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Page 1: SBCC overview.pptx [Read-Only]slides).pdf · SAS, SPSS and their many descendants. ... (sampling weights) Proteomics / metabolomics (PLS, OPLS‐DA) ... SBCC overview.pptx [Read-Only]

SBCC

Statistical / BiomathematicalConsulting Clinic

Biomathematics DepartmentDavid Geffen School of Medicine at UCLA

5202 Life Sciences Bldg310‐825‐4193

Look within Biomath dept website:www.biomath.ucla.edu/about/consulting

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History

Originally founded in 1962 by Wilfred Dixon as the Health Sciences Consulting Clinic, the S.B.C.C. has not only been serving the biomedical community as part of the UCLA Biomathematics department but also was the birthplace of the BMDP software, one of the first statistical “packages” and a grandfather to SAS, SPSS and their many descendants. 

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Will Dixon‐ Founder

IBM Terminals ‐ Dr. Wilfrid Dixon, Dr. Sherman Mellinkoff and Dr. Foster Sherwood of UCLA next to an IBM 1410 data processing systems

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SBCC was the birthplace of BMDP

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SBCC Clinic model

Like a medical clinic, we are your “primary care” statisticians.  We cover most “routine” statistical planning and analysis issues. We also try to make a “referral” to the faculty or other specialized experts when we encounter problems that require narrow, advanced expertise. 

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Services providedStatistical analyses & reports (to PI) Clinical Trials preparationStudy design protocol developmentStatistical analysis plans & sample size/power calculationsAssistance with methodology section for grantsDesign and  implementation of databasesModelling (with Biomathematics faculty)Workshops in statistics/methodsReport preparationManuscript and paper reviews

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Areas of expertiseGeneralized linear models:(linear, logistic, Poisson, Cox regression, ANOVA)ROC‐ Sensitivity, specificity, accuracyRepeated measure analysesSurvival & competing risks (including trees) Structural equations – path analysesClassification trees & random forests (supervised learning) Cluster analysis (unsupervised learning)Survey sampling (sampling weights) Proteomics / metabolomics (PLS, OPLS‐DA) (with Yingnian Wu, Yi Yi, Jan DeLeeuw, Kym Faull)

Sample size / power calculationsPharmacokinetics (with Elliot Landaw)

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SoftwareSAS – General purposeJMP – General purpose – menu drivenSTATA –General purposeR – General purpose.    XCMS – mass spec in R SPSS‐ General purposeAnswer Tree ‐ CARTPASS ‐sample sizeAMOS ‐structural equationsTutorials available for JMP (SAS, STATA, SPSS covered by IDRE) 

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A full collaborationInitial meeting ‐ free! (up to a point)

Statistical Analysis Plan (& sample size)Data management plan

(Study execution ‐ Data collection) Interim analyses

Final Analyses & ReportsResponses to reviewers

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Checklist for investigatorsPreparation for the S.B.C.C. meeting

•Study questions / aims ‐ prioritized•Study design:Experiment (trial), observational

•Target population: cells, animals, humans, …•Outcome measures/endpoints:

Primary, secondary, … •Comparison groups•Potential confounding factors/covariates 

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SBCC Motto

Our motto “ the earlier the better”

NOT our motto “never enough time to do it right and always enough time to do it over”

Contact:  Jeff Gornbein    310‐825‐[email protected] to request services

Martha Riemer (manager)  310‐206‐[email protected] to establish a billingaccount for requested services

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When doing research, one should try to follow the advice of Mark Twain.

“Always tell the truth.This will gratify some peopleand astonish the rest”. 

We can help you get closer to the truth.