4. Schematic Diagram

Increased Estrogen and Progesterone levels in the Body

Abnormal growth factors are releasedIn the system Decreased cytokine production

Stimulation of uterine cell tissue

Increased uterine cell mitotic rate

Monoclonal proliferation of neoplastic uterine smooth muscle cells

Predisposing Factors

Sex – Female

Reproductive Age

Genetic Predisposition

Nulliparous

Early menarche

Precipitating Factors

Use of fertility pills

Smoking

Intake of fatty foods

Continuous growth of neoplasm with absence of tumor suppressor cells

Inhibition of apoptosis of neoplastic cells

Proliferated cells eventually form tissues

Development of uterine fibroid (leiyomyomas) withinin the myometrium

Adequate vascular supply of O2 and nutrients

Increase in size of uterine myoma

Endometrial enlargement and distention

Impaired uterine lining Blockage of

fallopian tubeDistorted uterine

shapeImpaired uterine

function

Intramural Myoma

Primary Infertility

Palpable Abdominal Mass

MenorrhagiaConstipationUrinary FrequencyDifficult DefecationAbdominal PainAbdominal DistensionAbdominal Tenderness