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SAPONIN HOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA

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Page 1: SAPONIN HOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA

SAPONINHOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND

AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA

Page 2: SAPONIN HOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA

Quick Review

My hypothesis

Sources of saponin

Mechanism of saponin

Methods and vivo model

Page 3: SAPONIN HOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA

Structural Formula of Saponin (Reminder)

Page 4: SAPONIN HOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA

Hypothesis

Saponin can help in the reduction of the occurrence of asthma

Page 5: SAPONIN HOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA

Aim

To examine the design of my experiment To examine the model I would use in my experiment To examine the mechanism of saponin in lung tissues of a rabbit system in more detail

Expected results

Alternative approach in the treatment of Asthma

Page 6: SAPONIN HOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA

Design

Design: In my work, I have decided to use a rabbit for my experiment. I chose a rabbit because of its basic similarities of its body system to that of humans. In this experiment, I want to use 4 samples and compare its results for evaluation. Below is the basic design of my experiment.

Saponin + + - - Patient + - + -

Key:

Saponin: + means with saponin - means without saponin

Patient: + means sick patient - means healthy patient

Page 7: SAPONIN HOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA

Expected Result

For

Saponin + Patient +

In this case, when a sick patient takes saponin, the sick patient gets treated by the saponin through the mechanism described above.

For

Saponin + Patient -

In this case, when the patient is healthy and he takes saponin, it continues the normal action of providing nutrients to the body like Vitamin K, and also fight bacteria and enhance the growth of hair.

Page 8: SAPONIN HOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA

For

Saponin - Patient +

In this case, when a sick patient does not take saponin, he remains with the blocked lungs like that of Fig. D and the patient would continue having breathing problems.

For

Saponin - Patient -

In this case, when a healthy person does not take saponin, he would live his normal life without any problem.

Page 9: SAPONIN HOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA

Mechanism

Page 10: SAPONIN HOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA

Lung Tissues Of Two Vivo Models

Fig. A: Tissue of a healthy lung of a rabbit

Fig. B: Tissue of a smoked lung of a rabbit

Page 11: SAPONIN HOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA

Potential Problems of Saponin

it increases the latent period of asthma another serious problem caused by saponin is the fact that when it is induced into the

human body, it moves directly to the blood cells and causes haemolysis of the red blood cells.

Page 12: SAPONIN HOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA

Notes and Definition of Terms

The ability of saponin to increase the latent period of asthma depends on the dose of the saponin that is taken. Researchers have proven that if a dose of 20mg/kg is taken, it increases the latent period by about 29% and if a dose 40mg/kg is taken, it increases the latent period by about 49%.

Haemolysis: Breakdown or destruction of red blood cells so that the contained haemoglobin is freed into the surrounding medium

latency period is a period in which someone is infected with a disease, but no symptoms are observable

Free radicals are molecules produced when your body breaks down food, or by environmental exposures like tobacco smoke and radiation. Free radicals can damage cells, and may play a role in heart disease, cancer and other diseases.

Page 13: SAPONIN HOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA

Alternative Approach

Garlic can be an alternative approach to curing asthma.

One nutrient that plays a key role in the ability of garlic to fight asthma is vitamin C

Vitamin C helps neutralize free radicals, unstable molecules that cause contraction of airway smooth muscles in asthma sufferers

Vitamin C is an antioxidant

Antioxidants terminate chain reactions of free radicals by removing free radical intermediates, and inhibit other oxidation reactions. They do this by being oxidized themselves, so antioxidants are often reducing agents.

Page 14: SAPONIN HOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA

Anti-Oxidants Vs. Free Radicals

Page 15: SAPONIN HOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA

Conclusion

Saponin is used in the treatment of asthma, but it also has some setbacks like its level of toxicity making Garlics the best alternative in the treatment of asthma due to the fact that they are less toxic and very effective irrespective of the dose taken. Garlic is now used in the treatment of asthma for several years now and have proven to be very effective.

Page 16: SAPONIN HOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA

Reference

Adams NP, Bestall JC, Jones PW, Lasserson TJ, Griffiths B, Cates C. (2005). Inhaled fluticasone at different doses for chronic asthma in adults and children. Cochrane Database Syst Rev, 3.

Masoli M, Weatherall M, Holt S, Beasley R. (2004). Clinical dose-response relationship of fluticasone propionate in adults with asthma. Thorax, 59(1):16-20

http://www.ncbi.nlm.nih.gov/pubmed/14694240?dopt=Abstract

Chenghua. G, Xuexi .T, Xinwei. D and Yan.Y. (2009). African Journal of Biotechnology. Studies on the expectorant, antitussive and antiasthmatic properties of asterosaponin extracted from Luidia quinaria. 8 (23), 6694-6696.

http://www.ajol.info/index.php/ajb/article/viewFile/66384/54095

Ajibade V. A., Famurewa, O. (2012). Global Journal of Medical research. Histopathological and Toxicological effects of crude saponin extract from Phyllanthus niruri, L (Syn. P. franternus. Webster) on Organs in animal studies12 (1), 31-