saturnnewsletter 2 2014 - krisp · johanna ledwabab, sam pickerillc, martina penazzatod, silvia...
TRANSCRIPT
Introduc)on:
The concept behind this newsle0er is that anyone with 15 minutes to spare can learn about the work of SATuRN
The newsle0er is presented as a PDF document with links to complete arAcles at bioafrica.net. In our second issue of 2014, we would like to bring a0enAon to our annual workshop that will be presented as part of the 2014 Annual Workshop on Advanced Clinical Care -‐ AIDS (AWACC), Durban, 8-‐9 Oct 2014.
We have also included interesAng news, blogs, reports, tweets, publicaAons and training informaAon produced by our network
Produced by: Tulio de Oliveira, Tobias Rinke de Wit, Anna Salimo, Henry Sunpath, Yunus Moosa, Siva Danaviah, Justen Manasa, Gillian Hunt, Adriaan E. Basson, Lynn Morris, Jose Ijedema & Chris Seebregts
Highlights:
Workshop: Annual Workshop on Advanced Clinical Care (AWACC), Durban, 9-‐10 October 2014.
Mee)ng: Policy Mee)ng on HIV drug resistance, Lusaka, Zambia, 6 May 2014.
Inaugural lecture: Prof. Tulio de Oliveira, Nelson Mandela School of Medicine, UKZN, Durban, 30 Jul 2014.
Publica)on: Circula)ng Biomarkers of Immune Ac)va)on Dis)nguish Viral Suppression from Nonsuppression in HAART-‐Treated Pa)ents with Advanced HIV-‐1 Subtype C Infec)on.
Publica)on: Drug resistance among newly diagnosed HIV-‐infected children in the era of more efficacious an)retroviral prophylaxis.
Blog/Publica)on: High-‐Level Cross-‐Resistance to Didanosine in Children Failing 1st-‐Line Regimen.
SATuRN: Newsle0er Southern Africa Treatment and Resistance Network
Vol 3, Num 2 Mar-‐ Jul 2014
Policy Mee)ng on HIV drug resistance, Lusaka, Zambia. PASER -‐ 2014-‐03-‐19
“To discuss rising levels of drug-‐resistant HIV and potenAal responses to this concern, the Amsterdam InsAtute for Global Health and Development (AIGHD) and the Pan-‐African Studies to Evaluate Resistance (PASER) network convened a closed policy meeAng in Lusaka, Zambia on 6 May 2014. ”
Link: h0p://www.bioafrica.net/blogs.php?id=33
Inaugural Lecture: Bioinforma)cs, Genomics and HIV Research in Africa: A Brief Personal History UKZN -‐ 2014-‐07-‐30
“The Vice-‐Chancellor and Principal Professor Malegapuru Makgoba cordially invites you and your spouse/partner to a0end an inaugural lecture presented by Professor Tulio de Oliveira, K-‐RITH, Nelson R Mandela School of Medicine, Durban, 30 July 2014”
Link: h0p://www.bioafrica.net/news.php?id=118
Blog: The fidelity of HIV-‐1 RT is not as bad as we thought Adriaan E. Basson -‐ 2014-‐07-‐24
“In a recent publicaAon, the replicaAon fidelity of HIV-‐1 reverse transcriptase (RT) was invesAgated under physiological condiAons. It is well known that HIV-‐1 RT is error prone. The authors indicate that the low fidelity of HIV-‐1 RT is on par with that of most other RT enzymes, under physiological condiAons”
Link: h0p://www.bioafrica.net/blogs.php?id=34
Seminar: Genome-‐wide associa)on study indicates two novel resistance loci for severe malaria Andreas Ziegler – 2014-‐08-‐01
“The The Wellcome Trust Africa Centre Genomics & Pop. Epidemiology Programmes, UKZN MRC Flagship project & UKZN School of MathemaAcs, StaAsAcs and Computer Science cordially invites you to a seminar presented by Prof. Andreas Ziegler, 1 August 2014, Council Chambers, Westville Campus, UKZN, Durban“
Link: h0p://www.bioafrica.net/news.php?id=119
Blog: NICD accredited by WHO for HIVDR tes)ng using DBS specimens Anna Salimo -‐ 2014-‐01-‐15
“The NICD laboratory in Johannesburg has been performing HIV-‐1 drug resistance (HIVDR) tesAng for surveillance purposes using plasma or serum specimens. The World Health OrganizaAon (WHO) have adjusted their requirements for accreditaAon to include HIVDR tesAng on dried blood spots (DBS) due to their ease of collecAon, handling, transportaAon and storage”
Link: h0p://www.bioafrica.net/news.php?id=120
Brief: News & Blogs on our work and collaborators
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SATuRN Newsle0er, vol 3, number 2, July 2014
Postdoc Fellowship available -‐ HIV Genomics & Bioinforma)cs I. This Fellowship aims to apply and develop bioinforma)cs sofware applica)ons to analyze large datasets of complete HIV-‐1 genomes.
Link: h0p://www.bioafrica.net/news.php?id=125
HIV Bioinforma)cs & Phylogene)cs II. This Fellowship aims to develop and/or apply sofware applica)ons to create a framework to iden)fy epidemiologically and drug resistance important HIV strains
Link: h0p://www.bioafrica.net/news.php?id=124
HIV & HTLV Bioinforma)cs & Phylogene)cs III. This fellowship aims to apply and develop bioinforma)cs sofware applica)ons to analyze large datasets of HIV-‐1 and HTLV-‐1 complete genomes
Link: h0p://www.bioafrica.net/news.php?id=123
Postdoctoral Research Fellows in HIV -‐ We invite applica)ons for 6 postdoctoral posi)ons to be based in the Africa Centre for Health and Popula)on Studies in collabora)on with UCL, LSHTM and FioCruz.
Link: h0p://www.bioafrica.net/news.php?id=115
Fellowships: Six HIV research fellowships available!
We invite applicaAons from ambiAous clinical or non-‐clinical postdoctoral scienAsts, to undertake research in HIV drug resistance, pathogenesis, bioinformaAcs, genomics, epidemiology and health systems at a Flagship programme of the Wellcome Trust & MRC in South Africa
Link: h0p://www.bioafrica.net/news.php
More informa)on:
SATuRN Newsle0er, vol 3, number 2, July 2014
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Dates: 8 and 9 October 2014
Applica)on deadline: 8 and 9 October 2014
Website: www.awacc.org
Registra)on & Info: [email protected]
SATuRN Newsle0er, vol 3, number 2, July 2014
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SATuRN Newsle0er, vol 3, number 1, March 2014
AWACC preliminary program, Durban, 8-‐9 Oct 2014
THURSDAY CHAIR: SUNPATH H FRIDAY CHAIR: CHELIN N
8-1030 S.BROWN Þ Management Of HIV Associated
Arthropathy A.B. Maharaj (DOH) Approach To Cytopaenias In HIV (M.Bizarre -DOH) Þ An Approach To HIV And Renal Failure In An Environment With Restricted Renal Replacement (N.Madala) DVT –Case Series Ebrahim Varaiva (WITS
8-1030 L.GURUVADU Þ) Metabolic Complications Of ART
D. Spencer (RTC) Point of care testing for PLHIV and coinfections-Paul Drain(Harvard) Þ PEP /PREP F.Venter (Wits) When To Start ART In Different Contexts Deenan Pillay (Africa Centre & UCL)
11-1300 M.GORDON SATuRN SESSION
Þ Developing New Strategies For ART Regimens -Mark Wainberg (Mc Gill Montreal) Þ Understanding Resistance Mutations When Choosing Second And Third Line ART -Carole Wallis Þ Adult Resistance Case Studies .Cloete van Vuuren (UFS)
11-1300 T DE OLIVEIRA & Y.MOOSA
SATuRN SESSION:
Þ Are Drug Resistant Viruses Less Fit? Pro and Con debate with Case discussion Theresa Roussouw Deenan Pllay F.Venter SATURN panel
14-1600 K.GATES Session 1 (SATuRN)
Þ **Early Warning Indicators For Virological Failure In The African Context .V. Marconi (Emory) Þ **Tools To Measure Adherence Catherine Orell (UCT) Þ HIV Elite Controllers (Thumbi Ndungu)
14-1600 MatCH Decentralised Management Of
MDR-TB l (Master) Þ TB IRIS- Still A Challenge MYS Moosa (UKZN) Þ Managing LFT Abnormality In TB HIV T.Manzini (UKZN) Þ Managing Drug Interactions Between Rifamycin Aad Four Classes Of ARVs and Co-treatment Of TB And HIV Infection In Children And Pregnant Women F.Conradie . (WITS)
14-1600
T.IBRAHIM Session 2 Þ Preventing HIV Related Maternal Mortality (DOH) Þ Practical Approach To Fertility In HIV (DOH) Þ PMTCT –New Guidelines (UKZN)
14-1600 Z.BANOO Session 2
Þ ART Initiation In Infants– The New Challenge Niel Mc Kerrow (DOH) Managing The Adolescent Living With HIV . Brian Zanoni (Harvard) Management of treatment failure in children –M.Archary (UKZN)
16.30 -18.30 N.MAGULA -Chemotherapy for common
infections among PLHIV-Melanie John (UKZN) Þ **Pain And Symptom Management In People Living With HIV –Liz Gwyther (HPCA) Þ Approach To Surgical Management In PLHIV (UKZN)
1630-1830 MAWELA Þ Primary Health Care
Re-engineering: A new Paradigm In Health Care. H.Sunpath (UKZN) Þ **The Good And Bad News About Increase Incidence In Newly Diagnosed HIV Q.A. Karim (CAPRISA) Closing session
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CE: Namrta; AIDS-D-14-00013; Total nos of Pages: 6;
AIDS-D-14-00013
CONCISE COMMUNICATION
Drug resistance among newly diagnosed HIV-infectedchildren in the era of more efficacious
antiretroviral prophylaxis
Louise Kuhna, Gillian Huntb, Karl-Gunter Technauc, Ashraf Coovadiac,
Johanna Ledwabab, Sam Pickerillc, Martina Penazzatod,
Silvia Bertagnolioe, Claude A. Mellinsf, Vivian Blackg,
Lynn Morrisb and Elaine J. Abramsh
Background: In the era of more efficacious prevention of mother-to-child transmission(PMTCT) regimens, documenting the profile of drug resistance in HIV-infected infantsand young children is critical to our efforts to improve care and treatment for children.
Methods: HIV drug resistance mutations in plasma virus were ascertained usingpopulation sequencing among 230 newly diagnosed HIV-infected children under2 years of age recruited in Johannesburg, South Africa, during 2011. By this time,more effective PMTCT regimens, including combination antiretroviral therapy forpregnant women, were being implemented.
Results: Two-thirds (67.4%) of HIV-infected children had been exposed to someform of maternal (89%) and/or infant (97%) PMTCT. Among PMTCT-exposed,56.8% had nonnucleoside reverse transcriptase inhibitor (NNRTI), 14.8% nucleosidereverse transcriptase inhibitor (NRTI), and 1.3% protease inhibitor mutations. NNRTImutations were strongly related to younger age. The remaining third (32.6%) hadno reported or recorded PMTCT exposures, but resistance to NNRTI was detected in24.0%, NRTI in 10.7%, and protease inhibitor in 1.3%.
Conclusion: The new PMTCT strategies dramatically reduce the number of childrenwho acquire infection, but among those who do become infected, NNRTI resistanceprevalence is high. In this South African setting with high PMTCT coverage, almosta quarter of children with no reported or recorded PMTCT also have drug resistancemutations. PMTCT history is an inadequate means of ruling out pretreatment drug
aGertrude H. Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of PublicHealth, Columbia University, New York, New York, USA, bNational Institute for Communicable Diseases of the National HealthLaboratory Services, cFaculty of Health Sciences, Empilweni Services and Research Unit, Department of Paediatrics & ChildHealth, Rahima Moosa Mother and Child Hospital, University of the Witwatersrand, Johannesburg, South Africa, dMRC ClinicalTrial Unit, University College London, London, UK, eHIV Department, World Health Organization, Geneva, Switzerland, fHIVCenter for Clinical and Behavioral Studies in the Division of Gender Sexuality and Health, Department of Psychiatry, ColumbiaUniversity and the New York State Psychiatric Institute, New York, New York, USA, gFaculty of Health Sciences, WitsReproductive Health and HIV Institute, University of Witwatersrand, Johannesburg, South Africa, and hICAP, Mailman School ofPublic Health, and Department of Pediatrics, College of Physicians & Surgeons, Columbia University, New York, New York, USA.Correspondence to Louise Kuhn, PhD, Gertrude H. Sergievsky Center, Columbia University, 630 W 168th Street, New York, NY10032, USA.E-mail: [email protected]: 2 January 2014; revised: 12 February 2014; accepted: 12 February 2014.
DOI:10.1097/QAD.0000000000000261
ISSN 0269-9370 Q 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins 1
SATuRN Newsle0er, vol 3, number 2, July 2014
Twiier: SATuRN has a very ac)ve YouTube Channel and Twiier
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SATuRN YouTube channel:
In these new secAons of the bioafrica.net and YouTube websites, we disseminate videos of our work and its applicaAon in everyday life
Links:
h0p://www.youtube.com/bioafricaSATURN
h0p://www.bioafrica.net/videos.php
SATuRN Twiier Account:
SATuRN has a very acAve twi0er account. In addiAon, collaborators have tweeted at HIV & TB drug resistance events and conferences around the globe…
Links:
h0p://www.twi0er.com/drug_resistance
h0p://www.bioafrica.net/
SATuRN Newsle0er, vol 3, number 1, March 2014
SATuRN twiier @drug_resistance
Please follow us!
For more informa)on on how to par)cipate in SATuRN ac)vi)es please contact:
Prof Tulio de Oliveira, Wellcome Trust Africa Centre for Health and Popula)on Studies, UKZN, South Africa Tel : +27 35 550 7500, Fax: +27 35 550 7565, e-‐mail : tdeoliveira@africacentreacza
Prof Chris Seebregts, Jembi Health Systems, South Africa Tel: +27 21 701 0939, Fax: +27 21 701 1979, e-‐mail: chris@jembiorg
Disclaimer: The SATuRN consorAum wishes to express its graAtude to the following funders for their generous support for the producAon of this report: European Commission (EC), Centers for Disease Control and PrevenAon (CDC funding for SoPH/UWC and CAPRISA), President's Emergency Plan for AIDS Relief (PEPFAR), InternaAonal Development Research Centre (IDRC), Council for ScienAfic and Industrial Research (CSIR) Swiss / South Africa iniAaAve and the Wellcome Trust
The SATuRN newsle0er is published as open access under a CreaAve Commons ShareAlike 30 Unported (CC BY-‐SA 30) license (h0p://creaAvecommonsorg/licenses/by-‐sa/30/) and is available in printed format as well as electronically as PDF, Web-‐format, etc The contents of this report and the opinions expressed herein are solely the responsibility of the authors and do not necessarily represent the official views or policies of any of the funders
SATuRN’s partners featured publica)ons!
Circula)ng Biomarkers of Immune Ac)va)on Dis)nguish Viral Suppression from Nonsuppression in HAART-‐Treated Pa)ents with Advanced HIV-‐1 Subtype C Infec)on. Malherbe G, Steel HC, Cassol S, de Oliveira T, Seebregts CJ, Anderson R, Cassol E, Rossouw TM Mediators Inflamm. (2014), 2014:198413:doi: 10.1155/2014/198413
Drug resistance among newly diagnosed HIV-‐infected children in the era of more efficacious an)retroviral prophylaxis Kuhn L, Hunt G, Technau KG, Coovadia A, Ledwaba J, Pickerill S, Penazzato M, Bertagnolio S, Mellins CA, Black V, Morris L, Abrams EJ, AIDS. 2014 Apr 30. [Epub ahead of print]
High-‐level cross-‐resistance to didanosine observed in South African children failing an abacavir-‐ or stavudine-‐based 1st-‐line regimen Steegen K, Levin L, Ketseoglou I, Bronze M, Papathanasopoulos MA, Carmona S, Stevens W, PLoS One. 2014 May 9;9(5):e97067. doi: 10.1371/journal.pone.0097067
Training course )tle, loca)on and date
Sep 2014
Oct 2014
19th Interna)onal Bioinforma)cs Workshop on Virus Evolu)on and Molecular Epidemiology NaAonal InsAtute for InfecAous Diseases "L Spallanzani", Rome, Italy, September 7-‐12, 2014
Annual Workshop on Advanced Clinical Care -‐ AIDS (AWACC) & SATuRN workshop 2014, Southern Sun Elangeni Hotel, Durban, South Africa, 8 and 9 October 2014.
SATuRN Newsle0er, vol 3, number 2, July 2014
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