salt kills the mission. coronary artery disease in indians in usa ( cadi )
TRANSCRIPT
SALT KILLS
The Mission
Coronary Artery Disease In Indians in USA ( CADI)
PUBLIC ENEMY # ONE
High blood pressureStrokeHeart diseaseObesityOsteoporosisAsthmaStomach cancerAnd of course, dementia 56 million Americans Affected
Salt and hypertension In 1952, Brookhaven's Lewis Dahl began his pioneering work connecting salt and hypertension. During 25 years of tests, he discovered that high salt intake was more dangerous in youth, and recommended that no salt should be added to baby foods. He also showed that a person's genetic background greatly affects their susceptibility to hypertension from salt.
Lewis K. Dahl
Salt Intake
B P
INTERSALT
AGE
BP
90/60
Yanomami Indians Range of BP and impact of age on BP
Jeremiah Stamler Father of Preventive Cardiology
“The INTERSALT study results, which agree with the findings from other
diverse studies, including data from clinical observations, therapeutic interventions, randomized controlled trial, animal experimentation, physiologic investigations, evolutionary biology research, anthropology research, and epidemiologic studies,
support the judgment that habitual high salt intake is one of the quantitatively important, preventable mass exposures causing the unfavorable population wide blood pressure pattern that is a major risk factor for epidemic cardiovascular disease.“……
…………….Stamler
“Ignoring the overwhelming scientific consensus on this issue…[is] supportive of positions adapted by special interests and comes at the expense of public health”.
Limit salt intake to 1500 mg a day
Institute of Medicine
STUDIES SUPPORT POPULATION BASED EFFORTS TO LOWER EXCESSIVE DIETARY SODIUM INTAKE
EVIDENCE SUPPORTS A POSITIVE RELATIONSHIP BETWEEN HIGHER LEVELS OF SODIUM INTAKE AND RISK OF HEART DISEASE, IS CONSISTENT WIH PREVIOUS RESEARCH BASED ON SODIUM EFFECTS ON BLOOD PRESSURE
MAY 14, 2013
1 MILLION people studied
Systolic Blood Pressure andRelative Cardiovascular Mortality Risk
Cardiovascular mortality doubles for each 20 mmHg increase in blood pressure
Systolic Blood Pressure115 135 155 175
Relative risk of cardiovascular mortality at prehypertension (systolic blood pressure of 140 mmHg)
• One billion People with High blood pressure…..WHO• Nine out Ten People do not Follow salt reduction…CDC• Salt Content of Processed food unchanged…Multiple Sources
Cardiac Hypertrophy From Fighting Hypertension
Mitral Regurg From Hypertensive Cardiomyopathy
High blood pressure Cholesterol
build up in the arteries
Heart muscle overgrowth
Heart attacks Loss of
heart muscle
Diastolic dysfunction
Systolic dysfunction
Heart Failure
Both
SALT
Diastolic DysfunctionLessons From ADHERE
(Acute Decompensated Heart Failure Registry)
• Over 5 Million Americans living with Heart Failure
• 250,000 Deaths per year• 500,000 new cases per year• 33% die within the first diagnosis• Systolic function preserved in nearly half the
patients• Number One Reason for Hospitalization
OSTEOPOROSIS FRACTURE
Greater than combined risk of Breast and Ovarian Cancers
Prostate cancer(1 in 3 women and 1in 5 men)
STROKE
Mechanisms of Dementia
High blood pressure Increases the risk of memory loss by
600%
Auto-Immune Disease
If you incrementally increase salt, you get generation after generation
of these TH17 cells….Vijay Kucheroo
SALT KILLS
The Mission