Sample Drug Information Questions

Question 1

What medication is recommended for the initial

management of fibromyalgia syndrome?

Category of Question:

Therapeutic Management/Recommendation/Guidelines

Possible 3ry sources:

Uptodate, Evidence based Medicine Guidelines……………

Possible websites: Guidelines.gov, Tripdatabase.com

Question 1

Question 2

What topical medication is recommended for the initial management of uncomplicated catheter exit site infection in Haemodialysis patients?

Category of Question:

Therapeutic

Management/Recommendation/Guidelines

Possible 3ry sources:

Uptodate, Evidence based Medicine

Guidelines………

Possible websites: Guidelines.gov,

Tripdatabase.com

Question 2

Question 3

What is the dose of tiotropium bromide (Spiriva) for a

patient with chronic obstructive pulmonary disease??

Category of Question:

Dosing

Possible 3ry sources:

Drug information Handbook, AHFS, Handbook of

Clinical Drugs Data

Possible websites: Lexi-comp, Micromedex

Question 3

Question 4

• A 48 years old Patient is suffering from complicated UTI (Ht=175 cm, wt=100 kg), his SCr is stable around 3.5 mg/dl, after revising “Sanford guide for antimicrobial therapy” you selected ………… ………………

Question 4 (cont.)

• A 48 years old White Male Patient is suffering from complicated UTI (Ht=175 cm, wt=100 kg), his SCr is stable around 3.5 mg/dl, after revising “Sanford guide for antimicrobial therapy” you selected Levofloxacin(750mg/24h) which needs renal dose adjustment! ... What will you do?:// . . / .http www globalrph com crcl htm

Question 4 (cont.)

• Next day, His S.Cr. Jumped to 5 mg/dl ….modify the dose

:// . . / .http www globalrph com unstable htm

Question 4 (cont.)

• If the Patient is on HD, What is the recommended dose of levofloxacin

Question 5

• Based upon a blood culture, Tigecycline was selected to treat Community acquired pneumonia in a liver impaired patient, his total bilirubin is 4 mg/dl, albumin = 2, Prothrombin time = 23 sec, Severe Ascites and grade 3 hepatic encephalopathy.

Calculate Tigecycline dose for this patient.

Hepatic Functions

• Mild hepatic impairment = < 6 points.

• Moderate hepatic impairment = 6 – 10 points.

• Severe hepatic impairment = > 10 points.

Hepatic Functions

Child Pugh score ------- (8 – 9) needs (25 %) decrease in initial daily drug dosage for agents that are primarily (≥ 60%) hepatically metabolized.

Hepatic Functions

Child Pugh score (≥ 10) needs (50 %) decrease in initial daily dose for agents primarily hepatically metabolized.

Hepatic Functions

e.g. Rifampicin AND Propranolol

Question 6

• A 25 years Old Pregnant Woman is complaining of Sinusitis, her physician wants to give her desloratadine tablet but has no idea about its safety in pregnancy, What is your recommendation??

Drugs in Pregnancy and lactation

Question 7

• A 23 yrs breastfeeding woman was diagnosed with depression her physician wants to give her paroxetine, she is worried about its safety in lactation….What is your recommendation?

Question 7

http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT

Question 8

• A patient is receiving a continuous infusion of sodium bicarbonate. Amikacin is prescribed. Is amikacin compatible with sodium bicarbonate?

http://online.lexi.com/

Question 9

• You were astonished when you found Doxazosin in a urology consultant prescription for a non HTN female patient, what would be the possible indications for Doxazosin??

http://www.thecochranelibrary.com/view/0/index.html

Question 10

• What is the risk of telithromycin (Ketek)– associated liver failure?

Question 11

• What electrocardiogram changes are associated with amitriptyline toxicity?

Question 11

Question 12

• A Kidney posttransplant patient suffered from erectile dysfunction and topical candidiasis , his dermatologist wants to add sildenafil (viagra) and fluconazole (diflucan) to his medications. The patient is currently on ciclosporin, mycophenolate and prednisolone. What is your recommendation??

Question 12

Question 13

• A comatosed patient in the ICU is suffering from hypercholesterolemia, we want to add an HMGCo-A reductase inhibitor to his medications, which agent is more suitable??

Question 13

Take Away Case

• A patient with Pheochromocytoma, Candidate for unilateral adrenalectomy. What is the Pre-and Postoperative Drug Therapy Required?