety Levels for Infectious Agents and

Infected Animals; Biosafety guidelines - Government of India; Risk management and

communication; Overview of National Regulations and relevant International

Agreements including Cartagena Protocol. Identification of nano specific risks –

responding to challenge- human health hazard–risk reduction-standards–safety–

transportation of the nanoparticles–emergency responders. Risk assessment related to

nanotechnology-environmental.

Self Learning Exercise (SLE): policy making – eco toxicity measurement of

polychlorinated biphenyl and intermediates in their degradation. 12 Hours

Unit-5 Nanotoxicology: Inhalation of nano materials–overview. Introduction Inhalation

– deposition and pulmonary clearance of insoluble solids- bio–persistence of Inhaled

solid material. Systemic translocation of inhaled particles .pulmonary effects of

SWCNT–pulmonary inflammatory Reponses to SWCNT. In vivo – interaction of the

pulmonary inflammation with oxidative stress–interactions of SWCNTs with macro

phages.

Self Learning Exercise (SLE): Toxicological assessment of nanoparticles: Hazard

identification, hazard characterization, exposure assessment and risk calculation.

12 Hours

Unit-6. Experimental issues: Nano particle exposure and systematic cardiovascular

effects – experimental data–respiratory particulate matter exposure and cardiovascular

toxicity, nano particles–hypothesis and research approaches. SWCNT-experimental

data. Toxicity of polymeric nano particles with respect to and their applications as drug

carriers.

Self Learning Exercise (SLE): Particle exposure through the indoor air environment –

Measurement of indoor PM and experimental study.

8 Hours

Text Books

1.J. B Park, ―Biomaterials Science and Engineering‖, Plenum Press, New York, 1984.



2.P.P. Simeonova, N. Opopol and M.I. Lus ter, ―Nanotechnology - Toxicological Issues

and Environmental Safety‖, Springer 2006.

3.Vinod Labhasetwar and Diandra L. Leslie, ―Biomedical Applications of

nanotechnology‖, A John Willyv& son Inc, N.J, USA, 2007 .

References

1.J.J. Davis, Dekker, ―Encyclopedia of Nanoscience and nanotechnology‖

2.Hutchison, J. E. Green Nanoscience: A Proactive Approach to Advancing Applications

and Reducing Implications of Nanotechnology. ACS Nano 2, (395–402) 2008.

3.Dracy J. Gentleman, Nano and Environment: Boon or Bane? Environmental Science

and technology, 43 (5), P1239, 2009



MICRO AND NANO FLUIDICS




Course outcomes


1. Understand the basics of Micro and nanofludics.

2. Analyze and apply different techniques such as liquid flows, capillary flow and

electro-Kinetically driven liquid micro flows.

3. Describe the Laminar flow of micro fluidics and case studies.

4. Define the ionic transport of micro fluidic particles.

5. Explain the fabrication techniques of Nano fluidic channels.

6. Identify the Particle moving in flow fields

Unit-1 Introduction: Fundamentals of kinetic theory-molecular models, micro and

macroscopic properties, binary collisions, distribution functions, Boltzmann equation and

Maxwellian distribution functions-Wall slip effects and accommodation coefficients, flow

and heat transfer analysis of microscale Couette flows,

Self Learning Exercises (SLE): Pressure driven gas micro-flows with wall slip effects,

heat transfer in micro-Poiseuille flows, effects of compressibility.

12 Hours

Unit-2 Pressure driven liquid microflow: apparent slip effects, physics of near-wall

microscale liquid flows, capillary flows, electro-kinetically driven liquid micro - flows and

electric double layer (EDL) effects,

Self Learning Exercises (SLE): concepts of electroosmosis, electrophoresis and

dielectro-phoresis.

10Hours

Unit-3 Laminar flow: Hagen-Poiseullie eqn, basic fluid ideas, Special considerations of

flow in small channels, mixing, microvalves & micropumps, Approaches toward

combining living cells, microfluidics and ‗the body‘ on a chip, Chemotaxis, cell motility.

Self Learning Exercises (SLE): Case Studies in Microfluidic Devices.

12 Hours



Unit-4 Ionic transport: Polymer transport – microtubule transport in nanotuble

channels driven by Electric Fields and by Kinesin Biomolecular Motors –

Self Learning Exercises (SLE): Electrophoresis of individual nanotubules in

microfluidic channels.

8 Hours

Unit-5 Fabrication techniques for Nanofluidic channels – Biomolecules separation

using Nanochannels - Biomolecules Concentration using Nanochannels – Confinement

of Biomolecules using Nanochannels.

Self Learning Exercises (SLE): Potential Functions in Low Renoylds Number Flow –

Arrays of Obstacles and how particles Move in them: Puzzles and Paradoxes in Low Re

Flow.

10 Hours

Unit-6. Hydrodynamics: Particle moving in flow fields – Potential Functions in Low

Renoylds Number Flow – Arrays of Obstacles and how particles Move in them:

Self Learning Exercises (SLE): Puzzles and Paradoxes in Low Re Flow.

6 Hours

Text Books

1. Joshua Edel ―Nanofluidics‖ RCS publishing, 2009. 2. Patric Tabeling ―Introduction to Microfluids‖ Oxford U. Press, New York 2005. 3. K. Sarit ―Nano Fluids; Science and Technology‖, RCS Publishing, 2007.

References

1. M. Madou, Fundamentals of Microfabrication, CRC Press, 1997 2. G. Kovacs, Micromachined Transducers, McGraw-Hill, 1998 3. Steven S Saliterman, Fundamentals of BioMEMS and Medical Microdevices, 2006



NANOTECHNOLOGY FOR ENERGY AND ENVIRONMENT




Course outcomes


1. Understand the basic and essential elements of Thermodynamics 2. Explain the different types of solar cells. 3. Discuss the different types of Energy storage devices. 4. Define the working principle of Super capacitors 5. Describe the working principle and applications of Fuel cells 6. Identify environmental and safety issues in nanomaterials.

Unit-1 Fundamentals of thermodynamics: Chemistry and transport applied to energy

systems. Analysis of energy conversion and storage in thermal, mechanical, chemical

Self Learning Exercises (SLE): electrochemical process in power and transportation

systems, with emphasis on efficiency, performance, and environmental impact.

06 Hours

Unit-2 Renewable energy Technology: Energy challenges, nanomaterials and

nanostructures in energy harvesting, solar cell structures: quantum well and quantum

dot solar cells, thin film solar cells, CIGS solar cells, Dye sensitized solar cells.

Self Learning Exercises (SLE): Organic PV cells

08 Hours

Unit-3 Energy storage: Introduction, Battery types, Li-ion Battery, Battery components

materials, cathodes, anodes, effect of nanosize on energy storage and electrode

materials performance.

Self Learning Exercises (SLE): LIB for automobiles application, EV‘s, HEV, PHEV and

power grid.

10 Hours

Unit-4 Super capacitors: Introduction, Electrochemical energy storage,

electrochemical capacitors, Electrochemical double layer capacitor, electrode materials



supercapacitors,

Self Learning Exercises (SLE): Electrolytes for super capacitors, types of electrolytes.

10 Hours

Unit-5 Fuel cell technology: Fuel cell principles, types of fuel cells (Alkaline

Electrolytie, phosphoric acid, Molten carbonate, solid oxide and direct methanol and

proton exchange fuel cells), Principle and operation of proton exchange membrane

(PEM) fuel cell, materials and

Self Learning Exercises (SLE): fabrication methods for fuel cell technology, micro fuel

cell power sources-biofuels.

10 Hours

Unit-6Environmental and Safety issues: Nanoparticles and environment -

Nanoparticles in atmospheric environment, Indoor environments Industrial processes

and nanoparticles ; Safety of nanoparticles- Problems caused by nanoparticles

Self Learning Exercises (SLE): Health effects on nanoparticles - Safety assessment

for the nanoparticles. 10 Hours

Text Book

1. D. Linden, Handbook of Batteries and Fuel Cells, Mcgraw-Hill, Noew York,1984 2. W. A. van Schalkwijk and B. Scrosati, Advances in Lithium- Ion Batteries, Kluwer Academic Publishers, Newyork, 2002 3. Linden , D. and Reddy , T.B. ( 2002 ) Handbook of Batteries , 3rd edn , McGraw - Hill , New York.

Reference

1. Crompton, T.R. ( 2000 ) Battery Reference Book , 3rd edn , Newnes , Oxford . 2. K. E. Aifantis and S. A. Hackney and R. Vasant Kumar, High Energy Density Lithium Batteries, Wiley-VCH Verlag, 2009. 3. University of Cambridge (2005) DoITPoMS Teaching and Learning Packages,http://www.doitpoms.ac.uk/tlplib/batteries/index.php (accessed 5 February 2010)



COMPOSITE MATERIALS AND APPLICATIONS




______________________________________________________________


1. Discuss various properties of nanocomposites and study mechanical properties of

super hard nanocomposites.

2. Gain experimental knowledge on various synthesis of nanocomposites and

modelling.

3. Process and nucleation study of polymer based nanocomposites.

4. Study and replacement of artificial natural composites for biological parts of human

body.

5. Understand and develop bio mimetic implant coatings.

6. Apply knowledge of nanocomposites towards commercialization.

1. Introduction to nanocomposites: Advantage of composite materials, mechanical

properties, Thermal, electrical and electronic and optical properties. Super hard

nanocomposites-designing and mechanical properties - stress-strain relationship,

toughness, strength, and plasticity.

Self Learning Exercises (SLE): Optical properties of nano composites

7 Hours

2. Ceramic metal nanocompsites: Ceramic based nanoporous composites, metal

matrix nanocomposites, natural nano-bioccomposites, bio-mimetic nanocompostes and

biologically inspired nanocomposites, nanocompsites for hard coatings, DLC coatings,

thin film nanocomposites, modelling of nanocomposites, synthesis of various

nanocomposites materials, sputtering, mechanical alloying.

Self Learning Exercises (SLE): DLC coatings

8 Hours

3. Polymer nanocomposites: Introduction to polymer composites, Processing of

nanoparticles, binding mechanisms in nanoparticles, dispersion of nanoparticles, and

stabilization of nanoparticles. Processing and fabrication of polymer nanocomposites,

Melt blending, solvent casting, In-situ polymerization, solution polymerazation, template

synthesis, high shear mixing. Homogeneous/heterogenous nucleation, plasma



promoted nucleation. Polymer nanocomposites with structural, gas barrier and flame

retardant properties, carbon fiber reinforced polymer composites, elastomer and

thermoplastic elastomer nanocompostes for propulsion systems, water borne fire-

retardant nanocompostes, hybrid composites for cosmetics, protective and decorative

coatings.

Self Learning Exercises (SLE): In-situ polymerization

9 Hours

4. Natural nanocomposite systems: Spider silk, bones, shells; organic –inorganic

nanocomposite formation through self-assembly. Biomimetic synthesis of

nanocomposite material; use of synthetic nanocomposites for bone teeth replacement.

Bioactive nanocomoposites in bone grafting and tissue engineering, inorganic/polymer

nanocomposites for dental restoration and bone replacement applications.

Self Learning Exercises (SLE): Bone replacement applications.

7 Hours

5. Bio ceramics for implant coating: Calcium phosphates-hydroxy epilates Ti6Al4V

and other biomedical alloys, implant tissue interfacing-metal organic CVD-use of

tricalcium phosphate-biomimetic and solution based processing- osteo porosis- osteo

plastic, regeneration of bones by using bio compatible ceramics, bioninteractive hydro

gels- PEG coating and surface modifications, PEG hydrogels patterned on surfaces-

PEG based hydrogels.

Nanobiocomposites: Cell-substrate interaction, types of Nanomaterials for insitu

composite formation, multifunctional namomaterials as biocompatible and bioactive

components. Nanoscaffolds for tissue engineering- types of nanoscaffolds and

formation techniques; advantages over macro/micro-structured surface ssk

Nanomaterials for enhanced growth and differentiation of nerve cells, stem cells and

osteoblasts.

Self Learning Exercises (SLE): PEG based hydrogels

14 Hours

6. Commercial aspects of nanocomposites: Problem related to technological aspects

of nano composites; Difficulty in Fabrication; Limitation; Advantages, properties;

Application of few commercially available nano composites.

Self Learning Exercises (SLE): Limitations in fabrication of nano composites

7 Hours



Text Books

1. Nanocomposite science and technology by P.M.Ajayan, L.S. Schadler and P.V.

Braun, Wiley-VCH GmbH Co. 2003.

2. Encyclopedia of Nanotechnology by H.S.Nalwa, American Scientific Publishers,

2003.

3. Metalopolymer nanocomposites, Ed A.D. Pomogailo and V.N.Kestelman,

Springer-Verlag, 2005.

References

1. Biomedical nanostructures by Kenneth E.Gonsalves, Craig R. Halberstadt, Cato

T. Laurencin, Lakshmi S. Nair. John-Wiley & Sons, 2008.

2. Nanobiotechnology II: Edited by Chad A. Mirkin and Christof M. Niemeyer, Wiley-

VCH, 2006.

3. Handbook of Biomineralization: Biomimetic and Bioinspired, Chemistry edited by

Peter Behrens, Edmund Bäuerlein John-Wiley Sons, 2006.



QUANTUM COMPUTING





1. Gain facility of some of the many concepts and techniques in second generation

nanotechnology.

2. Understand advanced knowledge on cell repairing and curing using nanotechnology.

3. Use nanoparticles for life extension, quality of life and biostatis requirement.

4. Know the efficient utilization of resources and their limitations.

5. Understand the basic architecture of Engines of Destruction.

6. Should understand foundations of strategies of synthesis for engine survival.

1. Engines of Construction I

Two styles of technology - Molecular technology today - Existing protein machines -

Designing with protein - Second-generation nanotechnology - Universal assemblers -

Nailing down conclusions - Nanocomputers - Disassemblers - The world made new -

The principles of change - Order from chaos - Evolving molecules - Explaining

order.

Engines of Construction II: Evolving organisms - Another route back - The rise

of the replicators - Evolving technology - The evolution of design - The new replicators

- The creatures of the mind - Selecting ideas - Predicting and projecting - Pitfalls

of prophecy - Science and natural law - Science vs. technology - The lesson of

leonardo - The assembler breakthrough.

Self Learning Exercises (SLE): The rise of the replicators

13 Hours

2. Engines of abundance and thinking machines -I

Engines of abundance - Clanking replicators - Molecular replicators - Molecules &

skyscrapers - Thinking machines - Machine intelligence - Turing's target - Engines of

design - The AI race - Accelerating the technology race.

Engines of abundance and thinking machines -II :The world beyond earth - The

new space program - Space and advanced technology - Abundance - The

positive-sum society - Engines of healing - Life- Mind and machines - From drugs to cell

repair machines - Cell repair machines - Some cures - Anesthesia plus - From function



to structure - From treating disease to establishing health - A disease called "Aging".

Self Learning Exercises (SLE): Clanking replicators

13 Hours

3. Long life in an open world and future - I

Cell repair machines - Healing and protecting the earth - Long life and

population pressure - The effects of anticipation - Progress in life extension. - A

door to the future - The requirements for biostasis - Methods of biostasis - Reversing

biostasis.

Self Learning Exercises (SLE): Reversing biostasis

6 Hours

4. Long life in an open world and future –II

Mind - Body and soul - Reactions & arguments - Time - Cost and human action - The

limits to growth - Thestructure of the vacuum - Will physics again be upended - The

limits to hardware - Entropy - A limit to energy use - The limits to resources - Malthus -

Will someone stop us - Growth within limits - Views of limits.

Self Learning Exercises (SLE): Views of limits

7 Hours

5. Engines of Destruction

The threat from the machines - Engines of power -Trustworthy systems - Tactics for the

assembler breakthrough - Is success possible - Strategies and survival - Personal

restraint - Local suppression - Global suppression agreements - Global suppression by

force - Unilateral advance - Balance of power.

Self Learning Exercises (SLE): Trustworthy systems

7 Hours

6. Engines of Survival

Cooperative development - A synthesis of strategies - Active shields vs

space weapons - Power - Evil - Incompetence and sloth - Finding the facts - A

mess of experts - From feuds to due process - An approach - Why not due process -

Building due process.

Self Learning Exercises (SLE): Incompetence and sloth



6 Hours

TEXT BOOK

1. Eric Drexler, "Engines of Creation: The Coming Era of Nanotechnology",

Reprint Edition, Anchor, 1987.



CARBON NANOSTRUCTURE AND APPLICATIONS




Course outcomes


1. Explain the different nanostructures like whiskers, cones and polyhedral crystals and their structure properties and application. 2. Introduce the type of carbon nanotubes and different synthesis methods and growth mechanisms. 3. Elucidate different properties and applications of carbon nanotubes in various fields. 4. Introduce the graphite derivatives, fullerenes and its type, nanodiamond, graphene, different synthesis methods. 5. Definefunctionalization of carbon nanostructures (CNT, Graphene and fullerene) with various inorganic functional groups. 6. Explain the application of carbon nanostructure for different day-to-day applications.Discuss the Nanostructure catalytic materials like Pt, Pd and Fe, colloidal and porous materials. 1. Nanostructures: Graphite, Whiskers, Cones, and Polyhedral crystals, structure, propertiesand applications. 6 Hours Self Learning Exercise (SLE) – Graphite 2. Carbon Nanotubes (CNT): Histroy, types of CNTs, synthesis methods, CVD method, Laser ablation and electric arc processes, growth mechanisms, purification and characterization methods, mechanical reinforcements, solid disordered carbon nanostructures. 8 Hours Self Learning Exercise (SLE) – purification and characterization methods 3. Properties and applications of CNTs: electrical, vibrational, mechanical, optical properties and Raman spectroscopy of CNTS, carbon cluseters, decoration of CNT by nano metals and metal oxides, Applications-Lithium ion battery, fuel cells, hydrogen storage, sensor applications, applications to nanoelectronics, nanocomposites, nanowires an drug delivery. 8 Hours Self Learning Exercise (SLE) – decoration of CNT by nano metals and metal oxides 4. Graphite derivatives: Fullerenes and types, diamond like carbon, nanodiamond, clusters, metal carbide derived carbon nanostructures, synthesis and applications. Graphene:- Background, structure, exfoliation or synthesis methods- physical methods-



micromechanical (scotch tape method), CVD, electric arc process. Chemical approaches-Hammers method, oxidation and reduction of graphite, solvothermal, supercritical fluid, solvent sonication method, chemically modified graphene, electrochemical synthesis and other methods. 10 Hours Self Learning Exercise (SLE) – electrochemical synthesis and other methods 5. Functionalization of carbon nanostructures: (CNT, Graphene and fullerenes)- reactivity, covalent functionalization-oxidative purification, defect functionalization, transformation and modification of carboxylic functionalziation like amidation, thiolation, halogenations, hydrogenation, addition of radicals, sidewall funciontalziation through electorphilic addition, nanocovavlent exohedral funcionlaization, endohedro functionalization. 10 Hours Self Learning Exercise (SLE) – exohedral funcionlaization, endohedro functionalization 6. Carbon nanostructure applications - Lithium ion battery, fuel cells, hydrogen storage, sensor applications, applications to nanoelectronics, nanocomposites, nanowires in drug delivery, polymer reinforcement and as filler materials. 10 Hours Self Learning Exercise (SLE) – nanowires in drug delivery Text Books 1. Carbon Nanotubes: properties and applications-Mchael J. O‘Connell, Taylor & Francis, 2006 2. Nanotubes and Nanowires-CNR Rao and A Govindaraj RSC publishing 3. Handbook of Carbon, Yury Gagotsi, Taylor & Francis, 2006 Reference 1. Physical properties of carbon nanotube- R. Satio 2. Applied physics of Carbon nanotubes: fundamentals of theory, optics and transport devices- S.Subramoney and S.V.Rotkins 3. Carbon nanotechnology-Liming Dai



NANOELECTRONICS




Course Outcomes

After the successful completion of this course, the student will be able to

1. Explain the principles of Semiconductor materials.

2. Discuss the Fabrication of Semiconductor materials.

3. Describe Linear and Non linear Photonic Crystal.

4. Explain the fabrication of photonic crystals and devices

5. Describe the principle and working of plasmincs

6. Characterize the Principle and working of Spintronics

Unit-1 Introduction to electronics: classification of solids, energy levels, intrinsic and

extrinsic semiconductor, conduction in metals and semiconductors. Semiconductor

diodes: Diode under forward bias condition, diode under reverse bias,

Self Learning Exercises (SLE): Transitor basics, working principles of different

transistor I-V characteristic studies and applications.

10 Hours

Unit-2 Semiconductors: Tuning the Band gap of Nanoscale Semiconductors,

Excitons, Semiconductor nanowires- Fabrication strategies, quantum conductance

effects in semiconductor nanowires, porous Silicon, nanobelts, nanoribbons,

nanosprings; Quantum dot

Self Learning Exercises (SLE): Single electron devices, molecular electronic devices;

10 Hours

Unit-3 Photonic crystals: Linear photonics crystals-Maxwell‘s equation, Bloch‘s

theorem, photonic band gap and localized defect states, transmission spectra,

Nonlinear Photonic crystals- 1-D quasi phase matching, nonlinear photonic crystal

analysis.

Self Learning Exercises (SLE): applications of nonlinear photonic crystals devices

08 Hours

Unit-4: Fabrication and application of photonic crystals and devices: choices of



materials, semiconductors, amorphous, and polymers, fabrication of photonic crystals

structures (1-D, 2-D, 3-D). Application: 1-D photonic crystals, Couplers, 2-D photonic

crystals

Self Learning Exercises (SLE): Photonic crystals fibers

6 Hours

Unit-5: Plasmonics: Introduction, merging photonics and electronics at nanoscale

dimensions, single photon transistor using surface Plasmon, nanowire surface

plasmons-interaction with matter, single emitter as saturable mirror, photon correlation,

and integrated systems.

Self Learning Exercises (SLE): Near-field photonics; Surface Plasmon polaritons

10 Hours

Unit-6 Spintronics: Introduction, overview, History and background, Generation of spin

polarization, theories of spin injection, spin relaxation and spin dephasing, spintronic

devices and applications,

Self Learning Exercises (SLE): spin filters, spin diodes, spin transistors.

08 Hours

Text Books:

1. Nanotechnology enabled sensors by Kouroush Kalantar – Zadeh, Benjamin Fry,

Springer Verlag New York, (2007)

2. Steven S. Saliterman, Fundamentals of BioMEMS and Medical Microdevices ,SPIE

Press Monograph Vol. PM153, 2006

3. Biosensors: Oxford University Press, USA; 2 edition, 2004

References

1. W. Ranier, Nano Electronics and Information Technology, Wiley, 2003.

2. K.E. Drexler, Nano systems, Wiley, (1992).

3. M.C. Gupta, J. Ballato The Handbook of Photonics.

4. Nanotechnology for Microelectronics and Optoelectronics, J.M. Martinez-Duart, Raul

J.Martin-Palma,



NANOMATERIALS, SURFACE INTERFACE AND CATALYSIS




______________________________________________________________

Course outcomes


1. Introduce the surface-interface concept and its properties specially surface energy

and their states, and surface tension.

2. Explain the binding of molecules to the surface, physio and chemio adsorptions and their kinetic models, thin films and their properties with epitaxial growth. 3. Discuss the surface interface effects, and its characterization, coating surfaces with thin films. 4. Define surface segregation and self assembly of block copolymer, non lithographic patterning and microcontact printing. 5. Discuss the Nanostructure catalytic materials like Pt, Pd and Fe, colloidal and porous materials. 6. Introduce the mesoporous materials, their synthesis and characterization and applications.

1. Introduction: definitions, Surface energy and surface states, surface tension.

Surface, Interface and Bulk- Surface -Surface electronic structure. 6 Hours

Self Learning Exercise (SLE) – Surface energy, surface tension

2. Surfaces and Interfaces Binding of molecules to the surface, adsorption

phenomenon- chemisorption, and physorptions diffusion, nucleation. Adsorption

isotherms, kinetic model of sorption, potential model of sorption, two-dimensional gas.

Stimulated desorption. Ideal and real surface, surface states. Electron emission,

electron spectroscopy. Interaction of particles and radiation with surface, diffraction,

secondary emission. ion implantation. Surface ionization. Different properties of thin

films and bulk, charge transport through thin films. Epitaxial growth. 10 Hours

Self Learning Exercise (SLE) – Different properties of thin and bulk films

3. Principles of Surface and Interface Chemistry: surface-interface energy and

tension, wetting, characterisation of surfaces and interfaces. Techniques for

Manipulating Surfaces: adsorption of surfactants and macromolecules, physical grafting

of macromolecules (including some common routes for chemical grafting), coating

surfaces with thin films. 10 Hours



Self Learning Exercise (SLE) – physical grafting of macromolecules

4. Structured Coatings: surface segregation and self-assembly in films of blends and

copolymers, films by Langmuir-Blodgett and sequential adsorption. Non-Lithographic

Patterning Methods: microphase separation in copolymers, dewetting processes,

microcontact printing, other uses of self-assembly for pattern creation. 10 Hours

Self Learning Exercise (SLE) – other uses of self-assembly for pattern creation

5. Nanostructure catalytic materials: Nanostructured metals like Pt, Pd and Fe,

nanostructured ceramics like silica, silcate and alumina, pillared clasys, colloids and

porous materials. 6 Hours

Self Learning Exercise (SLE) – colloids and porous materials

6. Meosoporous materias: Introduction, synthesis and characterrization, properties

and application with suitable examples, unipore size, bimodal pore size, graphs,

suprmolecular chemistry and syntehsis (micelar rods), nanoporous materials, synthesis

and application. 10 Hours

Self Learning Exercise (SLE) – synthesis and application

Text Books

1. Handbook of Surface and Interface analysis, J.C.Riviere and S.Myhra, Marcell Decker Inc., 1998 2. Introduction to solid state physics, Charles Kittel, 7th Edition, John Wiley pub, 2000 3. Nanstructured catalsysts- SL Scott, CM crudden and CW Jones

References

1. ASM Handbook, Volume 5, Surface Engineering, ASM International Inc., 1998 2. Basic principles in applied catalysis-Mandfredlaerns 3. Nanotechnology in catalysis- Pinzhan 4. Chemistry of Nanomaterials: synthess, Properties and applications, CNR Rao, A Muller and AK Cheetam.



NANOSENSORS AND DEVICES




_____________________________________________________________


1. Understand the sensing and working mechanism of various sensors.

2. Discuss various physical effects of sensors.

3. Study sensor characteristics and their physical measurands.

4. Explicate sensing behavior with reference to chemicals.

5. Probe and understand various biological sensors.

6. Develop nano based inorganic gas sensors and study its surface modifications effect.

1. Fundamentals of sensors: Micro and nano-sensors, biosensor, packaging and

characterization of sensors, method of packaging at zero level, and first level. Thermal

energy sensors: temperature sensors, heat sensors, electromagnetic sensors, electrical

resistance sensors, electrical current sensors, electrical voltage sensors, electrical

power sensors, magnetic sensors, Mechanical sensors, pressure sensors, gas and

liquid flow sensors, position sensors, chemical sensors, optical and radiation sensors-

gas sensor.

Self Learning Exercises (SLE): Electromagnetic sensors

7 hours

2. Sensor Characteristics and Physical Effects:

Active and Passive sensors – Static characteristic: Accuracy, offset and linearity –

Dynamic characteristic: First and second order sensors, Physical effects involved in

Signal Transduction: Photoelectric effect – Photodielectric effect, Photoluminescence

Effect – electroluminescence effect – chemiluminescence effect, Doppler effect,

Barkhausen effect, Hal effect – nernst / Ettinshausen effect, Thermoelectric effect –

Peizoresistive effect – piezoelectric effect, pyroelectric effect, magneto-mechanical

effect (magnetostriction) – Magnetoresistive effect, Faraday-Henry Law, magneto optic

Kerr effect, Kerrand Pockels Effect.

Self Learning Exercises (SLE): Barkhausen effect

8 Hours

3. Sensor Architecture and Classification:



Medically Significant Measurands, Functional Specifications of Medical Sensors; Sensor

characteristics: linearity, repeatability, hysteresis and drift. Sensor models in the time &

frequency domains. Sensors for physical measurands: strain, force, pressure,

acceleration, flow, volume, temperature and biopotentials.

Self Learning Exercises (SLE): Sensor models in the time & frequency domains

8 Hours

4. Sensors for measurement of chemicals: potentiometric sensors, ion selective

electrodes, ISFETS; Amperometric sensors, Clark Electrode.

Self Learning Exercises (SLE): Amperometric sensors

5 Hours

5. Biological Sensors-1: Sensors/receptors in the human body, basic organization of

nervous system, neural mechanism and circuit processing. Chemoreceptor: hot and

cold receptors, barro receptors, sensors for smell, sound, vision, osmolality and taste..

Non invasive blood-gas monitoring, Blood-glucose sensors.

Self Learning Exercises (SLE): Blood-glucose sensors

6 Hours

6. Nano based Inorganic Sensors

Density of states (DOS) – DOS of 3D, 2D, 1D and 0D materials, one dimensional gas

sensors:- gas sensing with nanostructured thin films, absorption on surfaces, metal

oxide modifications by additives, surface modifications, Nano optical sensors, nano

mechanical sensors, plasmon resonance sensors with nano particles, AMR, Giant and

colossal magnetoresistors, magnetic tunnelling junctions.

Self Learning Exercises (SLE): colossal magnetoresistor

8 Hours

Lab Component: 10 Hours after the sensor lab is set up

Text Books

1. Nanotechnology enabled sensors by Kouroush Kalantar – Zadeh, Benjamin Fry,

Springer Verlag New York, (2007)

2. Biosensing: International Research and Development, Jerome Schultz, Milar

Mrksich, Sangeeta N. Bhatia, David J. Brady, Antionio J. Ricco, David R. Walt, Charles

L. Wilkins, Springer 2006

3. Sensors and signal conditioning, 2nd edition Ramon Pallas-Areny, John G.



Webster John Wiley & Sons (2001).

References:

1 Handbook of Biosensors and Electronic Noses: Medicine, Food and the

Environment: CRC-Press; 1 edition;1996.

2 D. L. Wise, Biosensors: Theory and Applications, CRC Press,1993.

3 Rao & Guha, Principles of Medical Electronics & Biomedical Instrumentation,

Orient Longman.2001.



ENTREPRENEUR DEVELOPMENT & PROJECT MANAGEMENT




______________________________________________________________

Course Outcomes: At the end of this course, students will be able to 1. Explain the general working structure and different issues involved of various industries. 2. Interpret the management aspects and organizational control in industry 3. Understand the concepts of financial decisions and accounts management 4. Describe the basics of research methodology and product life cycle 5. Discuss the marketing srtegies of different goods and services 6. Develop an overview of the impacts nanotechnology and its education by nanoengineers

1. Industry overview: General introduction to Nanotech & Biotech industries. Scope.

Trends and key issues in industry. Organization, financing, policy, trends, problems and

issues in the healthcare, pharmaceutical, Agri and other biotech industries. Overview of

cost, quality, access issues.

Self Learning Exercises (SLE): Overview of Mfg. industries

8 Hours

2. Organization and Management: Management Concepts and Functions.

Development of Management Theories. The Internal and External Environments of the

Organisation. Social Responsibility and Ethics in Management. Managerial Decision

Making. The planning process. The nature of Organization Structure. Organisational

Control. Contemporary issues in Management. Management in Future. Concepts,

structures & functions characterizing contemporary industries in India and other

industrialized nations – model case studies. Management, Need of Managements,

Leadership, Communication Skills for Management; audience awareness, style,

individual and group presentations, conflict resolution. Control of the movement of

goods; coordination of supply and demand and creation and maximization of time and

place utility. Negotiation Strategies.

Self Learning Exercises (SLE): Logistics Systems Management;

8 Hours

3. Financial Resource management



Mobilization of Financial resources; Bank loans & Venture capitalism. Concepts and

techniques of accounting for planning, control, and motivation. Factors influencing

capital acquisition and allocation. Financial decision making; Decision making under

uncertainty; Current issues in financial management.

Self Learning Exercises (SLE): Positive and normative models

6 Hours

4. Industrial R&D &Product Development

Research & development. Product development and project management in Agri,

Pharma, Health and other biotech industries. Overview of issues and techniques

involved in conducting & outcome of research. The multidisciplinary nature of outcomes

research: research design and methods, data collection measurement instruments and

clinical endpoints, quality of life issues, behavior change, and cost-effectiveness.

Analysis Transition from R&D to business units, market learning and transition from

R&D. Management of radical innovation technologies vs. stage gate approach in

product development. Case studies.

Self Learning Exercises (SLE): Product development in Mfg industries

10 Hours

5. Marketing

Introduction to the theory, concepts, skills, and principles of marketing. Business

environment. User-oriented analysis of marketing research process, including problem

definition, design, data collection, data analysis, interpretation, and

presentation. Applications of the theory, concepts, skills, and principles of public

relations in marketing. Development of a marketing management focus, including

market analysis, competitive analysis, and decisions in pricing, product, promotion, and

distribution channels. Study of marketing of goods and services to business, institutions,

and government. Marketing strateg for health, pharmaceutical, and other biotechnology

products.

Self Learning Exercises (SLE): Marketing of services to educational institutions

10 Hours

6. Public Perceptions and Education: Public Interaction Research - Communicating

Nanotechnological Risks - Understanding of Nanotechnology‘s Social Impacts -

Nanotechnology in the Media. Educating Undergraduate Nanoengineers - Interactive,

Entertaining, Virtual Learning Environments – Nanotechnology in Education - Education

Opportunities - Human Resources for Nanotechnology. Management of Innovation for

Convergent Technologies – The "Integration/Penetration Model" - Social Impacts of

Nanobiotechnology Issues - Innovation, Legal Risks, and Society.

Self Learning Exercises (SLE): Analogies for Interdisciplinary Research

10 Hours



NANOTECHNOLOGY AND INDUSTRIAL APPLICATIONS




Course outcomes


1. Introduce the nano and biotech and Agricultural industries, their major key

issues, trends and problems, discussing the financing, cost and quality issues.

2. Explain the nanoparticles and micro-organism and their application in food and

cosmetic, textile industry, paints, waste water treatment etc.

3. Discuss the industry R&D and developing project management, product

development and market learning skills.

4. Define the physical and chemical properties of molecular crystals, organic

electroluminescent display, examples of nanotechnology based products in market.

5. Explain the electronic structure and fabrication techniques for semiconductor

nanostructure and their application towards industry.

6. Introduce the nanotechnology revolution, social-economic impact of nanoscience,

semiconductor scaling as a model for nano-technology commercialization.

1. Industry overview

General introduction to Nanotech & Biotech industries. Scope, Trends and key issues in

industry. Organization, financing, policy, trends, problems and issues in the healthcare,

pharmaceutical, Agri and other biotech industries. Overview of cost, quality, access

issues. 6 Hours

Self Learning Exercise (SLE) – Overview of cost, quality, access issues

2. Nanoparticles in industry: Nanoparticles and microorganism, nanomaterials in

bone substitutes and dentistry, Food and cosmetic applications, textile industry, paints,

catalysis industry, nanoparticles in waste water treatment, photocatalysis, filters and

candles, disinfection and antimicrobial filters. 8 Hours

Self Learning Exercise (SLE) – Disinfection and antimicrobial filters

3. Industrial R&D and Product Development

Industrial R&D and product development. Product development and project

management in health and other biotech industries. Analysis Transition from R&D to

business units, Overview of issues and techniques involved in conducting & outcome of

research. Product development, market learning, Case studies.

8 hours

Self Learning Exercise (SLE) – Analysis Transition from R&D to business units



4. Molecular electronics: Hybridization, conjugation, excitations, molecular crystals,

conducting vs. semiconducting polymers, organic electroluminescent displays infection,

transport, exciton formation, light emission phosphors, influence of supramolecular

order, excimers, liquid crystal display. Nanotechnology products in markets, examples.

1 10 Hours

Self Learning Exercise (SLE) – Organic electroluminescent displays

5. Metal and Semiconductor Nanostructures: Introduction, electronic structure and

properties, Synthesis and Fabrication techniques, Principles and performance of

semiconductor nanostructure based electronic and electro-optical devices. Magnetic

nanostructures: Magnetism in solids, properties of nano magnetic materials,

Nanostructure relationships, fabrication and properties of nanostructure magnets,

electronic magneto transport, applications in automobile and data storage industry.

10 Hours

Self Learning Exercise (SLE) – Principles and performance of semiconductor

nanostructure based electronic and electro-optical devices

6. Socio-Economic Impact of Nanoscale Science: Managing the Nanotechnology

Revolution, Consider the Malcolm - Transcending Moore‘s Law with Molecular

Electronics and Nanotechnology - Semiconductor Scaling as a Model for

Nanotechnology Commercialization - Nanotechnology and Zettabits - Sustaining the

Impact of Nanotechnology - Non-Nano Effects of Nanotechnology on the Economy.

10 Hours

Self Learning Exercise (SLE) – Malcolm - Transcending Moore‘s Law with

Nanotechnology

Text Books

1. Innovation and Incentives, Suzanne Scotchmer, MIT Press 2004.

2. Industrial Organization: Contemporary Theory & Practice, 3e.

3. Mihail C. Roco and William Sims Bainbridge, ―Nanotechnology: Societal Implications

II – Individual Perspectives―, Springer Publishers, Sponsored by National Science

Foundation, ISBN-10 1-4020-4658-

References:

1. C.W.Turner, T.VanDuzer, Principles of superconductive devices and circuits, 1981

2. Reynolds, M Pomeranty, Electroresponsive molecules and polymeric systems,

Skotheim T. Marcel Dekker, New York, 1991.

3. A.Yariv, Principles of optical electronics, John Wiley, New York, 1984.

4. D.D.C.Bradley, Current opinion in solid state and Materials science vol 1 789 (1996).



NANOTECHNOLOGY AND DRUG DELIVERY SYSTEMS

Sub Code : 12MNT0407 CIE : 50% Marks




1. Knowledge on selectivity and sensitivity of drug delivery and targeting.

2. Select and apply appropriate nanoparticles as drugs and their functionalization.

3. Learn Nanoparticles as drugs to appropriate sites with controlled release of drugs.

4. Give an example and explain the function and potential application of DNA based

structures.

5. How nano-assisted technologies compare to conventional medical devices.

6. Descriptive view of how nanotechnology appreciates drug discovery, delivery and its

application.

1. Principles of drug delivery systems: modes of drug delivery, ADME hypothesis – controlled drug delivery, site specific drugs , barriers for drug targeting, passive and active targeting, Strategies for site specific, time and rate controlled delivery of drugs, antibody based and metabolism-based targeting.

Self Learning Exercises (SLE): passive and active targeting

8 Hours

2. Nanoparticles as Drugs: Structure and Preparation, Liposomes, Cubosomes and

Hexosomes, Lipid based Nanoparticles-Liquid nanodispersions- Solid Lipid

Nanoparticles (SLP), Biofunctionalsiation of SLP, Charatcterisation- Nanoparticles for

crossing biological membranes. Fundamentals- Physicochemical Principles of

Nanosized Drug Delivery Systems-Nanotubes, Nanorods, Nanofibers, and Fullerenes

for Nanoscale Drug Delivery, Carbon nanotubes biocompatibility and drug delivery.

Self Learning Exercises (SLE): Fullerenes for Nanoscale Drug Delivery

9 Hours

3. Targetted Nanoparticles for drug delivery: Nanoparticles surface modification,

bioconjugation, pegylation, antibodies, cell-specific targeting and controlled drug

release, Multi-Functional Gold Nanoparticles for Drug Delivery: Virus Based-

nanoparticles.



Dendrimers as Nanoparticular Drug Carriers: Synthesis – Nanoscale containers ––

Naoscafold systems – Gene transfection, Biocompatibility Polymer Micelles as Drug

Carriers, Polymers nanotubes- Magnetic Nanoparticles as Drug Carriers.

Self Learning Exercises (SLE): Virus Based-nanoparticles

12 Hours

4. Liposomes for drug delivery and targeting: classification and preparation of

liposomal nanoparticles. Liposomes for pharmaceutical and cosmetic applications,

Liposomal Drug Carriers in Cancer Therapy, lipid-DNA complexes, viral gene

transfection systems, Lipid based drug delivery systems for peptide and protein drug

delivery, Liposomal anticancer and antifungal agents.

Self Learning Exercises (SLE): Liposomal Drug Carriers in Cancer Therapy

9 Hours

5. Nanoparticle and targeted systems for cancer diagnosis and therapy: Targeted

delivery through enhanced permeability and retention. Folate receptors, Targeting

through angiogenesis, Targeting to specific organs or tumor types, Tumor-specific

targeting: Breast cancer, Liver, Targeting tumor vasculature for Imaging, Delivery of

specific anticancer agents: such as Paclitaxel, Doxorubicin,5-Fluorouracil etc.

Self Learning Exercises (SLE): Targeting through angiogenesis

7 Hours

6. Drug Discovery & Delivery: Drug Discovery Using Nanocrystals, Drug Discovery

Using Resonance Light Scattering (RLS) Technology. Benefits of Nano-Imaging Agents,

Nanosensors in Drug Discovery, Drug Delivery using Nanobiosensors, Drug Delivery

Applications, Bioavailability, Suistained and targeted release, Nanorobots, Benefits of

Nano-Drug Delivery. Drug Delivery, Health Risks, and Challenges, Targeting. Drug

Delivery Revenues. Use of microneedles and nanoparticles for local highly controlled

drug delivery.

Self Learning Exercises (SLE): Drug Delivery Revenues

7 Hours

Text Books

1. Drug Delivery: Engineering Principles for Drug Therapy, M. Salzman,

2. Drug Delivery: Principles and Applications, B. Wang, Wiley Intersceince, 2005.

3. NANOTHERAPEUTICS: Drug Delivery Concepts in Nanoscience edited by Alf

Lamprecht

Reference



1. Nanoparticulate Drug Delivery Systems Deepak Thassu, Michel Deleers (Editor),

Yashwant Pathak

2. Drug Delivery and Targetting, A.M.Hillery, CRC Press, 2002.

3. Bio-Applications of Nanoparticles Warren C.W. Chan

4. Lisa Brannon-Peppas, James O. Blanchette Nanoparticle and targeted systems for

cancer therapy Advanced Drug Delivery Reviews 56 (2004) 1649– 1659

RAPID PROTOTYPING (4-0-0)


Hrs / Week : 04 SEE : 50% Marks

SEE Hrs : 52 Hrs Max. Marks : 100

______________________________________________________________________

Course Outcomes


1. Explain the importance and growth of Rapid Prototyping Techniques. 2. Differentiate and describe the operation, applications and advantages of Stereo lithography, selective Laser sintering and fused deposition modeling. 3. Analyze solid ground curing and laminated object manufacturing processes and their working. 4. Able to evaluate different Concept Modelers. 5. Recommend different tooling requirements for Rapid Prototyping. 6. Able to optimize rapid prototyping process.

1.Introduction: Need for the compression in product development, Growth of RP

industry, and classification of RP systems.

Self learning component: History of RP systems, Survey of applications

9 Hrs

2. Stereo Lithography Systems: Principle, Process parameter, Process details, Data

preparation Application,

Selective Laser Sintering and Fusion Deposition Modeling: Type of machine,

Principle of operation, process parameters, Data preparation for SLS, Applications,

Principle of Fusion deposition modeling, Process parameter, Path generation,

Applications.

Self learning component: data files and machine details,

9 Hrs

3. Solid Ground Curing: Principle of operation



Laminated Object Manufacturing: Principle of operation, LOM materials, Process

details, Machine details

Self learning component: Applications of LOM and SGC.

9Hrs

4. Concepts Modelers: Principle, Thermal jet printer, Sander's model market, 3-D

printer. Genisys Xs printer HP system 5

Self learning component: Object Quadra systems.

8Hrs

5. Rapid Tooling: Indirect Rapid tooling -Silicone rubber tooling –Aluminum filled epoxy

tooling Spray metal tooling, , 3Q keltool, etc >Direct Rapid Tooling Direct. AIM, Quick

cast process, Copper polyamide, DMILS, Prometal, Sand casting tooling, Laminate

tooling soft Tooling vs. hard tooling.

Self learning component: Cast kirksite and Rapid Tool

9Hrs

6. RP Process Optimization: factors influencing accuracy. Data preparation errors,

Part building errors, Error in finishing,

Self learning component: Selection of part build orientation.

9Hrs

TEXT BOOKS:

1. Pham D.T. & Dimov S.S "Rapid Manufacturing" Springer London 2011.

REFERENCE BOOKS:

1. Terry Wohlers "Wohler's Report 2000" Wohler's Association 2000.

2. Paul F. Jacobs: "Stereo lithography and other RP & M Technologies", SME, NY

1996,Springer

NANOBIOTECHNILOGY




Course Outcomes


1. Understand the basics of Biotechnology

2. Explain the interaction between biomolecules and nanoparticle surface and its

applicaitons.

3. Optimise the synthesis of Biocompatibility of Nanomaterials



4. Analyze different types of DNA based Nanostructures

5. Evaluate Implications in Neuro science, tissue engineering and medical applications.

6. Identify the risk assessments involved bio nano materials

Unit-1 Fundamentals of Biotechnology: Basic terms in biotechnology, Biological

building blocks; Sizes of building blocks and comparison with nanostructures.

Introduction to Proteins, lipids, DNA, Membrane structures. PHA, cyanophcin inclusion,

magnetosome, alginates, bacteriophages, bacteriospores,

Self Learning Exercises (SLE): bacterial protein complex, S-layer protein,

bacteriorhodpsin.

6 Hours

Unit-2 Interaction between biomolecules and nanoparticle surface: Different types

of inorganic materials used for the synthesis of hybrid nano-bio assemblies, Application

of nano in biology, nanoprobes for Analytical Applications - A new methodology in

medical diagnostics and Biotechnology,

Self Learning Exercises (SLE): Current status of Nanobiotechnology, Future

perspectives of Nanobiology.

08 Hours

Unit-3 Biological synthesis of Nanomaterials: synthesis using microorganisms,

synthesis using plant extracts, synthesis using proteins and DNA templates. Nanoscale

magnetic iron minerals in bacteria, virus & fungi. DNA based Nano structures. Protein

based Nano structures. Introduction-Biocompatibility – anti bacterial activity – principles

involved – Applications. Biomaterial nanocircuitry; Protein based nanocircuitry; Neurons

for network formation. DNA nanostructures for mechanics and computing and DNA

based computation; DNA based nanomechanical devices. Function and application of

DNA based nanostructures. In-vitro laboratory tests on the interaction of nanoparticles

with cells.

Self Learning Exercises (SLE): Biomechanical strength properties of Spider silk.

10 Hours

Unit-4 DNA based nanostructures; DNA, structure of DNA, genetic code and protein

synthesis. Topographic and Electrostatic properties of DNA and proteins – Hybrid

conjugates of gold nanoparticles – DNA oligomers – Use of DNA molecules in

nanomechanics and Computing. DNA-protein nanostructures-Methods- Self assembled

DNA nanotubes—Nucleic acid Nanoparticles, DNA as a Biomolecular template-DNA

branching-Metallization- Properties. DNA Origami. Photoinduced Electron Transport in

DNA: Toward Electronic Devices Based on DNA Architecture- DNA Nanowires- Charge

Transport- DNA-Based Nanoelectronics- Electrical Manipulation of DNA on Metal

Surfaces,

Self Learning Exercises (SLE): Nanostructured Biocompartments- DNA-Gold

nanoconjugates.



10 Hours

Unit-5 Nanomaterials in medical application: Nanomaterials in bone substitutes &

Dentistry, Drug delivery and its applications, Biochips- analytical devices, Biosensors-

Natural nanocomposite systems as spider silk, bones, shells; organic-inorganic

nanocomposite formation through self-assembly. Polymeric nanofibres – Implications in

Neuro science, tissue engineering and cancer therapy. Poly electrolyte multilayers-

coated colloids- smart capsules. Colloids and colloids assembly of bio nanotechnology.

Self Learning Exercises (SLE): Micro emulsions in nanotechnology.

10 Hours

Unit-6 Risk assessment and Nanomaterials: Effects of steric hindrance, inflammatory

and immune based mechanisms – critical variables – exposure and effects through

ingestion – diffusion – endocytosis – exposure and effects through dermal absorption –

exposure and effects through inhalation – mechanism for adsorption and removal –

pulmonary toxicology – known toxicity of nanomaterials. Assessment of the toxic effects

of nanoparticles based on in-vitro laboratory tests.

Self Learning Exercises (SLE): Identification of pathogenic organisms by magnetic

nanoparticle-based techniques.

08 Hours

TEXT BOOKS

1. Nanobiotechnology by Christof M Niemeyer, Chad A Mirkin, Wiley VCH, 2006

2. Jain K.K, Nanobiotechnology in Molecular Diagnostics – Current Techniques and

Applications. Taylor and Francis Publications 2006.

3. Bio-Applications of Nanoparticles BY Warren C.W. Chan, Springer Science+Business

Media, 2007

REFERENCE BOOKS

1. Nanotechnology in Drug Delivery by Melgardt M.deVilliers, Pornanong Aramwit, Glen

S.Kwon, Springer-American Association of Pharmaceutical Scientists Press 2009.

2. Bionanotechnology - Global Prospects by David E. Reisner, Taylor & Francis Group,

LLC, 2009.

3. Applications of nanoparticles in biology and medicine by Salata O.V. Journal of

Nanobiotechnology, 2:3, 2004.

http://www.infibeam.com/Books/springer-sciencebusiness-media-publisher/

http://www.infibeam.com/Books/springer-sciencebusiness-media-publisher/



NANOTECHNOLGY IN FOOD AND AGRICULTURE




______________________________________________________________________

Course outcomes


1. Define intermolecular as well as hydrophilic and hydrophobic interactions, soluble

polymers, self assembly in plant cells.

2. Introduce the nanotechnology in food, food production, antimicrobial functionality,

functional materials in food nanotechnology.

3. Explain the nanotechnology in Agricultural field, different Enzyme and DNA

based biosensors, RFIDs tag, Nano-sensors networks.

4. Define advanced processing techniques for food processing like infrared

processing, dielectric heating, microwave processing, and self-life analysis of food

characteristics.

5. Elucidate food quality, safety and security of agricultural product, packaging and

distribution, nanomaterials for food applications.

6. Explain the technology issues, life cycle of nanotechnology food product, food

allergy, impact of nanoscale structures on food product.

1. Intermolecular Interactions Introduction, Hydrophobic and Hydrophilic Interactions,

Dispersion Interaction, Electrostatic Interactions, Steric Interactions Involving Soluble

Polymers. Self-Assembly, Plant Cells, Organized Self-Assembled Structures.

8 Hours

Self Learning Exercise (SLE) – Organized Self-Assembled Structures

2. Nanotechnology in Food: Introduction, Food Production, Antimicrobial

Functionality, Visual Indicators, Physics and Structures in Food Bionanotechnology,

Information and Communication Technology, Fibrillar Structures, Plate-Like Structures,

Spherically Symmetric Structures, Bi-continuous Structures in Protein–Polysaccharide

Systems, Gastronomy and the Nanodomain: Molecular Gastronomy, functional

materials in food nanotechnology. 10 Hours

Self Learning Exercise (SLE) – Structures in Protein–Polysaccharide Systems

3. Nanotechnology in Agricultural: Introduction, Biosensors, Enzyme Biosensors and

Diagnostics, DNA-Based Biosensors and Diagnostics, Radiofrequency Identification



(RFID), Integrated Nanosensor Networks: Detection and Response, Precision

Agriculture, Potential Changes in Farming Methods and Sustainable Agriculture.

10 Hours

Self Learning Exercise (SLE) – Precision Agriculture

4. Advanced Processing Technologies: Introduction, Preservation Methods, Drying

Techniques, Conventional methods and its limitation, Infrared processing, di-electric

heating, microwave processing, batch type and conveyor type systems, shelf-life,

analysis of food characteristics. 8 Hours

Self Learning Exercise (SLE) – shelf-life, analysis of food characteristics

5. Food Quality, Safety, and Security: Introduction, Improving Quality, Safety, and

Security of Agricultural Production, Food Processing, Packaging and Distribution.

Concerns about using Nanotechnology in Food Production. Reasons to Package Food

Products, Physical Properties of Packaging Materials. Safety Assessment of Oral-

Exposure Engineered Nanomaterials for Food Application. Toxicity aspects of

nanofood, modification of nano materials to avoid toxic effect and commercial aspect.

10 Hours

Self Learning Exercise (SLE) – Toxicity aspects of nanofood

6. Technology Issues: Life Cycle of Nanotechnology Food Products, Molecules in

Foods Involved in Triggering Allergies, Processing, and Food Allergy, Impact of

Nanoscale Structures on Allergenic Potential of Foods, Innovations in Food and

Agriculture Nanotechnology. 6 Hours

Self Learning Exercise (SLE) – Molecules in Foods Involved in Triggering Allergies

Text Books

1. Lynn J. Frewer, Willem Norde, Arnout Fischer, Frans Kampers ―Nanotechnology

in the Agri-Food

Sector‖ John Wiley and Sons,2010

2. S.Choudhary, ‗Applied Nanotechnology in Agriculture‘, Arise Publication, 2011.

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