sakarya university department of chemistry...department of chemistry international turkic world...

SAKARYA UNIVERSITY

FACULTY OF SCIENCE AND ARTS

DEPARTMENT OF CHEMISTRY

INTERNATIONAL TURKIC WORLD CONFERANCE ON CHEMICAL SCIENCES AND TECHNOLOGIES

(ITWCCST)

27th OCTOBER-1st NOVEMBER

2015

SARAJEVO

BOSNIA-HERZEGOVINA

Chair of the Conference

Prof. Dr. Ahmet TUTAR

Congress Secretary

Prof. Dr. Ahmet TUTAR Sakarya University

Musa Köse Zenith Group D.O.O. Sarajevo, Bosnia and Herzegovina

Hana Sarkinovic Zenith Group D.O.O. Sarajevo, Bosnia and Herzegovina

İsmet Uzun Balkan Research and Development Center / BALDER, Sarajevo, Bosnia and Herzegovina

Organization Committee

Prof. Dr. Ahmet TUTAR Sakarya University,

Prof. Dr. Prof. Dr. Mehmet Hakkı ALMA Kahramanmaraş Sütçü İmam University

Prof. Dr. Ahmet AYAR Sakarya University

Assoc. Prof. Dr. Hüseyin ALTUNDAĞ Sakarya University

Assist. Prof. Dr. Mustafa AKÇİL Sakarya University

Assist. Prof. Dr. Beytullah EREN Sakarya University

Assist. Prof. Dr. Murat TUNA Sakarya University

Assist. Prof. Dr. Ertuğrul ALTUNTAŞ Kahramanmaraş Sütçü İmam University

Research Assist. Eyyüp KARAOĞUL Kahramanmaraş Sütçü İmam University

Research Assist. Tufan SALAN Kahramanmaraş Sütçü İmam University

Raşit Fikret YILMAZ Sakarya University

İbrahim Halil BAYDİLEK Sakarya University

Ömer Faruk TUTAR Sakarya University

Research Assist. Yavuz DERİN Sakarya University

Scientific Committee

Prof. Dr. Abdolali AlEMİ Tabriz University

Prof. Dr. Abdurrahim KOÇYİĞİT Bezmialem Vakıf University

Prof. Dr. Abel Maharramow Bakü State University

Prof. Dr. Ahmed KAYACIER Bursa Technical University

Prof. Dr. Ahmet TUTAR Sakarya University

Prof. Dr. Arif DAŞTAN Atatürk University

Prof. Dr. Akif AZİZOV Azerbaijan National Academy of Sciences

Prof. Dr. Bagher EFTEKHARI-SIS University of Maragheh

Prof. Dr. Bolat URALBEKOV El-Farabi Kazak National University

Prof. Dr. Dilgam TAGİYEV Azerbaijan National Academy of Sciences

Prof. Dr. Erdoğan KÜÇÜKÖNER Süleyman Demirel University

Prof. Dr. Farid YAMBUŞEV Kazan Federal University

Prof. Dr. Farida KARATAEVA Kazan Federal University

Prof. Dr. Florida KUDASHEVA Bashkir Government University

Prof. Dr. Hacali NECEFOĞLU Kafkas University

Prof. Dr. Harun PARLAR Munich University

Prof. Dr. Hüseyin KARA Selçuk University

Prof. Dr. İlyas NİZAMOV Kazan Federal University

Prof. Dr. İsmet KAYA Çanakkale Onsekiz Mart University

Prof. Dr. Mahammed BABANLİ Azerbaijan National Academy of Sciences

Prof. Dr. Mehmet Akalin Marmara University

Prof. Dr. Mehmet Hakkı ALMA Kahramanmaraş Sütçü İmam University

Prof. Dr. Mehmet SÖNMEZ Gaziantep University

Prof. Dr. Mohammed Taghi ZAFARANİ-MOATTAR Tabriz University

Prof. Dr. Muhammet ARİCİ Yıldız Technical University

Prof. Dr. Mustafa SÖZBİLİR Atatürk University

Prof. Dr. Naz Mohammed ATABAY Fatih University

Prof. Dr. Osman SAĞDIÇ Yıldız Technical University

Prof. Dr. Rinat AKHMETKHANOV Bashkir University

Prof. Dr. Rustem AMİROV Kazan Federal University

Prof. Dr. Sluken RAKHMADİEVA L.N. Gumilev Eurasia National University

Prof. Dr. Tofik NAGİYEV Azerbaijan National Academy of Sciences

Prof. Dr. Yerdos ONGARBAYEV El-Farabi Kazak National University

Prof. Dr. Sharipa JOROBEKOVA Kirgizstan National Sciences Academia

Prof. Dr. Vagif ABBASOV Azerbaijan National Academy of Sciences

Prof. Dr. Vagif FARZALİYEV Azerbaijan National Academy of Sciences

Prof. Dr. Yücel KADIOĞLU Erzincan University

Assoc. Prof. Dr. İsmail Usta Marmara University

Assoc. Prof. Dr. Muhammet Uzun RWTH Aachen University

ii

Dear Scientist;

The first International Turkish World Chemical Sciences and Technology Conference was organized by collaboration of Sakarya University Chemistry Department and Kahramanmaraş Sütçü Imam University. The conference was held and hosted by International University of Sarajevo. We are very happy for organizing this conference in such a beautiful country that we have strong historical ties and also we are very happy for being hosted in one of the beautiful university located in beautiful city of Sarajevo. I offer all my separate gratitude the authorities of International University of Sarajevo for opening their doors to us and hosting us with their sincerity.

Chemistry is not only fundamental science but also has interdisciplinary relations like health, agriculture and engineering science. The technological and scientific developments eliminate the sharp lines among the branches of science. Any new development in science will affect the whole science world and we believe that chemistry has a privilege among them. Thus, chemistry has broader applications and intersects with many other of them. As all we know, one of the recent news made us all proud. 2015 Nobel Prize in chemistry was given to three professor and one of them was a Turkish scientist Dr. Aziz Sancar. Although, he is in health science area his prize is given for his chemical studies and his prize made all Turkish world and Islamic world proud of him. The First Turkish World Chemistry conference was held at same time with Dr Sancars prize that was also very nice and flattering coincidence. Undoubtedly his great success for us and especially for young people will be very important encouragement. I congratulate Prof. Dr. Aziz Sancar again and I give my respect to him.

We wanted to make this conference little bit special by bringing scientist together from different disciplines of chemistry and also to open new research fields for them. In this sense, we desired to bring the distinguished scientist of Turkish world together to get know each other and to develop and implement new joint projects. The Turkish World conference was held the first time, for this reason, we could not bring most of the Turkish World scientist together. We hope to bring more scientist together in the future congress. The scientist joined the conference was from 22 different country and mostly from Turkey and Azerbaijan. Total 586 scientist, educator, and industrialist and from other fields were registered in the conference. The total number of submission were 386 and after a careful evaluation 354 submissions were accepted by our scientific committee and 224 of them were accepted as poster presentation and 130 of them were accepted as oral presentation and abstract part of all those presentation was taken place in the conference booklet.

We would like to thank to Rector of Sakarya University Prof. Dr. Muzaffer ELMAS for giving us permission and also supporting us both financially and morally and also we thank to the Dean of Faculty of Arts and Science of Sakarya University Prof. Dr. Yilmaz DAŞÇIOĞLU. We would like to thank to Kahramanmaraş Sütçü İmam University and Prof. Dr. Hakkı ALMA for willing to be together with us. We would like to send our special thanks to Mr. Musa Köse, ZENITH Group workers for their special efforts. We would like to also thank to Prof. Dr. Arif DAŞTAN, Prof. Dr. Dilgam TAGIYEV’e, Prof. Dr. Hacali NECEFOĞLU’na, Prof. Dr. Mahammed BABANLY and my forever friend Famil VALİYEV for their special supports to make this congress possible. And the most importantly I would like to thank to all the participants individually who came from far away to join this conference.

Prof. Dr. Ahmet TUTAR

iii

CONTENTS

FOREWORD ii CONTENT iii POSTER PRESENTATION 1 OR-1 Sulphur-Containing Antioxidants of Combined Action

Vagif M. FARZALIYEV 2

OR-2 New Reactions of Acetylenes: An Unexpected Easy Full Cleavage of Polarized C≡C

Moiety Under Action of N-Nucleophiles Sergey VASILEVSKY, Maria DAVYDOVA

3

OR-3 Synthesis and Crystal Structure of 4,5,12,13-Tetraaza dibenzo[b,k]chrysene Famil VALIYEV

4

OR-4 Organic Synthesis in Glycerol Based Solvents Adi WOLFSON, Dorith TAVOR

5

OR-5 Photobactericidal and Photochromic Textile Materials Realized by Embedding of Advantageous Dye Using Sol-gel Technology Boris MAHLTIG, Torsten TEXTOR, Perrin AKÇAKOCA KUMBASAR

6

OR-6 An Investigation on Serum Levels of Cu, Zn, Ca, Mg and P in Goats İlker CAMKERTEN, Güzin CAMKERTEN, Osman KARABULUT, Durhasan MUNDAN,Gaye BULUT

7

OR-7 Antioxidant Capacity of Verbascoside Isolated from Teucrium chamaedrys L. subsp. Chamaedrys Mahfuz ELMASTAŞ, Beşir İSNAÇ, Ayşenur TAŞ, Hüseyin AKŞİT, Nusret GENÇ

8

OR-8 Secondary Metabolites from Origanum rotundifolium Boiss. and Antioxidant Activities Ramazan ERENLER, Özkan ŞEN

9

OR-9 Separation and Preconcentration of Palladium on Magnetic Polyhydroxybutyrate-b-Polydimethylsiloxane (PHB-b-PDMS) and its Determination in Environmental Samples by Flame Atomic Absorption Spectrometry Mustafa TÜZEN, Yunus Emre ÜNSAL, Mustafa SOYLAK, Baki HAZER

10

OR-10 Conversion Treatment of Thin Chromium Layers Deposited on High Carbon Steels Substrates Younes BENARIOUA

11

OR-11 Evaluation of the Raman Spectroscopy Coupled with Partial Least Squares Regression Analysis for Diagnosis of Hepatitis C. H. NAWAZ, N. RASHID, M. BILAL, M. SALEEM, I. AMIN, M. IGBAL, M. RAHMAN, P. KNIEF, H J BYRNE, S. M. BAIG, M. AHMED

12

OR-12 Kendiliğinden Yerleşen Betonda Rötre Azaltıcı Kimyasal Katkının Dayanıma Olan Etkisi İlhami DEMİR, İlker KALKAN, Ali Payidar AKGÜNGÖR, Özer SEVİM

13

OR-13 Spectroscopic Studies on 9H-Carbazole-9-(4-phenyl) Boronic Acid Pinacol Ester by DFT Method Emine BABUR ŞAŞ, Mustafa KURT, Mustafa CAN, Nesrin HORZUM, Ahmet ATAÇ

14

OR-14 Efficient Synthesis of Indene-Aldehyde Derivatives Catalyzed by Secondary Amine Catalysts Hui MAO, Jung Woon YANGA

15

iv

OR-15 Synthesis of Multiwall Carbon Nanotube -p-Phenylenediamine - Maleic Anhydride -1-Heptene Nanocomposite Elvin MALIKOV, Oktay AKPEROV, Mustafa MURADOV, Goncha EYVAZOVA

16

OR-16 Design of an Appropriate Semi-Interpenetrating and Full-Interpenetrating Polymer Network Chitosan for Nano Drug Delivery; Review Amilah, Nike Triendah ASIH

17

OR-17 Preparation of Chitosan-Gum Arabic/N-Eicosane Microcapsules by Complex Coacervation Kasım AKSOY, Cemil ALKAN

18

OR-18 Removal of Cr(III) and Cr(VI) Ions from Aqueous Solutions Using Modified Cotton Cellulose with Polycarboxylic Acids Nazife KORKMAZ, Sennur ALAY AKSOY, Fethiye GÖDE

19

OR-19 Oxidative Stress Parameters in Anesthetized with Ketamine-Xylazine the Bozova Greyhounds Güzin CAMKERTEN, İlker CAMKERTEN, Nihat ŞINDAK, GayeBULUT

20

OR-20 Structural, Electronic, Elastic and Phonon Properties of OsAl in B2 Crystal Structure from First-principles Raşit UMUCU, Mustafa ÖZDURAN

21

OR -21 Thermal Energy Storage Properties of Poly(methyl methacrylate)/Stearic Acid Micro/Nano Capsules Ahmet SARI,Ayşe Gül KÜÇCÜK, Alper BİÇER, Cemil ALKAN

22

OR -22 AB Initio Molecular Dynamics Study of Structural Properties of FeF2 as a Function of Pressure Cihan KÜRKÇÜ, Ziya MERDAN, Hülya ÖZTÜRK, Sümeyra YAMÇIÇIER, Çağatay YAMÇIÇIER, Cemile KÜRKÇÜ

23

OR -23 Developed of Potentiometric Sensitive Sensor to Antipsychotic Risperidone Ömer IŞILDAK, Ayşenur BİRİNCİ

24

OR-24 Usability and Attenuation Performance of Titanium-Iron Oxide Mineral as Natural Filler for Composite Ionizing Electromagnetic Radiation Shielding Ezgi Eren BELGİN, Gül Asiye AYÇIK, Ayşe KALEMTAŞ

25

OR-25 Synthesis of Some Natural Bromophenols Including Propane Derivatives Çetin BAYRAK, Abdullah MENZEK

26

OR-26 From “Dark to light”1-2 to Fluorescence Resonance Energy Transfer: Dual Activator TPE Donor Fused BODIPY Dyes with a Large Stokes Shift and High Quantum Yield Esra ŞEN, Serdar ATILGAN, Kadem MERAL

27

OR -27 Synthesis of The Topoisomerase-I Inhibitors Isoindolo[2,1-B]-Isoquinolin-7(5H)-one and The Alkaloid Rosettacin Based on Aryl Radical Cyclization and N-Acyliminium Chemistry Lahssen El BLIDI, Adam DAICH, Yousef AL-ZEGHAYER

28

OR -28 Determination of Structural and Spectroscopic Properties of Methyl-4-bromo-2-chloropyrıdine-3-carboxylate Molecule Using FT-IR and NMR Experimental Techniques and DFT Quantum Chemical Calculations Zühre CALIŞIR, Mustafa KURT, Mehmet KARABACAK, Ahmet ATAÇ

29

OR -30 A New Approach to Convenient Synthesis of Disubstituted Tacrine Derivatives Makbule EKİZ, Ahmet TUTAR, Salih ÖKTEN

30

OR -31 Chitosan/Nanoclay/n-Eicosane Microcapsules with Heat Energy Storage Property Ebru GENÇ, Sennur ALAY AKSOY, Kasım AKSOY

31

v

OR -32 ab initio Study of Elastic, Electronic and Phonon Properties of SnNCa3 and PNCa3 Compounds Mustafa ÖZDURAN and Raşit UMUCU

32

OR -33 The Trace Elements (Selenium, Copper, Zink, Iron) Levels in Patients Sera Affected by Bovine Ephemeral Fever Hikmet ÜN, Güzin CAMKERTEN, İker CAMKERTEN, Tekin ŞAHİN, Burcu M.

BALKAN, Özcan EREL

33

OR -34 Comparison of Phenolic Compounds in Commercial Bee Pollen and Pollen Inside the Hive Yaşar GÜLMEZ, Ömer KAYIR, Mahfuz ELMASTAŞ

34

OR -35 Conductance and Thermodynamic Study of Cobalt (II), Nickel (II) and Copper (II) Complexes with a New Schiff Base Derived from 1,8-Diaminonaphthalene Taher Sh. ABABNEH, Taghreed M. A. JAZZAZI, Tareq M. A. Al SHBOUL, Ziyad A. TAHA

35

OR -36 Calcination of Galvaniz Ash and Investigation of It’s Resolution in Acid Leaching Solutions Harun YILMAZ

36

OR -37 Electronic, Elastic, Thermodynamic and Phonon Properties of LaCd and LaCo Compounds in the B2 Phase Osman ÖRNEK, Nihat ARIKAN, Şule UĞUR, Gökay UĞUR

37

OR -38 Kendiliğinden Yerleşen Betonda Hidratasyon Isısı Azaltıcı Kimyasal Katkının Dayanıma

Olan Etkisi İlker KALKAN, İlhami DEMİR, Ali Payidar AKGÜNGÖR, Özer SEVİM

38

OR -39 Anions Content of Wild Grown Edible Mushrooms Species in Ordu Region, Turkey İbrahim TÜRKEKUL, Ömer IŞILDAK

39

OR -40 ICG-Conjugated Magnetic Graphene Oxide for Dual Photothermal and Photodynamic Therapy Nuran IŞIKLAN, İsmail ÖÇSOY, Nalan ÖZDEMİR

40

OR -41 Comparison of Photo Physical Properties of 7-diethylamino-3-thenoyl Coumarin and 7-diethylamino Coumarin Dr. Sanjay KUMAR

41

OR -42 Synthesis and Solid State Self-assembly of Thiosemicarbazones Highlighting Their Potential in Crystal Engineering Muhammad Moazzam NASEER

42

OR -43 Synthesis of the Efficient Palladium Catalysts for the Cross-coupling Reactions and Hydrogenation by the Direct Loading of Inorganic Supports Using Stable Pd(0) Source Viacheslav I. SOKOLOV, Natalya V. ABRAMOVA

43

OR -44 Synthesis of Methyl-Substituted Mono- and Di-Methoxy Conduritols Dilek KAPLAN, Latif KELEBEKLİ

44

OR -45 Structure Activity Relationship Studies of Novel Quinoline Derivatives as Anticancer Agents Salih ÖKTEN, Osman ÇAKMAK, Şaban TEKİN

45

OR -46 The Investigation Of Menthol’s Bioactivity In Blood As Theoritical By Using DFT

(Density Functional Theory) Faik GÖKALP

46

OR -47 Use of Supramolecular Solvents for Liquid Phase Microextraction of Gold(III) from Environmental Sampled ErkanYILMAZ, Mustafa SOYLAK

47

vi

OR -48 Facile and Large Scale Synthesis of Graphene Tugay ÜSTÜN, Havva Tutar KAHRAMAN, Ahmet AVCI, Erol PEHLİVAN

48

OR -49 Fabrication of Thermo-regulated PAN/ Myristic asid (MA) Nanofibers by the Electrospinning Process M.Selda TÖZÜM, Sena DEMİRBAĞ, Kasım AKSOY

49

OR -50 Kendiliğinden Yerleşen Betonda Piriz Hızlandırıcı Kimyasal Katkının Dayanıma Olan

Etkisi Ali Payidar AKGÜNGÖR, Özer SEVİM, İlhami DEMİR, İlker KALKAN

50

OR -51 Density Functional Theory and ab initio Hartree-Fock Calculations of Molecular Structure and Conformational Properties of 4-X-Phenylboronic Acid Derivatives ( X = F, Cl, Br) Güventürk UĞURLU

51

OR -52 Electronic Structure, Elastic and Phonon Properties of Rh3La Compound: An ab initio Study Nihat ARIKAN, Osman ÖRNEK, Şule UĞUR, Gökay UĞUR

52

OR -53 Production of Heat Energy Storage PAN/PEG Nanofibers Sena DEMİRBAĞ, Kasım AKSOY, M.Selda TÖZÜM

53

OR-54 Cost-Effective Graphene Coated Polyurethane Sponge for Oil/Water Separation Havva Tutar KAHRAMAN, Tugay ÜSTÜN, Erol PEHLİVAN, Ahmet AVCI

54

OR-55 Synthesis and Application of Nano-Metal Catalysts by Metal Vapor Method Vagif AKHMEDOV, Dilgem TAGIYEV

55

OR-56 Characterisation of Graphene Oxide/Poly(Acrylonitrile-Vinyl Acetate) Nanocomposites Produced by Electrospinning Method Mustafa YAZICI, İsmail TİYEK, M. Hakkı ALMA, Utkay DÖNMEZ, Behzat YILDIRIM, İbrahim KARTERİ, Tufan SALAN, Serhan URUŞ, Şükrü KARATAŞ, M. Sabri ERSOY

56

OR-57 Supercapacitor Electrode Materials of Novel Synthesized Polymer/Carbon Nanotube Composite Materials Murat ATEŞ, Nesimi ULUDAĞ

57

OR-58 Linear Pentanuclear Nickel Complex with Pyrazine Modulated N,N’-di(pyrazin-2-yl)pyridine-2,6-diamine Ligand Rayyat Huseyn ISMAYILOV, Fuad Famil VALIYEV, Wen-Zhen WANG, Gene-Hsiang LEE, Shie-Ming PENG

58

OR-59 Key Magnetic Intermediates in Mo-, W-, Re- based Catalytic Systems for Olefins Metathesis Reactions: Structure and Reactivity Yadigar ABBASOV, Etibar ISMAILOV, Dilgam TAGIYEV

59

OR-60 Determination Optimum B2O3, KCl and NaOH Molar Ratios in the Synthesis of Potassium Borates Seyhun KIPÇAK, Merve GÜNAL, Sibel ILA, Meral YILDIRIM, Mehmet B. PİŞKİN, Emek MOROYDOR DERUN

60

OR-61 Determination of Metal Content in the Water and Sediments Located Around Siirt İbrahim TEGİN, Uyan YÜKSEL

61

OR-62 Determination of Nitrate, Fluoride and Methyl Tertiary-buty Ether by Aqueous Solution Using Amin Multi Walled Carbon Nanotubes Hamideh YAHYAPOUR, Omid MORADI

62

vii

OR-63 The Hydrogenation of Carbon Dioxide over Nanostructured Zr/Si Oxide Contacts Shaxla TAGIYEVA, Nushaba ALIYEVA, Lala QASIMOVA, Etibar ISMAILOV

63

OR-64 Absorbtion Cooling Systems for Ships Mesut TANER

64

OR-65 Boric Acid Production From Sodium Metaborate With Sulphuric Acid Hilal Seda DEMİREL, Taylan Efe İNCE, Duygu UYSAL, Bekir Zühtü UYSAL

65

OR-66 Effect of Aqueous Extracts of Leaves, Seeds and Stem Bark of Moringa oleifera on Spme Bacteria and Fungi Isolated From Spoilt Locally Produced Soymilk Abiona Dupe LYDIA, Adegbola Racheal ADEBOLA, Olanrewaju Bernice JEJELOLA

66

OR-67 Characterization of Biosensor Application By Atomic Force Microscope (AFM): Modification of Gold Screen Surface By Dendrimeric Structures and Biological Molecules Dilek GÜNGÖR

67

OR-68 Magnetic Properties of Self-Assembled Magnetite Nanoparticles via Spin and Dip Coating Methods Sinem ESİR, Ayşe Demir KORKMAZ, Hüseyin KAVAS

68

OR-69 Liquifying Slimes and Some Oxidized Lignites Mehmet ÇÖTELİ, Akan GÜLMEZ, Ayşe ERDEM, Mehmet KARAKAŞ, Abdullah

ULAŞ, Selami TOPRAK, Emine SÜTÇÜ, Polat CANDAN

69

OR-70 Synthesis and Investigation of Their Antimicrobial Activities of New Conazole Derivatives Containing Morpholine and Fluorophenilene Rings Hacer BAYRAK, Yıldız UYGUN, Arif MERMER, Serap BAŞOĞLU, Neslihan

DEMİRBAŞ, Ahmet DEMİRBAŞ, Şule CEYLAN, Serpil DEMİRCİ

70

OR-71 Synthesis and Characterization of Green Polyurethanes Using Novel Vegetable Based Polyols Kemal KARADENİZ, Yakup ÇALIKOĞLU

71

OR-72 Comparison of %1 Nd and %1 Pr Doped %25 TiO2-MMT Composite Photocatalyst Amount on Azo Dye ( Basic Yellow 28) Oxidation Başak OTSUKARCI, Yasemen KALPAKLI

72

OR-73 The Synthesis of MSU-X Mesoporous Materials from Sodium Silicate Nevin KARAMAHMUT MERMER, Sevil Begüm KARAKAŞ, Müge SARI YILMAZ

73

OR-74 The Effect of Acid Concentration on the Synthesis of Hydrophobic Silica Based Aerogels Müge SARI YILMAZ, Özgül DERE ÖZDEMİR, Nevin KARAMAHMUT MERMER, Mehmet Burçin PİŞKİN

74

OR-75 Optimum Conditions for Chromatographic Seperation of N-Nitrosodiphenylamine from Its Intermediates Sinem DEMIR, Murat TORUN, Dilek ŞOLPAN

75

OR-76 Extraction, Characterization and Fatty Acid Profile of African Star Apple Seed (Chrysophyllum albidum) Oil Chidimma Emmanuel OMINYI

76

OR-77 Vesicular Coacervative Microextraction of Pb: Green Alternative to Classical Extraction Strategies Faheem SHAH, Tasneem Gul KAZI, Naeem ULLAH

77

viii

OR-78 Transformation of Liquefied Gases of Catalytic Cracking in the Presence of Polymer-Supported Ionic Liquid Systems Reyhan ALIYEVA, Yeter MAMMADOVA

78

OR-79 Leaching Kinetics of Zn from Zinc Plant Residue by Atmospheric and High-temperature H2SO4 Leaching Mehmet ERDEM, Mehmet ŞAHİN

79

OR-80 Fast Oxidation and Optimization of some Lignite Samples by means of Acid Leaching Haydar POLAT, Mehmet ÇÖTELİ, ehmet KARAKAŞ, Ayça YILDIRIM,

Polat CANDAN

80

OR-81 Analytical Investigation of a New Sandwich Type Phthalocyanine and Oncogene Interaction Esra BAĞDA, Ebru YABAŞ, Efkan BAĞDA

81

OR-82 Turkish Primary Science Teacher Candidates’ Understandings of Some Environmental

Problems Fatma AĞGÜL YALÇIN, Mehmet YALÇIN

82

OR-83 Effects of K+/Mn3+ Addition on Microstructure of SrTiO3 Ceramics Selvin USTABAŞ, Zeki AYDIN, H. Zehra AKBAŞ, Muhammet DEMİREL

83

OR-84 Solid-Liquid Extraction (Leaching) of Liquorice (Glycyrrhıza Glabra) İrem KARAASLAN, Zeki AYDIN, Ali Coşkun DALIÇ

84

OR-85 Synthesis and Antimicrobial Evaluation of Nalidixic Acid Based 1,2,4-Triazole Derivatives Şule CEYLAN, Neslihan DEMİRBAŞ, Hacer BAYRAK, Yıldız UYGUN, Serap

BAŞOĞLU, Ahmet DEMİRBAŞ

85

OR-86 Bio-synthesis of Cu- Nanoparticles Using Natural Plant Calotropis Extract as Reducing Agent for Enhanced Antibacterial and Antifungal Activity Muhammad Imran DIN

86

OR-87 Silver(I)-N-Heterocyclic Carbene Catalyzed Multicomponent One-pot Reactions: A Facile Synthesis of Highly Functionalized Pyrrole-3-carbonitriles Srinivas NERELLA

87

OR-88 Synthesis and Evaluation of Antitumor Activities of Novel Fused Uracil Derivatives Samar A. EL-KALYOUBI, Eman A. FAYED

88

OR-89 Comparison of Cold and Hot Esterification Methods of Fatty Acids for GC-MS Analysis Muhammet DEMİREL, Zeki AYDIN, Selvin USTABAŞ

89

OR-90 Cr(VI) Removal from Aqueous Solutions by Activated Carbon Prepared from Grape Stalk Mehmet ERDEM, Özlem AKÇAKAL, Hatice ERDEM, Mehmet ŞAHİN

90

OR-91 Utilization of Bergama Gold Tailings as an Additive in the Mortar Kübra KUNT, Meral YILDIRIM, Fatma DUR, Emek MOROYDOR DERUN, Sabriye PİŞKİN

91

OR-92 The Investigation of the Element Contents in the Turkish Coffees Nigar SELVİ, A.Seyhun KIPÇAK, Funda DEMİR, Özgül D. ÖZDEMİR, Mehmet

B. PİŞKİN, Emek M. DERUN

92

OR-93 Microwave Dehydration Behaviour of Inderite and Comparison with Thermal Analyses Methods İklim N. OZDOGAN, Yasemen T. AKSOY, F. Tuğçe ŞENBERBER, A. Seyhun KIPÇAK, Mehmet B. PİŞKİN, Emek MOROYDOR DERUN

93

ix

OR-94 Utilization of Boron Waste as an Additive for Cement Production Kübra KUNT, Fatma DUR, Beril ERTINMAZ, Meral YILDIRIM, Emek MOROYDOR DERUN, Sabriye PİŞKİN

94

OR-95 New Approach to Modelling of Discontinuous Azeotropic Distillation in Non-Conventional Configurations Marija STOJKOVIC

95

OR-96 About Evaluation in Chemistry Education Meliha ZEJNILAGIC-HAIRIC

96

OR-97 The Use of Mathematical Softwares in Chemistry Education Mehmet YALÇIN, Fatma AĞGÜL YALÇIN, Halil ZEHİR, Kıymet ZEHİR

97

OR-98 Corrosion Inhibition of Low Carbon Steel by Boron-Containing Ionic Liquids in 0.1 M HCl Hüsnü GERENGİ, H.İbrahim UĞRAŞ, Mine KURTAY, Necip ATAR

98

OR-99 Investigation Corrosion Effect of KBF4 on Low Carbon Steel by Dynamic Electrochemical Impedance Spectroscopy (DEIS) Hüsnü GERENGİ, H.İbrahim UĞRAŞ, Mine KURTAY

99

OR-100 Removal of Endocrine Disrupting Chemicals in Aqueous Solutions by Gamma-irradiation Masoomeh MEHRNIA, Sinem DEMİR, Murat TORUN, Dilek ŞOLPAN

100

OR-101 Synthesis of Bisbenzoin End-Functionalized Poly(e-Caprolactone) Macrophoto Initiator and Its Use in Miktoarm Star Copolymerization Zafer UYAR, Ülkü ARSLAN, Mustafa DEĞİRMENCİ

101

OR-102 Synthesis and Photochromic Properties of 4,5-Bisaryl-3(2H)-Pyridazinones Leyla GÜNDOĞDU, Ersin ORHAN, Mahmut KÖSE

102

OR-103 Antioxidant and Anticholinesterase Activity Evaluation of Various Fraction of Sarcosphaera crassa (santi) Pauzar: A Poisonous Edible Mushroom Zain ULLAH, Mehmet ÖZTÜRK, Mehmet Emin DURU, Yunus ÇETİNTAŞ

103

OR-104 Biological Activities and Chemical Composition of Essential Oil of Endemic Rhantheriumsuaveolens Desf.from Algerian Sahara Ahmed Elkhalifa CHEMSA, Ebru EROL, Mehmet ÖZTÜRK, Amar ZELLAGUI, Özgür CEYLAN, Noureddine GHERRAF, Mehmet E. DURU

104

OR-105 Study of Thermal Behavior of Nanocomposite Base on Aniline and Multi Walled Carbon Nanotube: Effect of Size Carbon Nanotube on Thermal Stability Shima moradi SEYMOHAMMADI, Omid MORADI

105

OR-106 Investigation of Corrosion Behavior of the DP600 Steel and AA5754 Aluminum Alloy Materials Joined Using Friction Stir Welding Method Ramazan SAMUR

106

OR-107 Catalytic Pyrolysis of Isochrysis Microalgae by Ceria Based Catalysts for Hydrocarbon Production Tevfik AYSU, Aimaro SANNA

107

OR-108 Proximate, Mineral Composition and Photochemicals Screening of Some Selected Spices Of Ibadan Metropolis, Oyo State, Southwest, Nigeria Adegbola Rachael ADEBOLA, Davies Caleb ADEOSUN, Abiona Dupe LYDIA

108

OR-109 AP-TPR-TD-GC/MS Study of Miocene-aged Lignite Humic Acids, Bulgaria Maya STEFANOVA, Lenia GONSALVESH, Stefan MARINOV, Jan CZECH, Robert CARLEER, Jan YPERMAN

109

x

OR-110 Rhizopogonroseolus and its Bioassay-guided Mycochemical Investigations Akhtar MUHAMMAD, Mehmet ÖZTÜRK, Mehmet Emin DURU, Aziz TÜRKOĞLU

110

OR-111 Investigation of Leaching Performance of Wood Materials Colored With Juglans Regia L. Osman GÖKTAŞ, Ertan ÖZEN, Mehmet YENİOCAK, Mehmet ÇOLAK, Mehmet

UĞURLU, Sevil YENİOCAK

111

OR-112 Determination of Vitamin A and E using the High Performance Liquid Chromatography in Medicinal Plants Suat EKİN, Mahire BAYRAMOĞLU, Hatice KIZILTAŞ, Fevzi ÖZGÖKÇE

112

OR-113 An Experimental Study on the Effect of Sonication Time on Viscosity and Fire Resistance Performance of Nanoclay-based Intumescent Coating Havva Tutar KAHRAMAN, Erol PEHLİVAN, Dilhan M. KALYON

113

OR-114 Alteration in the Nutritional Components of Trigonella foenum graecum Linn. Seeds During Various Germination Phases Iffat Zareen AHMAD

114

OR-115 CoxPty Nanoclusters Supported on Magnesia Surface; Preparation, Characterization and the Investigation of the Catalytic Performance in the Dehydrogenation of Aqueous Hydrazine Borane Şerif SAĞLAM, Gökhan YEĞİNER, Mehmet GÜLCAN, Mehmet ZAHMAKIRAN

115

OR-116 Expedient and Efficient Synthesis of Trifluoroethyl Ethers From Metal Free Reagent 2,4,6-tris-(2,2,2-Trifluoro-Ethoxy)-[1,3,5] Triazene Shrawan Kumar MANGAWA, Satish K. AWASTHI

116

OR-117 Cobalt Boron Nitride: A Novel Heterogeneous Catalyst for the Synthesis of Medicinally Important α-amino Quinoline Phosphonates Mahalingam SURESKUMAR, Krishnan ANAND, Thangaraj MUTHU, Robert Moonsamy GENGAN

117

OR-118 Hydrothermal Synthesized Nanocrystalline V2O5 and Electrical Properties Hasan GÖÇMEZ, Mustafa TUNCER, Seher ÇETİN, Faruk EBEOĞLUGİL

118

OR-119 Optimization of Production of Sodium Pentaborate from Ulexite Ore and Sulfur Dioxide Mehmet Muhtar KOCAKERİM, Vedat Arda KÜÇÜK

119

OR-120 Propericiazine as a Selective and Sensitive Reagent For The Spectrophotometric Determination of Microgram Amounts of Platinum in Minerals A. Thimme GOWDA

120

OR-121 Synthesis of Dihydropyrimidine Compounds by Biginelli Reaction and Performing the Eschenmoser Coupling Reaction Esvet AKBAŞ, Erdem ERGAN

121

OR-122 Selective Separation of Alkyl Tert-alkyl Ethers from Alcohol and Hydrocarbons Containing Azeotropic Mixture by Ionic Liquids Akif AZIZOV, Hamide AZIZBEYLI, Reyhan ALIEVA

122

OR-123 Purification of Bioactive Fractionations of Industrial Importance from Citrus reticulata Blanco Waste Peel Muhammad Asif HANIF, Rabia IDREES

123

OR-124 (Oligo)Alkylation of Toluene With Alpha-Olefins in the Presence of Ionic Liquids Khayala SEIDOVA, Akif AZIZOV, Reyhan ALIYEVA, Igrar NAZAROV, Aygun ABDULLAYEVA

124

xi

OR-125 Polyvinyl Pyrrolidone Coated Iron Oxide Nanoparticles as Contrast Agents for Magnetic Resonance Imaging (MRI) Muhammad Irfan MAJEED

125

OR-126 Complex Catalytic Systems on Based of Zirconium Phenolates Containing Amino Hydrochloride Substituents for Oligomerization of the Ethylene A.A. KHANMETOV, M.J. KHAMIYEV, A.H. AZIZOV

126

OR-127 Controlled Radical Polymerization of Some Acrilyc Monomers I.M.GULIYEVA

127

OR-128 Synthesis, Antimicrobial Activity of New 2- Thioxanthine and Dipyrimidopyridine Derivatives Samar EL-KALYOUBI, Fatmah AGILI, Shaker YOUSSIF

128

OR-129 Chemical Synthesis of 3,6-bis-(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-9-(4-vinylbenzyl)-9H-carbazole and Polymer Formation Used as Supercapacitor Electrode Material* Nesimi ULUDAG, Murat ATES

129

OR-130 Chemical Aspects of the Design Topological Insulators Based on the Metal Chalcogenides BabanlyM.B., ChulkovE.V.,Aliev Z.S., Amiraslanov I.R.

130

POSTER PRESENTATIONS

131

PO-1 New and Efficient Synthesis of Brominated Diazanaphthalene Derivatives: Key Compounds for Strongly Biologicaly Active Derivatives Sefa UÇAR, Arif DAŞTAN, Erdin DALKILIÇ, Selçuk EŞSİZ

132

PO-2 Effect of Filler Particle Size on Ionizing Electromagnetic Radiation Shielding Performances of Natural Mineral-Polymer Composite Ezgi Eren BELGIN, Gül Asiye AYÇIK, Ayşe KALEMTAŞ

133

PO-3 Synthesis and Characterization of Thermal Energy Storage Properties of Polystyrene/(Nonadecane-Octacosane) Micro-Nano Capsules Ahmet SARI, Alper BİÇER, Cemil ALKAN, Çınar KIZIL

134

PO-4 Preperation and Characterization of Magnetic Featured Horseradish Peroxidase Hybrid Nanoflowers Nalan ÖZDEMİR, İsmail ÖÇSOY, İsmail YILMAZ

135

PO-5 M/SiO2 (M= Co, Fe, Ru) Type Materials: Synthesis and Catalytic Activities for Hydrogenation of Ketones Nilgun KALAYCIOGLU OZPOZAN, Serkan DAYAN, Sevgi OZTURK

136

PO-6 Synthesis and Some Reactions of 4-(4-methylbenzoyl)-3-(4-methylphenyl)-1-pyridin-2-yl-1H-pyrazole-5-carboxylic Acid Elif KORKUSUZ, İsmail YILDIRIM

137

PO-7 Synthesis of Ruthenium(0) Stabilized by N-Donor Ligand: Using as Dye In the Dye-Sensitized Solar Cell (DSSC) Serkan DAYAN, Nilgun KALAYCIOGLU OZPOZAN

138

PO-8 Magnetic Phosphorus-Containing Polymer for Fast and Selective Solid Phase Extraction of Trace Amounts of Cd(II) and Pb(II) E. YILMAZ, R. M. ALOSMANOV, M. SOYLAK

139

http://pubs.rsc.org/en/results?searchtext=Author%3AE.%20Yilmaz

http://pubs.rsc.org/en/results?searchtext=Author%3AR.%20M.%20Alosmanov

http://pubs.rsc.org/en/results?searchtext=Author%3AM.%20Soylak

xii

PO-9 Dispersive Liquid-Liquid Micro Extraction of Lead(II) for Preconcentration and Separation in Environmental Samples Mustafa SOYLAK, M. Karaca

140

PO-10 A DFT (Density Fuctional Theory) On Sabinene and Isoabienol (the Essential Oils of Juniperus Communis) Faik GÖKALP

141

PO-11 A DFT Study of Bromoquinolines. Comparison of Experimantal and Theoretical Bioactivities of Bromoquinolines Salih ÖKTEN, Faik GÖKALP

142

PO-12 The Structural, Elastic and Electronik Properties of Pd2VAl Compound in Heusler Structure Osman ÖRNEK, S. DEMİR, Nihat ARIKAN

143

PO-13 The First-Principles Study on LuSe Compound in CsCl Structure Nihat ARIKAN, Osman ÖRNEK, Şule UĞUR, Gökay UĞUR

144

PO-14 Synthesis and in Vitro Antioxidant Properties of New 1-acetyl-3,4-disubstitue-4,5-dihydro-1H-1,2,4-triazol-5-ones Özlem GÜRSOY KOL, Haydar YÜKSEK

145

PO-15 Preparation, Characterization and Antimicrobial Activities of Some New Di-[2-(3-alkyl/aryl-4,5-dihydro-1H-1,2,4-Triazol-5-One-4-Yl)-azomethin-6-ethoxyphenyl] isophtalate Derivatives Haydar YÜKSEK, Faruk KARDAŞ, Önder ALBAYRAK, Muzaffer ALKAN,Fevzi AYTEMİZ

146

PO-16 Synthesis, Spectroscopic and Fluorescence Properties of N,N'-diethylnicotinamide Adducts of 2-bromobenzoates Co(II) and Ni(II) F. Elif ÖZBEK, Mustafa YÜKSEK, Hacali NECEFOĞLU

147

PO-17 A Review on Crystal Structures of N,N'-diethylnicotinamide Complexes of Metal Arylcarboxylates Hacali NECEFOĞLU, F. Elif ÖZBEK,Mustafa SERTÇELIK

148

PO-18 The Effect of Boron Compounds on the Levels of L- Carnitine, Leptin, IGF-I and HSP70 in Rat Fed with High-Fat Diet Onur ATAKİŞİ,Kezban YILDIZ DALGINLI,Emine ATAKİŞİ, Ruya KAYA, Canan GÜLMEZ

149

PO-19 Determination of pKa Values of Some 3-Alkyl(Aryl)-4-[3-(2-Methylbenzoxy)-Benzylidenamino]-4,5-Dihydro-1h-1,2,4-Triazol-5-Ones in Non-Aqueus Solvents Songül ULUFER, Özlem GÜRSOY KOL

150

PO-20 Synthesis and Antimicrobial Properties of Some Novel 3-alkyl(aryl)-4-[3-(3-nitrobenzoxy)-4-methoxybenzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones Fevzi AYTEMİZ, Haydar YÜKSEK, Önder ALBAYRAK, Muzaffer ALKAN

151

PO-21 Antioxidant Activities of Some 3-Alkyl(Aryl)-4-(3-Cinnamoyloxy-4-Methoxybenzylidenamino)-4,5-Dihydro-1H-1,2,4-Triazol-5-Ones with Their Acidic Properties Feyzi Sinan TOKALI, Haydar YÜKSEK, Fevzi AYTEMIZ

152

PO-22 Spectroscopic Properties of 3-Methyl-4-(4-isopropylbenzylidenamino)-4,5-dihydro-1H-1,2,4-Triazol-5-one molecule Gül KOTAN, Haydar YÜKSEK

153

PO-23 Synthesis and Investigation of Antioxidant Activities of Novel 3-Alkyl(Aryl)-4-[2-(3-methoxybenzoxy)-benzylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-ones Hilal MEDETALİBEYOĞLU, Haydar YÜKSEK, Özlem GÜRSOY KOL

154

xiii

PO-24 A Study on Theoretical and Experimentical Spectroscopic Properties of 3-N-propyl-4-[3-(3,5-dinitrobenzoxy)-benzylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-one Molecule Savaş KARA, Özlem GÜRSOY KOL, Haydar YÜKSEK, Hilal MEDETALİBEYOĞLU

155

PO-25 Synthesis, Characterization and Antioxidant Activities of {Bis-4-[3-(Alkyl(Aril)-4,5- dihydro-1H-1,2,4-Triazol-5-On-4-yl)-azomethin]phenyl} biphenyl-4,4’disulfonates Murat BEYTUR, Haydar YÜKSEK,Özlem GÜRSOY-KOL

156

PO-26 Synthesis and Antioxidant Activities of N-acetyl Derivatives Having 4,5-dihydro-1H-1,2,4-triazol-5-one Ring Muzaffer POLAT, Haydar YÜKSEK,Murat BEYTUR, Özlem GÜRSOY-KOL, Zeynep ZAFER, Savaş KARA

157

PO-27 Synthesis and in-Vitro Antioxidant Evaluation of New 1-Acetyl-3-alkyl(aryl)-4-(3-methoxy-4-acetoxybenzylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-ones Sevda MANAP, Haydar YÜKSEK, Özlem GÜRSOY-KOL

158

PO-28 Synthesis and Acidic Properties of Some Novel 3-Alkyl(aryl)-4-[3-ethoxy-4-(2-methylbenzoxy)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones Bahar BANKOĞLU, Haydar YÜKSEK,Sevda MANAP

159

PO-29 GIAO NMR Calculations of 3-Ethyl-4-(3-benzensulfonyloxy-4-methoxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-one Özlem AKTAŞ YOKUŞ, Haydar YÜKSEK, Gül KOTAN

160

PO-30 Prophylactic Effect of Beta Carotene on the Diethylnitrosamine-Induced Oxidative Stress in Rabbit Onur ATAKİŞİ, Oğuz MERHAN, Emine ATAKİŞİ, Ayla ÖZCAN, Necati KAYA, Cem ÖZİÇ

161

PO-31 The Effect of Goji Berry Extract on Liver Enzyme Activity and Antioxidant System in Carbon Tetrachloride Toxicity Ayşe KANICI, Onur ATAKİŞİ, Nurgül ATMACA, Füsun TEMAMOĞULLARI,

Yeşim AYDIN, Yonca YILMAZ

162

PO-32 Synthesis and Non-Aqueus Medium Titrations of Some Novel 3-Alkyl(aryl)-4-[2-(2-furylcarbonyloxy)-3-methoxybenzylidenamino)]-4,5-dihydro-1H-1,2,4-triazol-5-ones Muzaffer Alkan, Haydar Yüksek, Abdurrahman Gürbüz

163

PO-33 Effect of Substrate Temperature on The Functional Properties of Vanadium Oxide Thin Films Grown by Spray Pyrolysis Method Mustafa SAĞLAM, Betül GÜZELDİR

164

PO-34 Chemical Effect on the Atomic and Molecular Cross Sections of Some Ce Compounds Near the K Edge Rıdvan DURAK, Ferdi AKMAN

165

PO-35 Magnetically Separable Graphene Oxide-Fe3O4 Nanocomposites for Photocatalytic Degradation of Methylene Blue Under UV Irradiation Tuba Ezgi TÜZEMEN, Kübra BİLMİŞOĞLU, Ayşe Merve ASLANDAŞ, Murat

KIRANŞAN, Kadem MERAL

166

PO-36 A Facile Synthesis of Fluorescent Carbon Dots from Blueberry and Their Performance in Fe3+ Detection Ayşe Merve ASLANDAŞ, Neslihan BALCI, Mustafa ARIK, Halis ŞAKIROĞLU,

Yavuz ONGANER, Kadem MERAL

167

PO-37 Effects of Metal Ions on Binding Constants of Coumarine 35 To BSA and DNA Tuğba BAYRAKTUTAN, Yavuz ONGANER

168

xiv

PO-38 The Effect of Organized Surfactant Media on Energy Transfer between Coumarin 120 and Safranine T Molecules Ebru BOZKURT, Kadem MERAL, Yavuz ONGANER

169

PO-39 Interactions between Fluorescein and Safranine T in PC Liposomes Ebru BOZKURT, Tuğba BAYRAKTUTAN, Murat ACAR, Mahmut TOPRAK

170

PO-40 Synthesis of Halo- and Aminocyclitols Containing Eight-Membered Ring Emine SALAMCI, Ufuk Nusret KARAVAİZOĞLU, Yunus ZOZİK

171

PO-41 Fabrication and Neutron Dose Rate Measurements of a Ni Based New Super Alloy İncluding W, Cr, and Cu Abdulhalik KARABULUT, Turgay KORKUT, Bünyamin AYGÜN

172

PO-42 Synthesis of 5-(5-Oxo-pyrrolidin-2-yloxymethyl)-furan-2-carbaldehyde Derivatives Nurhan KİSHALI, Özlem GÜNDOĞDU, Pınar AYDIN, Yunus KARA

173

PO-43 Synthesis of New Norbornanoid Chiral Compounds via Desymmetrızation of 1, 2-vinyl dibromides Ramazan KOÇAK, Arif DAŞTAN, Giuseppe BORSATO, Ottorino De LUCCHİ

174

PO-44 An Efficient Synthesis of Substituted Naphthalenes and Anthracenes Esra TURAN AKIN, Musa ERDOĞAN, Ramazan KOÇAK, Nurullah SARAÇOĞLU, Arif DAŞTAN

175

PO-45 A Regioselective Approach for Functionalization of Indolines/Indoles at the 5-Position Haydar KILIÇ, Berrak ERTUĞRUL, Farrokh LAFZI, Nurullah SARAÇOGLU

176

PO-46 Purification and Characterization of Glutathione S-Transferase fromLaurel Fruit (Prunus Laurucerasus L.) Research the Effects of Some Metal Ions on Enzyme Activity Fikret TÜRKAN, Neslihan BALCI, Halis ŞAKİROĞLU

177

PO-47 Molecular Dynamics Studies of the Carboxy Indanone and Tetraline Compounds by NMR Spectroscopy Cavit KAZAZ, Süleyman GÖKSU, Adem ERTÜRK, Barış ANIL,Akın

AKINCIOĞLU

178

PO-48 Effect of Cu and Al Additive on the Functional Properties of Vanadium Oxide Thin Films Grown by Spray Pyrolysis Method Betül GÜZELDİR, Mustafa SAĞLAM

179

PO-49 Interpretation of the Laterally Inhomogeneous Fecrnic/N-Gaas Contacts by Tung’s

Approach Bahattin ABAY

180

PO-50 Ascorbic Acid (Vitamin C): Important for Human Nutrition Physiology and Health, an Antioxidative & Anticarcinogenic Vitamin Bilgehan POLATOĞLU

181

PO-51 Investigation of The Inhibition Effect of Kiwifruit (Actinidia Deliciosa) Juice on Human Carbonic Anhydrase-II Metin BÜLBÜL, Gözde İMDAT

182

PO-52 Synthesis and Characterization of Novel Pyrazole, Thiazole, Thiadiazole and Oxadiazole Derivatives of 1-(3-nitrophenyl)-3-phenyl-1H-pyrazole-4-carbaldehyde Samet MERT, Rahmi KASIMOGULLARI

183

PO-53 Determination of Fatty Acid and Heavy Metal Amounts in the Muscle of a Freshwater Fish (Capoeta Antalyensis) Using Gas Chromatography and Atomic Absorption Spectroscopy Kazım UYSAL, Banu YALIM, Yılmaz EMRE, Özgür AKTAŞ, Gül Nihan ÖZTÜRK

184

xv

PO-54 Synthesis and Characterization of ZnO Nanostructures via Tartaric Acid Gel Method Mustafa TUNCER Seher ÇETİN, Hasan GÖÇMEZ

185

PO-55 Purification and Characterization of Glutathione S-Transferase from Laurel Fruit (Prunus Laurucerasus L.) Research the Effects Some Metal Ions on Enzyme Activity Fikret TÜRKAN, Neslihan BALCI, Halis ŞAKİROĞLU

186

PO-56 Synthesis of Some Benzamide Derivatives and Investigation of Their Crystal Structures Şükriye ÇAKMAK, Halil KÜTÜK, Mustafa ODABAŞOĞLU

187

PO-57 Synthesis of Some Pyrimidine Derivatives and Investigation of Their Molecular Structures and Spectroscopic Properties Şükriye ÇAKMAK, Halil KÜTÜK, Mustafa ODABAŞOĞLU

188

PO-58 Solid Phase Extraction of Tartrazine and Determination by UV-VIS Spectrophotometer Aslıhan KARATEPE, Nazan SAYAR

189

PO-59 Design, Synthesis and Anticancer Activity of Novel Acylthioureas with Pyrimidine Core İrfan KOCA, Muhammet ER, Mehmet GÜMÜŞ, Aykut ÖZGÜR, Yusuf TUTAR

190

PO-60 Efficient Synthesis of Potential Biactive Molecules: Pyrazole, Thiazole and Coumarine Hybrid Compounds Mehmet GÜMÜŞ, İrfan KOCA, Ali DİŞLİ

191

PO-61 Synthesis, Characterization and Adsorption Studies of Cationic Dye Adsorbent Masoomeh MEHRNIA, Oya BAL, Murat TORUN, Dilek ŞOLPAN

192

PO-62 Optimum Conditions for Chromatographic Seperation of N-Nitrosodiphenylamine from Its Intermediate Sinem DEMIR, Murat TORUN, Dilek ŞOLPAN

193

PO-63 Synthesis and Antimicrobial Evaluation of New 3-Alkyl(aryl)-4-[3-ethoxy-2-(4-methoxybenzoxy)-benzylidenamino]-4,5-dihidro-1H-1,2,4-triazol-5-ones Faruk KARDA, Haydar YÜKSEK, Özlem GÜRSOY-KOL, Önder ALBAYRAK, Muzaffer ALKAN

194

PO-64 Contents and Distributions of Iron Fractions in Bafra, Çarşamba and Suluova Soils and Relationships with Some Soil Properties Havva Sera ŞENDEMİRCİ,Güney AKINOĞLUAhmet KORKMAZ, Ayhan HORUZ, Abdulkadir SÜRÜCÜ

195

PO-65 Synthesis of Bromo Substituted Indenoquinoline-Amin Derivetives Makbule EKİZ, Ahmet TUTAR, Yadigar ADİLOĞLU

196

PO-66 Improved Synthesis and Naked –Eye Ag+ Chemosensing Properties of 2,9- Dichloro-1,10-phenonthroline Said NADEEM, Mehmet Ali ÖZLER, Muhammad Raza SHAH

197

PO-67 Antioxidant and Cytotoxic Activity of Ganoderma Resinaceum Boud. Mehmet Emin DURU, Selçuk KÜÇÜKAYDIN, Aziz TÜRKOĞLU, Gülsen TEL,

Mehmet ÖZTÜRK

198

PO-68 Fumigant Toxicity of Essential Oil of Coridathymus Capitatus Against Adults of The Lesser Grain Borer, Rhizopertha Dominica (Coleoptera: Bostrichidae) Fabricius. Selçuk KÜÇÜKAYDIN, Mehmet Emin DURU, Memiş KESDEK, Gülsen TEL,

Mehmet ÖZTÜRK.

199

PO-69 Anticancer and Antioxidant Activity of Porodaedalea Pini (Brot.) Murrill Ebru DEVECİ, Gülsen TEL ÇAYAN, Mehmet ÖZTÜRK, Selçuk KÜÇÜKAYDIN, Mehmet Emin DURU

200

xvi

PO-70 The Chemical Composition of Essential Oil and Anticholinesterase Inhibition Activity of Various Extracts of Thymus Cilicicus Boiss. & Bal. Selçuk KÜÇÜKAYDIN, Mehmet Emin DURU, Erhan KAPLANER Gülsen TEL, Meltem TAŞ, Gülay ŞAVKINCI

201

PO-71 Acetazolamide Derivative Novel Acridindione Compounds as Carbonic Anhydrase Inhibitors Ramazan ULUS, Burak ADAY, Muharrem KAYA

202

PO-72 Efficient Synthesis of Tetrazole Derivatives Catalyzed by Recyclable Platinum Nanoparticles as Heterogeneous Catalyst under the Microwave Irradiation EsmaERKEN, İbrahim ESİRDEN,MuharremKAYA,FatihŞEN

203

PO-73 Synthesis of 5-Amino-1,3,4-Thiadiazole-2-sulfonamide Based Novel Acridindione Compounds Burak ADAY, Ramazan ULUS, Muharrem KAYA

204

PO-74 Highly Dispersed Platinum Nanoparticles Supported with Graphene Oxide for the One-Pot Synthesis of Acridinedione Derivatives Burak ADAY, Handan PAMUK, Fatih ŞEN, Muharrem KAYA

205

PO-75 One-Pot, Facile, Highly Efficient, and Clean Synthesis of Acridinedione Derivatives Using Vitamin B1 as a Catalyst Burak ADAY, Ramazan ULUS, Ahmet IŞIK, Muharrem KAYA

206

PO-76 Synthesis of Thioxanthone Based Water Soluble Copolymeric Macrophotoinitiator and Its Use in Photoinduced Free Radical Polymerization Meral AYDIN, Nüket ÖCAL, Nergis ARSU

207

PO-77 Ultrasound-Promoted Synthesis of Tetrahydropyridine Derivatives in Presence of M(OTf)X

Zühal TURGUT, Emel PELIT, Oğuz Rıdvan DÜRÜST

208

PO-78 Three- Component, One-Pot Synthesis Of Indeno[1,2-B]quinoline-7-one Derivatives Catalyzed by Triflat Zühal TURGUT, Özlem ELMAS, Kadir TURHAN

209

PO-79 Biological Activities of Flowers and Peel Oils of Citrus Aurantium L. Growing in Turkey Seda Güreli FERIDUN, Selçuk ALTUN, Ayşe OGAN, Ümit SALAN

210

PO-80 Investigation of Mechanical Properties of Nonwoven Felt- Polypropylene-Pumice Composite Materials Yalçın BOZTOPRAK, Sabih OVALI, Mahmut KAYAR, Yeşim Müge ŞAHİN

211

PO-81 Synthesis and Characterization of Novel Metallophthalocyanines Esra KAKI, Nurcan GÖGSU, Bekir SALİH, Özer BEKAROĞLU

212

PO-82 Investigation of Sound Permeability of Nonwoven Felt- Polypropylene-Pumice Composite Materials Yalçın BOZTOPRAK, Sabih OVALI, Mahmut KAYAR, Yeşim Müge ŞAHİN

213

PO-83 UV Curable Polyurethane Coating Materials Based Siloxane and Investigation of Their Thermal Properties Mert ÇINAR,Sevim KARATAŞ

214

PO-84 Synthesis and Characterization of UV Curable Waterborne Polyurethanes Tülin GACAL, Gökhan TOPÇU, Sevim KARATAŞ

215

PO-85 Synthesis and Characterization of Novel Pyridone Derivative Phthalocyanines Şaziye ABDURRAHMANOĞLU, Büşra MIZRAK

216

PO-86 Synthesis and Characterization of Novel A Structure Co(II) Phthalocyanine Şaziye ABDURRAHMANOĞLU, Büşra MIZRAK

217

xvii

PO-87 Determination of Trace Metals on Some Mushroom Species by ICP-OES After Microwave Digestion Method

Muhammet Emre HIŞIR, Esra ALTINTIĞ, Hüseyin ALTUNDAĞ

218

PO-88 Characterization of Nano Silver Particles Which Are Bonded With Sol- Gel Method to Activated Carbon

Esra ALTINTIĞ, Omer Faruk SOYDAN, Sule KIRKIL, Huseyin ALTUNDAĞ

219

PO-89 Derivative Spectrophotometric Determination of Ascorbic Acid and N-Acetylcysteine Merve AYHAN, Aysel KÜÇÜK TUNCA

220

PO-90 Total Phenolics, Total Flavonoids and Cupric Ion Reducing Antioxidant Capacity of Broad-Leaf Dock (Rumex Obtusifolius) Plant Esma Hande ALICI, Gülnur ARABACI

221

PO-91 Enzymatic Bio-Bleaching of Cotton/PA Fabric Ayşe USLUOĞLU, Gülnur ARABACI

222

PO-92 Anionic Dye Removal Using Polymer Inclusion Membrane (PIMs) Özlem DEMİRBAŞ, Havva POLAT, Yasemin YILDIZ, Murat TEKER,Aynur MANZAK

223

PO-93 Application of Polymer Inclusion Membranes (PIMs) Including Aliquate 336 for The Extraction of Humic Acid Cem KURŞUN,Yasemin YILDIZ,Aynur MANZAK,Abdil ÖZDEMİR,Ahmet TUTAR

224

PO-94 Speciation of Heavy Metals in Food Samples by Ultrasonic Supported Sequential Extraction Method and Microwave Leaching in Using ICP-OES Hüseyin ALTUNDAĞ, Muhammet YILMAZ, Asude ATEŞ

225

PO-95 Synthesis, Characterization, Photophysical and Electrochemical Properties of 4,4-Fluoro-8-ethyl-3,5-Bis(4'-ethylphenyl)-4-bora-3a,4a-diaza-s-indancene (BODIPY) Raşit Fikret YILMAZ, İbrahim Halil BAYDİLEK, Ömer Faruk TUTAR, Yavuz DERİN, Ahmet TUTAR

226

PO-96 Synthesis, Characterization, Photophysical and Electrochemical Properties of 4,4-Fluoro-8-(4'-bromophenyl-3,5-Bis(4'-trifluoromethoxyphenyl)-4-bora-3a,4a-diaza-s-indancene (BODIPY) Raşit Fikret YILMAZ, İbrahim Halil BAYDİLEK, Ömer Faruk TUTAR, Salih

ÖKTEN, Ahmet TUTAR

227

PO-97 A Facile and Efficient Synthesis of 5-Bromo-2,2-Dihydroxy-1,3-indandione (5-bromoninhydrin) from indane Raşit Fikret YILMAZ, İbrahim Halil BAYDİLEK, Ömer Faruk TUTAR, Ahmet

TUTAR

228

PO-98 Synthesis and Antimicrobial Activities of New Conazole and Fluoroquinolones Neslihan DEMİRBAŞ, Serap BAŞOĞLU, Yıldız UYGUN, Arif MERMER, Ahmet

DEMIRBAŞ, Serpil DEMİRCİ, Şule CEYLAN

229

PO-99 Synthesise of Isoxazole and Dehydroisoxazole from Chalcones Nurettin YAYLI, Seda FANDAKLI, Büşra YAYLI

230

PO-100 Synthesis and Antimicrobial Activity of Triazole Containing Azole Derivates Arif MERMER, Yıldız UYGUN, Serpil DEMİRCİ, Serap BAŞOĞLU, Ahmet DEMİRBAŞ, Neslihan DEMİRBAŞ, Serdar ÜLKER

231

PO-101 Synthesis and Characterization of New Triazole-Substituted Coumarin Derivatives Nurhan GÜMRÜKÇÜOĞLU

232

xviii

PO-102 Synthesis and Characterization of Novel Heterocyclic Compounds by Reacting Bis Coumarins and Triazole Derivatives Nurhan GÜMRÜKÇÜOĞLU

233

PO-103 Synthesis of New Triazol Derivatives Containing Several Pharmacophore Groups and Investigation of Their Antimicrobial Activities Ahmet DEMİRBAŞ, Yıldız UYGUN, Serap BAŞOĞLU, Arif MERMER, Hacer BAYRAK, Şule CEYLAN, Neslihan DEMİRBAŞ

234

PO-104 Synthesis and Characterization of Some New Conazole Derived from Ethylpiperazine Nucleus Serap BAŞOĞLU, Yıldız UYGUN, Hacer BAYRAK, Neslihan DEMİRBAŞ, Arif MERMER, Ahmet DEMIRBAŞ, Şule CEYLAN

235

PO-105 Synthesis and Antimicrobial Activity Evaluation of New Fluoroquinolone Derivatives Starting from Triptamine Yıldız UYGUN, Serap BAŞOĞLU, Arif MERMER, Hacer BAYRAK, Sule CEYLAN, Ahmet DEMİRBAŞ, Neslian DEMİRBAŞ, Serdar ÜLKER

236

PO-106 Synthesis and Antimicrobial Activities of Novel Conazoles with Triazol Ring Arif MERMER,Yıldız UYGUN, Serpil DEMİRCİ, Serap BASOGLU, Neslihan DEMİRBAŞ, Serdar ÜLKER

237

PO-107 Supercapacitor Device Preparation and Equivalent Circuit Model Evaluation of Poly(3,6-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-9-tosyl-9H-carbazole)/Carbon Nanotube as an Active Material Nesimi ULUDAĞ, Murat ATEŞ

238

PO-108 Concise Total Synthesis of 20-diethyl-4-dimethyldasycarpidone Nesimi ULUDAĞ, Medet YAKUP

239

PO-109 Supercapacitor Study of Poly(2-(3,6-bis(-(2,3-dihydrothieno[3,4-B][1,4]dioxin-5-yl)-9h-carbazole-9-yl)ethyl methacrylate)/CarbonNanotube Composite Material Murat ATES,Nesimi ULUDAĞ

240

PO-110 Synthesis of Mid-Chain Functional Macrophotoinitiators of Poly(D,L-Lactide)-Based Polymers by Rop and Their Use in Photoinitiated Polymerization Mustafa DEĞİRMENCİ,Mustafa DURGUN, Esra BARIM

241

PO-111 Synthesis, Characterization, Catalytic and Cytotoxic Activities of A Novel Pyridyloxycyclophosphazene Ligand and Its Ru(II) Complex Zafer UYAR, Diğdem ERDENER ÇIRALI, İsmail KOYUNCU

242

PO-112 Investigation of Properties of Water Soluble 1-[2-(dimethylamino)ethyl]-1H-Tetrazole Substituted Metal-Free and Zinc(II) Monophthalocyanines Ebru YABAŞ, Esra BAĞDA

243

PO-113 Synthesis and Spectral Charaterization of 4-Nitro-2-(5-chloro/methy-1,3-benzoxazol-2-yl)phenols Demet GÜRBÜZ, Adem ÇINARLI, Aydın TAVMAN, Süleyman TANYOLAÇ

244

PO-114 Synthesis and Spectral Characterization of 1,3-Bis(1H-benzimidazol-2-yl)-2-oxapropane Complexes with Various Zn(II) Salts Aydın TAVMAN, Adem ÇINARLI

245

PO-115 The Synthesis and Characterization of Some New S-, S,S- and N,S-Substituted Nitrobutadienes F. Serpil GÖKSEL, Elif AYDIN

246

PO-116 Synthesis of New N-, Substituted 1,4-Benzoquinone Compounds and Their Thio Substituted Derivatives Hakan BAHAR, Sibel ŞAHİNLER AYLA, Funda ÖZKÖK, Cemil İBİŞ

247

xix

PO-117 Synthesis and Spectroscopic Characterization of Novel N- and N,S-Substituted Naphthoquinone Compounds Sibel ŞAHİNLER AYLA, Hakan BAHAR, Cemil İBİŞ

248

PO-118 Synthesis and Spectral Characterization of 5-Chloro-2-(5-chloro/methyl-1,3-benzoxazol-2-yl)phenols Demet GÜRBÜZ, Adem ÇINARLI, Aydın TAVMAN

249

PO-119 Determination of Phenolic Acids in Concentrated and Non-Concentrated Apple Juice Made from Denizli by High-Performance Liquid Chromatography DAD Mürüvvet KARAKAPLAN , Mustafa ÖZCAN

250

PO-120 Hydrogen Generation from Sodium Borohydride Hydrolysis Using Co-B Catalyst on Supported Sepiolite Seda EROL, Mine ÖZDEMİR

251

PO-121 Adsorption Thermodynamic Parameters of SBA15 and B-SBA-15 Mesoporous Materials by Using Inverse Gas Chromatography Technique Alime ÇITAK, Tuğba CANDAŞ

252

PO-122 The Synthesis and Characterization of New Oxime Ligands and Their Complexes with Cu(II) Metals Tufan TOPAL, Emin KARAPINAR

253

PO-123 Characterization of Natural Organic Matter (NOM) by Resin Adsoprtion Method in Drinking Waters Tufan TOPAL, Nazan KARAPINAR, Vedat UYAK

254

PO-124 Antioxidant Properties of Novel Mixed Ligand Complexes Obtained from Saccharinato Complexes and Azo Dye Ligand (mnppa) Nevin TURAN, Ragıp ADIGÜZEL, Kenan BULDURUN, Ercan BURSAL

255

PO-125 Synthesis and Catalytic Activity Studies of Ru Complexes Bearing 2-(1H-benzimidazol-2-yl)quinoline Derivatives Melek TERCAN, Osman DAYAN, Namık ÖZDEMIR

256

PO-126 Separation, Optimization and Quantitative Determination of Fruit Acids by New Mixed-Model Column in HPLC Uyan YÜKSEL, Hayriye ARAL, K.Serdar ÇELİK

257

PO-127 Quantitative Determination of Phenolic Compounds in Mushroom by New Mixed-Model Column in HPLC K.Serdar ÇELİK, Hayriye ARAL, Uyan YÜKSEL

258

PO-128 Chemical Compositions of Fatty Acid Obtained from Seeds of Silybum Marianum L. Gaertn (Thistle) by Using Cold Press Eyyüp KARAOĞUL, M. Hakkı ALMA, Ömer ÇİÇEK, Ertuğrul ALTUNTAŞ

259

PO-129 Synthesis and Characterization of Methyl Cellulose Obtained from Cotton Waste: Application in Cement Paste Ali KOÇ, Sümeyye AKARSU, C. Ayhan ZIBA, Mustafa DOLAZ

260

PO-130 Anti-Microbial Activity of Volatile Oils Extracted from Citrus Aurantifolia L. on Several Microorganisms Muharam Yaseen MOHAMMED, Tufan SALAN, Eyyüp KARAOĞUL, M. Hakkı

ALMA

261

PO-131 Determination of Cobalt with Cloud Point Extraction Ümit DİVRİKLİ, Mustafa SOYLAK, Latif ELÇİ

262

PO-132 Synthesis and Characterization of Imine Polymers Containing Methyl Silane Group İsmet KAYA, Neşe ÇITAKOĞLU

263

xx

PO-133 Study of Thermal Degradation Kinetic of 7-Amino-4-Hydroxynaphthalene-2-Sulfonic Acid Fatih DOĞAN, Kevser TEMİZKAN, İsmet KAYA

264

PO-134 Chemical Characterization of Humic Substances Added Wood Plastic Composites Nasir NARLIOGLU, Eyyup KARAOĞUL, M. Hakki ALMA

265

PO-135 GC/MS Analysis of Essentıal Oil of Salvia Frutıcosa M. and Sideritis Perfoliata L. Ertuğrul ALTUNTAŞ, Eyyüp KARAOĞUL, BETÜL ÇELİK, M. Hakkı ALMA

266

PO-136 Synthesis of Oil-Based Graft Copolymers via the Combination of Ring Opening Polymerization and Free Radical Polymerization Abdulkadir ALLI, Yurdagül ARI, Sema ALLI, Muharrem GÖKÇEN

267

PO-137 The Effects of Transplant Age on Element Content Determined by Wavelength-Dispersive X-Ray Fluorescence Spectrometry of Broccoli (Brassica Oleracea L. Var. İtalica) Cultivars Faika YARALI, HalukÇağlar KAYMAK, İsmail GÜVENÇ, Ali GÜROL

268

PO-138 Synthesis and Characterization of Pyrimidine-Containing Schiff Base Derived from O-Vanillin and Its Metal Complexes Mehmet Emin HACIYUSUFOĞLU, Mehmet SÖNMEZ, Benan KILBAŞ, Zülbiye ÖNAL

269

PO-139 Synthesis of Some Heterofunctionalized Penicillanic Acid, Norfloxacine and Ciprofloxacine Derivatives and Investigation of Their Biological Activities Serpil DEMİRCİ, Meltem YOLAL, Arif MERMER, Neslihan DEMİRBAŞ, Ahmet DEMİRBAŞ

270

PO-140 A Simple and Sensitive Colorimetric and ‘‘Turn-On’’ Fluorometric Sensor for Arsenic

Species in Aqueous Media EsraŞEN, SerdarATILGAN

271

PO-141 AIE Active Tetraphenylethene: Rapid and Selective Fluorescent “Turn-On” Sensor for

Fluoride Ion in Aqueous Media Mine BİNECİ, SerdarATILGAN

272

PO-142 Synthesis of 2-(2-Chlorophenyl/ 3,4-dichlorophenyl)-5-methyl-1,3-benzoxazole Compounds Adem ÇINARLI, Duygu ÖZATA, Demet GÜRBÜZ

273

PO-143 Metal Oxide Nanoparticles: An Effective Heterogenous, Recyclable Catalyst for Synthesis of Thio Schiff Bases Aslıhan DALMAZ,Mesut ÖZDİNÇER, Elif AYDINLI, Sefa DURMUŞ

274

PO-144 Comparative Studies on Conventional & Microwave Synthesis of 2-Aryl Benzothiazoles and Their Antibacterial Activities Aslıhan DALMAZ,Mesut ÖZDİNÇER, Elif AYDINLI, Sefa DURMUŞ

275

PO-145 Synthesis and Characterization of Pyrimidine-Containing Schiff Base Derived from O-Vanillin and Its Metal Complexes Mehmet Emin HACIYUSUFOGLU, Mehmet SÖNMEZ, Benan KILBAŞ, Zülbiye ÖNAL

276

PO-146 Synthesis, Characterizational Electrochemical Study A New Heterocyclic Schiff Base and Its Metal Complexes [Co(II), Ni(II), Cu(II), Pd(II)] Mehmet Emin HACIYUSUFOGLU, Mehmet SÖNMEZ, Benan KILBAŞ,

Abdulkadir LEVENT

277

PO-147 Preparation of The Micronize Materials for The Water-Based Paint Esvet AKBAŞ, Aziz SÖKMEN

278

xxi

PO-148 Antimicrobial Agents In Textile Industry Aslı DEMİR, Tülay GÜLÜMSER, Esen ÖZDOĞAN

279

PO-149 Methods Used for The Surface Modification of Textiles EsenÖZDOĞAN, AslıDEMİR, TülayGÜLÜMSER,

280

PO-150 Reusebility of the Laccase Incorporated Nanofiber Based Biocomposite Generation with and without Cyclodextrin Addition Hasan Basri SAVAŞ, Mehmet Fatih CANBOLAT, Fatih GÜLTEKİN

281

PO-151 Experimental Application of Kefir and Acetylsalicylic Acid on Antioxidant Activity in Rats BetülMermiCEYHAN, Hasan BasriSAVAŞ, Altuğ ŞENOL, GürselACARTÜRK

282

PO-152 Electrochemical Synthesis and Electrochromic Application of A Novel Polymer Based on Carbazole Aysel AydınKOCAEREN

283

PO-153 Effıciency of Wet and Dry Digestion for Determination of Selected Metals from Coal by FAAS Tidža Muhić ŠARACA, Sadber KASAPOVIĆA, Dejana BRKIĆB

284

PO-154 Synthesis of Nanostructured Metal - Containing Catalysts and Their Use at Refining of Heavy Oil Residues V.M. ABBASOV, H.J. IBRAHIMOV,G.S.MUKHTAROVA, N.Kh.EFENDIYAVA, R.I.HUSEYNOVA

285

PO-155 Ionic Liquids on The Basis of Formic Acid and Amines For Selective Purification of Naphthalane Oil V.M. ABBASOV, L.I. ALIYEVA, P.A. MOVSUMOVA, A.E. ALIZADE

286

PO-156 Investigation of Liquid-Phase Oxidation of Naphthene-Paraffinic Hydrocarbons of Azerbaijan Oils V.M. ABBASOV, L.M. AFANDIYEVA, L.I. ALIYEVA, L.H. NURIYEV, Ch.Q. SALMANOVA, S. F. AHMADBAYOVA, F.N. SEYIDAHMADOVA

287

PO-157 Investigation of Inhibitory Properties of Salts and Complexes of N- Diethylamine Amides of Oleic Acid of CO2-corrosion V.M. ABBASOV, N.Sh., RZAYEVA S.A. SULEYMANOVA, A.H. TALYBOV

288

PO-158 Effect Pigments in Multicoatings on Textiles Boris MAHLTIG, Linfei WU,Jieyang ZHANG, Hajo HAASE

289

PO-159 Demonstration in Teaching Chemistry: the Case of Two High-Schools from Sarajevo Canton Meliha Zejnilagić-HAJRIĆ, Ines NUIĆ

290

PO-160 Synthesis and Properties of Oligomers of 4-Aminophenol Rena AHMEDOVA, Dilbar ALIYEVA, Bakhtiyar MAMMADOV

291

PO-161 New Ecologically Water-Diluting Epoxide Telomers Almaz CHALABIYEVA, Nelli ISHENKO

292

PO-162 Local Catalysts: Synthesis and Application N.Ben TAHAR , H.MIMOUN

293

PO-163 An Efficient Synthesis, Characterization and Anti-Inflammatory of Functionalized Triazoles and Tetrazoles via 1, 3-Dipolar Cycloaddition of 2-Azido-1-(8-hydroxyquinolin-5-yl)ethanone Shawkat ABD-ELMOHSEN

294

PO-164 Improvement of Operational Properties of Combustive-Lubricating Materials by Using Esters of Vicinal Dicarboxylic Acids Maharram Ali MAMMADYAROV, FatmakhanymKheybarALIYEVA

295

xxii

PO-165 Synthesis A Number of Some New Dihydrazones Compounds by Microwave Method Ebtihal Qahtan ABDULLAH, Abdullah Saleem KHAZAL, Amal Qahtan ABDULLAH Chemistry Department , College of Science , Tikrit University,Iraq

296

PO-166 Superabsorbent Eco-Friendly Cellulose Based Hydrogel as Controlled-Urea Release Packing System Saber IBRAHİM, Maha SULTAN, Zenat A. NAGİEB, Galal A.M. NAWWAR Packaging department, National Research Centre, Elbehoth Street 33, 12622, Dokki, Cairo, Egypt.

297

PO-167 New Cycloalkyl-Phenol Based Antioxidant for M-8 Engine Oil Çalışkan Mehmet METE , Mirzayev VAGIF , Bağırzade RANA , Mammadov FAHREDDIN , Rasulov ÇINGIZ ANAS

298

PO-168 Synthesis and Biological Evaluation of Some Benzimidazoles Derivatives. Lamouri HAMMAL, Saliha MEKSEM, Bellara NEDJAR-KOLLI.

299

PO-169 Determination of Free Amino Acids in Mushrooms from Bosnia Using TLC and Spectophotometric Method Aida ŠAPČANIN, Mirsada SALIHOVIĆ, Amra ALISPAHIĆ, Alema DEDIĆ,

Emina RAMIĆ, Ekrem PEHLIĆ

300

PO-170 Qualitative and Quantative Determination of Different Pesticides in Playground Soils of Sarajevo Aida ŠAPČANIN, Mirsada Čakal, Mirsada SALIHOVIĆ, Ekrem PEHLIĆ

301

PO-171 Comparison Study between Crude Alkaloid Extracts from Baobab (Adansonia Digitata) Leaves and Some Anti-Malarıa and Antibiotics Abiona Dupe LYDİA, Olaoye Fatimo OLUBUKOLA, Bakare ADETUTU

302

PO-172 Bezylidene: Synthesis and Reactivity KhaledMESBAH, SalahRHOUATI, Yulian. M VOLOVENKO, Zoya VOITENKO

303

PO-173 Synthesis of Macrocyclic Polyether’s Based on Alicyclic Dioximes R.N. BUDAGOVA,S.B. ZEYNALOV, N.A. ABDULLAYEVA

304

PO-174 Features of Phase formastion in the Tl5Te3(Tl2Te)-Tl9LnTe6-Tl9BVTe6 Systems Samira IMAMALIYEVA, Turan GASANLY, Fuad SADYGOV, Mahammad BABANLY

305

PO-175 Anti Tumoral Activity of Hydrazyl Pyrrolidine 2,5-Dione and 2-Thioxo Imidazolidine 4-one S. AichoucheBOUZROURA, L. SALHI, Boudjlida, S. BOUGUERRAAOUICHAT, B. NEDJARKOLLI

306

PO-176

New Approach Synthetic of 4-Thiazolidinones Scaffold. Evaluation of Antimıcrobial

Activity Rosa NECHAK,Samia A. BOUZROURA,Bellara N. KOLLI,YaminaBENMALEK,Lydia SALHI, Sophie P. MARTINI,Vincent MORIZUR,ElisabetDUNACH

307

PO-177 Thionation of β -Enaminones with Lawesson's Reagent: Synthesis of Pyranopyrazole Derivatives Houria LAKHDARI, Norah BENNAMANE, Brahim CHERFAOUI, Bellara NEDJAR-KOLLI

308

PO-178 Synthesis and Biological Evaluation of New imidazo[1,2-a]pyridine Derivatives Saléha BAKHTA, Larbi Arslane HAOUCHINE,Bellara NEDJAR-KOLLI

309

xxiii

PO-179 New Synthesis and Reactivity of 3-Acetoacetyl-2H-chromen-2-one, Based Condensed Heterocycles Soumaya Ben MOHAMED, Yahia RACHEDI, Maamar HAMDI, Françoise DUMAS,

310

PO-180 Synthesis and Antibacterial Activity of Some New Bis-1,3,4-Thiadiazole Derivatives Derived from Adipic Acid Mustafa Yawuz JAMAL

311

PO-181 Crystallization and Phase Transition of Solid Solutions Based on the AI8BIVX6 (AI-Cu,

Ag; BIV-Ge, Sn; X-S, Se)Compounds Yusif YUSIBOV, Isfendiyar ALVERDIYEV, Vusala ABBASOVA,Leyla MASHADIYEVA, Dilgam TAGIYEV, Mahammad BABANLY

312

PO-182 Phase Equilibria in the Systems Tl-X-I (X-S, Se, Te) and Thermodynamic Properties of Thallium Chalcogenide Iodides Dunya BABANLY, Akif ALIYEV, Dilgam TAGIYEV

313

PO-183 Contribution of the Chromatographic Step in the Uncertaınty of an HPLC Analytıcal

Procedure O. DJELLOULI, E. ROZET, H. BENSAOULA, B. DAHMANI, P. HUBERT

314

PO-184 Synthesis of Novel α -Aminoacids Bearing 1,2,4-Triazinone and Steroidal Moieties As Enzymatic Affects (Cellobaiase Activity) – Part II Dina Abed BAKHOTMAH

315

PO-185 Synthesis, Spectroscopic Analysis and Electrochemical Study of a New α-Aminophosphonic Acid. Saleh CHAFAA, Nadjib CHAFAI, Khalissa BENBOUGUERRA

316

PO-186 Using The Catalytic System Consisted of Seokar-600 and Its Mixture with Halloysite Nanotube for Thermocatalytic Conversion Heavy Gasoil and Its Mixture with Cotton Oil Tarana MAMMADOVA, Elmira ASGAROVA, Nadira HASANKHANOVA, N.V., NATAVAN, Narmin SAFAROVA

317

PO-187 New Catalytic Systemwith Halloysite Nanotube for Thermocatalytic Conversion Heavy Gasoil and Its Mixture with Cotton Oil Tarana MAMMADOVA, Elmira ASGAROVA, Nadira HASANKHANOVA, N.V., NATAVAN, Narmin SAFAROVA

318

PO-188 Processing of Pyrolysis Liquid Products with Using of New Catalytic Complex H.J.IBRAHIMOV, M.I.RUSTAMOV, Z.M.IBRAHIMOVA, K.M.GASIMOVA, R.H.AHMADOVA, I.V.KOLCHIKOVA

319

PO-189 Oxidative Dehydrogenation of Cyclohexanol to Cyclohexanone Over Modified Zeolite A.M. ALIYEV, M.G. ALIYEVA, Z.A. SHABANOVA, G.A. ALIZADE

320

PO-190 Studies of the Catalytic Activity of The Modified Zeolite in the Oxidative Dehydrogenation of Methylcyclohexane A.M. ALIEV, Z.A. SHABANOVA, A.I. KARIMOV, U.M. NAJAF-GULIYEV

321

PO-191 Chromatographic Separation of Enantiomers Acids Using Macrocyclic Abderrezak HAMDI, N.BOUCHAIR, M.RIGHEZZA

322

PO-192 Effective Method for Obtaining Methyl Ethyl Ketone Rena AĞAYEVA, Fuad AĞAYEV, Ağadadaş ALIYEV

323

PO-193 Metal-Containing Nanocomposites on the Basis of Isotactic Polypropylene Nushaba KURBANOVA, Nahida ALIMIRZOYEVA

324

PO-194 Synthesis of Self-extinction Polyesters on the Basis of Polybromobicyclic Dicarboxylic Acids Raisa ISMAYILOVA, Aga MUSTAFAYEV, Eldar RAMAZANOV

325

xxiv

PO-195 Study of Interactions Mixtures (Biodegradable Polymer / Active Ingredient) Obtained by Different Methods of Preparation Rebiha DAMICHE, Baitiche MILAD

326

PO-196 Selectivity of CDK1 and CDK2 Inhibitors by Heuristic Approach Aleksandar EFTIMOSKI, Mejra BEKTASEVIC, Elvisa HODZIC, Slavica ERIC, Halid MAKIC

327

PO-197 Diosgenin Bearing Heterocycles Fused to The A-Ring of The Steroid Nucleus Khaled SHAWAKFEH; Hussein AL-MUGHAID

328

PO-198 Hydroxyalkyl Derivatives of Diethyldithiocarbamic Acid as a Hardener For Polyethylene-Oligomer Compositions Valeh JAFAROV, Alverdi KERIMOV, Nadir ALEKPEROV, Arzu ORUJOVA

329

PO-199 Synthesis and Characterization of Perylene Derivatives for Liquid Crystal Display Black Matrix of Low Dielectric Constant Woosung LEE, Sim Bum YUK, Jae Pil KIM

330

PO-200 Modified Activated Carbon for the Removal of Cadmium(II) and Zinc(II) from Wastewater N. BOUCHENAFA-SAÏB, O.MOHAMMEDI, N. MADANI,B. HAMADA, O. CHERIFI.

331

PO-201 The Hydrogenation of p-Chloronitrobenzene Over Pd-M/C Catalysts N. BOUCHENAFA-SAIB, O.MOHAMMEDI, N. MADANI, B. HAMADA, O. CHERIFI.

332

PO-202 Reactivity of Quinoline Derivatives Khaled MESBAH, Salah RHOUATI

333

PO-204 A Novel Synthesis of 7,8-Dihydrocinnoline-5(6H)-ones by Cyclocondensation of Balis-Hillman Adducts of Arylglyoxals Bagher EFTEKHARI-SIS, Maryam ZIRAK

334

PO-205 Application of 5,6-Diphenyl-3-(pyridin-2-yl)-1,2,4-triazine as an Efficient Ligands in Pd-Catalyzed Heck Reaction Bagher EFTEKHARI-SIS, Maryam ZIRAK

335

PO-206 BiCl3-Catalyzed Three-Component Synthesis of 10-Aryl-7,8-dihydropyrano[3,2-b]chromene-4,9(6H,10H)-diones Maryam ZIRAK

336

PO-207 Selective Oxidation of Sulfides by a Novel İron(III) Complex Containing a N,O- Type Bidentate Oxazoline Ligand Mojtaba AMINI, Reza Masomi JAHANDIZI

337

PO-208 Novel Thiazoline -Copper and Palladium Complexes as Efficient Antibacterial Agents Reza Masomi JAHANDIZI,Mojtaba AMINI

338

PO-209 Preparation and Chracteristics of Hemostatic Nanofibrous Sheets Containing Blood Clotting Agents Eun Jung SIM, Sun Jong KIM, Eun Jin KIM, Insu BAEK, and Oh Hyeong KWON

339

PO-211 Cr-Substituted Ni-Zn Ferrites via Oxalate Decomposition, Structural, Electrical and Magnetic Properties M.A. GABAL , Y.M. AL ANGARI, F.A. AL-AGEL

340

PO-212 Nature of Steel Substrate Effect on Intermetallic Compounds of Coatings Obtained by Galvanization Younes BENARIOUA, Didier CHICOT

341

xxv

PO-213 Zn-Cr Co-Substitution Effect on the Structural and Magnetic Properties of Nano-Sized CuFe2O4 Synthesized via Oxalates Decomposition Route Mohamed Abdel Fattah GABAL

342

PO-214 Application of Multivariate Curve Resolution Alternating Least Squares (MCR-ALS) to The Quantitative Analysis of Food Colorants Using Spectrophotometric Acid-Base Titrations Masoumeh HASANI, Masoud SHARIATI-RAD, Elahe BIDAD

343

PO-215 Spectroscopic Study of Charge Transfer Complexation between Some Benzimidazole Drugs and Picric Acid Ohoud Hassan AL-MOHAMADY

344

PO-216 Development and Validation of a Stability˗Indicating RP- HPLC Method for Determination of Sofosbuvir in Bulk and Pharmaceutical Dosage Forms Tamer Awad ALI, Gehad G. MOHAMED, Ali A. AGLAN, Fakiha El-Taib HEAKAL

345

PO-217 Synthesis of New Stable Verdazyl Radical Ekaterina MARTYNKO, Pavel PETUNIN, Pavel POSTNIKOV, Marina TRUSOVA

346

PO-218 Synthesis, Radical Copolymerization of (P-vinylphenyl)cyclopropyl- Chlorocinnamate with Styrene and Photosensitivity of the Prepared Copolymers Kazim GULIYEV, Afat ALIYEVA, Dilbar NURULLAYEVA, Abasgulu GULIYEV

347

PO-219 New Polymer Compositions on The Basis of Mineral Fillers with Appreted Polyolefins Sevil BEKTASHI, Gulnara BABAYEVA, Gulnara MUSAYEVA,Valeh JAFAROV

348

PO-220 Cationic Polymerization of Vinylcyclopropyl Ethers and Photo-Structurization of the Prepared Polymers Rita SHAHNAZARLI, Abasgulu GULIYEV

349

PO-221 Numerical Study of Natural Convection Heat Transfer Performance in an Inclined Cavity: Nanofluid and Random Temperature Mohamed SI-AMEUR, Hicham SALHI, Nadjib CHAFAI

350

PO-222 Experimental, DFT Calculation, Biological Activity and Anion Sensing Applications Studies of a New Schiff Base (E)-4-[(pyridin-3-ylimino)methyl]benzene-1,3-diol Hüseyin ÜNVER, Bahadir BOYACİOGLU, Celal Tuğrul ZEYREK, Devrim YOLAL, Mustafa YILDIZ

351

PO-223 Reactivity of polybromine-cyclopentadienes and their ability to complexation A.M.Mustafayev, S.S.Kerimova

352

PO-224

Investigation of Relationship between Formation of Chemotype with Structuring of Humic Substances in the Forest; Case of Kefken (Kocaeli) Ali Gürel, Mehmet Özdemir, Mesut Tandoğan, Ömer Beyhan, İbrahim Halil Baydilek, Ahmet Tutar

353

ORAL PRESENTATIONS

2

OR-1 Sulphur-containing Antioxidants of Combined Action

Vagif M. FARZALIYEV

Institute of Chemistry of Additives of Azerbaijan National Academy of Sciences, Az 1029, Beyukshor Highway, Block 2062, Baku, Azerbaijan

[email protected]

Abstract:

Oxidation stability is one of the most important operational properties of lubricants inasmuch as a great many undesirable phenomena, taking place in engines and mechanisms in the process of their operation, are associated with formation of various oxidation products. Therefore the development of highly effective antioxidants is an actual problem of the chemistry of additives.

This report deals with the results of recent researches on the synthesis, study ofthe action mechanisms and also the interrelation between the structure and antioxidant efficiency of sulphur-containing derivatives of phenols (phenolsulphides), amines (aminosulphides) and other sulphur-containing organic compounds.

It has been established that the compounds mentioned are the antioxidants of combined action, i.e. they terminate the oxidation chain by reacting with peroxy radicals and decompose hydroperoxides.

The unique characteristics of the above antioxidants such as ability of the products of their oxidation by hydroperoxides to catalytically decompose hydroperoxides into the molecular products and cause multiple chain termination in the oxidizing hydrocarbons have been found out.

A supposition concerning the structures of oxidation products of some antioxidants, affecting the catalytic decomposition of hydroperoxides, has also been made.

The kinetic regularities and quantitative characteristics of the reactions of the above antioxidants with cumyl peroxide radicals and cumyl hydroperoxide, and also interrelation between their structure and activity in the reaction have been established.

Thus the studied sulphur-containing compounds are the antioxidants of combined action: terminate oxidation chains reacting with peroxide radicals;being oxidized by hydroperoxides form products which catalytically destruct hydroperoxides into molecular products and actively react with peroxide radicals.

In inhibiting the oxidation process of hydrocarbons by the antioxidants containing sulphur atom in combination with phenolic or aniline fragment an internal synergism (autosynergism) leading to new effects is observed.

mailto:[email protected]

3

OR-2 New Reactions of Acetylenes: An Unexpected Easy Full Cleavageof Polarized C≡C Moiety

under Action of N-Nucleophiles Sergey VASILEVSKYa, b, Maria DAVYDOVAa

aInstitute of Chemical Kinetics & Combustion, Novosibirsk, Siberian Branch of Russian Academy of Sciences, Novosibirsk. 630090, Russian Federation,

b Novosibirsk State University, 2 Pirogova Str., 630090, Novosibirsk, Russian Federation Abstract: The reaction of arylketoalkynes with 1,2-diaminoethane leads to the full scission of the triple bond with the formation of aryl methyl ketone and imidazoline fragments. Similar transformation occurs by interaction of arylketoalkynes with2-aminoethanoles leading to products of full cleavage of substrate: an aryl methyl ketone and corresponding an amide (N-(1-hydroxy-1-R3-2-R2-eth-2-yl)-N-R1-arylamide).In both transformations one of the alkyne carbons undergoes formal reduction with the formation of three C-H bonds, whereas the other carbon undergoes formal oxidation via the formation of three C-N bonds (one π and two σ). Computational analysis confirmed that the key fragmentation step proceeds via a six-membered TS in a concerted manner. Activation barriers, reaction energies, and the transition state geometries for fragmentation reaction were calculated and mechanisms for both reactions are suggested.

OHNH

N

OH

R3

R'

R1

+

O

R1

R2

R3

R2

O

R'

H2NNH2

+O

N

NH

R'

R, = Ar; R' = Alk, Ar, Het R1, R2, R3 = H, CH3, Ph

R

R

O

R

H2O

Scheme1. Products of full cleavage of reactionsofarylketoalkyneswithN-nucleophiles.

In summary, we have described new reactions of acetylenes - a cascade transformation that breaks all three C-C bonds in a polarized alkyne moiety under action of N-nucleophiles This work is supported by grant RFBR No. 10-03-00129-a (2013-2015),grant of the Ministry of Education and Science of the Russian Federation (2014-2016).

References

1. S. Roy, M.P. Davydova, R. Pal, K. Gilmore, G.A. Tolstikov, S.F. Vasilevsky, I. V. Alabugin,J. Org. Chem., 2011, 76, 7482–7490.

2. S.F. Vasilevsky, M.P.Davydova,D.N. Tomilin, L.N. Sobenina, V.I. Mamatuyk, and N.V. Pleshkova. ARKIVOC,2014, 132-144.

3. S. F. Vasilevsky, M. P.Davydova, I. V. Alabugin, Mend Comm.,2015 (in press).

4

OR-3 Synthesis and Crystal Structure of 4,5,12,13-Tetraaza-dibenzo[b,k]chrysene

Famil VALIYEV Department of Corrozion protection, “Oilgasscientificresearchproject”Institute, SOCAR, Baku,

Azerbaijan, AZ1012, [email protected] Polycyclic and heterocyclic aromatic hydrocarbons are used for active layer of n- and p-channel organic field-effect transistors (OFETs), because they can realize a high mobility. Nevertheless, instability or degradation of organic semiconductors under atmospheric conditions causes severe problems for FET performance. The development of the new materials is particularly important for the progress of this field. In this study we introduce new synthetic methodology of fused aromatic hydrocarbons with nitrogen heterocyclic 4,5,12,13-Tetraaza-dibenzo[b,k]chrysene (3), where the nitrogen’s are replaced of carbon atoms to maximize the electronic coupling between semiconducting molecules and to enhance stability, solubility and processability. Scheme 1 shows synthetic route of compound 3. Reaction of commersially available 2-bromonicotinaldehyde with ethylene glicol yielded the 2-bromo-3-(1,3-dioxolan-2-yl)pyridine (1) in 95 % yield. Condensation of

compound 1 with naphthalene-1,5-diamine in the presence of Pd2(dBu)3 catalyst gave in 76 % yield of N1,N5-

bis(3-(1,3-dioxolan-2-yl)pyridin-2-yl)naphthalene-1,5-diamine(2). By cyclization reaction of 2 in acetic acid during 24 hours was obtained target compound 4,5,12,13-Tetraaza-dibenzo[b,k]chrysene in 95% yield.

Scheme1. Synthetic scheme of 4,5,12,13-Tetraaza-dibenzo[b,k]chrysene.

Compound 3 characterized by 1H NMR, 13C NMR, mass and elemental analysis. Slow sublimation provided yellow single crystals of 3 suitable for X-ray analysis. Molecules of 3 are completely planar and form face-to-face π-stacking. Distances between fused rings of π- π interactions are 3.346 Å (Figure 1).

Figure1. Molecule structure and crystal packing of compound 3 Compound 3 as a potential candidate for single crystal field effect transistors and high mobility in OFETs can

be obtained because of conjugated molecules have strong interactions with neighboring molecules.


5

OR-4 Organic Synthesis in Glycerol-based Solvents Adi Wolfson and Dorith Tavor

Green Processes Center, Chemical Engineering Department, Sami Shamoon College of Engineering, Bialik 56, Beer-Sheva,

84100, Israel, [email protected].

Abstract: In the past two decades a variety of green solvents have been proposed, including water, ionic liquids, fluorous solvents, and supercritical fluids. However, their implementation in industrial processes is still limited due to their tedious and non-sustainable synthesis, lack of experimental data and familiarity, as well as operational restrictions and high cost.

Several years ago we presented, for the first time, the use of glycerol-based solvents as alternative sustainable reaction mediums in both catalytic and non-catalytic organic synthesis [1-5]. Glycerol is the main by-product from the conversion of oils and fats in oleochemical production. Moreover, in the past decade, its price has substantially decreased due to an increase in supply from the production and use of fatty acid derivatives in the food, cosmetics, and drugs industries and in biofuel synthesis, i.e., biodiesel. The renewable origin, beneficial physicochemical properties and reusability of glycerol-based solvents, enabled improved product yield and selectivity as well as easy product separation and catalyst recycling. Furthermore, their high boiling point and polarity make them perfect candidates for non-conventional heating and mixing techniques such as ultrasound- and microwave-assisted reactions. Finally, in some reactions, such as catalytic transfer-hydrogenation or transesterification, they can also be used simultaneously as both solvent and reactant [6, 7].

In our ongoing efforts to design a viable protocol that will facilitate the acceptance of glycerol and its derivatives as sustainable solvents, pure glycerol and glycerol triacetate (triacetin) as well as various glycerol-triacetin mixtures were tested as sustainable solvents in several representative organic reactions, such as nucleophilic substitution of benzyl chloride to benzyl acetate, Suzuki-Miyaura cross-coupling of iodobenzene and phenylboronic acid, baker’s yeast reduction of ketones, and transfer hydrogenation of olefins [8]. It was found that reaction performance was affected by the glycerol to triacetin ratio, as the solubility of the substrates in the solvent determined product yield. Thereby, employing optimal glycerol to triacetin ratio resulted in maximum product yield. In addition, using glycerol-based solvents enabled easy and successful separation of the products and recycling of the catalysts. References

1. A. Wolfson, C. Dlugy, Y. Shotland; Environ. Chem. Lett., 2007, 5, 67-71. 2. A. Wolfson, C. Dlugy, D. Tavor, J. Blumenfeld, Y. Shotland; Tetrahedron: Asymmetry, 2006,17, 2043-2045. 3. A. Wolfson, C. Dlugy; Chem. Papers, 2007, 61, 228-232. 4. A. Wolfson, A. Snezhko, T. Meyouhas, C. Dlugy, D. Tavor; Green Chem. Lett. and Rev., 2012,5, 7-12. 5. A. Wolfson, C. Dlugy, D. Tavor; Trends. in Org. Chem., 2011, 15, 41-50. 6. A. Wolfson, C. Dlugy, Y. Shotland, D. Tavor; Tetrahedron letters, 2009, 50, 5951-5953. 7. A. Wolfson, E. Azran, C. Dlugy, D. Tavor; Lett. in Org. Chem., 2011, 8, 504-508. 8. A. Wolfson, C. Dlugy, I. Mordechaiev, T. Sliman, D. Tavor; Canadian J. of Chem., 2014, 92, 240-242.

6

OR-5 Photobactericidal and photochromic textile materials realized by embedding of

advantageous dye using sol-gel technology Boris Mahltiga, Torsten Textorb, Perrin Akcakoca Kumbasarc

a University of Applied Sciences, Faculty of Textile and Clothing Technology, Webschulstrasse 31, D-41065 Mönchengladbach, Germany

b German Textile Research Center North-West, Adlerstrasse 1, D-47798 Krefeld, Germany c Ege University, Faculty of Engineering, Department of Textile Engineering, Izmir, Turkey

Abstract: The presented study reports on the application of the dye Rose Bengal for photobactericidal properties and spirooxazine type photochromic dye for photochromic properties onto textiles by using different sol-gel based coating agents. Photochromic dyes changes rapidly and reversibly from colorless form to colored state when activated by ultraviolet irradiation. Color changing technology offers unique design opportunities to the designer and also has an opportunity to obtain camouflage and UV-protective textiles. The obtained phtochromic textiles were tested by means of UPF (Ultraviolet Protection Factor) and ΔE color difference after UV irradiation. UV irradiation photochromic samples showed over +30 UPF and this effect was developed with concentration of the dye. The prepared photobactericidal textiles were investigated by means of UV/Vis-spectroscopy, scanning electron microscopy and by testing the antimicrobial properties against Bacillus subtilis. The purpose of this treatment was to realize photobactericidal materials which enabled antimicrobial properties in case of illumination with visible light. An antimicrobial effect of the Rose Bengal applied fabrics was observed with and without light exposition, however in case of illumination this effect was significantly stronger indicating a certain photobactericidal effect. This photobactericidal effect strongly depended on the kind of sol-gel coating agent used for embedding of the dyestuff onto the textile.

Bengal Rose 1,3-Dihydro-1,3,3-trimethylspiro[2H-indole-2,3′-

[3H]naphth[2,1-b][1,4]oxazine] Figure 1. Chemical structure of the photoactive dye Bengal Rose and spirooksazine type photochromic dye used for current investigations

References 1. B. Mahltig, D. Knittel, E. Schollmeyer, H. Böttcher; Journal of Sol-Gel Science & Technology. 2004, 31, 293. 2. B. Mahltig, T. Textor; Journal of Sol-Gel Science & Technology. 2006, 39, 111.

7

OR-6 An Investigation on Serum Levels of Cu, Zn, Ca, Mg and P in Goats

İlker CAMKERTENa, Güzin CAMKERTENb, Osman KARABULUTc, Durhasan MUNDANd, Gaye BULUTe

a Department of Internal Medicine, Fakulty of Veterinary Medicine, TR 68100, Aksaray University, Aksaray, TURKEY bDepartment of Veterinary Laborants, School of Technical Vocational , Aksaray Üniversitesi, Aksaray TURKEY cDepartment of Biostatistics, Faculty of Veterinary Medicine, TR 68100, Aksaray University, Aksaray, TURKEY,

dDepartment of Zootecnics , Faculty of Veterinary Medicine, TR 63100, Harran University, Aksaray, TURKEY eDepartment of Gynecology and Obstetrics, Faculty of Veterinary Medicine, TR 68100, Aksaray University, Aksaray, TURKEY

Abstract The aim of this study is the determination of sera Copper (Cu), Zinc (Zn), Calsium (Ca), Magnesium (Mg) ve Potassium (P) levels which are important for animal health and yield. In this study goats (ntotal=117) which are located in the central (n=20) and district of Şanlıurfa were used as the material. Cu, Zn, Ca, Mg and P levels were measured in the serum obtained from the blood samples by ICP-OES at Harran University Center Research Laboratory. The values were given as mg/kg.

Tablo1. Goats mineral levels in the Central and district of Şanlıurfa Cu (mg/L) Zn (mg/L) Ca (mg/L) Mg (mg/L) P (mg/L)

Şanlıurfa 0,17±0,01a 0,11±0,01 a 19,33±0,90a 4,50±0,12a 10,43±0,45a Suruç 0,17±0,01a 0,10±0,01ab 19,19±0,75a 4,49±0,20a 10,25±0,49a Hilvan 0,18±0,01a 0,09±0,00b 15,98±0,53bc 4,23±0,11a 8,24±0,52b Siverek 0,15±0,01ab 0,09±0,00b 16,42±0,55b 4,17±0,12a 7,98±0,53b Viranşehir 0,13±0,01b 0,06±0,00c 13,72±0,37c 3,58±0,09b 7,90±0,47b Bozova 0,13±0,01b 0,09±0,01b 15,38±1,31bc 3,08±0,26c 10,04±0,89a P ,000 ,000 ,000 ,000 ,002 Referance 08-1.2 1 0.8-1.2 1 92-116 2 35-52 2 10-112 2

All the resulting values were lower than their reference values. The lowest mineral levels were detected in Viranşehir. In conclusion, goats should be carefully examined in terms of yield losses and diseases connected to lack of minerals. Key Words: Şanlıurfa, Goat, Serum, Cu, Zn, Mg, Ca, P References 1. Peter G.G. Jackson, Peter D. Cockcroft. Clinical Examination of Farm Animals – App3, Copyright © 2002 by Blackwell Science Ltd. (04.06.2015) Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/9780470752425.app3/pdf 2. Arif Altıntaş, Ulvi Reha Fidancı. 1993. Evcil Hayvanlarda ve İnsanda Kanın Biyokimyasal Normal Degerleri. A. Ü. Vet. Fak. Derg. 40 (2): 173-186

http://onlinelibrary.wiley.com/doi/10.1002/9780470752425.app3/pdf

8

OR-7 Antioxidant Capacity of Verbascoside Isolated from Teucrium chamaedrys L. subsp.

chamaedrys Mahfuz ELMASTAŞa,b, Beşir İsnaçb, Ayşenur TAŞb, Hüseyin AKŞİTb, Nusret GENÇb

aDepartmen of Chemistryt, Faculty of Arts and Sciences, Gaziosmanpaşa University.TR 60240 Tokat, Turkey. bPlant Research Laboratory, Faculty of Arts and Sciences, Gaziosmanpaşa University.TR 60240 Tokat, Turkey.

Abstract: Natural antioxidants are extensively studied for their capacity to protect organisms and cells from damage that induced by oxidative stress, the latter being considered a cause of ageing, degenerative diseases (1-3). In this study antioxidant capacity of verbascoside isolated from Teucrium chamaedrys L. subsp. chamaedrys was evaluated. Teucrium chamaedrys L. sups Chamaedrys was collected from Bursa. Methanol/dichloromethane (1/1) extract showed the highest antioxidant capacity than the other solvent systems (hexane/dichloromethane, ethyl acetate/dichloromethane, (1/1)). Therefore methanol/dicloromethane extract of Teucrium chamaedrys L. sups Chamaedrys was used to isolate the verbascoside. Chromatographic techniques including column, flash and PTLC were employed to isolate the compound. The structure was elucidated by 1D-, 2D-NMR and others spectroscopic techniques. In order to determination of antioxidant activity of isolated molecule, the free radical scavenging activity and reducing power antioxidant activities tests were applied. The results showed that isolated molecule has a higher antioxidant activity than synthetic antioxidants (BHA, BHT and Trolox).As a result, verbascoside (C29H36O15) were isolated from Teucrium chamaedrysL. Subsp. chamaedrys and characterized successfullyas antioxidant agent.

O

OH

OH

O

O

O

O

O

OH

OH

OH

OH

OH

OH

(E)-((2R,4S,5R,6R)-6-(3,4-dihydroxyphenethoxy)-2-(hydroxymethyl)-5-methyl-4-((2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-3-yl) 3-(3,4-

dihydroxyphenyl)acrylate Figure 1.Isolated compound and its antioxidant activity

*This study is supported by a grant (Project Number: 2011/16) from Scientific Research Projects Committeeof Gaziosmanpaşa University.

References

1- L. R. Fukumoto, G. Mazzo;J. Agric. Food Chem.2000,48. 3597–3604. 2- M. H. Gordon;Nat. Prod. Rep.1996. 13, 265–273. 3- A, C, Moffat, Jackson, J. V., Moss M. S., and Widdop, B.,Clarke’s isolation and identification of drugs, The Pharceutical Press,

Londra U.K. 1986.

http://www.ncbi.nlm.nih.gov/pubmed/8760864

9

OR-8

Secondary Metabolites from Origanum rotundifolium Boiss. and Antioxidant Activities

Ramazan Erenler, Ozkan Sen Department of Chemistry, Faculty of Art and Science, Gaziosmanpasa University, 60240 Tokat, Turkey

Abstract: Origanumgenus belonging to the Lamiaceae family is represented by 23 species and six hybrids in the flora of Turkey, 14 of

which are endemic.1Origanum species have been used as folk medicine for treatment of some diseases for years. These species are well known for their essential oils which have been applied in the flavoring of various foods.2 The plant materials were dried and powdered then extracted with hexane, ethyl acetate, methanol and water. The aqueous part of water extract was partitioned with ethyl acetate to yield the extract exhibited the best antioxidant activities. Therefore, secondary metabolites were isolated from this extract. Apigenin (1), ferulic acid (2), vitexin (3), caprolactam (4), rosmarinic acid (5), globoidnan A (6) were isolated by chromatographic techniques (column chromatography, preparative HPLC) and spectroscopic methods (1D-NMR, 2D-NMR, LC-TOF/MS) were used for elucidation of isolated compounds. The antioxidant activities of isolated compounds were carried out using different antioxidant assays, including 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH) scavenging, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging, reducing power. Butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and trolox were used as standards. Compounds(3, 5 and 2) exhibited high DPPH• scavenging activity. 3 and 6 showed the higher ABTS•+ scavenging activity than the standards. The reducing power activity decreased as the order: BHA >globoidnan A> BHT >ferulic acid >Trolox>rosmarinic acid >vitexin> Apigenin >caprolactam. Acknowledgements This work was supported by The Scientific and Technological Research Council of Turkey (TUBITAK, 113Z195). References 1. P. H. Davis, R. R. Mill and K.Tan. Flora of Turkey and the East Aegean Islands. University Press, Edinburgh: 1988. 2. C. Busatta, R. S. Vidal, A. S. Popiolski, A. J. Mossi, C. Dariva, M. R. A. Rodrigues,; F. C Corazza, M. L. Corazza, J. V. Oliveira and R. L

Cansian. Food Microbiol. 2008, 25, 207-211.

10

OR-9

Separation and Preconcentration of Palladium on Magnetic Polyhydroxybutyrate-b-Polydimethylsiloxane (PHB-b-PDMS) and Its Determination in Environmental

Samples by Flame Atomic Absorption Spectrometry

Mustafa Tuzena, YunusEmreUnsala, Mustafa Soylakb, BakiHazerc

aGaziosmanpasaUniversity, Faculty of Science and Arts, Chemistry Dept., 60250 Tokat, Turkey bErciyesUniversity, Faculty of Science, Chemistry Department, 38039 Kayseri, Turkey

c BulentEcevitUniversity, Department of Chemistry, 67100 Zonguldak, Turkey E-mail: [email protected]

Polyhydroxyroxybutyrate-b-polydimethylsiloxane is biodegradable polyester block copolymer (1) a new method has been developed for the separation/preconcentration of trace level of palladium usingmagnetic Polyhydroxybutyrate-b-Polydimethylsiloxane (PHB-b-PDMS). The separation of palladium(II) adsorbed as 1-nitroso-2-naphthol-3, 6-disulfonic acid chelates on magnetic PHB-b-PDMS from aqueous solution was simply achieved by applying an external magnetic field via a permanent magnet.Various parameters on the separation and preconcentration of palladium ions such as pH, amount of adsorbent, amount of 1-nitroso-2-naphthol-3, 6-disulfonic acid, condition of eluting solution, the effects of matrix ions were examined. The detection limit of this method for palladium was 1.1 μg L−1. The relative standard deviation (RSD) was found 5%. The advantages of this new method include rapidity, easy preparation of sorbents and a high concentration factor. The proposed method has been applied to the determination of palladium(II) ions at trace levels in real samples such as waste water, tap water, river water, sea water, vegetable and soil samples by flame atomic absorption spectrometry.

References

1. M. Tuzen, Y.E. Unsal, M. Soylak, Z. Akkirman, B. Hazer,2013,Int. J. Food Sci. Tech.48, 2384-2390.


http://scholar.google.com.tr/scholar?q=1-nitroso-2-naphthol-3+6-disulfonic+acid&hl=tr&as_sdt=0&as_vis=1&oi=scholart&sa=X&ei=8Jo-VcaFK4HiUMvYgOAD&ved=0CBgQgQMwAA




11

OR-10

Conversion Treatment of Thin Chromium Layers Deposited on High Carbon Steels Substrates*

Younes BENARIOUA Département de Génie Mécanique, Faculté de Technologies, Université de M’sila, BP 166 - M'sila 28000, Algérie.

Abstract: The use of transition metal carbides as material coatings to improve the mechanical and chemical properties of mechanical parts has shown a large and extensive development[1, 2]. Among these metal compounds, chromium carbides film which has a better chemicals and mechanicals properties can be used as candidate for this purpose. Coatings of chromium carbide films deposited by different deposition techniques including chemical and physical vapor deposition present a low adhesion to their substrates which is considered as disadvantage[3, 4] The aim of the present paper is to obtain chromium carbide thin film having a better mechanical behavior by annealing treatment of chromium films deposited on high carbon steel substrates. In the first step of this study, high carbon steel substrate is covered with a pure chromium thin layer deposited by electrolytic method. In the next step, samples (layer/substrate) were exposed to annealing at different temperatures ranging from 600°C to 1100°C in steep of 100°C. The structure and morphology of the layers were investigated respectively by X-ray diffraction and scanning electronic microscopy. The adhesion and hardness of films were measured by means of a scratch tester and microhardness tester. It was observed that the film was totally, partially or not transformed into chromium carbide, depending on heat treatment temperature. The transformation of chromium layer in chromium carbide takes place firstly at the interface between the film and the substrate, then it expands through the whole film thickness, toward the outer surface, by diffusion of carbon coming from the substrate. As a result, complete transformation of the chromium film in chromium carbide is obtained when an annealing temperature of 1100°C is used. A higher adhesion and hardness, is found for this coating if compared to the one obtained on samples treated at lower temperatures and to other literature data on coatings having similar thickness and composition. * This study is supported by the Thematic Agency Research of Science and Technology (ATRST) of Algeria under research

contract of thematic project 100/2015,

References

1. S.C. Kwon, M. Kim, S.U. Park, D.Y. Kim, D. Kim, K.S. Nam, Y. Choi, Surf. Coat.Technol. 183, 2004, 151. 2. K. Nakaniahi, H. Takeda, H. Tachikawa, T. Arai, The 8th International Congress on Heat Treatment of Metals, Kyoto, Japan, Nov. 17-20,1992, p. 507. 3. C.Y. Wei, F.S. Chen, Mater. Chem. Phys. 91, 2005, 192. 4. Y. Benarioua , R. Boubaaya , J. Lesage, D. Chicot; Surface & Coatings Technology,227, 2013, 65–69

12

OR-11

Evaluation of the Raman Spectroscopy Coupled with Partial Least Squares Regression Analysis for Diagnosis of Hepatitis C.

H. Nawaza, N. Rashida, M. Bilalb, M. Saleemb,I. Amin e, M. Iqbala, M. Rahmana, P. Kniefc,H J Byrned, S. M.Baig,aM. Ahmedb aNational Institute for Biotechnology and Genetic Engineering (NIBGE), P.O.Box 577, Jhang Road

Faisalabad, Pakistan. b.National Institute of Lasers and Optronics (NILOP), Islamabad, Pakistan.

c. Royal College of Surgeons Ireland (RCSI), Dublin 2, Ireland. d. FOCAS Research Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland.

e. PINUM Hospital, Faisalabad, Pakistan.

*Corresponding Author: Dr. Haq Nawaz E-mail: [email protected]

Abstract: Raman spectroscopy has been used to identify the biochemical changes associated with the presenceof the Hepatitis C virus (HCV)

in infected human blood plasma samples as compared to healthy samples as control, in an effort to establish the Raman spectral

markers of hepatitis infection, which could be used for diagnostic purposes. Moreover, multivariate data analysis techniques,

including Principal Component Analysis (PCA) and Partial Least Square Regression (PLSR) are employedto further analyse the

biochemical origin of the spectral markers of HCV infection and a PLSR modelisdeveloped to predict the viral loads of the HCV

infected plasma on the basis of the biochemical changes caused by the viral infection. Raman spectral features related to RNA/DNA

bases, including those at 1247 cm-1 and 1322 cm-1, are observed only in the plasma of diseased samples as compared to control,

indicating their association with the HCV. In addition,spectral changes related to lipids are also observed which can be associated

with their involvement in the replication process of the virus after infection. PCA differentiated the “normal” and “HCV” groups of

the Raman spectra and the PC loadings highlight the biochemical origin of the spectral changes associated with HCV infection. PLSR

modelling was found to be 93.8 % accurate in predicting the viral loads of the HCV samples on the basis of the Raman spectral

changes caused by the virus during the process of the development of Hepatitis C.


13

OR-12

Kendiliğinden Yerleşen Betonda Rötre Azaltici KimyasalKatkinin Dayanima Olan Etkisi

İlhami Demir, İlker Kalkan, Ali Payidar Akgüngör, Özer Sevim Kırıkkale Üniversitesi, Mühendislik Fakültesi, İnşaat Mühendisliği, Yahşihan, Kırıkkale, Türkiye

Özet: Kendiliğinden yerleşen beton (KYB) özellikle hazır-beton sektörü, onarım güçlendirme işleri ve prefabrik inşaat sektörü başta olmak

üzere yapıların beton ile ilgili tümdallarında giderek daha fazla uygulama alanı bulmaktadır. Vibratör gerektirmeden yerleşmesi,

yüksek dayanım özelliği gibi nedenlerle yüksek performanslı beton üretimine olanak vermektedir.

Günümüzde en çok kullanılan özel beton çeşitlerinden biri kendiliğinden yerleşen betondur. Kendiliğinden yerleşen betonun

davranış özelliklerini bilmek için öncelikle kendiliğinden yerleşen betonun (KYB) yapısının iyi analiz edilmesi gerekir. Bu nedenle de

KYB’nin fiziksel ve kimyasal yapısının, onu oluşturan yapı malzemelerinin ve bu malzemelerin birbirleriyle uyumlu çalışmalarının

bilinmesi gerekir.

Son yıllarda düşük su/bağlayıcı oranına sahip ve çatlak oluşumuna daha eğilimli yüksek kalitedeki betonların üretimi ile birlikte

durabilite konusunda çatlak oluşumunun oynadığı zararlı rol, rötre ve erken yaş çatlakları konusuna duyulan ilginin yeniden

artmasına yol açmıştır. Bu modern betonların sahip oldukları çatlak duyarlığı sahip oldukları yüksek çimento dozajı ile düşük

su/bağlayıcı oranının neden olduğu otojen rötreye bağlı etkilerle ilişkili olmaktadır.

Bu çalışmada rötre azaltıcı katkının kendiliğinden yerleşen beton (KYB) karışımların taze haldeki özellikleri ile yarmada çekme

dayanımı ve basınç dayanımı irdelenmiştir.

Anahatar Kelimeler: Kendiliğinden Yerleşen Beton, Rötre, Rötre Azaltıcı, Eğilme ve Basınç Dayanımı

14

OR-13 Spectroscopic Studies on 9H-Carbazole-9-(4-phenyl) Boronic Acid Pinacol Ester by DFT

Method

Emine BABUR SASa, Mustafa KURTa, Mustafa CANb, Nesrin HORZUMb, Ahmet ATACc

a Department of Physics, Ahi Evran University,TR-40100, Kirsehir, Turkey, [email protected], [email protected]

bDepartment of Engineering Sciences, Faculty of Engineering, Izmir Katip Celebi University, TR-35620 Izmir, Turkey, [email protected], [email protected]

c Department of Physics, Celal Bayar University,TR-45100, Manisa, Turkey, [email protected]

Abstract: 9H-Carbazole-9-(4-phenyl)boronic acid pinacol ester (9-CPBAPE) molecule was investigated by FT-IR, 1H and 13C NMR spectra. FT-IR spectrum was recorded in the solid phase. 1H, 13C-NMR spectra were recorded in dimethyl sulfoxide (DMSO) solution. The results of theoretical calculations for the spectra of the title molecule were compared with the observed spectra. The theoretical calculations for the molecular structure and spectroscopic studies were performed with DFT (B3LYP) and 6-311G (d,p) basis set calculations using the Gaussian 09 program. The complete assignments are performed on the basis of the potential energy distribution (PED).



15

OR-14 Efficient Synthesis ofIndene-Aldehyde Derivatives Catalyzed by Secondary Amine

Catalysts HuiMaoa, Jung WoonYanga

aDepartment of Energy Science, Sungkyunkwan University, Suwon 440-746, Republic of Korea Abstract: Substituted indene derivatives are valuable synthetic targets in organic and medicinal chemistry because of their important biological activities and applications in functional materials. These indene-based materials have shown a wide range of biological activities such as antineoplastic, anti-inflammatory, aromatase inhibitory, and cytotoxic activities. A variety of effective approaches were already reported for indene synthesis. However, many of these existing methods suffer from shortcomings includinglow tolerance of functionality, the necessity of expensive transition metal catalysts and harsh reaction conditions. Herein, we describe a novel method for the synthesis of various substituted indene aldehydes using secondary amine catalystsunder mild reaction conditions.

Scheme1.Formation of indene aldehyde derivativescatalyzed by secondary amine catalysts

References

1. Y. Huang, A. M. Walji, C. H. Larsen, D. W. C. MacMillan, J. Am. Chem. Soc.,2005, 127, 15051-15053. 2. K. B. S. Magar, Y. R. Lee, Org. Lett.,2013, 15(17), 4288-4291.

16

OR-15 Synthesis of Multiwall Carbon Nanotube - p-Phenylenediamine - Maleic Anhydride - 1-

Heptene Nanocomposite Elvin MALIKOVa, Oktay AKPEROVa, Mustafa MURADOVb, Goncha EYVAZOVAb

aDepartment of Chemistry, High Molecular Compounds chemistry sub-department,Baku State University, AZ 1148, Z.Khalilov str.,23, Baku, Azerbaijan

bDepartment of Physics, Sub-department of Chemical Physics of Nanomaterials,Baku State University, AZ 1148, Z.Khalilov str.,23, Baku, Azerbaijan

Abstract: Carbon nanotubes (CNTs) have received considerable attention recently owing to their unique electronic and mechanical properties that are expected to lead to breakthrough industrial applications [1]. CNTs exhibit a well-known tendency to form agglomerates due to van der Waals forces, which makes them extremely difficult to disperse and align in a polymer matrix. The functionalization of CNTs is an effective way to prevent nanotube aggregation, which helps in dispersing and stabilizing carbon nanotubes within a polymer matrix. The two main pathways suggested for the covalent grafting of polymers to CNTs are the “grafting from” and the “grafting to” approaches [2-4]. In this paper multiwall carbon nanotubes (MWCNTs) synthesized by CVD from acetylene over an Fe,Co/alumina catalyst were oxidized by KMnO4 solution to form functionalities on wall defects and end caps. The “grafting to” approach was used to graft maleic anhydride-1-heptene copolymer (MAHP) to oxidized-MWCNTs using p-Phenylenediamine (PPDA) bridge. First of all PPDA was added to the oxidized-MWCNTs to form a salt. Then this salt was reacted with MAHP to form a grafted structure. The proof of completion of the “grafting to” process was obtained by XRD, Raman and FTIR methods. FTIR also confirmed the presence of the characteristic peaks of the anticipated zwitterion and amine-amide conversion. TEM and SEM revealed that the nanotubes are uniformly covered with the polymer which shows the effectiveness of the method. The solubility of the MWCNTs was improved by the functionalization because, grafting MWCNTs to MAHP helps in reducing the nanotube-nanotube adhesion and the tendency to form entangled stacks, which generally make MWCNTs unusable for manufacturing advanced plastic materials. The novelty of this work is that MAHP macromolecules are attached to oxidized-MWCNT using PPDA bridge via the “grafting to” approach for the first time at room conditions. The long copolymer chains in the resulting material are able to screen and protect the nanotubes from entanglement during dispersion. The suggested process was carried out at room conditions and therefore it can be considered as a feasible alternative for carbon nanotube functionalization targeted at polymer composite applications.

References

1. X. Wang, Q. Li, J. Xie, Z. Jin, J. Wang, Y. Li, K. Jiang, S.S. Fan;Nano Lett.2009, 9(9), 3137-3141. 2. N.G. Sahoo, S. Rana, J.W. Cho, L. Li, S.H. Chan;Prog Polym Sci.2010, 35, 837-867. 3. E.Y. Malikov, M.C. Altay, M.B. Muradov, O.H. Akperov, G.M. Eyvazova, R. Puskás, D. Madarász, Á. Kukovecz, Z. Kónya;Physica E. 2015, 69, 212-218. 4. E.Y. Malikov, M.B. Muradov, O.H. Akperov, G.M. Eyvazova, R. Puskás, D. Madarász, L. Nagy, Á. Kukovecz, Z. Kónya;Physica E.2014, 61, 129-134.

17

OR-16 Design of an Appropriate Semi-Interpenetrating and Full-Interpenetrating Polymer

Network Chitosan for Nano Drug Delivery Amilah*, Nike TriendahAsih**

*) Chemistry Department, Faculty of Mathematics and Natural Science, University of Indonesia Phone: +62-852-7413-4736

E-mail: [email protected] **) Chemistry Department, Faculty of Mathematics and Natural Science,

Indonesia University Phone: +62-858-1719-6070

E-mail: [email protected]

Chitosan is a non-toxic biocompatible polysaccharide thathas been widely explored for drug delivery agent, tissue engineer and cosmetic. Chitosan is among of the most exploredpolysaccharides in biomedical science. It has many advantages that are not availablein most natural polysaccharides. However, chitosan has few disadvantages like as have weak mechanical strength and swelling/deswelling respone. Because of these disadvantages, chitosan requires further development to achieve the targeted efficiency results desired. To overcome some of the disadvantages of a pristine chitosan, it is most imperative to functionalize pristine chitosan with suitable functional groups. These functional groups include the primary hydroxyl group, and amide group that are located in backbone of chitosan, in which they act as a site of chemical modification, and are responsible for the polymer’s reactivity. Chitosan has limitation as a nano-drug delivery because of the limitation in it’s chemical modification. Modification of chitosan is very important to carry out it’s purpose as a

nano-drug delivery. The stability of the nano-drug delivery is an important parameter for a successful passive targeting. If the particles circulated in the blood-streams for a longer period of time, therefore the particles can reach the target sites more effectively. Thus, it is highly desirable to understand the design of the Interpenetrating Polymer Network (IPN) base on polysaccharides in order tosynthesizea polymer that can be applied as nano-drug delivery. The purpose of this review is to give an overview of the strategy and design foran appropriate Semi- Interpenetrating Polymer Network (Semi-IPN)


18

OR-17 Preparation ofChitosan-Gum Arabic/n-eicosane Microcapsules byComplex Coacervation

Kasım AKSOYa, Cemil ALKANb

a Süleyman Demirel University, Technical Sciences Vocational School, Biomedical Device Technology Program, Isparta, TURKEY

bGaziosmanpaşa University, Department of Chemistry, Tokat, TURKEY [email protected]

In this study, microencapsulated n-eicosane as phase change heat energy storage material was prepared by

complex coacervation method. In the complex coacervation method, oppositely charged polymers were used to

form microcapsule shell. Polymer complex formed at suitable pH value between the positive and negative

charged polymer chains is deposited on microcapsule core material in emulsion system. In the system, pH is

adjusted to the value that two polymers are oppositely charged. Finally, complex macromolecular structure

formed between the polyanion and polycation polymers in the emulsion system were cross-linked by a cross-

linker agent to increase thermal, chemical and mechanical stability of prepared microcapsules. In this study,

chitosan and gum Arabic polymers were used as polycation and polyanion polymers, respectively. Span 20 with

8.6 of HLB value was used as surfactant. Core/shell and polycation polymer:polyanion polymer ratios were

determined as 1:1,5 and 1:1, respectively according to the finding from our previous studies [1,2]. The particle

size, morphology, chemical structure and thermal properties such as melting and crystallization temperature and

enthalpy were analyzed by particle size analyzer, SEM, FT-IR spectroscopy and DSC methods, respectively.

The results showed that microcapsules have spherical shape with particle sizes between 15.49 µm and 65.92

µm.Microencapsulated n-eicosane have70.35 J/g melting enthalpy at 33.3 oC and -71.35 J/g crystallization

enthalpy at 33.8 oC.

Key Word: Microcapsules, complex coacervation, phase change material, n-eicosane, chitosan and gum arabic.

References

[1] K.Aksoy and C.Alkan,2013,8th International Conference Textile Science-TEXSCI 2013, 50-51,September 23-

25,Liberec,Czech Republic.

[2] K.Aksoy, C.Alkan,2014,V. Ulusal Polimer Bilim Ve Teknolojisi Kongresi,26-27,Eylül 1-4,Tokat, Türkiye.


19

OR-18 Removal of Cr(III) and Cr(VI) Ions from Aqueous Solutions Using Modified Cotton

Cellulose with Polycarboxylic Acids Nazife Korkmaza, Sennur Alay Aksoya, Fethiye Gödeb

aSüleyman Demirel University, Textile Engineering Department, Isparta, Turkey. bSüleyman Demirel University, Department of Chemistry, Isparta, Turkey.

[email protected]

Abstract Pollution of ground water and surface water by heavy metals such as lead, cadmium, copper, chromiumand mercury is one of the most serious environmental problems due to their toxic nature and other adverse effects (1). These heavy metals are not biodegradable and tend to accumulate in living organisms. They can cause various diseases and disorders which represent a serious threat for human population as well as the fauna and flora of receiving water bodies as discharges in waste water. Hence, the removal of heavy metal ions from aqueous solution before discharge is essential. Among these heavy metal ions, chromium especially in its hexavalent form has toxic effects. At high exposure levels, Cr (VI) causes respiratory cancers (2).Most of conventional methodssuch as chemical precipitation, electrolysis, membrane separation, ion exchange, reverse osmosis and biosorption suffer from some drawback such as high capital or high operating cost or disposal of resulting solid waste. On the other hand, adsorption using sorbents is one of the most popular and effective processes for the removal of heavy metals from wastewater because of the flexibility in design and operation and environmental friendly behavior. In recent years, the investigation of low-cost materials such as agricultural by products, industrial wastes and biological materials as adsorbents for the removal of heavy metal from industrial wastewater has been considered. According to the findings, the heavy metal adsorption capacities ofthe modified cellulose by forming an ester linkage were significant and levels of uptake were comparable to commercial ion exchange type resins (3). In this study, the Cr(III) and Cr(VI) ions sorption ability of cross-linked cotton cellulose with different polycarboxylic acids by forming ester linkage were investigated. Butane tetra carboxylic acid (BTCA) and maleic acid (MA) catalyzed by sodium hypophosphite were cross-linked to cellulose by esterification reaction. Fourier transform infrared spectrometer (FT-IR) was used to verify the presence of functional carboxylic acid groups in cross-linked cellulose. The morphology of the modified cotton cellulose was studied by scanning electron microscope (SEM). Furthermore, the adsorption mechanism was systematically investigated. The percentages of Cr(III) adsorbed on the 0.1 g adsorbent which modified cotton cellulose with MA and BTCA were 69.94 %and 62.23 %, respectively. Besides, the percentages of Cr(VI) adsorbed on the 0.1 g adsorbent which modified cotton cellulose with MA and BTCA were 66.54 % and 66.04%, respectively. It was concluded that modified cotton cellulose with BTCA and MA by forming ester linkage could be used for the removal of Cr(III) and Cr(VI) ions from the waste water. References 1. X. Yu, S. Tong, M. Ge1, L. Wu, J. Zuo, C. Cao, W. Song, Journal of Enviromental Sciences, 2013, 933-943 2. IARC, 1990. Monograph on the Evaluation of Carcinogenic Risk to Humans, vol. 49, Chromium, Nickel and Welding. International Agency for Research on Cancer, Lyon. 3. D.W. O’Connell , C. Birkinshaw , T. F. O’Dwyer, Bioresource Technology, 2008,99, 6709-6724.

20

OR-19 Oxidative Stress Parameters in Anesthetized with Ketamine-Xylazinethe Bozova

Greyhounds Güzin CAMKERTENa, İlker CAMKERTENb, Nihat ŞINDAKc, Gaye BULUTd

aDepartment of Veterinary,Vocational-Technical School, Laboratory and Veterinary Health Program,Aksaray University, TR-68100, Aksaray, Turkey

bDepartment of Internal Medicine, Faculty of Veterinary Medicine, Aksaray University, TR-68100, Aksaray, Turkey

cDepartment of Surgery, Veterinary Medicine, Siirt University, TR-56100, Siirt, Turkey

dDepartment of Gynecology and Obstetrics, Faculty of Veterinary Medicine, Aksaray University, TR-68100, Aksaray, Turkey

Abstract Background:The combination of ketamine HCl and xylazineHCl anesthesia is very useful and safe in dog. “Bozova Greyhounds” were raised villages of around Bozova town of Sanliurfa city in Turkey and they were

used to hunting. To our knowledge, it is only a few article reported on ketamine and xylazin anesthesia effects of clinical parameters but not about oxidative stress parameters on the greyhounds and no study has been reported anesthesia on Bozova Greyhounds. Therefore, the purpose of this study is to evaluate the oxidative stress parameters in anesthetized with ketamine-xylazineBozova greyhounds. Materials and methods:In this study eight greyhounds which were in different age, body weight and sex were used as the material. The animals which were came in clinic with different complaints injected with the ketamine (10 mg/kg) and xylazine (1 mg/kg) intramuscularly. The findings were recorded before and 30 minute of anesthesia. Blood samples were collected from the vena cephalicaantebrachii into two tubes with and without coagulant. Erythrocyte Superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA) and plasma catalase (CAT) were measured by validated standard methods.Serum copper, zinc, manganese levels were determined by an ICP-OES. Results: Table 1.Oxidative stress paremeters before and after anestezia in greyhounds

Discussion:The SOD Activity is increased in tissues that are much using oxygen and with the rise of tissue pO2. The first 30 minutes of anesthesia, partial oxygen pressure (PaO2) usually decreases. During anesthesia,the drop of PaO2 is causes a reduction in the SOD activity. As a result, the using of ketamine-xylazine anesthetics in dogs (especially Bozova Greyhounds) can be said that in terms of sera Cu, Zn, Mn trace elements and oxidative stres are highly secure and available. Key Words:Bozova Greyhounds, oxidative stress, SOD, CAT, GPx, MDA

ntotal = 8 Before Anestezia After Anestezia

mean SE mean SE P Sod 361,4 31,4 237,3 40,8 < 0.05 Cat 245,4 27,2 276,9 31,8 - Gpx 9561 2103 9676 1951 - Mda 8,02 2,20 3,67 0,16 -

Cu (Mg/L) 1,70 0,06 1,69 0,06 - Zn (Mg/L) 2,70 0,90 5,79 1,42 - Mn (Mg/L) 0,20 0,06 0,32 0,08 -

21

OR-20 Structural, Electronic, Elasticand Phonon Properties of OsAl in B2 Crystal Structurefrom

First-principles

Raşit UMUCUaand Mustafa ÖZDURANa aDepartment of Physics,Faculty of Art and Science, Ahi Evran University, Bağbaşı-TR-40200 Kırşehir, Turkey

A theoreticalstudy of structural, electronic, elasticandphononproperties of OsAlcompound is

presentedbyperforming ab initiocalculationsbased on thedensity-functionaltheoryusingtheplane-

wavepseudopotentialmethod. Thegeneralized-gradientapproximation (GGA) is chosenfortheexchange–

correlationenergy. Thecalculatedstructuralparameters, such as thelatticeconstant, bulkmodulus, second-

orderelasticconstants, electronicbandstructuresandtherelated total density of statesarepresented.

OurcalculationspredictthatOsAl is a metal in CsClstructure. Theelasticconstantswerederivedfromthestress–

strainrelation. Phonon-dispersioncurveswereobtainedusingthefirstprincipleslinear-responseapproach of

thedensity-functionalperturbationtheory.

REFERENCES [1] J.J. Spokas, C.H. Sowers, D.O. Van Ostenburg, and H.G. HoevePhys. Rev. B, 1, 2523 (1970). [2] D. Nguyen-Manh, D.G. Pettifor, Intermetallics, 7, 1095-1106 (1999).

22

OR-21

Thermal energy storage properties of poly(methyl methacrylate)/stearic acid micro/nano capsules*

Ahmet SARI*,Ayşe Gül KÜÇCÜK, Alper BİÇER, Cemil ALKAN

Department of Chemistry, Gaziosmanpaşa University, 60240, Tokat, Turkey

*[email protected]

Fatty acids categorized as solid-liquid organic PCMs have attractive thermal energy storage (TES) properties like reversible phase change, high thermal durability and goodchemical stability with different environmental matters [1]. However, the fatty acids need packaging materials to hold them in liquid or solid state in order to avoid their contact with near surrounding [2]. The micro or nano encapsulation of PCM can prevent its seepage from the structure, lessen the interference with its close environment, resist its volume change and improve enlarge its heat-transfer area, light permeability, controlled releasing, and thermal stability properties [3]. Therefore, in recent years, the encapsulated PCMs have been prepared to use them in the fabrication of thermal regulating fibers, fabrics, coatings and foams [4], insulation panels, the exterior walls of buildings [5] and electronic equipments [6]. In this study, it is aimed to prepare, characterize and determine the latent heat thermal energy storage properties of micro/nano encapsulated stearic acid (SA) with polymethylmethacrylate(PMMA) shell. The micro/nano capsules were prepared effectively as novel encapsulated phase change material(EPCM) via emulsion polymerization. The fourier transform infrared (FTIR) spectroscopy analysis confirmed that the polymerization reaction was carried out successfully. The polarized optical microscopy (POM), scanning electron microscopy (SEM) and particle size distribution (PSD) analysis showed that the prepared PMMA/SA micro/nano capsules with 1:1 styrene/SA ratio had spherical shape-appearances with micro/nano sizes. The differential scanning calorimetry (DSC) measurements revealed that the micro/nano capsules containing the highest paraffin content had melting temperature of 64.58°C and latent heat storage capacity of 124.98 J/g. Thermogravimetry analysis (TGA) results verified that the encapsulated PMMA/SA(1:1) had good thermal reliability and chemical stability after repeated melting/freezing cycles for 5000 times. Furthermore, the synthesized PMMA/SA(1:1) micro/nano capsules had conceivable thermal conductivity values and reversible phase change behaviors. Based on all results it can be also concluded that the prepared PMMA/SA(1:1) micro/nano capsules had good thermal energy storage potential for low temperature-solar passive TES purposes especially for buildings and thermal regulating of textile materials. *The author would like to acknowledge by Scientific and Technological Research Council of Turkey (TÜBİTAK) for financial support (Project No:112T864). References: [1] Hadjieva M, Kanev St, Argirov J, Solar Energy Material and Solar Cells 1992; 27:181–187. [2] Zhao CY, Zhang GH. Renewable and Sustainable Energy Reviews 2011;15:3813–32. [3] Hawlader MNA, Uddin MS, Khin MM. Applied Energy 2003;74:195–202 [4] Sarı A, Alkan C, Karaipekli A. Applied Energy 2010; 87:1529-1534. [5] Jeong SG, Jeon J, Seo J, Lee JH, Kim S. Energy Conversion and Management 2012; 64:516-521. [6] Su JF, XY, Wang SB, Wang YH, Zhao, ZH, Energy Conversion and Management 2012; 55:101-107. [7] Jackson WB,Gould RD, Mulligan JC.8th AIAA/ASME Joint Thermophysics and Heat Transfer Conference, 24-26 June 2002.

mailto:*[email protected]

23

OR-22

AB Initio Molecular Dynamics Study OF Structural Properties OF FeF2as aFunction ofPressure

Cihan KÜRKÇÜ*,Ziya MERDAN**, Hülya ÖZTÜRK*, Sümeyra YAMÇIÇIER***, Çağatay YAMÇIÇIER and Cemile KÜRKÇÜ*

*Department of Physics, Faculty of Arts and Sciences, Ahi Evran University, TR-40200, Kirsehir, Turkey.

[email protected], [email protected], [email protected] **Department of Physics, Science Faculty, Gazi University, TR-06500, Ankara, Turkey. [email protected]

***Vocational School of Health Services, Ahi Evran University, TR-40100, Kirsehir, Turkey. [email protected], [email protected]

Abstract:

We have studied the structural properties of the antiferromagnetic FeF2 using density functional theory (DFT) methods under rapid hydrostatic pressure up to 300 GPa. FeF2 crystallizes in tetragonal rutile-type structure with space group P42/mnm at ambient conditions. FeF2 undergoes a phase transformation from the tetragonal structure to CaCl2-type orthorhombic structure with space group Pnnm at 136 GPa. This phase transformation is in good agreement with other theoretical and experimental studies. This phase transformation is also studied by total energy and enthalpy calculations.

Scheme1.(Color on-line)Crystal Structures with polyhedral views of FeF2. (top) at zero pressure and (bottom) at 136 GPa.







24

OR-23

Developed of PotentiometricSensitive Sensorto Antipsychotic Risperidone ÖmerIŞILDAKa, AyşenurBİRİNCİa

aGaziosmanpasaÜniversity, Faculty of Science and Education, Department of Chemistry, Tokat, Turkey [email protected]

Abstract:

A drug with a antipsychotic risperidone can be analyzed by liquid chromatographic techniques (LC) using uv-

visible and flourosans detectors. However all developed methods based on LC are expensive, time consuming

due to pre-and post-column reaction, and also not very selective and sensitive.

In this planned work, preparation of micro sized composite risperidone-sensitive sensor, development of

prepared composite risperidone-sensitive electrodes, and investigation of suitability as a detector in flow-

injection analysis system are aimed. For this aim, risperidone-sensitive censor membrane was prepared by

coating composite cocktail on the surface of contact transducer in solid state. Risperidone-sensitive censor was

not constitute internal reference electrode or solution. The potensiometric performance of risperidone-sensitive

chemical censor (selectivity constant, liner working interval, detection limit, response time, pH working

interval, repeatability, lifetime, and time dependent potential decay) was determined using computer controlled

measurement system in static conditions.

Because micro sized sensors will be developed in the present project study proposed are composite

material, the fabrication of flow-through cells in nano-liter dead volume can be produced for the use as

detectors in LC of risperidone that could be efficiently determined.

(b) (b) Figure 1.The response and linearity to exhibits of the all solid-state membrane electrodeagainst 1x10-1-5x10-5

Mrisperidoneconcentration change. *The study was supported by The Scientific and Technological Research Council of Turkey, TUBITAK, project no. 114Z033


25

OR-24

Usability and Attenuation Performance of Titanium-Iron Oxide Mineral as Natural Filler for Composite Ionizing Electromagnetic Radiation Shielding

Ezgi Eren Belgin1, Gül Asiye Ayçık1, Ayşe Kalemtas2 1Mugla Sitki Kocman University, Faculty of Science, Department of Chemistry, Mugla, Turkey, [email protected]

2Bursa Technical University, Faculty of Natural Sciences, Architecture and Engineering, Department of Metallurgical and Materials Engineering, Bursa, Turkey

Abstract:

Appropriate shielding materials are used to protect human and environment from harmful effects of high energy ionizing radiation. In the present, generally aggregated concretes and/or lead are used as electromagnetic radiation shielding materials. Concrete is a heavy material and can only be used for stationary applications while lead is heavy, not flexible, has low chemical and mechanic stability and hard workable specifications. Lead is also ranked as number two on the U.S. Government's Top 100 Hazardous Substances Priority List, which means that lead (#2) poses a bigger risk to human health than mercury (#3), chloroform (#11), cyanide (#35) and asbestos (#94) [1]. As the technology develops usage and production of radiation sources increases and need of novel shielding materials for different application areas increases, too. Thus the studies about production of new shielding materials with more desirable properties than lead and developing properties of conventional shielding materials rise during the recent years.

In this study, natural mineral-polymer composites were produced and their electromagnetic radiation shielding effects were investigated. Ilmenite (natural mineral of titanium and iron oxide) was used as reinforcement material and isophytalitic polyester unsaturated resin was used as composite base. After production, ionizing radiation attenuation properties of the composites were investigated by using HPGe detector and shielding properties of the produced composites were compared with the conventional shielding materials. The composites showed about %30 of the attenuation properties of lead and 4-5 times greater attenuation properties from the composite base polyester for electromagnetic radiation with low-intermediate and high energy. Thus this non-toxic and light weight novel material could be an alternative for lead shieldings. This shield could be used for both stationary applications as reactor shielding and also mobile applications because of its light weight. Light weight and comfortable clothing shield materials could be produced for radiation workers by using this material. The results showed that this material can be effectively usable by ionising-radiation workers and by the comfort of general population.

References

1. USA Agency of Toxic Substances&Disease Registry, http://www.atsdr.cdc.gov/ spl.index.htm


http://www.atsdr.cdc.gov/SPL/index.html

26

OR-25

Synthesis of Some Natural Bromophenols Including Propane Derivatives* Çetin BAYRAK, Abdullah MENZEK

Department of Chemistry, Faculty of Science, Atatürk University, 25240 - Erzurum, Turkey Abstract: Natural bromophenols are frequently isolated from marina life. This and similar compounds to it have biological activities such as enzyme inhibition , cytotoxicity, anticancer, antioxidant and microbial activities.1

Vanillin was used as starting material, and their reactions with acetone and propanal were performed. In the reactions, OH group of vanillin was protected as OMe and OMOM (methoxymethyl). After products were purified, protected groups in the products were removed and natural bromophenols 5, 6, 7 and 8 were obtained.

Synthesized products from the reactions were purified by chromatographic methods and their structures were determined by spectroscopic methods. *This study is supported by a grant (Project Number: 113Z702) from TÜBİTAK.

References

1. a) D. Shi, J. Li, S. Guo, H. Su, X. Fan, Chin. J. Ocean Lim, 2009,27, 277–282. b) Paul S, Gupta M. Synth. Commun.,2005, 35, 213-222. c) H.T. Balaydın, İ. Gülçin, A. Menzek, S. Göksu, E. Şahin, J. Enzym. Inhib. Med. Chem.,2010, 25, 685-695. d) H.T. Balaydın, M. Şentürk, S. Göksu, A. Menzek,Eur. Med. Chem., 2012,54, 423-428.

27

OR-26

From “Dark to light”1-2 to Fluorescence Resonance Energy Transfer: Dual Activator TPE Donor Fused BODIPY Dyes with a Large Stokes Shift and High Quantum Yield

Esra Şen, Serdar Atılgan aDepartment of Chemistry, Suleyman Demirel University, 32000, Isparta, Turkey,

Fluorescent molecules, providing insights into the solutions of current challenges towards widespread applications and expanding the horizons of many processes with their judiciously designed architecture, is an attractive sub-discipline in the broader field of supramolecular chemistry. This is mostly due to its many potential medicinal and bioimaging applications as well as material science. Fluorescence resonance energy transfer (FRET),1 is the one attractive spectroscopic technique that is used in these supramolecular architectures. FRET is explained as a process which describes the energy transfer between excited state donor fluorophore and ground state acceptor fluorophore linked together by a non-conjugated spacer.

In this study, we are presenting a novel strategy combining the advantageous of aggregation induced emission (AIE) methodology with energy transfer systems to improve energy transfer efficiency and thus increase adaptability of energy transfer systems to different applications. The strategy developed in this work provides a more promising approach for making full use of energy transfer systems in both organic and aqueous media with one donor-acceptor interaction.

References

1. Su, D., Oh, J., Lee, S.-C., Lim, J.M., Sahu, S., Yu, X., Kim, D., Chang, Y.-T. (2014) Chemical Science, 5 (12), pp. 4812-4818

2. E Aydin, B Nisanci, M Acar, A Dastan, ÖA Bozdemir New Journal of Chemistry 39 (1), 548-554

28

OR-27

Synthesis of The Topoisomerase-I Inhibitors Isoindolo[2,1-B]-Isoquinolin-7(5h)-One and the Alkaloid Rosettacin Based on Aryl Radical Cyclization and N-Acyliminium Chemistry

Lahssen El blidi1, Adam Daich2, Yousef Al-Zeghayer1

1 Chemical Engineering Department, King Saud University, Riyadh, Saudi Arabia 2 Laboratoire de Chimie URCOM, INC3M CNRS-FR 3038, Université du Havre, France

[email protected] Camptothecin 1a and his analogues with lactone-free ring such as the alkaloid luotonin-A (2), rosettacin (3a), acuminatine (3b), and 22-hydroxyacuminatine (3c) belonging to the named aromathecin family (ART), act as a selective poison of DNA-Top1.1 Taking into account these biological considerations with high importance, many synthetic approaches including QSAR studies have been conducted over the last 10 years to provide these aromathecins including the Top1 poison rosettacin (3a).2

In connection with our project aimed at the synthesis of aromathecins, herein we present a short and effective approach for the synthesis of the topoisomerase-I inhibitors isoindolo[2,1-b]isoquinolin-7(5H)-one and the alkaloid rosettacin belonging to the aromathecin family. The key step of this sequence which resulted in the formation of five-membered ring was the aryl radical cyclization3 of enamides generated by using the N-acyliminium chemistry.

[1] (a) Pommier, Y. Chem. Rev. 2009, 109, 2894–2902. (b) Khadka, D. B.; Cho,W.-J. Bioorg. Med. Chem.2011, 19, 724–734; and the references therein. [2] Cinelli, M. A.; Morrell, A. E.; Dexheimer, T. S.; Agama, K.; Agrawal, S.; Pommier, Y.; Cushman, M. Bioorg. Med. Chem.2010, 18, 5535–5552. [3]Wakchaure, P. B.; Easwar, S.; Argade, N. P. Synthesis2009, 10, 1667–1672.

29

OR-28

Determination of Structural and Spectroscopic Properties of Methyl-4-bromo-2-chloropyrıdine-3-carboxylate Molecule using FT-IR and NMR Experimental Techniques

and DFT Quantum Chemical Calculations

Zuhre CALISIRa, Mustafa KURTa, Mehmet KARABACAKb, Ahmet ATACc

a Department of Physics, Ahi Evran University,TR-40100, Kırsehir, Turkey [email protected],[email protected]

b Department of Mechatronics Engineering, H.F.T. Technology Faculty, Celal Bayar University,TR-45400, Turgutlu, Manisa, Turkey,[email protected]

c Department of Physics, Celal Bayar University,TR-45100, Manisa, Turkey, [email protected]

Abstract: The theoretical and experimental vibrational spectra of methyl-4-bromo-2-chloropyridine-3-carboxylate molecule were studied. The geometrical parameters and vibrational wavenumbers of methyl-4-bromo-2-chloropyridine-3-carboxylate molecule were calculated using the density functional method (B3LYP with 6-311++G(d,p) basis set). For this molecule, theoretical calculations were performed by using Gaussview and GAUSSIAN09 package program on the personal computer. Fourier Transform Infrared (FT-IR) spectrum of the studied molecule was recorded in the solid phase. 1H and 13C NMR spectra were recorded in DMSO solution. As a conclusion, the calculation results were applied to the simulated infrared and NMR spectra of the title compound, with the observed spectra.



30

OR-30

New Approach to Convenient Synthesis of Disubstituted Tacrin Derivatives Makbule EKİZa,b, Ahmet TUTARb, Salih ÖKTENc

aDepartment of Chemistry,Faculty of Art and Science, Düzce University, TR-81620, Düzce bDepartment of Chemistry, Faculty of Art and Science,Sakarya University, TR-54187, Sakarya

cDepartment of Primary Education, Division of Science Education, Faculty of Education, Kırıkkale University,TR-71450, Kırıkkale

[email protected], [email protected] Abstract: Tacrine derivatives have received attention due to pharmacological properties. Tacrines have been used to cure for alzhemier disease for years. The aim of this study is described a convenient route for 5,7-disubstituted tacrine derivatives via substitution reactions. Cupper promoted reactions gave methoxy ve cyanide tacrine compounds. Several 5,7-disubstituted tacrines were obtanined by treatment of 5,7-dibomotacrine with n-BuLi followed by trapping with electrophile [Si(Me)3Cl, S2(Me)2,and DMF].

Figure 1.Synthesis of tacrine derivatives

*This study is supported by a grant (Project Number 2014-02-04-008 and 2014-50-02-025) from Scientific Research Projects Committeeof Sakarya University.

References

1. M.T. McKenna, G.R. Proctor, L.C. Young, A.L. Harvey, J.Med. Chem., 1997, 40, 3516-3523. 2. G.R. Proctor, A.L. Harvey, Cur. Med. Chem., 2000, 7, 295-302.


31

OR-31

Chitosan/Nanoclay/n-Eicosane Microcapsules with Heat Energy Storage Property Ebru Gença, Sennur Alay Aksoya, Kasım Aksoyb

aSüleyman Demirel University, Textile Engineering Department, Isparta, Turkey bDepartment of Electronics and Automation, Technical Sciences Vocational School, Süleyman Demirel University, TR-32260, Isparta,

Turkey [email protected]

Abstract Microencapsulated PCMsrefer to PCMs encapsulated in micron-sized shellto avoid the possible interaction between the PCM and matrix and the PCM leakage. Paraffins like n-eicosane, n-octadecane, n-hexadecane are common PCMs used as the core material of microcapsules because of their appropriate phase transition temperature, large latent heat of fusion, and chemical stability (1). This study focuses on the preparation of microencapsulated phase change materials (MEPCMs), consisting of n-eicosane core within a chitosan/nano clay shell, using a complex coacervation method. The MEPCMs were prepared using two different weight ratios of chitosan/nan clay that are 1:1 and 1:1.5. The effects of the type ofthe surfactant on the encapsulation characteristics and thermal properties of the MEPCMs have been investigated. The analysis results show that the MEPCMs were prepared successfully. The thermal characteristics of MEPCMs prepared with various ratios by surfactant type. When the surfactant Span 80 was used the heat of melting of MEPCMs was higher. The melting temperature and latent heat of the MEPCMs were in the range of 35.43-36.59 °C and 94.11-120.51 J/g, respectively. According to the optical microscopy analysis results, microcapsules were spherically shaped. Acknowledgement: This work was financially supported by the Süleyman Demirel University (Project No. 4288-YL1-15). References 1. C.Fangyu,Y. Bao, Applied Energy, 2014,113, 1512–1518.

32

OR-32

ab InitioStudy of Elastic, Electronic and Phonon Properties of SnNCa3and PNCa3Compounds

Mustafa ÖZDURANa and RaşitUMUCUa

aDepartment of Physics,Faculty of Art and Science, Ahi Evran University, Bağbaşı-TR-40200 Kırşehir, Turkey

The structural, elastic, electronic and phonon properties of SnNCa3 and PNCa3 compounds with a cubic

antiperovskitestructure are studied by employing an ab initio pseudopotential method and a linear-response

technique within a generalized gradient approximation (GGA) of the density-functional theory (DFT) scheme.

The calculated structural properties, lattice constants, bulk modulus and its pressure derivatives are in good

agreement with available experimental and theoretical results. The calculations of the elastic constants have

been used to calculate C11, C12, and C44 for SnNCa3 and PNCa3.

Thesecalculatedelasticconstantssatisfythemechanicalstabilitycriterion, andtheductility of SnNCa3 and PNCa3 is

predictedbyPugh’scriterion. The electronic band structures show that SnNCa3 compound has metallic character

while PNCa3 is direct band gap semiconductor. The phonon-dispersion curves and phonon total and partial

density of states based on the linear-response method have been investigated for both materials.Thephonon

spectra of SnNCa3 and PNCa3 indicatethatthesecompoundsare not dynamicallystable, as

thereareimaginaryphononfrequenciesalongthe M-R and G-X forSnNCa3 and PNCa3, respectively.

REFERENCES [1] K. Haddadi, A. Bouhemadou, L. Louail, Y. Medkour, Solid State Communications 149 619-624 (2009). [2] K. Haddadi, A. Bouhemadou, L. Louail, S. Maabed, D. Maouche, PhysicsLetters A, 373 1777–1781 (2009). [3] M. Bilal, I. Ahmad, S.J. Asadabadi, R. Ahmad, and M. Maqbool, Electron. Mater. Lett., 11 466-480 (2015). [4] P. R. Vansant, P.E. Van Camp, V.E. Van Doren, and J.L. Martins, Phys. Rev. B 57 7615 (1998).

33

OR-33 The Trace Elements (Selenium, Copper, Zink, Iron) Levels in Patients Sera Affected

by Bovine Ephemeral Fever Hikmet Ün1, Guzin Camkerten2, Ilker Camkerten3, Tekin Sahin4, Burcu M. Balkan5, Özcan Erel6,

1 Aksaray University, Faculty of Veterinary Medicine, Dept. of Virology, Aksaray- Turkey

2Aksaray University, Faculty of Veterinary Medicine, Dept. of Biochemistry, Aksaray-Turkey 3 Aksaray University, Faculty of Veterinary Medicine, Dept. of Internal Medicine, Aksaray- Turkey

4 Bingöl University, Faculty of Veterinary Medicine, Dept. of Internal Medicine, Bingol -Turkey 5Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Dept. of Biochemistry Burdur-Turkey

6Yıldırım Beyazıt University, Faculty of Health, Department of Biochemistry, Ankara- Turkey [email protected]

Abstract:

Bovine ephemeral fever (BEF) transmitted by vectors and observed seasonal, is a disease of cattle and buffalo. The disease is an arboviral infection that observed in the tropic and sub-tropic zone of Asia, Australia, Middle East and Africa. The epidemics occur due to excessive population growth of the culicine and anopheline biting flies. The agent is a virus carrying the same name which is located in the Rhabdoviridae family, genus Ephemerovirus.

It has got an economic importance due to the temporary or permanent loss of milk production during disease. The disease is characterized by high fever (40-41.5 ° C), muscle stiffness, incoordination, lameness, muscle tremors, severe respiratory distress oedema and swelling of the lymph nodes under the skin.

It is known to be characteristic changes in biochemical and haematologic parameters in the affected animals. Starting from this point, it was aimed to determine the serum levels of trace elements (Selenium, Copper, Zink, Iron) in this study. The trace element levels were determined in the control group consisted of healthy animals (n = 15) and patients (n = 17), and recovering from illness (n = 17) and results were compared with the control group.Compared with the control group, statistically significant differences in serum selenium and iron levels (p <0.01) were found.Results support thatconsideration of serum selenium and iron levels is important the identification of patients and also it is needed an application considering of selenium and iron preparations. Anahtar kelimeler : Bovine ephemeral fever, threeday sickness, trace elements (selenium, copper, zinc, iron).

References

1. R.A. Bowen; Rhabdoviridae,In: Fenner’sVeterinaryVirology, Editors: MacLachlan, N.J.,andDubovi, E., fourthedition, AcademicPress. 2011, 327-341. 2. M.F. Uren; Bovine ephemeral fever. Aust Vet J.1989, 66, 233-236. 3. T.D. George, D.H. Cyki, G.M. Mbinsurphy, C.K.Dimmock; Serological and biochemicalfactors in bovine ephemeral fever. Aust. J. Biol. Sci.1984, 37(5-6), 341-349. 4. T.D. George, M.F. Uren, P.L. Young, D. Hoffmann; The natural history ofephemeral fever of cattle. Bovine ephemeral fever andrelated rhabdoviruses: Proceedings of the 1st InternationalSymposium, Beijing, PRC, 25-27 August 1992. 1993, 13-19. 5. P.L. Young, P.B. Spradbrow; Clinicalresponse of cattle to experimental infection with bovineephemeral fever virus. Vet Rec.1990.126(4), 86-88. 6. M.F. Uren, T.D. George, G.M. Murphy; Studies on the pathogenesis of bovine ephemeralfever in

experimental cattle. III. Virological andbiochemical data. Vet Microbiol. 1992, 30(4), 297-307.

34

OR-34 Comparison of PhenolicCompounds in Commercial BeePollenandPollen Inside theHive

Yaşar GÜLMEZa, Ömer KAYIRb, Mahfuz ELMASTAŞb aGaziosmanpasaUniversity, Faculty of ScienceandArts, Department of Biology, Tokat, Turkey

bGaziosmanpasaUniversity, Faculty of ScienceandArts, Department of Chemistry, Tokat, Turkey

[email protected]

Abstract:

Pollenwhichis veryrich in functionalcompounds,is produced in themaleorgans of floweringplants. Honeybeescollect polen fromtheflowersandstore in honeycombandthenusefornourishment of theiroffspringandotherindividualsinside thehive. Phenoliccompoundsareknowntohavemanybiologicalactivitiessuch as anticancer, antioxidant, and anti-inflammatory (1,2). Recently a number of studieshavebeenperformedrelatedtophenoliccompoundcontent of beepollen (3,4). However, thealteration of functionalcompoundcontentbetweenthecommercialbee polen which is takenfromoutsidethehiveand polen that is stored in thehive has not beenstudied. Therefore, in thisstudytheflavonoidcompoundscafeicacid, kumaricacid, ferulicacid, rutin, cinnamicacid, naringenin,quercetin,andkaempferolwereanalyzedby HPLC-DADandcompared in samplesof commercialbee polen and polen stored inside thehive. Quercetin and naringenin were found the highest in pollen inside thehive, 10862,86 (mg/kg pollen)and 1271,55(mg/kg pollen) respectively on theotherhandquercetinwasthehighest in commercialbeepollen (5656,14)(mg/kg pollen). Thesedifferencesaresignificantstatistically (p<0.01). [1]. A. Šaric, T. Balog a, S. Sobocanec, B. Kušic, V. Šverko, G. Rusak, S. Likic, D. Bubalo, B. Pinto, D. Reali, T. Marotti,

FoodandChemicalToxicology47, (2009), 547–554. [2] A. Pascoal, S. Rodrigues, A. Teixeira, X. Feás, L. M. Estevinho, FoodandChemicalToxicology63, (2014), 233–239. [3] M. Morais, L. Moreira, X. Feás, L. M. Estevinho, FoodandChemicalToxicology49, (2011) 1096–1101. [4] C. Fanalia, L. Dugoa, A. Rocco, Journal of Chromatography A, 1313, (2013) 270– 274.


35

OR-35 Conductance and Thermodynamic Study of Cobalt (II), Nickel (II) and Copper (II)

Complexes with a New Schiff Base Derived from 1,8-Diaminonaphthalene

Taher Sh. Ababneha*, Taghreed M. A. Jazzazib, Tareq M. A. Al Shboula, Ziyad A. Tahac.

aDepartment of Chemistry and Chemical Technology, Faculty of Science, Tafila Technical University, Tafila, Jordan.

bDepartment of Chemistry, Faculty of Science, Yarmouk University, Irbid, Jordan.

cDepartment of Applied Chemical Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan.

*Corresponding author: [email protected]

Abstract:

The complexation reaction of Co2+, Ni2+ and Cu2+ ions with a new Schiff base derived from 1,8-diaminonaphthalene has been studied conductometrically in DMSO at temperatures of 298, 303, 308 and 313 K. The stability constants of the resulting Schiff base complexes were determined indicating that the Ni2+ complex is more stable than the Co and Cu complexes. The enthalpy and entropy of the complexation reaction were determined from the temperature dependence of the complexation constants and the TΔS°-ΔH° plot shows a good linear correlation, indicating the existence of entropy-enthalpy compensation in the metal ion-Schiff base complexation reactions.


36

OR-36 Calcination of Galvaniz Ash andInvestigation of It’s Resolution in Acid Leaching

Solutions* Harun YILMAZa

Technical Sciences Vocational School, Suleyman Demirel University, Isparta, Turkey,

Abstract:

In this study, the optimum leaching conditions were examined in the hot-dip galvanized coated from a plant which has made studies for the evaluation of calcination of metallurgical ash hydrochloric acid solution. Galvanized methods used for assessing the ash; galvanized steel grinding of ash, at 373, 473, 573, 673, 773, 873, 973, 1073, 1173, 1273 and 1373 K temperature in kalsinanasyo the resolution was investigated in hydrochloric acid. At the end of these experiments, suitable acid concentration, dissolving time and temperature are determined.

References

1. SÖNMEZ, M. Ş., AÇMA E., "Galvaniz Tesislerinde Oluşan Sıvı Atıkların Metalürjik Olarak Değerlendirilmesi",Tr.J. Engin Environ Science 24(2000), 53-68, TÜBİTAK.

2. www.galvanizeit.org.publications/specgalv/MA.9htm. 3. SHREIR, L, L., "Zinc Coating Corrosion Control", 2hd Edition, NewnesButterwortths Vol. II, 1976. 4. J.N POMEROY AND J.E CROWLEY "Sources and Recovery of Scrap", Zinc.The Chemice Techonology of Metal İt's

Alloys and Compounds, ReinholdPub,N.Y., 1959. 5. ŞAHİN, CİNAR, F., DERİN, B., YÜCEL, O., "Chloride Removal From ZincAsh", Scandinavian Journal of Metallurgy, Volume

29, Issue 5 2000, Pages224-230.

http://www.galvanizeit.org.publications/specgalv/MA.9htm

37

OR-37 Electronic, Elastic, Thermodynamic and Phonon Properties of LaCd and LaCoOR-15

Compounds in the B2 Phase

Osman Örnek1, Nihat Arıkan2, Şule Uğur3 and Gökay Uğur3

1Ahi Evran Üniversitesi, Mühendislik-Mimarlık Fakültesi, Metelurji ve Malzeme Mühendisliği Bölümü,

40100 Kırşehir-Türkiye

2Ahi Evran Üniversitesi, Eğitim Fakültesi, İlköğretim Bölümü 40100 Kırşehir-Türkiye 3Gazi Üniversitesi, Fen Fakültesi, Fizik Bölümü, Teknikokullar, 06500 Ankara-Türkiye

Abstract

The first-principles calculations have been performed to study the structural, elastic, electronic and phonon

properties of cubicLaCd andLaCo compounds in the B2 phase. The optimized lattice constants, bulk

modulus and its pressure derivative, elastic constants are evaluated and compared with available data.

Electronic band structures and total and partial densities of states (DOS) have been derived for LaCd and LaCo

compounds.The electronic band structures show metallic character; the conductivity is mostly governed by La

5d and Cd 4d states for LaCd and Co-3d statesfor LaCo.Phonon-dispersion curves have been obtained using the

firstprinciple linear-response approach of the density-functional perturbation theory.The specific heat capacity

at a constant volume CV of LaCd and LaCocompounds are calculated and discussed.

38

OR-38 Kendiliğinden Yerleşen Betonda Hidratasyon Isısı Azaltıcı KimyasalKatkının Dayanıma

Olan Etkisi

İlker Kalkan, İlhami Demir, Ali Payidar Akgüngör, Özer Sevim

Kırıkkale Üniversitesi, Mühendislik Fakültesi, İnşaat Mühendisliği, Yahşihan, Kırıkkale, Türkiye Özet: Kendiliğinden yerleşen beton (KYB) özellikle hazır-beton sektörü, onarım güçlendirme işleri ve prefabrik inşaat sektörü başta olmak

üzere yapıların beton ile ilgili tümdallarında giderek daha fazla uygulama alanı bulmaktadır. Vibratör gerektirmeden yerleşmesi,

yüksek dayanım özelliği gibi nedenlerle yüksek performanslı beton üretimine olanak vermektedir.

Günümüzde en çok kullanılan özel beton çeşitlerinden biri kendiliğinden yerleşen betondur. Kendiliğinden yerleşen betonun

davranış özelliklerini bilmek için öncelikle kendiliğinden yerleşen betonun (KYB) yapısının iyi analiz edilmesi gerekir. Bu nedenle de

KYB’nin fiziksel ve kimyasal yapısının, onu oluşturan yapı malzemelerinin ve bu malzemelerin birbirleriyle uyumlu çalışmalarının

bilinmesi gerekir.

Bu çalışmada hidratasyon ısısı azaltıcı katkının kendiliğinden yerleşen beton (KYB) karışımların taze haldeki özellikleri ile yarmada

çekme dayanımı ve basınç dayanımı irdelenmiştir.

Anahatar Kelimeler: Kendiliğinden Yerleşen Beton, Hidratasyon Isısı Azaltıcı Kimyasal Katkı, Eğilme ve Basınç Dayanımı

39

OR-39 Anions Content of Wild Grown Edible Mushrooms Species in Ordu Region, Turkey

İbrahim TÜRKEKULa, ÖmerIŞILDAKb aGaziosmanpasaÜniversity, Faculty of Science and Education, Department of Chemistry, Tokat, Turkey

aGaziosmanpasaÜniversity, Faculty of Science and Education, Department of Biology, Tokat, Turkey

[email protected]

Abstract:

Ten different species of wild grown edible mushrooms Lactariuspiperatus, Lactariurvolemus,

Hydnumrepandum, Ramariaflava, Amanita vaginata, Amanita caesarea, Macrolepiota procea,

Mrasmiusoreades, Lepistanuda, Boletus edulisgrowing in the Ordu region, Turkey were analyzed used ion

chromatography with conductivity detector for their anions (fluoride, chloride, bromide, nitrite, nitrate, sulfate,

chlorate, phosphate, chromate and oxalate) levels. The results showed that the concentrations of fluoride and

bromidein all mushroom samples were below their limit of detection. Nitrite was found to be the lowest

abundantion, while the most abundant ion was sulfate in all the mushroom samples studied.

Chromatographic separation was performed inF, Cl−, Br−, NO2−, NO3

−, SO42−, PO4

3−, ClO3−, CrO4

2- and C2O42−

ionsat room temperature by using Ion Pac AS 9-HC anion exchangecolumn.Retention times of the inorganic

anions in standard solutions eluted between 3.34 and 18.29 min as shown in chromatograms. In all cases the

retention order F‒< CrO42−< Cl−< NO2

−< Br-< CIO3-< NO3

−< PO43−< SO4

2−< C2O42− typical was

observed.Calibration curves were obtained in the 1x10-1 – 1x10-5 mg/mL concentration range for.

Keywords: Wild edible mushroom, Ion chromatography, Turkey


40

OR-40 ICG-conjugated Magnetic Graphene Oxide for Dual Photothermal and Photodynamic

Therapy

Nuran Isıklana, Ismail Ocsoyb,cand Nalan Özdemird

aDepartment of Chemistry, Faculty of Science and Arts, Kırıkkale University, Kırıkkale, 7100Turkey bDepartment of Analytical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri, 38039 Turkey

cNanotechnology Research Center (ERNAM), Erciyes University, Kayseri, 38039 Turkey dDepartment of Chemistry, Faculty of Science, Erciyes University, Kayseri, 38039 Turkey

Abstract: Aptamer-functionalized magnetic graphene oxide conjugates loaded with indocyanine green (ICG) dye, or Apt@ICG@mGO, have been successfully developed for dual-targeted photothermal and photodynamic therapy. In this system, ICG, a near-infrared (NIR) dye, serves as both photothermal and photodynamic agent. It is immobilized on the surface of mGO via a physical interaction called“π-π stacking”. The mGO is utilized as a platform for aptamer and ICG dye conjugation, as well as a photothermal agent. The magnetic property of mGO is also used for separation of Apt@ICG@mGO conjugates from the reaction medium. Aptamer sgc8 acts as a targeting ligand to selectively and specifically bind to a protein on the membrane of cancer cell line CCRF-CEM. After the aptamer- functionalized ICG@mGO conjugates are incubated with target CEM cells at 37 °C for 2 hours, they are internalized into cells via endocytosis. More significantly, we demonstrated that the Apt@ICG@mGO conjugates produce heat for photothermal therapy (PTT) and singlet oxygen for photodynamic therapy (PDT) upon NIR laser irradiation at 808 nm. Thus, remarkably efficient cancer cell destruction is achieved in a short period of time.

Figure 1.Schematic illustration of Apt@ICG@mGO cancer cell interaction for PTT and PDT.

References

1. S. P. Sherlock, S. M. Tabakman, L. Xie and H. Dai; ACS Nano, 2011, 5, 1505–1512. 2. M. Zheng, C. Yue, Y. Ma, P. Gong, P. Zhao, C.Zheng, Z. Sheng, P. Zhang, Z. Wang and L. Cai;ACS Nano.2013, 7, 2056–2067.

41

OR-41 Comparison of Photo Physical Properties of 7-diethylamino-3-thenoyl coumarin and 7-

diethylamino coumarin Dr. Sanjay Kumar

Department of Physics, Rajdhani College, Delhi University, Raja Garden, New Delhi – 110015, India., E-mail:

[email protected].

Abstract The photo physical properties like ground state and first excited singlet state dipole moment etc. of 7-diethylamino-3-thenoyl coumarin and 7-diethylamino coumarin were compared. The effect of substituent at position 3 is also discussed in terms of the photophysical parameters. The study is carried out in various polar and non-polar solvents at room temperature using fluorescence and absorption technique. The solvent effect on photophysical behavior of these compounds showed that stokes shift increases with the polarity of solvents. The first excited singlet state dipole moment and ground state dipole moment were calculated using Bakhshiev, Kawski-Chamma-Viallet and Reichardt-Dimroth equations and were compared for both the coumarin studied. In boththe cases the dipole moments were found to be higher in the excited singlet state than in the ground state indicating a substantial redistribution of Π-electron density in the excited state. The angle between the first excited singlet state and ground state dipole moment is also calculated.The red shift of the absorption and fluorescence emission bands, observed for both the coumarin studied upon increasing the solvent polarity indicating that the electronic transitions were Π → Π* nature.Solvatochromic models such as Kamlet-Taft and Catalans 3P were used to correlate the solvatochromic shift in different polar and non-polar solvents with linear solvation energy relationship. Keywords :Coumarin, Solvent effects, Absorption spectra, Emission spectra, Excited singlet state dipole moment, Ground state dipole moment, Solvatochromism, Linear solvation energy.


42

OR-42 Synthesis and Solid State Self-assembly of Thiosemicarbazones Highlighting Their

Potential in Crystal Engineering Muhammad Moazzam NASEER

Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan Abstract: Urea and thiourea occupy a prominant place in crystal engineering and their applications in this field have increased dramatically over the past few years [1, 2]. However, their analogs namely N-imino thioureas/thiosemicarbazones, that can be more interesting with respect to crystal engineering applications due to the presence of additional N-imino moiety, could not get the attention they deserve [3]. This additional N-imino moiety not only freezes the conformation around thiourea moiety through intramolecular hydrogen bonding, but also increases acidity of neighbouring NH protons making it better H-bond donor. Due to this reason, the thiosemicarbazones should generally show preference forcis, trans conformation as compared to both the trans-trans and cis-trans-geometries observed for thioureas (Figure 1). This particular conformation in turn should be ideal for the formation of a dimeric

hydrogen-bonded {···H–N–C=S}2 synthon as the building block in their networks/assemblies.

To highlight this observation and their significance in this field, a variety of thiosemicarbazones have been designed, synthesized and crystallographically characterized in order to see the preference of cis, trans conformation and robustness of the

thioamide dimer synthon in the solid state. In a lmost all the studied compounds, thioamide dimer {···H–N–C=S}2

synthon as the building block is observed, indicating a much larger role of this class of compounds as a design element in crystal engineering than anticipated so far. Furthermore, thioamide-thioamide stacking (a novel interaction) and carbon bonding is also observed in the solid state structures of these compounds.

Figure 1. The most likely conformation of thiosemicarbazones

References

1. J. W. Steed, Chem. Soc. Rev. 2010, 39, 3686. 2. R. Custelcean, Chem Commun, 2008, 295. 3. R.Jawaria, M.Hussain, Z.Shafiq, H. B.Ahmad, M. N.Tahir, H. A.Shad, M. M. Naseer, CrystEngComm, 2015, 17, 2553.

43

OR-43 Synthesis of the Efficient Palladium Catalysts for the Cross-coupling Reactionsand

Hydrogenation by the Direct Loading of Inorganic Supports Using Stable Pd(0) Source*

Viacheslav I. SOKOLOV, Natalya V. ABRAMOVA Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia

([email protected]) Abstract: Palladium catalysts of type 1 have been prepared by loading Pd nanoparticles on the carbon nanotubes, SWNT or MWNT, by means of the direct heterogeneous reaction between the nanocarbon support and palladium(0) complex Pd2(dba)3(dba – dibenzylideneacetone) dissolved in benzene or chloroform. This catalyst is very active in hydrogenation of the triple and double carbon-carbon bonds and shows the high activity in the reactions of forming the novel C-C bonds such as Heck and Suzuki reactions. The detailed description of the experimental procedure can be found in the reference [1]. The same protocol appeared to be applicable to nanodiamonds (DND), graphene, and superparamagnetic double saltsPd-LDH@Fe3O4 [2, 3]. Some results are shown below. Catalyst of type 2 has been obtained starting from hydroxy-SWNT modified with enantiomeric amino acids with further application of the above-mentioned procedure of palladation.

Pd/graphenePd-LDH@Fe3O4

TEM microphotos

T,h t, °C yield, % T,h t, °C yield, % Suzuki 0.5 55 90 Suzuki 8 69 78

Heck 2 120 100 Heck 0.2 120 100

*This study is supported by grant 14-03-00467 from Russian Foundation for Basic Research

References

1. V. I. Sokolov, N. A. Bumagin, I. V. Anoshkin, E. G. Rakov, M. G. Vinogradov. Nanotechnologies in Russia, 2008, 3, № 9-10, 570-574. 2. А. Yu. Kryukov, S. Yu. Davydov, I. M. Izvol`skii, E. G. Rakov, N. V. Abramova, V. I. Sokolov, Mendeleev Commun.,2012, 22,237 - 241. 3. A. N. Ay, N. V. Abramova, D. Konuk, O. L. Lependina, V. I. Sokolov, B. Zümreoglu-Karan, Inorg. Chem. Commun., 2013,27, 64 – 68.

mailto:Pd-LDH@Fe3O4

44

OR-44 Synthesis of Methyl-Substituted Mono- and Di-Methoxy Conduritols*

Dilek KAPLAN, Latif KELEBEKLİ

Department of Chemistry, Ordu University, 52200 Ordu, Turkey Email: [email protected]

Cyclitols, highly hydroxylated cycloalkanes, are important compounds as they can be potentially used as glycosidase inhibitors as well as in the chemotherapeutic applications against diabetes,cancer, and viral infections.1 General compounds such as inositols, quercitols, carbasugars, or the families of gabosines 2, pericosines 3 and conduritols 1 belong to the family of cyclitols.2Interest in conduritols and their analogues have been amplified due to synthetic challenge and presence of a variety of biological activities.2,3 Moreover, the conduritols and their derivatives, in particular methoxy-derivatives of conduritols, continue to attract the attention of organic chemists also as synthetic intermediates in the preparation of cyclitols and pseudo-sugars.

Stereoselective synthesis of methyl-substitue methoxy-conduritols was developed starting frommetyl-benzoquinone. After bromination reaction of metyl-benzoquinone, the diketone in compound was selectively reducted with NaBH4.To obtain concound 4, acetylation with AcCl and then hydrolysis of the acetate groups furnished the desired compound.The structures of all of compounds obtained were identified by NMR spectra. *This study is supported by a grant (Project Number: TF-1451) from Scientific Research Projects Committeeof Ordu University. References

1. J. Duchek, D. R. Adams, T. Hudlicky; Chem. Rev. 2011, 111, 4223-4258. 2.O. Arjona, A. M. Gomez, J. C. Lopez, J. Plumet; Chem. Rev. 2007, 107, 1919-2036.

3. J. Plumet, A. M. Gomez, J. C. Lopez; Min. Rev. Org. Chem. 2007, 4, 201-216.

mailto:Email:%[email protected]

45

OR-45 Structure Activity Relationship Studies of Novel Quinoline Derivatives as Anticancer

Agents * Salih ÖKTENa, Osman Çakmakb, Şaban Tekinc

aDepartment of Primary Education, Division of Science Education, Faculty of Education, Kırıkkale University,TR-71450,

Kırıkkale,Turkey bDepartment of Chemistry, Faculty of Art and Science,Yıldız Technical University,TR-34210, Davutpaşa, İstanbul, TURKEY

cInstitution of Gene Engineering and Biotechnology, Tübitak MAM, TR-41470, Gebze, Kocaeli, TURKEY

Abstract: A series of quinoline derivatives were identified as novel and potent inhibitors of proliferation of cancer cell lines. Various analogues were synthesized and confirmed as inhibitors. The structure activity relationship (SAR) suggested that methoxy and hydroxy substituted quinolines have antiproliferative activity. Though 6,8-dibromo-1,2,3,4-tetrahydroquinoline has high antiproliferative impact, aromatizated form (6,8-dibromoquinoline) did not show anticancer activity. Substitution and coupling reactions was applied to 6,8-dibromoquinoline to get various quinoline derivatives. After that, anticancer activities of these derivatives were screened by using Eliza BrdU Cell Proliferation assay. Some of 6,8-disubstituted quinolines showed antiproliferative activity and apoptotic effect. In conclusion, electron donating substituents such as methoxy, hydroxy and phenyl contributed to quinoline nucleus to show anticancer activity.

Scheme1

*This study is supported by a grant (Project Number: 112T394) fromScientific and Technological Research Council of Turkey (TÜBİTAK).

References

1. S. Ökten, O. Çakmak, R. Erenler, Ş. Tekin, Ö. Yüce, Turk J Chem,2013, 37(6), 896-908. 2. A. Sahin, O.Cakmak, I.Demirtas, S. Ökten, A.Tutar, Tetrahedron,2008,64, 10068-10074. 3. S.Ökten, O.Çakmak, Ş.Tekin, T. K. Köprülü, B.Keskin, A.Saddiqa, S.Duman, M.Çınar, Med. Chem.

Res., 2015. Submited to journal.

46

OR-46 The Investigation Of Menthol’s Bioactivity In Blood As Theoritical By Using DFT

(Density Functional Theory) Faik GÖKALPa

aDepartment of Primary Education, Division of Science Education, Faculty of Education, Kırıkkale University,TR-71450,

Kırıkkale,Turkey

Abstract

Mints are used tradational medicine for hundred years by humankind. The important constitiuent of mint,

menthol,is especially in blood is eager to give reaction as an antioksidan. To understand menthol’s bioactivity

in body, some thermodynamical values (gibbs free energy, dipol moment HOMO, LUMO and the difference

between HOMO, LUMO) of menthol are measured by using DFT. Menthol dissolves in blood easily, reacts as

antioksidant and it is more stable than in gas form. So,It is so stable as protecting from radicalic attracts.

References

1. S. Chand, N.K. Patra, M. Anwar, D.D.Patra;Proc.Indian Natl.Sci.Acad., 2004, 3, 269-297.

2. ,A.L.Rozza, F.M.Faria, .R.S.Brito, C.H.Pellizzon;Antioxidant and Anti-Inflammatory Activities, Plos

One, 2014, (9),1.

3. M.A.Ha, G.J.Smith, J.A.Cichocki, L.Fan, Y.S.Liu, A.I.Caceres, S.E.Jordt, J.B.Morri;Plos One,2015, |

DOI:10.1371/journal.pone.0117128.

47

OR-47 Use of Supramolecular Solvents for Liquid Phase Microextraction of Gold(III) from

Environmental Sampled

aErkanYilmaz, Mustafa Soylak

aErciyes University, Faculty of Sciences, Department of Chemistry, 38039- Kayseri-Turkey

Abstract: Supramolecular solvent based liquid–liquid microextraction (Ss-LLME) is a new microextraction

technique that has been developed for the preconcentration and separation of organic and inorganic species [1, 2]. Supramolecular solvents have a large interaction area and can interact with analytes through hydrophobic interactions, dispersion forces and hydrogen bonding. The interaction areas in supramolecular assemblies provide a high extraction efficiency and a short extraction time. The preparation of supramolecular solvents at room temperature using the conventional, cheap and harmless chemicals is the most important advantage of their application [3-4].

This work presents a rapid, simple, sensitive method for the preconcentration of gold in environmental samples using Supramolecular solvent microextraction, which is subsequently detected by microsampling flame atomic absorption spectrometry (FAAS). In the proposed method, 1,3,4-Thiadiazole-2,5-dithiol was used as a complexing agent to obtain a hydrophobic complex. The important parameters affecting the microextraction efficiency, such as the pH, type and volume of supramolecular solvent, amount of complexing agent, ultrasonication and centrifuge time, and sample volume, were investigated. The limit of detection (LOD), enhancement factor (EF) and relative standard deviation (RSD) of the method were 1.5 µg L -1, 51 and 4.2 %, respectively. The accuracy of the method was checked by addition-recovery tests and the analysis of CDN-GS-3D Gold Ore certified reference material. The method was successfully applied for the determination of gold in environmental samples. References 1. E. Yilmaz , M. Soylak, Talanta, 2014, 126, 191–195. 2. Q. Yang, W. Su, X. Y. Jiang, X. Q. Chen, Int. J. Environ. Anal. Chem., 2014, 94, 812–821. 3. F. Rezaei, Y. Yamini, M. Moradi, B. Daraei, Anal. Chim. Acta, 2013, 804, 135–142. 4. A. Moral, M. D. Sicilia, S. Rubio, Anal. Chim. Acta, 2009, 650, 207–213.

48

OR-48 Facile and Large Scale Synthesis of Graphene

Tugay ÜSTÜNa, Havva Tutar KAHRAMANb, Ahmet AVCIa, Erol PEHLİVANb

aDepartment of Mechanical Engineering, Faculty of Engineering,Selçuk University, TR-42100, Konya, Turkey bDepartment of Chemistry Engineering,Faculty of Engineering, Selçuk University, TR-42100, Konya, Turkey

Abstract:

Graphene is two-dimensional structure of graphite and due to its great mechanical, electronic, optical and thermal properties it is of great interest among other nanomaterials[1]. Sensors, catalysts, electronics and applications made from graphene are available in many fields[2]. Among graphene production methods hummer method is generally preferred because of its cheapness and easiness[3]. In this study hummer method was also utilized in order to produce graphene. KMnO4was added to H2SO4-graphitesolution then mixed with HCl acid solution.After the washing process graphene oxide (GO) was obtained. GO nanoparticles were converted into the graphene using reflux method by hyrdroquinone solution. The difference between GO and the graphene nanoparticles are determined by SEM, XRD and FTIR characterization methods.

References

1. J. Chen, B. Yao, C. Li, G. Shi, Carbon, 64, 2013, 225-229. 2. L. Sun, B. Fugetsu, Materials Letters, 109, 2013, 207-210. 3. H. Bai, C. Lİ, G. Shi, Adv. Materials, 23(9), 2011, 1089-115.

49

OR-49 Fabrication of Thermo-regulated PAN/Myristic asid (MA) Nanofibers by the

Electrospinning Process M.Selda TÖZÜMa, Sena DEMİRBAĞa, Kasım AKSOYb

aDepartment of Textile Engineering,Süleyman Demirel University, Isparta, Turkey bDepartment of Electronics and Automation,Technical Sciences Vocational School, Süleyman Demirel University, Isparta, Turkey

[email protected] Abstract: Phase change materials (PCMs) are latent heat energy storage materials and very attractive for their applications in thermal energy storage and temperature control. Their temperature can stay nearly constant during phase change process (1). In general, according to their phase change states, there are mainly threetypes of PCMs, namely, solid–solid, solid–liquid, andliquid–gas PCMs (2). Amongthese PCMs, the most commonly used PCMs are the solid–solid and the solid–liquid type PCMs. However, their application is also limited because of easy leakage during using. Therefore, a kind of novel compound PCM, the so-called shape-stabilized PCM has attracted the interests of the researchers to make solid–liquid PCM turn into a solid–solid PCM. Shape-stabilized PCMs can remain in solid state even when the working materials change from solid to liquid. The supporting materials of the shape-stabilized PCMs confine the melted phase change material from leaking and keep the whole system in the solid state during the melting or solidifying processes (2,3). In recent years, PCM/polymer composite nanofibers as a novel kind shape-stabilized PCM, have been developed via electrospinning technique (2,4,5).In this study, thermo-regulated nanofibers containing phase change material was preparedusing the electrospinning process. In the study, myristic asid (MA) and polyacrylonitrile (PAN) polymer were used as phase change material and supporting material, respectively. 10 % w/w PAN /DMF (N,N-dimethylformamide) solutions were prepared and different amount of MA was added to this solution. Thermal energy storage properties, morphology and chemical structure of the PAN/MA composite nanofibers were characterized by differential scanning calorimetry (DSC),scanning electron microscopy (SEM) and Fourier transform IR (FT-IR) spectroscopy methods, respectively.

References

1. Feng, L., Zheng, J., Yang, H., Guo, Y., Li, W., Li, X., 2011. Solar Energy Materials and Solar Cells,95(2), 644–

650. 2. Li Zhang, Jing Guo, Xiangkang You, Yuanfa Liu, Lijun Yang,Bo Zhang, Sen Zhang and Yumei Gong, 2015.

High Performance Polymers, 1–8. 3. Wang, C., Feng, L., Li, W., Zheng, J., Tian, W., Li, X., 2012. Solar Energy Materials and Solar Cells, 105, 21–

26. 4. C. Chen, L. Wang, Y. Huang, Materials Letters, 2008, 62(20), 3515–3517. 5. C. Chen, L. Wang, Y. Huang, 2009, Materials Letters, 63(5), 569–571.

50

OR-50 Kendiliğinden Yerleşen Betonda Piriz Hızlandırıcı KimyasalKatkının Dayanıma Olan Etkisi

Ali Payidar Akgüngör, Özer Sevim,İlhami Demir,İlker Kalkan

Kırıkkale Üniversitesi, Mühendislik Fakültesi, İnşaat Mühendisliği, Yahşihan, Kırıkkale, Türkiye Özet: Günümüzde en çok kullanılan özel beton çeşitlerinden biri kendiliğinden yerleşen betondur. Kendiliğinden yerleşen betonun davranış özelliklerini bilmek için öncelikle kendiliğinden yerleşen betonun (KYB) yapısının iyi analiz edilmesi gerekir. Bu nedenle de KYB’nin fiziksel ve kimyasal yapısının, onu oluşturan yapı malzemelerinin ve bu malzemelerin birbirleriyle uyumlu çalışmalarının bilinmesi gerekir. Son yıllarda düşük su/bağlayıcı oranına sahip ve çatlak oluşumuna daha eğilimli yüksek kalitedeki betonların üretimi ile birlikte durabilite konusunda çatlak oluşumunun oynadığı zararlı rol, rötre ve erken yaş çatlakları konusuna duyulan ilginin yeniden artmasına yol açmıştır. KYB özellikle eğimli betonlarda sorunlu olabilmektedir bu soruna çözüm olarak piriz hızlandırıcı katkı maddeleri kullanılabilr. Bu amaçla;priz hızlandırıcı katkının kendiliğinden yerleşen beton (KYB) karışımların taze haldeki özellikleri ile yarmada çekme dayanımı ve basınç dayanımlarına etkisi incelenmiştir. İnceleme neticesinde 2 günlük dayanımları arttırırken 28 günde dayanıma katkı sağlamadığı gözlemlenmiştir. Priz hızlandırıcı KYB nin taze beton özelliklerine belirgin bir katkı sağlamamıştır.

Anahatar Kelimeler: Kendiliğinden Yerleşen Beton, Priz hızlandırıcı, Eğilme ve Basınç Dayanımı

51

OR-51 Density Functional Theory and ab initio Hartree-Fock Calculations of

Molecular Structure and Conformational Properties of 4-X-Phenylboronic acid derivatives ( X = F, Cl, Br ).

Güventürk UĞURLU

Department of Physics,Faculty of Art and Science, Kafkas University, TR-36100, Kars, Turkey

Abstract:

Boronic acid and its derivatives have been extensively studied owing to their good performance as pharmaceutical agents [1]. Conformational analysis and the molecular structures of 4-phenylboronic acid and its derivatives have been theoretically studied. The theoretical calculations were carried out using ab-initio Hartree Fock (HF) and density functional theory (DFT: B3LYP) methods with the 6-31++G (d, p) and 6-311++G (d, p) basis sets and the GAUSSIAN 09 program package. The structure parameters, the electronic energy, the dipole moment, the highest occupied molecular orbital (HOMO) energy and the lowest unoccupied molecular orbital (LUMO) energy were calculated, discussed andcompared to the corresponding values for related compounds.

References

1. J. M. Silla, R. A. Cormanich, R. Rittner and M. P. Freitas, Beilstein J. Org. Chem. 2013, 9, 1127–1134

52

OR-52 Electronic Structure, Elastic and Phonon Properties of Rh3La Compound: An ab

initioStudy

Nihat Arıkan1, Osman Örnek2, Şule Uğur3 and Gökay Uğur3

1Ahi Evran Üniversitesi, Eğitim Fakültesi, İlköğretim Bölümü 40100 Kırşehir-Türkiye 2Ahi Evran Üniversitesi, Mühendislik-Mimarlık Fakültesi, Metelurji ve Malzeme Mühendisliği Bölümü,

40100 Kırşehir-Türkiye 3Gazi Üniversitesi, Fen Fakültesi, Fizik Bölümü, Teknikokullar, 06500 Ankara-Türkiye

Abstract

The structural,elastic, electronic and phonon properties of Rh3La compound within density functional theory

have been investigated. The calculated lattice constants for those compounds are in good agreement with the

available data.The elastic constants (C11, C12 and C44) in L12 phase for Rh3La compound are calculated using

the energy-strain method.These calculated elastic constants satisfy the mechanical stability criterion and the

ductility of Rh3La is predicted by Pugh’s criterion. The present electronic band structure calculations predict

that the L12-Rh3La compound is metallic characters. Phonon properties were obtained using the first-principle

linear-response approach of the density-functional perturbation theory.Finally specific heat at constant volume

versus temperature is calculated and discussed using the quasi harmonic approximation.

53

OR-53 Production of Heat Energy Storage PAN/PEG Nanofibers

Sena DEMİRBAĞa, Kasım AKSOY b, M.Selda TÖZÜMa

aDepartment of Textile Engineering,Süleyman Demirel University, Isparta, Turkey

bDepartment of Electronics and Automation, Technical Sciences Vocational School, Süleyman Demirel University, Isparta, Turkey

[email protected] Abstract: Recently, because of increasing energy use and decreasing energy sources,there are more and more interests in the research of renewable energy sources and materials on the globe [1]. One of the renewable energy resources is to use the phase change materials (PCMs) as thermal energy storage materials. PCMs have been applied in many different areas because they store or release a large amount of latent heat energy whenthey change their phase from one physical state to another. There is a risk of PCM leakages during using when the solid PCMs melt. Therefore, shape-stabilized PCMs or form stable PCMs have been developed in the last decade for their uniqueadvantages such as direct use without additional encapsulation and with cost effective. Recently, electrospinning technique has been used to fabricate shape-stabilized PCM/polymer composites nanofibers [2]. Inthis research, thermo-regulated polyacrylonitrile (PAN)/polyethylene glycol (PEG)-blended phase change nanofibers were preparedby means of electrospinning. PEG 600 and PEG1000 polymers were selected as the PCM and PANpolymer was used as the polymercarrier. PCMs were added into 10% dimethylformamide (DMF)/PAN solution andnanofibers with different mass ratios of PEG/PAN werefabricated via electrospinning. Morphology, thermo-regulatedproperties, and chemical structure of the PAN/PEG thermo-regulatednanofibers were studied by scanning electron microscopy (SEM), differential scanning calorimeter (DSC),and Fourier transform infrared spectrometer(FTIR), respectively. References: 1. C. Chen, L. Wang, Y. Huang , 2008, Materials Letters, 62, (20), 3515–3517. 2. C. Chen, L. Wang, Y. Huang, 2009,Materials Letters, 63(5), 569–571.

54

OR-54 Cost-Effective Graphene Coated Polyurethane Sponge for Oil/water Separation

Havva Tutar Kahraman1, Tugay Üstün2, Erol Pehlivan1, Ahmet Avcı2 1Department of Chemical Engineering, Selcuk University, 42079 Konya, Turkey

2Department of Mechanical Engineering, Selcuk University, 42079 Konya, Turkey E-mail address : [email protected]

Abstract: Oil/water separation is an important issue, not only for laboratory research but also for applicationsaiming to resolve industrial oily wastewater and oil-spill pollution problem, as well as environmental protection[1]. Through the increasing awareness of environmental protection and need for water treatmentand recycling, there is a growing request for technologies that can absorb, remove, and transfer oil spills ororganic contaminants from water [2].To alleviate this problem, various oil sorbent materials such asfoams [3–5], nanocomposites [6–7], and carbon nanotube materials[8],mesh filmshave been developed. However, these materials are usuallyrequiring cost consuming and complicated processes tofabricate, besides these points environmental and ecological risk of these materials in application remains unclear. Generation of functional materials that can remove oil from water by an energy-efficient way is highly desirable.Recently, novel materials with high oil absorption capacity haveattracted considerable interest in the field of oil-waterseparation. In this study, graphene coated sponges were fabricated by a facile method. A commercially available polyurethane sponge, a kind of porous and superhydrophilic structure with absorption capacity of both water and oils or organic solvents, was used as a substrate for graphene coating. This kind of sponge provide excellent substrates for the fabrication of oilabsorbents. However, it is usually hydrophilic, which makes it impractical for the selective and efficient removal of oils from water. Therefore, modifications should be done to change them from hydrophilic to hydrophobic nature. Firstly, hydrophobic graphene nanosheets were controllably anchored on the sponge skeletons to regulate the sponge’s characteristic from superhydrophilic to superhydrophobic [9]. In the next step, various classes of organic liquids were evaluated by the as-fabricated graphene-based sponges. Coated sponges show efficient absorption of not only oils, but also solvents such as ethanol and chloroform, requiring no further pretreatment. This graphene coated sponges could be used as a promising oil absorbent candidate for large-scale removal of organic contaminants from water, due to its superhydrophobicity and superoleophilicity.

References

[1]Z. Xue, Y. Cao, N. Liu, L. Feng, and L. Jiang; Journal of Materials Chemistry A, 2014, 2, 2445-2461. [2]B. Ge, Z. Zhang, X. Zhu, X. Men, X. Zhou, Q. Xue; Composites Science and Technology. 2014, 102, 100–105. [3] X.C. Gui, J.Q. Wei, K.L. Wang, A.Y. Cao, H.W. Zhu, Y. Jia; Advanced Materials. 2010, 22, 617–621. [4] D.P. Hashim, N.T. Narayanan, J. M. Romo-Herrera, D. A. Cullen, M.G. Hahm, P. Lezzi; Sci Rep.2012, 2, 363–370. [5] P. Calcagnile, D. Fragouli, I.S. Bayer, G.C. Anyfantis, L. Martiradonna, P.D. Cozzoli; ACS Nano.2012, 6, 5413–5419. [6] Y. Chu, Q.M. Pan; ACS Applied Material Interfaces. 2012, 4, 2420–2425. [7] S.Y. Tao, Y.C. Wang, Y.L. An; Journal of Material Chemistry. 2011, 21,11901–11907. [8] C. Lee, S. Baik; Carbon.2010, 48, 2192–2197. [9] D.D. Nguyen, N-H. Tai, S-B. Lee and W-S. Kuo; Energy and Environmental Science. 2012, 5, 7908-7913.


55

OR-55 Synthesis and Application of Nano- Metal Catalysts by Metal Vapor Method

Vagif AKHMEDOV, Dilgem TAGIYEV M.F.Nagiyev Institute of Catalysis and Inorganic Chemistry of the National Academy

of Sciences of Azerbaijan e-mail: [email protected]

Chemical materials in the nanometric range have attracted a great deal of interest due to their unusual properties that differ markedly from those of bulk systems. Owing to their special properties the nanostructured materials have found extensive applications in electronics, optics, energy storage, and catalysis. The nano-metal particles possessing high catalytic activity have a good potential for improving the efficiency, selectivity and productivity of chemical processes bringing the gap between theory and modeling as well as between heterogeneous, homogeneous and bio-catalytic approaches. The precise manipulation of individual metal particles at molecular level connected with the surface effect may lead to a new design of perspective catalysts.

Metal and metal oxide particles in the nanometric range can be synthesized by a number of techniques such as physical and chemical vapor deposition, plasma processing, electro-deposition, microwave-assisted methodsand by reduction of metal salts in the presence of different templates. We have developed metal vapor method (MVM) to synthesize nano-metal and metal-oxide particles of controlled size and compositions. In this talk the use of MVM-made nano-metal and metal-oxide particles as catalysts for activation of C=C, C-H, and C-C bonds in hydrocarbons will be illustrated.

The low temperature co-condensation of the metal vapors (MVM) such as Ni, Zr, Pd, Pt, Ru, Re, etc. with molecules like toluene or butadiene yields the “metal solutions” contained highly dispersed metal

particles. Interaction of the “metal solutions” with supports of different surface acidity and pore structures leads

to the formation of some novel composite materialscontaining highly dispersed metals. The results of physico-chemical analysis (thermal and hydrogen-induced desorption, SEM, X-RAY and ESR-spectroscopy) showed that the metal particles on these materials are mostly in the nano-sized range.

The described method has been explored for the creation of a new class of heterogeneous catalysts with superior activity for the oligomerizationof low olefins (C2-C3) and low temperature hydroconversionn-alkanes(C7-C16). It was shown that the activation C-H and C-C –bonds cleavageability of some outer layered nano-metals in alkanes could be comparable with activity of discrete complexes of these metals under homogeneous conditions. One of the most important advantages of prepared catalysts is their high stability.

The final content of reaction products depends mostly on the type of metal, chain length of n-alkane and pore morphology of supports. With this respect, zeolites with different pore sizes (ZSM-5, Y, ß, M-41) were used as a support in preparation of catalysts. If there are no shape restriction and diffusion limitation, high n-alkanes can undergo successive conversion into multi-branched intermediates before cracking leading to the synthesis of iso-alkanes of gasoline range, which are of utmost interest for production of eco-clean high octane fuels. On the other hand, as the support pores are getting smaller, the formation of bulkier multi-branched isomers will be restricted. Under these conditions of hydroconversion, the selectivity of less branched isomers high alkanes can be increased up to 85-90%, which is important to produce lubricant oils with good cold flow properties.

The results show thatthe low temperature catalytic activation of olefins and cleavage of carbon-hydrogen and carbon-carbon bonds in alkanes would be far more attractive from an economic standpoint for working out the efficient energy-saving and environmentally friendly technologies.


56

OR-56 Characterisation of Graphene Oxide/Poly(Acrylonitrile-Vinyl Acetate) Nanocomposites

Produced by Electrospinning Method*

Mustafa YAZICIa,d, İsmail TİYEKb,d, M. Hakkı ALMAc,d, Utkay DÖNMEZd,Behzat YILDIRIMd, İbrahim KARTERİd, Tufan SALANd, Serhan URUŞd,e, Şükrü KARATAŞd,f, M. Sabri ERSOYb

aDepartment of Elementary Education, Faculty of Education, Kahramanmaras Sutcu Imam University (KSU), TR-46100, Avsar Campus, Kahramanmaraş, Turkey

b Department of Textile Engineering, Faculty of Engineering and Architecture, KSU, Turkey

cDepartment of Forest Industrial Engineering, Faculty of Forestry, KSU, Turkey

dDepartment of Material Science and Engineering, KSU, Turkey eDepartment of Chemistry, Faculty of Science and Literature, KSU, Turkey

fDepartment of Physics, Faculty of Science and Literature, KSU, Turkey e-mail: [email protected]

Abstract: Graphene, a two dimensional monoatomic thick building block of a carbon allotrope, has emerged as an interesting material of the 21st century, and received world-wide attention due to its exceptional electrical, thermal, optical, and mechanical properties. Graphene oxide (GO), one of the other forms of graphene, is frequently obtained by the oxidation of graphite. The aim of this study was to define the appropriate production parameters for production of GO/PoliAcrylonitrile-Vinyl Acetate (AN-VAc) nanofiber based nanocomposite textile surfaces and to characterize some structural and physical properties of produced GO/P(AN-VAc) nanocomposite textile surfaces. Firstly, GO were produced by using improved Hummers method. Different ratios of produced GO were mixed in DMF by utrasonication and PAN-VAc polymers were solved in DMF. Then dispersed GO with different ratios (0, 1.5, 3, 4.5 and 6 wt.%) were added in P(AN-VAc) solution for preparing GO/P(AN-VAc) solutions in DMF. Nanocomposites were produced from GO/P(AN-VAc) solutions by electrospinning method with 24 kV and 14 cm distance of collector. Produced GO/P(AN-VAc) nanocomposites were investigated by FTIR, TGA, DSC, and SEM. The results of DSC showed that all of the nanocomposite samples exhibited endotermic peaks in a temperature range from 303°C to 307°C. On the other hand, TGA findings indicated that the addition of GO into P(AN-VAc) improved thermal properties of the nanocomposites and reduced the weight loss in a range of 6-9%. The FTIR spectra showed that new characteristic peak was not formed in GO/P(AN-VAc) nanocomposites. However, it was observed that some peaks shifted to lower wavenumber and the transmittance values of some peaks relatively changed. Finally, the morphological properties of nanocomposites will be investigated according to the SEM results. *This study is supported by a grant (Project Number: 114M527) from The Scientific and Technological Research Council of Turkey

(TUBİTAK)

References

1. L. Gan, S. Shang, C. W. M. Yuen, S. X. Jiang, N. M. Luo; Composites Part B: Engineering.2015, 69, 237-242. 2. Q. Wang, Y. Du, Q. Feng, F. Huang, K. Lu, J. Liu, Q. Wei; Journal of Applied Polymer Science.2013, 128, 1152-1157.


57

OR-57 Supercapacitor Electrode Materials of Novel Synthesized Polymer/Carbon Nanotube

Composite Materials* Murat ATESa, and Nesimi ULUDAGa

aDepartment of Chemistry,Faculty of Art and Science, Namik Kemal University, TR-59030, Tekirdag, Turkey Abstract: In this study, 3 novel comonomers based on Carbazole-EDOT skeleton were chemically synthesized and electropolymerized on glassy carbon electrode (GCE). Polymer/carbon nanotube composite materials were also synthesized as a supercapacitor electrode materials. These materials were comparatively measured as capacitance performances. Stability tests were also obtained for these 3 novel polymer and composite materials.

Scheme1.Electropolymerization mechanism of 3 different comonomers.

*This study is supported by a grant (Project Number: 110T791) from The Scientific and Technological Research Council of Turkey. References

1. M. Ates, N. Uludag, T. Karazehir, F. Arican, Ovidius University Annals of Chemistry,2012, 23, 63-71. 2. M. Ates, N. Uludag, T. Karazehir, F. Arican, J. Solid State Electrochem.,2013, 17(9), 2417-2427. 3. M. Ates, N. Uludag, T. Karazehir, F. Arican, J. Electrochem. Soc., 2013, 160(1), G46-G54.

58

OR-58 Linear Pentanuclear Nickel Complex with Pyrazine Modulated N,N’-di(pyrazin-2-

yl)pyridine-2,6-diamine Ligand Rayyat Huseyn Ismayilov,*a,b Fuad Famil Valiyev,aWen-Zhen Wang,b,cGene-Hsiang Lee,band Shie-Ming Peng*b

aOilGasScientificResearchProject Institute, SOCAR, Azerbaijan. bDepartment of Chemistry, National Taiwan University, Taipei, Taiwan, ROC.

cSchool of Chemistry and Chemical Engineering, Xi’an Shiyou University. E-mail:[email protected];[email protected]

Using pyrazine-modulated oligo-α-pyridylamido ligand, N,N’-di(pyrazin-2-yl)pyridine-2,6-diamine (H2dpzpda)linear pentanickel(II) extended metal atom chain (EMAC)Ni5(µ5-dpzpda)4Cl2 (1) was first synthesized and structurally characterized.Structure of 1is similar to those of [Ni5(µ5-tpda)4X2] (where X = Cl-, NCS- and tpda2- is a dianion of unmodulated H2tpda ligand), showingan EMAC structure with four deprotonated supporting ligandsdpzpda2- wrapped around the linear metal chain in a syn–synformas dianion helices, as seen in Fig. 1. Two chloride anions bond to the terminalmetal as axial ligands, and they are co-linear with the Ni5metal score chain.

Figure 1. Themolecular structure of [Ni5(µ5-dpzpda)4Cl2](1). Atoms are drawn at the 50%probability level. Hydrogen atoms are

omitted for clarity. A temperature dependent magnetic study of Ni5(µ5-dpzpda)4Cl2 (1) indicates the antiferromagnetic interaction between terminal

nickel ions. The curves of magnetic susceptibility and effective magnetic moment (eff) are very similar with curves in case of Ni5(µ5-tpda)4Cl2. However, the electrochemical behavior ofNi5(µ5-dpzpda)4Cl2 (1) is quite different with that of the unmodulated complex Ni5(µ5-tpda)4Cl2.It is well known that in the CV of Ni5(µ5-tpda)4Cl2 has observed only one oxidation wave at 0.65 V. But in CV of Ni5(µ5-dpzpda)4Cl2there are two reversible waves at Eo = +1.206 V and – 0.680 V. The difference in oxidation potentials of over 500 mv is very significant. The introduction of electron-withdrawing pyrazine rings to thespacer ligands retarded oxidation and stabilized of the complex.Considering the difficulties of synthesis of long chain ligands complexes with oligo-α-pyridylamido ligands, the long chain pyrazine-containing ligands are hopefully a new family to extend the EMAC complexes to much longer molecules.

mailto:%[email protected]


59

OR-59 Key Magnetic Intermediates in Mo-, W-, Re –Based Catalytic Systems for Olefins

Metathesis Reactions: Structure and Reactivity* Yadigar ABBASOVa, Etibar ISMAILOVa, Dilgam TAGIYEVb

aInstitute of Petrochemical Processes, Azerbaijan National Academy of Sciences, AZ1025, 30,Khojaly Aven.,Baku, Azerbaijan, e-mail: [email protected]

bInstitute of Catalysis and Inorganic Chemistry,Azerbaijan National Academy of Sciences, AZ1143, 29,Huseyn Cavid Aven.,Baku, Azerbaijan

Abstract:

Mo-, W-, Re- based Ziegler type systems have been studied as effective catalysts for metathesis reactions of olefins during the last more than 30 years. But to date information on the key intermediate complexes, particles, their structure and reactivity is very poor and not sufficient for understanding the nature of the catalytic activity of these systems. The absence of these data is primarily due to difficulty in isolation of intermediates in these systems by the methods for direct structural characterization. Therefore, most of studies are based on the use of optical and magnetic resonance methods, which allow to identify the intermediate particles in situ conditions, i.e. during the olefin metathesis reaction. But the absence of experimental results based on direct observation and simultaneous measurement of the kinetics for formation and destruction of intermediate particles using optical, magnetic resonance and reaction products, for example, by chromato-mass-spectrometric techniques during the olefin metathesis is one of the main reasons for the lack of the scientific progress in this important field of catalysis. The aim of this report is to present the results of combined in situ EMR/on line GC-MS studies for identification of magnetic complexes, particles, their structure, reactivity and participation as catalytically active centres in Ziegler type systems for metathesis of olefins based on mono-, bi- and hexa-nuclear Mo-, W-, Re -complexes and aluminium-organic compounds. *We are grateful to the Fund of Science Development administrated by the Council of Azerbaijan President for the support. References

1. A. Brückner; in In-Situ Characterization of Heterogeneous Catalysts,edited by J. A. Rodriguez, J. C. Hanson, P. F. Chupas, Wiley-VCH, Weinheim, Germany 2013, 11, 293-314.

2. E.H.Ismailov, M.J.Maharramov, Yu. A. Ganbarova, D.B. Tagiyev,M. I. Rustamov; 3rd International Congress on Operando Spectroscopy, Rostock, April 19–23, 2009.

3. E.H.Ismailov, D.B.Tagiev, N.M.Aliyeva;TAILored surfaces in Operando conditions: Structure and Reactivity,France, April 8-11, 2014.

60

OR-60 Determination Optimum B2O3, KCl and NaOHMolar Ratios in the Synthesis of Potassium

Borates A. SeyhunKIPCAKa, Merve GUNAL, Sibel ILA, Meral YILDIRIMa, MehmetB. PISKINbEmek MOROYDOR DERUNa,

aDepartment of Chemical Engineering,Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, TR-34210, Istanbul, Turkey

bDepartment of Bioengineering,Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, TR-34210, Istanbul, Turkey

Abstract: Borates are attention getting chemical compounds because of their properties which leads them a wide usage area. Being sub-group of borates, potassium borates show non-linear optical properties and owing to this they can find applications in optical modulation, optical switching, optical logic andmemory, signal processing. Potassium borates can be used in welding, insulation, metal refining and lubricating oil production applications, also. In this study, potassium borates were produced from potassium chloride (KCl), sodium hydroxide (NaOH) and boron oxide (B2O3) when different molar ratios of B2O3 were used to find out the optimum ratio for the synthesis at 80°C and 1 hour of reaction time. The molar ratios of reactants were examined as 1:1:3 (as KCl:NaOH: B2O3), 1:1:4, 1:1:5, 1:1:6 and 1:1:7. The identification of products and the effects of different molar ratios on the final product were determined by X-Ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FT-IR) methods. According to experimental results, the Santite (KB5O8·4H2O)mineral with powder diffraction file number (pdf) code of 01-072-1688 was produced for all molar ratios whereas the optimum ratios in which highest XRD score was obtained was 1:1:7.

References

1. S. Sathiskumar, T. Balakrishnan, K. Ramamurthi, International Journal of Science and Research (IJSR), 2014, Paper ID: SUB141126, 2319-7064.

2. V. Joseph, V. Santhanam, S. Gunasekaran, P. Sagayaraj, S. Ponnusamy, Indian Journal of Pure & Applied Physics,2003, 41, 161-166.

3. F.Y. Zhu, C.H. Fang, Y. Fang, Y.Q. Zhou, H.W. Ge, H.Y. Liu, Journal of Molecular Structure, 2014,1070, 80-85.

4. F.Y. Zhu, C.H. Fang, Y. Fang, Y.Q. Zhou, H.W. Ge, H.Y. Liu, Journal of Molecular Structure, 2015, 1083471-479.

5. H. Gürbüz, G. Badem, A.N. Bulutçu, Journal of Crystal Growth, 2005, 283, 222-229.

61

OR-61 Determination of metal content in the water and sediments located around Siirt

İbrahim Teginaand Uyan Yükselb

a Department of Chemistry, Faculty of Arts and Sciences, Siirt University, Siirt, Turkey b Department of Chemistry, Faculty of Arts and Sciences, Dicle University, Diyarbakır, Turkey

Abstract

18 water samples and 10 sediment samples from the water found around of Siirt were taken. While there

is no As,Cd, Co, Hg, Mo, Pb and Sb in waterlocated around Siirt (Kezer Stream, Şirvan Stream, Botan Stream

and Zorava Stream), some metals (As, Cd, Co, Cr, Cu, Fe, Hg, K, Li, Mg, Mn, Mo, Na, Ni, Pb, Se, Sb, Sr, Ti,

Tl, V and Zn) were determined in sediments by ICP-OES enstrument.The average metal content in sediments

has been determined as 0.72±0.28 for As,0.51±0.13 forCd, 0.40±0.12 for Co, 2.09±0.69 for Cr, 0.94±0.31 for

Cu, 712±352 for Fe, 2.81±1.77 for Hg, 63.50±68.50 for K, 1.00±0.30 for Li, 1663±945 for Mg, 11.25±3.47 for

Mn, 0.10±0.03 for Mo, 14.71±12.51 for Na, 2.69±1.30 for Ni, 0.20±0.07 for Pb, 6.11±2.15 for Sr, 4.38±2.25

for Ti, 087±0.38 for V and 0.62±0.37 for Zn. For average metal content in water samples, it was determined as

0.03±0.02 for Cr, 0.04±0.03 for Cu, 2.75±4.34 for Fe, 10.61±12.55 for K, 0.04±0.01 for Li, 17.81±9.79 for Mg,

0.07±0.08 for Mn, 19.21±29.91 for Na, 0.03±0.03 for Ni, 0.36±0.13 for Sr, 0.05±0.05 for Ti, 0.01±0.01 for V

and 0.31±0.47 for Zn.Chemometric techniques such as the PCA, LDA and PCR to sediment and water samples

was applied.

Key words:Metal, Copper, Cobalt, heavy metal, sediment.

REFERANCES

1. Xiang H., Mika S., Egil T. G., Rolf D. V., Water quality in the Tibetan Plateau: Major ions and trace elements in the headwaters of four major Asian rivers, Science of the Total Environment 407 (2009) 6242–6254

2. Yiğiterhan O., James W. M., Tuğrul S., Trace metal composition of suspended particulate matter in the water column of the Black Sea, Marine Chemistry 126 (2011) 207–228

62

OR-62 Determination of Nitrate,Fluoride and Methyl Tertiary-Buty Ether by Aqueous Solution

Using Amin Multi Walled Carbon Nanotubes. Hamideh Yahyapour1Omid Moradi2

1Hamideh Yahyapour

[email protected]

2Omid Moradi [email protected]

Department Of Chemist, College Of Science, Shahr-e-Qods Branch,Islamic Azad University, Tehran, Iran

Abstract Nitrat, Fluoride and Methyl tertiary-buty ether Is the Most Important Polluanats of Surface and Underground Water Which Enter into Resoueces Through Domestic. The Aim of This Research Was to Study the Efficiency of Nitrat, Fluoride and Methyl tertiary-buty ether Removal in Drinking Water Using Amin Multi Walled Carbon Nanotubes and also Determination of the Optimum Condition s. Then, Effect of Factors Such as pH, Exposure Time, Ionic Strangle, Dosage of Nanotube, Concentraction of Nitrat, Fluoride and Methyl tertiary-buty ether Were Studied. Finding Revealed that Nitrat, Fluoride and Methyl tertiary-buty ether Removal Leval Incraesed as pH Decreased and Exposure Time Increased. Also, as Nitrat, Fluoride and Methyl tertiary-buty ether Concentration Increased, Nitrat, Fluoride Removal Increased but Methyl tertiary-buty ether Removal Decreased. Ionic Strangle Removal Decreased. Therefore, to Removal Higher Levels of Nitrat, Fluoride and Methyl tertiary-buty ether, Optimal Experimental Conditions Should be Determined. Keywords:Nitrate, Fluoride , Methyl tertiary-buty ether, Amin Multi Walled Carbon Nanotubes.



63

OR-63 The Hydrogenation of Carbon Dioxide over Nanostructured Zr/Si Oxide Contacts

Shaxla TAGIYEVA, Nushaba ALIYEVA, Lala QASIMOVA, Etibar ISMAILOV

Institute of Petrochemical Processes, Azerbaijan National Academy of Sciences, AZ1025, 30,Khojaly Ave.,Baku, Azerbaijan, e-mail: [email protected]

Abstract: It is believed that the increase in carbon dioxide emissions into the atmosphere leads to environmental degradation due to global warming and climate change. One of the solution of this problem is the conversion of CO2 into valuable chemical products. Among the methods of CO2 processing, the catalytic hydrogenation of CO2 is one of the most appropriate [1,2]. Methanationof carbon dioxide is thermodynamically favorable reaction (ΔG298K = -130,8kJ ∙ mol-1). However, the reduction of fully oxidized carbon occurs with significant kinetic limitations that require the use of effective catalysts for achieving acceptable activity and selectivity [3]. In the present work the results of the catalytic hydrogenation of CO2 into hydrocarbons, mainly methane over nanostructured samples of Zr/Si oxide catalyst are given. The phase composition of the samples and distribution of active element on the surface of the samples before and after the reaction at different temperature and composition of reaction mixture were characterized by X-ray diffraction and X-ray fluorescence microscopy methods, respectively. The degree of dispersion of samples in the liquid phase is determined by dynamic light scattering. The results of the hydrogenation of the CO2 on Zr/Si oxide catalyst at 480oC are shown in Table 1.

Table 1. Results of hydrogenation of CO2 on Zr/Si oxide catalyst at 480oC Catalyst Zr/Si

СО2 :Н2 Conversion, % Yield of CH4, %

After calcinations at 6000С 1:1 3,5 1,2 After calcinations at 8000С

1:1 7,4 2,4 1,2:1 10 3,3 2:1 2,5 0,8 1:2 3,9 1,3

Without Catalyst 1:1 1,5 0,5 References

1. B. Hu, C. Guild, S.L. Suib..J.CO2 Util. 2013, 1, 18-27. 2. S.Saedi, N.A.S.Amin,M.R.Rahimpour.J.CO2 Util. 2014, 5, 66-81. 3. W.Wang. S.P.Wang, X.B.Ma. J.L.Gang. Chem. Soc. Rev. 2011, 40, 3703-3727.

64

OR-64 Absorbtion Cooling Systems for Ships

Mesut TANER Department of Naval Architecture,Institute of Marine Sciences and Technology, Dokuz Eylül University, İzmir, Turkey

Abstract: In this study the main typesof cooling systems and their working principles have beenintroduced. Absorption coolingsystems and principles of operation have been described. All elements of the absorbtion cooling system and the cooling process have been described. Absorption cooling syatems ofLiBr-H2O and NH3-H2O working fluids using waste heat of ship’s main engines are compared. Advantages and disadvantages of these refrigerants are explained. Analysis of the systems have been introduced. The software that used for calculating was introduced briefly and the LiBr-H2O and NH3-H2O systems is showed in detail. A passenger ship and a fishing vessel main engines used in the different exhaust temperatures and loads. Pressure boundaries and coefficient of performance values has been assumed to be constant. Under these assumptions, potential cooling load capacities have been calculated. The results showed that absorption cooling system for cruise and fishing ships has adequate capaticity to provide cooling loads.

Scheme1.Absorbtion cooling cycle.

References

1. K. E. Herold, R. Radermacher, K. A. Sanford, Absorbtion Chiller and Heat Pumps,1996. 2. P. Srikhirin, E. and et.al., Renewable and Sustainable Energy Reviews, 2001, 343-372. 3. A. Şencan, K. Yakut, S. Kalogirou, Renewable Energy,2005, 30, 645-657.

65

OR-65 Boric Acid Production from Sodium Metaborate with Sulphuric Acid

Hilal Seda DEMİREL, Taylan Efe İNCE, Duygu UYSAL, Bekir Zühtü UYSAL Department of Chemical Engineering, Faculty of Engineering, Gazi University, Maltepe, Ankara, Turkey

[email protected]; [email protected]; [email protected]

Abstract: Boric acid is a refined boron product used widely in chemical industry as well as for the production of sodium borohydride. Sodium borohydride is a hydrogen carrier and is gaining increasing importance in the anticipated hydrogen era in the near future. Hydrogen can be generated by catalytic hydrolysis of sodium borohydride.

Sodium metaborate is the byproduct of this reaction. It is important to recycle sodium metaborate to the process of sodium borohydride production. Direct recycling is very difficult. However, when sodium metaborate is converted to boric acid, it can be used as the raw material in the Schlesinger method, where boric acid (B(OH)3 or H3BO3) is first converted to trimethyl borate (B(OCH3)3), which then reacts with sodium hydride to yield sodium borohydride (NaBH4). Thus, in this research, boric acid production with aqueous phase reaction of sodium metaborate with sulphuric acid is investigated. Sodium metaborate obtained from ETI-Maden General Directorate was reacted batchwise at 90oC for 30 minutes with 98%H2SO4 solution using stoichiometric amounts according to the following reaction;

The reaction mixture was then cooled to 10oC to allow crystallization of the reaction products. As the solubility of Na2SO4 in aqueous solutions at 10oC is about 9.0 g/100 mL compared to 3.57 g/100 mL for B(OH)3, most of sodium sulphate remained in the solution. Crystals, essentially boric acid, were separated by vacuum filtration and dried in an oven at 50oC for 6 hours. Boric acid with 96.15% purity could be produced by this outlined merhod. Further purification was also investigated using ethanol, acetone and saturated boric acid solution itself and 97.78%, 97.98% and 100% pure products were obtained, respectively. These results, supported by XRD analysis, indicate that the proposed method was successful and it is possible to produce boric acid by reacting sodium metaborate directly with sulphuric acid.

References

1. İ. Kayacan, Ö. M. Dogan, B. Z. Uysal, Int Jr of Hydrogen Energy, 2011, 36 (13), 7410-7415. 2. Gögce, Ö. Ö, U. G. Zafer, B. Z. Uysal, Proceedings of 4th Intn. Boron Symposium, 2009, Ed. A. Konuk et al., Eskişehir, 267-271. 3. Schlesinger, H. I., H. C. Brown, A. E. Finhold, Jr of American Chemical Society, 1953, 75, 205-209.



66

OR-66 Effect of Aqueous Extracts of Leaves, Seeds and Stem Bark Of Moringa Oleifera on Some

Bacteria and Fungi Isolated from Spoilt Locally Produced Soymilk

Abiona, Dupe Lydiaa, Adegbola, Racheal Adebolab,Olanrewaju Bernice Jejelolac. a,b, Department of Chemistry, The Polytechnic, Ibadan, Oyo State, Nigeria.

c Science Laboratory Department, The Polytechnic, Ibadan, Oyo State, Nigeria.

ABSTRACT Aqueous extracts of Moringa oleiferaseeds,leaves and stem bark were studied for their antimicrobial activities against some bacteria and fungi isolated from spoilt locally produced soymilk, at five different concentrations of 20mg/ml, 40mg/ml, 60mg/ml, 80mg/ml and 100mg/ml of the extracts. The aim of this study is to find an alternative, but safe and cheaper way of preventing soymilk from spoilage, thereby preserving it. The bacteria isolates wereEscherichia coli, E.faecalis,S. aureus,Bacillus spp.,Clostridium spp. while the isolated fungi were Aspergillus niger, Candida albican, penicillum spp. Fusarium spp. and Geotrichum candidium.. The result of the study showed that the seeds, leaves, and stem bark aqueous extracts ofMoringa oleiferawere activeagainst the tested bacteria and Aspergillus nigerat all concentrations. At all concentrations used, the seeds aqueous extract was active againstCandida albicanand Fusarium spp., but penicillum spp.andGeotrichum candidiumwere resisitant to it. The leaves aqueous extract was active againstpenicillum spp., and Fusarium spp.but not against Candida albican andGeotrichum candidium. The stem bark aqueous extract was active against Candida albicanandGeotrichum candidium, but was not active against penicillum spp., and Fusarium spp.Thus it could be inferred that Moringa oleiferaseeds, leaves and stem bark could be used in soymilk to prevent the activity of the organisms against which they were active. References

Lee, S.Y, Morr, C.V, Seo, A, (1990).Comparison of Milk-Based and Soy milk-based Yoghurt. Journal of Food Science, 55(2): 532-536.

Kolapo, A.L.and Oladimeji, G.R. (2008). Production and quality evaluation of Soy-corn milk. Journal

of Applied Biosciences, Vol.1 (2): 40 - 45.

Dhawale, S. and LaMaster, A. (2003). Microbiology Laboratory Manual. The McGraw Hill companies incorporation USA. Pp: 13-15.

Cowan, S. T. (1974): Cowan and steel’s Manual for the identification of Medical bacteria. 2nd edition,

Harper and Row London. Pp: 39.

67

OR-67

Characterization of Biosensor Application by Atomic Force Microscope (AFM): Modification of Gold Screen Surface by Dendrimeric Structures and Biological Molecules

Dilek GÜNGÖRa aDepartment of Forensic Sciences,Institute of Security Studies, Turkish National Police Academy, Ankara

Abstract:

Self-Assembled Monolayers have been attracting more attention due to studies over potential applications of biosensors, nanotechnology and bimolecular electronics. Immobilization of biomolecules over the surface of SAM in order to fabricate biosensors is an important application. SAM can be modified with other adopted strategies for biosensor applications (Arya, 2009). Dendrimers are synthetic macromolecules which has branches like a tree and many approaches have reported their usage as biosensor materials (Zhang, 2009; Liu, 2005). Displaying the prepared surface with a SAM techniques and elucidation is quite an important issue today. For this purpose, Atomic Force Microscopy ( AFM) are used to detect sensor surface. Quartz Crystal Microbalance(QCM) which detects changes occurring and measures the mass of quartz crystal surface, is a successfultechnique ( Bourday , 2009). QCM uses the properties of piezoelectric quartz crystal to measure the change in the mass of the connected surface ( Snook, 2009). In each of the biosensor preparation steps , the success of adhesion to the surface is measured with QCM. The purpose of this study is to ensure the success of the implementation process and to sustain characterization of surface throughout preparation phase of 1. Generation of enzyme -based amperometric biosensors. Alcohol oxidase enzyme, was immobilized to gold screen printed electrode with in the presence of 4th generation Poly(amidoamin) (PAMAM) by cross-linking with glutaraldehyde by the method of SAM. Each step in the preparation of the biosensor was monitored using AFM and QCM . The obtained data shows that each step in the preparation of sensor proceeds as foreseen.

References

Arya, S.K., Solanki, P.R., Datta, M., Malhotra B.D. (2009). Recent advances in self-assembled monolayers based biomolecular electronic devices. Biosensors and Bioelectronics 24: 2810–2817.

Boujday, S., Méthivier, C., Beccard B., Pradier, C. M. (2009). Innovative surface characterization techniques applied to immunosensor elaboration and test: comparing the efficiency of fourier transform–surface plasmon resonance,quartz crystal microbalance with dissipation measurements, and polarization modulation–reflection absorption infrared spectroscopy. Analytical Biochemistry no. Of pages 8, model 5G

Liu, Z. M., Yang, Y., Wang, H., Liu, Y. L., Shen, G.L., Yu, R. Q. (2005). A hydrogen peroxide biosensor based on nano-Au/PAMAM Dendrimer/cystamine modified gold electrode. Sensors and Actuators B 106: 394–400

Snook, G.A. (2009). Doktora tezi; Investigation of Solid-State Reactions by Electrochemical and Quartz Crystal Microbalance Measurements, Chapter 1. Introduction to electrochemical, quartz Crystal microbalance and structural Techniques used to characterise redoxreactions. Monash University.

Zhang, Z., Yang, W., Wang, J., Yang, C., Yang, F., Yang, X. (2009). A sensitive impedimetric thrombin aptasensor based on polyamidoamine Dendrimer. Talanta 78: 1240–1245

http://tureng.com/search/successful

68

OR-68 Magnetic Properties of Self-Assembled Magnetite Nanoparticles via Spin and Dip Coating

Methods

Sinem Esir(a),, Ayşe Demir Korkmaz(b), Huseyin KAVAS(a) aDept. of Engineering Physics, Istanbul Medeniyet University, 34700 Istanbul, Turkey, [email protected]

bDept. of Chemistry, Istanbul Medeniyet University, 34700 Istanbul, Turkey, ayse.demir@korkmaz cDept. of Engineering Physics, Istanbul Medeniyet University, 34700 Istanbul, Turkey, [email protected]

Abstract: The nano-self-assembly of size and shape controlled magnetic nano particles were obtained by spin and dip coating methods. Crystal structure, size distribution and morphology of particles were analysed by X-Ray Diffraction method and Transmission Electron microscopy (Figure 1.), respectively. The magnetic properties of thin films were investigated by both Vibrating Sample Magnetometry and Ferromagetic resonance spectroscopy in parallel and perpendicular to the film surface. The magnetic anisotropy is obtained in thin films under certain coating conditions. It is found that the thin film coating procedure is important for mono or multi layered nanoparticles. The results were summarized as follows: i) The coexistence of ferromagnetism at lower magnetic fields and diamagnetism at higher magnetic fields is observed some samples, ii) by increasing the nanoparticle concentration the high field diamagnetism is vanishes, iii) the mono layered or low number of layered (eg. 2 or 3) thin film is obtained with least magnetic interactions in out of plane directions.

2 4 6 8 10 12 14 16

0

10

20

30

40

50

60

Co

un

t

D (nm)

NP Size Distribution

Log-normal fit

Figure 1. TEM micrograph of sample D2 and its particle-size distribution Acknowledgment: The financial support provided by TUBITAK (the Scientific and Technological Research Council of Turkey) with Project number 113F106 is gratefully acknowledged.

OR-69 Liquifying Slimes and Some Oxidized Lignites*

a Mehmet ÇÖTELİ, b Akan GÜLMEZ, b Ayşe ERDEM, a Mehmet KARAKAŞ, a Abdullah ULAŞ, c Assoc. Prof. Selami TOPRAK, c PhD.Emine SÜTCÜ,

a Polat CANDAN

a Mineral Analysis and Technology Department, Laboratory Analysis Coordinatorship, MTA, Ankara, TURKİYE b Mineral Analysis and Technology Department, Ore Processing Coordinatorship MTA, Ankara, TURKİYE

c Mineral Analysis and Technology Department, Mineralogy and petrography Coordinatorship, Ankara, TURKİYE

Abstract:

69

Lignite and slime wastes are, in particular, troublesome coals to be beneficiated. Karapınar, Gölbaşı, Hüsamlar,

Alatepe, Ören and Bağyaka coals in Turkey are typical coals to exhibit oxidized, high moisture, sulfur, metal

toxicity and low calorific containing properties which carry health risks and needs to be re-evaluated. Tunçbilek and Dereköy slime wastes are difficult to be used too and a new look is considered to handle it with an alternative way to be re-evaluated besides the conventional utilizations The coal acids produce alkanolamine, alkylate oxide, polyhydroxyle compounds or polyamines and thermosetting compounds which are shaped under high temperatures (Montgomery, 1959). These reactions are;

R(COOH)3+HN(CH2CH2OH)2 →R(COOCH2-)2(CONCH2

-) 1 eq. R(COOH) + 1 mole HN(CH2CH2OH)2→R(CONCH2)2

Besides, the coal liquefaction processes are not only composed of individual dissolutions but also many inner reactions which recoveries of them become dependent on (Çöteli et al., 2008). Pullen (1981), classified the chemicals to extract coals with organic dissolvers as; simple dissolver (under 100 0C), special dissolvers (special dissolvers and mixtures working under 200 0C), dissolvers which may be deteriorated or difficult to recover (phenantrene, biphenyl and phenanthyridine like dissolvers to dissolve coals up to 90% levels under about 400 0C) and reactive dissolvers(generally providing hydrogen transfer from the chemicals such as isopropyl alcohol, potassium isopropoxide, potassium hydroxide with tetraline effect above 400 0C). In the study, as a result of dissolution of the coals, with a mixture of 50% (v/v) trietanolamine (TEA) and pyridine at 120-160 0C, with liquid/ solid ratio of 60% and 120 minute retention period at moisture and ash free basis, <80% of the liquefaction efficiency for Gölbaşı, Hüsamlar, Alatepe, > 50% for Işıktepe, Dereköy Slime

waste and < 50% for Bağyaka, Eskiahır, Tunçbilek-Slime also <50% Dodurga were obtained. In addition, a liquid with lower calorific value (LCV), at the moisture and ash free basis, with >7863 kcal/kg was produced.

*This study was supported by MTA under the 2015-35-16-04 numbered conducted research Project. References:

1. Montgomery, S., 1959. “Coal Acids”, Chem. Eng. News, Sept, 28, p 96; Perry, op. cit.; Burke, op, cit. 2. Pullen, R, J ., 1981. “Solvent extraction of coal”, London : IEA Coal Research

70

OR-70 Synthesis and Investigation of Their Antimicrobial Activities of new Conazole Derivatives

Containing Morpholine and Fluorophenilene rings *

Hacer BAYRAKa, Yıldız UYGUNb, Arif MERMERb, Serap BAŞOĞLUb, Neslihan DEMİRBAŞb, Ahmet DEMİRBAŞb, Şule CEYLANc, Serpil DEMİRCİd

aDepartment of Chemistryand Chemical Processing Technologies, Karadeniz Technical University, Trabzon, Turkey bDepartment of Chemistry,Karadeniz Technical UniversityTrabzon, Turkey

cDepartment of Occupational Health and Safety, Artvin Çoruh University,Artvin,Turkey dDepartment of Part of Crop Production and Technologies, Giresun University, Giresun, Turkey

Abstract: The therapeutic effects of 1,2,4-triazoles have been well studied for diverse patological conditions including inflammation, cancer, pain, tuberculosis and hypertension. In the past decades, the problem of multi-drug resistant microorganisms has reached on alarming level around the world. For the treatment of microbial infections, the synthesis of new anti-infectious compounds has become an urgent need. For this purpose, several compounds that contain a morpholine nucleus possessing antimicrobial activity have been synthesized; some which contains an azole ring also. For instance, while Eperezolid, and AZD2563, which are the members of oxazolidinone class antibiotics, consist of morpholine and oxazolidinone rings bearing with each other via a fluorophenilene linkage, another antibiotic, Linezolid, contains a piperazine ring instead of morpholine. In this study, some 1,2,4-triazole derivatives containing morpholine and fluorophenilene ring and also conazole skeleton were synthesized and screened for their antimicrobial activities.

.

NO

F

NHN

NHN

ONO

F

NHN

NN

O

O

Cl

X

NO

F

NHN

NN

O

Cl

OH

X

Na, EtOH

1

2a: X=Cl; 2b: X=H

EtOH, 8h, reflux

NaBH4

3a: X=Cl; 3b: X=H

NO

F

NHN

NN

O

Cl

O

X

Cl

4a: X=Cl; 4b: X=H Scheme1.Synthesis Routes of Compounds 1-4(a-b).

*This study is supported by a grant (Project Number: 113Z181) from TUBITAK.

References

1. N. Demirbas, S. A. Karaoglu, A. Demirbas, K. Sancak, Eur. J. Med. Chem., 39 (2004) 793-804. 2. C. G. Bonde, N. J. Gaikwad, Bioorg. Med. Chem.12 (2004)2151-2161. 3. H. Bayrak, A. Demirbaş, N. Demirbas, Karaoğlu S.A., Eur. J. Med. Chem., 45 (2010) 4726-4732.

71

OR-71 SynthesisandCharacterization of GreenPolyurethanes Using NovelVegetableBasedPolyols

Kemal Karadeniz1, Yakup Çalıkoğlu 1Department of Chemistry, Faculty of ScienceandLiterature, Sakarya University, Serdivan, Sakarya, Turkey

Presenting Author: [email protected]

Vegetableoilsareattractiverenewablesourcesforproduction of bothmaterialsandfuels. Inrecentyears, a

variety of polymericmaterialshavebeendeveloppedwithvegetableoils as startingmaterial. Amongotherpolymers,

vegetablebasedpolyurethanes (PU) arethemostextensivelystudiedduetotheirsamplepreparation.

VegetablebasedPusaregenerallypreparedbyfirstconvertingoilsintopolyols,

followedbycuringwithdiisocyanates[1].Inthisstudy,twonewvegetablebasedpolyolsprepredwiththioglycolicacid

(TGA) andglycolicacid (GA) containingbifunctionality, carboxylicandthiol (orhydroxyl)

functionalitiessynthesizedveryrecently[2]wereusedfornovelpolyurethanesynthesisusing4,4´- methylene-

bis(phenylisocyanate)(MDI).SoybeanoilbasedpolyurethaneswerechracterizedbyFourierTransforminfra-

RedSpectroscopy (FTIR), physicalpropertieswereassesedbyDifferentialScanningCalorimetry (DSC), Thermo-

GravimetricAnalysis. Tensile propertiesweremeasured. New polyurethanesdemonstratedwiderange of tensile

propertierangingfromveryflexibletorigid ( from 3.44 to39.7Mpa) tensile strengthbased on changingpolyol / MDI

ratio. Withthesamepolyol / MDI ratio, thebest tensile propertieswereobtainedwithpolyolhaving SH

functionality.

References

1. ShidaMiao, SongpingZhang, Zhiguo Su, PingWang,A novelVegetable Oil LactateHybridMonomerforSynthesis of High Tgolyurethanes, , RapidCommunication,J.Polym.SCI. Part A: Polym. Chem. Vol.48, 248-253 (2010) 2.Kemal Karadeniz1, Hatice Akı, Mustafa Yasin Sen, Yakup Calıkog˘lu,Ring Opening of EpoxidizedSoybeanOilwithCompoundsContainingTwoDifferentFunctionalGroups. Journal of theAmericanOilChemists' Society: Volume 92, Issue 5 (2015), Page 725-731

OR-72

Comparison of %1 Nd and %1 Pr Doped %25 TiO2-MMT Composite Photocatalyst Amount on Azo Dye ( Basic Yellow 28) Oxidation*

Başak OTSUKARCI, Yasemen KALPAKLI Department of Chemical Engineering, Faculty of Chemical Engineering and Metallurgical Engineering, Yıldız Technical University, TR-

34210, İstanbul, Turkey Abstract: TiO2 has an irradiation property of 5% under UV light which limits its ability to be used under solar spectrum. In order to increase its capacity TiO2 was modified with rare earth ions of Neodymium (Nd) and Praseodymium (Pr), using acid sol-gel method. By doing so, TiO2’s absorption edge has been extended towards the visible light. It is also known that, rare earth ions can strongly adsorb various

72

organic pollutants and remedy decolorization of dyes by forming complexes with various Lewis bases such as aldehydes and amines to break down aromatic compounds. Furthermore, rare earths can reduce the crystalline size and increase the surface area of the photocatalyst. BET surface areas for 1% Nd doped 25% TiO2-MMT is 195.51m2/g while for 1% Pr doped 25% TiO2-MMT is 202.25m2/g. Montmorillonite (MMT) is the mineral form of bentonite clay, cheap and widely found in our country. We bought the mineral from Esan Eczacıbaşı Industrial Raw Materials Incorporated Company, Kütahya. We used MMT as a supporting material to improve the surface area of titania (TiO2) synergistically with rare earth elements in order to achieve higher adsorption capacity to enhance photooxidation. Our results showed that doping TiO2-MMT photocatalyst with 1% Pr yielded higher adsorption and oxidation capacities compared to doping with 1% Nd ion. We kept the model pollutant concentration (BY 28) at 100ppm throughout the experiments. Under 15 minutes of adsorption in the dark and 1 hour of UV-A illumination of 365nm wavelenght with using 2.5g/L photocatalyst Nd doped achieved 76.61% whereas Pr doped with using only 1.0g/L achieved 81.96% yield under the same circumstances. Further increase in illumination of Nd doped to 5 hour increased the degradation to 89.12% considering in 2 hours of illumination for 1% Pr doped achieved 86.30% degradation according to TOC results. Degradation rate is found also higher in Pr doped photocatalyst than Nd doped photocatalyst. *This study is supported by a grant (Project Number: 2014-07-01-YL05) from Scientific Research Projects Committee of Yıldız Technical University.

References

1. F. Zhang, J. Zhao, T. Shen, H. Hidaka, E. Pelizzetti, N. Serpone, Applied Catalysis B: Enviromental, 1998, 15, 147-156. 2. C. Liang, C. Liu, F. Li, F. Wu; Chemical Engineering Journal. 2009, 147,219-225. 3. T. L. R. Hewer, E. C. C. Souza, T. S. Martins, E. N. S. Muccillo, R. S. Freire; Journal of Molecular Catalysis A: Chemical. 2011, 336, 58-63. 4. Y. Zhang, H. Xu, Y. Xu, H. Zhang, Y. Wang; Journal of Photochemistry and Photobiology A: Chemistry. 2005, 170, 279-285.

73

OR-73 The Synthesis of MSU-X Mesoporous Materials from Sodium Silicate*

Nevin KARAMAHMUT MERMERa, Sevil Begüm KARAKAŞa, Müge SARI YILMAZa

aDepartment of Chemical Engineering,Faculty of Chemistry and Metallurgy, Yıldız Technical University, TR-34220, İstanbul, Turkey Abstract: MSU-x (MSU represents Michigan State University) materials are a family of ordered mesoporous silica obtained by using nonionic poly(ethylene oxide)-based surfactants [1]. MSU materials have many application areas due to their mesoporous structure, high mass oil cracking activity and high thermal stability [2]. In recent years MSU mesoporous materials were used in adsorption, catalytic applications, separation process, and drug delivery system [2-6]. In this study, MSU mesoporous silica materials were synthesized from sodium metasilicate pentahydrate (SMP) which is more cost-effective than the tetraethyl ortosilicate (TEOS) as a silica source and Pluronic 123 as a nonionic structure-directing triblock copolymer surfactant in an acidic medium. The synthesized materials were characterized by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) analyses. The obtained results showed that the MSU-x was successfully synthesized.

*This study is supported by a grant (2014-07-01-GEP04) from Scientific Research Projects Committee of Yıldız Technical University.

References

1. C. Boissie`re, A. Larbot, E. Prouzet, Chemistry of Materials 2000, 12, 1937-1940. 2. K S. Triantafyllidis, E. F. Iliopoulou, E. V. Antonakou, A. A. Lappas, H. Wang, T. J. Pinnavaia, Microporous and Mesoporous Materials, 2007,99, 132-139. 3. Y. Jung, S. Kim, S. J. Park, J. M. Kim, Colloids and Surfaces A: Physicochem. Eng. Aspects, 2008. (313-314), 162-166. 4. H. Liu, Z. Wang, H. Hu, Y. Liang, M. Wang, Journal of Solid State Chemistry, 2009,182, 1726-1732. 5. E. Prouzet, C. Boissiere, C. R. Chimie,2005,8, 579-596. 6. M. Kruk, M. Jaroniec, J. Phys. Chem. 2001,105, 7663-7670.

74

OR-74 The Effect of Acid Concentration on the Synthesis of Hydrophobic Silica Based Aerogels*

Müge SARI YILMAZa, Özgül DERE ÖZDEMİRa, Nevin KARAMAHMUT MERMERa, Mehmet Burçin PİŞKİNb

aDepartment of Chemical Engineering,Faculty of Chemistry and Metallurgy, Yıldız Technical University, TR-34220, İstanbul, Turkey

bDepartment of Bio Engineering, Faculty of Chemistry and Metallurgy, Yıldız Technical University, TR-34220, İstanbul, Turkey

Abstract: Aerogel has a meaning of an air gel that made of a gel solution [1]. Aerogels are transparent and highly porous materials which known with low density. Since the 1930’s, researcher has been focused on the synthesis methods and applications of aerogel [2]. In recent years, silica aerogels were used in optics, microelectronic, electrical engineering, acoustics, heat insulation, capture of micro particles, pharmaceutical, chemistry, and biology [1-3]. In this study, the effect of the acid concentration on the synthesis of hydrophobic silica based aerogel was investigated. Tetraethyl orthosilicate (TEOS) and chlorotrimethylsilane (TMCS) were used in the synthesis as a silica source and silylation reagent, respectively. Different concentrations (0.5 M, 1 M, and 1.5 M) were investigated to see the effect of acid in the synthesis of silica based hydrophobic aerogel. The analyses of FTIR and contact angle of synthesized samples were carried out. The results show that the optimum acid concentration was found as 1 M.

*This study is supported by a grant (2014-07-04-KAP02) from Scientific Research Projects Committeeof Yıldız Technical University.

References

1. N. K. Mermer, M.Y. Sarı, Ö. D. Özdemir, M. B. Pişkin, I. International Bioengineering Conference, 2015, 161- 164. 2. J. Fricke, T. Tillotson, Thin Solid Films, 1997. 297, 212-223. 3. Y. K. Akimov,Instruments and Experimental Techniques, 2003, 46(3), 287-299.

75

OR-75

Optimum ConditionsForChromatographicSeperation of N-NitrosodiphenylamineFromItsIntermediates

SinemDEMIR, Murat TORUN, DilekŞOLPAN Department of Chemistry, Hacettepe University,06800, Beytepe/Ankara - Turkey

[email protected] Abstract: Nitrosamines can be found in waste waters anddrinkingwaterbecause ofindustrialapplications as well as duringdisinfection of supplywater.Most of the nitrosamines were detected in waterwhicharecarcinogenic.N-Nitrosodiphenylamine(NDPhA)is selected as model compound in this study anditschromatographicseparationfromitsintermediatesafterrecoveryfromwaterwasexamined. Solid phase extraction (SPE) is a method of sample preparation that concentrates and purifies analytes from solution by sorption onto a disposable solid phase cartridge, followed by elution of the analyte with a solvent appropriate for instrumental analysis.In this study,the concentration process for aqueous solutions of NDPhAand the experimental conditionssuch as determination ofexperimentalparametersandreproducibilityafter SPE werestudied. Therecovery of NDPhA were followedbyusingDionex ICS 3000 systemafter SPE processbyThermoDionex AT280 withThermo Scientific Solex C18 cartridge (500 mg).Low concentration solutions of NDPhA were prepared and used fortheauto-concentratorsystemwhicharecarriedout at differentNDPhAconcentrations in water, varying from 0.01 to 2 mg/L. To increase the yield of NDPhAextractioninto the organic solvent, Carboxen 572 (Supelco, 20/45 mesh size), Alumina (BDH, for chromatographic adsorption analysis), Alumina (BDH, calcined) and Active Coal (Fluka, from peat, multi-purpose, steam activated and acid washed, powder) wereusedandused as filling materials. In this system, the aim was to determine the optimum experimental conditions, including filling material,volume of solvents, number of solvents, volume of the analyzed solution. Dichloromethane,hexane,methyl alcohol were selected as solvents. NDPhA was eluted with methyl alcohol and analyzed by Dionex IC 3000 HPLC. The results are shown that the recovery yield was up to %97. Using C18 cartridge was found to be more efficent method to seperate NDPhA from aqueous solution. *Thisstudy is supportedby a Project Number: 112T822from TUBİTAK

References: 1.J.Nawrocki, P.Andrzejewski;Journal of HazardousMaterials. 2011, 189, 1-18.

2.P.Andrzejewski, B.Kasprzyk-Hordern, J.Nawrocki;WaterResearch. 2008, 42, 863-870.

3.Y.Y.Zhao, J.M.Boyd, M.Woodbeck, R.C.Andrews, F.Quin,S.E.Hrudey, X.F.Li;Environ.

Sci. Technol.2001, 42, 4857-4862.

OR-76

Extraction, Characterization and Fatty Acid profile of African Star Apple Seed (Chrysophyllum albidum) Oil

Chidimma Emmanuel OMINYI

Department of Science Laboratory Technology (Chemistry), Akanu Ibiam Federal Polytechnic, Unwana-Afikpo, Ebonyi State, Nigeria. Abstract Oil was extracted from ChrysophyllumAlbidum seed using petroleum ether as solvent. The yield of the oil was found to be 4.98%. The result of characterization of the oil extract showed that it has iodine value of 163.3mg, Saponification value of 90.71mg, Acid


76

value of 19.70mg, Percentage Free Fatty Acid of 9.90% and Dirt content of 0.23%. The specific gravity of the oil at 250C and its content was found to be 0.8269 and 10.00% respectively. The color analysis gave Red, Yellow, Blue and Neutral to be 1.1, 2.2, 2.1 and 0.0 respectively. Thus the oil was found to be a drying oil. The Fatty Acid Profile of the oil was also determined with the aid of gas liquid chromatography used fatty acids in methyl esters and was found to have Oleic Acid (C18:1) as the predominant fatty acid having an area of 40.10125%. It was also found to contain Alpha Linoleic Acid (omega-3) and Linoleic Acid (omega-6) which are essential to the human body but cannot be synthesized by its metabolic processes. Key Word: ChrysophyllumAlbidum, Petroleum ether, Drying oil, Gas Liquid Chromatography, methyl esters, oleic acid, Alpha Linoleic Acid, Linolic Acid. References 1. Bada, S. O. National workshop on potentials of African star Apple in Nigeria. 1997. (1):16-25 2. Ihekoronye, O. F. and Ngoddy, B. F. Oils from local seeds in Nigeria. 1987, 3. Ibemesi, J. Vegetable oils as an Industrial raw material. 1992. 4. Katan, M. B. Zock P. L and Mensink, R. P. Am. J. Clin. Nutr. 1995. 61(6suppl): 1368S-1373S. 5. Ekpa, O. D. and Udo, A. E. West African journal of Biological and Applied Chemistry. 1994. 18-24.

77

OR-77 Vesicular Coacervative Microextraction of Pb: Green Alternative to Classical Extraction

Strategies Faheem Shah1, Tasneem Gul Kazi2, Naeem Ullah2

1Department of Chemistry, Faculty of Science, Federal Urdu University of Arts, Science and Technology. Gulshan campus, Karachi-Pakistan.

2National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro-Pakistan. Email: [email protected]

Abstract: In this work, coacervates made up of reverse micelles were assessed as a new separation/preconcentration strategy of trace lead (Pb) prior to its determination by flame atomic absorption spectrometry. The method is based on the extraction of Pb–(5-Br-PADAP)2chelate with coacervates of lauric acid(LA) aqueous vesicles in the presence of NaNO3. Bulk aqueous phase was carefully discarded from surfactant-rich phase and the remainder extract was redissolved in 500 μL of acidified methanol. Parameters affecting extraction efficiency such as pH, concentration of LA and 5-Br-PADAP, ionic strength, incubation and centrifugation time were studied. At optimum conditions, enhancement factor of 90, detection limit of 0.101 μg L−1, quantification limit of 0.336 μg L−1, relative standard deviation of 3.364% were achieved. No obvious negative effect of coexistent ions was observed on the determination of Pb. Validation was carried out by standard addition methodology. Finally, the method was applied for the determination of trace Pb in drinking and sea waters. Key words: Coacervates, micelles, lauric acid, preconcentration, lead

References

1. B. Delgado, V. Pino, J.H. Ayala, A.M. Afonso, V. González. Journal of Chromatography A. 2012,1257, 9– 18. 2. F. Merino, S. Rubio, D. Perez-Bendito, Journal of Chromatography A. 2003,998,143. 3. F.J. Ruiz, S. Rubio, D. Perez-Bendito, Journal of Chromatography A. 2004,1030, 109. A. Ballesteros-Gomez, F.-J. Ruiz, S. Rubio, D. Perez-Bendito, Anal. Chim. Acta.2007,603, 51.

78

OR-78 Transformation of Liquefied Gases of Catalytic Cracking in the Presence

of Polymer-supported Ionic Liquid Systems

Reyhan ALIYEVA, Yeter MAMMADOVA Institute of Petrochemical Processes named after academician Yu.G.Mamedaliyev, Baku, Azerbaijan

Abstract:

Currently, the progress of modern technologies has a great scientific and practical meaning for transformation of liquefied gases(LG) (C3-C4 fractions) which are separated from catalytic cracking to necessary petrochemical products, especially, high octane additives, new oligomer and polymer materials. Inefficient use of this fraction which has rich hydrocarbon content (propane, propene, (iso)butane, (iso)butene) is unacceptable ecological, biological and economical aspects [1, 2].

Presented research includes results of the experiments which have been developed of new efficient catalytic systems for obtain high octane additives with various transformation of LG. To this end, LG which contained about 40 – 50 % unsaturated hydrocarbons was used. Chloroaluminate type ionic liquidswere synthesized based on different amine hydrochlorides and AlCl3. Differentsulfonated polyolefins were selected as supported polymers.Products with molecular weightequal to 890-3320 were obtained from oligomerization process of LG in the presence of sulfosopolymers which were obtained based on polyolefins. As the result yield of obtained products compared to olefins is 15-25 wt %.

In this way, various transformations (alkylation, etherification, isomerization and oligomerization) of LGin the presence of the catalytic systems above, had been discovered.

Therefore, new catalytic systems for the implementation of various transformations of liquefied gases (which are separated from catalytic crackingand pyrolysis) are recommendedfor the future.

References: 1. A.Forestiere, H. Olivier – Bourbigou and L. Saussine. Oil & Gas Science and Technology – 2009, 64, 649 – 667. 2.http://www.intechopen.com/books/oligomerization-of-chemical-and-biological-compounds/the-use-of-ionic-liquids-in-the-oligomerization-of-alkenes

http://www.intechopen.com/books/oligomerization-of-chemical-and-biological-compounds/the-use-of-ionic-liquids-in-the-oligomerization-of-alkenes

http://www.intechopen.com/books/oligomerization-of-chemical-and-biological-compounds/the-use-of-ionic-liquids-in-the-oligomerization-of-alkenes

79

OR-79 LeachingKinetics of Zn from Zinc Plant Residue by Atmospheric and

High-temperature H2SO4Leaching

Mehmet ERDEMand Mehmet ŞAHİN

Department of Environmental Engineering, Fırat University, 23279 Elazığ, Turkiye

Abstract

In the hydrometallurgical zinc production processes, important amount of hazardous solid extraction residue containing unextractable Zn and Pb is generated. Due to increasing demand of metals and the depletion of high grade natural resources, these types of wastes are gaining great importance in the metallurgical industries. In this studyi, leaching and leaching kinetics of Zn from zinc extraction residue were investigated in atmospheric and high temperature conditions. For this purpose; the effects of H2SO4 concentration, contact timeand temperature on the Zn recovery from the residue were studied. The shrinking core model was applied to the results of the experiments. Leaching results obtained in atmospheric conditions showed that about 74 % Zn could be leachedunder the optimized conditions of 2 M H2SO4concentrationand 120 mincontact time.In high temperature H2SO4 leaching, 98.6 % zinc could be leached from the residue under the conditions of 2 M H2SO4 concentration, 100°C temperature and 60 min contact time. Leaching rates of lead were below 0.04 % in all conditions.Leaching kinetics of the zinc from the zinc extraction residue by atmospheric H2SO4 leaching fits the shrinking core model controlled by ash film diffusion, while that of the high temperature-pressure leaching fits a mixed mechanism with ash layer diffusion and chemical reaction. Activation energy values of both leaching process were determined to be 16.98 and 13.02 kJ/mol, respectively. *This study was financed by the Scientific and Technological Research Council of Turkey (TUBITAK) under the project number of 109Y262. References 1. M.K. Jha, V. Kumar, R.J. Singh,Resour. Conserv.Recy., 33,2001,1-22. 2. A. Özverdi, M. Erdem, Hydrometallurgy, 100, 2010,103–109. 3. M. D. Turan, H. S. Altundoğan, F. Tümen,Hydrometallurgy, 75, 2004,169-176. 4. M. Şahin and M. Erdem, Hydrometallurgy,153, 2015,170–178.

80

OR-80 Fast Oxidation and Optimization of some Lignite Samples

by means of Acid Leaching*

a PhD. Haydar POLAT, b Mehmet ÇÖTELİ, bMehmet KARAKAŞ, b Polat CANDAN

aThe Central Research Directorate of Soil, Fertilizer and Water Resources, TAGEM, Ankara, TURKİYE bMineral Analysis and Technology Department,. Laboratory Analysis Coordinatorship, MTA, Ankara, TURKİYE

Abstract

Nowadays, oxidation of organic materials and increasing demand of coal utilizations for agricultural purposes became inevitable in the scope of coal technologies. The natural coal oxidation is much time taking process and the material is called as leonardite in result. Recently, such material utilizations in modern agricultural applications, as soil conditioner and as organic material sources had rapidly increased. In this study, the parameters to increase oxidation of Tuncbilek coals after nitric acid treatment were found to be as heat, time, liquid/solid ratio, grain size, catalyst effect of zinc chloride (ZnCl2). The Tuncbilek coals were ground into less than 150 micron sizes. The liquid/solid ratio ofthe material were chosen as 10, 20, 30, 40 ratios to mix with HNO3 for certain period and let it rest. Humic acid analysis of the products was measured in various time durations, at dry basis. According to the obtained data, optimum liquid/solid ratio was obtained as 30, mixture period as 2 hours and rest period as 44 hours, in the order. Since the used HNO3 is volatile, the maximum temperature was chosen as 40 0C. Addition of zinc chloride (3-6g ZnCl2/100g) to the coal was found to increase the efficiency of the reaction. In order the reaction to start and to ensure the gas emission H2O2 or NaOCl like oxidant addition to the environment was found necessary. The humic acid values after the conducted acid leaching process depending on the determined optimum values at dry basis, was increased from 3.81% to 57.91% for Soma-Dereköy, from 4.85 to 32.46 for Tunçbilek and from 12.50% to 38.42%.

*This study was supported by MTA under the 2015-35-16-04 numbered conducted research Project.

References: 1. Çöteli, M., Usul, M., Dereköy, M., 2008. “Türkiye turba ve linyitlerinden humik bileşikler, organomineral

gübreler üretilebilirliği ve bitki büyümesinde etkisi”. TAGEM Araştırma projesi Sonuç Raporu. TAGEM –

BB-TOPRAKSU-2008/54.Genel Yay No:242, Rapor Seri NO:R-154. 2. Aksu, Z., Çöteli, M., Polat, H., 2009. “Elbistan linyitlerinin asit özütleme ile tarımsal açıdan

kıymetlendirilmesi”. TUBİTAK 107M043 nolu 1001 araştırma projesi sonuç raporu.

81

OR-81 Analytical Investigation of a New Sandwich Type Phthalocyanine and Oncogene

Interaction Esra Bağdaa, Ebru Yabaşb, Efkan Bağdac

a Cumhuriyet University, Faculty of Pharmacy, Sivas, Turkey

bCumhuriyet University, Faculty of Science, Department of Chemistry, Sivas, Turkey cCumhuriyet University, Faculty of Science, Department of Molecular Biology and Genetics, Sivas, Turkey

[email protected]

Abstract: Some phthalocyanine derivatives gain great importance with binding properties to biological molecules. Clarification of DNA-PC interaction mechanism with analytical chemistry methods have widely studied. Anti cancer drug development became important with the increase of morbidity and mortality of cancer. Uncontrolled cell division and proliferation of cancer is related with the increase of telomerase and oncogene activities. Therefore, anticancer drug development studies were focused on development of telomere and oncogen interactive molecules. In the presence of DNA-secondary structure interactive molecules, the cell division in malign cell has been ceased. It is widely observed that, secondary DNA structures are generally formed G rich regions of telomere and oncogen. In the present study, the interaction of sandwich type phthalocyanine with secondary DNA structures of oncogen will be investigated with analytical techniques. Synthesis of new type of stable complex former molecules with oncogen is a promising way for fight against cancer. *This study is supported by a grant (ECZ-014) from Scientific Research Projects Committeeof Cumhuriyet University.

References

1. D. Yang, K. Okamot;Future Med Chem, 2010, 2(4), 619-646. 2. J. Alzeer, B. R. Vummidi, P. J. C. Roth, N. W. Luedtke;Angew chem, 2009, 48, 9362-9365. 3. A. A. Salem, I. A. El Haty, I. M. Abdou, Y. Mu,Biochimica et Biophysica Acta, 2015, 1850 (2), 329-342 6. H. Yaku, T. Murashima, H. Tateishi-Karimata, S. Nakano, D. Miyoshi, N. Sugimoto,Methods, 2013,

64(1),19-27


82

OR-82 Turkish Primary ScienceTeacherCandidates’ Understandingsof some environmental

problems

Fatma AGGUL YALÇINa, Mehmet YALÇINa

aAgri Ibrahim Cecen University, Faculty of Education, Department of Elementary Education, Agri,TR-04000-Turkey

Abstract : The purpose of the study was to explore Turkish primary scienceteachercandidates'understanding of global warmingandozonelayer depletion. In the study, asthe research approach the surveymethod was used. Thesampleconsisted ofone hundred sixty-three thirdgradescienceteachercandidates. Data was collected using the tool developed by the researcher. The survey solicited writtenopinion responses tosevenopen-ended questions. Teacher candidates’ written opinionsaboutglobalwarmingand ozone layer depletion were analyzeddescriptively. Results of the analysiswere presentedaspercentages andfrequency. The findings suggest that prospective teachers’understandings about these issues were limitedand they had some significant common, misconceptions. Finally, the findings were discussed in comparison with previous results with respect to environmental education and then the study’s implications were presented.

83

OR-83 Effects of K+/Mn3+Addition on Microstructure of SrTiO3 Ceramics Selvin USTABAŞa, Zeki AYDINa, H. Zehra AKBAŞb,Muhammet DEMİRELa,

1Mustafa Kemal University, Faculty of Art and Science, Department of Chemistry, 31024 Hatay, TURKEY 2Mustafa Kemal University, Faculty of Art and Science, Department of Physics, 31024 Hatay, TURKEY

[email protected] Abstract:

One of the ceramic candidates, strontium titanate, which is as relatively strong as Eb,and has a high

dielectric constantεr, low dielectric loss etc., is themost promising dielectric material.It is widely known that

appropriate quantities of dopants can lead to increase indielectric properties. In the past several decades,

isovalent ions modified;divalent ions substituting for A-site (Sr2+) and tetravalent ions for B-site (Ti4+) [1-3].

Potassium and manganese were doped strontium titanate ceramics of formula Sr0,5K0,5Ti1-xMnxO3,

where x= 0, 0.25, 0.50 and 1.0, by solid state reaction route. The raw materials (SrCO3, TiO2, K2CO3, Mn2O3)

were weighed according to the stoichiometric composition of Sr0,5K0,5Ti1-xMnxO3 with different x values, and

then homogenized by ultrasound device by using acetone. The mixed slurry were dried and calcined at 1100 °C

for 2 h in an alumina crucible [4].

X-ray diffraction (Rigaku SmartLab Diffractometer, Cu Kα radiation) was performed to characterize the

phase structure of ceramic samples with a scanning speed of 3°/min and a step of 0.05° at room temperature.

Themicrostructurefeature of thecalcinedceramicswerecharacterizedby a scanningelectronmicroscopeJEOL-JSM

5500 equipped with an energy dispersive X-ray (EDX) detector.

REFERENCES: [1] Hu, Q., Shen, Z., Li, Y., Wang, Z., Luo, W., Xie, Z., 2014. Enhancedenergystorageproperties of dysprosiumdopedstrontiumtitanateceramics, Ceramics International, 40: 2529-2534. [2] Tkach, A., Vilarinho, P.M., Senos, A.M.R., Kholkin, A.L., 2005. Effect of nonstoichiometry on the microstructure and dielectric properties of strontium titanate ceramics, Journal of the European Ceramic Society, 25: 2769-2772. [3] Stanulis, A., Selskis, A., Ramanauskas, R., Beganskiene, A., Kareiva, A., 2011. Low temperature synthesis and characterization of strontium stannate-titanate ceramics, Materials Chemistry and Physics, 130:1246-1250. [4]Wang, Z., Cao, M., Yao, Z., Li, G., Song, Z., Hu, W., Hao, H., Liu, H., Yu, Z., 2014.Effects of Sr/Ti ratio on the microstructure and energy storage properties of nonstoichiometric SrTiO3 ceramics, Ceramics International, 40: 929-933.


84

OR-84 Solid-Liquid Extraction (Leaching) of Liquorice (Glycyrrhıza Glabra)

İrem KARAASLAN1,Zeki AYDIN1, Ali Coşkun DALIÇ 2,

1Mustafa Kemal University, Faculty of Art and Science, Department of Chemistry, 31024 Hatay, TURKEY 2Gaziantep University, Faculty of Engineering, Department of Food Engineering, 27310 Gaziantep, TURKEY

[email protected]

ABSTRACT:

Licorice are extensively used in anti-inflammatory, anti-viral, anti-allergic, anti-oxidant, gastro-protective, and

anticancerous properties, in food, confectionery and pharmaceutical products, such as cough syrups, herbal supplements, chewing

gums, drinks, and candy. It is used in two primary forms: roots (rhizomes) and extracts[1].

In this study; Licorice extract was produced by extracting the root with water. Expriments were carried out to establish the

optimum extraction procedure. So Brix measurements (°Bx), the concentration of dissolved solid to water, were carried out by a

digital refractometer and noted. Three temperatures (4 ˚C, 25 ˚C, 37 ˚C) and liquorice/water ratios (1/5, 1/4, 1/3) were selected for

leaching. ˚Bx increased with increasing temperature. The highest °Bx was obtained at 37 ˚C when the liquorice/water ratio was used

as 1/3.

REFERENCES:

[1]Ariño, A., Herrera, M., Estopañan, G., Juan, T. (2007). High levels of ochratoxin A in licorice and derived products. International

Journal of Food Microbiology , 114, 366–369


85

OR-85 Synthesis and Antimicrobial Evaluation of Nalidixic Acid Based 1,2,4-Triazole

Derivatives Şule Ceylana, Neslihan Demirbasb, Hacer Bayrakb, Yıldız Uygunb, Serap Başoğlub Ahmet Demirbasb

aArtvin Coruh University, Department of, Occupational Health and Safety, Artvin, TURKEY bKaradeniz Technical University, Institute of Science, Trabzon, TURKEY

[email protected]

Abstract :

Many compounds consisting of 5-membered heterocyclic rings represent important building blocks in organic and medicinal chemistry. In addition, they are interesting in their own right, due to their pharmacological properties. Therefore, the synthesis of new derivatives of triazoles, thiazoles, and thiadiazoles has been attracting considerable attention for the past few decades [1]. Nalidixic acid (1,8-naphthyridine derivative) was the first synthetic quinolone derivative introduced for the treatment of urinary tract infections in 1963. It is particularly effective against gram-negative bacteria particularly Escherichia coliand resistant to most of the pseudomonasspecies [2]. In the present study, a series of new azoles with substituted nalidixic acid side chains were designed and synthesized as antimicrobial agents.

NN

NHNH2

OO

NN

NH

OO

NHO

NN

NH

OO

NN

O

Cl

NN

NH

OO

NN

O O

NN

O

O

NN

NH

NN

O

N

NHN

O

NN

O

N

NN

O

Cl NO2

i

iiiii

iv v

vi

Scheme 1.i: Benzyl isocyanate, ii: H2SO4 , iii: Ethyl bromoacetate, sodium acetate, iv: 4-Chlorophenacylbromide, sodium acetate, v: NaOH, vi: Na, 1,2-dichloro-4-nitrobenzene

*This study is supported by a grant 8623 and 8663 from BAP of Karadeniz Technical University. References [1] A. Demirbas, D. Sahin, N. Demirbas, S. Alpay- Karaoglu, H. Bektas Turk. J. Chem 34 (2010) 347 – 358. [2] N. Aggarwal, R. Kumar, P. Dureja, J.M. Khurana, Eur. J. Med. Chem 46 (2011) 4089–4099.


86

OR-86 Bio-Synthesis of Cu- Nanoparticles Using Natural Plantcalotropis Extract as Reducing

Agent for Enhanced Antibacterial and Antifungal Activity Muhammad Imran Din

Institute of Chemistry, University of Punjab, Lahore-54590, Pakistan [email protected]

Cell: +92-3007818870 Fax: 92-42-99231269

Herein a green synthetic approach for the synthesis of Copper nanoparticles has been reported. It is simple, efficient, quick and eco-

friendly approach compared to chemical-mediated methods and involves use of plant extract for reduction of metal ions under

ordinary conditions. Calotropisa species of Apocynaceae family, has high medicinal value and rich in polyphenols antioxidant, has

been used for reduction of metal ions. Its extraction is simple and cost-effective and it can reduce the Cu ions easily without

involvement of any external chemical agent. The bio-reduction of Cu nanoparticles was analyzed by UV-Vis spectrometer and

further characterized by FTIR and SEM as a function of time and concentration. FTIR results showed that the organic materials

present inside the extractacts as capping agent as well. The synthesized Cu nanoparticles were uniform and elliptical shape with

average diameter 40 nm. These nanoparticles were active against both gram positive and negative bacteria (Escherichia coli,

Staphylococcus aureus) and fungi (Candida albicans), indicating their broad spectrum antibiotic and antifungal ability.

Keywords:Copper nanoparticles, Green synthesis, Antimicrobial activity,


87

OR-87 Silver(I)-N-Heterocyclic Carbene Catalyzed Multicomponent One-pot Reactions: a

Facile Synthesis of Highly Functionalized Pyrrole-3-carbonitriles Srinivas Nerella

Department of Chemistry, Government Degree College, Jammikunta, SatavahanaUniversity, Telangana State, India-505122

Abstract: Herein we report a facile one pot synthesis of multisubstituted pyrroles from a multicomponent reaction

1 involving aromatic aldehyde, 3,4-

dichloro isonitrile, malononitrile and secondary amine catalyzed by Silver (I) N-Heterocyclic carbene2. The reaction produced high yields of

fuctionalized pyrroles in less reaction time at room temperature in eco-friendly ethanol. Our approach could be an efficient alternative to the reported synthetic methodologies of substituted pyrroles, depending on the availability of starting materials. The products were characterized

by Elemental Analysis, IR, UV-Visible, 1H-NMR, Mass and

13C-NMR spectra.

Figure 1. Scheme showing the synthesis of functionalized pyrrolesviaMulticomponentreaction

References

1. V.Estévez, M. Villacampa, J. C. Menéndez; Chem. Soc. Review.2013, 43, 4633-4657 2. G.abbiati, E. Ross; Beilstein J. Org.Chem.2014,10,481-513

88

OR-88 Synthesis and Evaluation of Antitumor Activities of Novel Fused Uracil Derivatives

Samar A. El-Kalyoubi, Eman A. Fayed

Department of Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt

Email: [email protected]

Abstract A simple and one-pot cyclocondensation reaction of 6-aminouracils and ninhydrin and/or isatin in presence of catalytic amounts of glacial acetic acid for the synthesis of indenopyrrolopyrimidines and indolopyrrolopyrimidines respectively is described. On the other hand, 6-aminouracils undergo nitrosation followed by reduction to obtain 5,6-diaminouracil derivatives. The latter compounds have been used as a direct starting material for the preparation of indenopteridinesand indolopteridines via the reaction with ninhydrin and isatin respectively. All the new synthesized compounds have been characterized by elemental analyses, IR, 1H-NMR spectra and Mass spectral studies.New compounds indenopyrrolopyrimidines, indolopyrrolopyrimidines, indenopteridinesand indolopteridineshave beensynthesized and their in vitro anticancer activities against HepG2 cell line have been evaluated. These compounds exhibited good anticancer activities towards HepG2 cell line. Compounds 10 and 19 with an IC50 of 12.3 μg/ml and 13 μg/ml respectively were found to be the

most active. .

N

N

NH

OO

X

OH

OH

R

R1

N

N

NH

O

X

OH

OH

R

R1

NH

N

N

NH2

O

X

R

R1

1 4-6 7-9

N

NN

N NH

O

X

R

R1

N

NN

NH2NHO

O

X

R

R1

N

NN

N

O

X

O

R

R1

10-14 15-17 18,19

89

OR-89 Comparison of Cold and Hot Esterification Methods of Fatty Acids for GC-MS Analysis

MuhammetDEMİRELa, ZekiAYDINa,SelvinUSTABAŞa

aDepartment of Chemistry,Faculty of Art and Science, Mustafa Kemal University,Hatay , Turkey [email protected]

Abstract: In this study, effect of A and B esterification methods on GC-MS chromatograms were investigated.

Amount of fat for esterification was optimized for both methods and obtained GC-MS chromatograms were compared with each other.

Investigated methods are; i) the first method, 20-60milligrams of fat was taken and put into a glass tube and 1,5 ml 0,5N KOH in methanol was added. Thelid of glass tube was closed and the tube was heated for 7 minutes at 115 0C and cooledat 40 0C. 2 ml (%14) methanolic BF3 mixture was added. The tube was capped tightly and re-heated at 110 0C along 5 minute. Then the mixture was cooled about 40 0C, fatty acid methyl esters were extracted with 2 ml of isooctane. 1,5 ml of isooctane with fatty acid methyl esters was took and mixture was full in vial of GC.[1]

ii)The second method, 20-60milligram of fat was taken and put in to 15 ml falcon tube. 1,5 ml (2 N) methanolic KOH was added tube and shaken . 6 ml n-heptane was added mixture and shake with vortex and it was centrifuged. The supernatant was taken with pipette and filled up in vial of GC.[2]

Then the methods compared with time and convenience, the second method looks more advantageous but we investigated which method produces the chromatograms of the highest quality the other purpose of this study is to detect how much fat need for optimum esterification for both methods. References

1.Kayim, M., ÖKSÜZ, A., ÖZYILMAZ, A., Kocabas, M., Can, E., Kizak, V., &Ates, M. (2011). Proximate Composition, Fatty Acid Profile and Mineral Content of Wild Brown Trout (Salmotrutta sp.)From Munzur River in Tunceli, Turkey. Asian Journal of Chemistry, 23(8), 3533-3537. 2. ISO, 1978. Animal and vegetable fats and oils-preparation of methyl esters of fatty acids. Method ISO 5509.

90

OR-90 Cr(VI) RemovalfromAqueous Solutions byActivatedCarbonPreparedfromGrapeStalk

Mehmet ERDEM, Özlem AKÇAKAL, Hatice ERDEM, Mehmet ŞAHİN

Department of Environmental Engineering, Fırat University, 23279 Elazığ, Turkiye

Abstract

Chromium and its compounds have many industrialuses, such as alloying, electroplating, leather-tanning, corrosion prevention etc. As a result of unregulated applications and inappropriate waste-disposal practices,chromium contamination of surface and ground waterhas become a significant environmental problem.

There are two main treatment methods for Cr(VI) removal. The first type of methods aim to remove Cr(VI) anions directly while the second type is based on the reduction of Cr(VI) to Cr(III). In the last few decades, alternative methods such as adsorption, ion exchange and membrane techniques have received more concern for pollutant removal from waste streams. Since adsorption methods seem to be promising, attention has been focused on chromate adsorbents, which leads to remove hexavalent chromium in one step.Activated carbon is the most widely used material in industrial scale as an adsorbent. Therefore, the demand for activated carbonis also increasingday by day. Activated carbon is relatively expensive product and its cost depends on the raw material, activation method and operational conditions used in its preparation. The cost generally limits widespread use of the activated carbon. In order to reduce the cost of the activated carbon, nowadays, biomasses such as agro-based by-products, wastes or residues are getting increased attention all over the world. Particularly, agricultural by-products or residues have proved to be promising raw materials for the production of activated carbons due to their low cost, abundant and readily available.

Starting from the point mentioned above, in this study, activated carbon obtained from the grape stalk by ZnCl2 activation for removal of Cr(VI) from aqueous solution was used as an adsorbent and Cr(VI) removal from aqueous solutions by adsorption was investigatedas a function of pH, contact time, adsorbent dosage, initial Cr(VI) concentration and temperature. It has been determined that the adsorption of Cr(VI) onto activated carbon is pH dependent.The maximum adsorption yield (88.1 %) was obtained by using the activated carbon at the conditions of pH 2, activated carbon dosage of 1.5 g/l, contact time of 30 min, for the initial Cr(VI) concentration of 25 mg/l and temperature of 25°C.

References

1. G.M. Walker, L.R. Weatherley, Process Saf. Environ., 78, 2000,219-223. 2. D. Savova, E. Apak, E. Ekinci, F. Yardim, N. Petrov, T. Budinova, M. Razvigorova, V. Minkova,

Biomass Bioenerg., 21, 2001,133-142. 3. I. Ozdemir, M. Şahin, R. Orhan, M. Erdem, Fuel Process. Technol., 125, 2014, 200-206. 4. R. Aravindhan, J. Raghava Rao, B. Unni Nair, J. Hazard. Mater., 162, 2009,688-694. 5. Sittig, M., Pollution removal handbook, Noyes Data Corp., England, 1973. 6. Patterson, J.W., Industrial wastewater treatment technology, Butherworths Publishers, Stoneham, MA, 1975.

91

OR-91 Utilization of Bergama Gold Tailings as an Additive in the Mortar

Kubra KUNTa, Meral YILDIRIMa,FatmaDURa, Emek MOROYDOR DERUNa, SabriyePISKINa aDepartment of Chemical Engineering,Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, TR-34210,

Istanbul, Turkey Abstract: Bergama is the first gold mine in the history of Turkish Republic and currently one of the operating gold mine in Turkey. About 3 tons of gold and equal amounts of silver are mined each year. The estimated ore reserves at the Bergama gold mine are 2.4 million tonswith about 10 g Au per tonne of ore. About 277.882 tons of the tailings slurry of gold mine treatment is produced every year during the recovery of gold. Increasing amounts of tailings slurry cause a problem in large disposal areas.Therefore, the recycling of this kind of slurries into useful materials is quite important in terms of economic and environmental aspects. The aim of this study was the investigation of utilization of the gold tailings as an additive material in Portland cement production. For this purpose, the effects of the gold tailings on the compressive strength properties of Portland cement were investigated. Cement mortars were prepared with Portland cement (CEM I 42,5 N) and dried gold tailings. Gold tailings with different ratios (5, 10, 15, 20, 25%) were added as cement additive in the mortar. The fresh properties of mortar such as consistency and setting time were investigated by using Flow table and Standard Vicat apparatus. The mortars were tested for compressive strength values after 3, 7 and 28 days according to the Turkish Standard (TS EN 196-1). Mineralogical composition and microstructure of the 28-day mortars were determined by X-ray diffraction (XRD) and scanning electron microscope (SEM).According to results, it can be concluded that the tailings are eligible for mortar aggregate and the optimum ratio of gold tails is 5%.

References

1. A.A. Mahmood, C.N. Mulligan, Proceedings of the Annual International Conference on Soils, Sediments, Water and Energy, 2007, 12(11), 107-117. 2. L.Widojoko, H.Hardjasaputra, Susilowati, 2nd International Conference on Engineering and Technology Development (ICETD 2013), 2013,8-17. 3. M.S.Yilmaz, S.Pişkin, International Journal of Chemical, Environmental & Biological Sciences (IJCEBS),2013, 1(2), 211-213.

92

OR-92 The Investigation of the Element Contents in the Turkish Coffees

Nigar SELVI, A.Seyhun KIPÇAK a, FundaDEMİRa, Özgül D. ÖZDEMİR a,Mehmet B. PISKINb, Emek M. DERUN a aDepartment of Chemical Engineering, Davutpasa Campus, YildizTechnical University, 34210 Esenler, Istanbul, Turkey

Abstract: Coffee is one of the most popular drinks across the world and its enormous commercial and social importance is obvious. Coffee has become the essential consumption matter and one of the rituals of many societies for several years.

Turkish people's first confrontation with it dates back to 16th century, in Ottoman era. Since then, because of the differences in terms of preparation and presentation styles, the coffee has been named as “Turkish Coffee”. According to this presentation style, roasted and then finely ground coffee beans are boiled in a pot, usually with sugar, and served in a cup where the grounds are allowed to settle.

Turkish coffee contains many components such as caffeine, flavonoids, phenolic compounds and minerals. There are many elements in the structure of the Turkish coffee and have various effect on human health.

In this study, determination of magnesium (Mg),iron (Fe) and calcium (Ca) contents in Turkish coffee aimed for conscious consumption. Inductively coupled plasma optical emission spectrometry (ICP-OES) was used for these analysis. From the results of experiments Mg, Fe and Ca contents were found in Turkish coffee as 21.46, 0.008 and 78.48 respectively. Element contents which are found in 1, 2 and 5 cups of coffee are calculated. Furthermore, the daily intake of element from coffees that affects human health is also investigated.

References

1. B. Cohen; BBC - Travel: Food & Drink. Retrieved 2014, 07-24. 2. R.M. Alonso-Salces, F. Serra, F.Reniero, K.Herberger, J. Agric; Food Chem.2009, 57, 4224–4235. 3. M. Argan, M. Akyildiz, B. Ozdemir, A. Bas, E. Akkus; International Journal of Health and Economic Development,2015, 1(1), 26-36.

93

OR-93 Microwave Dehydration Behaviour of Inderiteand Comparison withThermal Analyses

Methods

Iklim N. OZDOGANa, Yasemen T. AKSOYa, F. TugceSENBERBERa, A. SeyhunKIPCAKa, Mehmet B. PISKINb, EmekMOROYDOR DERUNa aDepartment of Chemical Engineering, Faculty of Chemistry and Metallurgical, Yildiz Technical University, TR-34210, Istanbul, Turkey

bDepartment of Bioengineering,Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, TR-34210, Istanbul, Turkey

Abstract: Dehydration is called as the water removal from hydrated structure. Dehydration behaviour is important for the usage areas andtransportation of minerals. Magnesium borates can be used asadditive materials in areas such as in the production ofsuperconducting materials, in the composition of detergents, due tothe content of boron in the friction-reducing additives in oils andinsulating coating compositions due to their good mechanic andthermal properties. In this study, dehydration behaviour of inderite (Mg(B3O3(OH)5).5H2O)was experimented by bothusing microwave energy different and thermal analyses techniques. In microwave dehydration, power levels were selected as360, 600 and 800W. Mass loss and drying rates were determined for each power level. In thermal dehydration, hydrated mineral was applied to thermal analysis (TG-DTG).Structural changes ofhydrated and dehydrated samples werecharacterized using the techniques ofXRD and FT-IR. XRD results show that crystallinity of sample may decrease in microwave dehydration. According to FT-IR results,characteristic band values of water disappeared at the end of the dehydration.

References

1. Y. Saito, K. Kawahira, N. Yoshikawa, H. Todoroki, S. Taniguchi, Journal of the Iron and Steel Institute of Japan. 2011, 51, 878–883.

2. S. Sener, G. Ozbayoglu, S. Demirci, Thermochimica Acta, 2000, 362, 107-112. 3. S. Li, X. Fang, J. Leng, H. Shen, Y. Fan, D. Xu, Material Letters. 2010, 64, 151-154. 4. E.M. Elssfah, A. Elsanousi, J. Zhang, H.S. Song, C. Tang, Material Letters. 2007, 61, 4358-4362. 5. L. Zhihong, H. Mancheng, G. Shiyang, Journal of Thermal Analysis and Calorimetry. 2004, 75, 73-78. 6. L. Zhihong, H. Mancheng, ThermochimicaActa.2004, 411, 27-29.

94

OR-94 Utilization of Boron Waste as an Additive for Cement Production

Kubra KUNTa, Fatma DURa, BerilERTINMAZa, Meral YILDIRIMaEmek MOROYDOR DERUNa, Sabriye PISKINa aDepartment of Chemical Engineering, Faculty of Chemical and Metallurgical Engineering, Yıldız Technical University, TR-34210,

İstanbul, Turkey [email protected]

Abstract: Turkey has 864500 thousand tones B2O3reserves which are 72.1% of the world [1]. The most important boron minerals in Turkey are colemanite (Ca2B6O11.5H2O), ulexite (NaCaB5O9.8H2O)and borax (tincal) (Na2B4O7.10H2O). To be able to obtain different kinds of borates and boric acid, these minerals are concentrated. While carrying out concentration processes some wastes that include boron form which should be recovered because wastes that contain boron cause environmental pollution such as soil and water pollution. With recovering, economical contribution is also achieved. One of the boron wastes that forms while boric acid production from the reaction between colemanite ore and sulphuric acid is borogypsum. In this study borogypsum which is produced in Bandırma Boron Plant, Turkey was used as cement additive in two different forms. To investigate influence of calcination process of borogypsum on the properties of cement mortar, different amounts of both calcined and non-calcined waste (between %1 and %10) was added to clinker. The fresh properties of mortar including consistency and setting time were investigated by using Flow table and Standard Vicat apparatus. The compressive strength of mortars were tested for 3, 7 and 28 days of curing according to the Turkish Standard (TS EN 196-1). The chemical composition and microstructure of the 28-day mortars were analysed by X-ray diffraction (XRD) and scanning electron microscope (SEM). According to results, for both calcined and non-calcined borogypsum the optimum waste ratio is 3% when at this ratio the compressive strength of mortar of containing calcined borogypsum is higher.

References

1. http://www.etimaden.gov.tr/bor-rezervleri-72s.htm 2. U. K. Sevim, Y. Tümen; Construction and Building Materials. 2013, 48, 342-347. 3. U. K. Sevim; Materials and Structures. 2011, 44, 187-193. 4. İ. B. Topçu, A. R. Boğa; Waste Management & Research.2010, 28, 626-633. 5. M. Özdemir, A. Uğurlu; Materials and Manufacturing Processes, 2011, 26, 1130-1135. 6. E. M. Derun, İ. Y. Elbeyli, N. Tuğrul, S. Pişkin; 8th International Conference on Environmental Science and Technology.2003 7. T. Kavas, A. Olgun, Y. Erdoğan; Cement and Concrete Research. 2005, 35, 711-718.

95

OR-95 New Approach to Modelling of Discontinuous Azeotropic Distillation in Non-

Conventional Configurations Marija Stojkovic

National Polytechnic Institut Campus , Laboratory of Chemical Engineering INP-ENSIACET,Group for process and system engineering (PSI ), University of Toulouse ,

F-31432 Toulouse cedex 4 , Republique de France Abstract: 1.Modelling the simple batch distillation with reaction The aim of the modelling of simple batch reactive distillation is to obtain the column profile , similar to the Residue Curve Maps . This work has already been done by Doherty and co-workers ([1],[2],[3]) . Doherty team’s worked on two-phase systems (V/L) , as Sundmacher ‘s worked usually with three-phase systems (V/L/L). One of the main’s conclusions of the Doherty’s teams , that it is worth to transform ([1],[2]), to transform the compositions in the case of chemical equilibrium . With the offered transformation a forth component system with one equilibrium reaction will be presented in 2D. The phase –plane is square and the pure components are vertexes of the square . Another important conclusion is that differential equations describing the composition change in the still are non-autonomous and therefore calculated still paths will intersect each others ([3]). The shape of these paths depends on the heating policy and other conditions. The easiest way to investigate simple batch reactive distillation , is the case when vapor flowrates changes along with the liquid hold-up in the still (nearly constant Da number during the process). Another possibility is to keep Da number on a constant value, and that would be the application on heterogeneous catalyses instead of homogeneous. The Sundamcher’s team worked with possibility in the V/L/L systems , therefore they faced not the problem of non-autonomous equations. 2. Modelling and simulating batch distillation with reaction For modelling of simple batch distillation with reaction , similar as for continuous one equilibrium and non-equilibrium model can be applied as well. Maybe the most important review on this work is -Krishna article ([5]), but Noeres et al ([6]) also worked in the same spirit. 3.Feasibility of the batch distillation with reaction The studies with column profiles with chemical reaction included can be applied([1]-[4]), and I will made a reference on an article that works specially on the movement of still composition during batch reactive distillation ([7]).

References

[1] Barbosa-Doherty, Chem. Eng. Sci., 1988, 529- [2] Barbosa-Doherty, Chem. Eng. Sci., 1988, 541- [3] Venimadhavan et al., AIChEJ, 1994, 1814- [4] Zhiewen-Sundmacher, Comp. Chem. Eng., 2002, 1459- [5] Taylor-Krishna, Chem. Eng. Sci., 2000, 5183- [6] Noeres et al, Chem. Eng. Proc., 2003, 157- [7] Gadewr et al, Ind. Eng. Chem. Res., 2000,

96

OR-96 About Evaluation in Chemistry Education

Meliha Zejnilagić-Hajrić Faculty of Science, University of Sarajevo, Zmaja od Bosne 33-35,71000 Sarajevo, Bosnia and Herzegovina, [email protected] Abstract: Evaluation needs to be continuous process and students should perceive it as such, as a way of teaching and a way of keeping students development. Therefore, any kind of assessment should not make students afraid or anxious. This paper presents results of a research conducted among 580 primary school students (7th and 8th grade) and nine chemistry teachers, in order to get insight in their perception of evaluation in chemistry education. We have compared students’ and teachers’ opinions in two cantons in Federation of Bosnia and Herzegovina using comparable questionnaires for students and teachers designed for the purpose of this study. Results show that every teacher has its own way of assessing her/his students, that performing an experiment, if performed at all, mostly does not affect students’ mark. However, knowledge is not the only factor that has influence on the mark in chemistry, but the overall students attitude towards chemistry and her/his entire personality. Students’ competencies and skills mostly do not affect the mark as well. Differences in students’ and teachers’ responses between cantons were not significant. We recommend changing the way that teachers evaluate their students in chemistry and assign marks in order to include skills and competencies for performing an experiment. Further research should be conducted in order to evaluate outcomes of teaching process and therefore to make some changes in evaluating both students and teachers. The purpose of evaluation should be a contribution to students ’ progress and a tool for increasing students’ motivation for learning and for gaining better results.


97

OR-97 The Use of Mathematical Softwares in Chemistry Education

Mehmet YALÇINa, Fatma AĞGÜL YALÇINa, , Halil ZEHİRa and Kıymet ZEHİRa

aDepartment of Primary Education, Agri Faculty of Education, Agri İbrahim Cecen University, TR-04000

Agri,Turkey Abstract:

In this study, in chemistry education,some applications of Mathcadsoftware were examined. The rates of

chemical reactions are widely studiedtwo models: rate-determining step approach and steady-state approach.

Understanding the applications of these models is essential for the teaching of these subjects. In the current

study, using Mathcad program,kinetics modeling ofsome reactions was examinedaccording to the two models.

The parameters in the model were calculated and plotted related graphics. The findings of this study are

believed to provide the examples that can be used in middle and high school levels.

98

OR-98 Corrosion Inhibition of Low Carbon Steel by Boron-Containing Ionic Liquids in 0.1 M

HCl* Husnu GERENGIa, H.Ibrahim UGRAS, Mine KURTAYa, Necip ATARc

aCorrosion Research Laboratory, Kaynasli Vocational College, Duzce University, 81900 Kaynasli, Duzce, Turkey bDepartment of Chemistry, Faculty of Sciences, Duzce University, 81620 Duzce, Turkey

cDepartment of Chemical Engineering, Faculty of Engineering, Pamukkale University, Denizli 20070, Turkey

Abstract: Among various methods to avoid or prevent destruction or degradation of metal surface, the corrosion inhibitor is one of the best known and the most useful methods of corrosion protection in industry. Environmental concerns are pushing forward the studies, aiming to develop new inhibitors, so green and film assembling inhibitors have been frequently investigated. The aim of this research is to investigate the inhibition effect of 1-Ethyl-1-methylpyrrolidinium tetrafluoroborate as a corrosion inhibitor towards the corrosion of low carbon steel in 0.1 M HCl solution at room temperature using Tafel polarization method. Results showed that 1-Ethyl-1-methylpyrrolidinium tetrafluoroborate was an anodic inhibitor and its inhibition efficiency increased with the inhibitor concentration.

Scheme1. Tafel curves for low carbon steel in 0.1 M HCl in absence and presence of inhibitor.

*This study is supported by a grant (Project Number: 114M933) fromScientific and Technological Research Council of Turkey (TÜBİTAK),

References

1. P. Slepski, H. Gerengi, A. Jazdzewska, J. Orli, K. Darowicki, Constr. Build. Mater., 2014, 52, 482. 2. H. Gerengi, C. Tascioglu, C. Akcay, M.Kurtay, Ind. Eng. Chem. Res., 2014, 53(49), 19192. 3. H. Gerengi, A. Jazdzewska, M. Kurtay, J. Adhes, Sci.Technol.,2015, 29, 36.

99

OR-99 Investigation Corrosion Effect of KBF4 on Low Carbon Steel by Dynamic Electrochemical

Impedance Spectroscopy (DEIS) * Husnu GERENGIa, H.Ibrahim UGRAS, Mine KURTAYa

aCorrosion Research Laboratory, Kaynasli Vocational College, Duzce University, 81900 Kaynasli, Duzce, Turkey bDepartment of Chemistry, Faculty of Sciences, Duzce University, 81620 Duzce, Turkey

Abstract: KBF4 is a key ingredient in "Boronizing" of steel. It changes microstructural characterisation and hardness of metals. Thus it is used in applications in which wear resistance is important, such as in oil and gas fields and drilling equipment. In this research, the corrosion effect of KBF4 on carbon steel corrosion was investigated by dynamic electrochemical impedance spectroscopy (DEIS) technique. The results obtained showed that the corrosion rate of low carbon steel increases with increasing concentration of KBF4 .

Scheme1.DEIS result of low carbon steel in 0.04 M KBF4.

*This study is supported by a grant (Project Number: 114M933) fromScientific and Technological Research Council of Turkey (TÜBİTAK),

References 1. H. Gerengi, G. Bereket,Prot. Met. Phys. Chem,2012, 361-366. 2. H. Gerengi, P. Slepski, E. Ozgan, M. Kurtay, Mater. Corros.,2015, 66(3), 233-240. 3. H. Gerengi, A. Jazdzewska, M. Kurtay, J. Adhes. Sci. Technol.,2015,29(1), 36-48.

100

OR-100 Removal of Endocrine Disrupting Chemicals in Aqueous Solutions by Gamma-irradiation

MasoomehMEHRNIA, SinemDEMİR, Murat TORUN, DilekŞOLPAN Department of Chemistry,Hacettepe University, TR-06800, Ankara, Turkey

[email protected]

Abstract: Endocrine disruptors are chemicals that may interfere with the body’s endocrine system and produce adverse

developmental, reproductive, neurological, and immune effects in both humans and wildlife. Radiation technology seems to be the most efficient method to remove such compounds from surface and drinking waters.In this study,dimethylphtalate(DMP) in water was removed with AOP’s based on gamma-irradiation. The degradation of DMP and the effect of hydrogen peroxide on gamma-irradiation were followed by using UV-Vis spectrophometer and high performance liquid chromatography (HPLC) as a function of irradiation dose.İnitial concentration of DMP was 25 mg/L. Aqueous solutions of DMP wasirradiated in gammacell 220 60Co-gamma sourcewith a dose rate of 0.026 kGy/h. In order to increase the efficiency of degradation of DMP and intermediates which may be toxic, H2O2 was used as hydroxyl radical (oxidizing agents) sources in addition to water radiolysis products.For degradation of DMP and intermediates the additional experiments were performed in order to optimize conditions for using H2O2 and ozonation (H2O2 concentration, ozonation time). In the absence and presence of H2O2 and O3 after and before irradition the amounts of dissolved oxygen and formaldehyde were determined by using oxygen meter and UV-vis spectrometer, respectively.Residual DMP concentration and % removal efficiency values were calculated. It was found that the degradation of DMP was increased with the irradiation dose. The decrease in the pH oftheaqueous solutions of DMP with the irradiation dose was observed. The irradiation doses necessary for complete degradation of 25 ppm requiredtocompletelydegradationof DMP waslower in the presence of hydrogenperoxide. 100% of DMP can be removed at the 1.7 kGy irradiation dose in the presense of 4.8mM hydrogen peroxide. The concentration of hydrogen peroxide is effective in the degradation of DMP. the combined gamma/H2O2 process could effectively degraded DMP, which is attributed to the strong oxidation strength of hydroxyl radical produced. Results show that DMP degradation rate was affectedby H2O2concentrationandirradiationdose. References

1.S.Esplugas, D.M.Bila, L.G.T.Krause, M.Dezotti;Hazardous Materials.2007,149, 631–642. 2.X.Kun Zhao, G.Peng Yang, Y.Jue Wang, X.Chi Gao; Photochemistry and Photobiology A: Chemistry.2004,161 , 215–220. 3.M.T.Orbey,N.Günden, N.Ertas; Analitikkimyapratikleri, GaziÜniversitesiEczacılık Fakültesi, Ankara, 2012.


101

OR-101 Synthesis of BisbenzoinEnd-FunctionalizedPoly(-Caprolactone) Macrophotoinitiatorand

Its Use in Miktoarm Star Copolymerization Zafer Uyar, ÜlküARSLAN,Mustafa Degirmenci

Harran University, Science Faculty, Department of Chemistry, Şanlıurfa 63190, Turkey [email protected]

Abstract:

A new well-defined bisbenzoin group end-functionalized poly(-caprolactone) macrophotoinitiator (PCL-(PI)2) was synthesized by

combination of ring opening polymerization (ROP) and click chemistry. The ROP of -CL monomer in bulk at 110 0C, by means of a hydroxyl functional initiator namely, 3-cyclohexene-1-methanol in conjunction with stannous-2-ethylhexanoate, (Sn(Oct)2), yielded a well-defined PCL with a cyclohexene end-chain group (PCL-CH). The bromination and subsequently azidation of the cyclohexene

end-chain group gave bisazidofunctionalzedpoly(-caprolactone) (PCL-(N3)2). Acetylene functionalized benzoin photoinitiator (PI-alkyne) was synthesized by using benzoin and propargyl bromide. Then the click reaction between PCL-(N3)2 and PI-alkyne was

performed by Cu(I) catalysis. The spectroscopic studies revealed that low-polydispersitypoly(-caprolactone) with bisbenzoinphotofunctional group at the chain end (PCL-(PI)2) was obtained.This PCL-(PI)2macrophotoinitiator was used as a precursor in photoinitiated free radical promoted cationic polymerization to synthesize a miktoarm star copolymer consisting of

poly(-caprolactone) (PCL, as A block) and poly(cyclohexene oxide) (PCHO, as B block).

Figure 1.Bisbenzoin End-Functionalized Poly(-Caprolactone) Macrophotoinitiator

References

1. M. Degirmenci, M. A. Sarac, N. Genli, Polymer Bulletin.2014, 71(17) 1743–1755. 2. M. Degirmenci, P. AtukBesli, N. Genli;Journal of Polymer Research.2014, 21(9), 540.

Keywords: Ring openingpolymerization (ROP); Click chemistry; Photoinducedfreeradicalpromotedcationicpolymerization; miktoarmstarcopolymer

102

OR-102 Synthesis and Photochromic Properties of 4,5-Bisaryl-3(2H)-Pyridazinones

Leyla Gundogdua, Ersin Orhanb and Mahmut Kosea

aDepartment of Chemistry, Faculty of Arts and Science, Bülent Ecevit University, 67100, Zonguldak, Turkey, E-

mail: [email protected] or [email protected]

bDepartment of Chemistry, Faculty of Arts and Science, Düzce University,81620, Düzce, Turkey

Abstract:

X

S S

XMe

Me R2

NNO

R1= H, Me, Ph; R2= Me, Ph; X= C, N

R2

X

S S

XMe

Me

NNO

R2 R2

R1R1

Open-ring form (O-form) Closed-ring form (C-form)

hv1

hv2

Photochromism can be defined as the reversible color and absorption spectral change of a molecule [1]. Thermally stable and fatigue resistance photochromic compounds have some possible industrial applications including, color changing lenses (such as sun glasses), actinometry, optical memory systems, molecular-level switches etc. Diarylethenes [2] are well known photochromic compounds that show color change via electrocyclic reaction.In this work, photochromic bisarylpyridazinones containing2,5-dimethylthiophene or 5-methyl-2-phenylthiazole unit were synthesized, and their photochromic and fluorescence properties were investigated.The closed-ring forms of bisarylpyridazinones were displayed negative solvatochromism. The bisarylpyridazinones shows fluorescence at 400-480 nm on excitation at 302 nm, and the intensities of emission bands gradually decreased during the ring-closure photoreaction. Among the synthesized bisarylpyridazinones, 4,5-bis(5-methyl-2-phenylthiazol-4-yl)-2-methyl(or 2-phenyl)(pyridazin-3(2H)-ones (5O and 6O) displayed larger absorption and emission spectral change, higher quantum efficiency during the photoreaction compared to the others. A high conversion ratio (94%) was also observed for 5O. *The authors are grateful to Turkish Council of High Education and TUBITAK (Scientific and Technical Research Council of Turkey) (Grant No.: 113Z547) for the financial support of this work. References [1] H. Durr, H. Bouas-Laurent (eds.), Photochromism: Molecules and Systems. Elsevier, New York, 1990, pp. 15-25. [2] M. Irie, Diarylethenes for memories and switches,Chem. Rev., 2000, 100, 1685-1716.



103

OR-103 Antioxidant and Anticholinesterase Activity Evaluation of Various Fraction of

Sarcosphaera crassa (Santi) Pauzar: A Poisonous Edible Mushroom Zain Ullah, Mehmet Öztürk,Mehmet Emin Duru, Yunus Cetintas

Department of Chemistry, Faculty of Sciences, Muğla Sitki Koçman University, Kötekli-48000, Muğla, Turkey

Abstract Most of the mushrooms, which are poisonous, are not consumable by humans. Interestingly they can be converted to non-poisonous by just cooking. Sarcososphaera crassa is a poisonous mushroom and it was decided to make it usable somehow. For this purposeS. crassa was divided in two parts: cooked and uncooked and both were extracted by petroleum ether, acetone, methanol and water. Obtained fractions were submitted to antioxidant activities i.e. DPPH free radical scavenging activity, ABTS cation radical, β-carotene-Linoleic acid and anticholinesterase activities. Literature surveys are very limited, only our group has some studies to related work (Ozturk et al, 2009, 2011, and 2011). Acknowledgements Authors are thankful to TUBITAK for financial support with Project number: TUBITAK-KBAG-114Z635and Graduate Scholarship Programme for International Students TUBITAK-BIDEB-2215).

References

1. A. L. Ertas, M. Ozturk, M. Boga, G. Topcu, Antioxidant and Anticholinesterase Activity Evaluation of ent-Kaurane Diterpenoids from Sideritis argute, J. Nat. Prod. 2009, 72, 500–502.

2. M. Ozturk, M. E. Duru, S. Kivrak, N. M. Dogan, A. Turkoglu, M. A. Ozler, In vitro antioxidant, anticholinesterase and antimicrobial activity studies on three Agaricusspecies with fatty acid compositions and iron contents: A comparative study on the three most edible mushrooms, Food and Chemical Toxicology, 2011, 49, 1353–1360.

3. M. Ozturk, U. Kolak, G. Topcu, S. Oksuz, M. Iqbal Choudhary, Antioxidant and anticholinesterase active constituents from Micromeria cilicicaby radical-scavenging activity-guided fractionation, Food Chemistry, 2011, 126, 31–38.

104

OR-104 Biological Activities and Chemical Composition of Essential Oil of Endemic

RhantheriumsuaveolensDesf. from Algerian Sahara Ahmed ElkhalifaChemsab,c, EbruErola, Mehmet Öztürka, Amar Zellaguic,OzgürCeyland, NoureddineGherrafc, Mehmet E. Durua

aDepartment of Chemistry, Faculty of Science, Mugla SitkiKocman University, Mugla, Turkey bDepartment of Biology, Faculty of Life and Natural Sciences, El Oued University, Algeria

cLaboratory of Biomolecules and Plant Breeding, Life Science and Nature Department, Faculty of Exact Science and Life Science and Nature, University of Larbi Ben MhidiOum El Bouaghi, Algeria

dDepartment of Plant and Animal Breeding,Ula Ali Kocman Vocational School, MuglaSitkiKocman University,Mugla, Turkey

Abstract: RantheriumsuaveolensDesf., a member of the Asteraceae (Compositae), is locally known as “Arfadja” which is an endemic desert

plant growing in North Africa(1). Some of the Rhantherium species are used in folk medicine (2).

In this study, the antioxidant, anticholinesterase and antimicrobial activities of the essential oil and methanolextract ofR.suaveolens

were studied. The oil composition was studied using gas chromatography(GC) and gas chromatography mass spectrometry(GC-

MSD).

Twenty-four compounds were detected in essential oil of Rhantheriumsuaveolensand twenty-one of them were identified,

representing 98.01% of the total oil. In β-carotene-linoleic acid assay, both the oil and the methanol extract exhibited good lipid

peroxidation inhibition activity, demonstrating 76.61 ± 2.20% and 92.07 ± 0.27% at 0.2 mg/mL concentration, respectively. In DPPH

and CUPRAC assays, however, the methanol extract exhibited good antioxidant activity. The highest antibiofilm activity has been

found 50.30% against Staphylococcus epidermidis (MU 30)at 20 mg/mL for EO and 58,34% against Micrococcus luteus (NRRL B-

4375)at 25 mg/mL concentration for MeOH extract. The in vitro anticholinesterase activity of MeOH extract showed moderate

acetylcholinesterase inhibitory (IC50 = 168.76 ± 0.62µg/mL) and good butyrylcholinesterase inhibitory (IC50 = 54.79 ± 1.89µg/mL)

activities, while the essential oil was inactive against both enzymes.

References:

1. P.Quezeland, S. Santa, Vol. 2. Paris, France, 1963, 948.

2. C.Hamia, N.Gourine, H.Boussoussa, M.Saidi, E.M.Gaydou and M.Yousfi, NPC, 2013, 8, 1171-117.

105

OR-105 Study of Thermal Behavior of Nanocomposite Base on Aniline and Multi Walled Carbon

Nanotube: Effect of Size Carbon Nanotube on Thermal Stability. Shima moradi seydmohammadi1, omid moradi2

1Shima moradi seydmohammadi [email protected]

2Omid moradi [email protected]

Department Of Chemist, College Of Science, Shahr-e- QodsBranch, Islamic Azad University, Tehran, Iran

Abstract In This Study, A Significant Influence On The Thermal Stability Of Polyaniline In The Presence Of Three Size Multi-Walled Carbon Nanotubes Has Been Investigated. The Shape And Diameter Of The Resulting Nanocomposites And Nanostructured Composites By Scanning Electron Microscopy, Fourier Transform Infrared Spectroscopy Evaluation. However, The Presence Of Nanotubes Significantly Increases The Thermal Stability Of Polyaniline In The Main Building Which Has Been Exposed To Laser Light, Which Can Be A Core-Shell Structure Of Nanocomposites Of Polyaniline Attributed Shvd.Ba Heterogeneous Thermal Behavior It Was Found That Increasing The Size Of The Resulting Nanocomposites With Carbon Nanotubes, The Thermal Stability Increases. Keywords:Multi Walled Carbon Nanotube, Polyaniline, Thermal Stability ,Nanocomposite

106

OR-106 Investigation of Corrosion Behavior of the DP600 Steel and AA5754 Aluminum Alloy

Materials Joined Using Friction Stir Welding Method

Ramazan SAMUR Department of Materials and Metallurgy, Faculty of Technology, Marmara University, TR-34730 Istanbul,

TURKEY Starting with service conditions of the welded metal alloys with dissimilar chemical compositions causes corrosion in industrial applications(1). In this study, the corrosion behavior of AA5754 aluminum alloy and DP600 friction stir welding method joined with duplex steel materials wastested. An AA5754 aluminum alloy sheet with a thickness of 2mm and a steel plate DP600 with a thickness of 1.8 mm were cut into measures of 300x100mm. Accuracy was obtained using the optimal friction stir welding parameters to be joined. In friction stir welding procedure, 20mm diameter shoulder and1.8mm tapered tip height with friction stir welding tool was used. The optimum welding parameters were 1600rev / min and tool rotation speed of 90 mm/ min feed rate. To determine changes in the microstructure and chemical composition of the weld seam formed by bonding, the basematerial was welded and cut. Then the metallographic processes were implemented on weld samples in a manner that characterized weld seam after hot forming. Scanning electron microscope (SEM) micrograph of the microstructure next diffusion (EDS) point and regional chemical composition was determined by analysis(2). The corrosion behavior of the two different materials forming the welded joints in the form of standard size cut to represent weld seam and the core material was tested(3). Thisstudy is supported by Marmara University Research Fund (Projects No: FEN-C-YLP-030114-0014 References

1. Esther T. AKINLABI et al, Trans. Nonferrous Met. Soc. China 24(2014) 1323−1330 2. C.Shen, J. Zhang, J.Ge,Journal of EnvironmentalSciences2011, 23(Supplement) S32–S35 3. Cristiano Padovaniet al, CorrosionScience 53 (2011) 3956–3969

107

OR-107 Catalytic Pyrolysis of Isochrysis Microalgae by Ceria Based Catalysts for Hydrocarbon

Production*

Tevfik AYSUa,b, Aimaro SANNAb

aDepartment of Chemistry, Faculty of Education, Yüzüncü Yil University, 65080, Van, Turkey b Institute of Mechanical, Process and Energy Engineering (IMPEE), Heriot-Watt University, EH14 4AS, Edinburgh, UK


Microalgae for biodiesel suffered from the costly extraction of algal oils (lipids) by organic solvents due to the microalgal different physico-chemical characteristics, such as the cell size and cell wall chemistry.[1]Moreover, only the lipid fraction of microalga is used for biodiesel, while the carbohydrates and proteins are considered as waste. The thermo-chemical conversion (liquefaction, pyrolysis or gasification) pathway instead allows full conversion of the microalgae components to bio-fuels. Recently, pyrolysis has received increasing attention in conversion of lignocellulosic and algae biomass due to its relative low energy consumption and flexibility in terms of plant size. [2]Although microalgae to biodiesel has been studied extensively, microalgae catalytic pyrolysis has received less attention, with studies mainly focusing on the effect of the process variables using acid zeolites, which tend to favour dehydration reactions and formation of aromatics products. [3] In this study, catalytic pyrolysis of Ischrysis microalgae was carried out over ceria based catalysts for the first time in a fixed bed reactor. There was a clear effect of the catalysts on the product yields and quality, with the catalysts able to recover a large fraction of the starting microalgae energy (64-77%) in the bio-oils. Bio-oil yield was found to be higher in presence of Ni-Ce/Al2O3 and Ni-Ce/ZrO2 (26 wt.%). The produced bio-oils had HHVs of 34-37 MJ/kg and suffered strong deoxygenation, with O level decreased from 40-41% in the starting microalgae to 9-15%. Also, 15-20% N removal was obtained using the ceria based catalysts. The oxygen contents in the bio-oils were remarkably lower than those previously obtained using ZSM-5 (25%) and other species without catalyst (17-24%). 1H-NMR and GC-MS analysis showed that the bio-oils were enriched in aliphatics and aromatics and depleted in N-compounds using the ceria based catalysts. *This study was supported by Centre for Innovation in Carbon Capture and Storage (CICCS), Heriot-Watt University (EPSRC Grant

No.EP/F012098/2) and Scientific and Technological Research Council of Turkey (TUBITAK), post-doctoral research fellowship programme, 2219.

References

1. M.J. Paik, H. Kim, J. Lee, J. Brand, Y.R. Kim, J. Chromatogr. A,2009, 1216, 5917–23. 2. G. Belotti, B. De Caprariis, P. De Filippis, M. Scarsella, N. Verdone,Biomass Bioenerg., 2014, 61, 87–

95. 3. S.T. Gopakumar, S. Adhikari, S.A. Chattanathan, R.B. Gupta, Bioresour. Technol.,2012,118, 150–7.


108

OR-108 Proximate, Mineral Composition And Phytochemicals Screening of Some Selected Spices

of Ibadan Metropolis, Oyo State, Southwest, Nigeria *1Adegbola, Rachael Adebola, 2Davies, Caleb Adeosun , 3Abiona, Dupe Lydia

1,3 Chemistry Department, The Polytechnic, Ibadan, P.M.B. 022, UI P.O. Oyo State, Nigeria 2National Horticultural Research Institute, P.M.B 5432, Idi-Ishin, Jericho, Ibadan, Oyo State,

Nigeria *Corresponding Authour: [email protected]

Abstract Spices which are widely used in Southwest Nigeria has aroma, enhance taste of food and posses medicinal values. Proximate mineral composition and phytochemical screening of ten randomly selected spices were carried out. Recommended procedures were used for analysis. Mineral composition was determined using flame photometer, colorimeter and Atomic Absorption Spectrophotometer (AAS).The proximate composition showed that protein was high at 12.04% in Zingiber officinale and low at 2.1% in Xylopia aethiopica. Ocimum gratissimum contain high moisture content at 82.1%, while Tetrapleura tetraptera has the least of 3.5%. High ash content was recorded in Ocimum gratissimum at 13.68% and lowest in 0.98% in Allum cepa. For carbohydrate Allium cepa had the highest value of 78.36%, while Allium setiva had the least value of 19.48%. Mineral composition showed high value of calcium 712mg/100g, magnesium 172.2mg/100g, potassium 868.5mg/100g, sodium 75.85mg/100g, manganese 95.38mg/100g in Allium sativa, Xylopia aethiopica, Momodara myristica, Ocium gratissimum, Tetrapleura tetraptera respectively. Aframomium meleghueta had high value of iron and zinc at 85mg/100g and 97mg/100g respectively and also high presence of alkaloids, glycosides, saponins and tannis. High value of saponnis and triterpenoids were observed in Zingiber officinale and Ocimum gratissimum respectively. This study had shown that spices had greater use in medicine and as food supplement. Key words: Spices, Phytochemical screening, Proximate, mineral composition

109

OR-109 AP-TPR-TD-GC/MS Study of Miocene-aged Lignite Humic Acids, Bulgaria

Maya STEFANOVAa, Lenia GONSALVESH a, Stefan MARINOV a, Jan CZECH b, Robert CARLEER b, Jan YPERMAN b

a Laboratory Fuel Chemistry, Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113

Sofia, Bulgaria b Research group of Applied and Analytical Chemistry, CMK,Hasselt University, B-3590 Diepenbeek, Belgium

Abstract: Atmosphere Pressure–Temperature Programmed Reduction (AP-TPR) technique coupled “off-line”

with thermal desorption gas chromatography-mass spectrometry (TD-GC/MS) apparatus can be effectively used to specify qualitatively/quantitatively organic functionalities in humic substances. The AP-TPR technique has been initially developed and successfully applied for the specification of sulphur species in coals and in their biodesulphurized products. The aim of the present study is to analyze by AP-TPR “off-line” TD-GC/MS volatiles in flue gases of reductive pyrolysis of Miocene-aged lignite humic acids and to relate recorded components to the structural compositions of the samples studied.

Humic acids from two coal-bearing provinces in Bulgaria, i.e. Thrace and Sofia ones, have been considered. In the flue gases from the AP-TPRexperiment the following compounds were tracked and quantified: aliphatics, i.e. nC6÷nC14,mono unsaturated/saturated pairs, alkylated benzenes, styrenes, naphthalenes, biphenyls, fluorene, acenaphthylene; oxygen containing compounds, i.e. phenols, methoxy phenols, furans, benzofurans; sulphur containing compounds, i.e. sulphides, thiophenes, benzothiophenes; nitrogen containing compounds, i.e. pyrroles, indoles, quinolines, benzonitriles, etc.

The following total content of compounds in pyrolysates has been determined: for Thrace humic acids (Maritza-East deposit) – 55.9 mg/g Corg, and for Sofia humic acids (Stanjanci deposit) – 55.0 mg/g Corg; alkyl benzenes (C6÷C10) highly dominated in the pyrograms up to half of the recorded components, 46-58 rel. %. The low sample maturity was reflected in high abundance of phenols, C6÷C8 (20 rel.%), methoxy phenols (2.7 rel.%) and products from carbohydrates degradation, i.e. furaldehydes, 2-cyclopenten-1-ones, etc. Plots of four group composites, i.e. aliphatics, aromatics, O-, S- and N-containing compounds, in “spider web” diagram

seem promising for bulk interpretation of pyrolysates data. According to reductive pyrolysis data, structural units of Miocene-aged humic acids should have been

composed by 1-2 aromatic rings, condensed or coupled, with presence of heteroatoms arranged in linear and cyclic forms.

*This study was supported by BAS-Bulgarian bilateral projects with FWO-Flanders, Belgium.

110

OR-110 Rhizopogonroseolus and Its Bioassay-Guided Mycochemical Investigations

Akhtar Muhammad,a Mehmet Öztürk,a Mehmet Emin Duru,a Aziz Turkoglu,b

a Department of Chemistry, Faculty of Sciences, Muğla Sitki Koçman University, Kötekli-48000, Muğla, Turkey b Department of Biological, Faculty of Sciences, Muğla Sitki Koçman University, Kötekli-48000, Muğla, Turkey Abstract:

Mushrooms are important source of bioactive metabolites for the development of drugs, nutraceuticals and, used in traditional foods and medicines. The research on pharmacologically active constituents of medicinal mushroom has become interesting field for researchers. Some recent studies have pointed out the important biological activities such as antitumor, anticancer, antioxidant, antipyretic, anti-Alzheimer, antimalarial, antiinflammatory, and antiimmunomodulatory etc. 1

Rhizopogon is a genus of 150 species. 2 Most of the species of this genus have been consumed as food since long times by the peoples of Anatolia. Many species of this genus have been studies for their mycochemicals and commercial uses but interestingly, Rhizopogonroseolus is not discovered –although it grows in collectable and researchable amounts.

We have fractionated the crude extract of R. roseolus in hexane, acetone and methanol. Initial investigations showed all the fractions are active in antioxidant studies. In addition to it, supernatant and polysaccharides fractions were also investigated.

In conclusion, exploration of the mycochemistry of R. roseolus and further exploration of biological activity studies will be helpful to bring safer and better natural products into food industry.

*The authors would like to thank to TUBITAK for support i.e. Research Fellowship Programme for Foreign Citizens programmes TUBITAK-BIDEB-2216 for project &TUBITAK grant number MHRS-114Z635.

References:

1. Tong H; Xia N; Feng K; Sun G; Gao X; Sun L; Jiang R; Tian D; Sun X. Bioresource Technol.2009, 100, 1682-1686.

2. Iwan Ho and James M. Trappe, Mycology, 1987, 79(4), 553-558.

111

OR-111 Investigation of Leaching Performance of Wood Materials Colored With Juglans Regıa L.

Osman GÖKTAŞa, Ertan ÖZENa, Mehmet YENİOCAKa, Mehmet ÇOLAKa,

Mehmet UĞURLUband SEVİL YENİOCAKa

a. Muğla Sıtkı Koçman Unıversıty, TechnologyFaculty, WoodworkingIndustrial Engineering,48000 Kötekli / MUĞLA / TURKEY

b. Muğla Sıtkı Koçman UnıversıtyFaculty of Science, Department of Chemistry 48000 Kötekli / MUĞLA / TURKEY

Abstract

The purpose of this study to develop an eco-friendly wood stain alternative to synthetic dyes and to determine the adsorption and desorption on surfaces. For thispurpose; wood blocks was prepared from Turkish oriental beech (FagusorientalisLipsky), Scots pine (Pinussylvestris L.) , oak (Quercus petraeaspp), and walnut (Juglonsregia L.). Plant dyestuff was extracted from theJuglansRegia L. by using ultrasonic assisted method. For mordants, ferrous sulfate(Fe2(SO4)3.7H2O), aluminum sulfate(KAl2(SO4)3.18H2O), copper sulfate(CuSO2.5H2O), and vinegar (CH3COOH) were chosen and applied to wood blocks with immersion (classic) and immersion+ultrasonic assisted methods.To determine the stability of paint, the effect of such parameters as the medium pH(5, 7 and 9), temperature(22 and 40 °C), agitating speed(10 and 30 rpm) in leaching test was studied. Result showed that, generally aluminum sulfateand ferrous sulfate performed well desorption were reduced the desorption on all wood species surfaces.

*Thisstudy is supportedby a grant (Project Number:110O141) fromTUBİTAK of Turkey . References

1. AngeliniL.G., Bertoli, A., Rolandelli, S., Pistelli, L. Agronomic Potential of Reseda luteolaL. As New Crop for Natural Dyes in Textiles Production. Industrial Crops and Products, 17, 199-207, 2003.,

2. BechtoldT., Ali, A.M.A., Mussak, R., Natural dyes for textile dyeing: A comparison of methods to assess the quality of Canadian golden rod plant material. Dyes and Pigments. 75, 287-29, (2007).

3. Kamel, M.M., Reda M. El-Shishtawy, B.M. Youssef, H. Mashaly, Ultrasonicassisteddyeing. IV.Dyeing of cationised cotton with lac natural dye, Dyes and Pigments, 73: 279-284, (2007).

http://tureng.com/search/agitating%20speed

112

OR-112 Determination of Vitamin A and E Usingthe High Performance Liquid

ChromatographyinMedicinalPlants SuatEKİNa, MahireBAYRAMOĞLUb, HaticeKIZILTAŞa, FevziÖZGÖKÇEc

aDepartment of Chemistry,Faculty of Science, Yüzüncü Yıl University, TR-65080, Van, Turkey bDivision of Biochemistry, Faculty of Veterinary,Siirt University, TR-56100, Siirt, Turkey cDepartment of Biology, Faculty of Science, Yüzüncü Yıl University, TR-65080, Van, Turkey

Natural foods and food derived antioxidants, such as vitamins and phenolic phytochemicals have received growing attention because they are known to function as chemopreventive agents against oxidative damage.Vitamin A (retinol) and vitamin E (α-tocopherol) are lipid-soluble vitamins that are essential for human health. Both groups have free-radical scavenging properties, whichallowthemtofunction as physiologicantioxidants in protectingseveralchronicdiseases, such as cancerandcardiovascular disease. In this study, Salvia limbata C.A.Meyerand Teucriumpolium L.wase valuated for Vitamin A (all-trans-retinol) and vitamin E (α-tocopherol) levels, This is the first work on vitamin in Salvia limbataC.A.MeyerandTeucriumpolium L. In the study, vitamin analysis

was carried out using HPLC method.Vitamin analys was performed with a 5 μm GlScience C18 reverse phase column (250×4.6 mm

ID).The chromatographic system consisted of ThermoScientific Finnigan Surveyor with a photodiode Array detector(PDA) and a trayautosampler (-8ºC). The data were processed with ThermoScientificChromQuest version 4.2 software. The mobile phase of a

methanol-THF mixture (80:20, v/v), at a flow rate of 1.5 mL/min was established. The chromatogram was monitored with PDA

array detection at 325 and 290 nm (-tocopherolandall-trans-retinol, respectively).The results of the study indicated that two medicinal plants have significantly higher content of vitamins A and E were determined. Teucriumpolium L.α- tocopherol levels compared with Salvia limbata C.A.Meyerwerefoundhigher. When the vitamin levels in the plants were

compared, retinol content in theSalvia limbata C.A .Meyer was higher than in theTeucriumpolium L.Theresultscould be used as a reference value is considered to be further studies and medicinal plants as an antioxidant in future studies of

experimental animal models, against free radicals generated in response to oxidative stress.

References

1. S. Kim, M. Yang, O.H. Lee, S.M. Kang, Lwt-FoodScienceandTechnology,2011,44, 1328–1332.

2. Saleh IA, Billedo G, El-Doush I.Journal of FoodCompositionand Analysis,2006,19:167–175.

113

OR-113 An Experimental Study on the Effect of Sonication Time on Viscosity and Fire Resistance

Performance of Nanoclay-based Intumescent Coating Havva Tutar Kahraman1, Erol Pehlivan1, Dilhan M. Kalyon2

1Department of Chemical Engineering, Selcuk University, 42079 Konya, Turkey

2Chemical Engineering and Material Science, Stevens Institute of Technology, 07030 Hoboken, NJ, USA E-mail address: [email protected]

Abstract: It is common to reinforce polymers with a second organic or inorganic components in nano-scale to produce a polymer nanocomposite or nanocoating[1]. Depending on the nature of components (e.g; clay and polymer), the method of preparation (melt, solution or in-situ polymerization) and the processing techniques used, various clay-polymer morphologies viz. phase separated, intercalated or exfoliated structure can be obtained. It is generally believed that dispersion of particles with nanometer sizes within the matrix provides improved mechanical, thermal and barrier properties and fire retardancy[2]. This improvement in properties of generated nanocomposites is direct related to the complete exfoliation of nanoinclusions in polymer matrix. Therefore, processing method and its parameters should be selected very carefully for this purpose. This study is concerned with the efficiency of different intumescent coating formulations designed upon different sonication times to protect steel in the case of fire source. The coatings are based on thermoset epoxy-amin resin system into which fire retardant additives, inorganic particles and organo-modified montmorillonite nanoclay have been incorporated. The first part of the study attempts to prepare epoxy-clay suspensions to investigate precisely the effect of sonication time on fire retardant and viscosity properties of formulations. The second part of the study includes, incorporation of fire retardant additives and other inclusions to these suspensions and evaluation of fire resistance performance and rheological properties using small scale lab tests of these intumescent coating formulations.The experiments show that different sonication time leads to variability of the nanoclay dispersion in epoxy resin, so that fire resistance performance and rheological properties of intumescent coatings formulations are affected with this parameter.

References

[1] S.C. Zunjarro, R. Sriraman, R.P. Singh; J Mater Sci , 2006,41,2219–2228. [2] M. Jimenez, S. Duquesne, S. Bourbigot, Surface & Coatings Technology,2006, 201,979–987.


114

OR-114 Alteration in the nutritional components of Trigonella foenum graecum Linn. Seeds

during Various Germination Phases

Iffat Zareen AHMAD

Department of Bioengineering, Integral University, Dasauli, Kursi Road, Lucknow-226026, Uttar Pradesh, India [email protected]

Abstract: Trigonella foenum graecum Linn. is native to sub-Himalayan plains of Indian subcontinent and now it is widely grown all-over southern and Mediterranean Europe, Middle-East Asia and northern African regions. Traditionally, fenugreek seeds are being used in a wide range of culinary recipes as spice. Fenugreek seeds are rich source of trigonelline, lysine and l-tryptophan and they also contain a large about of steroidal saponins and fibers. It is known to posess antidiabetic activity, antiplasmodic activity, hypolipidemic activity, immunological activity, antibacterial activity, anthelmintic activity, anti-cancer, anti-inflammatory, anti-analgesic activity and antioxidant activity.

During germination the hydrolysis of complicated reserves, including lipids, proteins and carbohydrates takes place to form simple products such as sugars and amino acids which could be used for synthesizing cellular constituents required for growth and differentiation of the embryo. This study was undertaken to investigate the alteration in the nutritional components of Trigenella foenum graecumseed in different phases of germination which could possibly be used for their potential applications against various lifestyle disorders.The seeds were procured in December 2014 from the local grocery store in Lucknow, India. Seed lots used for the different experiments showed germination capacities ranging from 80–98%. Biochemical estimation of various sugars, protein, fats and phytosterols were undertaken in seeds and seedlings of 6 days. Seeds served as control. This study reveals that nutritional components of the seed enhanced during germination. The germinated seeds of Trigonella foenum graecum with varied contents of carbohydrates, fats and proteins may provide additional benefits to the patients suffering from several diet-related diseases since the diet significantly modulate the status and severity of various diseases. Nevertheless, these observations require further investigation. The data of primary metabolites showed very interesting results. There was a gradual increase in the amount of glucose, fructose, sucrose, starch, protein and phytosterol content till 2d with a slight reduction in glucose, fructose, and protein content on 3d. In case of total fats a significant decrease was observed till 4d followed by an increase.

References

1. K. Srinivasan. Food Rev Int. 2006, 22, 203-224. 2. L. Ali, A.K. Azad Khan, Z. Hassan, M. Mosihuzzaman, N. Nahar, T. Nasreen, M. Nur-e-Alam, B. Rokeya, Planta Med. 1995, 61, 358-60. 3. S. Chatterjee, M. Kumar, A. Kumar. Toxicol Int.2012, 19, 287–294. 4. G. Sindhu, M. Ratheesh, G.L. Shyni, B. Nambisan, A. Helen. Int Immunopharmacol. 2012, 12, 205-211.

115

OR-115 CoxPty Nanoclusters Supported on Magnesia Surface; Preparation, Characterization and

the Investigation of the Catalytic Performance in the Dehydrogenation of Aqueous Hydrazine Borane*

Şerif SAĞLAM, Gökhan YEĞİNER, Mehmet GÜLCAN, Mehmet ZAHMAKIRAN

aDepartment of Chemistry,Faculty of Science, Yüzüncü Yıl University, TR-65080, Tuşba, Van, Turkey [email protected]

Abstract: Hydrogen should play an important role in the energy field of the near-future. Accordingly, research has escalated andmuch effort has been dedicated to its production, storage andend-use. However, a number of issues hinder its development. Storage is particularly problematic, mainly because H2 is alight and energetic gas. Safe and efficient storage technologieshave been searched for, and among the various physical andchemical solutions, boron-containing materials haveshown to be promising for chemical hydrogen storage, especially for liquid-state storage.[1]Hydrazine borane (HB, N2H4BH3), containing as high as 15.4 wt% hydrogen calculated from the molecular formula,evidently can be considered as a highly promising chemicalhydrogen storage material. [2]To date, the thermal crackingmethod for HB has been put forward for dehydrogenation, while it needs high energy consumption, and the hydrogen cannot be released completely.[3] In this study, we used the Co-Pt catalyticsystem to catalyze both the hydrolysis of the –BH3 group(1)and the decomposition of the –N2H4 group, while the hydrogen selectivity only reaches ~93 % at 30 ºC and basic medium. The decomposition of N2H4 proceeds via two competitive reaction routes (2) and (3), and the reaction pathways depend on the catalyst used. Therefore, it is of crucialimportance to develop a highly selective catalyst over whichthe dehydrogenation reaction of HB proceeds via pathways (1)and (2), to selectively generate H2.

*This study is supported by a grant (Project Number: 2015-FEN-B267) from Scientific Research Projects Committeeof Yüzüncü Yıl University.

References

1. W. Ben Aziza, J.F. Petit, U.B. Demirci, Q. Xu, P. Miele, Int. J. Hydr. Energ., 2014, 39, 16919-26. 2. D.C. Zhong, K. Aranishi, A.K. Singh, U.B. Demirci, Q. Xu, Chem. Commun., 2012, 48, 11945–11947. 3. T. Hügle, M.F. Kühnel, D. Lentz, J. Am. Chem. Soc., 2009, 131, 7444.


116

OR-116 Expedient and Efficient Synthesis of Trifluoroethyl Ethers from Metal Free Reagent

2,4,6-tris-(2,2,2-Trifluoro-Ethoxy)-[1,3,5] Triazene

Shrawan Kumar Mangawa, Satish K. Awasthi* Chemical Biology Laboratory, Department Of Chemistry, University of Delhi, Delhi India

[email protected] Abstract: Fluorinated ethers (FEs) are one of the most important classes of organic compounds.It is well known that trifluoroethoxy (CF3CH2O-) group increase metabolic stability and lipophilicity. Some blockbuster drugs viz., Lansoprazole (used as antibacterial), Silodosin (treatment of benign prostatic hyperplasia) and Flecainide (introduced into the treatment of arrhythmias in the pediatric population) bearing a trifluoroethyl aryl ether pharmacophore are commercially available. Generally, fluorinated ethers are prepared by nucleophilic addition of alcohols and fluorinated substrates using strong base.Another choice for synthesizing fluorinated ethers is direct fluorination of chlorinated ethers with fluorine gas, Cobalt trifluoride or by electrochemical methods. Williamson etherification is the most simple and convenient method for preparing fluoroethers using alcohols and alkyl halides.However, these fluorinated alkyl halides are responsible for ozone layer depletion. However, there is still need for mild and efficient reaction conditions. In this context, we now report a general process for the synthesisof an acid catalyzed fluorinated alkylating reagent and its use in the synthesis of alkyl/aryl TFE ethers.Chang et al in 1961 introduced the reactions of cyanuric chloride with several negatively substituted primary alcohols in which the electronegative substituents were fluoro, bromo, nitro, or nitroxy groups. Here we report the synthesis of TriTFET with slight modification in previously reported methods using the trifluoroethanol and NaOH as base.The scope of the use of TriTFET for fluorinated alkylation was investigated with various substrates.

References 1. A. J. Matuszko; M. S. Chang. J. Org. Chem. 1962, 77, 677. 2. (a) A. Studer, S. Hadida, R. Ferritto, S.-Y. Kim, P. Jeger, P. Wipf, D. P. Curran. Science, 1997, 275, 823-826. (b) D. P. Curran, T. Furukawa, Org. Lett.

2002, 4, 2233-2235. (c) D. P. Curran, C. Ogoe, QSAR Comb. Sci. 2006, 25, 732-735. (d) N. R. Patel, J. Chen, Y. F. Zhang, R. L. Kirchmeier, J. M. Shreeve. Inorg. Chem. 1994, 33, 5463-5470.

3. S. K. Mangawa, S. K. Bagh, K. Sharma, S. K. Awasthi. Tetrahedron Lett. 2015, 56, 1960-1963. 4. S. K. Mangawa, C. Sharma, A. K. Singh, S. K. Awasthi. RSC Advances, 2015, 5, 35042-35045.


http://en.wikipedia.org/wiki/Benign_prostatic_hyperplasia

http://en.wikipedia.org/wiki/Benign_prostatic_hyperplasia

http://en.wikipedia.org/wiki/Pediatric

117

OR-117 Cobalt Boron Nitride: a Novel Heterogeneous Catalyst for the Synthesis of

Medicinally Important α-amino Quinolinephosphonates

Mahalingam Sureshkumar*, Krishnan Anand, ThangarajMuthu and Robert MoonsamyGengan Department of Chemistry, Durban University of Technology, PO Box 1334,

Durban, South Africa. *Corresponding author: E-mail address: [email protected]

Abstract: A novel cobalt supported on boron nitride (CoBNT) heterogeneous catalyst for the

synthesis of α-amino quinolinephosphonates (AQPs) will be reported. The CoBNT was

synthesised by simply mixing boron nitride in a solution of cobalt acetate, under inert

atmosphere for 7 days followed by filtration. It was used for the synthesis of 17 novel AQPs in

a one pot mixture containing 2-methoxy-3-formyl quinoline, aniline derivatives and diethyl

phosphite. Reactions were rapid, products were easily worked-up and were obtained in more

than 90 % yield. The CoBNT also exhibited higher catalytic activity than conventional catalysts

and was re-used five times without significant decrease in catalytic activity.

The spectroscopic analysis of the novel compounds and catalyst as well as a proposed

mechanism will be presented. A comprehensive discussion of traditional catalysts and the novel

one we prepared in our laboratory will be included.

Keywords: 2-methoxy 3-formyl quinoline, diethyl phosphite, boron nitride, cobalt,

heterogeneous catalyst.


118

OR-118 Hydrothermal Synthesized Nanocrystalline V2O5 and Electrical Properties

Hasan Gocmeza, Mustafa Tuncera, Seher Cetina, Faruk Ebeoglugila

aDepartment of Material Science and Engineering,Faculty of Engineering, Dumlupınar University, Kutahya,

Turkey

Abstract: Vanadium oxide nanopowders were synthesized by hydrothermal process. The phase structure and morphology of nanocrystalline vanadium oxide powders were carried out with X-ray diffraction (XRD) and Scanning Electron Microscopy (SEM). XRD results showed that well-crystallized V2O5 structure with crystalline size about 80 nm. The SEM results showed that when the temperature was increased from 170 to 180 oC, different morphology of powders can be obtained. The electrical properties of V2O5 ceramics were also determined. This study is supported by a grant (Project Number: 2014-12) from Scientific Research Projects Committee of Dumlupinar University.

119

OR-119 Optimization of Production of Sodium Pentaborate from Ulexite Ore and Sulfur Dioxide

Mehmet Muhtar KOCAKERIMa, Vedat Arda KÜÇÜKa,

aDepartment of Chemical Engineering,Faculty of Engineering, Çankırı Karatekin University, TR-18100, Çankırı, Turkey Abstract: Sodium pentaborate received attention due to its high boron trioxide content per molecule and superior aqueus solubility according to the other borate salts. Sodium pentaborate has extensively been used in many branches of indusrty as well as in agriculture. Sulfur dioxide is readily available both as a commercial product and side product in many branches of industry in great amounts. The aim of this study is to determine optimum reaction parameters of ulexite and sulfur dioxide in aqueus medium. Liquid product of the reaction will be dried with spray dryer and batch dryer in order to obtain sodium pentabrate in crystalline form. Reaction temperature, pH, solid/liquid ratio, paticle size of ulexite ore chosen as parametres after pilot experiments. Taguchi orthogonal L16 array used in experimental design in order to reduce trials and determine optimal reaction conditions. It is observed that sulfur dioxide is highly effective in leaching ulexite. It is found that average leaching rate of the ulexite regarding to the boron trioxide amount is over %99 while the minumum leaching rate is over %97.

References

1. E. Kavcı, T. Çalban, S. Çolak, S. Kuşlu, J. Ind. And Eng. Chem., 2014, 20, 2625-2631. 2. Ö. Küçük, M. M. Kocakerim, Chem. Eng. and Processing,2005, 44, 1005–1011 3. A. Künkül, S. Yapici, M. M. Kocakerim, M. Çopur, Hydrometallurgy, 1997, 44(1), 135-145 4. M. Alkan, M. Oktay, M. M. Kocakerim, Z. Karagöz, Hydrometallurgy, 1991, 26(2), 255-262

120

OR-120 Propericiazine as a Selective and Sensitive Reagent for The Spectrophotometric

Determination of Microgram Amounts of Platinum in Minerals.

A.Thimme Gowda

Haranahalli Ramaswamy Institute of Higher Education Behind Akshavani, Salagame Road, Hassan-573201, Karnataka, India.

E-mail:[email protected]

Abstract:

Propericiazine(PPC) is proposed as a new sensitive and selective reagent for the spectrophotometric

determination of microgram amounts of platinum. PPC forms a pink complex with platinum(IV) at room

temperature (26+20 C) in hydrochloric acid - sodium acetate buffer medium containing copper (II) ions. The

complexation is complete within 10 min. The complex exhibits an absorption maximum at 520 nm with a molar

absorptivity of 1.204 X104 liters mol-1cm-1. Beer’s law is obeyed over the concentration range 0.5-12.2 ppm of

platinum. A 50-fold molar excess of the chromogenic regent is necessary for the development of maximum

colour Intensity. Job’s method of continuous variation, the molar ratio method, and the slope- ratio method

indicate a 1:1 composition for the complex. The effects of pH, time, temperature, reagent concentration, order

of addition of reagents and interference for various ions are reported. The reagent has been used successfully

for the determination of platinum in minerals and alloys.

Procedure: To an aliquot of the sample solution containing 12.5 – 305 µg of platinum (IV) were added

5 ml of hydrochloric acid- sodium acetate buffer of pH 2.1, 1ml of 0.1M Cu(II) sulphate solution, and 3.0 ml of

0.5% propericiazine solution. The solution was diluted to 25 ml with distilled water, mixed thoroughly, and the

absorbance measured at 520 nm against a reagent blank solution after 10 min. The platinum concentration of

the sample solution was determined using a standard calibration curve.

----------------ooo--------------------


121

OR-121 Synthesis of Dihydropyrimidine Compounds by Biginelli Reaction and Performing the

Eschenmoser Coupling Reaction * Esvet AKBASa and Erdem ERGANa

aDepartment of Chemistry, Faculty of Science, Yuzuncu Yil University, TR-65100-Van, Turkey E-mail: [email protected]

Abstract: Pyrimidine derivatives are attractinggreat interest by many research groups due to their multiple biological and medical properties such as cardiotropic, antineoplastic, antihypertensive, antiviral, antibacterial and anticancer agents[1].

Various synthesis methods have been reported up to date in the literature for pyrimidine derivatives and majority of them is based on the Biginelli three component cyclocondensation reactions [2,3]. It is very simple one-pot, acid catalyzed cyclocondensation reaction of benzaldehyde, urea and ethyl acetoacetate carried out in ethanol in the presence of a few drops of concentrated hydrochloric acid.

In this study, we report the synthesis of substituted dihydropyrimidines, via the three componentcyclocondensation reaction and investigation of next reaction stepsand performing Eschenmoser coupling reaction

NH

NHAr

O

Ar S

+NH

NHAr

O

Ar S

H

Br

H

OCH2CH3

HH

O NH

NHAr

O

Ar S

OCH2CH3

HOH

NH

NHAr

O

Ar S

OCH2CH3

HOH

Episulfide ring system

NH

NHAr

O

Ar

-HS

OCH2CH3O

N+

N

Br

-

OCH2CH3

O

X

XX

X

X

*This study is supported by a grant (Project Number 2014 FBED113-2012-YNL-MRK003) from Scientific Research Projects Committee of Yuzuncu Yil University.

References

1. R.A. Janis, P.J. Silver, D.J.Triggle, Adv. Drug Res.,1987, 16, 309-591.

2. C.O. Kappe, P. Roschger, J. Heterocyclic Chem.,1989, 26, 55.

3. F. Aslanoğlu, E. Akbaş, Phosphorus, Sulfur, and Silicon and the Related Elements.,2007, 182, 1589-1597.


122

OR-122 Selective Separation of Alkyl Tert-alkyl Ethers from Alcohol and Hydrocarbons

Containing Azeotropic Mixture by Ionic Liquids Akif AZIZOV,Hamide AZIZBEYLI, Reyhan ALIEVA

The Institute of Petrochemical Processes named after Y.H.Mammadaliev of Azerbaijan National Academy of Sciences, Khojali district 30, Baku, Azerbaijan

Abstract:

It is known that upon etherification of olefins and olefin-containing fractions (particularly, C3-C7 fractions) with various C1-C5 monoatomic alcohols in the presence of catalysts the main products of the reaction are alkyl-tert-alkyl ethers which are the components of high-octane, oxygenate fuels, as well as unreacted hydrocarbons and mixture of alcohols. Since these products form tile azeotropic mixtures, the separation of them in a pure form by simple distillation is not possible. The assigned task is the development of available methods for effective separation of azeotropic mixture consisting of alkyl-tert-alkyl ethers, alcohol and hydrocarbons, as well as the development of extragents possessing high selectivity.

Selective treatment method of alkyl tert-alkyl ethers with ionic liquids consists of three steps: 1) Selective extraction of azeotropic mixtures obtained from etherification reaction; 2) Separating ethers from mixture; 3) Returning selective solvent back to the process.

The di-, trietanolammonium pentonate ionic liquids were used as selective solvents. The IL : azeotrope mixture was choosen in 0,510:1 ratios. Extraction process was carried out at 40-60 °C with continuously stirring ionic liquid and azeotropic mixture within 30-40 minutes. Alkyl tert-alkyl ether removed from mixture by phase separation with yield 92-97 % by weight. This index is calculated on the basis of data of chromatographic analysis of purified products. The ionic liquid recovered from extract by rectification and recycled back to the extraction process [1].

The use of ethanolamine as amine component provides the similarity in the compositions of liquid salts and alcohol hydroxyl groups and leads to selective adsorption of an alcohol by ionic liquid salts during extraction process. Alkyl-tert-alkyl ethers not being mixed with ionic liquid salts are separated in a pure form. Extracted alcohol is easily separated from ionic liquid by rectification. So, ionic liquids not undergone to any changes as complex salts and don’t loses their extractive ability.

For predicting useful ionic liquids 40 cation and 35 anion were screened theoretically with COSMO-RS method. It was found that there are good agreements between experimental and theoretical screening results. References 1.(Patent) Azizov A.Q., Alieva R.V., Bagirova Sh.R., Kalbalieva E.S., Amanullaeva G.I., Azizbeyli H.R., Mamadli R.Z. Selective treatment method of alkyl-tert-alkyl ethers with ionic liquids Euroasian patent №017313, 2012

123

OR-123 Purification of Bioactive Fractionations of Industrial Importance from Citrus reticulata

Blanco Waste Peel

Muhammad Asif Hanifand Rabia Idrees

Department of Chemistry, University of Agriculture, Faisalabad-38040-Pakistan

( [email protected])

Abstract:

In the present study, essential oil from Citrus reticulata Blancowaste peel is exploited for its commercially important components like limonene, geraniol and citral as well as the methodology for the production of its bioactive fractions has been comprehensively described. Extraction of oil was carried out at different temperatures (110-120°C) followed by fractionational distillation and low temperature chilling. Maximum essential oil yield was obtained at 115°C. Gas chromatographic mass spectrometric (GC-MS) analysis showed that limonene, geraniol and citral were present in major concentration in citrus peel oil. Limonene, geraniol and citral have important role as flavoring and fragrance components. These were separated from all other minor components present in the citrus peel oil to determine their collective antioxidant and antifungal activities. Antioxidant activity of Citrus reticulata Blancopeel oil and its fractions separated by fractional distillation and chilling werealso determined. Antioxidant assays were carried out to determine total phenolics, flavonoids, flavonols, hydrogen peroxide and DPPH scavenging activities. Disc diffusion method was used to determine antimicrobial activities of essential oil against Penicillium notatum and Aspergilus niger.

References

1. Agbaji, A., Dakare, M., Akin-Osanaiye, B;Journal of Plant Sciences.2008,3, 199-202. 2. Ahmad, M.M., Iqbal, Z., Anjum, F., Sultan, J;Pakistan Journal of Botany.2006,38, 319. 3. Bejar, A.K., Mihoubi, N.B., Kechaou., N., Food Chemistry, 2012. 132.

mailto:%[email protected]

124

OR-124 (Oligo)Alkylation of Toluene with Alpha-Olefins in The Presence of Ionic Liquids

Khayala SEIDOVA1,AkifAZIZOV1, ReyhanALIYEVA1, Igrar NAZAROV2, Aygun ABDULLAYEVA2 1The Institute of Petrochemical Processes named after acad. Y.H. Mammedaliyev of Azerbaijan

National Academy of Sciences, Azerbaijan, Baku 2Baku branch of Moscow State University after M. V. Lomonosov, Azerbaijan, Baku


In this thesis the resultson alkylation of toluene with alpha-olefins in the presence of chloroaluminate, [bmim]+[BF4]-,

[emim]+[HSO4]- ionicliquidswere presented. The(oligo)alkylation reactions were carried out at 30-1000C temperaturesby intensive

stirring of reaction mixture during 0.3-3 hours.Then the unreacted monomer was distilled off from the obtained oil. It was foundthat

depending on the process conditions the yield of the fraction (b.p.≥ 2000C) is 4-59%.

The molecular structures, weights, viscosity and other physical and chemical characteristics of synthesized oligoalkylates

were analyzed by exclusion chromatography, DSC-, IR-, UV- and PMR- spectroscopy methods. It was foundthatdepending on the

catalyst composition it is possible to obtain various substitutions ofoligoalkylate products.

The synthesized oligoalkylate products were characterized by low density values (0.8433-0.8410), high

viscosity index (88-105), low freezing point (-700C), high ignition temperature, good antioxidative stability

(≥1500C), detergency and low volatility.

Thus, studies have shown that the aforementioned ionic liquids suitable for the oligomerization [1] and

oligoalkylation [2] of alpha-olefins.

References

1. A. H.Azizov, R.V.Aliyeva, Kh.H. Seidova,Green and Sustainable Chemistry, 3, 2013, 18-26

2.A. H.Azizov, R. V. Aliyeva, Kh.H.Seidova, E.M.Karayeva, I. G.Nazarov, A.M.Abdullayeva, American

Journal of Chemistry and Application 2015, 2(3), 2015, 21-26

125

OR-125 Polyvinyl Pyrrolidone Coated Iron Oxide Nanoparticles as Contrast Agents for Magnetic

Resonance Imaging (MRI) Muhammad Irfan MAJEEDa

aDepartment of Chemistry,Faculty of Sciences, University of Agriculture Faisalabad, 38040,Faisalabad, Pakistan Abstract: Iron oxide (Fe3O4) nanoparticles due to their advantages such as high saturation magnetization, superparamagnetic nature and biocompatibility are applied as contrast agents for magnetic resonance imaging (MRI). Co-precipitation method yields magnetic iron oxide nanoparticles (MIONs), which are directly dispersed in aqueous phase and are feasible for bio-applications. Water-soluble polymers are excellent capping ligands for the preparation of MIONs in aqueous phase. The functional groups present on the polymer chains are linked to the MIONs surface through electrostatic or covalent interactions and effectively arrest their growth as well as provide them excellent water solubility, chemical stability and multifunctional rich surface chemistry. Herein we describe the preparation of MIONs, through co-precipitation method using trithiol terminated multifunctional polymer (PTMP-PVP) as capping ligand. MIONs obtained with 2.0 mM polymer ligand concentration had core size and hydrodynamic diameter of 6.0 ± 0.7 nm and 20 nm respectively analyzed by TEM and DLS. The presence of polymer ligand on the MIONs was confirmed through FTIR. XRD analysis revealed the crystalline structure and phase of iron oxide as magnetite (Fe3O4). Magnetic properties of the MIONs, measured by vibrating sample magnetometer (VSM) at 300K, showed their superparamagnetic behaviour with a saturation magnetization of 70 emug-1. MIONs were found to be highly biocompatible as determined by MTT-assay performed on rat macrophages. In vitro test revealed their strong and obvious transverse relaxivities, which made them potential candidates as negative contrast agents for MRI.

Scheme1.Preparation of magnetic iron oxide nanoparticles with PTMP-PVP.

References

M. I. Majeed, Q. Lu, W. Yan, Z. Li, I. Hussain, M. N. Tahir, W. Tremel, B. Tan, J. Mater. Chem. B, 2013, 1, 2874-2884.

126

OR-126 Complex Catalytic Systems on Based of Zirconium Phenolates Containing Amino

Hydrochloride Substituents for Oligomerization of the Ethylene A.A.Khanmetova, M.J.Khamiyeva, A.H.Azizova

aInstitute of petrochemical processes, Azerbaijan National Academy of Sciences, 30, Khojaly Ave., AZ1025, Baku, Azerbaijan

[email protected] The α - olefins are widely used in obtaining surface - active substances, synthetic oils have a lower freezing temperature, demulsifiers, corrosion inhibitors, plastifiers and others. Butene-1, hexen-1, and okten-1 has a special importance in the industry so they are used as monomers to obtain polyethylene with low density.

In this paper has been devoted to interpretation the result oligomerization of ethylene in the presence of new complex catalytic systems on the basis of zirconium phenolates containing amine hydrochloride substituents. Linear olefins having high selectivity to obtain by oligomerization of ethylene in the presence of catalytic systems on based of transition metals (Ni, Ti, Zr, etc.). Phenolates of zirconium which containing amine hydrochlorides substituents have synthesized in the following scheme.

n= 2,3, R = diethylamine, piperidinyl, morpholine, 2-[(2,6-diisopropylphenyl)-imino] phenol Burada n = 2,3, R = N(C2H5), piperidinil, morfolil,2-[(2,6-di(izopropil)fenil)-imino]fenol. Synthesized zirconium phenolates does not dissolve in the aromatic and aliphatic solvents, but dissolve in DMSO and ionic liquids. The synthesized compounds have been analyzed by IR, NMR spectroscopy, DSC, SEM, and element analysisIt was determined that, the synthesized compounds to create active catalytic systems from interacting with alkylaluminum chlorides ((C2H5)nAlCl3-n) at molar ratio Al : Zr = 15 ÷ 50in aromatic and aliphatic solvents for ethylene oligomerization process. The obtained active complexes use as heterogeneous complex catalysts in the oligomerization process of ethylene.The synthesized compounds of zirconium phenolates, the type of alkyl aluminium compound, the ratio of catalyst compounds, the nature of solvent and the influence of others factors to the product oligomerization of ethylene and activity of catalytic systems have been investigated.It was determined that, the product oligomerization of the ethylene in the presence of (C2H5)2AlCl mainly consists of olefins and in this case the yield fraction of C4 – C8is 90 - 95 % to converted ethylene.


127

OR-127 Controlled Radical Polymerization of Some Acrilyc Monomers

Guliyeva I.M.

Yu.G. Mammadaliev Institute of Petrochemical Processes of Azerbaijan National Academy of Sciences

There has been synthesized cyclohexyl- and cyan(methyl)norbornyl(meth)acrylate monomers and their

controlled radical polymerization werecarried out in the presence of controlled system - Cu containing metal-polymer nanocomposite (MPNC) and benzoyl peroxide, tricyclo(5.2.1.02,6)des-3-en-8(9)il -chloracetate as inisiator.

Synthesized products have been identified on the basis of modern physico-chemical analysis methods and offered controlled radical polymerization mechanism is as following.

The synthesized oligomer products was pure and solid. They are soluable in the CCl4, acetone and

dimethylformamid solvents.

The investigation of obtained results shows that, it is possible to receive the acrylate macromonomers with

enough high yields (›50%) by the regulated polymerization of synthesized acrylate monomers.

128

OR-128 Synthesis, Antimicrobial Activity of New 2- Thioxanthine and dipyrimidopyridine

derivatives

Samar El-kalyoubi1, Fatmah Agili2 and Shaker Youssif 3,4 1Organic Chemistry department, Faculty of Pharmacy, ElAzhar University (Girls), Egypt.

2Chemistry department, Faculty of Science, Jazan University, Jazan, (Female Section), Saudi Arabia. 3Medical Chemistry division, faculty of Medicine, Jazan University, Jazan, Saudi Arabia.4Chemistry department, Faculty of Science, Zagazig University, Zagazig,

Egypt. Abstract: Several fused imidazolopyrimidines were synthesized starting from 6-amino-1-methyl-2-thiouracil (1) followed by nitrosation, reduction, condensation with different aromatic aldehydes. The dehydrocyclization of Schiff’s

base using iodine/DMF gave compounds 5a-g. The alkylation of 5a-g using a simple alkylating agent as dimethyl sulfate [(CH3)2SO4] at room temperature gave monoalkylated 6a-gwhile,on heating gave dialkylated imidazolopyrimidines 7a-g. On the other hand, the treatment of 1 with different aromatic aldehydes in acetic acid under reflux or in abs. ethanol/HCl at room temperature afforded bis 5,5-diuracylmethylene 8a-f which cyclized on heating with a mixture of acetic acid/HCl (1:1) to give 9a-f.Compound9a-fcan obtain directly by refluxing of compound 1with a mixture of acetic acid/HCl. The synthesized new compounds were screened for antimicrobial and MIC was measured.

N

N

O

N

N

CH3H

Ar

H3CS N

NH

O

S

N

N

CH3 H

Ar

N

NH

O

S

CH3

NH2

N

NH

O

S

CH3

NH2

NH2

N

NH

O

S

CH3

NH2

N = CH - Ar

1 3 4a - g

5a - g6a - g

N

NH

O

S

CH3

NH2

NO

N

N

O

N

N

CH3CH3

Ar

H3CS

7a - g

2

i ii iii

iv

vvi

Sheme 1

N

NH

O

S

CH3

NH2

AcOH/ reflux or

N

NH

O

S

CH3

NH2

NH

NNH2

O

S

CH3

Ar

+

CHO

R

Abs EtOH/ HCl/ r.t.

HCl/ AcOH/ reflux

N

NH

O

S

CH3

NH

NH

N

O

S

CH3

Ar

HCl/ AcO

H/ refl

ux8a-e

9a-e

1

Scheme 2

129

OR-129 Chemical Synthesis of 3,6-Bis-(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-9-(4-vinylbenzyl)-

9H-Carbazole and Polymer Formation Used as Supercapacitor Electrode Material* Nesimi ULUDAGa, and Murat ATESa

aDepartment of Chemistry, Faculty of Art and Science, Namik Kemal University, TR-59030, Tekirdag, Turkey Abstract: In this study, 3,6-bis-(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-9-(4-vinylbenzyl)-9H-carbazole monomer was chemically synthesized and electrochemically synthesized as supercapacitor electrode material [1, 2]. This new polymer was characterized by cyclic voltammetry (CV), Fourier transform infrared spectroscopy (FTIR)-Attenuated total reflectance (ATR), scanning electron microscopy (SEM)-energy dispersive X-ray analysis (EDX), atomic force microscopy (AFM) and electrochemical impedance spectroscopy (EIS) analysis. Polymer matrix was enhanced with carbon nanotube (CNT) as a composite material. The highest specific capacitances were obtained as Csp= 132.6 F×g-1 and 90.53 F×g-1 at a scan rate of 70 mV×s-1 with area and charge formula by CV method, respectively.

Scheme1. The synthesis procedure of 3,6-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-9-(4-vinylbenzyl)-9H-carbazole. *This study is supported by a grant (Project Number: 110T791) from The Scientific and Technological Research Council of Turkey.

References

1. M. Ates, N. Uludag, F. Arican, High Perfromance Polymers, 2014, 26(5), 587-597. 2. M. Ates, N. Uludag, T. Karazehir, F. Arican, J. Solid State Electrochem., 2013, 17(9), 2417-2427.

130

OR-130 Chemical Aspects of the Design Topological Insulators Based

on the Metal Chalcogenides

1BabanlyM.B., 2ChulkovE.V., 1,2,3Aliev Z.S., 3Amiraslanov I.R. 1Institute of Catalysis and Inorganic Chemistry,

Azerbaijan National Academy of Sciences, Baku, Azerbaijan 2Donostia International Physics Center, Donostia-San Sebastian, Spain

3Institute of Physics, Azerbaijan National Academy of Sciences, Baku, Azerbaijan [email protected]

Topological insulators (TIs) constitute a novel class of materials that has received a large amount of

attention over recent years [1]. TIs represent a new phase of quantum matter with innovative electronic properties [1]. These materials are semiconductors in the bulk, but they have surface states which imply metallic conduction at the surface. The nature of these surface states is directly related to the non-trivial topology of the bulk bands, consequence of the inversion symmetry between the first conduction band and the last valence band produced by the effect of a strong spin-orbit coupling. These exotic properties open the opportunity to realize a number of new applications inspintronics and quantum computing.

Nowadays binary tetradymite-like layered bismuth and antimonychalcogenides[2-4]and homologous series of ternary compounds in the pseudo-binary systems AIVX− mBV

2X3(AIV= Ge, Sn, Pb; BV=Bi,Sb; X=Se, Te) and TlBVX2 [4-8] compounds are attracting renewed interest because they exhibit time reversal symmetry and non-trivial topological order and, consequently, they are promising materials for applications in spintronics and plasmonics. These materials are also known excellent thermoelectric materials which are suitable for cooling, thermoelectric solar cells, waste heat recovery units, and power generation.

In order to investigation their Tls properties it is necessary high-quality single crystals, however, with respect to some experimental difficulties only several member of the mentioned above homologous series were grown as bulk ingot.

Bibliography data on the phase diagram of the BV-Te and AIVX-BV2X3 systems shows that due to structural

features of the tetradymite-like phases the plotted phase diagrams of these systems using traditional methods (melting+thermal homogenization) displays metastable state.

In the present work, the chemical aspects of the design, synthesis and growth single crystals of mentioned above binary and ternary phases are reported. In order to plot equilibrium phase diagrams of mentioned system new approaches were suggested.

This paper also discusses the design and structural features of the multicomponent cation- and anoin substituted phases based on the already known binary and ternary tetradymite-like compounds.

*The work was supported by the Science Foundation of the State Oil Company of Azerbaijan Republic (Grant for the project "Preparation and investigation of new functional materials based on complex metal chalcogenides for alternative energy sources and electronic engineering", 2014).

References

1. Moore. The Birth of Topological Insulators; Nature,2010, 464, 7286

2. EremeevS.V., KoroteevY.M., Chulkov E.V.;JETP Letters,2010, 91, 419. 3. Sumalay R., Meyerheim H.L., Ernst A., et al.; Phys. Rev. Lett., 2014, 113, 116802. 4. Eremeev S.V., Landolt G., Menchikova T.E. et al.;Nature Commun.,2012, 3, 635. 5. Okuda T.,Maegawa T., Ye M. et al.;Phys.Rev.Lett., 2013, 111, 205803-5 6. Politano A., Caputo M., Nappini S. et al.;J.Phys.Chem.C, 2014, 118, 21517. 7. EremeevS.V., KoroteevY.M., Chulkov E.V.;JETP Letters, 2010, 91, 664. 8. Pielmeier F., Landolt G., Slomski B. et al.;New J. Phys., 2015, 17, 023067


POSTER PRESENTATIONS

132

PO-1 New and Efficient Synthesis of Brominated Diazanaphthalene Derivatives: Key

Compounds for Strongly Biologicaly Active Derivatives Sefa UÇAR, Arif DAŞTAN, Erdin DALKILIÇ, Selçuk EŞSİZ

Department of Chemistry,Natural and Applied Science, Atatürk University, TR-25240, Erzurum, Turkey Abstract:

Diazanaphthalene derivatives are very important in hetereo, bioorganic and pharmaceutical chemistry.1 For this reason there has

been tremendous interest in new and efficient synthesis of diazanaphthalene derivatives. Halogenated, especially brominated

organic compounds are key for the synthesis of other derivatives.2 There are a few methods in the literature for the synthesis of

bromine derivatives of diazanaphthalene. But the numbers of the known halogenated derivatives are limited and generally known

methods are based on low yielding multi-step reaction scheme. In this project, our goal is synthesis of bromine derivatives of

diazanaphthalenes by different approaches.

Scheme1. Starting materials and obtained products from bromination reactions.

*This study is supported by TUBİTAK (Project Number: 113Z160). We would like to extremely thank to TUBİTAK for their financial support of this work.

References 1. Gautam, N.; Chourasia, O. P., Indian J Chem B 2010,49 (6), 830-835.

2. Dong, Z. B.; Clososki, G. C.; Wunderlich, S. H.; Unsinn, A.; Li, J. S.; Knochel, P., Chem- Eur J 2009,15 (2), 457-468.

N N N N BrnBrm

n,m=0, 1, 2 ... and n+m=1-6

133

PO-2 Effect of Filler Particle Size on Ionizing Electromagnetic Radiation Shielding

Performances of Natural Mineral-Polymer Composites Ezgi Eren Belgin1, Gül Asiye Ayçık1, Ayşe Kalemtaş2

1Mugla Sitki Kocman University, Faculty of Science, Department of Chemistry, Mugla, Turkey, [email protected] 2Bursa Technical University, Faculty of Natural Sciences, Architecture and Engineering, Department of Metallurgical and Materials

Engineering, Bursa, Turkey Abstract:

It is known that composite filler particle size affects radiation attenuation properties of the material beside several mechanical and physical properties [1]. Thus, in the present study, it is attempted to investigate filler particle size effect of previously prepared and characterized isophthalic unsaturated polyester (PES) based and ilmenite (natural titanium-iron oxide mineral) filled composites for ionizing electromagnetic radiation (IEMR) shielding applications. The role of ilmenite was to increase the IEMR shielding performance of the composite while the role of polymer matrix was to provide load-stress transfer and to give easy formability and processability to the composite. The shielding properties of the composites were investigated for three different IEMR energy regions as low, intermediate and high energies since interaction mechanisms of IEMR with matter differs mainly according to IEMR energy.

In this manner, filler particles were crushed to four different particle sizes as and prepared by the same method and characterized gamma spectrometrically. At the end of the study, it was seen that as the filler particle size decreased the IEMR attenuation performance of the prepared composites were increased, Figure 1.

Figure 1. IEMR attenuation performances of the prepared composites with respect to composite filler particle

size

References

Y. Dong, S. Chang, H. Zhang, C. Ren, B. Kang, M. Dai, Y. Dai; Chin. Phys. Lett., 29, 10, 108-102, 2012.

0

5

10

15

20

25

30

35

40

<74 µm <50 µm <37 µm <7 µm

IEM

R a

tte

nu

atio

n r

ate

(%)

IEMR absorber composite with different filler particle size

0-500 keV

500-1000 keV

>1000 keV


134

PO-3 Synthesis and characterization of thermal energy storage properties of

polystyrene/(nonadecane-octacosane) micro-nano capsules*

Ahmet SARI, Alper BİÇER, Cemil ALKAN, Çınar KIZIL

Department of Chemistry, Gaziosmanpaşa University, 60240 Tokat, Turkey [email protected]

Thermal energy storage materials by solid-liquid phase change can be encapsulated in micro-nano sizes using suitable polymeric shell materials. This type encapsulation of phase change materials (PCMs) prevent their leakage problem during phase change process and dissolve the odor problem besides providing them inert properties to the environment and high surface/volume ratio for heat transfer and also directly utility advantage in thermal energy storage systems [1,2]. Therefore, in recent years, the most of the studies about this subject is focused on the development new encapsulated PCMs [3]. In this regard, this study is aimed to characterize the chemical and morphological structure and determine thermal energy storage properties of the micro-nano encapsulated nonadecane (C19)-octacosane (C28) eutectic mixture as PCM by using polystyrene (PS). Firstly, C19-C28 eutectic mixture was prepared to decrease the melting temperature of C28 and thus expand its utility areas for thermal energy storage applications. PS/(C19-C28) micro/nano capsules were synthesized successfully by using emulsion polymerization method. In the capsules, C19-C28 eutectic mixture acts energy storage materials with solid-liquid phase change as PS has shell function. The encapsulation parameters such as monomer(styrene)/(C19-C28) ratio, homogenization rate, temperature, surface active material, cross linking agent were optimized systemically. The PS shell formation around the eutectic PCM was verified by FT-IR spectroscopy analysis. The surface morphology of the synthesized capsules was characterized by SEM and POM techniques and the size distributions of them were PSD analysis. The SEM and POM results showed that the most of the capsules had spherical shape and they are consisted of nano spheres as well as micro spheres. The PSD analysis results indicated that the capsules had almost uniform PSD value in the range of 0.01 -50 µm and the mean diameter of them was 7.5 µm. The DSC anaysis results indicated that the synthesized capsules with highest eutectic mixture ratio (monomer/C19-C28 ratio: 1:2) including had a melting temperature of 30.62oC and a latent heat of 107.44 J/g. The thermal cycling test revealed that the prepared capsules preserved the thermal energy storage properties even after 5000 melting/freezing process. In this study, the sublimit value of degradation temperature of the capsules were measured. All results exposed that the synthesized PS/(C19-C28) micro-nano capsules were promising materials for passive solar thermal energy storage applications with heating and cooling purposes.

*The author would like to acknowledge by Scientific and Technological Research Council of Turkey (TÜBİTAK) for financial support (Project No:112T864). References [1] Y., Boan, Physical Mechanism and Characterization of Smart Thermal Clothing. (PhD Thesis), (2005), The Hong Kong Polytechnic University, Hong Kong, 267p. [2] G.L., Zou, Z.C., Tan, X.Z., Lan, L.X., Sun, T., Zhang, Chinese Chem. Letters, 15(6) (2004) 729-732. [3] Zhao, C.Y. Zhang,G.H. Renew. and Sust. En. Rev. 15 (2011) 3813.


135

PO-4 Preperationand Characterization of Magnetic Featured Horseradish Peroxidase Hybrid

Nanoflowers

Nalan ÖZDEMİRa, İsmail ÖÇSOYb,c, İsmail YILMAZa

aDepartment of Chemistry,Faculty of Science, Erciyes University, TR-38039, Kayseri, Türkiye ([email protected])

bDepartment of Analytical Chemistry, Faculty ofPharmacy, ErciyesUniversity, TR-38039, Kayseri, Türkiye cNanotechnologyResearch Center, ErciyesUniversity,TR-38039, Kayseri, Türkiye

Abstract: As naturalbiocatalysts, enzymes have received considerable attention owing to their unique properties, including high catalytic activity, stability, selectivity, low toxicity and water-solubility. The instability of the free enzymes in aqueous solution strictly limits their applications. Some immobilization techniques have been used to enhance catalytic activity and stability. Immobilization of enzymes generally enhances stability, presumably due to reduced mobility and attachment of more enzymes on per volume unit of support compared to free enzyme dissolved in solution. However, increasing catalytic activity is generally limited due to mass transfer limitations. In this study, magnetic featured Cu2+ions incorporated horseradish peroxidase (HRP) based hybrid nanoflowers (hNFs) were synthesized and a mechanistic elucidation of enhancement in catalytic activity and stability of the synthesized hNFs were studied.The effects of synthesis conditions on the catalytic activity and stability of hNFs were evaluated by oxidation of guaiacoltoa colored compound in the presence of hydrogenperoxide. The activities of hNFs were higher than free HRP in PBS under all conditions. This work was supported by a Grant from the Scientific and Technological Research Council of Turkey (115Z092). References

1. J. Ge, D. Lu, Z. Liu and Z. Liu, Biochem.Eng. J.,2009, 44, 53–59. 2. J. Ge, J. Lei and R.N. Zare, Nature Nano.,2012, 7, 428–432.

136

PO-5 M/SiO2 (M= Co, Fe, Ru) Type Materials: Synthesis and Catalytic Activities for

Hydrogenation of Ketones Nilgun KALAYCIOGLU OZPOZAN, Serkan DAYAN, Sevgi OZTURK

Erciyes University, Science Faculty, Department of Chemistry, 38039, Kayseri Abstract: Compounds containing ruthenium, cobalt or iron are also widely used in the applications of various catalytic reactions (hydrogenation, C-H bond activation, C-N bond formation, C-C bond formation, hydrosilylation, transfer hydrogenation (TH) etc.), in biosensors, solar cells, luminescence, anti-cancer drugs, inhibition etc. The transfer hydrogenation reactions of various organic molecules are necessary, typically using a hydrogen donor together with a strong base and catalyst, and are preferred for large-scale industrial applications, energy and lowering toxicity. Furthermore, the transfer hydrogenation (TH) reaction of ketones is a pivotal reaction for secondary alcohols that has recently attracted much attention (1-3). Herein, M/SiO2 (M= Co, Fe, Ru) type materials were successfully synthesized by solid-supported (SiO2) and metal salts via NaBH4 as a reducing agent (Fig.-1). The structural elucidations of the materials were characterized by different methods such as FT-IR, TG/DTA, and nitrogen adsorption-desorption (BET), SEM and EDX. These materials were applied for the transfer hydrogenation (TH) of ketones in the presence of 2-propanol (as the hydrogen source). The TH experiments showed that all materials are average catalytic precursors (1-3).

MM

M

M

MM

M

M

M

M

M= Co, Fe, Ru

SiO2Metal Salts

NaBH4

SiO2

Figure 1. Synthesis of M/SiO2 (M= Co, Fe, Ru) type materials

Acknowledgements We acknowledge the financial support granted by Erciyes University (ERUBAP)

References

1. C. Janke, M.S. Duyar, M. Hoskins, R. Farrauto, Appl. Catal. B: Environ. 2014, 152–153, 184–191. 2. S. Dayan, N.O. Kalaycioglu, O. Dayan, N. Ozdemir, M. Dincer, O. Buyukgungor, Dalton T, 2013, 42,

4957-4969. 3. R. Noyori, S. Hashiguchi, Accounts Chem. Res. 1997, 30, 97-102.

137

PO-6 Synthesis and Some Reactions of 4-(4-Methylbenzoyl)-3-(4-Methylphenyl)-1-Pyridin-2-

yl-1H-Pyrazole-5-Carboxylic Acid

Elif KORKUSUZ1, İsmail YILDIRIM2

aKayseri Vocational College, Erciyes University, TR-38039 Kayseri [email protected]

2Department of Chemistry, Erciyes University, TR-38039 Kayseri,

Abstract: Pyrazole derivatives are generally well-known nitrogencontaining heterocycles, and various procedures have been developed for their syntheses. The chemistry of pyrazole derivatives have been the subject of much research due to their importance in various applications and their widespread potential biological and pharmacological activities (antiinflammatory, antipyretic, antitumor, pesticidal, antihistaminic, antibiotics, antidepressant, antibacterial etc.) [1,2]. Concerning the attempt to synthesize some novel pyrazole and fused pyrazole derivatives from 4-(4-methylbenzoyl)-5-(4-methylphenyl)-2,3-furandione 1and various hydrazines or hydrazones, the synthesis of 4-(4-methylbenzoyl)-3-(4-methylphenyl)-1-pyridin-2-yl-1H-pyrazol-5-carboxylic acid 2 and some of their derivatives has been reported recently. However, in that study, keeping the above reports in mind, we investigated the chemical behavior of furandione 1against 2-hydrazinopyridine nucleophile.

2

CH3O

O

O

O

Ar

Ar

1

NHNH2 Ar'

3

a b c

-CH3 -C2H5 -C3H7

N2-7 Ar Ar'

ArO

OHO

NNAr Ar'

46

H3C MgCl

-CO 2

Ar

NO

NNAr Ar'

NR

7a-c

Ar

O

NN

ArAr'

ArCH2

NN

Ar Ar'NN

Ar

Ar OH

CH3

Ar'

R

7 -H -Ph-NO 2 -Pyr

-H2O

ROH

3a-c

5

H5C2 MgCl

NNAr

ArO O

OR'

Ar'

NN

Ph

ArN

OH

NHNH2 Ar'

The structures of all new synthesized products were characterized by 1H-NMR, 13C-NMR, IR spectroscopic data and elemental analyses. Acknowledgements This study was financially supported by Research Foundation of Erciyes University. References [1]. Yıldırım, I.; Kandemirli, F.; Akçamur, Y. J Mol Struct, 2005, 738, 275. [2]. Yıldırım, I.; Kandemirli, F.; Demir, E. Molecules, 2005, 10, 559.


138

PO-7 Synthesis of ruthenium(0) stabilized by N-donor ligand: using as dye in the Dye-

Sensitized Solar Cell (DSSC)* Serkan DAYAN, Nilgun KALAYCIOGLU OZPOZAN

Erciyes University, Faculty of Science, Chemistry Department, Kayseri/ Turkey [email protected] Abstract: Dye-sensitized solar cells (DSSCs), which have emerged as one of the most promising photovoltaic devices, have been studied extensively due to their respectable power conversion efficiency, facile fabrication processes, and potential low cost.1The typical DSSC is, in its original form, composed of dye sensitized nanocrystalline TiO2film as the working electrode, a Pt-coated conductive glass as the counter electrode, and the redox couple I−/I3− in a volatile organic solvent as the electrolyte. For their commercial application, it is important to develop low-cost materials and to achieve maximum efficiency for the cells. [1-3] In this work, ruthenium(0) stabilized by N-donor ligand were successfully synthesized by the reaction of RuCl3, NaBH4 and N-donor ligand. The materials were characterized with FT-IR, BET, SEM-EDX, and TEM. The ruthenium(0) material was tested as photoactive layer in the dye-sensitized solar cell.

* This study is supported by a grant from Scientific Research Projects Committee of Erciyes University ( BAP) with Project Number . References [1] B. O’Regan, M. Grätzel, A low-cost, high-efficiency solar cell based on dye sensitized colloidal TiO2 films, Nature 353 (1991) 737-740. [2] A. Hagfeldt, G. Boschloo, L. Sun, L. Kloo and H. Pettersson, Dye-Sensitized Solar Cells, Chemical Reviews 110 (2010) 6595–6663. [3] J-H. Yum, P. Chen, M. Grätzel, M. K. Nazeeruddin, Recent Developments in Solid-State Dye-Sensitized Solar Cells, ChemSusChem 8-9 (2008) 699-707.


139

PO-8 Magnetic Phosphorus-Containing Polymer for Fast and Selective Solid Phase Extraction

of Trace Amounts of Cd(II) and Pb(II) E. Yilmaz,a R. M. Alosmanovb, M. Soylaka

aErciyes University, Fen Faculty, Department of Chemistry, 38039 Kayseri, Turkey bBaku State University, Chemistry Department, Z. Khalilov str., 23, Baku, Azerbaijan

Abstract

In solid phase extraction (SPE), using a variety of sorbents, it is not always possible to obtain satisfactory recovery of the analytes, and the isolation and the enrichment of individual compounds can be laborious and time consuming. Magnetic adsorbents (MAs) are an alternative to conventional SPE sorbents, and they eliminate these disadvantages. These adsorbents are superparamagnetic, which means that they are attracted to a magnetic field, but retain no residual magnetism after the field is removed [1, 2]. Therefore, suspended superparamagnetic particles adhered to the target can be removed very quickly from a matrix using a magnetic field, but they do not agglomerate after removal of the field. Hence, The use of magnetic adsorbents can significantly shorten the duration of the extraction process [3].

In this study, we report here the synthesis of a new sorbent comprising magnetic phosphorus-containing polymer (M-PhCP) for magnetic solid phase extraction of trace amounts of lead and cadmium in water samples prior to their microsampling flame atomic absorption spectrometric determination. The separation of lead(II) and cadmium(II) adsorbed as 2-(5-bromo-2-pyridylazo)-5-diethylamino-phenol (5-Br-PADAP) chelates on M-PhCP from aqueous solution was simply achieved by applying an external magnetic field via a permanent magnet. The important analytical factors such as pH, amount of adsorbent, eluent concentration and volume, vortex time, ligand volume, and sample volume were investigated and optimized. The influences of matrix components were also investigated. The limit of detection (LOD) of Pb and Cd was 2.7 and 1.1 μg L−1, respectively. The accuracy of the proposed method was proved by analysis of the TMDA-64.2 Lake Ontario water and SPS-WW2 waste water certified reference materials and addition–recovery tests. The method was successfully applied for the determination of lead and cadmium in water samples. References [1] H.H. Yang, S.Q. Zhang, X.L. Chen, Z.X. Zhuang, J.G. Xu, X.R. Wang Magnetite-containing spherical silica nanoparticles for biocatalysis and bioseparations Anal. Chem., 76 (2004), pp. 1316–1321. [2] X.Q. Liu, Z.Y. Ma, J.M. Xing, H.Z. Liu Preparation and characterization of amino-silane modified superparamagnetic silica nanospheres J. Magn. Magn. Mater., 270 (2004), pp. 1–6. [3] A. Denizli, G. Özkan, M.Y. Arica Preparation and characterization of magnetic polymethylmethacrylate microbeads carrying ethylene diamine for removal of Cu(II), Cd(II), Pb(II), and Hg(II) from aqueous solutions J. Appl. Poly. Sci., 78 (2000), pp. 81–89

http://pubs.rsc.org/en/results?searchtext=Author%3AE.%20Yilmaz

http://pubs.rsc.org/en/results?searchtext=Author%3AR.%20M.%20Alosmanov

http://pubs.rsc.org/en/results?searchtext=Author%3AM.%20Soylak

140

PO-9 Dispersive Liquid-Liquid Micro Extraction of Lead(II) for Preconcentration and Separation in

Environmental Samples

M. Soylakand M. Karaca

Erciyes University, Faculty of Sciences, Chemistry Dept., 38039, Kayseri, Turkey

A dispersive liquid-liquid microextraction method for the preconcentration and separation of lead(II) as 2-

hydroxypyridine-3-carboxylic acid chelates has been presented. CCl4 as the extraction solvent and ethanol as

the dispersive solvent were used. The analytical parameters including pH, amount of 2-hydroxypyridine-3-

carboxylic acid, type and volume of extraction solvent, type and volume of dispersive solvent, sample

volume etc which were affected extraction efficiency of lead(II) were optimized. The influences of some

matrix ions were also investigated. The detection limit for lead(II) was 8.3 µg L-1. The preconcentration factor

of the method was 30 The validation of the method was checked by the analysis TMDA-64.2, TMDA 53.3 ve

SPS-WW2 waste water certified references materials and GBW074425 soil, BCR-146 R Sewage sludge from

industrial origin, HR-1 Harbour sediment ve DC73349 Bush branches and leaves certified reference materials.

The method was applied to determination of lead contents of some water, food, soil and sediment samples.

The authors are grateful for the financial support of the Unit of the Scientific Research Project of Erciyes

University (Project no: FYL-2014-5067).

141

PO-10 A DFT (Density Fuctional Theory) on Sabinene and Isoabienol (the Essential Oils of

Juniperus communis) Faik GÖKALP a

a Department of Primary Education, Division of Science Education, Faculty of Education, Kırıkkale

University, TR-71450, Kırıkkale, Turkey Abstract The essential oils of J. communis and its varieties from the region of the world has been determined. In Switzerland, Sabinene is the mainly (32.8) compositions of J. Communis. A result of research releated to this plant is that isoabienol was present in eight species. In the analysis of Ioannou et al.; the percentage of isoabienol is 19.1 %. Our theoretical results show that the stability of Sabinene is more than Isoabienol and the solubilty of Isoabienol in blood is more than Sabinene. References 1. R.P. Adams,Biochem. Syst. Ecol., 2000,28, 515–528. 2. P. Robert, P.S. Adams, Beauchamp, Vasu Dev and Radha M. Bathala; Journal of Essential Oil Research,2010,22,23-28. 3. E. Ioannou, A. Koutsaviti, O. Tzakou, V. Roussis; Phytochem. Rev. 2014, 13, 741.

142

PO-11

A DFT Study of Bromoquinolines Comparison of Experimantal and Theoretical Bioactivities of Bromoquinolines

Salih ÖKTEN*, Faik Gökalp Department of Primary Education, Division of Science Education, Faculty of Education, Kırıkkale University, TR-71450, Kırıkkale,

Turkey Abstract: Quinolines are members of bioactive alkaloids that have long been for their wide range of biological and chemotherapeutic activities. Bromoquinolines are precursors for heterocyclic compounds with multifunctionality. In this study, certain theoretical properties, such as selected bond lengths, bond and dihedral angles, the dipole moment, HOMO, LUMO, and gibbs free energy, dipole moments and geometries for certain bromoquinolines in aqueous and gas phases have been calculated by GAUSSIAN 09 programs and DFT method at the basis set B3LYP.The stabilities of the bromoquinolines were investigated with theoratical and experimental results by comparatively to ascertain any possible correlation. Though the best reactive molecule is 6,8-dibromo-1,2,3,4-tetrahydroquinoline (1), the least compound is 3,6,8-tribromoquinoline (2) depending on its Gibbs Free Energies in aqueous and gas phasesand the difference between HOMO-LUMO. The theoretical results conclude that compound 1 can dissolves in blood and can reach every tissues of the body due to its high dipol moment. Also experimentally, 6,8-dibromo-1,2,3,4-tetrahydroquinoline has the highest inhibition effect on proliferation of various cancer cell lines that confirmed theoretical results.

Scheme1. Molecular structure of 6,8-dibromo-1,2,3,4-tetrahydroquinoline (1) and 3,6,8-tribromoquinoline (2).

References

1. S. Ökten, O. Çakmak, Ş. Tekin, T. K. Köprülü, B. Keskin, A. Saddiqa, S. Duman, M. Çınar, Med. Chem. Res., 2015. Peer reviewing status in the journal.

2. A. Sahin, O. Cakmak, I. Demirtas, S. Ökten, A. Tutar, Tetrahedron, 2008, 64, 10068-10074. 3. S. Ökten, O. Çakmak, R. Erenler, Ş. Tekin, Ö. Yüce, Turk J Chem, 2013, 37(6), 896-908.

143

PO-12 The Structural, Elastic and Electronik Properties of Pd2VAl Compound in Heusler

Structure S. Demir1, O. Örnek2 and N. Arıkan3

1Ahi Evran Üniversitesi, Fen Bilimleri Enstitüsü, 40100 Kırşehir-Turkey 2Ahi Evran Üniversitesi, Mühendislik Mimarlık Fakültesi, Metalurji ve Malzeme Mühendisliği, 40100

Bağbaşı-Kırşehit-Turkey 3 Ahi Evran Üniversitesi Eğitim Fakültesi, İlköğretim Bölümü, 40100 Kırşehir -Turkey

A b s t r a c t

Ab initio calculations have been carried out on the structural, elastic and electronic properties of Pd2VAL

compound in Heusler structure. The calculated lattice constants, bulk modulus, and first order pressure

derivative of the bulk modulus are reported for the L21 structure and compared with previous values. The

numerical first principles calculation of the elastic constants has been used to calculate C11, C12 and C44 for

this compound. The electronic structures of this compound are calculated using the density functional theory,

within a generalized gradient approximation. There is no band gap at the Fermi level. Valance and conduction

bands overlap significantly at the Fermi level.

http://mf.ahievran.edu.tr/index.php/2011-08-28-14-26-00/2012-03-26-05-49-17/2012-03-26-05-49-19

144

PO-13 The First-Principles Study on LuSe Compound in CsCl Structure

Nihat Arıkan1, Osman Örnek2, Şule Uğur3 and Gökay Uğur3

1Ahi Evran Üniversitesi, Eğitim Fakültesi, İlköğretim Bölümü 40100 Kırşehir-Türkiye 2Ahi Evran Üniversitesi, Mühendislik-Mimarlık Fakültesi, Metelurji ve Malzeme Mühendisliği Bölümü,

40100 Kırşehir-Türkiye 3Gazi Üniversitesi, Fen Fakültesi, Fizik Bölümü, Teknikokullar, 06500 Ankara-Türkiye

Abstract

The elastic, electronic, and phonon properties of the intermetallic compounds LuSe in the CsCl structure have

been investigated in detail by employing an ab initio pseudopotential method and a linear-response technique

within a generalized gradient approximation (GGA) of the density-functional theory (DFT) scheme. The

calculated ground-state properties such as lattice constants and bulk modulus agree well with the previous

theoretical calculations. The numerical first-principles calculations of the elastic constants have been used to

calculate C11, C12, and C44 for LuSe. The electronic band structures of LuSe show that at the Fermi level, a

major part of the contribution comes from Lu 5d and Se 4d states. The phonon-dispersion curves and phonon

total and partial density of states based on the linear-response method have been investigated for both

materials. Temperature variations of specific heat capacity in the range of 0–500K are obtained using the

quasi- harmonic model.

145

PO-14 Synthesis and in vitro Antioxidant Properties of New 1-Acetyl-3,4-disubstitue-4,5-

dihydro-1H-1,2,4-triazol-5-ones* Özlem GÜRSOY KOL, Haydar YÜKSEK

Kafkas University, Department of Chemistry, 36100 Kars – Turkey Abstract: Antioxidants are extensively studied for their capacity to protect organism and cell from damage that is induced by the oxidative stress. A great deal of research has been devoted to the study of different types of natural and synthetic antioxidant. A large number of heterocyclic compounds, containing the 1,2,4-triazole ring, are associated with diverse biological properties such as antioxidant, anti-inflammatory, antimicrobial and antiviral activity. Exogenous chemicals and endogenous metabolic processes in human body or in food system might produce highly reactive free radicals, especially oxygen derived radicals, which are capable of oxidizing biomolecules by resulting in cell death and tissue damage. Oxidative damages play a significantly pathological role in human diseases. In this study, seven new 1-acetyl-3-alkyl(aryl)-4-(3-acetoxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones(2) were synthesized by the reactions of 1 type compounds 3-alkyl(aryl)-4-(3-hydroxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones [1] with acetic anhydride. Then, the antioxidant properties of 2 type compounds were studied and evaluated using different three antioxidant assays; including reducing power, free radical scavenging and metal chelating activity [2-4].

1,2 R a CH3 b CH2CH3

c CH2C6H5

d CH2C6H4.CH3 (p-) e CH2C6H4.Cl (p-) f C6H5

g

1 2

N

N

NH

R O

N

OH

N

N

N

R O

N

O

O

O

+ 2(CH3CO)2O

- 2CH3COOH

Figure 1.Synthesis route of compounds 2 *This study was supported by the Scientific and Technological Council of Turkey (Project Number: TBAG 107T247).

References

1. H. Yüksek,Ö. Gürsoy-Kol, M. Elmastaş, M. Calapoğlu, H. Akşit, 5th International Symposium on

Pharmaceutical Sciences, Abstracts, 74, İstanbul, Türkiye, 2007. 2. M. Oyaizu, Japan Nutri. 1986, 44, 307-316. 3. M. S. Blois, Nature,1958, 26, 1199-1200. 4. T.C.P.Dinis, V.M.C. Madeira, L.M. Almeida, Arch. Biochem. Biophys.1994, 315, 161-169.

146

PO-15 Preparation, Characterization and Antimicrobial Activities of Some New Di-[2-(3-

alkyl/aryl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)-azomethin-6-ethoxyphenyl] Isophtalate Derivatives*

Haydar YÜKSEKa, Faruk KARDAŞb, Önder ALBAYRAKc, Muzaffer ALKANc, Fevzi AYTEMİZa

aKafkas University, Department of Chemistry, 36100 Kars – Turkey bErzincan University, Education Faculty, 36100 Erzincan – Turkey

cKafkas University, Education Faculty, 36100 Kars – Turkey Abstract: 1,2,4-Triazole derivatives have drawn considerable attention for the past few decades because of their diverse biological properties. Many 1,2,4-triazole derivatives are found to be potent antioxidant, anti-inflammatory, antimicrobial and antiviral agents. The identification of triazoles and determination of their antibacterial activities are of considerable interest because of the role they play in pharmacological actions [1-4]. This study was planned as two parts; in the first part six new di-[2-(3-alkyl/aryl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)-azomethin-6-ethoxyphenyl]isophtalate (3) were synthesized from the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with di-(2-formyl-6-ethoxyphenyl) isophtalate (2). The structures of six new compounds are established from the spectral data. In the second part of the study, agar hole methods were used to investigate the antibacterial properties of the 3 type compounds against the strains of B. subtilis, Y.enterocolitca, B. cereus, S. aureus, E. coli, P. multocida and K. Pneumoniae. To investigate of the effectiveness level, 0.01 grams of 1,2,4-triazol derivatives dissolved in 1 ml DMSO were tested for 24 hours and the measurement of zone diameters were recorded.

C CO O

O OOC2H5

CHO

H5C2O

OHC

1

NHN

N

NH2

R O

C CO O

O OOC2H5

CH

H5C2O

HC

N N

N NH

NR O

HN N

NO R

2 3 * This study is supported by a grant (Project Number: 2011-FEF-31) from Scientific Research Projects Coordination Unitof Kafkas University.

References 1. M. A. Henen, S. A. A. El Bialy, F. E. Goda, M. N. A. Nasr, H. M. Eisa, Med. Chem. Res.2012, 21, 2368-

2378. 2. B. Kahveci, M. Ozil, E. Mentese, O. Bekircan, K. Buruk, Russ. J. Org. Chem.2008, 44, 1816-1820. 3. Y. Unver, E. Dugdu, K. Sancak, M. Er, S. A. Karaoglu, Turk J. Chem.2009, 33, 135-147. 4. H. Yüksek, O. Akyıldırım, M. L. Yola, Ö. Gürsoy-Kol, M. Çelebier, D. Kart, Archiv der Pharmazie2013,

346, 470-480.

147

PO-16 Synthesis, Spectroscopic and Fluorescence Properties of N,N'-Diethylnicotinamide

Adducts of 2-Bromobenzoates Co(II) and Ni(II)

F. Elif Özbeka Mustafa Yüksekb, Hacali Necefoğluc aChemistry Engineering Department,Engineering and Architecture Faculty, Kafkas University, TR-36300, Kars, Turkey

bElectrical-Electronics Engineering Department, Engineering and Architecture Faculty, Kafkas University, TR-36300, Kars, Turkey

cChemistry Department, Science and Art Faculty, Kafkas University, 36300 Kars, Turkey Abstract: Because of their large applicability areas such as; (1) metal-organic therapeuticals, (2) toxicology and environment, (3) enzymes, proteins, and peptides, (4) molecular recognition, (5) bioanalysis and pharmaceutical sensors, and (6) organometallic light emitting diodes (OLEDs), metal-organic complexes are very attractive and largely investigated materials [1]. Two mixed complexes diaquabis(2-bromobenzoato-κO)bis-(N,N-diethylnicotinamide-κN')cobalt(II) [Co(C7H4BrO2)2(C10H14N2O)(H2O)2] (Complex I) and diaquabis(2-bromobenzoato-κO)bis-(N,N-diethylnicotinamide-κN')nickel(II) [Ni(C7H4BrO2)2(C10H14N2O)(H2O)2] (Complex II) have been synthesized and characterized by elemental analysis, TG/DTA , FT-IR spectra and powder XRD. In addition, the optical absorption and emission properties of metal-organic complexes were investigated by using UV-Vis absorption and fluorescence spectrophotometers, respectively. Complex I showed larger absorption

and emission intensities than complex II in the visible region. This behavior was attributed to the numbers of π π* transitions which are take place in the visible region.

References

1. N. Chavain and C. Biot, Curr. Med. Chem., 2010, 17, 2729.

148

PO-17 A Review on Crystal Structures of N,N'-Diethylnicotinamide Complexes of Metal

Arylcarboxylates Hacali Necefoğlua, F. Elif Özbekb, Mustafa Sertçelikb

cChemistry Department, Science and Art Faculty, Kafkas University, 36300 Kars, Turkey bChemistry Engineering Department, Engineering and Architecture Faculty, Kafkas University, TR-36300, Kars, Turkey

Abstract: N,N-diethylnicotinamide (Dena), a pyridine derivate, is known with the names of Nicotinic acid diethylamide, Nikethamide, N,N diethyl-3-pyridinecarboxamide, coramine, cardiamine. Dena has a respiratory stimulant and analeptic features. The lethal dosage of Dena (Ld50), which is a toxic substance, is 272 ppm in rats. However, the complexes of Dena has different biological properties [1]. Dena coordinates with metals via the pyridine nitrogen atom or the carbonyl oxygene atom. it hasn’t been known any complex that the coordination of this ligand with amid nitrogen. The first complex of Dena whose crystal structure is illuminated by Biguli et al. is mono-(N,N'-diethylnicotinamide)cadmium dithiocyanate [2]. The first metal arylcarboxylate complex of dena is bis(p-hydroxybenzoato)di(N,N'-diethylnicotinamide)copper(II) [3]. There are 46 complexes of Dena with arylcarboxylates. In most of these complexes, dena bonded to a metal atom via nitrogene atom on pyridine ring. When stoichiometric rate of metal:dena is 1:2 in cobalt, nickel, zinc and copper arylcarboxylates complexes of dena, octahedric trans structure is formed. Different metals complexes of same arylcarboxylates are isostructures. It is also found that isotructure complexes of afore-mentioned metals are encountered with dena when the stoichiometry is 1:1. One of the hydroxybenzoate anions is bidentate and the other is monodentate in dimer complex of zinc hydroxybenzoate which is the coordination mode bridging of four arylcarboxylate anion [4]. The metals Ca and Zn complex of dena is an interesting trinuclear complex [5] . Coordination polymer structures are found in complexes wherein the stoichiometric ratio is 1: 1.

References

1. E. Hodgson, R. M. Roe, R. B. Mailman, J. E. Chambers, Dictionary of Toxicology, 2014, Third Edition, Elsevier, p.245. 2. F. Bigoli, A., Braibant, A. Tiripicc et al., Acta Cryst., 1972, B28, 962. 3. F. Valach, M. Dunajjurco, M. Melnik et al., Zeitschrift für Kristallographie, 1994, 209, 267. 4. T. Hokelek, H. Necefoglu, Acta Cryst., 1996, C52, 1128. 5. H. Necefoglu, W. Clegg, A. J. Scott, Acta Cryst., 2002, E58, m123.

149

PO-18 The Effect of Boron Compounds on the levels of L- Carnitine, Leptin, IGF-I and HSP70

in Rat Fed with High-Fat Diet

1Onur ATAKİŞİ1 Kezban YILDIZ DALGINLI 2 Emine ATAKİŞİ 1 Ruya KAYA

1Canan GÜLMEZ

1Departments of Chemistry, Faculty of Science and Letter, 2Departments of Biochemistry, Faculty of

Veterinary Kafkas University, TR-36100, Kars, Turkey Abstract

Obesity has been one of the most important health problems in developing countries. Improper diet habits and

a sedentary lifestyle are the major causes of obesity. In this study, the effects of boron compounds (boric acid

and borax) on the levels of leptin, L-carnitine, insulin-like growth factor 1 (IGF-I) and heat shock proteins

70 (HSP-70) in rats which were fed with high-fat diet for 8 weeks were investigated. Total 60 Sprague

Dawley albino rats were divided into 6 diet groups with different combinations of boron compounds and fat

levels. At the end of the 8-week period, blood samples were taken from the heart under ether anesthesia; and

subsequently serum was obtained. High fat diet significantly increased final body weight of rats relative to the

control group. Levels of leptin and free L-carnitine significantly increased in rats which were fed with high fat

diet (P<0.05; P<0.001) while IGF-I significantly decreased (P <0.001). Boron compounds which were applied

in drinking water had no effect on the levels of serum HSP70 and leptin while decreasingL-carnitine and IGF-

I in rats fed high-fat diet for 8 weeks.

These results suggest that even though boron compounds did not significantly change the weight of the

animals at the end of 8 weeks, they may have adverse effects on obese individuals by decreasing the levels of

serum L-carnitine and IGF-I.

References

1. Nam S, Redeker N, Whittemore R (2015) Social networks and future direction for obesity research: A scoping review. Nurs Outlook 63: 299-317.

2. Hall IH, Reynolds DJ, Wong OT, Sood A, Spielvogel BF (1995) The effects of boron derivatives on lipid absorption from the intestine and on bile lipids and bile acids of sprague dawley rats. Met Based Drugs 2: 65-72.

150

PO-19 Determination of pKa Values of Some 3-Alkyl(Aryl)-4-[3-(2-methylbenzoxy)-

benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones in Non-Aqueus Solvents*

Songül ULUFER, Özlem GÜRSOY KOL

Kafkas University, Department of Chemistry, 36100 Kars – Turkey

Abstract:

In recent years, pKa values of some 1,2,4-triazole and 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives were determined in non-aqueus media 1-3. In this study, in order to determine the pKa values of nine 3-alkyl(aryl)-4-[3-(2-methylbenzoxy)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-one compounds, they were titrated potentiometrically with tetrabutylammonium hydroxide (TBAH) in four non-aqueous solvents such as acetone, isopropyl alcohol, tert-butyl alcohol and N,N-dimethylformamide. For the compounds, the half-neutralization potential (HNP) values and the corresponding pKa values were determined in the four non-aqueous solvents mentioned above. The data obtained from the potentiometric titrations were interpreted, and the effect of substituent, in C-3 position, and solvent effects were studied [1-4]. The compounds used in the study were prepared according to the literature [5].

N

NN

R

O

H

N=CH

O C

OCH3

* This study is supported by a grant (Project Number: 2014-FEF-24) from Scientific Research Projects Coordination Unitof Kafkas University.

References

1. Ö. Gürsoy-Kol, H. Yüksek,F. İslamoğlu, J. Chem. Soc. Pak., 2013, 35, 1179-1190. 2. Ö. Gürsoy-Kol, H. Yüksek,F. İslamoğlu, Revista de Chimie (Rev. Chim.) (Bucharest), 2012, 63, 1103-1111. 3. H. Yüksek, O. Akyıldırım, M. L. Yola, Ö. Gürsoy-Kol, M. Çelebier, D. Kart, Archiv der Pharmazie 2013, 346, 470-480. 4. T. Gündüz, Susuz Ortam Reaksiyonları, Gazi Büro Kitabevi Tic. Ltd. Şti, Ankara, 1988. 5. S. Ulufer, Bazı yeni 4-[3-(2-metilbenzoksi)-benzilidenamino]-4,5-dihidro-1H-1,2,4-triazol-5-on türevlerinin sentezi, yapılarının aydınlatılması ve bazı özelliklerinin incelenmesi, Yüksek Lisans Tezi, Kafkas Üniversitesi Fen Bilimleri Enstitüsü, Kars 2014.

151

PO-20 Synthesis and Antimicrobial Properties of Some Novel 3-Alkyl(Aryl)-4-[3-(3-

nitrobenzoxy)-4-methoxybenzylidenamino]-4,5-dihydro- 1H-1,2,4-triazol-5-ones Fevzi AYTEMİZa, Haydar YÜKSEKa, Önder ALBAYRAKb, Muzaffer ALKANb

aKafkas University, Department of Chemistry, 36100 Kars – Turkey bKafkas University, Education Faculty, 36100 Kars – Turkey

Abstract:

Triazoles are heterocyclic compounds that contain three nitrogen atoms. 1,2,4-Triazole and 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives are reported to possess a broad spectrum of biological activities such as analgesic, antibacterial, antioxidant and antiparasitic properties [1-4]. In this study, nine new 3-alkyl(aryl)-4-[3-(3-nitrobenzoxy)-4-methoxy-benzylidenamino]-4,5-dihidro-1H-1,2,4-triazol-5-one (3) were synthesized from the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with 3-(3-nitrobenzoxy)-4-methoxybenzaldehyde(2). The structures of nine new compounds are established from the spectral data. Then antibacterial properties of 3-alkyl(aryl)-4-[3-(3-nitrobenzoxy)-4-methoxybenzylidenamino]-4,5-dihidro-1H-1,2,4-triazol-5-one (3)compounds by using Agar hole methods of against B. subtilis, Y.enterocolitca, B. cereus, S. aureus, E. coli, P. multocida and K. Pneumoniae strains investigated and data were recorded.

OH

OCH3HOC + CCl

ONO2

Et3N-HCl

OC

OCH3HOC

ONO2

+AcOH

-H2O

2 31

NHN

N

NH2

R O OC

OCH3CH

ONO2

N

NHN

NR O

Figure 1.Synthesis route of compounds 2, 3

References

1. H. Yüksek, O. Akyıldırım, M. L. Yola, Ö. Gürsoy-Kol, M. Çelebier, D. Kart, Archiv der Pharmazie2013, 346, 470-480.

2. Ö. Aktaş-Yokuş, H. Yüksek, Ö. Gürsoy-Kol, Ş. Alpay-Karaoğlu, Med. Chem. Res.2015, DOI: 10.1007/s00044-015-1334-8.

3. N. Chidananda, B. Poojary, V. Sumangala, N. S. Kumari, P. Shetty, T. Arulmoli, Eur. J. Med. Chem. 2012, 51, 124-136.

4. H. A. Saadeh, I. M. Mosleh, A. G. Al-Bakri, M. S. Mubarak, Monatsh. Chem. 2010, 141, 471-478.

http://apps.webofknowledge.com/DaisyOneClickSearch.do?product=WOS&search_mode=DaisyOneClickSearch&colName=WOS&SID=W1igGLHPNFN1jhdekHl&author_name=Poojary,%20B&dais_id=13508299

http://apps.webofknowledge.com/OneClickSearch.do?product=WOS&search_mode=OneClickSearch&colName=WOS&SID=W1igGLHPNFN1jhdekHl&field=AU&value=Sumangala,%20V

http://apps.webofknowledge.com/OneClickSearch.do?product=WOS&search_mode=OneClickSearch&colName=WOS&SID=W1igGLHPNFN1jhdekHl&field=AU&value=Sumangala,%20V

http://apps.webofknowledge.com/OneClickSearch.do?product=WOS&search_mode=OneClickSearch&colName=WOS&SID=W1igGLHPNFN1jhdekHl&field=AU&value=Shetty,%20P

http://apps.webofknowledge.com/OneClickSearch.do?product=WOS&search_mode=OneClickSearch&colName=WOS&SID=W1igGLHPNFN1jhdekHl&field=AU&value=Shetty,%20P

152

PO-21 Antioxidant Activities of Some 3-Alkyl(Aryl)-4-(3-cinnamoyloxy-4-

methoxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones with Their Acidic Properties

Feyzi Sinan Tokalı, Haydar Yüksek, Fevzi Aytemiz

Kafkas University, Department of Chemistry, 36100 Kars – Turkey Abstract: In this study, nine 3-alkyl(aryl)-4-(3-cinnamoyloxy-4-methoxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones were synthesized according to literature [1]. The synthesized compounds were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents such as isopropyl alcohol, tert-butyl alcohol, acetone and N,N-dimethylformamide (DMF), and the half-neutralization potential values and the corresponding pKa values were determined for all cases. The data obtained from the potentiometric titrations were interpreted, and the effect of substituent, in C-3 position, and solvent effects were studied [2-4]. In addition, the antioxidant properties of the compounds were studied and evaluated using different three antioxidant assays; including reducing power, free radical scavenging and metal chelating activity [5-7].

OCCHNHN

N O

N=CH

R

OCH3

CH

O

References

1. Tokalı, F.S., Yüksek, H., Kimya 2011, 25. Uluslararası Katılımlı Ulusal Kimya Kongresi, Erzurum, OP 122, 2011.

2. Yüksek, H., Üçüncü, O., Alkan, M., Ocak, Z., Bahçeci, Ş., “Non-Aqueous Medium Titrations of Some New 4-Benzylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-one Derivatives”, Molecules,10, 961-970 (2005).

3. Alkan, M., Yüksek, H.,İslamoğlu, F., Bahçeci, Ş., Calapoğlu, M., Elmastaş, M., Akşit, H., Özdemir, M.,

“A Study on 4-Acylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones”, Molecules, 12, 1805-1816 (2007). 4. Gündüz, T., Susuz Ortam Reaksiyonları, Gazi Büro Kitabevi Tic. Ltd. Şti, Ankara, 1988. 5. Oyaizu M., Japan Nutri.,44: 307-316, 1986. 6. Blois M.S., Nature,26: 1199-1200, 1958. 7. Dinis T.C.P., Madeira V.M.C., Almeida L.M., Arch Biochem Biophys,315: 161-169, 1994.

153

PO-22 Spectroscopic Properties of 3-Methyl-4-(4-isopropylbenzylidenamino)-4,5-dihydro-1H-

1,2,4-triazol-5-one Molecule* Gül Kotan, Haydar Yüksek

Department of Chemistry, Kafkas University, 36100 Kars, Turkey. E-mail:[email protected]

Isotropic 1H and 13C nuclear magnetic shielding constants of 3-methyl-4-(4-isopropylbenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-onemolecule which was synthesisfical an described in the literature [1]. In this study, the compound was optimized by using the B3LYP/631G (d,p) and HF/631G (d,p) basis sets [2,3]. 1H-NMR and 13C-NMR isotropic shift values were calculated by the method of GIAO using the program package Gaussian G09 [3]. Experimental and theoretical values were inserted into the grafic according to equatation of δ exp=a+b. δ calc. The standard error values were found via SigmaPlot program with regression coefficient of

a and b constants. IR absorption frequencies of analysed molecule were calculated by two methods. The veda4f program, was used in defining IR data, which were calculated theoretically [4]. The experimental and the obtained theoretical values were compared and found by regression analysis that are accurete. Furthermore, UV-Vis values were calculated.

* This study is supported by a grant (Project Number: 2014-FEF-35) from Scientific Research Projects Coordination Unitof Kafkas University. References: 1. Kemer, G.; Bazı Yeni Heterosiklik Bileşiklerin Sentezi ve Bazı Özelliklerinin İncelenmesi Üzerine

Bir Çalışma, Doktora Tezi, Kafkas Üniversitesi Fen Bilimleri Enstitüsü, Kars (2015). 2. M.J.Frisch ve diğerleri, Gaussian G03 Rev. A. CO2, Gaussian, Pittsburgh PA, (2003).

3. Wolinski, K.; Hilton, J.F.; Pulay, P. J. Am. Chem. Soc., 112, 512, (1990).

4. Jamróz, M.H. Vibrational Energy Distribution Analysis: VEDA 4 program, Warsaw, (2004).


154

PO-23 Synthesis and Investigation of Antioxidant Activities of Novel 3-Alkyl(Aryl)-4-2-(3-

methoxybenzoxy)-benzylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-ones Hilal Medetalibeyoğlu, Haydar Yüksek, Özlem Gürsoy-Kol Kafkas University, Dept. of Chemistry, 36100 Kars – Turkey

Abstract:

1,2,4-Triazole and 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives are reported to possess a broad spectrum of biological activities such as antifungal, antimicrobial, hypoglycemic, antihypertensive, analgesic, antiparasitic, hypocholesteremic, antiviral, anti-inflammatory, antitumor and anti-HIV properties [1]. In the present study, eight 3-alkyl(aryl)-4-[2-(3-methoxybenzoxy)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones (1-8) were synthesized and characterized by IR, 1H NMR, 13C NMR and UV spectral data. Then antioxidant activities of 1-8 compounds were investigated. The antioxidant properties of the compounds were studied and evaluated using different three antioxidant assays, including reducing power, free radical scavenging and metal chelating activity. For the measurement of the reductive ability, Fe3+ - Fe2+ transformation was investigated in the presence of compound using by the method of Oyaizu [2]. The hydrogen atoms or electrons donation ability of the synthesized compound was measured by DPPH. using the method of Blois [3]. The chelating effect of ferrous ions by the compound was determined according to the method of Dinis et al [4]. BHT, BHA and α-tocopherol were used as reference antioxidant compounds.

Comp. R

1 CH3

2 CH2CH3

3 CH2CH2CH3

4 CH2C6H5

5 CH2C6H4.CH3 (p-) 6 CH2C6H4.OCH3 (p-) 7 CH2C6H4.Cl (p-) 8 C6H5

1-8

O C

ONHN

N OR

N CH

OCH3

References 1. Yüksek H, Demirbaş A, Ikizler A, Johansson CB, Çelik C, Ikizler AA. Arzneim-Forsch/Drug Res.1997;

47: 405. 2. Oyaizu M. Japan Nutri. 1986; 44: 307-316. 3. Blois MS. Nature, 1958; 26: 1199-1200. 4. Dinis TCP, Madeira VMC, Almeida LM. Arch Biochem Biophys, 1994; 315: 161-169.

155

PO-24 A Study on Theoretical and Experimentical Spectroscopic Properties of 3-n-Propyl-4-3-

(3,5-dinitrobenzoxy)-benzylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-one Molecule

Savaş Kara, Özlem Gürsoy Kol, Haydar Yüksek, Hilal Medetalibeyoğlu Department of Chemistry, Kafkas University, 36100 Kars, Turkey

[email protected]

In this study,3-n-propyl-4-3-(3,5-dinitrobenzoxy)-benzylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-one was synthesized by the reaction of 3-n-propyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-one with 3-(3,5-dinitrobenzoxy)-benzaldehyde [1]. The molecule was optimized by using the B3LYP/631G (d) and HF/631G (d) basis sets [2, 3]. Afterwards, 1H-NMR and 13C-NMR isotropic shift values were calculated by the method of GIAO using the program package Gaussian G09W [2]. Experimental and theoretical values were inserted into the graphic according to equitation of δ exp=a+b. δ calc. The standard error values were found via SigmaPlot program with regression coefficient of a and b constants. Furthermore, molecule’s theoretical bond lengths, UV-Vis values, dipole moments, formal charges, HOMO-LUMO energies, total energy of the molecule, ionization potential, electron affinity and electronegativity for both methods were calculated.

OC

NO2

NO2

N

NN

CH3CH2CH2

O

H

N=CH

O

References:

1. Kara S. “Bazı yeni 4-[3-(3,5-dinitrobenzoksi)-benzilidenamino]-4,5-dihidro-1H-1,2,4-triazol-5-on türevlerinin sentezi ve bazı özelliklerinin incelenmesi”, Yüksek Lisans Tezi, Kafkas Üniversitesi Fen

Bilimleri Enstitüsü, Kars (2013). 2. Frisch, M.J.; Trucks, G.W.; Schlegel, H.B.; Scuseria, G.E.; Robb, M.A.; Cheeseman, J.R., Scalmani, G.;

Barone, V.; Mennucci, B.; Petersson, G.A.; Nakatsuji, H.; Caricato, M.; Li, X.; Hratchian, H.P.; Izmaylov, A.F.; Bloino, J.; Zheng, G.; Sonnenberg, J.L.; Hada, M.; Ehara, M.; Toyota, K.; Fukuda, R.; Hasegawa, J.; Ishida, M.; Nakajima, T.; Honda, Y.; Kitao, O.; Nakai, H.; Vreven, T.; Montgomery, J.A.; Jr.Vreven, T.; Peralta, J.E.; Ogliaro, F.; Bearpark, M.; Heyd, J.J.; Brothers, E.; Kudin, N.; Staroverov, V.N.; Kobayashi, R.; Normand, J., Raghavachari, K.; Rendell, A.; Burant, J.C.; Iyengar, S.S.; Tomasi J.; Cossi, M.; Rega, N.; Millam, J.M.; Klene, M.; Knox, J.E.; Cross J.B.; Bakken, V.; Adamo, C.; Jaramillo, J.; Gomperts, R.; Stratmann, R.E.; Yazyev, O.; Austin, A.J.; Cammi, R.; Pomelli, C.; Ochterski, J.W.; Martin; L.R.; Morokuma, K.; Zakrzewski, V.G.; Voth, G.A.; Salvador, P.; Dannenberg, J.J.; Dapprich, S.; Daniels A.D.; Farkas, O.; Foresman, J.B.; Ortiz, J.V.; Cioslowski, J.; and Fox, D.J. Gaussian Inc., Wallingford, CT., (2009).

3. Wolinski, K.; Hilton, J.F.; Pulay, P.; J. Am. Chem. Soc., 112, 512, (1990).


156

PO-25 Synthesis, Characterization and Antioxidant Activities of {Bis-4-[3-(alkyl(aril)-4,5- dihydro-1H-1,2,4-triazol-5-on-4-yl)-azomethin]phenyl} biphenyl-4,4’disulfonates

Murat Beytur, Haydar Yüksek,Özlem Gürsoy-Kol

Kafkas University, Department of Chemistry, 36100 Kars – Turkey Abstract:

Antioxidants are extensively studied for their capacity to protect organism and cell from damage that is induced by the oxidative stress. A great deal of research has been devoted to the study of different types of natural and synthetic antioxidant. A large number of heterocyclic compounds, containing the 1,2,4-triazole ring, are associated with diverse biological properties such as antioxidant, anti-inflammatory, antimicrobial and antiviral activity. Exogenous chemicals and endogenous metabolic processes in human body or in food system might produce highly reactive free radicals, especially oxygen derived radicals, which are capable of oxidizing biomolecules by resulting in cell death and tissue damage. Oxidative damages play a significantly pathological role in human diseases.

In this study, nine new {Bis-4-[3-(alkyl(aril)-4,5-dihydro-1H-1,2,4-triazol-5-on-4-yl)-azomethin]phenyl} biphenyl-4,4’disulfonates (3) were synthesized by the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with bis (4-formylphenyl) biphenyl-4,4'-disulfonate (2) and characterized by IR, 1H NMR, 13C NMR and UV spectral data. Then the antioxidant properties of the compounds were studied and evaluated using different three antioxidant assays, including reducing power, free radical scavenging and metal chelating activity. For the measurement of the reductive ability, Fe3+ - Fe2+ transformation was investigated in the presence of compound using by the method of Oyaizu [1]. The hydrogen atoms or electrons donation ability of the synthesized compound was measured by DPPH. using the method of Blois [2]. The chelating effect of ferrous ions by the compound was determined according to the method of Dinis et al [3]. BHT, BHA and α-tocopherol were used as reference antioxidant compounds.

S

O

O

O S O

O

O

OHC CHO

1 2

3

+

-H2OAcOH

2

N

NN

R

O

NH2

H

N

NN

R

O

H

N CH S

O

O

O S O

O

O

NHC

N

NN

H

O

R

+OHC OH S

O

O

Cl S Cl

O

O

Et3N

REFERENCES

1. M. Oyaizu, Japan Nutri. 44 (1986) 307-316. 2. M.S. Blois, Nature, 26 (1958) 1199-1200. 3. T.C.P. Dinis, V.M.C. Madeira, L.M. Almeida, Arch Biochem Biophys, 315 (1994) 161-169.

157

PO-26

Synthesis and Antioxidant Activities of N-Acetyl Derivatives Having 4,5-Dihydro-1H-1,2,4-triazol-5-one Ring

Muzaffer Polat, Haydar Yüksek,Murat Beytur, Özlem Gürsoy-Kol, Zeynep Zafer, Savaş Kara

Kafkas University, Department of Chemistry, 36100 Kars – Turkey

Abstract: 1,2,4-Triazole derivatives have drawn considerable attention for the past few decades due to their diverse biological properties. Many 1,2,4-triazole derivatives are found to be potent antioxidant, anti-inflammatory, antimicrobial and antiviral agents. In this study [1], five new 1-acetyl-3-alkyl-4-[3-(3,5-dinitrobenzoxy)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) and five new 1-acetyl-3-alkyl-4-[3-(3,5-dinitrobenzoxy)-4-methoxybenzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones (4) were synthesized by the reactions of 3-alkyl-4-[3-(3,5-dinitrobenzoxy)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) [2] and 3-alkyl-4-[3-(3,5-dinitrobenzoxy)-4-methoxybenzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) [3] with acetic anhydride, respectively. New compounds were characterized by IR, 1H-NMR,13C-NMR and UV spectral data. In addition, the synthesized ten new compounds were analyzed for their in vitro potential antioxidant activities in three different methods, including 1,1-diphhenlyl-2-picryl-hydrazyl free radical (DPPH.) scavenging, reducing activity by Fe+3 –Fe+2 transformation and ferrous metal (Fe+2) chelating activities. Butylated hydroxytoluene (BHT) and α-tocopherol were used as reference antioxidant compounds [4-6].

N

NN

R

O

N

COCH3

CH

OC

NO2

NO2

O

X

N

NN

R

O

N

H

CH

OC

NO2

NO2

O

X(CH3CO)2O

-CH3COOH

1,3 : X= H

2,4 : X= OCH31,2 3,4

References

1. Polat, M., “Bazı yeni 1-asetil-3,4-disubstitue-4,5-dihidro-1H-1,2,4-triazol-5-on türevlerinin sentezi, yapılarının aydınlatılması ve in-vitro antioksidan özelliklerinin incelenmesi”, Yüksek Lisans Tezi,

Kafkas Üniversitesi Fen Bilimleri Enstitüsü, Kars (2014). 2. Kara S. “Bazı yeni 4-[3-(3,5-dinitrobenzoksi)-benzilidenamino]-4,5-dihidro-1H-1,2,4-triazol-5-on

türevlerinin sentezi ve bazı özelliklerinin incelenmesi”, Yüksek Lisans Tezi, Kafkas Üniversitesi Fen

Bilimleri Enstitüsü, Kars (2013). 3. Zafer, Z., “3-Alkil(aril)-4-amino-4,5-dihidro-1H-1,2,4-triazol-5-on bileşiklerinin 3-(3,5-

dinitrobenzoksi)-4-metoksibenzaldehid ile reaksiyonları”, Yüksek Lisans Tezi, Kafkas Üniversitesi Fen Bilimleri Enstitüsü, Kars (2013).

4. M. Oyaizu, Japan Nutri. 44 (1986) 307-316. 5. M.S. Blois, Nature, 26 (1958) 1199-1200. 6. T.C.P. Dinis, V.M.C. Madeira, L.M. Almeida, Arch Biochem Biophys, 315 (1994) 161-169.

158

PO-27 Synthesis and In-Vitro Antioxidant Evaluation of New 1-Acetyl-3-alkyl(aryl)-4-(3-methoxy-

4-acetoxybenzylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-ones* Sevda Manap, Haydar Yüksek, Özlem Gürsoy-Kol

Kafkas University, Department of Chemistry, 36100 Kars – Turkey Abstract: 1,2,4-Triazole and 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives are reported to possess a broad spectrum of biological activities such as antifungal, antimicrobial, hypoglycemic, antihypertensive, analgesic, antiparasitic, hypocholesteremic, antiviral, anti-inflammatory, antitumor and anti-HIV properties [1]. In the present study, five 1-acetyl-3-alkyl(aryl)-4-(3-methoxy-4-acetoxybenzylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl(aryl)-4-(3-methoxy-4-hydroxybenzylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with acetic anhydride [2]. Then antioxidant activities of 2 type compounds were investigated.

The antioxidant properties of the compounds were studied and evaluated using different three antioxidant assays, including reducing power, free radical scavenging and metal chelating activity. For the measurement of the reductive ability, Fe3+ - Fe2+ transformation was investigated in the presence of compound using by the method of Oyaizu [3]. The hydrogen atoms or electrons donation ability of the synthesized compound was measured by DPPH. using the method of Blois [4]. The chelating effect of ferrous ions by the compound was determined according to the method of Dinis et al [5]. BHT, BHA and α-tocopherol were used as reference antioxidant compounds.

CH OCOCH3

OCH3

N

NN O

R N

COCH3

+(CH3CO)2O-CH3COOH

CH OH

OCH3

N

NN O

R N

H

1 2

*This study is supported by a grant (108T984) from TUBİTAK.

References 1. Yüksek H, Demirbaş A, Ikizler A, Johansson CB, Çelik C, Ikizler AA. Arzneim-Forsch/Drug Res.1997;

47: 405. 2. Manap, S., Bazı Yeni 3-Alkil(Aril)-4-(3,4-disubstituebenzilidenamino)-4,5-dihidro-1H-1,2,4-triazol-5-on

Türevlerinin Sentezi, Yapılarının Aydınlatılması, Antioksidan ve Asitlik Özelliklerinin İncelenmesi,

Kafkas Üniversitesi, Mayıs 2009. 3. Oyaizu M. Japan Nutri. 1986; 44: 307-316. 4. Blois MS. Nature, 1958; 26: 1199-1200. 5. Dinis TCP, Madeira VMC, Almeida LM. Arch Biochem Biophys, 1994; 315: 161-169.

159

PO-28 Synthesis and Acidic Properties of Some Novel 3-Alkyl(Aryl)-4-[3-ethoxy-4-(2-

methylbenzoxy)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones

Bahar Bankoğlu,Haydar Yüksek,Sevda Manap

Kafkas University, Department of Chemistry, 36100 Kars – Turkey Abstract:

It is known that 4,5-dihydro-1H-1,2,4-triazol-5-one ring has weak acidic properties, so some 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives were titrated potentiometrically with tetrabutylammonium hydroxide in non-aqueous solvents, and the pKa values of the compounds were determined [1-3]. In the present study, nine new 3-alkyl(aryl)-4-[3-ethoxy-4-(2-methylbenzoxy)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were synthesized from the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with 3-ethoxy-4-(2-methylbenzoxy)-benzaldehyde (2), which was obtained from the reaction of 3-ethoxy-4-hydroxybenzaldehyde with o-methylbenzoyl chloride by using triethylamine. The new compounds synthesized were characterized by using IR, 1H-NMR, 13CNMR and UV spectral data together with elemental analysis. In addition, to investigate the effects of solvents and molecular structure upon acidity [1-4], the prepared 3 type compounds were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents, including acetone, isopropyl alcohol, tert-butyl alcohol and N,N-dimethylformamide. The half-neutralization potential values and the corresponding pKa values were determined for all cases [5].

O C

OCH3

OCH2CH3

N

NN

R

O

N

H

CH

2

+-H2O

31

N

NN

R

O

NH2

H

OHC O C

OCH3

OCH2CH3

References: 1. H. Yüksek, A. Demirbaş, A. İkizler, C.B. Johansson, C. Çelik, A.A. İkizler, Arzneim.-Forsch/Drug Res., 47 (1997) 405-409. 2. Ş. Bahçeci, H. Yüksek, Z. Ocak, İ. Azaklı, M. Alkan, M. Özdemir, Collect. Czech. Chem. Commun., 67 (2002) 1215-1222. 3. Ş. Bahçeci, H. Yüksek, Z. Ocak, C. Köksal, M. Özdemir, Acta Chim. Slov., 49 (2002) 783-794. 4. Gündüz, T., Susuz Ortam Reaksiyonları, Gazi Büro Kitabevi Tic. Ltd. Şti, Ankara, 1988. 5.Bankoğlu, B., 3-Alkil(aril)-4-amino-4,5-dihidro-1H-1,2,4-triazol-5-on’ların 3-etoksi-4-(2-metilbenzoksi)-benzaldehid ile reaksiyonlarının incelenmesi, Kafkas Üniversitesi, Temmuz 2014.

160

PO-29 GIAO NMR Calculations of 3-Ethyl-4-(3-Benzensulfonyloxy-4-

Methoxybenzylidenamino)-4,5-Dihydro-1H-1,2,4-Triazol-5-One*

Özlem Aktaş Yokuş, Haydar Yüksek, Gül Kotan Department of Chemistry, Kafkas University, 36100 Kars, Turkey.


The3-Ethyl-4-(3-benzensulfoniloxy-4-methoxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-onehas been optimized using B3LYP/631G (d,p) and HF/631G (d,p) basis set [1]. Starting from this optimized structure with 1H-NMR and 13C-NMR and IR spectral data values according to GIAO [2] method was calculated using the method of Gaussian G09W program package in gas phase. Theoretically and experimentally values were plotted according to exp =a +b. δ calc Eq. a and b constants regression coefficients with a standard error values were found using the SigmaPlot program. Theoretically calculated IR data are multiplied with appropriate adjustment factors and the data obtained according to HF and DFT method are formed using theoretical infrared spectrum. The identification of calculated IR data was used in veda4f program [3]. Experimentally and theoretically UV-vis values in ethanol were calculated and compared.

The title compoundwas synthesized by the reaction of 3-ethyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-one with 3-

benzensulfoniloxy-4-methoxybenzaldehyde [4]. * This study is supported by a grant (Project Number: 2011-FEF-32) from Scientific Research Projects Coordination Unitof Kafkas University.

1. Frisch, M.J.; Trucks, G.W.; Schlegel, H.B.; Scuseria, G.E.; Robb, M.A.; Cheeseman, J.R., Scalmani, G.; Barone, V.; Mennucci, B.; Petersson, G.A.; Nakatsuji, H.; Caricato, M.; Li, X.; Hratchian, H.P.; Izmaylov, A.F.; Bloino, J.; Zheng, G.; Sonnenberg, J.L.; Hada, M.; Ehara, M.; Toyota, K.; Fukuda, R.; Hasegawa, J.; Ishida, M.; Nakajima, T.; Honda, Y.; Kitao, O.; Nakai, H.; Vreven, T.; Montgomery, J.A.; Jr.Vreven, T.; Peralta, J.E.; Ogliaro, F.; Bearpark, M.; Heyd, J.J.; Brothers, E.; Kudin, N.; Staroverov, V.N.; Kobayashi, R.; Normand, J., Raghavachari, K.; Rendell, A.; Burant, J.C.; Iyengar, S.S.; Tomasi J.; Cossi, M.; Rega, N.; Millam, J.M.; Klene, M.; Knox, J.E.; Cross J.B.; Bakken, V.; Adamo, C.; Jaramillo, J.; Gomperts, R.; Stratmann, R.E.; Yazyev, O.; Austin, A.J.; Cammi, R.; Pomelli, C.; Ochterski, J.W.; Martin; L.R.; Morokuma, K.; Zakrzewski, V.G.; Voth, G.A.; Salvador, P.; Dannenberg, J.J.; Dapprich, S.; Daniels A.D.; Farkas, O.; Foresman, J.B.; Ortiz, J.V.; Cioslowski, J.; and Fox, D.J. Gaussian Inc., Wallingford, CT., 2009.

2. Wolinski, K.; Hilton, J.F.; Pulay, P. J. Am. Chem. Soc., 112, 512, (1990). 3. Jamróz, M.H. Vibrational Energy Distribution Analysis: VEDA 4 program, Warsaw, (2004). 4. Yokuş, Ö. A., “Bazı yeni 1,2,4-triazol türevlerinin sentezi ve biyolojik aktivitelerinin incelenmesi”,

Doktora Tezi, Kafkas Üniversitesi Fen Bilimleri Enstitüsü, Kars (2012).

N

NN

CH3CH2

O

H

N=CH OCH3

O

S OO


161

PO-30 Prophylactic Effect of Beta Carotene on the Diethylnitrosamine-Induced Oxidative

Stress in Rabbit

1Onur ATAKİŞİ2Oğuz MERHAN 2Emine ATAKİŞİ 2Ayla ÖZCAN

3Necati KAYA 4Cem ÖZİÇ 1Departments of Chemistry, Faculty of Science and Letter, 2Departments of Biochemistry, Faculty of

Veterinary Kafkas University, Kars, Turkey 3Celal Bayar Univ, Vocat Sch Hlth Serv, Manisa, Turkey 4Kafkas Univ, Fac Engn & Architecture Dept Bioengn, Kars, Turkey

Abstract: N-nitroso compounds are also known as carcinogens and could be found in different types of

foodstuff including, meat, salted fish, alcoholic beverages and several vegetables. Both environmental and

food-born N-nitrosamines pose a health risk for human and animals. Beta-carotene is an antioxidant which

protects the organism from free radicals molecules. Free radicals damage cells through a process known as

oxidation.

The aim of this study was to investigate the effect of beta-carotene on the levels of nitric oxide (NO), total

antioxidant status (TAS) and total oxidant status (TOS) with respect to diethylnitrosamine (DEN) toxicity in

rabbits. Twenty four rabbits were used as materials. The rabbits were divided into 3 groups. Group I: injected

with single dose of saline via intraperitoneally (i.p). Group II: DEN at a dose of 100mg/kg/body weight (i.p).

Group III: single injection (i.p) at 100mg/kg/body weight DEN plus (at a dose of 2 mg/kg/day via orally in

beta-carotene) for 7days. Plasma TAS levels were found to be significantly lower in diethylnitrosamine

treated group than those of control group (P<0.05). TAS levels in group III were found to be not significant

compared to control group. Plasma TOS levels did not change among the experimental groups. Nitric oxide

levels were statistically (P<0.05) higher in group II and III than that of group I.

In conclusion diethylnitrosamine toxication reduces the status of antioxidants. It can be thought that

exogenous beta-carotene supplementation could be beneficial and effective for decreasing oxidative stress and

improve antioxidants defense system against diethylnitrosamine toxication and improving antioxidant status

References:

1. Atakisi, O., E. Atakisi, A. Ozcan, M. Karapehlivan, A. Kart, “Protective effect of omega-3 fatty acids on diethylnitrosamine toxicity in rats”, Eur. Rev. Med. Pharmacol. Sci., 14, 467-471, (2013).

162

PO-31 The Effect of Goji Berry Extract on Liver Enzyme Activity and Antioxidant System in

Carbon Tetrachloride Toxicity Ayşe KANICIa, Onur ATAKİŞİb, Nurgül ATMACAc, Füsun TEMAMOĞULLARId, Yeşim AYDINb,

Yonca YILMAZb

aDepartment of Pharmacology and Toxicology, Faculty of Veterinary, Kafkas Üniversity, TR-36000, Kars, Turkey

bDepartment of Chemistry, Faculty of Science and Letter, Kafkas Üniversity, TR-36000, Kars, Turkey cDepartment of Physiology, Faculty of Veterinary, Kırıkkale University, TR-71000, Kırıkkale, Turkey d Department of Pharmacology and Toxicology, Faculty of Veterinary, Harran Üniversity, TR-63000,

Şanlıurfa, Turkey

Abstract: The aim of the present study was to investigate the antioxidant effect of goji berry (GB) extract in a mouse model of CCl4-induced oxidative injury. GB fruit extracts (without pesticide/contaminating substance) were used in the study. Mice were fed ad libitum. Animals were divided into four experimental groups (n=10/group) as follows: Group1 (control), Group2 (GB extract), Group3(GB+CCl4), and Group4 (CCl4 only). Animals in Group 1 received saline solution (0.5 ml/kg c.a., i.p.) every second day for a period of 90 days. Animals in Group 2 and Group 3 received GB extract (200 mg/kg c.a., i.p.) every second day for a period of 90 days. At the end of 90 days, animals in Group 3 and Group 4 received a single-dose of CCl4 (0.25 ml/kg c.a.). Twenty-four hours later, approximately 0.5 ml blood samples were collected into heparin-containing tubes, and plasma samples were isolated. Commercial, spectrophotometric kits were used to measure total oxidant status (TOS), total antioxidant status (TAS), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) activities. ALT, AST, and GGT activities in Group 3 were significantly lower compared to Group 4 (p<0.001). On the contrary, ALT, AST, and GGT activities in Group 3 were significantly higher compared to Group 1 (p<0.001). TOS levels in Group 3 were significantly lower, compared to Group 4. On the other hand, TOS levels in this group were higher compared to Group 1 and Group 2 (p>0.05). TAS levels in Group 3 and Group 4 were significantly lower, compared to Group 1 and Group 2 (p<0.01). Our results indicate that: i) long-term treatment with GB extract may prevent an excess increase in AST, ALT, and GGT enzyme activities in CCl4toxicity, and ii) GB extract can prevent the formation of oxidant molecules by supporting the antioxidant system. Taken together, GB extract can be used as an alternative protection mechanism against CCl4 toxicity. References

1. Harunobu Amagase, Norman R. Farnsworth, Food Research International, 2011, 1702-1717. 2. Q.Luo et al., Life Science, 2004, 76, 137-149.

163

PO-32 Synthesis and Non-Aqueus Medium Titrations of Some Novel 3-Alkyl(Aryl)-4-[2-(2-

furylcarbonyloxy)-3-methoxybenzylidenamino)]-4,5-dihydro-1H-1,2,4-triazol-5-ones*

Muzaffer Alkana,Haydar Yüksekb, Abdurrahman Gürbüzc

aKafkas University, Education Faculty, 36100 Kars – Turkey bKafkas University, Department of Chemistry, 36100 Kars – Turkey

cKafkas University, Atatürk Health Services VC, 36100 Kars – Turkey

Abstract: Several articles, involving the determination of pKa values of some 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives, have been published up to the present [1-3]. In this study, in order to determine the pKa values of compounds 3, they were titrated potentiometrically with tetrabutylammonium hydroxide (TBAH) in four non-aqueous solvents such as acetone, isopropyl alcohol, tert-butyl alcohol and N,N-dimethylformamide. For compounds 3, the half-neutralization potential (HNP) values and the corresponding pKa values were determined in the four non-aqueous solvents mentioned above. The data obtained from the potentiometric titrations were interpreted, and the effect of substituent, in C-3 position, and solvent effects were studied [1-4]. The new compounds 3-Alkyl(Aryl)-4-[2-(2-furylcarbonyloxy)-3-methoxybenzylidenamino)]-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were synthesized were synthesized from the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with 2-(2-furylcarbonyloxy)-3-methoxybenzaldehyde (2) [5].

1

NHN

N

NH2

R O

2 3

NHN

N

N

R O

CH

O

OCH3

O C

O

O

C OCH3H

OO C

O

*This study is supported by a grant (107T633) fromTUBİTAK.

1. İkizler, A.A., Erdoğan, Y., Doğa-Tr. J. of Chem., 1991, 15, 337. 2. Bahçeci, Ş., Yüksek, H., Ocak, Z., Azaklı, İ., Alkan, M., Özdemir, M., Collect. Czech. Chem. Commun., 2002, 67, 1215. 3.Yüksek, H., Alkan, M., İslamoğlu, F., Bahçeci, Ş., Elmastaş, M., Calapoğlu, M., Özdemir, M., Asian J. Chem ., 20, 5311-5321 (2008). 4. Gündüz, T., Susuz Ortam Reaksiyonları, Gazi Büro Kitabevi Tic. Ltd. Şti, Ankara, 1988. 5. Özdemir, G., Yüksek, H., Beytur, M., International Symposium on Molecular Chemistry, İstanbul, PP-98, December

18-19, 2014.

164

PO-33 Effect of substrate temperature on the functional properties of Vanadium Oxide thin

films grown by spray pyrolysis method Mustafa SAĞLAMand Betül GÜZELDİR

Department of Physics,Faculty of Science, Atatürk University, TR-25240, Erzurum, Turkey Abstract: In this study, vanadium oxide thin films were deposited on glass substrates at different substrate temperature by spray pyrolysis method. The influence of substrate temperature on structural, morphological and optic properties of thin films deposited by spray pyrolysis was investigated. For this purpose, the crystal structure and grain sizes of the films were investigated by X-ray diffraction (XRD) analysis and all the films were polycrystalline. The shapes, sizes and distributions of the surface formed on the grains of the films were investigated by scanning electron microscopy (SEM) and atomic force microscopes (AFM). From the results of the absorption measurements, the decrease in bandgap values was observed with the increase of substrate temperature. As a result of this analysis, it can be said that substrate temperature has major effect on the structural, morphological, electrical and optical properties of the films.

165

PO-34 Chemical effect on the atomic and molecular cross sections of some Ce compounds near

the K edge Rıdvan DURAKa, Ferdi AKMANb

aDepartment of Physics,Faculty of Science, Atatürk University, 25240, Erzurum, Turkey bDepartment of Electronic Communication Technology, Vocational School of Technical Sciences,Bingöl University, 12000, Bingöl, Turkey

Abstract:

The absorption of X-rays in materials has been an important topic in the field of radiation physics and chemistry. X-ray

absorption parameters such as mass attenuation coefficient, atomic, molecular and electronic cross sections, effective atomic number and electron density are important in the field of interaction of X-rays with matter. These parameters should be known accurately, since the interaction of X-ray with matter has wide application fields such as atomic, molecular and radiation physics, X-ray fluorescence surface chemical analysis, cancer therapy, dosimetric computations for health physics and space explanation.

In this study, the atomic and molecular cross sections were determined using the experimental total mass attenuation coefficients near the K edge in X-ray energy range from 31.817 to 51.698 keV for Ce2O3, Ce(OH)4, Ce(SO4)2 and CeCl3.7H2O compounds. The measurements were performed in a transmission geometry using the Kα2, Kα1, Kβ1 and Kβ2 X-rays from the different secondary source targets excited by the 59.54 keV photons from an annular Am-241 source. The energy gap, ionization energy, electron affinity and global electrophilicity values of oxide, sulphate, chloride and hydroxide ions were calculated utilizing the density functional theory (DFT/B3LYP). The experimental results of atomic and molecular cross sections were discussed based on these parameters. Also, the results were compared with the theoretical calculations.

*This work was done with the support of the Atatürk University Research Fund under Project no. 2011/82.

166

PO-35 Magnetically Separable Graphene Oxide-Fe3O4 Nanocomposites for Photocatalytic

Degradation of Methylene Blue under UV Irradiation Tuba Ezgi TÜZEMEN, Kübra BİLMİŞOĞLU, Ayşe Merve ASLANDAŞ, Murat KIRANŞAN,Kadem MERAL

Department of Chemistry,Faculty of Science, Atatürk University, TR-25240, Erzurum, Turkey

[email protected], [email protected], [email protected] Abstract:

The requirement for fresh water has crucial role for human beings, and its availability is a big problem at present. Since dye compounds are extensively used in many important industries such as textile, plastics, paint, leather, andcosmetics,1 this causes critical environmental problems such as pollution of ground water resources. In this regard, several techniques such as photocatalytic degradation,adsorption, and biological treatment have been employed toremove dyes from industrial wastewaters.The photocatalytic degradation method is the most convenientone considering its efficiency, practicability, and low cost.2 In the present study, the photocatalytic degradation of Methylene Blue (MB)as pollutant under UV irradiation is studied in the presence of magnetically separable graphene oxide-Fe3O4 (GO-Fe3O4) nanocomposites. The effects of the amount of GO-Fe3O4 nanocomposites, MB concentration, pH, irradiation time and UV wavelength on the photocatalytic degradation of MB are explored. It is determined that the GO-Fe3O4 nanocomposites show an excellent photocatalytic activity for the photocatalytic degradation of MB (Fig. 1).

Fig. 1. Degradation efficiency (%) of the GO-Fe3O4 nanocomposites

References

1. M. S. Chiou, P. Y. Ho, H. Y. Li, Dyes & Pigments, 2004, 60, 69. 2. T. Peik-See, A. Pandikumar, L. H. Ngee, H. N. Ming, C. C. Hua, Catal. Sci. Technol., 2014, 4, 4396.

167

PO-36 A Facile Synthesis of Fluorescent Carbon Dots from Blueberry and Their Performance

in Fe3+ Detection

Ayşe Merve ASLANDAŞ, Neslihan BALCI, Mustafa ARIK, Halis ŞAKIROĞLU, Yavuz ONGANER,Kadem MERAL

Department of Chemistry,Faculty of Science, Atatürk University, TR-25240, Erzurum, Turkey [email protected], [email protected]

Abstract: Carbon nanoparticles (C-dots), as a new type of carbon-based nanomaterials, have attracted great attention due to their unique optical/chemical properties.1 C-dots have potential applications in various fields, e.g. bio-imaging, optoelectronic devices, sensors, drug delivery, antimicrobial activity and photocatalysis. The fluorescent C-dots show distinguished properties such as stable photoluminescence, tunable emission, chemical inertness, aqueous solubility, easy functionalization, good biocompatibility and low toxicity.2 In the present study, the fluorescent C-dots are synthesized by a facile method containing liquid N2 treatment. The photophysical properties of the C-dots in an aqueous solution areexplored by using UV-Vis absorption, fluorescence and time-resolved fluorescence spectroscopies. The C-dots emit a broad fluorescence between approximately 350-550 nm and their fluorescence is tuned by changing excitation wavelength. The as-prepared C-dots are applied to Fe3+detection from aqueous solution.

Fig. 1. (a) UV−Vis absorption and (b) fluorescence spectra of the C-dots

References

1. Y. Wang and A. Hu, J. Mater. Chem. C, 2014, 2, 6921. 2. Q. Liang, W. Ma, Y. Shi, Z. Li and X. Yang, Carbon,2013, 60,421.

168

PO-37 Effects of Metal Ions on Binding Constants of Coumarine 35 to BSA and DNA

Tuğba BAYRAKTUTAN, Yavuz ONGANERa aDepartment of Chemistry,Faculty of Science, Atatürk University,TR-25240Erzurum, Turkey

Abstract: Effects of common metal ions on the interaction mechanism between coumarin 35 (C35)-Bovine Serum Albumin (BSA) and C35-DNA were studied by using UV-Vis absorption and fluorescence spectroscopic techniques. The metal ions have a significant role for changes in the distribution and binding mechanism of BSA and DNA. Recently, many studies related to various coumarin derivatives have been published because of biological important. They are used analgesics, anticoagulants, fluorescence probes and sensitizer in photo processes.1,2Therefore, the photophysical properties and binding properties of C35 with macromolecules in various solvent are sdutied.3,4,5 The molecular structure of C35 is shown in Fig. 1. The effects of thirteen metal ions (K+1, Li+1, NH4

+1,Ca+2, Ba+2, Mg+2, Sr+2, Mn+2, Fe+2, Ni+2, Al+3, Fe+3, Sn+4 ) on the BSA-C35 and DNA-C35 systems were studied, and determined on the changes of the binding constants by Scatchard method.

Fig. 1. The molecular structure of coumarin 35 compounds. Carbon atoms are shown in gray, hydrogen is white, nitrogen is blue and oxygen is red.

References

1. Toprak M.; Arık M.Turk J Chem.2010, 34, 285 – 293. 2. Novo M.; Al-Soufi, W. 11th International Electronic Conference on Synthetic Organic Chemistry

(ECSOC 11) 2007. 3. Nad, S.; Kumbhakar, M.; Pal, H.; Journal of Physical Chemistry A 2003,107, 4808-4816. 4. Jones, G.; Rahman, M. A. Journal of Physical Chemistry 1994, 98, 13028-13037. 5. Das, K.; Jain, B.; Patel H. S. Journal of Physical Chemistry A 2006, 110, 1698-1704.

169

PO-38 The Effect of Organized Surfactant Media on Energy Transfer Between Coumarin 120

and Safranine T Molecules* Ebru BOZKURTa, Kadem MERALb, Yavuz ONGANERb

aDepartment of Occupational Health and Safety, Erzurum Vocational Training School, Atatürk University, TR-25240 Erzurum, Turkey

bDepartment of Chemistry, Faculty of Science, Atatürk University, TR-25240 Erzurum, Turkey Abstract:

FRET is a physicochemical process by the intermolecular energy transfer from the fluorescence of the molecule (donor) to another molecule (acceptor) as nonradiative1. The energy transfer studies are generally achieved in pure water media. However, the donor-acceptor systems in which high yield energy transfer cannot be obtained in pure water media are also available. The reverse micelles which environments can change distance between the donor and the acceptor can be used to increase the energy transfer efficiency of these systems. The reverse micelle structures occur from the polar solvent (usually water) pools wrapped by surfactants dispersed in a nonpolar organic solvent2. The size of the media (water pools) in which the energy transfer occurs can be controlled.

In this study, the fluorescence energy transfer between coumarin-120 (donor)andsafranine-T (acceptor)has been investigated in the reverse micelles including the different nano-scale water pools media. The efficiency of energy transfer is increased by using reverse micelle solutions.

Scheme. The fluorescence energy transfer between coumarin-120 and safranine-T.

*This study is supported by a grant (Project Number:2014/187) from Scientific Research Projects Committee of Atatürk University

References

1. S. Chatterjee, S. Nandi, S. C. Bhattacharya, “J. Photochem. and Photobio. A: Chem. 2005, 173, 221–

227.

2. M.P. Pileni, J. Phys. Chem.1993, 97, 6961–6973.

170

PO-39 Interactions between Fluorescein and Safranine T in PC Liposomes

Ebru BOZKURTa, Tuğba BAYRAKTUTANb, Murat ACARb, Mahmut TOPRAKc aDepartment of Occupational Health and Safety, Erzurum Vocational Training School, Atatürk University, TR-25240 Erzurum,Turkey

bDepartment of Chemistry, Faculty of Science, Atatürk University, TR-25240 Erzurum,Turkey cDepartment of Chemistry, Faculty of Art and Science, Bingol University, TR-12000 Bingol,Turkey

Abstract: The fluorescence quenching technique provides information regarding complex macromolecular systems, which are both chemical and biological in nature. This technique is an appropriate method to determine molecular distribution between the aqueous and lipid phases. Moreover, the extent of the quenching of the molecules portions in the bilayer provides information on the concentration, penetration, and mobility of the quencher in the membrane. The quencher of molecules on the membrane causes a decrease in the fluorescence intensity of the fluorophore, and this in turn provides information regarding the average number of quencher molecules on the membrane. This partition plays an important role in understanding the molecular mechanism of drugs, toxicity and the dye of the substances in the cell membrane1, 2. In this study, the fluorescence quenching of fluorescein by safranine T in liposome media had been investigated systematically by fluorescence spectroscopy, UV–vis absorption spectroscopy and fluorescence decay lifetime measurements. The spectroscopic data were analyzed using a Stern–Volmer equation to determine the quenching process. The experimental results showed that the intrinsic fluorescence of fluorescein was strongly quenched by safranine T, and that the quenching mechanism was considered as static quenching by forming a ground-complex.

Scheme.General representation of the liposome.

References

1. D.T. Cramb, S.C. Beck, J. Photochem. Photobiol. A: Chem.2000, 134, 87–95. 2.J.L. Vazquez, M.T. Montero, J. Trias, J. Hernandez-Borrell, Int. J. Pharmaceut.1998, 171, 75–86. 3.S.K. Ghosh, S.C. Bhattacharya, Chem. Phys. Lipids, 2004, 131, 151–158.

171

PO-40 Synthesis of Halo- and Aminocyclitols Containing Eight-Membered Ring

Emine Salamcı

a, Ufuk Nusret Karavaizoğlu

a, Yunus Zozikb

aDepartment of Chemistry, Faculty of Sciences, Atatürk University 25240 Erzurum/TURKEY bAtatürk University,

Oltu Vocat Training Sch, 25400 Erzurum/TURKEY

[email protected] Halo- and aminocyclooctanols are a class of polyhydroxylated cyclooctanes.1-3 Aminocyclitols are core units in various bioactive compounds, e.g. aminoglycoside antibiotics and antiviral nucleosides.4,5 These compounds are important because of using as glycosidase inhibitors. Various methods are already available for the construction of functionalized five-and six-membered rings from sugars but only a few approaches have been reported for the synthesis of eight-membered ring aminocyclitols.2,3

A concise and efficient synthesis of halo- and aminocyclitols containing eight-membered carbocycles are described starting from cis,cis-1,3-cyclooctadiene. Initially, cyclooctene endoperoxide obtained by photooxygenation of cis,cis-1,3-cyclooctadiene was the key compound in the synthesis.3 As a result of various chemical transformation of cyclooctene endoperoxide resulted in formation of, 3-bromo- (1), 3-chloro- (1) and 3-aminocyclooctanetriols (1) in high yield and stereospecifically. In the second part of study, the corresponding azidoalcohol was obtained by the reaction of 1,3-cyclooctadiene with m-CPBA and NaN3. Epoxyaminocyclooctanol (2), 3-amino- (1) and 2-aminocyclooctanetriols (3) were synthesized via various reactions of azidoalcohol epoxide which is formed by epoxidation of azidoalcohol. Acknowledgment: The authors are indebted to the Department of Chemistry (Atatürk University, Grant No: BAP-2013/290) and Scientific and Technological Research Council of Turkey (TUBITAK, Grant No: 110T208) for their financial support of this work. References: 1. (a) T. Posternak, The Cyclitols, French ed., Hermann: Paris, 1965. (b) E. Salamci, H. Seçen, Y. Sütbeyaz,

M. Balci, J. Org. Chem., 1997, 62, 2453-2457. (c) A. Delgado, Eur. J. Org. Chem., 2008, 23, 3893-3906. 2. K. Ecer, E. Salamci, Tetrahedron, 2014, 70(44), 8389-8396. 3. E. Salamci, Tetrahedron, 2010, 66(23), 4010-4015. 4. S. Grabowski, J. Armbruster, H. Prinzbach, Tetrahedron Lett., 1997, 38, 5485-5488. 5. A. Gypser, D. Michel, D. S. Nirschi, K. B. J. Sharpless, J. Org. Chem., 1998, 63, 7322-7327.


172

PO-41 Fabrication and Neutron Dose Rate Measurements of a Ni based New Super Alloy

including W, Cr, and Cu

Abdulhalik KARABULUTa, Turgay KORKUTb, Bünyamin AYGÜNa aDepartment of Physics, Faculty of Science Atatürk University, 25040, Erzurum, Turkey bSinop Univ, Fac Engn, Dept Nucl Energy Engn, Sinop Turkey Abstract: Ni based new sample was produced by powder metallurgy technique. Mechanical and chemical resistance tests were performed. To have information on the neutron shielding performance of produced new alloy, neutron equivalent dose rate measurements were made using 241AmBe neutron source and Canberra NP100B neutron type neutron counter. Also GEANT4 Monte Carlo simulations conducted to obtain total neutron macroscopic cross section value. Experimental results and simulations were compared to 316LN nuclear grade steel sample. As a result, an increase of14.67per centwas achievedfor thecross sectionvalue.

*This work was supported by The Turkish Scientific and Technological Research Council of Turkey (TUBITAK) (Project No. 111T764). The authors wish to thank to TUBITAK.

173

PO-42 Synthesis of 5-(5-Oxo-Pyrrolidin-2-yloxymethyl)-Furan-2-CarbaldehydeDerivatives

Nurhan KİSHALI, Özlem GÜNDOĞDU, Pınar AYDIN, Yunus KARA Department of Chemistry, Faculty of Sciences, Atatürk University, TR-25240, Erzurum,Turkey

Abstract: 5-(5-oxo-pyrrolidin-2-yloxymethyl)-furan-2-carbaldehyde (1) was known Sessiline. Sessiline (1) is an alkaloide. It was isolated from

the fruits of Acanthopanax sessiliflorus, a herbaceous plant, which is indigenous in East Asia [1]. The first, simple synthesis of

Sessiline has been prepared from succinimide and furfuryl alcohol [2]. Here, we report a synthesis of a series of new Sessiline

analogues (2), and the characterization of the products.

NH

O O

OCHO

NR

O

OO

Sessiline (1) 2

CHOR= -MeR= -EtR= -Ph

Figure 1.

References

1. Perry, L.M. Medicinal Plants of East and Souutheast Asia, MIT press, Cambridge, Massachussetts, London; 1980, p, 41.

2. Ilkei, V.; Farago, K.; Santa, Z.; Dekany, M.; Hazai, L.; Szantay, C.J.; Szantay, C.; Kalaus, G. Int. J. of Org. Chem. 2014, 4, 309-313.

174

PO-43 Synthesis of New Norbornanoıd Chiral Compounds via Desymmetrization of 1, 2-Vinyl

Dibromides Ramazan Koçaka, Arif Daştana, Giuseppe Borsatob, Ottorino De Lucchib

a) Ataturk University, Science Faculty, Department of Chemistry, 25240, Erzurum, Turkey.

b) Dipartimento di Scienze Molecolari e Nanosistemi, Università Ca’ Foscari di Venezia, Dorsoduro 2137, I-30123 Venezia,

Italy. Abstract: The use of polycyclic ketones as intermediates in asymmetric synthesis is one of the cornerstones of organic chemistry since the first synthesis of prostaglandins developed at the end of sixties.The polycyclic ketones are known for their biological activity, for

example as inhibitor of -secretase,cannabinoid receptor ligand and calcium channel blockers.1As displayed in Scheme1, in this study five polycyclic dibromoolefins have been submitted to desymmetrization by (-)-ephedrine to polycyclic ketones 3.2In addition to this,one of the target compound 3a was functionalised to amino alcohol 6a that is analogue of Noyori’s DAİB organocatalyst3 by three step reaction in high yield.

Scheme 1

*The authors are indebted to the Scientific and Technical Research Council of Turkey (TUBITAK project NO: TBAG-110T091) for their financial support.

References

1. (a) E. J. Corey, T. K. Schaaf, W. Huber, U. Koelliker, N. M. Weinshenker,J.Am.Chem. Soc. 1970, 92, 397-398; (b) M. Muthuppalaniappan, G. Balasubramanian, S. Gullapalli, N. K. Joshi, S. Narayanan, US 2008 0234259A1, 2008. 2. R. Koçak, G. Borsato, O. De Lucchi, A. Daştan, Helv. Chim. Acta,2014, 97, 537-545. 3.M. Kitamura, S. Suga, K. Kawai, R. Noyori,J. Am. Chem. Soc. 1986, 108, 6071-6072.

175

PO-44 An Efficient Synthesis of Substituted Naphthalenesand Anthracenes*

Esra TURAN AKIN, Musa ERDOĞAN, Ramazan KOÇAK,Nurullah SARAÇOĞLU, Arif DAŞTAN

Ataturk University, Facultyof Sciences, Department of Chemistry, 25240, Erzurum, Turkey.

Abstract: Naphthalene and anthracene derivatives are very important in organic, bioorganic, organometallic and material chemistry.1,2 There are several reports on the synthesis of these kind of molecules. However, a particular synthesis to substitute in certain positions of these molecules is still challenging problem. Generally, classical bromination reactions for naphthalene and anthracene result in a mixture of products.3Thus it is very important to search for a convenient and efficient method for the synthesis of these types of compounds. In this study, substituted naphthalenes and anthraceneswere obtained by cycloaddition reaction of benzobarralenes1and dibenzobarralenes 5 with tetrazine2 followed by retro-Diels-Alder reaction.

*This study is supported by TUBİTAK (Project Number: 112T341). We would like to extremely thank to

TUBİTAK for their financial support of this work. References

1. Mahabusarakam, W., Hemtasin, C., Chakthong, S., Voravuthikunchai, S. P., Olawumi, I. B., Planta Med. 2010, 76, 345-349. 2. (a) Cantrell, G. L., Filler, R., J. Fluorine Chem. 1985, 29, 417-424. 3. (b) Fernandez, A. L., Granda, M., Bermejo, J., Menendez, R., Carbon. 1999, 37, 1247-1255. 3. Dastan, A., Tahir, M. N., Ulku, D., Balci, M., Tetrahedron. 1999, 55, 12853-12864.

176

PO-45 A Regioselective Approach for Functionalization of Indolines/Indoles at the 5-Position

Haydar Kilic, Berrak Ertugrul, Farrokh Lafzi, Nurullah Saracoglu

Atatürk University, Faculty of Sciences, Department of Chemistry, 25240 Erzurum, TURKEY

C5-substituted indolines and indoles represent a structural motif commonly found in pharmaceutical drugs and natural products [1,2].Regioselective functionalization at the benzene ring of indole has limited reports [3,4]. Hence, we aimed to develop a suitable method to regioselective alkylated indolines and indoles at the C5-position. Michael reaction has a significant role in organic synthesis due to the tolerance for most functional groups, the mild reaction conditions, and their ability to build up complex molecular architectures. For this reason, Michael-type Friedel-Crafts alkylation of N-benzyl indolines with various Michael acceptors was investigated. Following oxidation of C5-substituted indolines afforded indoles containing alkyl group at 5-position.

Scheme 1.Synthesis of C5-Substitued Indoline/indoles

Authors are indebted to The Scientific and Technical Research Council of Turkey (TUBITAK, Grant No: 114Z200) for financial support of this work.

References

1. A. J., Kochanowska-Karamyan; M. T. Hamann, Chemical Reviews, 2010, 4489-4497. 2. Y. N. He; X. L. Li; J. Li; X. C. Li; L. Guo; L. Hai; Y. Wu; Tetrahedron Letters2014, 3938-3941. 3. L. Y. Jiao; M. Oestreich; Org. Lett.2013, 15, 5374-5377. 4. V. Lanke; K. R. Prabhu; Org. Lett.2013, 15, 6262-6265. 5. R. C. Simon; J. H. Sattler; J. E. Farnberger; C. S. Fuchs; N. Richter; F. Zepeck; W. Kroutil;Tetrahedron:

Asymmetry, 2014, 25, 284-288.

N

HN

OOF

FF

NH2O

OH

silodosin is C5-substituted indoline derivative5 ¨a1-adrenoceptor antagonist ¨drug for treatment of benign prostatic hyperplasia

NH

NBn

R

O2N

NBn

Ar

O2N

177

PO-46 PurificationandCharacterization of Glutathione S-transferaseFrom

LaurelFruit(Prunus Laurucerasus L.) ResearchTheEffectsof Some Metal Ions on Enzyme Activity

Fikret TÜRKANa, Neslihan BALCIb, Halis ŞAKİROĞLUb

aIgdırUniversity , Faculty of Engineering,Department of FoodEngineering, Karaağaç Kampüsü,TR-76100 Igdır,Turkey bAtatürkUniversity , Faculty of Science, Department of Biochemıstry,, TR-25240 Erzurum,Turkey

Abstract

The laurelfruit (Prunus Laurocerasus L.) is a plant, widely used in folk medicine and is well known for its antioxidant properties. In this study, Glutathione S-transferase (GST), one of well-knownantioxidantenzyme, waspurifiedfromthelaurelfruitflesh. Thepurification of the enzyme was performed separately by affinity and gel filtration chromatography. The purity of the enzyme was determined by SDS-PAGE electrophoresis. Characterization studies were done for the enzyme. For this purpose, optimal pH, optimal temperature, optimum ionicstrength, stable pH, KM and Vmaxvalues for GSH and CDNB were also determined for the enzyme as 7.0 in K-phosphate buffer, 30°C, 0.125 M, 6.5 in K-phosphate buffer, 0.344 mM, 0.89 mM, and 0.098 EU / ml, 0.214 EU / ml, respectively. Additionally, inhibitoryeffects of some metal ions Cd2+, Ni2+, Cu2+, Mg2+, and Ca2+wereexaminedtheenzyme’sactivity in vitrobyperformingLineweaver–Burk graphs and plotting activity %. IC50 and Ki values were calculated for each of metal ions.

References

1. S. Güvercin, M. Erat, H. Şakiroğlu, Protein &PeptideLetters,2008, 15, 6-12 2. E. Akkemik, P. Taser, A. Bayindir, H. Budak, M. Ciftci, EnvironmentalToxicology an 3. Pharmacology, 2012, 34, 888-894 4. Z. Chun-hua, W. Ze-ying, J. Ting, G. Ying, RiceScience, 2013, 20(3), 173-178

178

PO-47

Molecular Dynamics Studies of The Carboxy Indanone and Tetraline Compounds by NMR Spectroscopy

Cavit KAZAZa,, Süleyman GÖKSUa, Adem ERTÜRKb, Barış ANILa,Akın AKINCIOĞLUc

aDepartment of Chemistry,Faculty of Science, Atatürk University, TR-25240, Erzurum, Turkey bCentralResearch Laboratory, Atatürk University, TR-25240, Erzurum, Turkey

cCentral Researching Laboratory, Ağrı İbrahim Çeçen University, Ağrı, Turkey Abstract: NMR spectroscopy is not only a spectroscopic method of determining the chemical structure of the unknown compounds; at the same time, it is also a powerful tool for observing the dynamic processes that may be occurring within or between molecules: bond rotation about bond axes, ring inversion and tautomerism (intramolecular and intermolecular exchange of nuclei between functional groups)[1]. In the literatüre, an important number of publications was focused on tautomerism[2]. In this study, the tautomeric system of a few carboxy indanone and tetralone derivatives[3]has been investigated by NMR spectroscopy between 223 and 298 K. At room temperatures keto tautomer was the major isomer; however, at low temperatures two isomers were foundFig.1.

Figure 1.1H-NMR spectra of 4,5-Dimethoxy-1-oxo-indan-2-carboxylic acid methyl ester. *We are grateful to Atatürk University for supporting this work. References

1. M. Balcı, Basic 1H- and 13C-NMR Spectroscopy, 1st Edition,Elsevier Store, 2005, 430. 2. Guillermo M. Chans, E. Laura Moyano, María Teresa Baumgartner,Journal of Molecular Structure

1059, 2014, 176–184. 3. Y. Akbaba, A. Akıncıoğlu, H. Göçer, S. Göksu, İ. Gülçin, and C. T. Supuran,J Enzyme Inhib Med.

Chem,2014, 29(1), 35–42.

179

PO-48 Effect of Cu and Al Additive on the Functional Properties of Vanadium Oxide

Thin Films Grown by Spray Pyrolysis Method

Betül GÜZELDİR and Mustafa SAĞLAM

Department of Physics, Faculty of Science, Atatürk University, TR-25240, Erzurum, Turkey

Abstract: In this study, undoped and different rate Cu and Al doped vanadium oxide thin films were deposited on glass substrates by spray pyrolysis method. The influence of doping on structural, morphological and optic properties of thin films deposited by spray pyrolysis was investigated. Polycrystalline nature of the films was determined from the results of the XRD measurements. As the Cu and Al composition were increased, the decrease in structural irregularities and homogeneous growth to the whole surface were observed from the SEM and AFM measurements. On the other hand, the band gap values of undoped and doped samples have been investigated by means of the absorption measurements. It has been seen that, the band gap values of vanadium oxide thin films have been increased with increase Cu and Al rates.

180

PO-49 Interpretation of the Laterally Inhomogeneous FeCrNiC/n-GaAs Contacts by Tung’s

Approach

Bahattin ABAY Department of Physics,Faculty of Science, Atatürk University, TR-25240, Erzurum, Turkey, [email protected]

Abstract:

The current-voltage-temperature (I-V-T) characteristics of Schottky structure with a quadripartite alloy FeCrNiC on n-GaAs have been investigated in the temperature range of 24-400 K, for the first time. The apperent ideality factor ( ap.n ) and apparent barrier height ( ap.φ ) parameters have remained almost unaltered,

between 1.06 and 1.13 and at a value of about 0.810 eV at temperatures above 200 K, respectively. Accordingly, it can be supposed that FeCrNiC alloy contacts on n-GaAs have shown excellent Schottky diode behaviour due to the ideality factor values near the unity and almost independent of the sample temperature above 200 K. An abnormal decrease in the ap.φ and an increase in the ap.n with a decrease in temperature have

been observed below 200 K. This behaviour has been explained on the basis of the thermionic emission (TE) theory by incorporating the concept of inhomogeneous multiple barriers with nanometer-sized patches with low barrier height (BH) at the metal-semiconductor (MS) interface. The BH inhomogeneity assumption has also been interpreted by using the linear relationship between the ap.φ and ap.n parameters. The modified Richardson

plot, from Tung’s approach, yields a satisfactorily value for the Richardson constant; considering the effective patch area which is significantly lower than the entire geometric Schottky contact area, at the temperatures below 200 K. Thus, our results confirm that the use of Tung’s lateral inhomogeneity approach is more appropriate to construe the I-V-T characteristics of MS structures with inhomogeneous interface.

181

PO-50 Ascorbic Acid (Vitamin C): Important for Human Nutrition Physiology and Health, an

Antioxidative & Anticarcinogenic Vitamin

Bilgehan POLATOĞLU Department of Food Technology, Technical Vocational High School Hınıs, Atatürk University, TR-25600, Erzurum, Turkey

Abstract: Free radicals occur based on metabolic activities, malnutrition, usage of cigarette-alcohol-medicine, stress, ultra violet rays, pesticides, radiation, chemicals, environmental pollution etc. Free radicals cause to debilitation of immune system destroying somatic cells and stimulate the vital diseases because of this. Antioxidative vitamins which strengthen immune system (A, E, C) protect cells pacifying free radicals. Vitamin C [Ascorbic Acid (AA)] is provided commonly in nature (especially fruits and vegetables). Ascorbic acid is an agent that is strong reducer, water-soluble, cofactor of a lot of enzyme and a substance capable of undergoing degradation and participating in various metabolic reactions. Cannot be synthesized by humans, it should be taken regularly through food. Ascorbic acid is used in the treatment and prevention of scurvy, different types of cancer (breast, oral, lung, pancreas, stomach, larynx, oesophagus, cervical), mental diseases, AIDS, infertility, colds, anaemia, cataracts, tension, lipid metabolism disorder, atherosclerosis and coronary artery. Ascorbic acid has a role in formation of collagen and connective-bone tissue & transformation of dopamine to noradrenaline. It provides absorption of iron, recovery of burn-injury and the regulation of gene expression. Ascorbic acid strengthens teeth-bones structure and joints; prevents oxidation of LDL cholesterol and the formation of carcinogenic substances; raises HDL cholesterol levels; protects sperm and bronchial asthma; reduces effects of allergenic agents. All of these positive effects have adverse effects with reductions of plasma vitamin C levels (inadequate nutrition, smoking, CO, birth control pills, stress). As it is seen, it is clear how it has great importance in terms of human nutrition physiology and health. Both vitamin C-rich diet conscious and continuation of research for the determination of antioxidant capacity of food in terms of society health should be established.

References

1. B. Cemeroğlu, Publiser: Association of Food Technology in Turkey, 2009, 707. 2. B. Mazlum, Current Approaches in Psychiatry, 2012, 4 (4), 486-505. 3. B. Polatoğlu, A.V. Beşe, 10th Chemical Engineering Cong./Koç University,2012, 51-52. 4. E. Mindell, Prestij Publishing, 2009a, 480. 5. E. Mindell, Prestij Publishing, 2009b, 400. 6. G. Dadalı, B. Özbek, Int. Journal of Food Sciences and Nutrition, 2009, 60 (1), 21-31. 7. H. Keskin, Istanbul University Publishing, 1970, 1020. 8. M. Demirci, Onur Graphic, 2010, 291. 9. Ş. Gökpınar, T. Koray, E. Akçiçek, T. Göksan, Y. Durmaz, E.U. Journal of Fisheries & Aquatic

Sciences, 2006, 23 (1/1), 85-89.

182

PO-51 Investigation of the Inhibition Effect of Kiwifruit (Actinidia deliciosa) Juice on Human

Carbonic Anhydrase-II Metin Bülbül, Gözde İmdat

Dumlupınar University Faculty of Arts and Science Department of Biochemistry Kütahya/TURKEY Abstract:

Carbonic anhydrases (EC 4.2.1.1) are metalloenzymes including Zn(II) ion catalyze the conversion of CO2 to HCO3 and H+, and are

participated in many crucial physiological processes concerning with pH homeostasis, respiration, CO2 and ion transport, some biosynthetic reactions (gluconeogenesis, lipogenesis etc.), tumorigenicity and so on1. Sixteen different carbonic anhydrase isoenzymes were described in organismsuntil now. hCA I is major CA isoenzyme and hCA II is present in human eye. Glaucoma is a group of diseases characterized by gradual loss of visual field due to an elevation in intraocular pressure (IOP). Carbonic anhydrase inhibitors reduce intraocular pressure by lowering aqueous humor formation. So, carbonic anhydrase isoenzymes (hCA I and hCA II) are therapeutic targets for the treatment of glaucoma. Some synthetic carbonic anhydrase inhibitors, such as acetazolamide (AAZ), dorzolamide (DZA)and brinzolamide (BRZ), have been used for the treatment of glaucoma2. But they are many side effects, so the importances of natural carbonic anhydrase inhibitors have been increasing recently. Kiwi (Actinidia deliciosa) is one of the most commercialized fruits in the international market. The cultivation of kiwi is widespread throughout the world.Itis excellent sources of vitamins (A, C, and E), minerals (potassium), dietary fiber, and polyphenols. Kiwi has a number of biologically active molecules and some of them show antioxidant and antiprolifertive effects3. Also kiwi consumption has been shown to have beneficial effects on constipation, with several clinical studies demonstrating its efficacy by improving laxation in healthy individuals and in patients with irritable bowel syndrome with constipation4. In this study, human carbonic anhydrase isoenzyme (hCA II) was purified from erythrocytes and the inhibition effect of kiwifruit juice on the esterase activities of this isoenzyme was investigated in vitro. IC50 value of kiwifruit juice was calculated as 25.905 µM for hCA II. Esterase Ki value is 14.208 µM for hCA II, respectively.

References

1. J.Y.Winum, D.Vullo, A.Casini, J.L.Montero, A.Scozzafava, C.T.Supuran; J. Med. Chem. 2003, 46, 2197-2204.

2. M. Kaya, E. Başar, E. Çakır, E. Tunca, M. Bülbül; J. Enzym. Inhib. Med. Chem. 2012,27, 509-514. 3. L. D’Evoli, S. Moscatello, M. Lucarini, A. Aguzzi, P. Gabrielli, S. Proietti, A. Battistelli, F. Famiani, V.

Böhm, G. Lombardi-Boccia; J. Food Compos. Anal. 2015, 37, 25-29. 4. J. Ansell, C.A. Butts, G. Paturi, S.L. Eady, A.J. Wallace, D. Hedderley, R.B. Gearry;Nutr. Res.2015, 35,

401-408.

https://tr.wikipedia.org/w/index.php?title=Actinidia_deliciosa&action=edit&redlink=1

183

PO-52 Synthesis and characterization of novel pyrazole, thiazole, thiadiazole and oxadiazole

derivatives of 1-(3-nitrophenyl)-3-phenyl-1H-pyrazole-4-carbaldehyde Samet MERT, Rahmi KASIMOGULLARI

Department of Chemistry,Faculty of Art and Science, Dumlupinar University, TR-43100, Kütahya, Turkey [email protected]

Abstract: Pyrazole derivatives have received great attention due to widespread applications in pharmaceutical and agrochemical industries [1]. Also pyrazoles are widely used as core motifs for development of novel therapeutics for inflammation and cancer [2]. In this study we aimed to synthesis novel heterocycles containing the pyrazole ring. For this purpose our starting compound 1-(3-nitrophenyl)-3-phenyl-1H-pyrazole-4-carbaldehyde was synthesized under the Vilsmeier-Haack reaction conditions [3]. Then cyclization reactions were performed and novel pyrazole, thiazole, thiadiazole and oxadiazole containing heterocycles were synthesized. The structures of the synthesized compounds were confirmed by using FT-IR, 1H NMR, 13C NMR and MASS spectroscopic methods.

NN

O

HPh

NO2

N

N

Ph

NN

O

CH3

ONO2

HO

N

N

Ph

NN Ph

Ph NO2

N

N

Ph

NNH

S

N

Ph

NO2

N

N

Ph

NN

S

CH3

O

N

H

H3C

O

NO2 *This study is supported by a grant (Project Number: 2015-30) from Dumlupinar University Research Fund.

References

1. P. Machado et al., Ultrason Sonochem, 2011, 18, 293. 2. R. Kasimogullari et al., Monatsch Chem, 2015, DOI: 10.1007/s00706-015-1450-7. 3. P.K. Sharma et al., Eur J Med Chem, 2011, 46, 1425.


184

PO-53 Determination of Fatty Acid and Heavy Metal Amounts in The Muscle of A Freshwater

Fish (Capoeta antalyensis) Using Gas Chromatography andAtomic Absorption Spectroscopy

Kazım UYSAL1*, Banu YALIM2, Yılmaz EMRE2,3, Özgür AKTAŞ2, Gül Nihan ÖZTÜRK1

1Dumlupınar University, Faculty of Arts and Sciences, Department of Biology, 43100, Kütahya, Turkey.

2Akdeniz University, Faculty of Sciences, Department of Biology, 07058-Campus, Antalya, Turkey. 3The Mediterranean Fisheries Research, Production and Training Institute, Kepez, Antalya, Turkey.

[email protected]

Abstract:

The main health role of fish for human depends on the fatty acid composition of fish (1, 2). But high heavy metal accumulation levels in fish may also cause serious health problems for human. In this study, fatty acid composition and heavy metal accumulation ratios of Capoeta antalyensiswere investigated using gaschromatography andatomic absorption spectroscopy. The ratios of saturated fatty acids and unsaturated fatty acids in the muscle of C. antalyensis were found 1.09 and 2.24 g/100g wet weight, respectively. The amounts (g/100gwet weight) of total ω3polyunsaturated fatty acids and ω6 polyunsaturated fatty acids in the muscle of C. antalyensis were found as 0.70 and 0.18, respectively. Dominant polyunsaturated fatty acids were linoleic(C18:2ω6), linolenic (C18:3ω3), eicosapentaenoic (C20:5ω3) and docosahexaenoic (C22:6ω3) acids. In this study, the amounts of arsenic (As), copper (Cu), zinc (Zn), magnesium (Mg), iron (Fe), lead (Pb), cadmium (Cd) and mercury (Hg) in the muscle of C. antalyensiswere also examined. The accumulation amounts of As, Cu, Zn, Mg and Fe decreased with increasing fish length. However the accumulation amounts of Pb, Hg and Cd rising with increasing fish length. The amounts of all analyzed heavy metals in the edible portions of C. antalyensis were also less than acceptable levels of Turkish Standards Institute (TSE), Food and Agriculture Organization (FAO) and World Health Organization (WHO). References

1. Uysal K., et all., Chemistry of Natural Compounds, Vol. 46, No. 6 (2011).

2. Kris-Etherton P.M. et all., Journal of the American Heart Association, 106:2747-2757 (2002).

3. Handy, R.D., Comp. Biochem. Physiol., 107C-84C (1994).

185

PO-54 Synthesis and Characterization of ZnO Nanostructures via Tartaric Acid Gel Method

Mustafa Tuncera, Seher Cetina, Hasan Gocmeza

aDepartment of Material Science and Engineering,Faculty of Engineering, Dumlupınar University, Kutahya,

Turkey Abstract: Nanostructured zinc oxide powders were synthesized by tartaric acid gel method. The zinc nitrate and tartaric acid mixed aqueous solutions were used as starting precursor. The precursors gelled from solutions at different pH were prepared and then calcined from 600 to 1000°C. Surface area measurement (BET), X-ray diffraction (XRD), scanning electron microscopy (SEM) and thermal methods (DTA-TG) were used to characterize the synthesized powders. ZnO powders were also used as thin film photoanode for DSSC application. This study is supported by a grant (Project Number: 2015-11) from Scientific Research Projects Committee of Dumlupınar University.

186

PO-55 Purification and Characterization of Glutathione S-transferase FromLaurel Fruit (Prunus

Laurucerasus L.) Research The Effects of Some Metal Ions on Enzyme Activity Fikret TÜRKANa, Neslihan BALCIb, Halis ŞAKİROĞLUb

aIgdır University , Faculty of Engineering,Department of Food Engineering, Karaağaç

Kampüsü,TR-76100 Igdır,Turkey bAtatürk University , Faculty of Science, Department of Biochemıstry, , TR-25240

Erzurum,Turkey Abstract The laurel fruit (Prunus Laurocerasus L.) is a plant, widely used in folk medicine and is well known for its antioxidant properties. In this study, Glutathione S-transferase (GST), one of well-known antioxidant enzyme, was purified from the laurel fruit flesh. The purification of the enzyme was performed separately by affinity and gel filtration chromatography. The purity of the enzyme was determined by SDS-PAGE electrophoresis. Characterization studies were done for the enzyme. For this purpose, optimal pH, optimal temperature, optimum ionic strength, stable pH, KM and Vmax values for GSH and CDNB were also determined for the enzyme as 7.0 in K-phosphate buffer, 30°C, 0.125 M, 6.5 in K-phosphate buffer, 0.344 mM, 0.89 mM, and 0.098 EU / ml, 0.214 EU / ml, respectively. Additionally, inhibitory effects of some metal ions Cd2+, Ni2+, Cu2+, Mg2+, and Ca2+ were examined the enzyme’s activity in vitro by performing Lineweaver–Burk graphs and plotting activity %. IC50 and Ki values were calculated for each of metal ions. References

1. S. Güvercin, M. Erat, H. Şakiroğlu, Protein & Peptide Letters, 2008, 15, 6-12 2. E. Akkemik, P. Taser, A. Bayindir, H. Budak, M. Ciftci, Environmental Toxicology an

Pharmacology, 2012, 34, 888-894 3. Z. Chun-hua, W. Ze-ying, J. Ting, G. Ying, Rice Science, 2013, 20(3), 173-178

187

PO-56 Synthesis of Some Benzamide Derivatives and Investigation of Their Crystal Structures

Şükriye ÇAKMAKa, Halil KÜTÜKb

, Mustafa ODABAŞOĞLUc

aSinop University, Environmental Health Program, TR-57000, Sinop, Turkey bDepartment of Chemistry, Faculty of Art and Science, Ondokuz Mayıs University, TR-55139, Samsun,Turkey

cPamukkale University, Department of Chemistry and Chemical Processing Technologies, TR-20070, Turkey

Abstract: Amides are vital structures which falls within the formula of many natural products (e.g. proteins and

peptides), and also very important drug molecules.1 These compounds have been widely studied for their biological and therapeutic activities: antitumor, antimicrobial, antibacterial, antifungal, anti-HSV, analgesic,

anti-inflammatory, anticancer.2 One of the other areas that amide compounds are also broadly used is in

medical and industrial sectors such as plastic, rubber industry, paper industry and agricultural areas.3

In this study, a series of substitute benzamide derivatives were synthesized (Scheme 1).

Scheme 1. Synthesis of Benzamide derivatives (1-6) The structures of these compounds were established by IR, 1H- NMR and 13C -NMR spectroscopy and elemental analysis techniques. The molecular structures of synthesized compounds have been also determinated by X-ray diffraction method (Scheme 2).

Scheme 2. a) An ORTEP view of compound (2), with the atom-numbering scheme and 40%probability displacement ellipsoids. b) A packing diagram of (2) with the C-H… intermolecular interactions shown as dashed lines. References

3. N. Kanışkan, Ş. Kökten and İ. Çelik, ARKIVOC viii, 2012, 198. 4. N. Kushwaha, R K. Saini and S K S. Kushwaha, Int. J. Chem. Tech. Res.,2011, 3, 203. 5. Y. Liu, G Y. Zhang, Y. Li, Y N. Zhang, S Z. Zheng, Z X. Zhou, S J. An and Y H. Jin,

Heteroat. Chem.,2013, 24, 9.

188

PO-57 Synthesis of Some Pyrimidine Derivatives and Investigation of Their Molecular

Structures and Spectroscopic Properties Şükriye ÇAKMAK

a, Halil KÜTÜKb, Mustafa ODABAŞOĞLU

c

aSinop University, Environmental Health Program, TR-57000, Sinop, Turkey bDepartment of Chemistry, Faculty of Art and Science, Ondokuz Mayıs University, TR-55139, Samsun,Turkey

cPamukkale University, Department of Chemistry and Chemical Processing Technologies, TR-20070, Turkey

Abstract: Pyrimidines are found in a broad range of natural products and are contained in numerous pharmaceutically important molecules and functional materials.1 Pyrimidines and their derivatives are important for drugs and

agricultural chemicals.1 Many pyrimidine derivatives are used for thyroid drugs and leukemia.2 They are also reported to possess antimicrobial, antitumor, antifungal and anticonvulsant activities. Natural and unnatural polymers also contain pyrimidine derivatives.3 Pyrimidine synthesis study consists of two steps: The first step was the synthesis of substitutesecondary amide compounds (1). The second step, secondary amide compounds wereconverted in one step into the corresponding pyrimidines (2) (Scheme1).

Scheme 1. The synthesis steps of pyrimidine derivatives. References

1. M. Movassaghi, D H. Matthew, Nature Protocols, 2007, 2(8), 2018-2023. 2. T A. Naik and K H. Chikhalia, ,E-Journal of Chem.,2007, 4, 60-66. 3. D H. Matthew and M. Movassaghi, Chem. Eur.J,2008, 14, 6836-6844.

189

PO-58 Solid Phase Extraction of Tartrazine and Determination by UV-Vis Spectrophotometer

Aslıhan KARATEPEa, Nazan SAYARa

aDepartment of Chemistry,Faculty of Art and Science,Nevşehir Hacı Bektaş Veli University, TR-50300, Nevşehir, Türkiye ([email protected])

Abstract:

Food additives are commonly used in processed food stuffs to improve appearance, flavor, taste, color, texture, nutritive value and conservation. Food dyes are one of the most widely used additives incommercial products such as candies, beverages, dessert powdersas well as pharmaceuticals and cosmetics. However, some syntheticcolorants can be pathogenic, particularly if theyare excessively consumed. Because of this, lawsand regulations strictly control the use of additivesynthetic colorants in foods. Consequently, theanalysis of the synthetic colorants in foods is veryimportant. Tartrazine is one of the best known and and most commonlyused synthetic food dyes and this work was aimed to develop a new,simple and accurateseparation, preconcentration, and spectrophotometricdetermination of tartrazine (E 102). The method was based on solid phase extraction by using Sepabeads SP-207 resin. Analytical parameters such as HCl concentration, eluent type, sample volume, flow rates of solutions and matrix effects were examined for the quantitative recoveries of tartrazine. 10 mL of 0.05 M HCl in ethanol was used to eluate the retained dye. The recoveries were found as >95%. The method was applied to various food samples successfully.

References

1- S. P. Alves, D. M. Brum, E. C. B. Andrade, A. D. P. Netto, Food Chemistry, 2008, 107, 489–496. 2- S. Sayar, Y. Ozdemir, Tr. J. Of Chemistry, 1997, 21, 182-187. 3- E. Dinc¸ E. Baydan, M. Kanbur, F. Onur, Talanta,2002, 58, 579-/594.

190

PO-59 Design, Synthesis and Anticancer Activity of Novel Acylthioureas with Pyrimidine Core*

İrfan KOCAa, Muhammet ERa, Mehmet GÜMÜŞa, Aykut ÖZGÜRb, Yusuf TUTARc aDepartment of Chemistry, Bozok University, Yozgat, Turkey

bDepartment of Bioengineering, Gaziosmanpaşa University, Tokat, Turkey cDepartment of Biochemistry, Cumhuriyet University, Sivas, Turkey

e-mail : [email protected] Abstract: Pyrimidine that a heterocyclic compound is located in the structure of many biologically active substances. These compounds have attracted the attention of synthetic organic chemists for years because they have a variety of biological activities[1]. Intensive investigations about thiourea groups used successfully in the synthesis of biologically active compounds are being conducted in recent years. Thiourea derivative compounds used as certain derivatives are commercially fungicide, insecticide, herbicide and showing antimalarial, antihypertensive, antimicrobial, anti-HIV, anticancer property are available [2].

Scheme1.The synthesis of pyrimidinyl acyl thioureas.

We define the synthesis of novel acyl thioureas derivatives bearing pyrimidine moiety (Scheme 1).All the structures of newly synthesized compounds were elucidated and were characterized using their elemental analysis, FT-IR and 1H and 13C NMR.Anticancer activities of synthesized pyrimidinyl acyl thioureas derivatives were evaluated on human invasive ductal breast and human bone osteosarcoma cell lines by XTT cell proliferation assay. Cell culture studies demonstrated that compounds displayed significant toxicity on the cell lines, and the levels of toxicity altered in the presence of various side groups. Molecular docking study of compounds was performed on ATPase domain of human heat shock protein 90 alpha isoform. These in-vitro and in-silico results confirmed that novel pyrimidinyl acyl thioureas derived compounds have significant potential for breast and bone cancer treatment.

*This study is supported by a grant (Project Number: 2014FBE / T127) from Scientific Research Projects Unit of Bozok University.

References

1. T.P. Selvam, C.R. James, P.V. Dniandev, S.K.Valzita, Research in Pharmacy. 2012, 2, 01- 09. 2. A. Saeed, U. Flörke, M.F. Erbenc, J. Sulfur Chem..2014, 35, 318 - 355.

191

PO-59 Efficient Synthesis of Potential Biactive Molecules: Pyrazole, Thiazole and Coumarine Hybrid

Compounds* Mehmet GÜMÜŞa, İrfan KOCAa, Ali DİŞLİb

aBozok University, Faculty of Arts and Sciences, Department of Chemistry, Yozgat, Turkey bGazi University, Faculty of Sciences,Department of Chemistry,Ankara,Turkey

e-mail : [email protected] Abstract: Coumarines (2H-1-benzopyran-2-ones) are classified as member of the benzopyrone family of compounds which possess a wide spectrum of biological activity as anticancer, antimicrobial, anti-inflammatory, and analgesic agent. Coumarine derivative antibiotics have been used for the treatment of infection diseases for several years [1]. Thiazole and its derivatives were evaluated in drug design for the treatment of bacterial and fungal infections, tuberculosis, allergies, HIV infections, neurodegenerative diseases and recently for the treatment of cancer [2]. The studies on the pyrazoles started with the discovery of antipyretic effects of these compounds. Since then, this and other biological properties of pyrazole derivatives such as anticancer, antitubercular, antidiabetic, antiviral, antihypertensive, antidepressant and antimicrobial activitye.t.c. have been reported. Several pyrazoles have been commercialized such as the blockbuster drugs Celecoxib and Rimonabant [3].

Scheme1.Synthesis of new hybrid compounds.

In view of these, we wish to report a facile method for preparation of new compounds bearing poly heterocyclic moiety such as pyrazole, thiazole and coumarine moiety from the chalcone. The characterization of the new compounds is based on their IR (ATR), 1H NMR, 13C NMR and elemental analyses.

*This study was financially supported by the Scientific Research Projects Unit of Bozok University.

References

M. W. Amolins and B. S. Blagg, Mini Rev. Med. Chem., 2009, 9, 140-152. N. A. A. El-Kanzi, J, Appl. Chem., 2012, 2, 71-77. S. G. Kucukguzel, S. Senkardes, Eur. J. Med. Chem., 2014 , in press.

192

PO-61 Synthesis, Characterization and Adsorption Studies of Cationic Dye Adsorbent

Masoomeh MEHRNIA, Oya BAL, Murat TORUN, Dilek ŞOLPAN Department of Chemistry,Hacettepe University, TR-06800, Ankara, Turkey

[email protected] Abstract: Among the processes applied to the treatment of wastewater of textile industry, adsorption has the advantage to be efficient and economically feasible. Hydrogels have been paid great attention in the research on adsorption for removal of dyes. The aims of this study were to prepare the system of acrylamid-based hydrogel by adding aconitic acid (ACA) monomer to incerease the adsorption capacity of cationic dyes, mechanical stability and change hydrophobic or hydrophilic properties. Charged groups connected to the network structure have very important effect on swelling and adsorption properties of hydrogels so pH-sensitive copolymers can be prepared by using triprotic and ionic monomer such as aconitic acid. Hydrogel based on acrylamide and aconitic acid was synthesized and crosslinked by gamma radiation at an absorbed dose of 25 kGy. Hydrogels were prepared in different ratios. First hydrojel includes 96% AAm and 4% ACA , was called P(AAm/ACA)I.

Second hydrogel includes 83% AAm and 17% ACA , was called P(AAm/ACA)II. In this study, 60Co–gamma

source was used for hydrogels synthesis. Hydrogels were analysed to explain interaction between monomers by using spectroscopic methods. Swelling properties of the hydrogel in water at pH 3,5,7,8 ,in methylene blue and safranine-o solutions at pH 7 were investigated. The amount of dye adsorbed per unit mass of hydrogel was determined.The results showed that the swelling rate of the hydrogel depends on the pH and the ionic nature of the dye. The maximum % swelling was observed in distilled water at pH 8 because of the repulsion forces between the hydroxyl ions and carboxylic acid groups of hydrogels. The swelling rate in water dye solutions are nearly the same as in distilled water at pH 7. Swelling of hydrogels in methylene blue solution is lower than in safranine-o solution. The type of adsorption isotherm was ‘’S type’’. The hydrogels were obtained in this study

can be used as adsorbent for methylene blue and safranine-o dyes. High cationic dye adsorption in the literature was obtained. Dye adsorption increases by increasing the initial concentration of dye solutions and ACA content in hydrogels. References

1. I.Spirevska, L.Soptrajanova, R.Gulaboski; Analytical letters, 2000, 33(5), 919-928. 2. S.Spoljaric, R.A.Shanks; Express Polymer Letters, 2012, 6(5), 354–372. 3. M.Saska, N.G.Zapata; International Sugar Journal, 2006, 108(1288), 203-209.


193

PO-62 Optimum ConditionsforChromatographicSeperation of N-

NitrosodiphenylaminefromItsIntermediates SinemDEMIR, Murat TORUN, Dilek ŞOLPAN

Department of Chemistry, Hacettepe University,06800, Beytepe/Ankara - Turkey [email protected]

Abstract: Nitrosamines can be found in waste waters anddrinkingwaterbecause ofindustrialapplications as well as duringdisinfection of supplywater. Most of the nitrosamines were detected in water which are carcinogenic. N-Nitrosodiphenylamine(NDPhA) is selected as model compound in this study andits chromatographic separation from its intermediates after recovery from water wasexamined. Solid phase extraction (SPE) is a method of sample preparation that concentrates and purifies analytes from solution by sorption onto a disposable solid phase cartridge, followed by elution of the analyte with a solvent appropriate for instrumental analysis.In this study,the concentration process for aqueous solutions of NDPhAand the experimental conditionssuch as determination ofexperimentalparametersandreproducibilityafter SPE werestudied. Therecovery of NDPhA were followedbyusing Dionex ICS 3000 system after SPE process by ThermoDionex AT280 with Thermo Scientific Solex C18 cartridge (500 mg).Low concentration solutions of NDPhA were prepared and used fortheauto-concentrator system which are carriedout at different NDPhA concentrations in water, varying from 0.01 to 2 mg/L. To increase the yield of NDPhAextractioninto the organic solvent, Carboxen 572 (Supelco, 20/45 mesh size), Alumina (BDH, for chromatographic adsorption analysis), Alumina (BDH, calcined) and Active Coal (Fluka, from peat, multi-purpose, steam activated and acid washed, powder) were usedandused as filling materials. In this system, the aim was to determine the optimum experimental conditions, including filling material, volume of solvents, number of solvents, volume of the analyzed solution. Dichloromethane,hexane, methyl alcohol were selected as solvents. NDPhA was eluted with methyl alcohol and analyzed by Dionex IC 3000 HPLC. The results are shown that the recovery yield was up to %97. Using C18 cartridge was found to be more efficent method to seperate NDPhA from aqueous solution. *Thisstudy is supportedby a Project Number: 112T822from TUBİTAK

References: 1. J.Nawrocki, P.Andrzejewski;Journal of HazardousMaterials. 2011, 189, 1-18. 2. P.Andrzejewski, B.Kasprzyk-Hordern, J.Nawrocki;WaterResearch. 2008, 42, 863-870. 3. Y.Y.Zhao, J.M.Boyd, M.Woodbeck, R.C.Andrews, F.Quin,S.E.Hrudey, X.F.Li;Environ. 4. Sci. Technol.2001, 42, 4857-4862.


194

PO-63 Synthesis and Antimicrobial Evaluationof

New 3-Alkyl(Aryl)-4-[3-ethoxy-2-(4-methoxybenzoxy)-benzylidenamino]-4,5-dihidro-1H-1,2,4-triazol-5-ones*

Faruk KARDAŞa, Haydar YÜKSEKb, Özlem GÜRSOY-KOLb, Önder ALBAYRAKc, Muzaffer ALKANc

aErzincan University, Education Faculty, 36100 Erzincan – Turkey bKafkas University, Department of Chemistry, 36100 Kars – Turkey

cKafkas University, Education Faculty, 36100 Kars – Turkey

Abstract: 1,2,4-triazole and 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives are reported to possess a broad spectrum of biological activities such as antimicrobial, antitumor and anti-HIV properties [1-3].

In this study, nine new 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives were synthesized from the reactions of 3-ethoxy-2-(4-methoxybenzoxy)-benzaldehyde (2) with 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) and characterized by IR, 1H NMR, 13C NMR and UV spectral data. Then, antibacterial properties of 3-alkyl(aryl)-4-[3-ethoxy-2-(4-methoxybenzoxy)-benzilidenamino]-4,5-dihidro-1H-1,2,4-triazol-5-ones (3)by using Agar hole methods of against B. subtilis, Y.enterocolitca, B. cereus, S. aureus, E. coli, P. multocida and K. Pneumoniae strains and data were recorded.

OC2H5

CHO

OH + CCl

O

OCH3

Et3N-HCl

OC2H5

CHO

O C

O

OCH3+

OC2H5

O C

O

CH

N

NHN

N

O

OCH3

R

AcOH

-H2O

2 31

NHN

N

NH2

R O

Figure 1.Synthesis route of compounds 2, 3 * This study is supported by a grant (Project Number: 2011-FEF-31) from Scientific Research Projects Coordination Unitof Kafkas University.

References

1. N. Demirbas, R. Ugurluoglu, A. Demirbas, Bioorgan. Med. Chem.2002, 10, 3717-3723. 2. Z. Y. Li, Y. Cao, P. Zhan, C. Pannecouque, J. Balzarini, E. De Clercq, X.Y. Liu, Lett. Drug Des.

Discov.2013, 10, 27-34. 3. Ö. Aktaş-Yokuş, H. Yüksek, Ö. Gürsoy-Kol, Ş. Alpay-Karaoğlu, Med. Chem. Res.2015, DOI:

10.1007/s00044-015-1334-8.

195

PO-64 Contents and Distributions of Iron Fractions ın Bafra, Çarşamba and Suluova Soils and

Relationships with Some Soil Properties

Havva Sera ŞENDEMİRCİa, Güney AKINOĞLUb,Ahmet KORKMAZb, Ayhan HORUZb, Abdulkadir Sürücüc

aSoil, Fertilizer and Water Resources Central Research Institute, AnkaraTurkey bDepartmant of Soil Science and Plant Nutrition, Faculty of Agriculture, Ondokuz Mayıs University, SamsunTurkey

cDepartmant of Soil Science and Plant Nutrition, Faculty of Agriculture, Bingöl University, BingölTurkey

E-mail: [email protected] Abstract:

The aim of this study was to determine contents and distributions of iron fractions in Bafra, Çarşamba and

Suluova soils and relationships with some soil properties. For this aim, 26 soil samples were taken from 0-20 cm depth of agricultural fields of Bafra, Çarşamba and Suluova districts. Beside some physical and chemical

soil properties, exchangeable iron (Exch-Fe), organic bounded iron (OM-Fe), manganese oxides bounded iron (MnOX-Fe), amorph iron oxides bounded iron (AFeOX-Fe), crystal iron oxides bounded iron (CFeOX-Fe) and residual iron (R-Fe) contents of soils were determined. According to mean iron fraction values, iron fractions ordered as follows; R-Fe>CFeOX-Fe>AFeOX-Fe>MnOX-Fe>Exch-Fe>OM-Fe. Manganese oxides bounded iron form had significant negative correlations with soil pH (r=0,448*), total lime (r=-0,556**) and active lime (r=-0,448*) contents. There was a significant positive relationship (r=0,674**) between MnOX-Fe and available Mn contents of soils. While sand contents of soils gave significant negative correlations with CFeOX-Fe (r= -0.382*) and total iron contents (r=-0,467*), clay contents of soils had a significant positive correlation with total iron content (r=0,386*). In another word, total iron contents of soils increased with increasing clay contents in soils. It has been determined that sum of exchangeable + organic + manganese oxides bounded iron is diagonistic (effective) on the extractable iron by 0.005 M DTPA + 0.01 M CaCl2 + 0.1 M TEA (pH=7.3). The extractable iron content by 0.005 M DTPA + 0.01 M CaCl2 + 0.1 M TEA (pH=7.3) increased with increasing sum of exchangeable + organic + manganese oxides bounded iron of soils. Key Words: Exchangeable, organic bounded, manganese oxides bounded, amorph iron oxides bounded, crystal iron oxides bounded iron, residual iron, sequestration method. References: 1) Kryc, K. A, Murray R. W. and Murray, D. W., 2003. Elemental Fractionation of Si, Al, Ti, Fe, Ca, Mn, P,

and Ba in Five Marine Sedimentary Reference Materials Results from Sequential Extractions. Anal. Chim. Acta. 487, 117 – 128.

196

PO-65 Synthesis of Bromo Substituted Indenoquinoline-Amin Derivetives

Makbule EKİZa,b, Ahmet TUTARb, Yadigar ADİLOĞLUb

aDepartment of Chemistry,Faculty of Art and Science, Düzce University, TR-81620, Düzce, Turkey

bDepartment of Chemistry, Faculty of Art and Science,Sakarya University, TR-54187, Sakarya, Turkey [email protected]

Abstract: Tacrine was the first acetylcholinesterase (AChE) inhibitor to be launched as an Alzheimer’s disease (AD) drug but, together with evidences of beneficial effects on the AD symptoms, it showed several adverse side effects which in some cases made its use problematic. Also for this reason, many other AChE inhibitors were studied and research effort still continue aimed at improving the pharmacological profile of the prototypes. To fill the gap of brominated tacrine analogues, we realized the synthesis of brominated-indenoquinolineamin.

Scheme1.Synthesized brominated- İndenoquinolineamin Compounds *This study is supported by a grant (Project Number 2014-02-04-008 and 2014-50-02-025) from Scientific Research Projects

Committeeof Sakarya University.

References

1. X.M. Cheng, Ann. Rep. Med. Chem., 1994, 29, 331. 2. R. Diaz Brinton, R. S. Yamazaki, Pharm. Res. 1998, 15, 386. 3. A. Rampa, A. Bisi, F. Belluti, S. Gobbi, P. Valenti, V. Andrisano, V. Cavrini, M. Recanatini, Bio. and

Med. Chem., 2000, 8, 497-506.

No R1 R2 R3 R4 R5

1 H H Br H H

2 H H H Br H

3 H H H H Br

4 Br H Br H H

5 Br H H Br H

6 Br H H H Br

7 Br Br Br H H

8 Br Br H Br H

9 Br Br H H Br

197

PO-66 Improved Synthesis and Naked-Eye Ag+ ChemosensingProperties of 2,9-Dichloro-1,10-

Phenanthroline* Said Nadeem a,b, Mehmet Ali Özlera, Muhammad Raza Shah c

aDepartment of Chemistry, Faculty of Sciences, Muğla Sitki Koçman University, Kötekli-48000, Muğla, Turkey bDepartment of Medicinal and Aromatic Plants, Koyceyiz Vocational School, Mugla University, Mugla, Turkey

cInternational Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan

Abstract: We have successfully developed a “turn-on” naked-eye chemosensor for Ag+ based on 2,9-dichloro-1,10-phenanthroline. Phen-Cl25 was obtained from dione 4 with good yield and less side productsin SOCl2 compared to the literature solvent POCl3. Novel compound N-monodealkylated 9-chloro-1-(3-chloropropyl)-1,10-phenanthrolin-2(1H)-one 6 was obtained when reaction was performed inSOCl2 for 8 h, but increasing reaction time to 16 h resulted full N-dealkylation. Naked-eye andspectroscopic Ag+ selective recognition was observed when 5 was mixed with nitrates of Co2+,Cr3+, Cu2+, Mn2+, Ni2+, Ag+, Fe3+, and Zn2+. Addition of 5 into a colorless solution of Ag+ resulteda light yellow color. Chemosensor successfully detected Ag+ at concentration range 15–

210 M byUV-visible spectroscopy.

Figure1Naked-eye chemosensing of Ag+Figure 2UV-visible spectrum of Ag+ chemosensor in the presence of various metals

*This study was supported by TÜBİTAK-BİDEB 2216 and performed at the International Center for Chemical and Biological Sciences, University of Karachi and Muğla Sıtkı Koçman University Turkey.

References

1. S. Nadeem, M. R. Shah, Sensor Letters, 2015, 13, 376-380.

198

PO-67 Antioxidant and Cytotoxic Activity of Ganoderma resinaceum Boud.

Mehmet Emin DURUa, Selçuk KÜÇÜKAYDINa, Aziz TÜRKOĞLUb, Gülsen TELa, Mehmet ÖZTÜRKa. aMuğla Sıtkı Koçman University, Faculty of Science, Department of Chemistry48121 Kötekli Muğla, Türkiye

bMuğla Sıtkı Koçman University, Faculty of Science, Department of Biology 48121 Kötekli Muğla, Türkiye

Abstract: Mushrooms are considered, all over the world, valuable health foods since they are poor in calories, fat and essential fatty acids, and rich in proteins vitamin and minerals [1-3].In previous studies various biologic activities such as antioxidant, antibacterial, antifungal, immunomodulatory, antiviral, anti-inflammatory, cytotoxic, antiaromatase, and anticholesterole activities of mushrooms investigated. In this study, antioxidant and cytotoxic activity of Ganoderma resinaceum analyzed.G. resinaceum is a basidiomycete fungus belonging to the order Polyporales and the family Ganodermataceae.G. resinaceum was collected in January 2015 from Fethiye(Muğla), in the South-western part of Turkey. Dried mushroom samples was extracted by hexane, methanol and distilled water respectively.Antioxidant activities of the extracts were determined by using the methods: β-Carotene linoleic acid bleaching assay, DPPH radical scavenging activity, ABTS cation radical scavenging activity, CUPRAC (Cupric ion reducing antioxidant capacity) and metal chelating activity method.The cytotoxic activity screening of the extract was performed using MCF-7 (breast), human tumor cell lines.In DPPH radical scavenging, ABTS•+ scavenging and and β-carotene linoleic acid bleaching assay the methanol extract of G. resinaceum showed the best activity 74,78±0,81%, 91,91±0,22% and 91,15±0,15% at 400 μg/mL concentration, respectively while in CUPRAC assay and metal chelating activity, the water extract of this mushroom exhibited higher activity.In Cytotoxicity assay, extracts of G. resinaceum (hexane, methanol and water) showed inhibition, %61,57, %54,31 and %35,7 at 50 μg/mL concentration respectively. *This study is supported by a grant (114Z550) from The Scientific and Technological Research Council of Turkey (TÜBİTAK).

References

1. A. Türkoğlu, M.E. Duru, N. Mercan, İ. Kıvrak, K. Gezer, Food Chem. 101, (2007), 267–273. 2. G. Tel, M. Apaydın, M.E. Duru, M. Öztürk, Food Anal. Method, 5, (2012), 495–504. 3. K. Gezer, M.E. Duru, I. Kıvrak, A. Türkoğlu, N. Mercan, H. Türkoğlu, S. Gülcan, African J.

Biotechnol. 5, (2006), 1924–1928.

199

PO-68 Fumigant Toxicity of Essential Oil of Coridathymus capitatus Against Adults of the Lesser

Grain Borer, Rhizopertha dominica (Coleoptera: Bostrichidae)Fabricius.

Selçuk KÜÇÜKAYDINa, Mehmet Emin DURUa, Memiş KESDEK b, Gülsen TELa, Mehmet ÖZTÜRKa. aMuğla Sıtkı Koçman University, Faculty of Science, Department of Chemistry48121 Kötekli, Muğla, Türkiye

bMuğla Sıtkı Koçman University, Fethiye Ali SıtkıMefharet Kocman Vocational School, Department of Environment Protection and Technologies48300 Fethiye, Muğla

Abstract:

Wheat, which has an important role for human and animal nutrition, is first in terms of cultivation and production in the world. Wheat, due to raw material of bread and the basic ingredients of various food products, is superior compared to other cereals.Storage conditions are significantly effective on the quality of the wheat. The lesser grain borer, Rhizopertha dominica (Coleoptera: Bostrichidae), is one of the most risky and harmful pest of stored grains in many countries and, distributes all over the World. This pest can cause significant damage to harvested grains and may drastically decrease yields, also directly affects both quantity and quality of stored grains. Essential oils are presently regarded as a new class of ecological products for controlling insect pests, and they are among the best-known substances tested against insects. Essential oils are potential sources of alternative compounds to the currently used fumigants, because of their low toxicity to warm-blooded animals, high volatility, and toxicity to stored grain insect pests. In this study, fumigant toxicities of essential oil obtained from Coridathymus capitatus (Labiatae) were evaluated against the adults of important stored grain pest, lesser grain borer, Rhizopertha dominica in thePetri dishes. After exposure, mortality of the adults was determined at 24th, 48th and 96th hours. The results showed that essential oil of C. capitatus has an important insecticidal effect on adults of Rhizopertha dominica in comparison with controls. The insecticidal effect was influenced by the concentrations of the essential oil and the exposure time. Experiments showed increased mortality rate as a result of the increase in concentration. The most mortality rates were found after 48 h of treatment with the different concentrations as %58,5 (10 µl), %80,6 (20 µl) and %97 (30 µl). Considering on all these results, essential oil of C. Capitatus may be used as potential natural and non-toxic insecticidal agent against adults of Rhizopertha dominica.

References

1. Ahmet, H., Adak, M.S., 2007. Irak’ta yetiştirilen bazı ekmeklik buğday çeşitlerinde kallus oluşumu ve

bitki rejenerasyonu, Tarım Bilimleri Dergisi, 13 (3): 285-292. 2. Demirbaş, H.Y., Dursun, İ. 2007. Buğday tanelerinin bazı fiziksel özelliklerinin görüntü işleme

tekniğiyle belirlenmesi. Tarım Bilimleri Dergisi, 13 (3): 176-185.

200

PO-69

Anticancer and Antioxidant Activity of Porodaedaleapini (Brot.)Murrill Ebru DEVECİ, Gülsen TEL ÇAYAN, Mehmet ÖZTÜRK,Selçuk KÜÇÜKAYDIN, Mehmet Emin DURU

aMuğla SıtkıKoçman University, Faculty of Science, Department of Chemistry48121 Kötekli Muğla, Türkiye

Abstract:

Antioxidants are substances which inhibit or retard to oxidation in the starting and/or development step. Compounds having antioxidant activity is an important need for life in living organisms. Lack of antioxidants causes many diseases i.e. cancer, diabetes, arthritis, Parkinson's disease, brain and heart disease [1] Cancer is a substantial health threat in all over the world, and the biggest cause of death in peoples of various age groups [2]. Hence, consumption of antioxidants compounds have been provided protection against cancer, cardiovascular diseases, diabetes and other aging-based diseases by reducing oxidative stress. Mushrooms are the source of polysaccharides having anticancer and anti-immunomodulatory activities[3]. Therefore mushrooms compounds very important source of drugs for modern medicine. In this study, Porodaedaleapiniwas extractedwith hexane, methanol and water at room condition. The anticancer activity of extracts was tested against Prostate cancer (PC3), while the cytotoxic activity was tested against mouse fibroblast (3T3). In addition, antioxidant activity of extracts was performed by β-carotene-linoleicacid, DPPH•scavenging, ABTS•+scavenging, cupric-reducingantioxidantcapacity (CUPRAC) andmetalchelatingassays. The methanol extract showed the highest anticancer activity against mouse fibroblast (3T3) with the IC50 value of 38.053±0.141 µg/mL, whereas the hexane extract exhibited the highest activity against Prostate cancer (PC3) indicating IC50=33.846±0.003 µg/mL.As for antioxidant activity results, the methanol extract showed higher activity in all antioxidant assays. Authors would like to thank The Scientific and Technological Research Council of Turkey (TUBITAK-114Z550) forfinancialsupport. References

1. L. Packer, E. Cadenas; Handbook ofAntioxidants. 2nd Edn., New York, Basel, USA, Marcel Dekker, 2002.

2. A.K. Sharma, M. Gupta, A. Shrivastav, A. M. Jana;Int. J. Pharma. Sci. Res.2013, 4, 3795-3802. 3. M. Emin Duru, G. Tel Çayan. (2015). ”BiologicallyActiveTerpenoidsfromMushroomorigin: A

Review” Records of Natural Products, 9:4, pp.456-483.

201

PO-70 The Chemical Composition of Essential Oil

and Anticholinesterase Inhibition Activity of Various Extracts of Thymus cilicicus Boiss. & Bal.

Selçuk KÜÇÜKAYDINa, Mehmet Emin DURUa, Erhan KAPLANERa Gülsen TELa, Meltem TAŞa, Gülay ŞAVKINCIa

aMuğla Sıtkı Koçman University, Faculty of Science, Department of Chemistry48121 Kötekli Muğla, Türkiye

Abstract: Alzheimer’s disease, which is a progressive neurological disorder in the brain, is one of the major health problems, in industrialized countries, because of ageing populations.Up to date, pathogenesis of Alzheimer’s disease has not been fully clarified. However, the valid hypothesis being accepted is the lack of in amount of acetylcholine which is a neuromediator[1]. Herewith, acetylcholinesterase inhibitor drugs are used for treatment of Alzheimer's disease. However, most of these drugs have side effects. Therefore, the development and utilization of more effective antioxidants and anticholinesterase compounds of natural origin are desired[2]. The genus Thymus L. is a member of Lamiaceae family and rep-resented by 318 species in the world, 40 species in Turkey and 20 of them are endemic for Turkey. The plant is named as “Kekik” in Turkey and consumed as herbal tea, spicy and folk medicine[3]. In this study, the chemical composition of essential oils of “Thymus cilicicus“ was analyzed. As well as chemical composition of essential oils, anticholinesterase enzyme inhibition activity of the hexane, acetone and methanol extracts from the aerial parts of the plant has been studied. The aerial parts ofT. cilicicus were identified and collected from southern of Turkey (Muğla) in July 2013.Essential oil was obtained using a Clevenger apparatus from the dried aerial parts of and T. cilicicus. Chemical compositions of essential oils analyzed by GC and GC-MS and and total 26 constituents were identified.The main components of the essential oil were borneol (16,97%),eucalyptol (16,78%) andcamphor (12,54%). In addition to, Acetylcholinesterase and butyrylcholinesterase inhibitory activity was measured, by slightly modifying the spectrophotometric method developed by Ellman et al. (1961)[4].The acetone extract of T.cilicicus among the extracts (52,86±1,08%) showed the best inhibitory activity against AChE enzyme, and followed by the methanol extract (46,66±0,86%) at at 200 µg/mL concentrations..The acetone extract of T. cilicicus (58,48±0,85%) exhibited the best BChE inhibitory activity, and followed by the essential oils of T.cilicicus (50,10±0,60%). At the same concentrations, the galantamine showed 80.41±0.98% and 82.23±2.67% inhibitory activities, respectively.

References

1. Grossberg GT (2003). Cholinesterase inhibitors for the treatment Of Alzheimer's disease: Getting on and staying on. Current Ther Res 64, 21"35.

2. G. Tel, M. Öztürk, M.E. Duru, M. Harmandar, G. Topçu, Food Chem. Tox. 48, (2010), 3189-3193. 3. P.H. Davis, Flora of Turkey and the East Aegean Islands, Supplement 1, (1988), Edinburgh University

Press, Edinburgh. 4. G.L. Ellman, K.D. Courtney, V. Andres and R.M. Featherston, Biochem Pharmacol. 7, 88-95 (1961)

202

PO-71 Acetazolamide Derivative Novel Acridindione Compounds as Carbonic Anhydrase

Inhibitors*

Ramazan ULUS,Burak ADAY,Muharrem KAYA Dumlupınar University, Faculty of Science and Art, Department of Chemistry, 43100, Kütahya, TURKEY / Tel: + 90-274-2652051-3704

[email protected] Abstract: Acridindiones are heterocycle compounds and this compounds containing nitrogen is the core structure of a number of biologically interesting compounds. Acridindione derivatives are known to exhibit diverse bioactivities such as anti-microbial, anti-fungal, anti-tumor, cytotoxic, anti-cancer, and multidrug-resistant actions, anti-glaucoma and they are widely prescribed as calcium β-blockers. So far, a great number of acridine compounds have been synthesized and clinically used as anthelmintic, antimalarial, and antibacterial agents. In addition, sulfonamides are very important compounds for the medicine industry and they are now extensively used drugs for the treatment or conservation of different illnesses. In clinical medicine, they have been used as anti-cancer, anti-obesity, diuretics, carbonic anhydrase inhibitors, and anti-convulsant agents [1,2]. In this study, acetazolamide containing new amine compound, dimedone and various aromatic aldehydes were performed Aldol, Michael and cyclization reactions. According to MCR (Multi Component Reaction) this reactions are realized one-step using microwave-assisted synthesis process. Literature without registration novel acridindione-acetazolamide compounds were synthesized by this method [2]. Then, these compounds were characterized by IR, 1H-NMR and 13C-NMR data and high resolution mass spectral analyses, respectively.

Scheme1.Synthesized novel acridine acetazolamide compounds


References

1. R. Ulus, İ. Yeşildağ, M. Tanç, M. Bülbül, M. Kaya, C.T. Supuran, Bioorganic & Medicinal Chemistry, 2013, 21, 5799-5805.

2. J. Marco-Contelles, et all., Journal of Medicinal Chemistry, 2009, 52, 2724–2732.

203

PO-72 EfficientSynthesis of Tetrazole Derivatives Catalyzed by Recyclable Platinum

Nanoparticles as Heterogeneous Catalyst under the Microwave Irradiation

EsmaERKENa, İbrahim ESİRDENb, Muharrem KAYAa,Fatih ŞENa

aBiochemistry Department, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus 43100

Kütahya, Turkey bChemistry Department, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus 43100

Kütahya, Turkey

Abstract: Tetrazoles are heterocyclic compounds having a five membered ring containing one carbon atom and four nitrogen atoms.Tetrazoles have been captivating increasing attention, due to their wide application, such as they show strong activities in pharmaceutical chemistry as antimicrobial,antibacterial, antifungal and antihypertensive drugs. Additionally, these nitrogen-rich ring systems have many applications in material science including photography, propellants and explosives. Because of these important applications, recently, various methods have been reported for the synthesis of tetrazoles. Herein we report platinum nanoparticles (Pt NPs)stabilized by propylamine ligand and activated carbon (AC) as a new heterogeneous catalyst for synthesis of tetrazole derivatives with superior catalytic activity. The current PtNPs@AChave been used for the first time for these types of synthesis reactions.

a b c d e f

R -H -NO2 -Br -Cl -CHO -CH3

*This study is supported by Dumlupınar University Research Fund (Grant Number: 2014-62).

References

1. A.Dişli, S.Mercan, S.Yavuz;J.Heterocycl. Chem.2013,50, 1446. 2. M.Ahmad Malik, S.A.Al-Thabaiti, M.A.Malik;Int. J. Mol. Sci.2012, 13, 10880. 3. E.P.Ellis, G.B.West; Biomedical Press1980, 17, 151. 4. L. M. T.Frija, A.Ismael, M. L. S.Cristiano;Molecules2010, 15, 3757. 5. R.Damavarapu, T. M.Klapötke, J.Stierstorfer, K. R.TarantikPropellants Explos.Pyrotech.2010, 35, 395.

204

PO-73 Synthesis of 5-Amino-1,3,4-thiadiazole-2-sulfonamide based novel acridindione

compounds* Burak ADAYa, Ramazan ULUSa, Muharrem KAYAb

aChemistry Department, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus 43100 Kütahya, Turkey.

bBiochemistry Department, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus 43100

Kütahya, Turkey.

Abstract: Acridinedione molecules are one of the important classes of heterocyclic compounds that is containing nitrogen atom and they are planar tricyclic aromatic molecules. These molecules were discovered at 19 th century and their synthesis and application have been widely studied until today. Recently, acridinedione-based compounds have been reported to many important biological properties such as antioxidant,anti-multidrug-resistant, effective photodynamic therapy agent,β-channel opener in cardiovascular disease and as carbonic anhydrase inhibitor for glaucoma treatment. Sulphonamides are another important compounds family for the medicine industry and they are now extensively used drugs for the treatment or conservation of different illnesses. In clinical medicine, they have been used as anticancer, antimicrobial, carbonic anhydrase inhibitors and acetylcholinesterase inhibitor agents for Alzheimer’s disease. In this study, novel acridindione compounds were formed by means of a one-pot reaction producing high yields and providing a simple work-up procedure by assisted microwave using new amine compound, dimedone and various aromatic aldehydes.Then, these compounds were characterized by IR, 1H-NMR and 13C-NMR data and high resolution mass spectral analyses, respectively.

Scheme1.Synthesized novel acetazolamide containing acridinedione-sulphonamide derivatives


References

1. S.Singh, S.Chhina, V. K.Sharma, S.S.Sachev, J. Chem Soc. Chem. Commun,.1982, 8, 453-454.

205

PO-74

Highly Dispersed Platinum Nanoparticles Supported with Graphene Oxide for the One-Pot Synthesis of Acridinedione Derivatives*

Burak ADAYa, Handan PAMUKb, Fatih Senb,Muharrem KAYAb aChemistry Department, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus 43100

Kütahya, Turkey. bBiochemistry Department, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus 43100

Kütahya, Turkey.

Abstract: Acridinedione derivatives which have similarities in structure to NADH have important biological actives as anticancer, anti-glaucoma, β-channel opener in cardiovascular disease. In addition to this application, they one are known as laser dyes and intercalated accent. Recently, various methods have been reported for the synthesis of acridinedione. Herein, we report Platinum Nanoparticles Supported with Graphene Oxide (Pt NPs@GO) as a new heterogeneous catalyst for synthesis of acridinedione with higher catalytic activity. The current Pt NPs @ GO have been used for the first time for these type of acridinedione synthesis reactions. There is, therefore, scope for discovery of new catalyst with mild reaction condition, short reaction time, better yield, environmentally friendly and high recovery. The synthesized catalyst was characterized by X‐ray diffraction (XRD), transmission electron microscopy (TEM), the high resolution electron micrograph (HRTEM), atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS) applications of the catalysts were performed by synthesis of acridinedione.

Scheme1.Synthesized acridinedione derivative compounds

*This research was financed by Dumlupınar University Research Fund (Grant No. 2014-62 and 2014-05). The

partial supports by Science Academy are gratefully acknowledged.

References

1. S.A. Gamage, J.A. Spicer, G.J. Atwell, G.J. Finlay, B.C. Baguley, W.A. Denny, J. Med. Chem.,1999, 2383-2393.

2. M. Kaya, E. Basar, E. Çakir, E. Tunca, M. Bulbul,. J. Enzyme Inhib. Med. Chem.,2012, 27:509-514. 3. R. Ulus, İ. Yeşildağ, M. Tanc, M. Bülbül, M. Kaya, C.T. Supuran. Bioorg. Med. Chem.2013, 21:5799-

5805.

206

PO-75 One-Pot, Facile, Highly Efficient, and Clean Synthesis of Acridinedione Derivatives using

Vitamin B1 as a Catalyst *

Burak ADAYa, Ramazan ULUSa, Ahmet IŞIKa, Muharrem KAYAb aChemistry Department, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus 43100

Kütahya, Turkey. bBiochemistry Department, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus 43100

Kütahya, Turkey. Abstract: Acridinedione derivatives of 1,4-dihydropyridine are compounds having interesting biological features which are similar to the structure of Nicotinamide Adenine Dinucleotide (NADH), an important co-enzyme found in cells. Acridinedione compounds are reported that they can be used as anti-tumor, cytotoxic, β-channel opener in cardiovascular disease, and as carbonic anhydrase inhibitor for glaucoma treatment. Vitamins B1 are very environment friendly substances when compared to other catalysts. For this reason they are used in many organic reactions as catalysts such as benzoxanthene,1H-benzimidazoles,quinoxalines,1,4-dihydropyridines. In this study, dimedone, various aromatic amine and various aromatic aldehydes were performed Aldol, Michael and cyclization reactions.This reactions are realized one-step using a knowing synthesis method. The synthesized compounds were characterized by IR, 1H-NMR and 13C-NMR data and high resolution mass spectral analyses, respectively.

Scheme1.Synthesized acridinedione derivative compounds

References

1. S. Singh, S. Chhina, V. K. Sharma, S.S. Sachev, J. Chem Soc. Chem. Commun,.1982, 8, 453-454. 2. M. Kaya, Y. Yıldırır, G.Y. Çelik, Med. Chem. Res.,2011, 20, 293–299. 3. T.S. Jin, J.S. Zhang, T.T. Guo, A.Q. Wang, T.S. Li, Synlett, 2004, 12, 1425–1427.

207

PO-76 Synthesis of Thioxanthone Based Water Soluble Copolymeric Macrophotoinitiator and

Its Use in Photoinduced Free Radical Polymerization*

Meral AYDINa, Nuket OCAL a, Nergis ARSUa

aDepartment of Chemistry,Faculty of Art and Science, Yildiz Technical University, Davutpasa Campus, 34210, Istanbul Turkey

Abstract: Photoinitiators are one of the important constituents of photopolymerizable formulations since photopolymerization has a wide range of applications such as for coatings, microelectronics, printing plates, adhesives and inks . There have been many new developments in synthesis and photochemical studies of novel polymeric photoinitiators. Polymeric photoinitiators have attracted much attention in the past years, for they combine the properties of polymers with those of low molecular weight photoinitiators. Solubility and miscibility problems, often observed with coatings containing low molecular weight photoinitiators , do not occur with the polymeric ones since polymers are easily miscible with the resin to be cured as well as with the final, cured film. Moreover, odor and toxicity problems do not occur with macrophotoinitiators owing to the low volatility of the large molecules. The low migration tendency of polymeric photoinitiators and of photoproducts means that cured coatingsare less prone to yellowing [1-3]. In this study,a thioxanthone based water soluble copolymeric macrophotoinitiator (KB-TX) was synthesized and characterized. Its capability to act as initiator for the poymerization of acrylamide and different acrylates systems was examined.

*This study is supported by Yildiz TechnicalUniversity ResearchFund. (Project Number:2009-01-02-KAP03)

References

1. J.P. Fouassier, Photoinitiation, Photopolymerization and Photocuring, Hanser Verlag, Munich,1995. 2. G. Temel, N. Arsu, Y. Yagci, Polym. Bull, 2006, 57, 51-56. 3. G. Temel, N. Arsu, J. Photochemisry and Photobiology A : Chem.Polym, 2009, 202, 63-66.

208

PO-77 Ultrasound-promoted Synthesis of Tetrahydropyridine Derivatives in presence of

M(OTf)x* Zühal Turgut a, Emel Pelit b, Oğuz Rıdvan Dürüsta

aYildiz Technical University, Faculty of Art and Sciences, Department of Chemistry, 34220, Davutpasa Campus, Istanbul, Turkey bKirklareli University, Faculty of Art and Sciences, Department of Chemistry, Kayali Campus, 39100, Kirklareli, Turkey

Abstract: The tetrahydropyridines are important heterocycles, which constitute the core structures of a variety of natural products and pharmaceuticals [1]. As a consequence, the development of general methods for the synthesis of piperidine derivatives has been the subject of considerable synthetic efforts and still requires attention [2-4]. Triflates are effective and recoverable homogeneous catalysts for the modern synthesis. [5]. A series of highly functionalized tetrahydropyridines have been synthesized by the condensation of β-keto-esters, aromatic aldehydes and anilines catalyzed by Y(OTf)3 (5 mol %)under ultrasound irradiation. For the comparison the reactions were carried out under both conventional and ultrasonic conditions.

CHO

R1 +

CH3 OCH3

O O

+ R2NH2

Y(OTf) 3

US N

OCH3

NHR

2

O

R2

R1

R1

2 2

Scheme1. Synthesis of highly substituted tetrahydropyridines using Y(OTf)3

The structures of the obtained compounds have been clarified by spectroscopic methods (FTIR, 1H NMR, 13C NMR, EA and MS) after the purification processes. *This study was financially supported by YILDIZ TECHNICAL UNIVERSITY with the project number of BAPK 2012-01-02-KAP05. References

1. A. T. Khan, M. Khan, K:R. Bannuru, Tetrahedron,2010, 66, 7762. 2. S.Khaksar, S. M. Vahdat, M. Alipour, C. R. Chimie, 2013, 16, 1024. 3. R. Ghorbani-Vaghei, R. Karimi-Nami, Z. Toghraei-Semiromi, M.Amiri, M. Ghavidel, Tetrahedron, 2011, 67, 1930. 4. M. Kidwai,, A. Jahan, R. Chauhan, N.K. Mishra, Tetrahadron Letters, 2012, 53 , 1728. 5.S. Kobayashi,M. Sugiura, H. Kitagawa and W. Lam, Chemical Reviews, 2002, 102, 6, 2227.

209

PO-78 Three- Component, One-pot Synthesis of Indeno[1,2-b]Quinoline-7-one Derivatives

Catalyzed by Triflat*

Zühal TURGUT, Özlem ELMAS, Kadir TURHAN,

Yildiz Technical University, Faculty of Art and Sciences, Department of Chemistry, TR-34220, Davutpasa Campus, Istanbul, Turkey

Abstract: Quinoline derivatives are important class of N-containing heterocycles; they are present in a wide variety of naturally occurring alkaloids with pharmacological properties [1], and they are useful for dyes and intermediates in organic synthesis [2]. Various methods have therefore been developed for the synthesis of substituted quinolines [3]. Multicomponent reactions (MCRs) are special types of synthetically useful organic reactions in which three or more different starting materials react to a final product in a one-pot procedure. Rare earth metal triflates, a new type of Lewis acid were widely applied in organic synthesis due to their low toxicity, high stability, ease of handling, water tolerance and recoverability from water [4]. In this study, indeno[1,2-b]quinoline-7-one compounds have been obtained through a one-pot condensation of various substituted aromatic aldehydes, 1-naphthylamine, and 1,3-indandione in the presence of M(OTf)x as a green and reusable catalyst.

Scheme1. Synthesis of indeno[1,2-b]quinoline-7-one derivatives

The structures of the obtained new compounds have been clarified by spectroscopic methods (FTIR, 1H NMR, 13C NMR, EA and MS) after the purification processes. *This study was financially supported by YILDIZ TECHNICAL UNIVERSITY with the project number of BAPK 2014-01-02-YL07.

References

1. N. G. Khaligh, Chinese Journal of Catalysis, 2014, 35, 474-480 2. J. L. Donelson, R. A Gibbs and S. K. De, Jounal of Molecular Catalysis A: Chemical, 2006, 256, 309-3011. 3. S. Abdolmohammadi, Chinese Chemical Letters, 2013, 24,318-320. 4. I. Nakamura, M. Kamada and Y. Yamamoto, Tetrahedron Letters, 2005, 45, 2903.

O

O

+ ArCHO

NH2

M(OTf)x

NH

O Ar

,1 32

+

4

210

PO-79 Biological Activities of Flowers and Peel Oils of Citrus aurantium L. Growing in Turkey

Seda Güreli Feridun, Selçuk Altun, Ayşe Ogan, Ümit Salan Marmara University,Department of Chemistry, 34722 Göztepe-İstanbul, Turkey

[email protected] Abstract: Citrus aurantium L. (Rutaceae family), also known as sour orange or bitter orange, is generally used as a rootstock and has a number of advantages, including resistance to several viral diseases, tolerance to cold, improvement in the fruit quality of the grafted plants.1Citrus aurantium L. is among the species that have been used for medicinal purposes2-4on account of the various bioactive compounds that it contains, such as phenolics, flavonoids, essential oils, and vitamins. In this study, Citrus aurantium L. were collected during two different vegetation periods, flowering and fruiting seasons from Heybeliada-İstanbul. The objective of this study was to determine antiobesity and Alzheimer’s disease activities of the extracts of Citrus aurantium L. flowers and fruits. Dried flowers and fruits of the plant were extracted with hexane at room temperature. Alzheimer’s disease and antiobesity treatmentactivities found in the fractions of Citrus aurantium L. flowers and peel. Isolation and structure elucidation studies on the active fractions are being carried out to determine the potentially active principles of this plant.

References

1. E. Sarrou, P. Chatzopoulou, K. Dimassi-Theriou and I. Therios; Molecules,2013, 18, 10639-10647. 2. S. Kumari, N. Sarmah, A. K. Handique; International Journal of Innovative Research in Science,

Engineering and Technology,2013, 2, Issue 9, 4811-4816. 3. W. Chaiyana, S. Okonogi; Phytomedicine, 2012, 19, 836-839. 4. M. A. Anagnostopoulou, P. Kefalas, V. P. Papageorgiou, A. N. Assimopoulou, D. Boskou; Food

Chemistry, 2006, 94, 19–25.


211

PO-80 Investigation of Mechanical Properties Of Nonwoven Felt- Polypropylene-Pumice

Composite Materials

Yalcin BOZTOPRAKa, Sabih OVALIb, Mahmut KAYARb, Yeşim Müge ŞAHİNc

aDepartment of Metallurgy and Material Engineering,Faculty of Technology, Marmara University, İstanbul, Turkey bDepartment of Textile Engineering, Faculty of Technology,Marmara University, İstanbul, Turkey

cDepartment of Biomedical Engineering, Faculty of Engineering and Architecture, İstanbul Arel University, İstanbul, Turkey

Abstract: Polypropylene is a major volume thermoplastic material due to ist cost effectiveness, versatility, overall competitiveness and excellent environmental aspects. Excellent wear and resistance to staining associated with low cost have led to uses in woven and non-woven form for carpeting in indoor and outdoor constructions, for clothing, inner liners, drapes, tez bags, wall coverings, furniture and automotive upholstery and for ropes and netting. Pumice is volcanic rock type, pores usually has connections with each other. Dimensions from the dimensions contained are numerous microscopic pores that can be seen with the naked eye and each one is covered with a glassy membrane. So lightweight, floating for a long time, the isolation of a rock. Felts represent the oldest form of textile fabric. Animal fibers such as wool and, to a degree, fur are accepted as the only true feltable fibers. Forming them into felts requires preliminary compaction or hardening followed by additional mechanical working with addition of heat and usually moisture. Felting of other iilamentary materials has not been possible, and felt-like productsv composed of them not been made heretofore. The aim of this study ismanufacturing of composite structures by using nonwoven felt, polypropylene and pumice in different ratios and to investigate the mechanical properties of the composites. It was obtained that composite structures have excellent mechanical properties.

References

1. F. Dorel, B, ALLA, Synthetic Polymers, 1996, 273. 2. X. D. Zhang, C. W. Macosko, H. T. Davis, A. D. Nikolov and D. T. Wasan, ,Role of Silicone Surfactant

in Flexible Polyurethane Foam, Journal of Colloid and Interface Science,1999, 215, 270–279 3. H. G. Lauterbach,Felt-like products, 1955, Publication number: US 2910763 A

212

PO-81 Synthesis and Characterization of Novel Metallophthalocyanines*

Esra KAKIa, Nurcan GÖGSUa, Bekir SALİHb, Özer BEKAROĞLUc

aDepartment of Chemistry, Marmara University, 34722, Göztepe, Istanbul, Turkey bDepartment of Chemistry, Hacettepe University, 06532, Ankara, Turkey

cDepartment of Chemistry, Technical University of Istanbul, Maslak, Istanbul, Turkey

Abstract:

Phthalocyanines, owing to properties such as strong delocalized 18 π-electron system, thermal stability and visible area optical properties, have been extensively studied due to their various technological applications, such as nonlinear optics [1] gas sensors[2], liquid crystals [3], solar cells [4] and electrochromism [5]. These compounds continue to be subject of the increasing research efficiency. In this study, the precursor[4,4’-hex-3-ene-3,4-diyl)bis(4,1-phenylene))bis(oxy)diphthalonitrile] was synthesis by the reaction of 4-nitrophthalonitrile and diethylstilbestrol in dry DMF in presence of dry K2CO3. The new mononuclear phthalocyanines [Co(II), Zn(II) and Cu(II)]were obtained from starting material by addition of the corresponding metals salts [Co(OAc)2.4H2O, Zn(OAc)2.2H2O, Cu(OAc)2]. The novel compounds were characterized by elemental analysis, IR, UV-Vis, 1H-NMR and MALDI-TOF mass spectroscopy techniques. * This study is supported by a grant (Project No: Science-C-YLP-121114-0360) from Marmara University The Commission of

Scientific Research Projects.

References

1. De.G. La Torre, P. Vazquez, F. Agulla-Lopez, T. Torres, Chemical Reviews, 2004, 104, 3723-3750. 2. E. Kakı, A.Altındal, B. Salih, Ö. Bekaroğlu, Dalton Trans., 2015, 44, 8293-8299. 3. C.C.Leznoff, A.B.P.Lewer, Phthalocyanines, Properties and Applications Vol.2, VCH Publiesher, New York, 1993. 4. F.Yang, S.R.Forrest, American Chemical Society Nano, 2008, 2, 1022-1032. 5. Ş.Abdurrahmanoğlu, A.R.Özkaya, M.Bulut, Ö.Bekaroğlu, Dalton Trans., 2004, 4022-4029.

213

PO-82

Investigation Of Sound Permeability Of Nonwoven Felt- Polypropylene-Pumice Composite Materials

Yalcin BOZTOPRAKa, Sabih OVALIb, Mahmut KAYARb, Yeşim Müge ŞAHİNc

aDepartment of Metallurgy and Material Engineering,Faculty of Technology, Marmara University, İstanbul, Turkey

bDepartment of Textile Engineering, Faculty of Technology,Marmara University, İstanbul, Turkey cDepartment of Biomedical Engineering, Faculty of Engineering and Architecture, İstanbul Arel University, İstanbul, Turkey

Abstract:

Polypropylene is a crystalline polymer and the rate and manner in which the crystals have been formed from the melt influence the crystalline structure. This in turn largely determines both physical properties and processing characteristics of the polymer. Syndiotactic PP, which is not yet commercially available, has lower Tm, better impact resistance and more clarity than isotactic PP. Pumice is volcanic rock type, pores usually has connections with each other. Dimensions from the dimensions contained are numerous microscopic pores that can be seen with the naked eye and each one is covered with a glassy membrane. So lightweight, floating for a long time, the isolation of a rock. Felts represent the oldest form of textile fabric. Animal fibers such as wool and, to a degree, fur are accepted as the only true feltable fibers. Forming them into felts requires preliminary compaction or hardening followed by additional mechanical working with addition of heat and usually moisture. Felting of other iilamentary materials has not been possible, and felt-like productsv composed of them not been made heretofore. Although felts containing synthetic fibers blended with conventional felt-forming fibers are known, the synthetic component has occupied a secondary role in the felt formation, although perhaps endowing the product with desirable qualities, such as improved abrasion resistance and dimensional stability. The aim of this study ismanufacturing of composite structures by using nonwoven felt, polypropylene and pumice in different ratios and to investigate the sound absorbance properties of the composites. It was obtained that composite structures have excellent sound absorbance properties.

References

1. F. Dorel, B, ALLA, Synthetic Polymers, 1996, 273. 2. X. D. Zhang, C. W. Macosko, H. T. Davis, A. D. Nikolov and D. T. Wasan, ,Role of Silicone Surfactant

in Flexible Polyurethane Foam, Journal of Colloid and Interface Science,1999, 215, 270–279 3. H. G. Lauterbach,Felt-like products, 1955, Publication number: US 2910763 A

214

PO-83

UV Curable Polyurethane Coating Materials Based Siloxane and Investigation of Their Thermal Properties

Mert ÇINARa, Sevim KARATAŞa

aDepartment of Chemistry,Faculty of Art and Science, Marmara University, TR34722, Istanbul-Turkey

UV-curing technology has been considered as an alternative to traditional solvent-borne coatings, due to its eco-compatible process and excellent properties resulting from the high cross- link density. On the other hand, acrylic monomers and oligomers are used widely. However, they have poor thermo-mechanical stability. Therefore, the cross-linking of multifunctional acrylates is needed to increase their thermo-mechanical stability.1

UV-curing polyurethane acrylates are preparedby reacting isocyanates with hydroxyl functional acrylates.Versatile chemistry of polyurethane acrylates allowcoatings with good flexibility, toughness, abrasion resistance,adhesion, chemical resistance, and excellentweathering resistance2.Additionally, Poly(dimethylsiloxane)-based materials also have received much attention because of exceptionally low Young’smodulus, low glass transition temperature, gas permeability, and furthermore, low surface energy, high thermal and chemical stability and low dielectric constants.

The objective of this study is to synthesis a new UV-Curable polyurethane acrylates based siloxane and to investigate their coating applications on Plexiglass® substrate. The effects of siloxane on the physical, mechanical and thermal properties of the UV-cured hybrid coatings were systematically investigated. Moreover, the nanostructure of the hybrid materials was examined . Acknowledgement: Financial support from Marmara University Science Fund (BAP No. FEN-C-YLP-080415-0128).

References

1. S-W. Lee , J.-W. Park , C.-H. Park , D.-H. Lim , H.-J.Kim a,n, J.-Y. Song , J.-H. Lee . 2013 International Journal of Adhesion & Adhesives 44 , 138–143.

2. G. Webster, ., 1997,Chemistry and Technology of UV and EB Formulationfor Coatings, Inks, and Paints: Prepolymers and

Reactive Dilutentsfor UV and EB Curable Formulations, John Wiley and Sons, New

215

PO-84

Synthesis and Characterization of UV Curable Waterborne Polyurethanes

Tülin GACALa, Gökhan TOPÇUa , Sevim KARATAŞa

aDepartment of Chemistry,Faculty of Art and Science, Marmara University, TR34722, Istanbul-Turkey TheUV-curing technique is becoming increasingly important in the field of coatings1. It induces the polymer formationwith a fast conversion from a liquid composition to a solid filmwith desirable physical–chemical and mechanical properties. The technique based onUVirradiation has attractive advantagessuch as high-speed process, lower energy consumption due tothe operation at room temperature, lower process costs, highchemical stability and environmental friendliness by avoidingsolvent exposure. The waterbased UV-curable systems appear asa promising supplement by eliminating the use of acrylatemonomers, water being used as the only diluent.The potential of waterborne systems and their performancein UV-radiation curing have been thoroughlyinvestigated in the past decade . Most of them consistof a dispersion or emulsion of acrylate functionalizedoligomers which are photocrosslinked in the solid state,after removal of the water.2

The purpose of this work was to synthesis of a series UV curable waterborne polyurethane acrylates (WPUA) and evaluate some properties of them. In this context, UV curable urethane acrylate oligomers (UA) were prepared from isophronediisocyante (IPDI), Polyethyleneglycol 1500 (PEG1500), dimethylolpropanoic acid (DMPA) and 2-hydroxylethylacrylate (HEMA). Besides that, [2, 2 bis (4-β-hydroxyethoxy) phenyl propane] (HEPA) was prepared by the rections of bisphenol A and ethylene carbonate. Addition, acrylated HEPA was prepared from HEPA and acryoilchloride. In addition, sol-gel solution was prepared from [(tetraethoxysilane (TEOS) and (3-methacryloxypropyl) silane (MAPTMS)].The effectsof acrylated HEPA and silica content on the physical, mechanicaland thermal properties of the UV-cured coatings were systematically investigated.Moreover, the nanostructure of the hybrid materials was examined . Acknowledgement: Financial support from Marmara University Science Fund (BAP No. FEN-A-120613-0270). References

1. Karataş S, Hoşgör Z, Kayaman-Apohan N, Güngör A, Progress in Organic Coatings200965: 49–55. 2. K. Doren, P. Freitag, D. Stoye, in: Hanser (Ed.), Water-BorneCoatings, The Environmentally Friendly Alternative, 1994, p.

204.

216

PO-85

Synthesis and Characterization of Novel Pyridone Derivative Phthalocyanines Şaziye ABDURRAHMANOĞLUa, Büşra MIZRAKa

aDepartment of Chemistry,Faculty of Art and Science, Marmara University, TR-34722, İstanbul, Turkey Abstract: Metal-free (H2Pc) and metallophthalocyanines (MPc), have been a very important class of dyes and pigments since their early

synthesis [1] . Various modifications have been made on these complexes to improve their performance as advanced materials

[2,3]. In this study, it was carried out to synthesize novel pyridone derivatives metal-free (4) and simetrical cobalt(II) (5)

phthalocyanines to improve brightness. For this purpose; starting with 4-nitrophthalonitrile (1) and 4-hydroxy-6-methyl-3-nitro-2-

pyridone (2), 4-(6-methyl-3-nitro-2-oxo-1,2-dihydropyridin-4-yloxy)phthalonitrile (3) was prepared. Then metal-free phthalociyanine

(4) and Co(II) phthalocyanine (5) were synthesized by using3, metal Li and cobalt(II) acetate tetrahydrate in amyl alcohol,

respectively

Scheme1.Synthesis of compunds 3, 4 and 5, reagents and conditions. (i) K2CO3, DMF, 50oC, 36 h. (ii) Li metal, Amyl alcohol, 12 h (iii) Co(OAc)2.4H2O, amyl alcohol, 10 min. 320oC.

*This study is supported by a grant (Project FEN-A-101013-0397) from The Commission of Scientific Research Projects of Marmara University

References

1. C. C. Leznoff_, A. B. P. Lever; Phthalocyanines: Properties and Applications; VCH: New York, NY, USA, 1993.

2. S. Abdurrahmanoglu, A. Altındal, A. R. Özkaya, M. Bulut, Ö. Bekaroglu;Chem. Commun.2004, 2096. 3. S. Abdurrahmanoglu, A. Altındal, M. Bulut, Ö. Bekaroglu; Polyhedron, 2004, 3639-3646.

217

PO-86 Synthesis and Characterization of Novel structure Co(II) phthalocyanine

Şaziye ABDURRAHMANOĞLUa, Büşra MIZRAKa aDepartment of Chemistry,Faculty of Art and Science, Marmara University, TR-34722, İstanbul, Turkey

Abstract: Phthalocyanines have interesting and uniq electronic and physical properties becaus of their high conjugation [1] . Recently, to

improve these properties many phthalocyanines were desingned by changing metals and substituents [2,3]. The aim of this study is

to synthesize novel structure phthalocyanine. For this porpose; starting with 2-hydroxy-4-methyl-pyridin (2)and 3-

nitrophthalonitrile (1),3-(4-methylpyridin-2-yloxy)phthalonitrile (3) was prepared in N,N-dimethylformamide (DMF). Then, novel and

1(4),8(11),15(18),22(25)-tetrakis[4-methylpyridin-2-yloxy]phthalociyaninato cobalt(II)(4)were obtained by the reaction of 3 with

Co(OAc)2.4H2O in dry amyl alcohol. All compounds were characterized by elemental analysis, FT-IR, Uv-vis, 1H-NMR and MALDI-TOF

mass spectroscopy.

Scheme 1. Synthesis of compunds 3 and 4, reagents and conditions. (i) K2CO3, DMF, 50oC, 36 h. (ii) Co(OAc)2.4H2O, Amyl alcohol, 10

min. 320oC *This study is supported by a grant (Project FEN-C-YLP-121214-0391) from The Commission of Scientific Research Projects of

Marmara University

References

1. C. C. Leznoff_, A. B. P. Lever; Phthalocyanines: Properties and Applications; VCH: New York, NY, USA, 1993.

2. S. Abdurrahmanoglu, A. Altındal, A. R. Özkaya, M. Bulut, Ö. Bekaroglu;Chem. Commun.2004, 2096. 3. H. G. Yağlıoğlu, M. Arslan, S. Abdurrahmanoglu, H. Ünver, A. Elmalı, Ö. Bekaroglu; PJ. Phys. Chem.,

2008, 69, 161-167.

218

PO-87 Determination of Trace Metals on Some Mushroom Species by ICP-OES after Microwave

Digestion Method

Muhammet Emre HISIR, Esra ALTINTIG, Hüseyin ALTUNDAG Department of Chemistry, Faculty of Art and Science,Sakarya University, TR-54187, Sakarya, Turkey

Abstract: Turkey is a rich country in terms of edible mushroom because of the climate conditions. Eatable mushroom is able to be grown in various regions of our country and consumed as food by collecting in their proper seasons. By the way mushroom is also important in terms of trace metals accumulation [1,2]. In this study, the concentrations of trace elements in 12 different edible mushroom species collected from Sakarya region of Turkey were determined by ICP-OES after microwave digestion method.The collected samples were dried at105°C for 24 h. Dried samples were homogenizedusing an agate homogenizer and stored in polyethylenebottles prior to analysis. All the plastic wareand glassware were cleaned by soaking overnight ina 10% nitric acid solution and then rinsed with deionizedwater.One gramme of sample was digested with 6 ml of HNO3 (Suprapure, Merck), 2 ml of H2O2 (Suprapure, Merck) in a microwave digestion system for 31 min and diluted to 10 ml with double-deionized water(Milli-Q Millipore, 18.2 MΩ cm resistivity).The accuracy of the method was corrected by standardreference material. The obtained results will be presented in 1st International Turkic World Conference on Chemical Sciences and Technologies (ITWCCST). *This study is supported by a grant (Project Number: 2014-02-04-009) from Scientific Research Projects Committee of Sakarya

University.

References

1. M. Tüzen, M. Özdemir, A. Demirbaş, 1998b, Z Lebensm Unters Forsch A 206, 417-419. 2. O. Işıldak, I. Türkekul, M. Elmastas, M. Tüzen, 2004, Food Chemistry, 86, 547-552.

219

PO-88 Characterization of Nano Silver Particles which are bonded with Sol- Gel Method to

Activated Carbon

Esra ALTINTIG, Omer Faruk SOYDAN, Sule KIRKIL, Huseyin ALTUNDAG Department of Chemistry, Faculty of Art and Science,Sakarya University, TR-54187, Sakarya, Turkey

Abstract: Activated carbons are materials that are not characterized with any structural formula or chemical analysis and are composed by carbon atoms with high porosity and internal surface structure. Activated carbons which have very good adsorbent are being used in various areas in the industry[1, 2]. Activated carbon which includes oxygen is activated with sol - gel method. Activated active carbon Nano-composites with well-dispersed silver nanoparticles (Ag-AC) were prepared by addition of Ag + on the functionalized Ac surface via ion dipole interactions and subsequent in-stu reduction of Ag+ [3]. Microstructure and surface morphologies of covered Ag-AC nano-composites are examined with SEM. Silver amount in Ag-AC samples are determined with Atomic Adsorption Spectroscopy. It is determined with X-ray diffraction that the crystals are sharper when the silver amount which is bonded to activated carbon is increased.

*Thisstudy is supportedby a grant (Project Number:2014-02-04-009) fromScientificResearchProjectsCommitteeof Sakarya University.

References

1. H. Hadoun, Z. Sadaoni, N.Souami, D.Shel, I.Toumert, 2013, Applied Surface Science, 280, 1-7. 2.G.J.Poinern, G.Senanayake, N.Shah, X.N.Thie-Le, G.M.Parkinson, D. Fawcett, 2011, Minerals

Engineering, 24, 1694-1702. 3. L. Pei, J. Zhou, L. Zhang, 2013, Building and Environment, 63, 108-113.

220

PO-89 Derivative Spectrophotometric Determination of Ascorbic Acid and

N-Acetylcysteine*

Merve AYHANa, Aysel KÜÇÜK TUNCAa

aDepartment of Chemistry, Faculty of Art and Science,Sakarya University, TR-54187, Sakarya, Turkey Abstract: Vitamin C (ascorbic acid, ascorbate) (AA) is a water-soluble organic compound involved in many biological processes [1]. N-Acetylcysteine (NAC) is mainly used as a mucolytic agent in bronchitis or pulmonary diseases [2]. In this study, first order derivative UV spectrophotometric method was developed and validated for simultaneous determining AA and NAC in combined pharmaceutical dosage preparations. All first derivative spectra of AA and NAC were recorded respectively at 222,5 and 280 nm with spectral bandwith of 2 nm in wavelenght range of 190 and 450 nm. The linearity ranges of AA and NAC were observed to be 3-60 µg mL-1 and 6-84 µg mL-1. This method was applied to without any pre-treatment of all samples and validated in according to ICH guidelines [3].It was obtained high recovery values thanks to this derivative spectrophotometric method. This developed UV derivative method has been simple, accurate, sensitive and lineer and can be easily applied directly to the quality control analysies of pharmaceutical dosage forms containing AA and NAC. The spectrophotometric method is the first study in the literature for determiningof combined two active ingredients.

Scheme1.Structural formulas of Ascorbic Acid and N-Acetylcysteine

*This study is supported by a grant (Project Number: FBYLTEZ 2013-50-02-025) from Scientific Research Projects Committeeof Sakarya University.

References

1. S. S. Mitić, D. A. Kostić, D. C. Nasković-Ðokić, M. N. Mitić, Tropical Journal of Pharmaceutical Research, February 2011, 10 (1), 105-111. 2. S. Sana, Dr. A. Rajani, Dr. N. Sumedhab, P. Pravin and Dr. N. Shripad, Int. J. Drug Dev.& Res., April-June 2012, 4(2), 284-293. 3. ICH,Validation of Analytical Procedures: Text and Methodology, Step 4 Version, 2005.

221

PO-90 Total Phenolics, Total Flavonoids and Cupric Ion Reducing Antioxidant Capacity of

Broad-leaf Dock (Rumex obtusifolius) Plant Esma Hande ALICIa, Gulnur ARABACIa

aDepartment of Chemistry, Faculty of Art and Science, Sakarya University, TR-54187, Sakarya, Turkey Abstract: Antioxidants are compounds or systems that can safely interact with free radicals and delay, control, or prevent the oxidative chain reaction before vital molecules are damaged. Antioxidants have various biological properties, such as anti-inflammatory, anti-carcinogenic and anti-atherosclerotic effects reduce the incidence of coronary diseases. Polyphenolic compounds that have antioxidant and free radical-scavenging abilities are ubiquitous in all plant organs and are, therefore, an integral part of the human diet [1]. Rumex obtusifolius L. (Polygonaceae) is one of the most common plants that occur in silage fields, on river banks and in ditches. It grows in Northern Ireland, Africa, temperate Asia, and Europe. This perennial and dietary plant has long been used in folklore medicine as an antidote to nettle, depurative, astringent, laxative, and tonic, and in the treatment of sores, blisters, burns, cancer and tumors [2]. In this study, we determined the antioxidant activity of two different solvent fractions (methanol and ethyl acetate) obtained from Rumex obtusifolius L. plant leaves by using different antioxidant methods (Folin-Ciocaltaeu[3], Aluminum Nitrate [4] and CUPRAC (Cupric Ion Reducing Antioxidant Capacity) [5]). The total phenolic content of the organic solvent extract of Broad-leaf Dock( Rumex obtusifolius L.) leaves was determined using the Folin-Ciocalteau assay. Total flavonoid content of the plant extract was measured by using aluminum chloride colorimetric assay. Our results showed that this edible plant (Rumex obtusifolius L.) has high antioxidant capacity.

References

1. M. Oroian, P. Escriche, Food Res. Int.,2015, 74, 10-36. 2. D. Harshaw, L. Nahar, B. Vadla, G. M. Saif-E-Naser, S. D. Sarker,A.B.S., 2004, 62 (2), 387-392. 3. N. Gamez-Meza, J. A. Noriega-Rodriguez, L. A. Medina-Juarez,J. Ortega-Garcia,R. Cazarez-Casanova,

O. Anguloguerrero, J.A.O.C.S.,1999,76, 1445. 4. M. Moreno, M. I. Isla, A. R. Sampietro,M. A. Vattuone,J Ethnopharmacol.,2000, 71, 109-114. 5. K. Güçlü, M. Altun, M. Özyürek, S. E. Karademir, R. Apak, Int. J. Food Sci. Tech.,2006, 41, 76-85.

222

PO-91 Enzymatic Bio-Bleaching of Cotton/PA Fabric *

Ayse USLUOGLUa, Gulnur ARABACIa aDepartment of Chemistry, Faculty of Art and Science,Sakarya University, TR-54187, Sakarya, Turkey

Abstract:

The use of enzymes to substitute conventional chemicals in the textile industry is rapidly gaining interest because of their non-toxic and eco-friendly characteristics to reduce pollution in the textile industry. Furthermore, the use of enzymes results in reduced process times, energy and water savings, the improved product quality and the potential process integration [1]. Previous studies show that tetraacetyl ethylenediamine (TAED) with peroxide system has potential in the bleaching of cotton-based fabrics with improved bleaching effectiveness under mild conditions [2]. The present work aims to optimize the bleaching process parameters including TAED and H2O2 concentrations, time, pH, temperature and to compare the bleaching process using TAED and H2O2 with TAED, H2O2 and enzyme combination in the same bath. Quality of bleached cotton /PA fabric was measured in terms of whiteness index, tensile strength, fabric absorbency. The optimum bleaching recipe consisted of 15 g/L, TAED; 5 g/L, hydrogen peroxide; 3 g/L, enzymes and 1 g/L non-ionic wetting agent, the treatment was carried out at 60°C for 60 min. The optimized bleaching recipe and processing were compared with conventional process. Results obtained that, Cotton/Polyamide fabric bleached with TAED/H2O2 and either protease or pectinase enzyme shows excellent wettability and acceptable whiteness index (WI). This bio-process achieved equal quality cotton/PA fabric whiteness to the conventional system at much shorter batch times, and with significantly reduced fabric strange lost and alkali consumption that would be beneficial to the textile industry.

*This study is supported by a grant (Project Number: FBDTEZ, 2011-50-02-021) from Scientific Research Projects Committeeof

Sakarya University.

References

1. N. Durh and M. Durh, Rev. Proc. Coloration, 2000, 30, 41-44. S. 2. S. Scarborough and A. Mathews,Text. Chem. Color. Am. D.,2000, 32-3, 33-37.

223

PO-92 Anionic Dye Removal using Polymer Inclusion Membrane (PIMs)

Ozlem DEMIRBASa, Havva POLATa, Yasemin YILDIZb, Murat TEKERa,

Aynur MANZAKa

aDepartment of Chemistry, Faculty of Art and Science,Sakarya University, TR-54187, Sakarya, Turkey bVocational School of Health Services, Sakarya University, TR-54100,Sakarya, Turkey

Abstract:

Dyes are widely used in various industries, such as textiles, paper, plastics, cosmetics and leather, for colouring their final products.Colour is the first contaminant to be recognized in wastewater. Membrane separation is a relatively new type of separation process, which is predicted ultimately to replace a majority of the conventional separation systems. In this study, we carried out to remove an acid dye (Red Erionyl A-3B) from their aqueous solutions using polymer inclusion membranes (PIMs) consisting of poly-vinylchloride (PVC)as the base polymer,2-Nitrophenyl pentylether (2-NPPE) as the plasticizer, trioctylmethylammoniumchloride (Aliquat 336) as carrier and tributylphosphate (TBP) as a modifier. Extraction efficiency was studied under various experimental conditions, such as initial dye concentration, stirring speed and pH values. Consequently, a simple, cost effective and safe alternative for colour removal of dyes from aqueous solution is achieved.

References

1. J. X. Lin, S. L. Zhan, M. H. Fang, X. Q. Qian, H. Yang, J. Environ. Manage., 2008, 87, 193-200. 2. G. Crini, Bioresour. Technol.,2006, 97,1061-1085. 3. A. Salima, K.S. Qunissa, M. Lynda, B. Mohamed, Procedia Eng., 2012, 33, 38-46.

224

PO-93 Application of Polymer Inclusion Membranes (PIMs) Including

Aliquate 336 for the Extraction of Humic Acid

Cem KURSUNa, Yasemin YILDIZb, Aynur Manzaka, Abdil OZDEMIRa,Ahmet TUTARa

aDepartment of Chemistry, Faculty of Art and Science,Sakarya University, TR-54187, Sakarya, Turkey bVocational School of Health Services, Sakarya University, TR-54100,Sakarya, Turkey

Abstract:

Humic acids (HA) are one of the major components of humic substance. The presence of humic substances in water introduces a yellowish to brown color. Highy affinity of humic substances for complexation with various pollutants including heavy metals and pesticides causes contamination of ground and surface water.Membrane separation is a relatively new type of separation process, which is predicted ultimately to replace a majority of the conventional separation systems. In this study, we carried out to remove an humic acid from their aqueous solutions using polymer inclusion membranes (PIMs) consisting of Cellulose triacetate (CTA)as the base polymer,2-Nitrophenyl pentylether (2-NPPE) as the plasticizer, trioctylmethylammoniumchloride (Aliquat 336) as carrier and tributylphosphate (TBP) as amodifier. Extraction efficiency was studied under various experimental conditions, such as initial humic acid concentration, stirring speed and stripping solution type.

References

1. A. Imyim, E. Prapalimrungsi, J. Hazard. Mater.,2010,184, 775-781. 2. R. Artinger, G. Buckau, S. Geyer, P. Fritz, M. Wolf, J. I. Kim, Appl. Geochem.,2000, 15, 97-116.

225

PO-94 Speciation of Heavy Metals in food samples by Ultrasonic Supported Sequential

Extraction Method and Microwave Leaching in using ICP-OES

Hüseyin ALTUNDAG1, Muhammet YILMAZ1, Asude ATES2 1Department of Chemistry, Faculty of Art and Science,Sakarya University, TR-54187, Sakarya, Turkey

2Department of Environmental Chemistry, Faculty of Engineering,Sakarya University, TR-54187, Sakarya, Turkey

Abstract: In this study, the suitability of ultrasonic effect on commonly used BCR (Community Bureau of the European Commission) procedure has been investigated in food samples. Copper and Zinc levels in food samples, which found with UBCR procedure, were also detected by analysis with microwave methods. Besides providing data about the total amount of heavy metals in soils, sediments and foods, BCR procedure also let information about specific chemical forms of metals. However, in this procedure each step takes about 16 hours. It is assumed that using ultrasonic supported sequential extraction methods instead of mechanical agitation can also provide information about chemical forms of food samples [1,2]. The validity of the analytical procedure was checked by analysing INCT-TL-1 CRM and DORM-3 (Fish Protein Certified Reference Material for Trace Metals) certified reference materials. The obtained results will be presented in 1st International Turkic World Conference on Chemical Sciences and Technologies (ITWCCST).

References

1. E. Bağda, 2006, Sediment Örneklerinin Ultrasonik Destekli Ardışık Ekstraksiyon ve Mikrodalga Çözündürme Yöntemleri İle Kimyasal Analize Hazırlanması, Yüksek Lisans Tezi, Cumhuriyet Üniversitesi, Kimya Anabilim Dalı, Sivas.

2. H. Altundag, M.S. Dundar, S. Doganci, M. Celik, M. Tuzen, 2013, The Use of a Sequential Extraction Procedure for Heavy Metal Analysis of House Dusts by Atomic Absorption Spectrometry, Journal of AOAC International, 96 (1), 166-170.

226

PO-95 Synthesis, Characterization, Photophysical and Electrochemical Properties of 4,4-Fluoro-

8-ethyl-3,5-bis(4-ethylphenyl)-4-bora-3a,4a-diaza-s-indancene (BODIPY)*

Raşit Fikret YILMAZ, İbrahim Halil BAYDİLEK, Ömer Faruk TUTAR, Yavuz DERİN, Ahmet TUTAR Department of Chemistry, Faculty of Art and Science,Sakarya University, TR-54187, Sakarya, Turkey

[email protected] Abstract: 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) dyes have attracted much attention due to the excellent applications in many areas such as fluorescent switches, supramolecular polymers, labelling reagents, chemosensors, photodynamic therapy, choromogenic probes, laser dyes, and sensitizers for solar cell applications. BODIPY dyes tend to be strongly UV-aborbing small molecules that emit relatively sharp fluorescence peaks with high quantum yields. These dyes are widely used to label proteins and DNA.1,2

Scheme. Synthesis of BODIPY from Pyrrole

In this study, we report the synthesis of a new BODIPY compound in reasonable yield according to literature (Scheme).3 The structure of synthesised BODIPY is identified by spectroscopic techniques, including 1H NMR, 13C NMR, IR, Mass and elemental analysis. The electrochemical properties of BODIPY were investigated by cyclic voltammetry in CHC3CN at a scan rate of 100 mV/s using tetrabutylammoniumhexafluorophosphate as supporting electrolyte. Photophysical properties of BODIPY were studied by using absorption and emission spectroscopy in dichloromethane. *This study is supported by the Scientific and Technological Council of Turkey (TÜBİTAK, KBAG-114Z176) and the Scientific Research

Projects Unitof Sakarya University (BAP-2014-02-04-010).

References

1. Goud, T.V., Tutar, A., Biellmann, J.F. Tetrahedron, 2006, 62, 5084-5091. 2. Tutar, A., Erenler, R., Biellmann, J.F. J. Chem. Soc. Pak. 2013, 35 (4), 1197-1201. 3. Lee, P.H., Bull. Korean Chem. Soc. 2008, 29 (1), 261-264.


227

PO-96

Synthesis, Characterization, Photophysical and Electrochemical Properties of 4,4-Fluoro-8-(4-bromophenyl)-3,5-bis(4-trifluoromethoxyphenyl)-4-bora-3a,4a-diaza-s-indancene

(BODIPY)* Raşit Fikret YILMAZa, İbrahim Halil BAYDİLEKa, Ömer Faruk TUTARa, Salih ÖKTENb, Ahmet TUTARa

aDepartment of Chemistry, Faculty of Art and Science,Sakarya University, TR-54187, Sakarya, Turkey bDepartment of Primary Education, Division of Science Education, Faculty of Education, Kırıkkale University,TR-71450,

Kırıkkale,Turkey

[email protected] Abstract: 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) dyes have attracted much attention due to the excellent applications in many areas such as fluorescent switches, supramolecular polymers, labelling reagents, chemosensors, photodynamic therapy, choromogenic probes, laser dyes, and sensitizers for solar cell applications. BODIPY dyes tend to be strongly UV-aborbing small molecules that emit relatively sharp fluorescence peaks with high quantum yields. These dyes are widely used to label proteins and DNA.1,2

Scheme.Synthesis of BODIPY from Pyrrole

In this study, we report the synthesis of a new BODIPY compound in reasonable yield according to literature (Scheme).3 The structure of synthesised BODIPY is identified by spectroscopic techniques, including 1H NMR, 13C NMR, IR, Mass and elemental analysis. The electrochemical properties of BODIPY were investigated by cyclic voltammetry in CHC3CN at a scan rate of 100 mV/s using tetrabutylammoniumhexafluorophosphate as supporting electrolyte. Photophysical properties of BODIPY were studied by using absorption and emission spectroscopy in dichloromethane. *This study is supported by the Scientific and Technological Council of Turkey (TÜBİTAK, KBAG-114Z176) and the Scientific Research


References

1. Goud, T.V., Tutar, A., Biellmann, J.F. Tetrahedron, 2006, 62, 5084-5091. 2. Tutar, A., Erenler, R., Biellmann, J.F. J. Chem. Soc. Pak. 2013, 35 (4), 1197-1201. 3. Lee, P.H., Bull. Korean Chem. Soc. 2008, 29 (1), 261-264.


228

PO-97

A Facile and Efficient Synthesis of 5-Bromo-2,2-dihydroxy-1,3-indandione (5-Bromoninhydrin) From Indane*

Raşit Fikret YILMAZ, İbrahim Halil BAYDİLEK, Ömer Faruk TUTAR, Ahmet TUTAR

Department of Chemistry, Faculty of Art and Science,Sakarya University, TR-54187, Sakarya, Turkey [email protected]

Abstract: Ninhydrin (2,2-dihydroxyinden-1,2-dione) is well-known in particular owing to its color forming reaction with amins. Due to this property, numerous ninhydrin derivatives and analogues1 have been reported for their use as latent fingerprint dedectors in forensic science. Ninhydrins are of increasing interest in photochemistry and versatile intermediates in the synthesis of heterocyclic compounds, highly substituted imidazol, and substituted furans.2 Aryl bromides are precursors to numerous organometallic species that are used in organic synthesis. Bromoninhydrin is important precursors for synthesis of ninhydrin derivatives and analogues. Bromoninhydrins are usually prepared by oxidation of indan-1-ones which are very expensive starting material.3

Scheme.Synthesis of 5-bromoninhydrin starting from indane

In a previous article, we reported the facile synthesis of pentabromaindane by photochemical brominatinon starting from indane.4 In this work, we report a facile and highly efficient method fort he synthesis of 5-bromoninhydrin starting from indane which is very cheap and commercially available starting material. Four step process involved ionic bromination of the indane, photochemical bromination of 5-bromoindane, silver-supported hydrolysis of hexabromoindane, and, finally, oxidation of bromoketons with DMSO (Scheme). *This study is supported by the Scientific and Technological Council of Turkey (TÜBİTAK, KBAG-114Z176) and the Scientific Research


References

1. Hansen, D.B., Joullie, M.M. Chem. Soc. Rev., 2005, 34, 408-417. 2. Tatsugi, J. And Izawa Y. Synt. Commun., 1998, 28 (5), 859-864. 3. Hark, R.R., Houze, D.B., Petrovskaia, O.,Joullie M.M. Can. J. Chem. 2001, 79, 1632-1634. 4. Tutar, A., Çakmak O., Balcı, M. Tetrahedron 2001, 57, 9759-9763.


229

PO-98 Synthesis and Antimicrobial Activities of New Conazole and Fluoroquinolones

Neslihan Demirbasa, Serap Basoglua, Yıldız Uyguna, Arif Mermera, Ahmet Demirbasa, Serpil Demircib, Sule

Ceylanc aKaradeniz Technical University, Institute of Science, Trabzon, TURKEY

bGiresun University, School of Applied Science, Department of Crop Production and Technology, Giresun, TURKEY cArtvin Coruh University, Department of Occupational Health and Safety, Artvin, TURKEY

[email protected]

In recent years, life threatening systemic fungal infections has become increasingly common, especially in the immune compromised hosts suffering from tuberculosis, cancer or AIDS and in organ transplant cases [1]. 1,2,4-Triazole ring is known as versatile lead molecule for designing potential bioactive structures. Its derivatives have been incorporated into a wide variety of therapeutically important activities including antibacterial anti-inflammatory, CNS depressant, anti-tubercular anti-HIV [2]. In recent years, Mannich bases have gained importance due to their application in pharmaceutical chemistry. They have been found to possess antibacterial, antifungal, anticancer [3], antitubercular [4], analgesic and anti-inflammatory properties. Keeping this observation in view and in continuation of our study on the synthesis of biologically active compounds along with their antimicrobial activities, we obtained new piperazine compounds in the conazole structure beside the compounds containing fluroquinolone nucleus.

i

ii

iii

iv

v

vi

vii

N NO

O

NHN

N S

N NO

O

NN

N S

N NO

O

NN

N S

N N

N

OO

OH

F

N NO

O

NN

N S

N N

N

OO

OH

F

N NO

O

NN

N S

NH

N

S

COOHO

N NO

O

NN

N S

NH

N

S

O

COOH

OAc

viii

ix

O

Cl

N NO

O

NN

N SOH

Cl

N NO

O

NN

N SO

Cl

Cl

N NO

O

NN

N SO

Cl

Cl

Cl

N NO

O

NN

N SO

Cl

Cl

Cl

Scheme 1.i: 6-aminopenicillanic acid, HCHO, ii: 7-aminocephalosporanic acid, HCHO, iii: norfloxacin, HCHO, iv: ciprofloxacin, v: 2-bromo-4' -chloroacetophenone vi: NaBH4, vii:NaH, 2,4-dichlorobenzyl chloride, viii: NaH, 2,6-dichlorobenzyl chlorideix:NaH, 4-chlorobenzyl chloride

References

1. Fridkin, S.K. Jarvis,W.R. Clin. Microbiol. Rev. 1996, 9, 499. 2. Bayrak, H. Demirbas, N. Demirbas, A. Karaoglu,S .A. Eur.J. Med. Chem. 2010, 45, 4726. 3. Holla, B.S. Poojary, K.N. Sooryanarayana B. Shivananda, M.K. Eur. J. Med. Chem. 2002, 37 511. 4. Walczak, K. Gondela, A. Suwin´ ski J, Eur. J. Med. Chem. 2004, 39, 849.


230

PO-99 Synthesise of Isoxazole and Dehydro Isoxazole from Chalcones

Nurettin Yaylıa, Seda Fandaklıb, and Büşra Yaylıa aDepartment of Pharmacognosy, Faculty of Pharmacy,Karadeniz Technical University, Trabzon-TURKEY,

bDepartment of Chemistry, Faculty of Science, Karadeniz Technical University, Trabzon-TURKEY

Abstract:

Isoxazole is an heterocyclic compounds with an oxygen atom next to the nitrogen and found in some natural products (ibotenic acid) and used as drugs (valdecoxib (Bextra), furoxan, dicloxacillin, cloxacillinand flucloxacillin). The isoxazole ring containing molecule exhibit various biological activity such as antifungal, antimicrobial, anticancer, analgesic, antiinflammatory, antituberculine, antiviral, antipsychotic, and hypoglycemic activities1.

In this study, we synthesized four aryl substituted isoxazole (5,6,9,10) and four 4,5-dehydro isoxazole compounds (7,8,11,12) starting from methoxy substituted azachalcones (1-4) with hydroxyl amine hydrochloride2,3(Figure). Synthetic compounds (1-12) are characterized by spectral data (1H/13C NMR, IR, and LC-MS/MS).Biological activities of synthetic compounds are under evaluation.

OR1

R2

R3N

NaOH

Ethanol, reflux

R1

R2

R3

N O R1

R2

R3

N O

R2

R3

R1 N O

R2

R3

R1 N O

N

N N

N

%38 52 %

%34 56%

5-6 7-8

9-10 11 12-

1 - 4

, + +NH2OH.HCI

Figure

References

1-S. Khanage, P. Mohite, R. Pandhare, A. Raju, Marmara Pharmaceutical Journey, 2012,16:134-140. 2-A. K. Ahirvar, From Journal of the Institution of Chemists, 2007, 79 (5), 146-151. 3-A.L.Baumstark, T. Dunams, Journal of Heterocyclic Chemistry, 1981, 18 (6), 1113-16.

-R1 -R2 -R3

1, 5, 7 : -OCH3 -H -H 2, 6, 8 : -H -OCH3 -H 3, 9, 11 : -H -OCH3 -H 4,10, 12 : -H -H -OCH3

https://en.wikipedia.org/wiki/Ibotenic_acid

https://en.wikipedia.org/wiki/Valdecoxib

https://en.wikipedia.org/wiki/Bextra

https://en.wikipedia.org/wiki/Furoxan

https://en.wikipedia.org/wiki/Dicloxacillin

https://en.wikipedia.org/wiki/Cloxacillin

https://en.wikipedia.org/wiki/Flucloxacillin

231

PO-100 Synthesis And Antimicrobial Activity of Triazole Containing Azole Derivates

Arif Mermer,Yıldız Uygun, Serpil Demirci, Serap Basoglu, Ahmet Demirbas, Neslihan Demirbas, Serdar Ulker

1Karadeniz Technical University, Department of Chemistry, 61080 Trabzon 2Recep Tayyip Erdogan University, Department of Biology, 53000 Rize

[email protected]

Abstract: The incidence of systemic fungal infections has been increasing dramatically due to an increase in the number of immunocompromised hosts, such as patients undergoing anticancer chemotherapy or organ transplants and patients with AIDS1. In contrast to the large number of antibacterial antibiotics, there are very few antifungal agents that can be used for life-threatening fungal infections. These drugs are amphotericin B, 5-fluorocytosine, azoles (such as fluconazole and itraconazole), and echinocandins (such as caspofungin and micafungin). Because of their high therapeutic index, azoles are first-line drugs for the treatment of invasive fungal infections. Unfortunately, the broad use of azoles has led to development of severe resistance,5,6 which significantly reduced the efficacy of them. This situation has led to an ongoing search for new azoles. Several novel triazole antifungal agents, such as voriconazole, posaconazole, ravuconazole and albaconazole, are marketed or currently in the late stages of clinical trials2.In this study, some hybrid compounds have been obtained containing basic structure of conazole nucleus and their biological activities have been studied.

i: BrCH2CO2Et, ii: H2NNH2, iii: RNCS, iv: NaOH, v: 2,4-Cl2C6H3COCH2Cl, vi: NaBH4, vii: NaH and 2,4-dichlorobenzyl chloride, viii: HCHO, CIP

NN

N SHNN

OCH3

i, ii, iii, iv

1 2

NN

N SNN

OCH3O

R3

R2

ClCl

R1

v,vi

vii

N NH

OCH3

3

NN

N SNN

OCH3

N

NN

O

OH

O

F

4

viii

NN

N SNN

OCH3OH

ClCl

2,6-dicholorobenzyl chloride 4-chlorobenzyl chloride

5= R1: H, R2: Cl, R3: Cl6= R1: H, R2: Cl, R3: H7= R1: Cl, R2: H, R3: Cl

Figure 1. Proposed reaction mechanism of compound 5, 6, 7

References

1. Fridkin, S. K.; Jarvis, W. R. Clin. Microbiol. Rev. 1996, 9, 499. 2. Wenya Wang, Chunquan Sheng, Xiaoying Che, Haitao Ji, Yongbing Cao, Zhenyuan Miao; Bioorg.

Med. Chem. Lett. 2009, 19, 5965–5969.

Acknowledgment This study is supported by Turkish TUBITAK program (Project number 113Z181)


232

PO-101 SynthesisandCharacterization of New Triazole-SubstitutedCoumarin Derivatives

Nurhan GÜMRÜKÇÜOĞLU Vocational School of HealthSciences, Karadeniz Technical University, TR-61080, Trabzon, Turkey

E-Mail : [email protected] Abstract: Substituted1,2,4-triazoles areamongthelargenumber of heterocycliccompoundsthathavereceivedthemostattentionduringthelasttwodecades as potentialantimicrobialagents. Theyareassociatedwithdiversebiologicalactivitiessuch as fungicidal, antimicrobial, antiviralactivitiesetc.[1].The1,2,4-triazole nucleus has beenincorporatedinto a widevariety of therapeuticallyinterestingdrugs, including H1/H2 histaminereceptorblockers,Cholinesterase- activeagents, CNS stimulants, antianxietyagentsandsedatives[2]. Coumarinsarenowadays an importantgroup of organiccompoundsthatareused as additivestofoodandcosmetics, opticalbrighteningagentsanddispersedputrescentandlaserdyes[3]. Thederivatives of coumarinusuallyoccur as secondarymetabolitespresent in seeds, rootsandleaves of manyplantspecies. Theirfunction is far fromclear, thoughsuggestionsincludewasteproducts, plantgrowthregulators, fungistatsandbacteriostats.

1 2 3 4

Scheme 1.Synthesized heterocyclic compounds. Owing to the widespread applications, synthetic and biological activity evaluation of coumarins and their derivatives has been a subject of intense investigations. In this study, it has been synthesized and characterized some newtriazole-coumarinderived heterocyclic compounds (1-4). References 1. N. Gumrukcuoglu, S. Ugras, H. I. Ugras, U. Cakir, J.Incl.PhenomMacrocycl.Chem.,2012, 73, 359. 2. N. Gumrukcuoglu, B.Bilgin Sokmen, S. Ugras, H.I. Ugras, R. Yanardag, J. EnzymeInhib. Med. Chem.,2013,

28, 89. 3. A. Mohsen, M.E. Omarand A. Wafa, J. Heterocycl. Chem.,1986, 23,1339.

233

PO-102 Synthesis and Characterization of Novel Heterocyclic Compounds by Reacting Bis

Coumarins and Triazole Derivatives

Nurhan GÜMRÜKÇÜOĞLU Vocational School of Health Sciences, Karadeniz Technical University, TR-61080, Trabzon, Turkey

E-Mail : [email protected] Abstract : Heterocycles including amino group can be considered as useful intermediates in organic synthesis. The amino group is ready-made nucleophilic center for the synthesis of condensed heterocyclic ring[1]. Coumarins are used as sweetener, fixative of perfumes, enhancer of natural oils such as lavender, a food additive in combination with vanillin, a flavour/odour stabilizer in tobacco, an odour masker in paints and rubber [2].

1 2 3 4

Scheme 1.Synthesized heterocyclic compounds.

The main purpose of this research work has been to synthesize some new Schiff bases to utilize as ligands and to study the ligands and their metal complexes from a structural point of view. These ligands with a variety of bonding interactions, tautomeric phenomena, potential variety of bonding modes and hydrogen bonding interactions, were expected to provide stimulating results. In this study, it has been synthesized some new triazole and coumarin-derived heterocyclic compounds (1-4). References 1) N. Gumrukcuoglu, B. Bilgin Sokmen, S. Ugras, H. I. Ugras, R. Yanardag, J. Enzyme Inhib. Med. Chem., 2013,

28, 89. 2) Y. K. Tyagi, A. Kumar, H. G. Raj, P. Vohra, G. Gupta, R. Kumari, P. Kumar, Eur J Med Chem.,2005, 40, 413.

234

PO-103 Synthesis of New Triazol Derivatives Containing Several Pharmacophore Groups and

Investigation of Their Antimicrobial Activities

Ahmet Demirbasa, Yıldız Uyguna, Serap Basoglua, Arif Mermera, Hacer Bayraka,Sule Ceylanb, Neslihan Demirbasa

a)Karadeniz Technical University, Department of Chemistry, 61080, Trabzon, Turkey

b)Artvin Coruh University, Department of Forest Industrial Engineering, Artvin, Turkey email: [email protected]

Syntheses of compounds incorporating five membered heterocyclic rings have been attractinginterest

over the past decade because of their use in various applications, such as propellants, explosives, pyrotechnics and especially chemotherapy (1, 2). In the field of medicinal chemistry, azoles are widely used and studied class of antimicrobial agents due to their safety profile and high therapeutic index. Among azole-based drugs, Conazoles such as Itraconazole, Fluconazole, Voriconazole and Ravuconazole constitute a major class being used for the treatment fungal infections(3).In the present study, the synthesis and antimicrobial screening of new thiadiazole derivatives incorporating different pharmacophores as hybrid molecules possessing antimicrobial activity were aimed. All the newly synthesized compounds displayed IR, 1H NMR, 13C NMR, mass spectral data, and good antimicrobial activity results.

N

NHN

O

N

N

H

i, ii, iiiN

NN

O

N

N

O

NHNH NH

X

H1

2:X=S; 3:X=O

v N

NN

O

N

N

N

NHN

X

H

4:X=S; 5:X=O

N

NN

O

N

N

N

NN

X

R

H

6a: X=S, R= 7a: X=O, R= 7b: X=O, R =

iv

6, 7

N

O

COOHF

N

N

N

O

COOHF

N

N6b: X=S, R =

N

O

COOHF

N

N

N

O

COOHF

N

N

i:BrCH2CO2Et, ii:H2NNH2,iii:PhNCX, iv:NaOH, v: HCHO and amine 1. Ozyanık, M. Demirci, S. Bektas, H. Demirbas, N. Demirbas, A. Karaoglu, S.Turk J Chem.2012, 2. Basoglu, S. Yolal, M. Demirbas, A. Bektas, H. Abbasoglu, R. Demirbas, N. Turk J Chem. 2012, 36: 37-53. 3. Gupta, A., Unadkat, JD. Mao, Q. J Pharm Sci . 2007, 96: 3226–3235. *This Study is supported by a grant 113Z181 from TUBİTAK


235

PO-104 Synthesis and Characterization of Some New Conazole Derived from Ethyl Piperazine

Nucleus Serap Basoglua, Yıldız Uyguna, Hacer Bayraka, Neslihan Demirbasa, Arif Mermera, Ahmet Demirbasa, Sule

Ceylanb aKaradeniz Technical University, Institute of Science, Trabzon, TURKEY

bArtvin Coruh University, Department of Occupational Health and Safety, Artvin, TURKEY [email protected]

Abstract :

During the past two decades, fungal infection has become animportant complication and a major cause of morbidity andmortality in immunocompromised individuals such as patientsundergoing anticancer chemotherapy or organ transplants andpatients with AIDS [1]. There are a number of antimicrobialcompounds containing a 1,2,4-triazole ring in their structures suchas Fluconazole, Itraconazole, Voriconazole, Ravuconazole and Posaconazolethat are important antifungal drugs [2]. In the present study, a series of new azoles with substituted ethyl piperazine side chains were designed and synthesized as antimicrobial agents.

N NO

O

NN

N

N N

O

NH

HN

O

OS

NH

i,ii

iii

iv v vi

S

N NO

O

NN

N SOH

Cl

N NO

O

NN

N SO

Cl

N NO

O

NN

N SO

Cl

Cl

N NO

O

NN

N SO

Cl

ClCl

Cl Cl

O

Cl

Scheme 1.i: NaOH ii: 2-bromo-4' -chloroacetophenone , iii: NaBH4, iv: NaH, 2,6-dichlorobenzyl chloride v: NaH, 4-chlorobenzyl chloride vi: NaH, 2,4-dichlorobenzyl chloride

*This study is supported by a grant 113Z181 from TÜBİTAK. References [1] Fridkin, S.K. Jarvis,W.R. Clin. Microbiol. Rev. 1996, 9, 499. [2] Bayrak, H. Demirbas, N. Demirbas, A. Karaoglu,S.A. Eur.J. Med. Chem . 2009, 44, 4362-4366.

236

PO-105 Synthesis and Antimicrobial Activity Evaluation of New Fluoroquinolone Derivatives

Starting from Triptamine

Yıldız Uyguna, Serap Basoglua, Arif Mermera, Hacer Bayraka, Sule Ceylanb, Ahmet Demirbasa, Neslian Demirbasa, Serdar Ulkerc

a)Karadeniz Technical University, Department of Chemistry, 61080, Trabzon,Turkey

b)Artvin Coruh University, Department of Occupational Helath And Safety, Artvin, Turkey c) Recep Tayyip Erdogan University, Department of Biology, 53100, Rize, Turkey

email: [email protected]

Multicomponent reactions constitute an important method for organic synthesis with advantages ranging from lower reaction times, increased reaction rates to higher yields and reproducibility [1]. Mannich reaction is a three-component condensation reaction involving active hydrogen containing compound, formaldehyde and a primary or secondary amine.This reaction provides a method for the introduction of basic aminoalkyl chain into a molecule. Several drugs obtained by Mannich reaction are proved to be more effective and less toxic than the parent antibiotic.The amino alkylation of aromatic substrates by Mannich reaction has considerable importance for optimization of drug discovery processes [2-4]. In continuation of our research program on the synthesis of hybrid molecules containing various heterocyclic moieties, we planned the synthesis of some mannich bases derivatives along with their antimicrobial activities.

NH

NH2

NH

NH O

O

NH

NH

O

NHNH2

iii

iii,iv

NH

NH

O

NHNH NH

X

v

NH

NH N

NHN

X

NH

NH N

NN

X

R

3 2 1

6: X=S7: X=O4: X=S

5: X=O

i:BrCH2CO2Et, ii:H2NNH2,iii:PhNCS, iv:PhNCO,v:NaOH, vi: HCHO and amine

6a: X=S, R= 7a: X=O, R= 7b: X=O, R =

N

O

COOHF

N

N

N

O

COOHF

N

N6b: X=S, R =

N

O

COOHF

N

N

N

O

COOHF

N

N

vi

References 1. A. Demirbas, D. Sahin, N. Demirbas, S. A. Karaoglu Eur.J.Med.Chem 44, 2896-2903 (2009). 2. S. Joshi, N. Khosla, D. Khare R. Sharda, Bioorg. Med. Chem. Lett. 15 ,221–226. (2005). 3. R.E. Dolle, K.H. Nelson, J. Comb. Chem. 1, 235 (1999). 4. M.S.A. El-Gaby, G. A.M. El-Hag Ali A.A. El-Maghraby, M.T. Abd El-Rahman, M.H.M. Helal, Eur.J. Med. Chem. 44, 4148–4152 (2009).

*This Study is supported by a grant 113Z181 from TUBİTAK


237

PO-106 Synthesis and Antimicrobial Activities of Novel Conazoles with Triazol Ring

Arif MERMER1, Yıldız Uygun1, Serpil Demirci, Serap Basoglu1, Neslihan Demirbas1, Serdar Ulker2

1Karadeniz Technical University, Department of Chemistry, 61080 Trabzon

2Recep Tayyip Erdogan University, Department of Biology, 53000 Rize

[email protected] Abstract: In recent years, life-threatening systemic fungal infections have become increasingly common in the immunocompromised hosts suffering from cancer, AIDS, and other diseases, or in organ-transplant patients Currently, there are three major clinical fungal infections caused by Candidosis, aspergillosis, and cryptococcosis, respectively. Several clinical drugs, including azoles such as fluconazole, voriconazole and itraconazole polyenes such as amphotericin B have been developed to reduce the impact of fungal diseases. Among those antifungal drugs, azoles, especially triazole agents such as fluconazole, voriconazole and itraconazole, are proved to be more effective and thus are more widely used for the treatment of invasive fungal infections. So, in this study some hybrid compounds have been obtained containing basic structure of conazole nucleus and their biological activities have been studied.

NHNEtO

O

NNEtO

O

NO2

F

NNEtO

O

NH

F

NHNH2

O

1 2

F

F

NO2+

NNEtO

O

NH

F

N

NN

SH

NNEtO

O

NH

F

N

NN

S

OH

Cl NNEtO

O

NH

F

N

NN

S

O

Cl

ClCl

i

ii, iii, iv

v, vi

vii, viii

i: reflux, ii: Pd-C, NH2NH2, iii: BrCH2COOEt, iv: NH2NH2, v: Ph-NCS, vi: %10 KOH, vii: Na, BrCH2COPhCl, viii: NaBH4, ix: NaH, 2,6-dichlorobenzoylchloride

ix

34

5 6

Figure 1. Proposed reaction mechanism of compound 6

References 1. S. Yu, X. Chai, H. Hu, Y. Yan, Z. Guan, Y. Zou, Q. Sun, Q. Wu, Eur. J. Med. Chem. 2010, 45, 4435-

4445 2. J.R. Wingard, H. Leather, Biol. Blood Marrow Transplant. 2010, 10, 73-90

Acknowledgment This study is supported by Turkish TUBITAK program (Project number 113Z181)


238

PO-107 Supercapacitor device preparation and Equivalent circuit model evaluation of Poly(3,6-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-9-tosyl-9H-carbazole)/Carbon nanotube as

an active material*

Nesimi ULUDAGa, and Murat ATESa aDepartment of Chemistry,Faculty of Art and Science, Namik Kemal University, TR-59030, Tekirdag, Turkey

Abstract: In this study, we have prepared the supercapacitor device preparation of a new synthesis monomer and polymer, which is named as poly(3,6-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-9-tosyl-9H-carbazole) [1]. This new monomer was used as active material in symmetric supercapacitor device. Active material was characterized by cyclic voltammetry (CV), Fourier transform infrared spectroscopy (FTIR)-Attenuated total reflectance (ATR), scanning electron microscopy (SEM)- energy dispersive X-ray analysis (EDX), atomic force microscopy (AFM) and electrochemical impedance spectroscopy (EIS) analysis. CV and also constant current (CC) measurements of the supercapacitor device are given as a composite material with polymer and carbon nanotube (CNT). Supercapacitor measurements were given in literature [2-4]. Optimization measurements are taken by different DC voltage. Equivalent circuit model of Rs(C1(R1(Q(R2W))))(CGCERGCE) is used to fit the theoretical and experimental data.

Scheme1.The equivalent circuit model of Rs(C1(R1(Q(R2W))))(CGCRGC).

*This study is supported by a grant (Project Number: 110T791) from The Scientific and Technological Research Council of Turkey.

References

1. M. Ates, N. Uludag, T. Karazehir, F. Arican, Ovidius University Annals of Chemistry,2012, 23, 63-71. 2. A. Rudge, J. Davey, L. Raistrick, S. Gottesfeld, J.P. Ferraris, J. Power Sources, 1994, 47, 89-107. 3. C. Arbizzani, M. Mastagostino, S. Passerini, R. Pileggi, B. Scrosati,Electrochim. Acta,1991, 36(5-6),

837-840. 4. A.K. Shukla, S. Sampath, K. Vijayamohanan, Curr. Sci., 2000, 79, 1656-1661.

239

PO-108 Concise Total Synthesis of 20-Deethyl-4-demethyldasycarpidone*

Nesimi ULUDAG, Medet YAKUP

Department of Chemistry,Faculty of Art and Science, Namık Kemal University, TR-59030, Tekirdağ, Turkey Abstract:

Dasycarpidone, 20-deethyldasycarpidone, 20-deethyldasycarpidone and 20-deethyl-4-demethyldasycarpidone

and strychnine possess the tetracyclic ring system of the Strychnos

indole alkalkoids.1-4 The biological activities of these compounds make them of great pharmacological interest and have led to a

sustained effort in the development of methods for their preparation; the tetracyclic ring system is believed to be primarily

responsible for their analgesic, anti-inflammatory, bactericidal, central nervous system depressant properties.

Scheme1.Syntheses of20-Deethyl-4-demethyldasycarpidone.

*This study is supported by a grant (TUBITAK Project No.102T503) from The Scientific and Technological Research Council of Turkey

References 1. N. Uludag, M. Sanda, O. Asutay and N. Coskun, Org. Prep. Proc. Int., 2014, 46, 551. 2. S. Patir and N. Uludag, Tetrahedron, 2009, 65, 115. 3. M. C. Mollo, N. Gruber, J. E. Diaz, J. A. Bisceglia and L. R. Orelli, Org. Prep. Proc. Int., 2014, 46, 444. 4. J. Gracia, J. Bonjoch, N. Casamitjana, M. Amat and J. Bosch, J. Chem. Soc., Chem. Commun., 1991,

614. 5. M. L. Bennasar, T. Roca and D. Garcia-Diaz, J. Org. Chem., 2008, 73, 9033.

240

PO-109

Supercapacitor Study of Poly(2-(3,6-bis(-(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-9H-carbazole-9-yl)ethyl methacrylate)/Carbon Nanotube Composite Material*

Murat ATESa, and Nesimi ULUDAGa

aDepartment of Chemistry,Faculty of Art and Science, Namik Kemal University, TR-59030, Tekirdag, Turkey Abstract: In this study, the supercapacitor electrode material of 2-(3,6-bis(-(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-9H-carbazole-9-yl)ethyl methacrylate was synthesized and electrochemically polymerized on glassy carbon electrode [1]. The polymer was characterized by cyclic voltammetry (CV), Fourier transform infrared spectroscopy (FTIR)-Attenuated total reflectance (ATR), scanning electron microscopy (SEM)-energy dispersive X-ray analysis (EDX), atomic force microscopy (AFM) and electrochemical impedance spectroscopy (EIS) analysis. Supercapacitor measurements of polymer and composite films by changing DC potentials were taken by CV method. Carbon nanotube was increased the specific capacitance values. Stability and also equivalent circuit model evaluations were performed to fit the theoretical and experimental data.

Scheme1.Electrogrowth of 2-(3,6-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-9H-carbazole-9-yl)ethyl methacrylate by

chronoamperometric method, [Com]0= 1.5 mM, constant potential of 1.6 V, 300 s, in 0.1 M NB4BF4/CH3CN, inset: The structure of polymer.

*This study is supported by a grant (Project Number: 110T791) from The Scientific and Technological Research Council of Turkey.

References

1. M. Ates, N. Uludag, T. Karazehir, F. Arican, J. Electrochem. Soc., 2013, 160(1), G46-G54.

241

PO-110 Synthesis of Mid-Chain Functional Macrophotoinitiators of Poly(D,L-lactide)-Based

Polymers by ROP and Their Use in Photoinitiated Polymerization*

Mustafa DEGIRMENCI, Mustafa DURGUN, Esra BARIM

Harran University, Science Faculty, Department of Chemistry, 63190 Sanliurfa, Turkey Abstract: In this study, novel biobased and environmental-friendly mid-chain functional macrophotoinitiators of poly(D,L-lactide)-based polymers have been synthesized via ring opening polymerization (ROP). Mid-chain functional poly(D,L-lactide) (PDLLA-PI-PDLLA) macrophotoinitiator was prepared by ROP of D,L-lactide (DLLA) monomer using a dihydroxy-functional photoinitiator (HO-PI-OH) as the initiator and stannous-2-ethyl hexanoate (Sn(Oct)2) as the catalyst. Tetrablock poly(D,L-lactide)-poly(caprolactone) copolymer (PDLLA-PCL-PI-PCL-PDLLA) with a mid-chain photofunctional group was synthesized via sequential ROPof caprolactone and D,L-lactide using Sn(Oct)2 as the catalyst. The resultant polymers were fully characterized by means of 1H NMR, FTIR, UV-vis, Fluorescence and GPC techniques. The obtained macrophotoinitiators were used as a prepolymer in photoinitiated free radical polymerization for obtaining AB type di- and ABC type tri-block copolymer. The molecule structures of the synthesized poly(D,L-lactide)-based macrophotoinitiators are as follow.

Scheme1.The molecule structures of macrophotoinitiators

*This study is supported by a grant (Project Number: 12160) from Scientific Research Projects Committee of Harran University (HÜBAK).

References

1. M. Degirmenci, G Hizal, Y Yagci,Macromolecules,2002, 35, 8265-8270. 2. T Corrales, F Catalina, C Peinado, N.S. Allen, J. Photoch. Photobio. A.2003, 159,103-114.

242

PO-111 Synthesis, Characterization, Catalytic and Cytotoxic Activities of a Novel

Pyridyloxycyclophosphazene Ligand and its Ru(II) Complex*

Zafer UYAR a, Digdem ERDENER ÇIRALIb, İsmail KOYUNCUc aDepartment of Chemistry,Faculty of Arts and Sciences,Harran University, Şanlıurfa,Turkey

bDepartment of Chemistry, Faculty of Arts and Sciences, ÇanakkaleOnsekiz Mart University, Çanakkale, Turkey cDepartment of Biology, Faculty of Arts and Sciences, Harran University, Şanlıurfa,

Abstract: Pyridyloxycyclophosphazenesaremultisitecoordination ligands wherethecoordinatingpyridine ligand is attachedtothephosphorus atom of the cyclophosphazene ring [1-2]. Whenthese ligands arecombinedwithtransitionmetalsor main groupmetals, a number of differentcomplexes, whichexhibit a richdiversityandpotentialchemicalandbiologicalactivities, can be readilyprepared. With these facts in mind, we have synthesized a novel cyclotriphosphazene ligand (1) bearing 3-oxypyridine moieties and its corresponding Ru(II) complex (2). Their structures were characterized by FT-IR, 1H-NMR, 31P-NMR spectroscopic data and elemental analysis. Ru(II) complex (2) was used as catalyst for catalytic transfer hydrogenation of p-substituted acetophenone derivatives in the presence of KOH. Additionally, cytotoxic activities of compounds 1 and 2 were evaluated against a panel of cancerous cell lines and normal human cell lines. As a result, Ru(II) complexshowed efficient catalytic activity towards transfer hydrogenation of acetophenone derivatives, especially bearing electron withdrawing substituents on the para-position of the aryl ring. Compounds were found to have moderate to high cytotoxic activity and Ru(II) complexation enhanced cytotoxic activity in comparison with the parent compounds.

Scheme1.Ru (II) complexofpyridyloxycyclophosphazene (2)

*Thisstudy is supportedby a grant (112T584) fromScientificand Technical ResearchCouncil ofTurkey (TUBITAK).

References

1. E. W. Ainscough, A. M. Brodie, C. V. Depree, G. B. Jameson, C. A. Otter, Inorg. Chem. 2005, 44, 7325. 2. V. Chandrasekhar, B. M. Pandian, R. Azhakar, Polyhedron2008, 27, 255.

243

PO-112 Investigation of Properties of Water Soluble 1-[2-(dimethylamino)ethyl]-1H-tetrazole

Substituted Metal-free and Zinc(II) Monophthalocyanines Ebru Yabaşa , Esra Bağdab

a Cumhuriyet University, Faculty of Science, Department of Chemistry, Sivas, Turkey b Cumhuriyet University, Faculty of Pharmacy, Sivas, Turkey

[email protected]

Abstract:

Phthalocyanines have been intensively investigated in especially medicine and pharmaceutical industry due to the properties

such as antioxidant activity and used as photosensitizers in photodynamic cancer therapy [1,2]. Substituent-free phthalocyanines

are not soluble in water and organic solvents. The lower solubility of phthalocyanines causes many problems in their application in

medicine. It is important to synthesize water soluble phthalocyanines in biomedical applications [3]. On the other hand, tetrazole

derivatives are interest due to anticancer and antibacterial properties [4].

In this study,biological properties ofthe synthesized water soluble metal-free and zinc(II) phthalocyanines have been

investigated.As a result,it was determined that these compounds have the potential to be utilized for the photodynamic

cancertherapy.

*This study is supported by a grant (İMYO-001) from Scientific Research Projects Committeeof Cumhuriyet University.

References

1. G. P. Amaral, G. O. Puntel, C. L. D. Corte, F. Dobrachinski, R. P. Barcelos, L. L. Bastos, D. S. Ávila,J.

2. B. T. Rocha, E. O. Silva, R. L. Puntel, F. A. A. Soares; Toxicology in Vitro, 2012, 26, 125-132.

3. M. Durmuş, V. Ahsen; J. Inorg. Biochem.,2010, 104 297-309.

4. T. Nyokong; Coord. Chem. Rev.,2007, 251, 1707-1722.

5. C. N. S. S. P. Kumar, D. K. Parida, A. Santhoshi, A. K. Kota, B. Sridhar, V. J. Rao;Med. Chem.

Commun.,2011, 2, 486-492.


http://pubs.rsc.org/en/results?searchtext=Author%3AChebolu%20Naga%20Sesha%20Sai%20Pavan%20Kumar

http://pubs.rsc.org/en/results?searchtext=Author%3ADusmant%20Kumar%20Parida

http://pubs.rsc.org/en/results?searchtext=Author%3AAmlipur%20Santhoshi

http://pubs.rsc.org/en/results?searchtext=Author%3AAnil%20Kumar%20Kota

http://pubs.rsc.org/en/results?searchtext=Author%3ABalasubramanian%20Sridhar

http://pubs.rsc.org/en/results?searchtext=Author%3AVaidya%20Jayathirtha%20Rao

244

PO-113 Synthesis and Spectral Charaterization of 4-Nitro-2-(5-chloro/methy-1,3-benzoxazol-2-

yl)phenols*

Demet GÜRBÜZ, Adem ÇINARLI, Aydın TAVMAN, Süleyman TANYOLAÇ İstanbul University, Faculty of Engineering, Department of Chemistry, 34320, Avcilar, İstanbul-TURKEY. E-mail.

[email protected]

Abstract: Benzoxazole ring is one of the most common heterocycles in medicinal chemistry. Previous reports revealed that substituted benzoxazoles possess diverse chemotherapeutic activities including antibiotic, antimicrobial, antiviral, topoisomerase I and II inhibitorsand antitumor activities [1].In addition, benzoxazoles are found in a variety of natural products and are important targets in drug discoveryand also find applications in material science as photochromic agentsand laser dyes [2]. In this study, firstly we synthesized Schiff bases using 2-amino-4-(chloro/methyl)phenols and 5-nitro-2-hydroxybenzaldeyde. Then 4-nitro-2-(5-chloro/methyl-1,3-benzoxazol-2-yl)phenols (Fig. 1) were synthesized by via the oxidative intramolecular cyclization of the corresponding Schiff bases, using iodobenzene diacetate (IBD) as an oxidant in ethanol at room temperature for 3 h [3]. The compounds were characterized by elemental analysis, 1H- and 13C-NMR, FT-IR, Raman, ESI-MS, and fluorescence spectroscopy.

N

O

ROH

NO2

Fig. 1. Chemical structure of the title compounds (R = Cl, CH3)

According to the 1H-NMR and FT-IR spectral data, there are inter- and intra-molecular hydrogen bonding in the compounds, between the phenolic OH hydrogen and the C=N nitrogen atoms. The 1H-NMR signal of the OH proton appears above 12.00 ppm for both compounds as broad signal. Fluorescence spectra of the compounds were measured in various solvents. The compounds fluoresce weakly around 500 nm in ethanol. *This work was supported by the Scientific Research Projects Coordination Unit of Istanbul University. References 1. Y. Chen, N. Xie, J. Photochem. Photobiol. A: Chem. 179 (2006) 320; M. R. Deluca, S. M. Kerwin, Tetrahedron Lett. 38 (1997) 199. 2. Y. Sato, M. Yamada, S. Yoshida, T. Soneda, M. Ishikawa, T. Nizato, K. Suzuki, F. Konno, J. Med. Chem. 41 (1998) 3015. 3. R. S. Varma, R. K. Saini, O. Prakash, Tetrahedron Lett. 38 (1997) 2621.

245

PO-114 Synthesis and Spectral Characterization of 1,3-bis(1H-benzimidazol-2-yl)-2-Oxapropane

Complexes with Various Zn(II) Salts*

Aydin TAVMAN, Adem ÇINARLI

Istanbul University, Faculty of Engineering, Chemistry Department, Avcilar, 34320, Istanbul, Turkey.

Abstract:

Bis-benzimidazoles are strong chelating agents coordinating through both of the C=N groups nitrogen atoms. In addition, the benzimidazole ring system is present in clinically approved antihelmintics, antiulcers, antivirals and antihistamines [1]. Recently, there have been reports on benzimidazole derivatives exhibiting antitumor and antimicrobial properties and acting as thrombopoietin receptor agonists [2,3]. In this study, 1,3-bis(1H-benzimidazol-2-yl)-2-oxapropane (L) complexes with ZnX2 (X = CH3COO–, NO3

–, Cl–,ClO4–) (1 – 4) were

synthesized and characterized by elemental analysis, molar conductivity, TGA, FT-IR, NMR, ESI-MS and fluorescence spectroscopy. The ZnCl2 complex (3) is structurally different from the others: It shows a broad signal at 7.28 ppm in the 1H-NMR spectra assigned to two coordinated water molecules. The very low solubility of the acetate complex (1) leads us to suggest a polymeric structure with [Zn2(μ-OAc)4(L)2]n paddlewheel units. The ligand shows from two to four emission bands in polar solvents. Compared to the ligand, the complexes show weak fluorescence intensity in ethanol and exhibit red- or blue-shift.

NH

NNH

NO

NH

N

NH

NO

NH

NNH

NO

NH

N

NH

N O

CH3

O

O

CH3

O

O

CH3

O

Zn

CH3

O

O

O

Zn

Zn

Zn

Zn

Zn

Figure 1. The suggested polymeric structure of the zinc(II) acetate complex (1). *This work was supported by the Scientific Research Projects Coordination Unit of Istanbul University.

References 1. Harrell, C. C.; Kohli, P.; Siwy, Z.; Martin, C. R. J. Am. Chem. Soc.2004, 126, 15646-7. 2. Sun, T.; Li, K.; Lai, Y.; Chen, R.; Wu, H. Acta Cryst.2010, E66, m1058. 3. Chang, C. M.; Kulkarni, M. V.; Chen, C. H.; Wang, C.; Sun, C. M. J. Comb. Chem.2008, 10, 466-474.

246

PO-115 The Synthesis and Characterization of Some New S-, S,S- and N,S-Substituted

Nitrobutadienes F. Serpil Göksel, Elif Aydın

University of Istanbul, Faculty of Engineering, Department of ChemistryAvcilar, 34320, Istanbul, Turkey

Abstract: The piperazine derivatives have been subjected to medicinal applications and gen transfer studies due to their interesting biological activity and chemical effects. Some piperazine derivatives possess high biological activity for multidrug resistance in cancer. In our previous study, we reported the synthesis of mono-, bis-, tris-, and tetrakis(thio)substituted nitrobutadiene compounds from the reactions of nitrobutadiene with some thiols. In thisstudy, the mono(thio) and bis(thio) substituted nitrodiene compounds were synthesized from nitrodiene and thiols. In the following step, mono(thio) substituted nitrodiene compound were treated with some piperazine derivativesand N,S- substituted nitordiene compounds were achieved. Reaction products were purified by column chromatography. Structures of these novel products were determined by microanalysis and spectroscopic methods (IR, 1H-NMR, 13C-NMR, UV and MS).

R1:

R2:

Cl

Br

Cl

NO2

Cl

Cl

Br

Cl

NO2

S R1

S R1

S R1

OCH3

Cl

Br

Cl

NO2

S R1

NN R2

Figure 1. General formula of synthesized compounds.

References

V.A. Zapol’skii, J.C. Namyslo, M. Gjikaj, D.E. Kaufmann, Arkivoc. 2007, (i), 76. C. Ibiş, F. S. Goksel, and G. Aydınlı, Phosphorus, Sulfur and Silicon, 2003, 178, 777 . F. S. Goksel, E.Aydin, and C. Ibiş, Phosphorus, Sulfur, Silicon Relat. Elem.,2014, 189,1867-1872. S. Zhoa, A.K. Miller, Tetrahedron Lett., 1996, 37, 4463.

247

PO-116 Synthesis of New N- Substitutedp-chloroanil Compounds and Their Thio- Substituted

Derivatives Hakan BAHARa, Sibel ŞAHİNLER AYLAa, Funda ÖZKÖKa, Cemil İBİŞa

aIstanbul University, Engineering Faculty, Department of Chemistry, Istanbul, TURKEY Abstract:

The reactions of 1,4-benzoquinone with different N- or S- nucleophilles have been working in many years at

organic chemistry.[1-2]. These N- and S- substituted derivatives of quinone structure are very important because

of their significant pharmacological applications such as abtibacterial, antibiotic, antimalarial compounds[3]. In

thisstudy novel N-substituted p-chloranilecompounds were synthesized and then treated with some thiols and

N,S- substituted quinone compounds were obtained. The structures of new products were characterized by

elemental analysisi and spectroscopic methods suc as 1H-NMR, 13C-NMR, FT-IR and MS.

O

O

NR1

Cl

Cl

Cl

O

O

NR1

Cl

Cl

R1N

O

O

NR1

SR2

R2S

R1N

O

O

NR1

SR2

Cl

R1N

O

O

NR1

SR2

R2S

R2S

O

O

NR1

SR2

Cl

R2S

, ,

, ,

R1, R2: Aromatic or Aliphatic groups

Scheme1.Obtained N-, N,S- substituted Benzoquinone products from 1,4-Benzoquinone

References

1. Ibis, C.; Sahinler Ayla, S.; Doğan, Y; Özen, M. “Synthesis and Characterization of Novel N-, S-, O- Substituted p-chloranil Derivatives”, Synthetic Communications, 44, 1614-1618 (2014).

2. Ibis, C.; Sahinler Ayla, S.; Yavuz, S. “The Synthesis, Characterization and Electrochemical

Investigation of Novel Thio- and Alkoxy Substituted Benzoquinone Derivatives”, Phosphorous, Sulfur

and Silicon and the Related Elements, 189, 492-502, (2013). 3. Batra, M., Kriplani, P., Batra, C., Ojha, K. G. Bioorgan Med Chem. 2006, 14(24), 8519–8526.O.

Çakmak, R. Erenler, A. Tutar; J. Org. Chem. 2006, 71, 1795-1801.

248

PO-117 Synthesis and Spectroscopic Characterization of Novel N- and N,S-Substituted

Naphthoquinone Compounds

Sibel ŞAHİNLER AYLA, Hakan BAHAR, Cemil İBİŞ Department of Chemistry,Faculty of Engineering, Istanbul University, TR-34320, Istanbul, Turkey

Abstract: The investigation of substitution reactions of the naphthoquinone unit has been studied in the last decade1-2. The structure of 2,3-dichloro-1,4-naphthoquinone unit enables the substitution of chlorine atoms with N- or S- nucleophilles3.The biological importance of 1,4-naphthoquinone framework prompted chemists to design and synthesize novel derivatives of these kind of compounds. The structures of these novel compounds were characterized by using Micro analyses, 1H-NMR, 13C-NMR, FT IR and MS.

O

O Cl

N N NHO

Cl

O

O SR1

N N NHO

Cl

R1 : Aliphatic, aromatic groups…etc

Scheme1. Obtained products from substitution reactions.

References

1. C. Ibis,, A. F. Tuyun,, H. Bahar, S. Sahinler Ayla, M.V. Stasevych, R.Y. Musyanovych, O. Komarovska-Porokhnyavets, V.P. Novikov. Med. Chem. Res.2014, 23, 2140.

2. K. M. El-Shaieb. J. Chin. Chem. Soc.2007, 54, 1353. 3. V.K. Tandon, H.K. Maurya, Heterocycles2008, 76, 1007-1010.

249

PO-118 Synthesis and Spectral Characterization of 5-Chloro-2-(5-Chloro/Methyl-1,3-Benzoxazol-2-

yl)Phenols

Demet GÜRBÜZ, Adem ÇINARLI, Aydın TAVMAN

Department of Chemistry, Faculty of Engineering, Istanbul University, 34320, Avcilar, Istanbul, Turkey. Abstract: Molecules with benzoxazole,benzimidazole, benzothiadiazoles moieties are attractive targets for synthesis since they often exhibit diverse and important biological properties. These heterocycles have shown different pharmacological activities such as antibacterial agents, antibiotics, antiparasitic, anti-inflammatory, elastase inhibitors, anti-stress, ulcer and anti-cancer agents, antiviral and antiparkinson properties[l-3]. They have also been used as ligands for asymmetric transformations[4]. In this study, we synthesized5-chloro-2-(5-chloro/methyl-1,3-benzoxazol-2-yl)phenols (Fig. 1) by via the oxidative intramolecular cyclization of phenolic Schiff bases. The compounds were characterized by elemental analysis, 1H- and 13C-NMR, FT-IR, ESI-MS, and fluorescence spectroscopy.

N

O

R

OH

Cl

Figure 1. Chemical structure of the title compounds (R = Cl, CH3)

*This work was supported by the Scientific Research Projects Coordination Unit of Istanbul University.

References

1. S. Alper-Hayta, M. Arısoy, O. Temiz-Arpacı, I.E.Yildiz, O.A. Kaynak;J. Med. Chem. 2008,43, 2568-2578. 2. X. Song, B.S.Vig, P.L. Lorenzi, J.C. Drach, L.B. Townsend, G.L. Amidon; J. Med. Chem. 2005, 48, 1274-

1277. 3. A.Benazzou, T. Boraund, P. Dubedat, J. Boireau, M. Stutzmanni; Eur. J. Pharmcol.1995, 254, 299- 307 4. A. Figge, H.J. Altenbach, D.J. Brauer, P. Tielmann; Tetrahedron:Asymmetry, 2002, 13, 137-144

250

PO-119 Determination of Phenolic Acids in Concentrated and Non-concentrated Apple Juice

Made from Denizli by High-Performance Liquid Chromatography DAD

MürüvvetKarakaplana, Mustafa Özcanb a, bDepartment of Chemistry, Faculty of Science, İstanbul Technical University, Maslak ,34469 İstanbul, Turkey

Abstract: In this study, five phenolic acids, gallic, chlorogenic, caffeic, p-coumaric and ferulic acide were determined infreshly squeezed apple juice, commercial apple juice and apple juice concentrate beverages. For this purpose, an analytical method using high-performance liquid chromatography (HPLC), with a combination of photodiode array detection (DAD), was developed for the characterization and quantification of phenolic acid in apple juices .Then the analyses of apple juices were performed. 10,3±0,05 mg/L of gallic acid, 103,7±0,06 mg/L of chlorogenic acid, 20,6±0,06 mg/L of caffeic acid, 8±0,07 mg/L p-coumaric acid and 6,3±0,04 mg/L of ferulic acid were quantified in freshly squeezed apple juice. 10,7±0,03 mg/L of gallic acid, 212±0,06 mg/L of chlorogenic acid, 29,4±0,05 mg/L of caffeic acid, 13,9±0,05 mg/L p-coumaric acid and 10,8±0,03mg/L of ferulic acid were quantified in commercial apple juice. 8,3±0,07 mg/L of gallic acid, 95,6±0,04 mg/L of chlorogenic acid, 18±0,06 mg/L of caffeic acid, 4,9±0,06 mg/L p-coumaric acid and 2,7±0,03 mg/L of ferulic acid were quantified in apple juice concentrate. The recoveries of phenolic compounds were found within the range 92,7 -99,6 % by this method. This study will be conducted using fruit in the Denizli region between the years 2013-2014.

References

1. Hakkıen , S., Karenlamp, S.O., Heınonen, I.M., Mykkanen, H.M. and Torronen, A.R., 1998. HPLC

Method for Screening of Flavonids and Phelonic Acids in Berries. J. Science Food Agric , 77: 543-551. 2. Zhanag, J., Zhan, B., Yhao, X., Goa, Y. and Shang, J., 1995. Antiviral Activity of Tanin From The

Pericap of Punica Granatum L. Aganist Herpes Virus Invitra. Chung Kuo ChungTsa Chih, 20: 556-558. 3. Garcia-Alanso, M., Pascual-Teresa, S., Santos-Buelga, C., and Rivas-Gonzalo, J.C., 2004. Evalution of

the Antioxidant Propeties of Fruits. Food Chemistry, 84:13-18. 4. Karadeniz, F. 1993. Elma Suyunda Fenolik Madde Dağılımı ve Konsantreye İşleme Sıarsındaki

Değişimi. A.Ü. Fen Bil. Ens., Gıda Bilimi Ve Teknolojisi ABD, Doktora Tezi, 63s 5. Çam, M., Hışıl, Y., Durmaz, G. 2009. Classification of eight pomegranate juices based on antioxidant

capacity measured by four methods. Food Chemistry., 112: 721–726.

251

PO-120 Hydrogen Generation from Sodium Borohydride Hydrolysis Using Co-B Catalyst on

Supported Sepiolite Seda EROL, Mine ÖZDEMİR

aDepartment of Chemical Engineering,Faculty of Engineering and Architecture, Eskişehir Osmangazi University, TR-26480, Eskişehir, Turkey

Abstract: Recently, the increasing of energy demand has become a serious issue with the rapid economic development around the world.

Hydrogen is a potential material to meet the increasing demand for efficient and clean energy. Chemical borohydride is currently attractive as a hydrogen generation material. Among the chemical borohydrides, sodium borohydride (NaBH4) is more favorable due to its advantages of high hydrogen density (10.8 wt.%) and strong stability in alkaline solution. A large number of researches have been made on the catalysts for the hydrolysis of sodium borohydride. However, there does not exist any study on Co-B / sepiolite. The aim of this study is to investigate the hydrogen generation from sodium borohydride hydrolysis using Co-B catalyst supported on sepiolite. The catalyst was prepared by impregnation using cobalt (II) chloride solution and then was reducted by sodium borohydride solution. The catalytic activity of the prepared catalyst was tested by hydrolysis of sodium borohydride in a semi-batch system. Effects of the catalysts amount, sodium borohydride concentration and reaction temperature on hydrogen generation were investigated. The hydrogen generation efficiency increased with increasing the catalysts amount, sodium borohydride concentration and reaction temperature. The kinetics of catalytic hydrolysis reaction was also investigated. The reaction kinetics obeyed the zeroth order kinetic model. The activation energy of reaction was found to be 44,93 kJ/mol.

References

1. S. S. Muir, X. Yao, Int J Hydrogen Energy, 2011, 36, 5983-5997. 2. F. Li, Q. Li, H. Kim, Chem. Eng. J., 2012,210,316-324. 3. J. Chang, H. Tian, F. Du, Int J Hydrogen Energy, 2014, 39, 13087-13097.

252

PO-121 Adsorption Thermodynamic Parameters of SBA15 and B-SBA-15 Mesoporous Materials

by Using Inverse Gas Chromatography Technique

Alime Çıtak*, Tuğba Candaş

Chemical Engineering Department, Eskisehir OsmangaziUniversity, 26480 Eskisehir, TURKEY

*[email protected]

[email protected]

Abstract: According to the other mesoporous materialsSBA-15 stands out in terms of larger pore sizes, hydrothermal stability and having a thicker wall structure. SBA-15 which is commonly used in industrial separation, adsorption, catalysis, sensor, the reactions of solution and gas and in many areas is to be mainly produced by combining certain proportions of polymer (P123) and silica (TEOS). In the literature review, it is found that mesoporous materials supported boron (B) affect the surface properties. In this study, pure SBA-15 synthesized by hydrothermal synthesis method and different molar ratios (nSi / nB = 50, 16) of boron B-SBA-15 were synthesized by direct hydrothermal synthesis method [1], and the inverse gas chromatography (IGC) technique was used in order to determine the adsorption thermodynamic parameters of the samples. All of the SBA-15 samples were used as filler for the column of the gas chromatography device and were determined adsorption thermodynamic parameters of unknown properties of SBA-15 sample using probe gas molecules with known properties. Also, BET, ICP-OES, SEM, FT-IR and XRD analysis were used for the characterization of samples. According to data obtained from analysis results, all of the samples have characteristic structure of SBA-15. According to data obtained from experimental results, ΔH°, ΔS° and ΔG° values were calculatedfor all used as a filler SBA-15 samples. In addition, starting from these values the surface acidity and basicity characteristics KA and KD valuesfor all the samples were calculated.

Keywords: SBA15, Direct hydrothermal synthesis, Mesoporous materials, Inverse gas chromatography (IGC), Adsorption thermodynamic parameters. Acknowledgements: This work was supported by the Commission of Scientific Research Project of ESOGU (GR/201315049).

References

1. Aktaş Ö., Development Of SBA-15 And MCF Supported Catalysts For Selective Oxidation Reaction Of Propane To Propylene, M.Sc. Thesis, Institute Of Science And Technology,Gazi University, Ankara, 2008. 2. Rückriem M., Inayat A., Enke, D., Gläser R., Einicke W.-D., Rockmann R., Inverse gas chromatography for determining the dispersive surface energy of porous silica, Colloids and Surfaces A: Physicochem. Eng. Aspects 357 (2010) 21–26.


253

PO-122 The Synthesis and Characterization of New Oxime Ligands and Their Complexes with

Cu(II) Metals* Tufan TOPAL, Emin KARAPINAR

Department of Chemistry,Faculty of Art and Science, Pamukkale University, TR-20020, Denizli, Turkey

Abstract: Oximes and Schiff bases are the two important classes of compounds owing to their wide applications in industry, medicine,

detection and determination of various metal ions and these are now being widely used to synthesize mono-, di- or polynuclear

transition metal complexes. In this work, Isonitroso-p-chloroacetophenone have been isolated through the nitrosation reaction

between starting material and butlynitrite by sodium ethoxide medium. Isonitroso-p-chloroacetophenone were reacted with

diamine (3,4 Diaminotoluen) [HL1], has been synthesized and its mono-,di- and trinuclear copper(II) complexes have been prepared

and characterized by magnetic moments, 1H-and 13C-nmr., i.r. and mass spectral studies. The data support the proposed structure of

dioxime ligand and its Cu(II) complexes.

N

H

H

NN

NO

O

Cu

Cl

Cl

OH2

N

H

H

N N

N O

O

Cu Cu

Cl

Cl

OH2

CH3CH3

(ClO4)2

++

Scheme1.Structural scheme of the homotri-nuclear Cu(II) complexes

*This study is supported by a grant (2013FBE041) from Scientific Research Projects Committeeof Pamukkale University.

References

1. B. Dede, F. Karipçin, M. Cengiz, J. Chem. Sci.,2009, 121, 163–171 2. S. Karaböcek, N. Karaböcek, A. Armutcu, Transition Met. Chem,2006, 31, 459–464 3. F. Karipçin, G.Baskale-Akdoğan, J.Incl Phenom Macrocycl.Chem., 2009, 64, 183–192.

254

PO-123 Characterization of Natural Organic Matter (NOM) by Resin Adsoprtion Method in Drinking

Waters* Tufan TOPALa, Nazan KARAPINARa, Vedat UYAKb

aDepartment of Chemical Engineering, College of Engineering,Pamukkale University, TR-20020, Denizli, Turkey aDepartment of Environmental Engineering, College of Engineering,Pamukkale University, TR-20020, Denizli, Turkey

Abstract: When chlorine is applied to drinking water processes, it reacts with natural organic matter (NOM) and forms various types of chlorinated disinfection by-products (DBPs). Epidemiologic studies showed that these types of chlorinated compounds have been recognized as carcinogenic chemicals in terms of human health. THM and HAA are the major DBP compounds.In this study, using XAD resins, we investigated changes on NOM fractions between THM and HAA formation in drinking water samples taken from Terkos Lake in İstanbul.Adsorbent resin (XAD-8, XAD-4) was used to separate the water soluble organic substances into three groups: hydrophobic (HPO), hydrophilic (HPI) and transphilic (TPI) acids to obtain a better picture of the NOM distribution in the raw water(Scheme 1). It was concluded that the HPO fraction was the primary THM precursor, which contributed more than 48%, and the primary fraction of HAA precursors was found to be TPI contrary of that of THM precursor.

Scheme1.Schematic diagrams of the procedures for NOM fractionation.

*This study is supported by a grant (2010FBE020) from Scientific Research Projects Committee of Pamukkale University.

References

1.Thurman, E.M. & Malcolm, R.L., Environmental Sci. and Technology, 1981, 15, 463–466. 2.Leenheer, J.A., Environmental Science and Technology, 1981, 15, 578–587. 3. Uyak, V., Ozdemir, K., & Toroz, I. Science of Total Environment, 2008, 390, 418–425.

255

PO-124 Antioxidant Properties of Novel Mixed Ligand Complexes Obtained from Saccharinato

Complexes and Azo Dye Ligand (mnppa) Nevin Turana,Ragıp Adigüzelb,Kenan Bulduruna,Ercan Bursalc

aDepartment of Chemistry,Faculty of Art and Science, Muş Alparslan University, TR-49100, Muş, Turkey bDepartment of Chemical Engineering, Faculty of Engineering, Tunceli University, TR-62000 Tunceli, Turkey

cNursing Department, School of Health, Muş Alparslan University, TR-49250 Muş, Turkey Abstract: Three new mixed ligand-metal complexes with a general formula [M(Sac)2(H2O)2L2].nH2O] [M = Mn(II), Ni(II), Cd(II), Cu(II) and Co(II), L = 5-Methly-4-(4-nitrophenylazo)-2H-pyrazole-3-ylamine (mnppa)]have been synthesized and characterized by elemental analyses, IR, UV–VIS, magnetic susceptibility mass spectra, and thermogravimetry-differential thermal analysis (TGA-DTA). Each metal(II) ion is octahedral coordinated by two sac, two mnppa and two aqua ligands. The antioxidant properties of ligand-metal complexes were determinedby different in vitro methods such as ABTS, DPPH, FRAP and CUPRAC assays. The results of metal complexes were compared with standard antioxidant compounds. The data obtained by DPPH free radical scavenging, ABTS cation radical scavenging, FRAP and CUPRAC assays showed that chemical complex materials of this study had very low antioxidant properties, yet some of them performed better cupric ion reducing power.

Scheme1.Structure of saccharine, azo dye and Saccharin – aqua-complex

a) Saccharin, b) Neutral ligand (Azo dye), c) Saccharin – aqua-complex

References

1. H. Esener, R. Adiguzel, Z. Ergin et al.,Adv Sci Lett,2011, 4, 3669-3675, 2. E. Bursal, İ. Gülçin, Food Res Int, 2011, 44(5), 1482-1489.

256

PO-125 Synthesis and Catalytic Activity Studies of Ru Complexes Bearing

2-(1H-Benzimidazol-2-yl)quinoline Derivatives Melek Tercana, Osman Dayana, Namık Özdemirb

aDepartment of Chemistry, Faculty of Arts and Science, Çanakkale Onsekiz Mart University, 17020 Çanakkale, Turkey.

bDepartment of Physics, Faculty of Arts and Sciences, Ondokuz Mayıs University, 55139 Samsun, Turkey

Abstract: N-donor ligands that are used in the preparation of transition metal complexes are very attractive in literature by their specialities as convenience of synthesis and obtaining by inexpensive methods. Ruthenium complexes of N-donor ligands become very popular recently. Ruthenium metal provides various application areas (catalyst, solar cell, semi conductor tech. etc.) because of its wide oxidation state range and correspondingly changing coordination geometry [1,2]. In this study, 2-(1H-Benzimidazol-2-yl)quinoline derivatives and their Ru complexes were synthesized and their catalytic effect in oxidation reaction of benzyl alcohol to benzaldehyde were investigated. The best result was obtained for C2 complex.

Figure 1. Scheme of synthesized compounds

Acknowledgements We acknowledge Çanakkale Onsekiz Mart University Scientific Research Projects Commission (Project No: FBA-2014-179) for support and the Faculty of Arts and Sciences.

References

1.O. Oter, K. Ertekin, O. Dayan, B. Çetinkaya; Journal of Fluores. 2008, 18, 269–276.

2.H. Yi, J.A. Crayston, J.T.S. Irvine; Dalton Trans. 2003, 4, 685–691.

257

PO-126 Separation, Optimization and Quantitative Determination of Fruit Acids by New Mixed-

Model Column in HPLC * Uyan YÜKSELa, Hayriye ARALb,, K.Serdar ÇELİKc,

aDepartment of Chemical Technologies,Vocatinol School of Tecnical Sciences, Siirt University, TR-56100, Siirt, Turkey bDepartment of Chemistry, Faculty of Art and Science,Batman University, TR-72000, Batman, Turkey

cDepartment of Refinery and Petrochemical, Vocatinol School, Batman University, TR-72000, Batman, Turkey

Abstract: Fruits and vegetables contain widely distrubited organic acids. Organic acids are used broadly as food acitulants in the manufacturing of beverages, fruit ang vegetable drinks and juices. The principle acids used to increase beverage flavours are citric, tartaric, fumaric and phosphoric acids. Therefore, it is important to be able to precisely determine food acids present for quality

control purposes, as well as for meeting various laws and regulations and for labelling purposes1.

Scheme1.Structure of stationary phase

In our previous study, a new mixed-model stationary phase was developed and filled to 250x4.6 mm HPLC column and used

separation of some small polar compounds in HPLC 2. In current study, we synthesised this stationary phase again and filled to 150x4.6 mm empty HPLC column. This new column has been used for separation, optimization and quantitative determination of some organic acids from some fruit juices.

References

1. G.Shui, L.P. Leong, Journal of Chromatography A, 977(2002)89-96. 2. T. Aral, H. Aral, B. Ziyadanoğulları, R. Ziyadanoğulları, Talanta 131(2015)64-73.

O Si

OMe

O

OOHN

H

NH2

O

ONH

OH

OH

SP

258

PO-127 Quantitative Determination of Phenolic Compounds in Mushroom by New Mixed-model

Column in HPLC * K.Serdar ÇELİKa, Hayriye ARALb,, Uyan YÜKSELc

aDepartment of Refinery and Petrochemical, Vocatinol School, Batman University, TR-72000, Batman, Turkey

bDepartment of Chemistry, Faculty of Art and Science,Batman University, TR-72000, Batman, Turkey cDepartment of Chemical Technologies,Vocatinol School of Tecnical Sciences, Siirt University, TR-56100, Siirt, Turkey

Abstract: Mushrooms have been used for many years in oriental culture as tea and nutritional food and because of their special flavour and texture [1]. In this study we investigated the phenolic composition of mushrooms. Analysis of phenolic compounds in these edible mushrooms species has been carried out by high-performance liquid chromatography.

Scheme1.Structure of stationary phase

In our previous study, a new mixed-model stationary phase was developed and filled to 250x4.6 mm HPLC column and used

separation of some small polar compounds in HPLC 2. In current study, we synthesised this stationary phase again and filled to 150x4.6 mm empty HPLC column. This new column has been used for separation, optimization and quantitative determination of some phenolic compounds from some mushroom.

References

1. Manzi P et al. (1999) Food Chem 65: 477–482. 2. T. Aral, H. Aral, B. Ziyadanoğulları, R. Ziyadanoğulları, Talanta 131(2015)64-73.

O Si

OMe

O

OOHN

H

NH2

O

ONH

OH

OH

SP

259

PO-128 Chemical Compositions of Fatty Acid Obtained from Seeds of SilybummarianumL.

Gaertn(Thistle) by Using Cold Press

EyyüpKARAOĞULa*, M. HakkıALMAa, ÖmerÇIÇEKa, ErtuğrulALTUNTAŞa

aDepartment of Forest Industry Engineering, KahramanmaraşSütçü İmam University, 46100 Kahramanmaraş, Turkey

Abstract: SilybummarianumL.Gaertn (Thistle), which were cultivated inTurkoglu/Kahramanmaras of Mediterranean region of Turkey, is an important medicinal plantto treat liver diseases (1). Chemical composition of fatty acid isolated seeds of the thistleby using cold press were investigated by gas chromatography–flame ionization detection (GC–FID). The results showed that total 23 various fatty acid compounds were determined and the seed oils contained linoleic acid of 53,1 %, oleic acid of 21,9 %, palmitic acid of 9,1 %, stearic acid of 5,45 %, gama-linoleic acid of 3,7 % and cis- 8,11,14- eicosatrienoic acid of 2,57 %, as the major constituents, respectively. Key Word: SilybummarianumL. Gaertn, Thistle, GC–FID, major constituents References 1. J.Sonnenbichler, F.Scalera, I.Sonnenbichler, And R.Weyhenmeyer, 1999, Thejournal ofpharmacology

AndexperimentaltherapeuticsVol. 290, No.3

260

PO-129 Synthesis and Characterization of Methyl Cellulose Obtained from Cotton Waste:

Application in Cement Paste*

Ali KOÇa, Sümeyye AKARSUb, C. Ayhan ZIBAc, Mustafa DOLAZa,b,c

aInert Chemistry Industry and Trade Ltd. Co., TR-54400, Sakarya, Turkey bDepartment of Environmental Engineering, Faculty of Engineering and Architecture,

Kahramanmaras Sutcu Imam University, TR-46100, Kahramanmaras, Turkey cDepartment of Chemistry, Faculty of Science and Letter, Kahramanmaras Sutcu Imam University, TR-46100,

Kahramanmaras, Turkey Abstract: In countries the textile industry developed, accordingly, will be an increase in the amount of waste linter. During the process of towel woven in textile industry, the towels feathers (waste linter) on the surface of the cloth is either completely trimmed or partially cut them into a level. They are a major source of waste and their potential for cellulose derivatives should be investigated. As a renewable resource, cellulose, is used in the form of derivatives are important many decades after their discovery. Methylcellulose (MC) is a methyl ether that can be produced by a reaction between cellulose in an alkaline medium, with a methylating agent, such as methyl iodide, methyl chloride or dimethyl sulfate (DMS). In civil construction, methylcellulose is generally used in industrial mortar formulas to improve the workability of the fresh mortar and adhesion to the substrate1,2. MC is a derivative of cellulose which extensively applied in the pharmaceutical, food, petrochemical, civil construction and other industries. Its use is directly related to the degree of substitution (DS) that influences its physical properties such as water solubility. In this work, cellulose isolated from waste towels feather purified and bleached with high temperature in alkali medium. Dimethyl sulfate was used as

methylating agent. MC was characterized by FTIR, 1H-, solid-13C-NMR. The surface morphology was

investigated by SEM. The thermal behavior of the product was studied by DTA-TG, DSC analyses and viscometric characteristic was investigated. The application of MC on civil engineering was evaluated by the measurement of the flash setting time on cement paste. *This study is supported by a grant (Project Number: 2013/2-10 YLS) from Scientific Research Projects

Committee of Kahramanmaras Sutcu Imam University and Republic of Turkey Ministry of Science, Industry and Technology SANTEZ (Project Number: 021STZ2013-1)

References 1. R. G. P. Vieira, G. Rodrigues Filho, R. M. N. Assunção, C. S. Meireles, J. G. Vieira, G. S. Oliveira,

Carbohydr. Polym., 2007, 67, 182. 2. J. Pourchez, P. Grosseau, R. Guyonnet, B. Ruot, Cem. Concr. Res., 2006, 36, 1777.

261

PO-130 Anti-Microbial Activity of Volatile Oils Extracted From Citrus Aurantifolia L. on Several

Microorganisms

Muharam Yaseen MOHAMMEDa, Tufan SALANb, Eyyüp KARAOĞULa, M. Hakkı ALMAa

Department of Forest Industry Engineering, Kahramanmaras Sutcu Imam University, TR-46100, Kahramanmaras, Turkey Department of Material Science and Engineering, Kahramanmaras Sutcu Imam University, TR-46100, Kahramanmaras, Turkey

e-mail: [email protected]

Abstract: In this study, volatile oils of citrus lime (Citrus Aurantifolia L.) were extracted by using three different methods, which were water distillation by using Clevenger-type equipment (Method 1), extraction by using n-hexane (Method 2) and microwave assisted extraction technique into n-hexane (Method 3). Many comparisonswere made between methods based on solvent materials and the time of the procedure. Method 1 was carried out for about 8 hours in a flask heated by an electro thermal heater. In the second method, maceration extraction method was performed for 4 days in room temperature. Finally, in the third method, microwave assisted extraction was performed for about 30 min. After completion of the experiments, yield of the extracted oils were calculated by weighting the filtration residuesobtained from differentmethods. Finally, solvents were removed by using a rotary evaporator to

analyze the essential oils. Chemical content of the extracted oils were determined by using a GC-MS instrument. Moreover, ten species of microorganisms, includes gram-positive, gram-negative bacteria and one fungus, were used to determine the

antimicrobial activity of the oils via disk diffusion incubation procedure. The results showed that the highest amount of volatile oil (24%) was extracted by using microwave system. Method 1 and Method 2

followedthis method with a volatile oil content of 19% and 16%, respectively. According to the GC-MS results, D-Limonene and D-Dihydrocarbone were the majority of volatile oils that were extracted from the dried peels of the plant. Limonene is a colorless liquid hydrocarbon classified as a cyclic terpene. The more common D isomer possesses a strong smell of oranges. It is used in chemical synthesis as a precursor to carbon and as a renewably based solvent in cleaning product.The number of the identified compounds varied in a range of 19-22 based on the extraction method. According to the anti-microbial study, it was found that essential oil of fruit peels of C. aurantifulia was showed higher anti-microbial activity against especially Streptococcus pyogen, Staphylococcus aurious, Clostridium spp. and on fungus (Candida albicans) comparing the other species. The highest inhibition zones were found at the diluted concentration of 1:10, 1:20 and 1:30 (essential oil to dimethyl sulphoxide (DMSO) in the petri dishes. We recommend

further isolation and identification of the active ingredient (extracted volatile oil) of this plant responsible for pharmacological activities on bacteria and yeast for industrial purposes.

262

PO-131 Determination of Cobalt with Cloud Point Extraction

Ümit DİVRİKLİa Mustafa SOYLAKb Latif ELÇİa

aDepartment of Chemistry,Faculty of Art and Science, Pamukkale University, TR-20017, Denizli, Turkey

bDepartment of Chemistry, Faculty of Art and Science,Erciyes University, TR-38039, Kayseri, Turkey Abstract: Separation and preconcentration procedures are considered of great importance in analytical and environmental chemistry. Cloud point extraction is a separation and preconcentration procedure that has been extensively applied for trace metal determination in several different matrices. Its major advantages are simple experimental procedures, low cost, high preconcentration factors, and environmental safety. These aspects include it in a set of analytical methods in agreement with the “green chemistry” principles. In this study, cloud point extraction method was developed for the determination of trace amount of cobalt by flame atomic absorption spectrometry detection for separation and preconcentration.The method of optimization chosen was a chemometric method using a factorial design.The average recoveries were in the range of % 96,0 - 98,4 and the relative standard deviation was in the range of % 0,8-1,9.The detection limit (3s, N=12) was found to be 0,14 µg L-1, the quantitative limit was found to be 0,38 µg L-1 (10s, N=12). The method was applied to various water samples, dry mint and B12 vitamine.

References

1. L.H.Willie, E.Pramauro, Critic. Reviews in Anal. Chem., 1993, 24/2, 133 -177. 2. C.Vandecasteele, C.B. Block, Modern Methods for Trace Element Determination, 1997, 1-7.

263

PO-132 Synthesis and Characterization of Imine Polymers Containing Methyl Silane Group

İsmet KAYA, Neşe ÇITAKOĞLU

Polymer Synthesis and Analysis Laboratory, Department of Chemistry, Çanakkale Onsekiz Mart University, Çanakkale, 17020, Turkey

Abstract:

Polyazomethynes witha system of conjugated in their main chain have been attractedthe attention of researchers due to their importance in many aspects[1,2]. In the recently, imine oligomers or polymers including hydroxyl group (–OH) have useful properties such as paramagnetism, semiconductivity, electrochemical cells and resistance to high energy. A series of Schiff bases were synthesized by condensation reaction of 3-aminopropyl(diethoxy)methylsilane with 3-hydroxybenzaldehyde and 4-hydroxy benzaldehyde compounds. Polymers were synthesized from Schiff bases by oxidative polycondensation. Polymers were synthesized from 2-hydroxybenzaldehyde, 2-hydroxy-3-methoxybenzaldehyde and 2-hydroxy-1-naphthaldehyde by oxidative polycondensation. Then, poly(imine)s obtained by adding 3-aminopropyl(diethoxy)methylsilane to these polymers. Sodium hypochlorite (NaOCl) was used as oxidant. Solubility tests of the synthesized Schiff bases and polymers were performed in acetonitrile, ethanol, methanol, n-hexane, ethyl acetate, acetone, THF, chloroform, DMF, DMSO. All compounds were characterized by FT-IR, UV-vis, 1H-NMR, 13C-NMR, CV and XPS analyses. In addition, thermal properties of Schiff bases and their polymers were determined by TGA, DTA and DSC techniques. DMA analyses of polymers were performed. Photoluminesans (PL) properties of the synthesized compounds were determined in solution forms in DMSO. Fluorescence measurements were carried out in various concentrated solutions to determine the optimum concentrations and obtain the maximal PL intensities. Conductivity properties of Schiff bases and polymers were examined. The number average molecular weight (Mn), weight average molecular weight (Mw) and polydispersity index (PDI) values of the synthesized compounds were determined by the size exclusion chromatography (SEC). SEM images of the synthesized polymers were obtained.

References

1. F. Doğan, İ. Kaya, K. Temizkan, Journal of Macromolecular Science Part A: Pure and Applied Chemistry2014, 51, 948-961. 2. M. Yıldırım, I. Kaya, Polymer 2009, 50, 5653-5660.

264

PO-133 Study of Thermal Degradation Kinetic of 7-amino-4-hydroxynaphthalene-2-sulfonic acid*

Fatih DOĞANa,b, Kevser TEMİZKANa, İsmet KAYAa

aPolymer Synthesis and Analysis Laboratory, Department of Chemistry, Çanakkale Onsekiz Mart University, Çanakkale, 17020, Turkey bFaculty of Education, Secondary Science and Mathematics Education, Çanakkale Onsekiz Mart University, 17100, Çanakkale, Turkey

Abstract:

Enzymatic polymerization (EP) is an alternative method to synthesize of electronically and optically active polymers. This method is known as environmentally friendly process and the reactions are carried out at ambient temperature and pressure. In addition, it offers convenient access to functional polymers and is therefore the preferred polymerization methodology. We report synthesis via horseradish peroxidase (HRP)-catalyzed oxidative polymerization of 7-amino-4-hydroxynaphthalene-2-sulfonic acid particles (AHNSA). Enzymatic polymerization of AHNSA was carried out as literature1,2. The reaction process and kinetic parameters related to the solid state decomposition of 7-amino-4-hydroxynaphthalene-2-sulfonic acid(AHNSA) particles synthesized via horseradish peroxidase (HRP)-catalyzed oxidative polymerization were investigated by thermogravimetric analysis (TG) technique at different heating rates. TG/DTG-DTA curves showed that the thermal decomposition occurred mainly in one stages. The kinetic parameters related to solid state decomposition stage of PAHNSA were calculated by using the methods based on multiple heating rates such as Kissinger, Kim-Park (KM), Tang, Flynn-Wall-Ozawa (FWO), Friedman (FR) and Kissinger-Akahira-Sunose (KAS)3. Furthermore the reaction process related to the solid state decomposition stage of PAHNSA was also determined by using integral procedure Coats-Redfern (CR) and master plots. The analysis of the so-called methods showed that the solid state decomposition mechanism of polyphenol derivatives particles in N2 went to the Dn mechanism.

*This study is supported by a grant (Project Number: KBAG-113Z587) from Scientific and Technological Research Council of Turkey.

References

1. M. E. Carbone, R. Ciriello, S. Granafei, A. Guerrieri, A. M. Salvi, Electrochimica Acta, 2014,144,174-185. 2. A. Bilici, İ. Kayaand M. Yıldırım, Biomacromolecules, 2010, 11 (10), 2593-2601.

3. F. Doğan, İ. Kaya, K. Temizkan, Journal of Macromolecular Science Part A: Pure and Applied Chemistry2014, 51, 948-961.

https://www.google.com.tr/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=0CB0QFjAA&url=https%3A%2F%2Fwww.chemexper.com%2Fchemicals%2Fsupplier%2Fcas%2F87-02-5.html&ei=1aYrVbDELMWe7gaTxIG4BA&usg=AFQjCNHzh307VGkmCrgf5PYuPoI7mSPnOA



265

PO-134 Chemical Characterization of Humic Substances Added Wood Plastic Composites

NASIR NARLIOGLU1, EYYUP KARAOĞUL1, M. HAKKI ALMA1

1KAHRAMANMARAS SUTCU IMAM UNIVERSITY, FACULTY OF FORESTRY, DEPARTMENT OF FOREST PRODUCT ENGINEERING

ABSTRACT

Wood plastic composites (WPCs) offer a wide range of advantages such as weather resistance, long service life and lower maintenance over conventional bioproducts. Even though WPCs are merits such as higher stiffness and dimensional stability lower cost and lower water uptake, it still have demerits such as lower mechanical properties such as tensile, flexural and impact strength in comparison to unfilled polyolefin itself. Interfacial adhesion between biofiber and polyolefin is an important issue in wood plastic composite processing and performance (Ashori 2008, Klyosov 2007, Lu et al. 2005). In this study, humic acid was used in MDF (Medium Density Fiber Board)/HDPE (High Density Polyethylene) composite as a coupling agent. Fourier-transform infrared (FT-IR) were used to clarify of chemical interaction between humic substances and MDF powder/HDPE composites. FTIR spectra shows that two ester bands occur between 1360 and 1075 cm-1, showing strong reaction between COOH- groups of humic acid with OH- groups of the MDF powder. In addition, humic substance spectrum strongly changed to shoulder of COO- deformation bands to 1700 cm-1 because of interaction between humic substances and MDF powder/HDPE. Keywords: Coupling agent, humic substances, wood plastic composite

REFERENCES

1. Ashori, A. (2008). Wood-plastic composites as promising green-composites for automotive industries. Review Paper. Bioresource Technology. 99, 4661–4667.

2. Hesse, M., Meier, H. & Zeeh, B. (1979). Spektroskopische Methoden in der organischen Chemie pp. 169–190. Georg Thieme Verlag Stuttgart.

3. Klyosov, A.A. (2007). Wood-Plastic Composites. John Wiley & Sons, Inc., Hoboken, New Jersey, ISBN 978-0-470-14891-4. 4. Lu, J.Z., Wu, Q. and Negulescu, I.I. (2005). Wood-Fiber/High-Density-Polyethylene Composites: Coupling Agent

Performance. Journal of Applied Polymer Science, Vol. 96, 93-102. 5. Senesi, N., D’Orazio, V. and Ricca, G. (2003). Humic acids in the first generation of EUROSOILS. Geoderma. 116, 325-344.

266

PO-135

GC/MS Analysis of Essential Oil of Salvia Fruticosa M. and Sideritis Perfoliata L.

Ertuğrul ALTUNTAŞa, Eyyüp KARAOĞULa, BETÜL ÇELİKa, M. Hakkı ALMAa aKahramanmaraş Sutcu Imam University, Faculty of Forestry, Department of Forest Industrial Engineering, TR-46400,

Kahramanmaraş, Turkey Abstract:

Sage is commonly consumed as a tradition herbal tea in Turkey. Sage is known as “adacayı” and is commonly consumed as teas which used in this study were obtained from Hatay in Turkey. In this study was researched that obtained from two different sages of Salvia fruticosa M. and Sideritis perfoliata. L. Water distillation method and microwave extraction methods were tried to obtain essential oils. Components of Essential oils obtained from water distillation and microwave extraction methods were analysed by GC/MS. In analysis of essential oil of Salvia fruticosa M. was identified primary organic compounds as α- Pinene, Camphene, α- Pinene, α- Myrcene, D-Limonene, Eucalyptol, Borneol. Besides analysis of essential oil of Sideritis perfoliata L was identified organic compounds as (+-)α- Pinene, Camphene, Β- Pinene, α- Myrcene, D-Limonene, Eucalyptol, Borneol , Bicyclo..

267

PO-136 Synthesis of Oil-Based Graft Copolymers via the Combination of Ring Opening

Polymerization and Free Radical Polymerization*

Abdulkadir Allıa, Yurdagül Arıa, Sema Allıa and Muharrem Gökçenb

aDepartment of Chemistry,Faculty of Art and Science, Düzce University, TR-81620, Düzce, Turkey bDepartment of Physics,Faculty of Art and Science, , Düzce University,TR-81620, Düzce, Turkey

Abstract:

Oil / oily acid macroperoxides can initiate the free radical polymerization of vinyl monomers, leading to graft copolymers [1]. A one-step process has been successfully used for the synthesis of block/graft copolymers using different techniques, which thus has several advantages over other popular methods [2].

Graft copolymers having the structure of poly(linoleic acid)-g-poly(t-butyl methacrylate),poly(linoleic acid)-g-poly(t-butyl methacrylate)-g-poly(ε-caprolactone) were synthesized from polymeric linoleic acid peroxide (PLina)possessing peroxide groups in the main chain by the combination of free radical polymerization of t-butyl methacrylate and ring-opening polymerization of ε-caprolacton in one-step. The principal parameters such as monomer concentration, initiator concentration, and polymerization time that affect the one-step polymerization reaction were evaluated. The graft copolymers obtained were characterized by 1H NMR, GPC, TGA and DSC techniques.

Scheme1.Reaction design of the one-step polymerization of styrene ε-caprolactone initiated by polymeric linoleic acid peroxide.

* This study is supported by a grant (Project Number: 110T884) from Turkish Scientific Research Council, TUBİTAK.

References

1. A. Allı, B. Hazer, Jour Am Oil Chem Soc, 2011, 88, 255-263. 2. A. Allı, S. Allı, C. R. Becer, B. Hazer, Jour Am Oil Chem Soc, 2014, 91, 849-858.

268

PO-137

The Effects of Transplant Age on Element Content Determined by Wavelength-DispersiveX-ray Fluorescence Spectrometry of Broccoli(Brassica oleracea L. var. italica)

Cultivars

Faika YARALI1, HalukÇağlar KAYMAK2, İsmail GÜVENÇ1, Ali GÜROL3

1Department of Horticulture, Agriculture Faculty, Kilis 7 Aralık University, TR-79000,Kilis, Turkey 2Department of Horticulture, Agriculture Faculty, Atatürk University, TR-25070, Erzurum, Turkey

3Department of Physics,Science Faculty, Atatürk University, TR-25070, Erzurum, Turkey

[email protected]

Abstract The aim of this study was to determine not only the effects of transplant age on element content of broccoli (Brassica oleracea L. var. italica) cultivars but also the applicability of a quantitative WDXRF (Wavelength-Dispersive X-ray Fluorescence) method, for determination of minerals in broccoli specimens. This experiment was conducted during 2013 - 2014 to find out the effects of transplant age on element content of different broccoli (Brassica oleracea L. var. italica) cultivars ( ‘Jade F1’, ‘Monaco F1’, ‘Monopoly F1’).We have found

that major elements; namely K, Cl, P, S, Ca; minor elements; Fe, Cu, Co, Zn, Mn, Se, Cr, Br, and a few trace elements; Al, Ni, Ge, As. The obtained major, minor and trace element concentrations range from1,1 to 49,7µg/cm2; 0,25 to 2,4µg/cm2and 0,23 to 52,6 µg/cm2, respectivelyfor all years.And also, this rapid method has been found to be a reliable technique for analyzing the element content in broccoli. At the end of this work, it was clearly said that element content of broccoli cultivars was affected by transplant age andwavelength-dispersive X-ray fluorescence spectrometry (WDXRF) could be used for the analysis of element contents of broccoli and other vegetables. Keywords: Broccoli, Transplant age, Elemental Analyses, Wavelength-Dispersive X-ray FluorescenceSpectrometry


269

PO-138 Synthesis and Characterization of pyrimidine-containing Schiff Base Derived From o-

Vanillin and Its Metal Complexes*

Mehmet Emin HACIYUSUFOĞLUa, Mehmet SÖNMEZb, Benan KILBAŞc, Zülbiye Önald aDepartment of Food Technology, Akçakoca Vocational School, DüzceUniversity, TR-81650,Düzce,Turkey

bDepartment of Chemistry, Faculty of Science and Arts, Gaziantep University, TR-27310,Gaziantep,Turkey cDepartment of Chemistry, Faculty of Art and Science, Düzce University, TR-81620, Düzce, Turkey

dDepartment of Chemistry, Faculty of Science, Erciyes University, TR-38000 Kayseri,Turkey

Abstract: Pyrimidin ring uracil, thymine and cytosine are obtained from the nucleic acid hydrolysis.pyrimidines ring is also found in vitamin B1,barbituric acid and its severalderivatives such as Veranal which are used as hypnotics. Several pyrimidine-containing pyrimidines shows strong activity such as antibiotics, antitumor, antimicrobial, antimalarial, cardiotonic, antihipersensitive, antiprotozoal, antiepileptic drugs, anesthetics, analgesics, anti-HIVtherefore took place in the medical and pharmaceutical fields1.The compound of vanillin shows flavor and aroma properties and its synthetic compounds used as additives in foods, beverages, and pharmaceuticals. Novel pyrimidine Schiff base ligand obtained by condensation of o-vanillin with N-aminopyrimidine-2-thione and its metal complexes.The biological activity of these compounds is reported2.In the study, pyrimidine-containing Schiff base ligand was preparedby condensing 1-amino-5-(4-methoxybenzoyl)-4-(4-methoxyphenyl)pyrimidin-2(1H)-one with o-vanillin. The complexes were formed byreacting ligand and the metal acetates of Co(II), Ni(II), Cu(II) and Pd(II) in methanolto get a series of mononuclear complexes. The characterization of ligand andmetal complexes were carried out by elemental analyses, conductivity measurements, magnetic susceptibility data, IR, UV-vis, NMR, and LC-MS spectral data.

O

N

N

O

O

N

H3CO

H3CO

O

N

N

O

O

N

OCH3

OCH3M

OCH3

H3CO

Figure1.Proposed structure of the M :[ Co(II), Ni(II), Cu(II) and Pd(II)] complexes

*This study is supported by a grant (Project Number:…) from Scientific Research Projects Committeeof Duzce University.

References

1. R. Dudhea, P.K. Sharmab, P. Vermae, A. Chaudhary, J. Adv. Sci. Res., 2011, 2(3), 10-17. 2. M.Gülcan, M. Sönmez, Phosphorus, Sulfur, and Silicon,2011, 186, 1962-1971.

270

PO-139 Synthesis of Some Heterofunctionalized Penicillanic Acid, Norfloxacine and Ciprofloxacine Derivatives and Investigation of Their Biological Activities*

Serpil Demircia, Meltem Yolalb, Arif Mermerb, Neslihan Demirbasb, Ahmet Demirbasb

aGiresun University, School of Applied Science, Department of Crop Production and Technology, Giresun,Turkey b Department of Chemistry, Faculty of Arts and Sciences, Karadeniz Technical University, Trabzon, Turkey

e-mail: [email protected] Abstract:

The development of drug resistance is fast becoming a worldwide concern with rapid increases in multidrug resistant bacteria. In addition, there has been a continual battle between humans and the multitude of microorganisms that cause infection and disease, such as, bubonic plague, tuberculosis, malaria, and more recently, the human immuno deficiency virus, acquired immuno deficiency syndrome pandemic, have affected substantial portions of the human population, causing deaths [1-3].

In view of these findings this study, as a part of our ongoing study on the synthesis of bioactive hybrid molecules, we aimed to obtain new penicillanic acid, norfloxacine and ciprofloxacine derivatives containing azole moieties in a more environment-friendly way.

*Acknowledgement the financial support was provided by TUBITAK (Project Number:111T427)

References 1. Raparti, V. Chitre, K., Bothara, V. Kumar, S. Dangre, C. Khachane, S. Gore, B. Deshmane, Eur. J. Med.

Chem., 2009, 44, 3954–3960. 2. Demirci S., Basoglu S., Arif B., Demirbas N., Med Chem Res, 2013, vol. 22, pp. 4930–4945. 3. Demirci S., Demirbas A., Ulker S., Bozdeveci A., Karaoglu S.A., Demirbas N., Arch. Pharm. Chem. Life Sci., 2014, vol. 347, pp. 200–220.

271

PO-140 A simpleandSensitiveColorimetricand ‘‘turn-on’’ FluorometricSensorforArsenicSpecies

in Aqueous Media EsraŞena, SerdarAtılgana

aDepartment of Chemistry,Faculty of Art and Science.SüleymanDemirelUniversity32000 Isparta,Turkey Arsenic is considered as a ubiquitous toxicant released through natural and industrial sources causing many health

problems, including cancer of the skin and internal sites, diseases of the peripheral vasculature and cardiovascular system, and dysfunctions of the endocrine, nervous, and reproductive systems.1 These human health risks, arising from arsenic species, have been associated with the inorganic form of the arsenics. The arsenic induced toxicity arising from the inorganic form of arsenic is assessed based on the oxidation states of the inorganic arsenics. Inorganic trivalent arsenite (AsIII), and pentavalent arsenate (AsV) salts, the most common arsenics forms in the environment, exhibit the highest toxicity, respectively, followed by the moderately toxic organic forms of arsenics.2 Accordingly, a great deal of effort has been devoted to detect these arsenic species, particularly, in drinking water. Current techniques for detection of each and every one of arsenic species based on either analytical procedures such as Gutzeit method or spectrometric methods such as ICPMS and AAS are time consuming and accomplished through a series of enrichment steps. Thus, the development of highly selective sensors for real-time monitoring of arsenic species, particularly in aqueous media, is an important goal.

A colorimetric and “turn-on” fluorescent chemosensorbased on, a robust and handy, formyl-p-cresol derivative is presented for real-time detection of toxic arsenic species in aqueous media. It displays a remarkable selectivity toward the detection of most toxic arsenic species over biologically relevant anions with Lewis acid-base interaction strategy.3

References

1. a) V. D. Martinez, E. A. Vucic, M. Adonis, L. Gil and W. L. Lam, Molecular Biology International, 2011, 11; b) M. M. Moriarty, I. Koch, R. A. Gordon, K. J. Reimer, Environ. Sci. Technol., 2009, 43, 4818.

2. a) C. Voegtin, J. M. Johnson, J. Biol. Chem, 1930, 89, 27; b) N. A. Rey, O. W. Howarth, E. C. J. Pereira-Maia, Inorg. Biochem., 2004, 98, 1151.

3. M. Baglan, S. Atılgan, Chem. Commun., 2013,49, 5325-5327

Figure1:Fluorescenceemissionspectra of dye (10 µM) in H2O/ CH3CN(1:9, v/v) aftertheaddition of differentconcentrations of As3+ (0-75 equiv.)

Figure 2:Thefluorescenceintensitychange of thesolution of dye (10 μM) at 530 nmwith100mM of a competing metal followedbyadditionof 100mM As3+ in 1:9 H2O/CH3CN

272

PO-141 AIE Active Tetraphenylethene: Rapid and Selective Fluorescent “turn-on” Sensor for

Fluoride Ion in Aqueous Media

Mine Binecia, SerdarAtılgana

aDepartment of Chemistry,Faculty of Art and Science. SüleymanDemirel University 32000,Isparta,Turkey Anions play key roles in a wide range of biological and chemical processes.1 In this regard;the detection of anions is, in particular, the focus of interest. Although, various detection techniques, such as ion chromatography and capillary electrophoresis are used in conventional analytical methods,2 fluorescence technique appear to be particularly important due to its simplicity, high detection sensitivity, low detection limit and low cost.3 Among the various important anions, fluoride is one that has been attracting more interest because of its considerable significance for health4 and environmental issues.5 Generally, fluoride deficiency has been linked to increased risk of dental carries.4 On the other hand, the elevated level of fluoride concentration leads to fluorosis and urolithiasis.4 A further importance of fluoride lies in the detection of nerve gases and uranium wastes.5 As a consequence of the dependence of fluoride ion concentration on the aforementioned issues, it is important to develop highly selective, sensitive and rapid fluorescent sensor to determine the accurate level of fluoride ion.

In this Study, Pyridine functionalized derivative of tetraphenylethene was reported for highly selective detection of fluoride ion in aqueous media. Rapid “turn-on” fluorescence signalling in the presence of micromolar quantities of fluoride ion was attributed to the aggregation of the tetraphenylethene units due to the decrease in solvolysis caused by the ion exchange.

F

i

g

u

r

e

References

1. F. P. Schmidtchen, M. Berger, Chem. Rev. 1997, 97, 1609 2. J. P. Hutchinson, C. J. Evenhuis, C. Johns, A. A. Kazarian, M. C. Breadmore, M. Macka, E. F. Hilder, R. M. Guijt, G. Dicinoski, P.

R. Haddad, Anal. Chem. 2007, 79, 7005 3. R. Martínez-Máñez, F. Sancenón, Chem. Rev. 2003, 103, 4419 4. K.L. Kirk, Biochemistry of theHalogensandInorganicHalidesPlenumPress, New York, 1991, 58 5. T. W. Hudnall, C.-W. Chiu, F. P.Gabbai, Acc. Chem. Res., 2009, 42, 388

Figure1:Fluorescenceemissionspectra of dye (200 µM) in CH3CN/H2O (1:99, v/v) aftertheaddition of differentconcentrations of F- (0-15 equiv.)

Figure 2:Thefluorescenceintensitychange of thesolution of dye(200 μM) at 470 nmwith 3.0 mM of a competing metal followedbyadditionof 3.0 mM F- in 1:99 CH3CN/H2O

273

PO-142 Antioxidant and Cytotoxic Activity of Ganoderma resinaceum Boud.

Mehmet Emin DURUa, Selçuk KÜÇÜKAYDINa, Aziz TÜRKOĞLUb, Gülsen TELa, Mehmet ÖZTÜRKa.

aMuğla Sıtkı Koçman University, Faculty of Science, Department of Chemistry48121 Kötekli Muğla, Türkiye

bMuğla Sıtkı Koçman University, Faculty of Science, Department of Biology48121 Kötekli Muğla, Türkiye

Abstract: Mushrooms are considered, all over the world, valuable health foods since they are poor in calories, fat and essential fatty acids, and rich in proteins vitamin and minerals [1-3].In previous studies various biologic activities such as antioxidant, antibacterial, antifungal, immunomodulatory, antiviral, anti-inflammatory, cytotoxic, antiaromatase, and anticholesterole activities of mushrooms investigated. In this study, antioxidant and cytotoxic activity of Ganoderma resinaceum analyzed.G. resinaceum is a basidiomycete fungus belonging to the order Polyporales and the family Ganodermataceae.G. resinaceum was collected in January 2015 from Fethiye(Muğla), in the South-western part of Turkey. Dried mushroom samples was extracted by hexane, methanol and distilled water respectively.Antioxidant activities of the extracts were determined by using the methods: β-Carotene linoleic acid bleaching assay, DPPH radical scavenging activity, ABTS cation radical scavenging activity, CUPRAC (Cupric ion reducing antioxidant capacity) and metal chelating activity method.The cytotoxic activity screening of the extract was performed using MCF-7 (breast), human tumor cell lines.In DPPH radical scavenging, ABTS•+ scavenging and and β-carotene linoleic acid bleaching assay the methanol extract of G. resinaceum showed the best activity 74,78±0,81%, 91,91±0,22% and 91,15±0,15% at 400 μg/mL concentration, respectively while in CUPRAC assay and metal chelating activity, the water extract of this mushroom exhibited higher activity.In Cytotoxicity assay, extracts of G. resinaceum (hexane, methanol and water) showed inhibition, %61,57, %54,31 and %35,7 at 50 μg/mL concentration respectively. *This study is supported by a grant (114Z550) from The Scientific and Technological Research Council of Turkey (TÜBİTAK).

References

1. A. Türkoğlu, M.E. Duru, N. Mercan, İ. Kıvrak, K. Gezer, Food Chem. 101, (2007), 267–273. 2. G. Tel, M. Apaydın, M.E. Duru, M. Öztürk, Food Anal. Method, 5, (2012), 495–504. K. Gezer, M.E. Duru, I. Kıvrak, A. Türkoğlu, N. Mercan, H. Türkoğlu, S. Gülcan, African J. Biotechnol. 5, (2006), 1924–1928.

274

PO-143 Metal Oxide Nanoparticles: An Effective Heterogenous, Recyclable Catalyst for Synthesis

of Thio Schiff Bases* Aslıhan DALMAZa,Mesut ÖZDİNÇERb, Elif AYDINLIa, Sefa DURMUŞa

aDepartment of Chemistry,Faculty of Arts and Sciences, Düzce University, TR-81620, Düzce, Turkey bDepartment of Composite and Material Technology, Faculty of Technology,Düzce University, TR-81620, Düzce, Turkey

Abstract: In recent years, the discovery of the metal oxide nanoparticles have excellent properties of these particles has pointed out the attention of researchers[1]. Especially metal oxide based nanoparticles have attracted area in organic synthesis due to their high catalytic activity, reusability, environmental compatibility and non-toxic properties. On the other hand, thio Schiff bases have important class of bioactive compound in the field of pharmacological properties[2] such as antimicrobial, antifungal, anticancer and antitumor. In addition, these moieties have also been utilized in industry as antioxidants, corrosion inhibitors[3], vulcanization accelerators and as dopants in LED devices. The aim of this study issynthesized thio Schiff bases by using some metal oxide nanocatalysts. Because of catalysis by nanoparticles seems to be an attractive approach to the synthesis of thio Schiff bases due to the large and reactive nanoparticles surfaces, higher potential for selectivity, which may enable reactions under milder conditions, easier isolation products, shorter reaction time, gave excellent yield and possibility of reusing the catalyst.

Scheme1.Synthesis of thio Schiff bases using heterogenous nanocatalysts.

*This study was supported by the Düzce University Scientific Research Projects Fund.

References

1. Tarannum S., Ahmed N., Siddiqui Z. N., Catalysis Communications, 2015,66, 60–66. 2. Gupta B. M., Jhaumeer-Laulloo S., Soukhee N., Allıbacus A., Shıboo V., J. of Coordination Chem., 2007,60, 1335-1343. 3.Kosari A., Momeni M., Parvizi R., Zakeri M., Moayed M.H., Davoodi A., Eshghi H., Corrosion Science, 2011,53, 3058-3067.

275

PO-144 Comparative Studies on Conventional & Microwave Synthesis of 2-Aryl Benzothiazoles

and Their Antibacterial Activities*

Aslıhan DALMAZa,Mesut ÖZDİNÇERb, Elif AYDINLIa, Sefa DURMUŞa aDepartment of Chemistry,Faculty of Arts and Sciences, Düzce University, TR-81620, Düzce, Turkey

bDepartment of Composite and Material Technology, Faculty of Technology,Düzce University, TR-81620, Düzce, Turkey

Abstract: Benzothiazoles are fused membered ring which contain the heterocycles bearing thiazole[1]. Sulphur and nitrogen atoms constitute the core structure of thiazole and biological active compounds. Benzothiazole moites are part of compound used as a pharmacologically agent with a wide variety of biological activities[2]such as antimicrobial, antifungal, antianalgesic and antitumor properties. In addition, some of these compounds exhibit nonlinear optical, luminescent/fluorescent properties[3], and have therefore found applications in designing sensor molecules of specific interest.In this study, 2-aryl benzothiazole derivatives were synthesized by condensation of 2-aminothiophenol with aromatic aldehydes under both microwave irradiation and convertional heating.The synthesized compounds were evaluated in vitro antibacterial activity against gram positive and gram negative bacteries by disc diffusion method.

Scheme1.Proposed formation mechanism of 2-arylbenzothiazole derivatives.

*This study was supported by the Düzce University Scientific Research Projects Fund.

References

1. Khosravi K., Kazemi S., Chinese Chem. Letters, 2012, 23, 61–64. 2. Yadav P. S., Devprakash, Senthilkumar G. P., Inter. J. of Pharm. Sci. and Drug Research 2011, 3, 01-

07. 3. Echevarria L., Moreno I., Camacho J., Salazar M. C., Hernández A., Spec. Chim. Acta Part A: Mol. and

Biomol Spect., 2012, 97, 274–276.

276

PO-145 Synthesis and Characterization of Pyrimidine-containing Schiff Base Derived from O-

Vanillin and Its Metal Complexes

Mehmet Emin HACIYUSUFOGLUa, Mehmet SÖNMEZb, Benan KILBAŞc, Zülbiye Önald

aDepartment of Food Technology, Akçakoca Vocational School, DüzceUniversity, TR-81650,Düzce,Turkey bDepartment of Chemistry, Faculty of Science and Arts, Gaziantep University, TR-27310,Gaziantep,Turkey

cDepartment of Chemistry, Faculty of Art and Science, Düzce University, TR-81620, Düzce, Turkey dDepartment of Chemistry, Faculty of Science, Erciyes University, TR-38000 Kayseri,Turkey


Abstract: Pyrimidin ring uracil, thymine and cytosine are obtained from the nucleic acid hydrolysis.pyrimidines ring is also found in vitamin B1,barbituric acid and its severalderivatives such as Veranal which are used as hypnotics. Several pyrimidine-containing pyrimidines shows strong activity such as antibiotics, antitumor, antimicrobial, antimalarial, cardiotonic, antihipersensitive, antiprotozoal, antiepileptic drugs, anesthetics, analgesics, anti-HIVtherefore took place in the medical and pharmaceutical fields1.The compound of vanillin shows flavor and aroma properties and its synthetic compounds used as additives in foods, beverages, and pharmaceuticals. Novel pyrimidine Schiff base ligand obtained by condensation of o-vanillin with N-aminopyrimidine-2-thione and its metal complexes.The biological activity of these compounds is reported2.In the study, pyrimidine-containing Schiff base ligand was preparedby condensing 1-amino-5-(4-methoxybenzoyl)-4-(4-methoxyphenyl)pyrimidin-2(1H)-one with o-vanillin. The complexes were formed byreacting ligand and the metal acetates of Co(II), Ni(II), Cu(II) and Pd(II) in methanolto get a series of mononuclear complexes. The characterization of ligand andmetal complexes were carried out by elemental analyses, conductivity measurements, magnetic susceptibility data, IR, UV-vis, NMR, and LC-MS spectral data.

O

N

N

O

O

N

H3CO

H3CO

O

N

N

O

O

N

OCH3

OCH3M

OCH3

H3CO

Figure1.Proposed structure of the M :[ Co(II), Ni(II), Cu(II) and Pd(II)] complexes

References

1. R. Dudhea, P.K. Sharmab, P. Vermae, A. Chaudhary, J. Adv. Sci. Res., 2011, 2(3), 10-17. 2. M.Gülcan, M. Sönmez, Phosphorus, Sulfur, and Silicon,2011, 186, 1962-1971.


277

PO-146 Synthesis, Characterization and Electrochemical Study A NewHeterocyclic Schiff Base

and Its Metal Complexes: [Co(II), Ni(II), Cu(II) and Pd(II)]

Mehmet Emin HACIYUSUFOGLUa, Mehmet SÖNMEZb, Benan KILBAŞc, Abdulkadir LEVENTd

aDepartment of Food Technology, Akçakoca Vocational School, DüzceUniversity, TR-81650,Düzce,Turkey bDepartment of Chemistry, Faculty of Science and Arts, Gaziantep University, TR-27310,Gaziantep,Turkey

cDepartment of Chemistry, Faculty of Art and Science, Düzce University, TR-81620, Düzce, Turkey dBatman University, Health Services Vocational College, TR-72100 Batman,Turkey


Abstract: N donor containing compounds play an important role in analytical chemistry. N-containing heterocyclic compounds and their metal complexes for various fields have been studied. Such compounds are known to play an important role in biological systems. Also, this type of ligands and their metal complexes have been searched use in catalysis for oxygenation and oxidation of organic compounds and electrochemical reduction reactions.Because of this feature can be used as a key model in biological systems1,2.In the study, the synthesis, spectroscopic characterization and electrochemical properties of a new heterocyclic Schiff base and its Co(II), Ni(II), Cu(II) and Pd(II) complexes were studied. All of the compounds were characterized with UV-Vis, IR, NMR, LC-MS, electrolytic measurement and magnetic susceptibility techniques. The cyclic voltammograms of the ligand and the complexes are also discussed.

O

N

N

O

O

N

H3CO

H3CO

O

N

N

O

O

N

OCH3

OCH3M

Figure1.Proposed structure of the complexesFigure2. Cyclicvoltammograms of 1x10-3mol L-1

ligand (HL) compound at glassy carbon electrode; A: scan rate at 100 mV s-1, B: different scan rates

References

1. T. Okada, K. Katou, T. Hirose, M. Yuasa, I. Sekine, J. Electrochem. Soc., 1999, 146, 2562. 2. M. Sönmez, M. Çelebi, A. Levent, İ. Berber and Z. Şentürk, J. Coord. Chem.,2010 63, 848.


278

PO-147 Preparation of the Micronize Materials for the Water-Based Paint*

EsvetAkbaşa and Aziz Sökmena

aYuzuncuYil University, Department of Chemistry, 65080, Van, Turkey. [email protected]

Abstract

Paints, surface protection or for decorative purposes can be applied to various surfaces forming a thin film on chemical compositions.The content of all paints are1-binders, 2- pigments, 3-extenders, 4-additives and fillers 5- chemical agents and assistants, 6- solvents, 7- special chemicals. The additives and fillers are added in paint to adjust the opacity, dye density, smoothness and cost. Mostly as a filler kaolin, barite, talc, calcite, zinc phosphate, zinc oxide, dolomite, iron powder and aluminum silicate used.In this study, acidic micronize pumice stone was used as filling material. Acidic pumice stone contains an average of %60-70 Si0₂, % 13-15A1₂0₃, %1-3 Fe₂0₃, %1-2CaO, % 1-2 MgO, %7-8 Na₂O +K₂O. The chemical composition of pumice stone provides substantial resistance against abrasion and high temperature. Pumice stone is an average of 5.5 Mohs hardness. This value makes it extra important to use the pumice stone in the paint industry.When used micronize pumice stoneat the paint, increased the quality and extended its life. Abrasion, adhesion,application,colour, drying time,grindometer, gloss, moisture measurement,opacity,specific gravity, density, temperature, pH & conductivity, viscosity tests were performed to final products. As a result, when the last product has been applicatedexterior as a smooth and texture, successful results was obtained. *This study is supported by a grant (Project Number YNL-MRK003) from Scientific Research Projects Committee of YuzuncuYil

University and (Project Number 0282.STZ.2013-2) from BilimSanayive Teknoloji Bakanlığı SAN-TEZ Programı.

http://www.hedefkimya.com/etic_urunler.asp?id=1045














279

PO-148 Antimicrobial Agents in Textile Industry

Aslı Demira, Tülay Gülümsera, Esen Özdoğana e-mail: [email protected]

aDepartment of Textile Enginerring,Faculty of Engineering,Ege University, TR-35100, İzmir, Turkey

Abstract: Textiles are polymeric materials and susceptible to be attacked by various harmful microorganisms present in the atmosphere and environment such as bacteria and fungi. Therefore, the bacterial adherence on textile fabrics is an important field of study to prevent the growth and further proliferation of these harmful organisms. These microorganisms are found almost everywhere in the environment and can multiply quickly when basic requirements, such as moisture, nutrients and temperature are met (1,2). Various methods, depending on the particular active agent and fiber type, have been developed or are under development to confer antimicrobial activity to textiles. For synthetic fibers, the antimicrobial active agents can be incorporated into the polymer prior to extrusion or blended into the fibers during their formation. The conventional exhaust and pad–dry–cure processes have been used for antimicrobial finishing on natural as well as synthetic (4). As a consequence of their importance, the number of different antimicrobial agents suitable for textile application on the market has increased dramatically. These antimicrobial agents differ in their chemical structure, effectiveness,method of application, and influence on people and the environment as well as cost (3). Several major classes of antimicrobial agents are used in the textile industry such as Metals and Metal Salts, Quaternary ammonium compounds, PHMB(polyhexamethylene biguanides), Triclosan, Chitosan, Regenerable N-halamine and Peroxyacid.(2) An antimicrobial present in clothing, healthcare fibrous product, and home textiles may contact to an individual’s skin or it may affect the useful organisms found in the surrounding environmentnegatively. Therefore, the selection of antimicrobial agents is of great importance.

References

1. V.Bajpai, S.Bajpai, M. K. Jha, A., Journal of Environmental Research And Development, 2011, 3,666. 2. Y.Gao1,R.Cranston, Textile Research Journal, 2008, 78(1): 60–72 3. W. D. Schindler and P. J. Hauser, Chemical Finishing of Textiles, Woodhead Publishing, England, 2005. 4. Mao, J. W., and Murphy, L., AATCC Review, 2001, 1, 28–31.

280

PO-149 Methods Used for the Surface Modification of Textiles

EsenÖzdoğan,aAslıDemira, TülayGülümsera, e-mail: [email protected]

aDepartment of Textile Enginerring,Faculty of Engineering,Ege University, TR-35100, İzmir, Turkey

Abstract: Modification is defined as a limited change in any material. Surface modification provides some physical and/ or chemical changes on the surface of the materials without affecting their bulk properties. With these modification methods which are classified as chemical, physicochemical and biochemical some properties can be enchanged or given single or multi-functions to the textile materials for various applications.

Chemical modification of textiles is carried out with application and reaction of any kind of chemical agent to the material. If the textile material is exposured to the chemicals long time, color, mechanic and chemical properties of the material can be changed(1,2).

Because of disadvantages of chemical modifications, researchers tend to improve and accessibility of physicochemical

modifications. Corona discharge, heat treatments, plasmas, UV and - radiations electron or ion bombardment, ozon can be given as an example for physicochemical (3,4).

Another alternative method is biochemical modification with enzymes. Enzymes are used in desizing (amylase) for the first time in textile industry and now they can be used in many applications from pretreatment to finishing of both synthetic and natural fibres(5).

References

1. Matthews S.R., Plasma AidedFinishingof Textile Materials Fiber And Polymer Science North Carolina State University, Doctoral Thesis, 2005

2. Chan C. Polymer Surface Modification and Characterization, Hanser/Gardner Publications, Inc., New York, 1994

3. Yip J., Chan K., Sin K. M., Lau K. S., Comprehensive Study of Polymer Fiber Surface Modifications Part 1: High-fluence UV-excimer-laser-induced Structures, Polymer International 53: 627-633 (2004).

4. Wakida, T., Tokuyama, T., Lee, Muncheul J., Jeong H. Ozone Gas Treatment of Wool and Silk Fabrics Textile Research Journal, Jul 2004

5. Gübitz G. M., Cavaco-Paulo A., New Substrates for Reliable Enzymes: Enzymatic Modification of Polymers, Current Opinion in Biotechnology 2003, 14:577–582).


281

PO-150 Reusebility of the Laccase Incorporated Nanofiber Based Biocomposite Generation with

and without Cyclodextrin Addition.

Hasan Basri Savasa, Mehmet Fatih Canbolatb, Fatih Gultekina

a. SüleymanDemirel University Faculty of Medicine Department of Medical Biochemistry. Isparta. Turkey. b. SüleymanDemirel University Faculty of Textile Engineering. Isparta. Turkey.


Abstract:

Laccase is an oxidative enzyme and consist of multinuclear copper. It has a glycoprotein form and wide industrial use. It is used in the beverage stabilization, juices, wines and beers in removal of the phenol derivative, in the dyeing and printing of textile products, in the pulp and paper industry for the bleaching process.This study aimed to show the adding of laccase to the fabric sample was created with the nanofiber technology, tried different techniques and keep it stable by fixing the enzyme and long-term activity continued after six months.Groups and placement of laccase enzyme methods are shown respectively; 1. Enzymes encapsulated. 2. Gama CD (cyclodextrin) encapsulated. 3. polycaprolactone (PCL). 3. Enzyme between layers. (Placing of the enzyme with sandwiched up form between the nanofiber layers obtained by using the polycaprolactone (PCL) polymer). 4. Gama CD PCL layered. 5. Gama CD-IC (cyclodextrin inclusion complex) encapsulated. Acetate buffer was used to maintain a constant pH of the medium. ABTS (2,2'-azino-di-3-ethyl-benzo-thiazoline-sulfonate) (Sigma Aldrich) was used as a substrate. Acetate buffer was used as a blank. ABTS gives the maximum absorbance at 420 nm. The laccase activity was calculated on the basis of the change in absorbance by reaction between laccase and ABTS, shown in spectrophotometer at 420 nm.Thepresence of laccase activity was observed in the all five samples and activity of laccase was calculated. Laccase activities were respectively, for samples in five groups; 11.47, 12.42, 9.64, 14.8, 24.4 as measured U/mg.This study indicates that the addition of the laccase enzymes to fabrics by nanofiber technology can show long-term efficacy. Keywords: laccase, nanofibers. References 1. MayeraA.M.,StaplesR.C.. Laccase: newfunctionsfor an oldenzyme. Phytochemistry 60 (2002) 551–565.

282

PO-151 Experimental Application of Kefir and Acetylsalicylic on Antioxidant Activity in Rats.

BetulMermiCEYHANa, Hasan BasriSAVASa, Altug SENOLb, GürselACARTURKc

a. SüleymanDemirel University Faculty of Medicine Department of Medical Biochemistry. Isparta. Turkey. b. SüleymanDemirel University Faculty of Medicine Internal Medicine Department. Isparta. Turkey.

c. AfyonKocatepe University. Faculty of Medicine Internal Medicine Department.Afyon. Turkey. [email protected]

Abstract In living organisms, oxidant and antioxidant systems are in a balance. Reactive products formed continuously by exogenous and endogenous sources are rendered harmless by the antioxidant system. (Burçak G. 2004). In the present study, we aimed to investigate the effects of kefir on oxidant-antioxidant systems in rat serum.32 male, Wistar albino rats weighing 156-246 gr obtained from SuleymanDemirel University, Experimental Animals Laboratory were included in the study. Rats were divided into four groups based on kefir application;The control group (n = 8) While fed through the standard for eight days, at the same time once daily, 2 ml of saline was given by oral gavage in the morning hours 9-10 (SF).ASA group (acetylsalicylic acid) (n = 8): While fed through the standard for eight days, at the same time once daily, 2 ml of saline by oral gavage in the morning hours 9-10 (SF) was given. 200 mg / kg ASA was given by oral gavage in eighth day and they were sacrificed three hours later. Kefir group (n = 8): While fed through the standard for seven days, at the same time once daily, 2 ml of kefir was given by oral gavage in the morning hours 9-10. 2 cc SF was given on the eighth day and they were sacrificed. Kefir + ASA (n = 8): While fed through the standard for seven days, at the same time once daily, 2 ml of kefir was given by oral gavage in the morning hours 9-10. 200 mg / kg ASA was given on the eighth day and they were sacrificed.Total antioxidant status (TAS) and total oxidant status (TOS) levels were determined through Erel method by a biochemical auto-analyser equipment (Beckman Coulter AU 5800. USA), using a commercial kit (Rel Assay Diagnostic Turkey). Oxidative stress index was calculated using the formula (OSI) = TOS/TAS. Statistical analyses were carried out using SPSS package program. <0.05 was regarded as statistically significant. When TAS, TOS and OSI values were compared by parametricAnova test, Despitesignificantly increased antioxidant activity in all three groups according to the control group,the highest antioxidant activity increasing was in the group given only kefir References

1. Burçak G and Andican G. Oksidatif DNA hasarıveyaşlanma (oxidative DNA damage and aging) Cerrahpaşa J Med 2004; 35:159-169.

283

PO-152 Electrochemical Synthesis and Electrochromic Application of a Novel Polymer Based on

Carbazole

Aysel AydınKocaerena aDepartment of ElementaryEducation, Faculty of Education, Süleyman Demirel University, TR- 32260, Isparta, Turkey

Abstract: The compound containing carbazole andthiophene, named as B1 was synthesized with 4-(9H-carbazol-9-yl) phenoland 3,4-dibromo thiophene. Additionally, the electrochemical polymer of B1was synthesized and coated onto an ITO–glass surface via electrochemical oxidative polymerization. The electrochemical synthesis of the polymer was performed both in 0.05 M LiClO4 supporting electrolyte in AN/BF3EtE (1:1, v/v) and an AN/LiClO4 solvent/electrolyte solution. The spectroelectrochemical and electrochromic properties of this polymer were also investigated for two electrolyte solution systems. The switching ability of this polymer was measured as the percent transmittance (%T) at its point of maximum contrast. According to the electrochromic measurements, the synthesized polymer had a blue color when it was oxidized, and also when it was reduced, it had a transparent color. Additionally, redox stability measurements indicates that the polymer had a high stability and it could be used to produce new polymeric electrochromic devices and also, it can be said that it is a good candidate for electrochromic devices (ECDs) applications.

Scheme1.Spectrochemistry and color changes of the polymers in (a) 0.05 M AN/LiClO4 solvent/electrolyte solution, (b) LiClO4

supporting electrolyte in AN/BF3EtE (1:1, v/v).

References

1. A. Aydın, İ. Kaya, Electrochim. Acta, 2012, 65, 104. 2. W.T. Neo, Q. Ye, T.T. Lin, S.J. Chua, J. Xu, Sol. Energy Mater. Sol. Cells2015, 136, 92. 3. A. Aydın, İ. Kaya, J. Electroanal. Chem.2013, 691, 1.

284

PO-153 Efficiency of Wet and Dry Digestion for Determination of Selected Metals from Coal By

FAAS Tidža Muhi ć – Šarac

a, Sadber Kasapovića, Dejana Brkićb

aDepartment of Analytical chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

([email protected]) bDepartment of Chemical engineering, Faculty for metallurgy and materials, University of Zenica, Zenica, Bosnia and Herzegovina

Abstract: The choice of sample digestion method is of great importance. As the translation of samples in solution is the first step in the analysis,

precision and accuracy of analytical methods are dependent on it.

In this work, dry and wet digestion of different coal samples were investigated in order to determine metals (Cu, Mn, Fe, Cd, Pb, and

Zn) using FAAS. Wet digestion was carried out with mixtures of concentrated acid: HCl: HNO3 (3: 1), HCl: HNO3: HF (3: 1: 1),

HNO3: H2O2 (5: 2), HNO3: H2O2: HF (5: 2: 1). Dry digestion was carried out with and without use of fluxes : NaOH and K2S2O7. The method used to determine the concentration of metals was a method of calibration curves. The results obtained by wet digestion differ from results obtained by dry digestion. Statistical analysis of variance (Two Way Anova) and T-test at 95% confidence level showed that there was no significant difference between the efficiency of the same digestion method for different samples of coal. Keywords: heavy metals, wet digestion, dry digestion, FAAS. References

1. B. Marin, E.I.B. Chopin, B. Jupinet, D. Gauthier, Talanta,2008, 77, 282.

2. E. Margui, I. Queralt, M. Hidalgo, Trends in Analytical Chemistry, 2009, 28, 362.

3. S. Gaudino, C. Galas, M. Belli, S. Barbizzi, P. Zorzi, R. Jacimovic, Z. Jeran, A. Pati, U. Sansone,

Accreditation and Quality Assurance,2007, 12, 84. 6. INCDO – INOE2000, Research Institute for Analytical Instrumentation, Str. Donath No. 67, RO – 400293

Cluj – Napoca, Romania.

7. C. Brunori, I. Ipolyi, L. Macaluso, R. Morabito, Analytica Chimica Acta, 2004, 510,101.

8. J. Sucharova, I. Suchara, Analytica Chimica Acta, 2006, 576, 163.

9. H. Altundag, M. Tuzen, Food and Chemical Toxicology, 2011, 49, 2800. 10. A.A. Momen, G.A. Zachariadis, A.N. Anthemidis, J.A. Stratis, Microchimica Acta, 2008,160, 397.

11. M. Blander, Calculations of the Influence of Additives on Coal Combustion Deposits,

Argonne National Laboratory,2011,315.

12. K. L. Laban, B. P. Atkin, The determination of minor and trace element associations in coal using a

sequential microwave digestion procedure“, Journal of Coal Geology,1999, 41: 351-369.

13. EIA, World Energy Projections Plus, 2009. 14. Fossil fuel, http://www.worldcoal.org/coal/where-is-coal-found/, (01.08.2014.). 15. Carbon emissions, International Energy Annual 2006, (01.08.2014.). 16. J. F. Da Silva, R. J. P. Williams. The biological chemistry of the elements: theinorganic chemistry of life: Oxford

University Press, USA;2001.

285

PO-154 Synthesis of Nanostructured Metal - Containing Catalysts and Their Use at Refining of

Heavy Oil Residues V.M. Abbasov, H.J. Ibrahimov,G.S.Mukhtarova, N.Kh.Efendiyeva, R.I.Huseynova

Azerbaijan NAS Institute of Petrochemical Processes, Baku , Azerbaijan [email protected]

Abstract:

The main peculiarity of all existing technologies of hydrogenation refining of heavy oil residues is the application of the catalytic systems with applying of active elements. A structure of such catalysts imposes constraints on quality of processing raw material, in particular on content of the catalytic systems. Aluminosilcate, zeolite, carbon and other active catalytic centers applied on various porous bearers, having form of ball; sphere, tablets, cuttings, etc are on the surface and in the pores of bearers. In the conditions of thermal catalytic destruction process of heavy residues the surface and pores of bearer are covered with high-molecular (asphalt- resionous) components of raw material and consolidation products forming in the process, which is accompanied by blocking of the active catalytic centers and fast deactivation of the catalyst. It has been revealed that the nanosize particles of the catalysts of raw material hydro-conversion and also special technology of their formation in the reaction zone have not these defects.[1-3]. In this paper the basic results of the investigations of tar hydrocracking process of mixture of Baku oils in the presence of the high-disperse nanostructured suspended catalysts under low pressure for the production of the additional quantities of the light oil products and deepening of oil refining have been presented. For carrying out of tar hydrocracking the process of making of the catalytic systems by a method of impregnation of the natural minerals was carried out as follows: • Dispersed catalytic systems Ni/Kaolinite, Ni/Fe/Kaolinite have been prepared by impregnation dried at 150°C mineral of kaolinite by aqueous solutions of salts of NiCl2 (5%) and mixture of salts NiCl2, FeCl3 (5%) by their further evaporation at 150°C and thermal treatment for 4 h at 850oC in helim atmosphere on apparatus CVD (Chemical vapor deposition). • For transfer of natural mordenite (Nakhichevan deposite) to the dispersed state the samples were subjected to

the thermal treatment in helium atmosphere 850 oC for 4 h. The experiments were carried out in a rotating autoclave( of 1 l volume) at 410-460°C temperature and 0.5-2 MPa pressure. The obtained hydrogenation product after filtration from catalytic additive and deposited on it coke-like products as well as metals (Ni, V, Fe and Cu), was distilled with isolation of gasoline (start of boiling- 200°C), diesel (200-360°C) fractions and residue (>360°C). The analysis of the obtained results showed that upon hydrocracking of goudron over the tested catalytic additives the yield of the light products was significant and made 50-57% mass. The gasoline fraction produced at hydrocracking of goudron with the catalytic additive is characterized by a good colour, a low content of unsaturated hydrocarbons and octane number 70-71 points according to the research method. References 1. Gorlov E.G., Kotov A.S., Gorlova C.E. The chemistry of solid fuel, 2009, 1, p.31-39. 2. Kotov A.S., Gorlov E.G. The chemistry of solid fuel, 2009,3.,p.30-36.


286

PO-155 Ionic Liquids on the Basis of Formic Acid and Amines for Selective Purification of

Naphthalane Oil V.M.Abbasov, L.I.Aliyeva, P.A.Movsumova, A.E.Alizade

Yu.H. Mammadaliyev Institute of Petrochemical Processes of Azerbaijan National Academy of Sciences, AZ 1025, Baku, Khojaly ave., 30

e-mail: [email protected]

Abstract: National wealth of Azerbaijan – Naphthalane oil is widely used in medicine for therapy of variousdiseases.Until the end of 60-

ies of XX century Naphthalane oil is used for medical purposes as native form, however, later the investigations on improvement of its therapeutic properties by purificationhave been carried out. Naphthalane curative oil is one of the unique oils of Azerbaijan and differs in high bi-, tri- and pentacyclic naphthenes and low paraffin content. Besides, Naphthalane oil has the unique medicinal properties. However, it has been found that the main carriers of therapeutic properties of these oils are naphthenic hydrocarbons.Naphthalane oil content includes a lot of toxic compounds of aromatic hydrocarbons, resinous compounds, sulphur, nitrogen-containing substances and also microelements. Oil purification by selective solvents is more acceptable method, as it allows separating of the raw components exactly and obtaining the raffinate of required qualited out.

Taking account above-mentioned ones, we have investigated the possibility of purification of Naphthalane oil from aromatic hydrocarbons with use of ionic liquids (IL) on the basis offormic acid and various amines.ThepurificationoffractionofNaphthalaneoilwascarriedoutinaflaskwithmixingofextractantwithoilatchosentemperature, maintained on the determined level by means of thermostat. Ontheexpiryofextractiontimethe sedimentation of mixture was carried out, whereupon the lower (extract) and upper layer (raffinate) were selected. By the IR- and UV-spectroscopic methods of analysis the composition and quantitative content of aromatic hydrocarbons in raffinate were determined.

Theusedselectiveextractants-IL have been prepared on the basis of formic acid and morpholine (morpholine formate), aniline (aniline formate), pyridine (pyridine formate), di-andtriethylamine (di- and triethylamine formate).

There have been presented the results of selective purification of the fraction 260-3400C Naphthalane oil from aromatic

hydrocarbons by the use of N-methylpyrrolidon as extractants and ionic liquid obtained on the base of formic acid and morpholine (morpholinformiat) . It is possible reducing of aromatic hydrocarbons content from 18.5 to 2.0-1.5% mas. by the use of N-methylpyrrolidon and ionic liquids-morpholineformiat.

Application of this solvent at 1:3 ratio to sulphide, extraction temperature 600C and contact duration 30 min. allows reducing of total content of aromatic hydrocarbons from 18.5% mas. to 1.5 % mas. Wherein, total content of aromatic hydrocarbons and sulphide compounds is reduced sharply according to the structural-group analysis (IR-, UV- and NMR) data.

References

1. F.Kubota, M. Goto;Solvent Extraction Research and Development, 2006,13, 23-36. 2. E.Jochen, P.Wasserscheid, A. Jess;Green Chem.,2004, 7, 316-322. 3. V.M.Abbasov, L.I.Aliyeva, G.A.Najafova,B.M. Aliyev, P.A. Movsumova;The World of Oil Products,2013, 5, 35-39.

287

PO-156 Investigation of Liquid-Phase Oxidation of Naphthene-Paraffinic Hydrocarbons of

Azerbaijan Oils V.M. Abbasov, L.M. Afandiyeva, L.I. Aliyeva, L.H. Nuriyev, Ch.Q. Salmanova, S. F. Ahmadbayova, F.N.

Seyidahmadova Institute of Petrochemical Processes named after acad. Yu.H. Mamedaliyev, Azerbaijan National Academy of

Sciences, E-mail: [email protected]

Oxidative conversion of petroleum hydrocarbons in oxygenated products is one of the effective ways of rational processing of natural hydrocarbons[1]. A special place have synthetic and oxysynthetic petroleum acids (SPA и

OSPA) among the products of oxidative expansion of petroleum hydrocarbons.This work has been devoted to the aerobic oxidation of naphthene-paraffinic hydrocarbons in the presence of Mn and Cr salts of natural petroleum acids (NPA). The aim of work is to achieve higher parameters of synthesis of SPA and OSPA by special preparation of the catalysts and investigation of the mechanism of oxidation process. Liquid-phase aerobic oxidation of naphthene-paraffinic hydrocarbons at 217-330о С of diesel fraction of

Balakhany oils in the presence of the mixtures of Mn, Cr salts of natural petroleum acids (MeNPA) has been investigated. The caalytic oxidation process is realized for 7 hours at temperature 135-1400C in a barbotage reactor. Samples were taken every hour and oxidized product was separated by composition in accordance with known methods.It has been found that, after 5 hours oxidation of naphthene-paraffinic hydrocarbons the yield of obtaining synthetic petroleum acids rich 16,5%, the yield of oxysynthetic petroleum acids-18%.Despite the fact that the yield of acids mixture is high in 6th hour (~ 35%), yield of SPA is decreases, yield of OPA is increases. The yield of a mixture of SPA and OPA (~ 35%) and acid number almost remains unchanged in the 7th hour. Thus, the process is not advisable to continue for 7 hours,because it would be directed towards to produce by-products. Mechanism of oxidation process of naphthene-paraffinic hydrocarbons has been studied by IR- spectroscopy. The changes of the optical density of a carbonyl and a hydroxyl groups depending on the time were studied. Changes in the optical density of the reaction time appropriate functional groups in the samples are presented in Table.

Example D730(CH2) D1457(CH2) D1713(C=O) D941(OH) A.N of SPA,

mgKOH/g

A.N of OSPA,

mgKOH/g Raw

material 0.026 0.104 - - - -

1 0.015 0.094 0.081 0.024 100.8 98.5 2 0.015 0.092 0.102 0.030 115.8 102.6 3 0.015 0.093 0.131 0.037 120.9 118.6 4 0.015 0.093 0.142 0.039 158 130 5 0.015 0.092 0.154 0.043 159.2 131.6 6 0.015 0.093 0.099 0.028 159.8 132

It was found that the oxidation reaction should be conducted within 6 hours,as D1713(C=O) and D941(OH) after 6 hours decrease and it’s probably connected with beginning decomposition process of the acids andoxyacids. References 1.V.M. Abbasov, L.M. Afandiyeva, L.H. Nuriyev et all; Journal of Biological and Chemical Research,2014, 90-96.


288

PO-157 Investigation of Inhibitory Properties of Salts and Complexes of N- Diethylamine Amides

of Oleic Acid CO2-Corrosion

Abbasov V.M., Rzayeva N.Sh., Suleymanova S.A., Talybov A.H. Y.H. Mammadaliyev Institute of Petrochemical Processes of National Academy of Sciences of Azerbaijan,

е-mail: [email protected]

New CO2 corrosion inhibitors based on oleic acid and various amines have been synthesized and as a result amides were obtained which subsequently were sulfated and their salts and complexes have been gained. Inhibitory properties of the obtained compounds in 1% aqueous solution of NaCl, saturated CO2 at the surface of C 1018 steel have been investigated. It’s been found out that the protective effect of corrosion of the tested compounds is about 94-99.6 % at concentration of 75-100 ppm.

One of the actual problems of oil and gas industry is the protection of metallic equipments against corrosion. There are numerous methods of protection, but the most effective of them is the using of corrosion inhibitors. Recently, organic acids of vegetal origin are widely used for petrochemical synthesis. Acids derived from vegetable oils are the mixtures of saturated and unsaturated acids. In general, they contain oleic, linoleic, palmitic and stearic acids. The presence of unsaturation in the hydrocarbon radical is the prerequisite of the reactivity of these compounds and the possibility of their use in the petrochemical synthesis.

Thus, we have synthesized the amides of oleic acid on the basis of oleic and different amines. Then amides were sulfated by obtaining of their sulfate derivatives. The salts and complexes of sulfated N-dimethyl amides of oleic acid have been synthesized by the reactions listed below.

The influence of the solvents of these complexes on the kinetics of corrosion process has been studied.


289

PO-158 QQuuaalliittaattiivvee aanndd qquuaannttiittaattiivvee ddeetteerrmmiinnaattiioonn ooff ddiiffffeerreenntt ppeessttiicciiddeess in playground soils of

Sarajevo *

Aida ŠAPČANIN1,2, Mirsada Čakal2 , Mirsada SALIHOVIĆ1, Ekrem PEHLIĆ3 1Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8 - Kampus, 71000 Sarajevo, Bosnia and Herzegovina

2Faculty of Mechanical Engineering, University of Sarajevo, Vilsonovo setaliste 9, 71000 Sarajevo, Bosnia and Herzegovina 3Faculty of Biotechnical Sciences, University of Bihac, Luke Marjanovića bb, 77 000 Bihac, Bosnia and Herzegovina

Abstract: Pesticides are either imported from topsoils from outside the urban area or they are results of direct pesticide application in urban areas. In urban environments such as parks, playgrounds and gardens, polluted soils can have a direct influence on infants and children’s health, because of their inherent toxicity and widespread use. Children's exposure to pesticides is greater than adults because of their distinctive diet and play activities. Physiological immaturity also makes them particularly susceptible to the toxic effects of pesticides. Case reports and epidemiological studies indicate an association between pesticide exposure and the development of certain cancers in children including leukemia, sarcomas, and brain tumors. Even in developing countries, where labor for weed control is relatively cheap, large quantities of herbicides are used, including a wide range of chemical compounds of greatly differing structures, spectrum of toxicity to living organisms and persistence in soils. In this work the concentration of different pesticides in soils of several public playgrounds in Sarajevo (Bosnia and Herzegovina) are studied in order to investigate possible effects to children health. Soil samples from playgrounds were collected and analyzed for triazines, carbamates, dithiocarbamates,phenolic herbicides and organoclorine pesticides according to the EPA methods. Triazines, carbamates, dithiocarbamates, phenolic herbicides and organoclorine pesticides were detected in playground soils and determined concentrations in mg/kg were: <0.005, <0.05, <0.5, <0.1 and <0.001, recpectively.Playground structures made of wood are usually treated with wood-preserving pesticides. Children can absorb wood preservatives through their skin when they climb and touch the wood. They can also ingest the preservatives when they put their hands in their mouths and consume nearby contaminated dirt or sand. Consequently public children in Sarajevo playgrounds can be considered areas at high risk. Key words: playgrounds, triazines, carbamates, dithiocarbamates, phenolic herbicides and organoclorine pesticides.

290

PO-159 Demonstration in Teaching Chemistry: The Case of Two High-Schools from Sarajevo

Canton Meliha Zejnilagić-Hajrić, Ines Nuić

Faculty of Science, University of Sarajevo, Zmaja od Bosne 33-35,71000 Sarajevo, Bosnia and Herzegovina, [email protected]

Abstract: For understanding fundamental chemical principles and gaining knowledge in chemistry, observation of chemical changes during experiment are crucial. Demonstration in teaching chemistry is particularly important in primary school where students meet chemistry for the first time, but also in secondary school for more demanding and complicated experiments. This study included 60 secondary school students from two schools in Sarajevo region. We have used test of knowledge regarding demonstration experiments prescribed by Curriculum, and questionnaire for students regarding the frequency of performed experiments. Results of this study showed that teachers performed experiments prescribed by Curriculum for 1st semester of 1st grade, and those students mostly do remember what happened during experiments; results of questionnaire showed that experiments in these two schools are performed on regular basis and that students and teachers recognize the importance of demonstration in chemistry.


291

PO-160 Synthesis and Properties of Oligomers of 4-aminophenol

Rena Ahmedova, Dilbar Aliyeva, Bakhtiyar Mammadov

Ibstitute of Polymer Materials of Azerbaijan National Academy of Sciences, Sumgait, Azerbaijan, e-mail:[email protected]

Abstract: The polyfunctional aromatic polyconjugated homo- and cooligomers and also their compositions with fibres, thermoplasts, resins and elastomers are widely used in creation of sensors, transformers, smart materials and in textile industry [1,2]. In this connection, by oxidative polycondensation reaction of 4-aminophenol (AP) the polyconjugated oligomers – oligoaminophenols (OAP) have been synthesized. It has been established that the aqueous-alkaline solutions of AP intensively absorb molecular oxygen at 298-373 K, in this case the oligomer products are formed. The optimal conditions of preparation of oligomers are: temperature – 368÷373 К, [AP]0 – 0.75 mol/l,

[КОН]0 – 0.25 mol/l, reaction duration – 8 h. In these conditions the yields are reached 84%. The values of molecular weights of

oligomer products are 430890. A content of hydroxyl groups in their composition is changed in the range of 14.5÷15.3%. In the IR-spectra of oligomers it is detected the absorption band of hydroxyl groups (3200-3550 and 1230 cm-1), benzene ring (1590÷1600, 1500÷1510 and 1470÷1480 cm-1), C-H bond of aromatic nucleus (750÷770 – two neighbouring and 835÷840 cm-1– isolated). Thus, the synthesized oligomers consist of aminophenol links. OAPs are well soluble in alcohols, dioxane, dimethylformamide, acetone, etc. The obtained samples of OAP show the paramagnetic (concentration of paramagnetic centers – PMC ~7.0·1017÷9.2·1018spin/g) and semi-conducting (σ0 ~10-8÷10-4 Om-1·cm-1at 298 К, Е=1.34–1.67 eV) properties. OAPs have been used for creation of the antistatic polymer compositions on the basis of thermoplasts (LDPE, PP and PS) by introduction of 5÷15% OAP with subsequent treatment of material surface by aqueous or alcohol solution of alkali

(ρv6.4·1081.2·107Om·cm) in their composition. It has been established that an introduction of OAP in composition of rubber mixtures instead of carbon black leads to the increase of ultimate strength and decrease of specific elongation of modulus of elasticity (for ex. for rubber prepared by vulcanization of mixture on the basis of BR, including 20-25 m.p. OAP instead of carbon black, the ultimate strength is increased to 23.1-24.8 MPa, specific elongation reaches 685%, and modulus in elongation by 200% is

decreased from 9.0 to 7.9-8.6 MPa). A value of specific volume electro-conductivity of such resins is (0.2550) х 10-7Om-1·cm-1.

References

1. A. Pud, N. Ogurtsov, A. Korzhenko, Q. Shapoval,Prog. Polym. Sci.,2003, 28, 1701-1758. 2. A.Ya. Valipour, P.N. Modhaddam, B.A. Mamedov, Life Sci. J.2012, 9, 4, 409-421.

292

PO-161 New Ecologically Water-Diluting Epoxide Telomers

Almaz Chalabiyeva, Nelli Ishenko Institute of Polymer Materials of Azerbaijan National Academy of Sciences, Sumgait, Azerbaijan, e-mail: [email protected]

Abstract: The epoxide resins for today are the most perspective for preparation of paint-lacquer materials (PLM). Due to tightened international requirements for the protection of the environment there have been essential changes in the production of PLM. The traditional paint-lacquer coatingson the basis of solvents were replaced by water-diluting ones [1]. The purpose of this work – preparation of water-diluting epoxide telomers by free-radical telomerization of allyl glycidyl ether (AGE) with N-methyl and α-pyrrolidone under action of free radicals generated at thermal decomposition of ditretbutyl peroxide. Totality of the obtained data (IR-, NMR-spectroscopy, elemental analysis) allows to assume that the reaction proceeds on the following scheme:

t - BuOOBu - t 2t - BuO

O O t + BuOt - BuOH

O O

O O

N

R

Ot - BuO

t - BuOH

NR

O

NR

O

N

R

O

O

AGE

O

n

O

O

R = H (I), CH3 (II); n= 13

(I, II)

AGE

It should be noted that the reaction proceeds in one stage, the preparation process is wasteless, the unreacted AGE is again returned to the reaction. The epoxide telomers are the low-viscous resins, molecular weight is in the range of 450-480 g/mol. Epoxide number is 17-26%. Their aqueous solutions show the surface-active properties. The glossy coatings characterizing by high physical-mechanical indices and stability to aggressive media have been prepared.

References

1. N.Ya.Ishenko, A.Z.Chalabiyeva, A.M.Guliyev, J.Appl.Chem., (Russia),2011, 1713-1716.

293

PO-162 Local Catalysts: Synthesis and Application

N.Ben tahar 1 , H.Mimoun 2

1M’hamed Bougara University DZ Boumerdes – Algeria

1M’hamed Bougara University DZ Boumerdes – Algeria

[email protected] Abstract Heterogeneous catalysis has considerably influenced the refining and petrochemicals. The 30s of the 20th century have seen the development of three main types of catalysts, which are intended for primary refining processes, namely the catalytic cracking, alkylation and dehydrogenation, this is also valid for other industrial processes important is the Fischer-Tropsch process using the catalysts of Co / Fe, which converts coal into synthetic gas that is processed into cuts C5-C11-rich olefins and paraffins, this method is widely used in Japan , Germany and South Africa.

Today heterogeneous catalysis dominates and determines the development of chemical, refining and petrochemicals. They note that sales in catalysts for refineries reached $ 2.7 bilions in 2005 with an annual increase of 3.24%, still in progress.

Taken together, the industrial catalysts are the heart of the refining processes and they determine their future. Increasingly catalytic processes are developed the costs of thermal processes and the discovery of new catalysts involves the development of new processes.

Heterogeneous catalysis or contact catalysis is to achieve a transformation of liquid or gaseous reagents by using a solid catalyst, the chemical process takes place at solid-fluid interface by adsorption of reagents to the solid surface, the adsorption is in play of specific sites capable of contracting with reactive chemical bonds more or less strong. The adsorbed species formed and lead if the catalyst is selected at the desired reaction, the Sabatier principle, therefore the introduction of surface atoms or ions plays an important role. In the following work is a synthesis of catalysts using local bentonite enriched by oxides to give them a performance for the valuation of certain fractions of oil and condensate. References:

1. P. Chemical Engineering Wuithier Paris 1972 2. Michel Guisnet Ramo and Fernando Ribeiro, an Nanoworld The Zeolites Service of Catalysis,

EDP Sciences, Paris 2006 3. Technologie Oil and Gas No. 1 Moscow 2007 4. Gadi Rothenberg, Catalysis Concepts and Green Applications, Wiley-VCH Verlag GmbH & Co. in

Weinheim, Germany 2008

294

PO-163 An Efficient Synthesis, Characterization and Anti-inflammatory of Functionalized

Triazoles and Tetrazoles via 1, 3-Dipolar Cycloaddition of 2-Azido-1-(8-hydroxyquinolin-5-yl)ethanone

Shawkat Abd-Elmohsen

Chemistry Department, Faculty of Science, Assiut University, Assiut, 71516, Egypt E-Mail: [email protected]

Abstract: Abstract: A simple and efficient protocol has been developed for the synthesis of a new series of 2-(4,5-dihydro-4,5-disubstituted-1,2,3-triazol(tetrazol)-1-yl)-1-(8-hydroxyquinolin-5-yl)ethanone derivatives were synthesized via 1, 3-dipolar cycloaddition reaction of azido-1-(8-hydroxyquinolin-5-yl)ethanone (2) with some active methylene, acrylyl derivatives, substituted chalcones, and some selected schiff bases. The prepared compounds were characterized by (FT-IR, and some of them by 1HNMR, 13CNMR spectroscopy), physical properties were recorded .Some of the the prepared compounds were screened for their anti-inflammatory activity “at a dose of 10 mg/kg body weight”, which revealed promising activities relative to indomethacin used as a reference standard in this study.

NHO

OCl

NaN3DMSO

NHO

ON3

a, R= CNb, R= COOEtc, R= COOHd, R= CHO

R

THF

N

HO

O

N

NN R

N OO

Ph

CHCl3

NHO

ONN

NN

O

O

Ph

RR'

NHO

ONN

N R

R1

1

23a-d

5

4a-dBase

a, R= COCH3, R'=CH3b, R=COOH, R'=CH3c, R= COOEt, R'=NH2d, R= CN, R'=NH2

O

R

DMF

a, R= Hb, R= NO2c, R= N(CH3)2d, R= Cl

NHO

ONN N

R

Ph

O6a-d

Ar N=CHDMF

a, Ar= C6H5b, Ar = 4-Cl(C6H4)c, Ar = 4-OCH3(C6H4)d, Ar = 4-NO2(C6H4)

NHO

ONN

NN

Ar7a-d

References

1-N. S. Zefirov, N. K. Chapovskaya, V. V. Kolesnikov, Chem. Commun.1971, 1001

2- H. A. Almah, E. E. Elhassan, Int. J. Chem. Sci. 2013, 11, 85.

3- L.E. Cárdenas-Galindo, A. Islas-Jácome, C. J. Cortes-García, L. ElKaim, R. Gámez-Montaño,J. Mex. Chem. Soc.2013, 57, 283.


295

PO-164 Improvement of Operational Properties of Combustive-Lubricating Materials by Using

Esters of Vicinal Dicarboxylic Acids Maharram Ali Mammadyarova, FatmakhanymKheybarAliyevaa

aInstitute of Petrochemical Processes named Y.H.Mammadaliyev of NAS of Azerbaijan, Baku, Azerbaijan

[email protected]

Intensively developing modern technique puts very rigid requirements to lubricating oils. There is an acute issue of providing operation of equipment under extreme temperature changes. Currently produced on industrial scale synthetic oils based on esters of pentaerythritol and terminal dicarboxylic acids do not meet these requirements. Therefore the importance of the research is associated with the creation of the required oils.

In literature there are not enough data about structural correlation between chemical structure and properties of synthetic oils.Therefore, carrying out wide-ranging correlative studies has important theoretical and practical value.

At the Institute of Petrochemical Processes of National Academy of Sciences of Azerbaijan as the basis of synthetic lubricating oils have been synthesized and investigated vicinal diesters of dicarboxylic acids.

The esters of VDA are the light yellow liquid.These esters are readily soluble in organic solvents.We studied the physicochemical and viscosity-temperature properties of the synthesized esters [1] and investigate the correlation between the chemical structure and operational properties. It is revealed that esters of VDA has high rates of the low-temperature and thermal-oxidative, also lubricity properties.

Synthesized esters of VDA were tested as the bases and components of lubricating oils. For example, esters of VDA were tested as the basis of the dispersion medium to vibration-damping lubricants, synthetic oils for helicopters, instrument oils [2].

Scientific and practical interest represented the use of these essential synthetic oils as additive to the combustive-lubricating materials.

For this purpose esters of VDA of various structure was added to diesel fuels as anti-oxidizing additives and positive takes are obtained [3, 4].

On the basis of anhydrides of vicinal dicarboxylic acids was synthesized nitrogen containing derivatives which were tested as corrosion inhibitors in conservation oils andwere obtained positive results [5-7].

Reference

1. Mammadyarov M.A., Aliyeva F.Kh.; Chemistry and technology of fuels and oils, 2009, №2, p.24-27 2. Mammadyarov M.A., Aliyeva F.Kh.; Chemistry and technology of fuels and oils, 2014, №3, p.14-17 3. Patent № a 2013 0045 of Azerbaijan, 2013 4. Mammadyarov M.A., Aliyeva F.Kh.; International Porous and Powder Materials,2013, Izmir,Turkey 5. Patent № a 2013 0066 of Azerbaijan, 2013 6. Mammadyarov M.A., Abbasov V.M., Aliyeva F.Kh., Mammadova G.F.; World of oil products,

№12,2013,p.11-15 7. Mammadyarov M.A., Abbasov V.M., Aliyeva F.Kh.; ХХV the International Chemical Congress, Physical

chemistry, Turkey, Mugla, 2012, p.317


296

PO-165 Synthesis a Number of Some New Dihydrazones Compounds by Microwave Method

EbtihalQahtan Abdullah , Abdullah Saleem Khazal , AmalQahtan Abdullah Chemistry Department , College of Science , Tikrit University

Iraq Abstract:

Synthesis a number of some new dihydrazones compounds throughcondensationof thiocarbohydrozid with substituted aromatic aldehyde by microwave method .The microwave methods were unique in being very fast with high yield .Experimental values of viscosity are presented for the mixtures of dihydrazonescompounds with water over thewhole mole fraction range at 298.15 , 308.15 , 318.15 and 328.15 K .The data were used to calculate excess viscosity ,Δlnη . The results have been discussed in terms of the nature of solvent-solute interaction in the mixture . The microbial inhibitory effect of the new agents has been assessed in vitro against Gram-positive and Gram-negative bacteria activity .All dihydrazones have been characterized by IR , 1H NMR , 13C NMR spectra .

Schematic diagram Represent the reaction commonly used to prepare dihydrazone ( 1- 4).

References 1-Hasan HosseiniMonfared , OmidPourlimardan and Christophjaniak . Z . Nature Forsch . ( 2007) , 62 , 717-720 . 2-AhmetOzdemir , ZaferAsimkaplanciki, GulhanFuran-zitoubiand Gilbert Revial .Marmara Pharmaceutical Journal, 2010, 14, 79-83 . 3- SrivsatavaRitu , Pandey S . N , Singh A .K ,Anantham .International J. of Chemical research , 2010 , 2 , ISSN :0975-3699 . 4-Gursoy A , Terziglu N and Otuk . Eur . J . Med , 1997 , 32 , 753-757 . 5- RafatmMohareh , daisy H . Fleit and Ola K. Sakka . Molecules 2011 , 16 , 16-27 . 6- AhmetOzdimer , GulhanTuran-Zitouni, ZaferAsimkaplancikliandMehlikaDilekAltintop . J. Serb . Chem . Soc. 2012 , 27 (2) , 141-146 . 7-Wagnat WahbaWardkhan , NahedNaserEl.Sayed and Rafit Mil AD Mohareb . Acra Pharm , 2013 , 63 , 45-57 . 8- Volker Berl , Ivan Hue , Jean-Marie Lehn and Ande De Cian . Eur. J. Org .Chem , 1999 , 3089-3094 . 9- Sanetra J , Bogdal D , Warzala M and Boron A . Chem, Mat , 2000 , 14 , 89-95 . 10-Zaida Rodriguez , Docampo and Sijbren Otto . Chem .Commun, 2008 , 5301-5303 . 11- Regis Nguyen and Ivan Hue . Chem .Commun , 2003 , 942-943 . 12- Rameshwarpatil , Jose Portilla –Arias , Hui Ding and BinduKonda . Int .J .Mol .Sci , 2012 , 13 , 11681-11693 . 13- Max Von Delius . Edzard M . Geertsema and David A . Leihg . Org .Biomol . Chem , 2012 , 8 , 4617-4624 . 14- Peter T . Corbett , JwienLeclaire , LeurentVial , Kevin R .West and Jan-Luc Wietor . Chem. Rev, 2006 , 106 , 3653-3711 . 15- Mataliya P . Belskaya , WimDehaen and Vasiliy A . Bakulev . ARKAT , 2010 (i) , 275-332 . 16- A . John Maria Xavier , ManishaThakur and J . Margaret Marie . J. Chem.Pharma . Res , 2012 , 4(2) , 986-990 . 17- SR Jain . J . of Scientific and Industrial Research , 2003 , 62 , 293-310 .

297

PO-166 Superabsorbent eco-friendly cellulose based hydrogel as controlled-urea release packing

system Saber Ibrahim1, Maha Sultan1,* Zenat A. Nagieb2, Galal A.M. Nawwar3

1Packaging department, National Research Centre, Elbehoth Street 33, 12622, Dokki, Cairo, Egypt. 2Cellulose and Paper department, National Research Centre,Elbehoth Street 33, 12622, Dokki, Cairo, Egypt.

3Green chemistry department, National Research Centre. Elbehoth Street 33, 12622, Dokki, Cairo, Egypt. Email: [email protected]

Abstract:

To overcome the problem of economic loss belongs to agro-chemicals supplied as conventional fertilizers

which lead to serious health and environmental pollution problems.Slow release fertilizer is a promising mean

to resolve this issue by reducing the environmental hazards via packing and targeted root delivery rather.Slow

release-superabsorbent biodegradable hydrogel based on cellulose and its anionic derivative loaded with urea

as a model fertilizer. The resulting hydrogel was characterized in terms of FT-IR and SEM analysis techniques.

The effect of varying CMC/cellulose components ratios on swelling behaviors, urea loading percentage, and

slow release behavior of urea were investigated. The results revealed that, CMC/cellulose weight ratio 5:1

exhibited the maximum swelling ratio to be more than 10 times of its dry weight in both aqueous and saline

solution, the maximum percentage of urea loading achieved more than 80 % loading at 16 % urea

concentration solution. However, urea entrapment percent was 65% at the same urea concentration solution

(w/v). The urea release showed dramatically controlled and slow pattern in both water and soilas release

media. The cumulative urea release achieved 14.34 % after 12 hours based on its oven dry weight in water.

However, cumulative urea release within soil was 886.56 ppm after three weeks.

References

1. W. Wang, A. Wang.Carbohydrate Polymers2010, 91, 82.

2. J.Cai, L. Zhang. Biomacromolecules2006,7, 183-189.

298

PO-167 New Cycloalkyl-Phenol Based Antioxidant for M-8 Engine Oil

Çalışkan Mehmet Mete, Mirzayev Vagif , Bağırzade Rana , Mammadov Fahreddin , Rasulov Çıngız ANAS Institute of Petrochemical Processes named after Yu.G.Mamedaliyev


The goal of this project is to design, synthesize and evaluate para-cycloalkyl based compounds which contain hydroxyl,

carbonyl, nitrogen, phenyl, cycloaklyl groups .

Figure 1. ExperimentalDesign

We used two methods to synthesis 2-hydroksi-3-(phenylaminomethyl)-5-cycloalkyl-acetophenones:

In the first two-steps procedure , paracycloalkylphenol was reacted with formaldehyde and aniline to produce 2-hydroxy-5-

cycloalkylbenzilphenylamin .Then the product was reacted with acetic acid in the presence of zinc chloride as a catalyst to produce 2-

hydroksi-3-(phenylaminomethyl)-5-cycloalkyl-acetophenone.

In the second two-steps procedure , in the first step from the acylation reaction occurred between paracycloalkylphenol with

acetic acid in the presence of zinc chloride as a catalyst then the product by aminomethylation reaction was treated with

formaldehyde and aniline to produce similar last product.

2-hydroksi-3-(phenylaminomethyl)-5-cycloalkyl-acetophenone were tested as an antioxidant in M-8 engine oil. It was

determined that when the synthesis acetophenones 0,5% by mass of oil were added to M-8 engine oil, after 10 hours oxidation

process , it caused increase in viscosity (14.25-14.83 %) and precipitation (1.08-1.17 %). These results are acceptable for ГОСТ-

11063-77 requirements.

299

PO-168 Synthesis and Biological Evaluation of Some Benzimidazoles Derivatives

HAMMAL Lamouri, MEKSEM Saliha, and NEDJAR-KOLLI Bellara Laboratory of Applied Organic Chemistry, Houari Boumediene University of Sciences and Technology, BP 32, El-Alia, BabEzzouar Algeriers Abstract: The 2-pyrones have been used as precursors for synthesis of many heterocyclic compounds possessing potential biological activity as imidazoles, benzodiazepines, benzimidazoles and oxazinones.1-2 Considering this facts, we have focused our attention on the synthesis, of benzimidazolthione 3. The synthetic route designed for the preparation of the target compounds is summarized in scheme 1.

1

O

OH

O

OPD

EtOH

X= H, CH3, Cl

X

O

O

NH

NH2

2

C6H5N=C=S,

S=C=S

or MW3

O

O

NNH

S

X

X NH

NHO

S O

CH3

4

Figure 1. Proposed reaction mechanism of compound 3

The synthesized compounds have been evaluated for their antimicrobial and anti oxidant activity. References [1] N. Benaamane, B. Nedjar-Kolli, Y. Bentarzi, L.Hammal, A. Geronikaki, P. Eleftheriou, A. Lagunin, Bioorg & Med. Chem., 2008, 16,

3059. [2] B. Nedjar-Kolli, M. Hamdi, J. Pecher, Synthetic. Comm., 1990, 20, 1579

300

PO-169

DDeetteerrmmiinnaattiioonn of Free Amino Acids in Mushrooms ffrroomm BBoossnniiaa UUssiinngg TTLLCC and Spectophotometric Method*

Aida ŠAPČANIN1, Mirsada SALIHOVIĆ1, Amra ALISPAHIĆ1, Alema DEDIĆ1, Emina RAMIĆ1,Ekrem PEHLIĆ2

1Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8 - Kampus, 71000 Sarajevo, Bosnia and Herzegovina 2Faculty of Biotechnical Sciences, University of Bihac, Luke Marjanovića bb, 77 000 Bihac, Bosnia and Herzegovina

Abstract: Mushrooms are used because of their antitumour, antifungal and reducing hypercholesterolemia activities. They contain high protein, low fat and high dietary fibre. They are recognized as a good source of amino acids which play an important role in their flavours. The aim of this study was to determine the free amino acids in golden chanterelle (Cantharellus cibarius), peppery milk-cap (Lactifluus volemus), tawny milk-cap (Lactarius volemus), boletus (Boletus edulis), Caesar's mushroom (Amanita caesarea), common puffball (Lycoperdon perlatum) and parasol mushroom (Macrolepiota procera) from Bosnia.The simultaneous quantitative and qualitative determination was based on spectrophotometric (UV/Vis) method and thin layer chromatography (TLC) method.Sample infusion (0.1 ml) was added to 1.0 ml of 2% ninhydrin solution containing 0.8 mg/ml of SnCl2x2H2O. This solution was made up to 2.0 ml volume with distilled water. The mixtures were placed on a boiling water bath until the color was changed and then samples were quickly cooled with cold water, and adjusted to 10 ml with diluent (n-propanole:distilled water =1:1). The absorbance of these blue-purple products was measured after 10 min.TLC method was used for identification of amino acids. Thetest samples and standards were dissolved in 80% ethanol and applied to precoated TLC. Mobile phase: butanol : acetic acid : water (8:2:2 v/v/v) was used. The detection wasperformed under UV lamp at 254 nm.The highest content of free amino acids was found in boletus mushroom 0.132 mg/g and the lowest content was found in golden chanterelle 0.017 mg/g.Amino acids identified by TLC were: Lysine, glycine, alanine in boletus, Caesar's mushroom, parasol, tawny milk-cap and peppery milk-cap mushroom; tryptophan in boletus and tawny milk-cap; valin in tawny milk-cap and Caesar's mushroom; methionine in boletus, peppery milk-cap and parasol; leucine in Caesar's mushroom, peppery milk-cap and parasol; arginine in peppery milk-cap and parasol and cysteine in parasol.Mushrooms proved to be rich sources of essential amino acids in comparison with other vegetables.

Keywords: Mushrooms, free amino acids, spectrophotometric (UV/Vis) method, thin layer chromatography (TLC) method.

301

PO-170 QQuuaalliittaattiivvee aanndd qquuaannttiittaattiivvee ddeetteerrmmiinnaattiioonn ooff ddiiffffeerreenntt ppeessttiicciiddeess in playground soils of

Sarajevo *

Aida ŠAPČANIN1,2, Mirsada Čakal2 , Mirsada SALIHOVIĆ1, Ekrem PEHLIĆ3 1Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8 - Kampus, 71000 Sarajevo, Bosnia and Herzegovina

2Faculty of Mechanical Engineering, University of Sarajevo, Vilsonovo setaliste 9, 71000 Sarajevo, Bosnia and Herzegovina 3Faculty of Biotechnical Sciences, University of Bihac, Luke Marjanovića bb, 77 000 Bihac, Bosnia and Herzegovina

Abstract: Pesticides are either imported from topsoils from outside the urban area or they are results of direct pesticide application in urban areas. In urban environments such as parks, playgrounds and gardens, polluted soils can have a direct influence on infants and children’s health, because of their inherent toxicity and widespread use. Children's exposure to pesticides is greater than adults because of their distinctive diet and play activities. Physiological immaturity also makes them particularly susceptible to the toxic effects of pesticides. Case reports and epidemiological studies indicate an association between pesticide exposure and the development of certain cancers in children including leukemia, sarcomas, and brain tumors. Even in developing countries, where labor for weed control is relatively cheap, large quantities of herbicides are used, including a wide range of chemical compounds of greatly differing structures, spectrum of toxicity to living organisms and persistence in soils. In this work the concentration of different pesticides in soils of several public playgrounds in Sarajevo (Bosnia and Herzegovina) are studied in order to investigate possible effects to children health. Soil samples from playgrounds were collected and analyzed for triazines, carbamates, dithiocarbamates,phenolic herbicides and organoclorine pesticides according to the EPA methods. Triazines, carbamates, dithiocarbamates, phenolic herbicides and organoclorine pesticides were detected in playground soils and determined concentrations in mg/kg were: <0.005, <0.05, <0.5, <0.1 and <0.001, recpectively.Playground structures made of wood are usually treated with wood-preserving pesticides. Children can absorb wood preservatives through their skin when they climb and touch the wood. They can also ingest the preservatives when they put their hands in their mouths and consume nearby contaminated dirt or sand. Consequently public children in Sarajevo playgrounds can be considered areas at high risk. Key words: playgrounds, triazines, carbamates, dithiocarbamates, phenolic herbicides and organoclorine pesticides.

302

PO-171 Comparison Study between Crude Alkaloid Extracts fromBaobab(Adansonia Digitata)

Leaves and Some Anti-Malaria and Antibiotics Drugs in Nigeria, Using Infrared Spectroscopy

Abiona, Dupe Lydia,a Olaoyeb, Fatimo Olubukola, and Bakare, Adetutuc. a,b,cDepartment of Chemistry, The Polytechnic, Ibadan, Oyo State, Nigeria.

ABSTRACT Adansonia digitata(Baobab) leaves, are locally known as Kuka in Nigeria, and are used to make Kuka soup. Baobab leaves are used in folk medicine as a diaphoretic, an astringent, an expectorant and as a prophylactic against fever. The leaves also have hypo-sensitive and antihistamine properties. The leaves are used to treat kidney and bladder diseases, asthma, general fatigue, diarrhoea, inflammations, insect bites and guinea worm. Baobab roots and leaves are been investigated in an attempt to identify the potential bioactive compounds associated with these parts of the plant. This study compared screened alkaloids from C. digitata plant leaves with some antimalaria and antibiotic drugs.Alkaloids were extracted from water, methanol and ethanol crude extracts of baobab leaves using dichloromethane, and were characterized using infrared spectroscopy. The infrared spectrophotometricanalysis of the anti-malaria drugs specifically, chloroquine, alaxin,artesunate; and the antibiotics: flagyl, tetracycline, and septrin were carried out, and were compared with those of the alkaloids isolated from baobab leaves’ water, methanol and ethanol extracts . They were found to contain similar bands of absorption, which suggests that they contain similar active ingredients. References

Masola, SN., Mosha, R.D., Wambura, P.N. (2009). Assessment of antimicrobial activity of crude extracts of stem and root barks from Adansonia digitata (Bombacaceae) (African baobab). African Journal of Biotechnology. 8: 5076-5083.

Vertuani S, Braccioli E, Buzzoni V, Manfredini S (2002). Antioxidant capacity of Adansonia digitata fruit pulp and leaves. Acta Phytotherapeutica, 86: 2-7.

Wickens, G.E.( 1979). The uses of the baobab (Adansonia digitata L.) in Africa. In: Taxonomic aspects of African economic botany, editor, Kunkel, G. Chapter 15.

Atawodi, S.E.(2005).Review-Antioxidant potential of African medicinal.African Journal of Biotechnology, Vol. 4 (2), pp. 128-133.

303

PO-172 Benzylidens: Synthesis and Reactivity

KhaledMESBAHa, SalahRHOUATIa, Yulian. M VOLOVENKOb and Zoya VOITENKOb

alaboratoire des produits naturels d’origine végétale et de synthèse organique Université Frères Mentouri

Constantine. Algerie

bChemical Departement Kiev Taras Schevchenko University. Ukraine [email protected]

Abstract The benzylidens compounds resulted from the condensation between the heterocyclic aldehydes and the molecules with activated methylene. Because of the double band, they can react with the nucleophilic ones or electrophilic ones, or to carry out reaction of cycloaddition. These reactivities made the benzylidens very known for the synthesis of the poly-heterocyclic compounds which can be presented a large potential opposite the biological activity.

References

1. Jurong Yu, Jeffrey De Pue and David Kronenthal. Tetrahedron letters. 2004, 45, 7247-7250 2. Dorota G. Piotrowska. Tetrahedron2006, 62, 12306-12317

304

PO-173 Synthesis of MacrocyclicPolyether’sBased on Alicyclic Dioximes

Budagova R.N.,Zeynalov S.B., Abdullayeva N.A. The Institute of Catalysis and Inorganic Chemistry named after aсad. M.NagiyevofAzerbaijan National

Academy of Sciences, Az1 143, H.Javidave.,113, [email protected]

Abstract Macrocyclicpoliethers have extraordinary chemical features that include ability to form coordinative compounds with metal cautions in crystalline form and in solution. Macrocyclic compounds are characterized by high resistance and catalytic activity and are extractant of different metals. They are successfully applied in analytic chemistry, thin organic chemistry, phase transfer catalysis, ecology, medicine, electrochemistry, metallurgy and agronomy.There is no information about synthesis of crown ethers on the basis of cyclic dioximes in literature. Recently we have synthesized nitrogen-containing crown ethers based on aliphatic and alicyclic dioximes. [1-2] Continuing the research in this direction we developed the metod of obtaining new crown ethers by polycondensation reaction of 4-isopropyl-1,2-cyclohexanedione dioximes(4-isopropyl-nyoxime) with ethylene oxide or choloroethanol in the presence of alkali. The reaction is held in benzene sphere at 25-30℃ and at a constant addition of an excess of ethylene oxide or choloroethanol. The length of the reaction is 10-12 hours with the chart stated below:

C=NOH

C=NOH

CH

CH3

CH3

CH2 CH2

O

Cl CH2 CH2OH

C=N-O-(CH2-CH2-O)n-CH2-CH2

C=N-O-(CH2-CH2-O)n-CH2-CH2

CH

CH3

CH3

O+

n

NaOH

where n=4÷16 The polycondensation reaction is held until the end allocation of water that is collected in a trap of Din Stark through an azeotrope mixture of benzene – water. The solvent is removed on a rotary evaporator and the rest is acidified with 5 ml of concentrated HCl( until the acid reaction by universal indicator ), it is washed, filtered and then it is washed with acetone and dried in an oven.Developed method of preparation of crown ethers helps to avoid side reactions of oligomerization and isomerization of the starting compounds and to achieve quantitative yield of target products of 58–78%.The structure of crown-ethers is proved by NMR 1N, IC and mass – spectroscopy. IC spectrum: the presence of stripes in the field of 1135-1138 sm-1 is characteristic of crown ether’s fragment, for the polyether chains 1440-1500 sm-1 , 1450,1350 (Vch), 1120 (Vco) sm-1.NMR spectrum 1H, 𝜎.m.d: ~8,2 – 7,3 m.d., 3,56 (s), 4,42 (s), 7,32 (m) m.d., proton signals of crown ethersappear as multiplets in the field of – 4,2 – 2,6 m.d.Preliminary tests of the synthesized nitrogencontainingmacrocyclic compounds showed the expressed ability of the latter to complexformation and highly selective attenuation while extraction of metals in various fields. References

1. R.N.Budagova,S.B.Zeynalov,N.A.Gasimova, XXV, InternationalChugaevsk conference on coordinative chemistry, Suzdal, 180-181 (2011)

2. R.N.Budagova,S.B.Zeynalov, XIX Mendeleev congress on general and applied chemistry, Volgograd, 484(2011)


305

PO-174 Features of Phase Formastionin the Tl5Te3(Tl2Te)-Tl9LnTe6-Tl9BVTe6 Systems

SamiraIMAMALIYEVAa, TuranGASANLYb, FuadSADYGOVb,

MahammadBABANLYa,b

aInstitute of Catalysis and Inorganic Chemistry of NAS Azerbaijan, Baku, Azerbaijan, [email protected]

bDepartment of General and Inorganic Chemistry, Baku State University, Baku, Azerbaijan

Heavy metal chalcogenides have attracted an increasinglevel of attention because of their promising

thermoelectricproperties. Thallium subtelluride Tl5Te3, possess thermoelectric characteristics owing to features of the crystal

structure has a lot of ternary analogs. One of them, Tl9BiTe6 shows high ZT value comparable to the state-of-the-art thermoelectric materials (ZTmax = 1.2 at 500 K)

Thallium lanthanide tellurides, Tl9LnTe6, might exhibit good thermoelectric properties like Tl9BiTe6 as they are also isostructural to Tl5Te3.Moreover, lanthanide elements are lighter than thallium or bismuth elements resulting in significant mass fluctuation between the Tl and Ln atoms, which may further lower the thermal conductivity and to improve the thermoelectric properties.

In our previous studies [1,2], we reported the new ternary compounds Tl9LnTe6(Ln-Ce, Nd, Sm, Gd) also crystallizing in Tl5Te3-type crystal structure. Phase equilibriain the Tl5Te3 (Tl2Te)-Tl9NdTe6-Tl9BiTe6 systems were investigated in order to obtain solid solutions with Tl5Te3 structure[3].

Later, a series of tellurides Tl10-xLaxTe6 (0.2x1.15) was synthesized, structurally characterizedand the thermoelectric properties determined [4,5].

In the present study, the original results of the physico-chemical study of Tl5Te3 (Tl2Te)-Tl9LnTe6-Tl9BVTe6(Ln- Sm, Gd; BV-Sb, Bi) systems are presented and discussed together with the previously studied analogous systems.

In particular, it is shown that all Tl5Te3-Tl9LnTe6-Tl9BVTe6systems are isomorphic, i.e. characterized by formation of continuous fields of solid solutions with Tl5Te3-type structure (δ-phase).

The Tl2Te-Tl9LnTe6-Tl9BVTe6systems form the wide areas of δ -solid solutions. There are a narrow areas of α-solid solutions based on Tl2Te and two-phasic areasα+δ.

Furthermore, the crystal structure and some physical properties of intermediate phases are discussed.It was shown that obtained intermediate phases possess thermoelectric and magnetic properties.

*The study is supported by the Science Foundation of the State Oil Company of Azerbaijan Republic (Grant for the project "Preparation and investigation of new functional materials based on complex metal chalcogenides for alternative energy sources and electronic engineering", 2014).

References

1. S.Z.Imamaliyeva, F.M.Sadygov, M.B.Babanly;Inorg.Mater.2013, 44 935 2. M.B.Babanly, S.Z.Imamaliyeva, D.M.Babanly, F.M.Sadygov; Azerb. Khim. J., 2009, 2, 122-125. 3. Babanly M.B., Tedenac J-C., Imamalieva S.Z., Guseynov F.N., Dashdieva G.B;J.Alloys Compd., 2010,

491,230 4. S.Bangarigadu-Sanasy, C.R.Sankar, A.Assoud, H.Kleinke; Dalton Trans.2011, 40 862 5. S.Bangarigadu-Sanasy, C.RSankar., P.Schlender, H.Kleinke;J.Alloys Compd.2013, 549, 126


306

PO-175 Anti tumoral Activity of Hydrazylpyrrolidine 2, 5 dione and 2-Thioxo Imidazolidine 4-one

S. AichoucheBouzroura1, L. Salhi1, Boudjlida2, S. BouguerraAouichat2, B. NedjarKolli1

1 Laboratory of Applied Organic Chemistry, HouariBoumediene University of Sciences and Technology, BP 31, El-Alia, Bab-Ezzouar, 16111, Algiers, Algeria

2Laboratory of Cellular and Molecular physiopathogyFaculty of biological Science, HouariBoumediene, University of Sciences and Technology, BP 31, El-Alia, Bab-Ezzouar 16111, Algiers, Algeria

Abstract

In the past decades, great efforts have been devoted to introducing thiohydantoins and their derivatives into desirable substrates, such as pharmacophore. Compounds containing the thiohydantoin structural motif have been identified to display a wide range of biological activities. For example, many of them exhibit anticonvulsant, antimicrobial and potential antitumor activities. In this context, we have investigated in vitropotentialanti tumoralactivitiy ofhydrazylpyrrolidine 2, 5 dione1 and 2-thioxo imidazolidine 4-one 2 previously synthesized by us1

Compounds 1 and 2were evaluated at 370 µg/mLon proliferation (Human Laryngeal Carcinomacells) HEp2 cells, the malondialdehyde (MDA) were measured after cell treatment as indicator of lipid peroxidation.

NO O

H

NH NH

COOEt

N

N

O S

C6H5

NH

O

NH2

O

H3CHN

1 2

S. Bouzroura, L. Hammal, B. Nedjar-Kolli, F. Balegroune, M. Hamadène, S. Poulain, Synthetic Communications, 2008, 38, 448-455. S. AichoucheBouzroura, L. Salhi, A. Belkebir, O. Ait-Yahia, A. Boudjlida, S. Aouichat, B. N. Kolli. International Journal of pharmaceutical, Chemical and Biological Sciences (IJPCBS)2014, 4 (3), 447-452

307

PO-176 New Approach Synthetic of 4-ThiazolidinonesScaffold. Evaluation of Antimicrobial

Activity Rosa Nechak,aSamia A. Bouzroura,aBellara N. Kolli, aYaminaBenmalek,bLydia Salhi,a Sophie P.

Martini,cVincent Morizur,cElisabetDunachc aLaboratory of Applied Organic Chemistry, HouariBoumediene University of Sciences and Technology, BP 31,

El-Alia, Bab-Ezzouar, 16111, Algiers, Algeria

bLaboratory of microbiology, HouariBoumediene, University of Sciences and Technology, BP 31, El-Alia, Bab-Ezzouar 16111, Algiers, Algeria

cInstitut de Chimie de Nice UMR 7272, Université de Nice-Sophia Antipolis, CNRS, Parc Valrose, 06108 Nice Cedex 2, France.

Abstract

In recent years, 4-thiazolidinones and their derivatives have become among the most extensively investigated compounds. They constitute an important group of heterocyclic compounds, displaying a broad spectrum of biological activity. 1-2The diversity in the biological response of these molecules has attracted extensive interest of both medicinal and chemists. In this work, we report a new approach synthetic to the formation of 4-thiazolidinone compounds 3a-h in moderate yield,3 from reaction of the thiosemicarbazones 1a or 1c and maleimide derivatives 2a-d described in Scheme 1.

1a or 1c

OCH3

OH

O

NN

CH3

S

NR

O

NH

R'O

HxHa

Hb

3a-hR' = H, CH3, C2H5, C6H5 3a-d, R= C2H5, R' = H, CH3, C2H5, C6H5

3e-h, R= H, R' = H, CH3, C2H5, C6H5

OCH3

OH

O

NNH

CH3

NHR

S +N OO

R'

2a-d

CH3CN, H2SO4

Reflux

Scheme 1.Synthetic pathway to generate 4-thiazolidinone structures 3a-h.

The 4-thiazolidinones 3a-hwere synthesized and tested for their in vitro antimicrobial properties against Gram positive, Gram negative and antifungal bacteria. References

1. Shuobing, W.; Yanfang, Z.; Guogang, Z.; Yingxiang, L.; Ning, Z.; Ping, G. Eur. J. Med. Chem. 2011, 46, 3509–3518. 2. Ramya, V. S.; kallapa, M. H.; Rangappa, S. K.; Mallinath, H. H. Eur. J. Med. Chem. 2010, 45, 1753–1759. 3. N e c h a k . R ; B o u z r o u r a . S ; B e n m a l e k . Y ; S a l h i . L ; M a r t i n i . P . S ; M o r i z u r . V ; 4. Dunach. E;Kolli. B.N. Synth Comm. 2015, 55, 262-272.

308

PO-177 Thionation of β-Enaminones with Lawesson's Reagent: Synthesis of

Pyranopyrazole Derivatives Houria LAKHDARIa,b, Norah BENNAMANEa, Brahim CHERFAOUIa, Bellara NEDJAR-KOLLIa

aLaboratory of Applied Organic Chemistry, Houari Boumediene University of sciences and Technology, BP 32, El‐Alia, Bab‐Ezzouar, 16111, Algiers, Algeria.

bResearch Center of Technical and Scientific Research in Physical and Chemical Analysis (CRAPC), BP 248 Algiers RP 16004, Algeria. E‐mail: [email protected]

Abstract: β-enaminones are convenient and useful precursors in pharmaceutical development and in heterocyclic synthesis.1 In previous studies, our research group reported the synthesis of series of benzotriazoles, 1,5-benzodiazepines and pyrazoloxazine derivatives based on the use of enaminones resulting from dimedone and 2-pyrone.2,3 In continuation on these studies, we investigate in this work the behavior of pyrazoloenaminones 1 towards Lawesson’s reagent (2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide, LR) (scheme 1).The reaction resulted in the formation of 3,6-dimethyl-1-phenylpyrano[2,3-c] pyrazole-4(1H)-one 2 and its thione analog 3 whichareheterocyclic scaffolds with promising biological activity. The structures of the synthesized compounds were elucidated by spectroscopic methods, including 1H-NMR, 13C-NMR and mass spectrometry.

CH3

NHR O

N

NOH

Ph

CH3

LR

OCH3

N

N

X CH3

Ph

2: X= O ; 3: X= S1

Scheme1.Synthetic pathway to pyranopyrazoles derivatives 2 and 3

References

1. Stanovnik, B.; Svete, J. Chem. Rev.,2004, 104, 2433. 2. N. Bennamane, R. Kaoua, L. Hammal, B. Nedjar-Kolli, Org. Commun., 2008,1:3,62. 3. a) N. Benaamane, B. Nedjar-Kolli, Y. Bentarzi, L. Hammal, A. Geronikaki, P. Eleftheriou, A. Lagunin, Bioorg. Med. Chem.,2008, 16, 6, 3059. b) N. Bennamane, B. Nedjar-Kolli, Athina A. Geronikaki, P. Th. Eleftheriou, R. Kaoua, K. Boubekeur, P. Hoffman, S. S. Chaudhary, A. K. Saxenaf, ARKIVOC (ii), 2011, 69.


http://www.ncbi.nlm.nih.gov/pubmed?term=Benaamane%20N%5BAuthor%5D&cauthor=true&cauthor_uid=18191402

http://www.ncbi.nlm.nih.gov/pubmed?term=Nedjar-Kolli%20B%5BAuthor%5D&cauthor=true&cauthor_uid=18191402

http://www.ncbi.nlm.nih.gov/pubmed?term=Bentarzi%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=18191402

http://www.ncbi.nlm.nih.gov/pubmed?term=Hammal%20L%5BAuthor%5D&cauthor=true&cauthor_uid=18191402

http://www.ncbi.nlm.nih.gov/pubmed?term=Geronikaki%20A%5BAuthor%5D&cauthor=true&cauthor_uid=18191402

http://www.ncbi.nlm.nih.gov/pubmed?term=Eleftheriou%20P%5BAuthor%5D&cauthor=true&cauthor_uid=18191402

http://www.ncbi.nlm.nih.gov/pubmed?term=Lagunin%20A%5BAuthor%5D&cauthor=true&cauthor_uid=18191402

http://www.ncbi.nlm.nih.gov/pubmed/18191402

309

PO-178 Synthesis and Biological Evaluation of New imidazo[1,2-a]pyridine Derivatives

Saléha BAKHTAa, Larbi Arslane HAOUCHINE a, Bellara NEDJAR-KOLLIa aLaboratory of Applied Organic Chemistry, Houari Boumediene University of sciences and Technology, BP 32, El‐Alia, Bab‐Ezzouar,

16111, Algiers, Algeria. E‐mail:[email protected]

Abstract: The emergence of multiple drug resistant Gram-positive and Gram-negative bacteria and the significant increasing of dermal fungal infections in the last years prompt us to search for new antibacterial and antifungal agents with better activity profile.1 Imidazo[1,2-a]pyridines, pyranic systems and fused pyrans have been shown to possess diverse biological proprieties including antibacterial2 and antifungal.3 In this context, wehavesuccessfully synthesized in water, 4-imidazopyridinylbenzochromene-2-carbonitrile 2 and 4-imidazopyridinyloxopyranopyran-2-carbonitrile 3by reacting the precursor 2-(imidazo[1, 2-a]pyridinylmethylene)malononitrile 1with 1-naphtol and 4-hydroxy-2-pyronerespectively, in presence of catalytic quantity of tetra-n-butyl ammonium bromide (TBAB) (Scheme 1). Structures of these new compoundswere assigned on thebasis of IR, 1H and13C NMR spectral data. These compounds were evaluated for theirin vitro antimicrobialscreening on different strains of bacteria and fungi: Escherichia coli, Staphylococcus aureus, baccillus subtilis,aspergillus brasiliensis, and candida albicans Both the synthesized molecules showed moderate antimicrobial activity.

O

NH2

N

N

N

O

O

NH2

N

N

CH3

O N

N

N

N

N

1 2 3 Scheme1

References

1. E.M. Johnson, D.W. Warnock, J. Luker, S.R. Porter, J. Antimicrob. Chemother., 1995, 35, 103. 2.a) S. T. Nguyen , J. D. Williams, M. M. Butler , X. Ding , D. M. Mills, T. F. Tashjian, R. G. Panchal, S. K. Weir, C. Moon, H. Ok, K. Jeremiah, A. Marsden, N. P. Peet, T. L. Bowlin, Bioorg. Med. Chem. Lett., 2014, 24, 3366. b) J. C. Teulade, G. Grassy, J.P. Girard, J.P. Chapat, M. M. S. Buochberg., Eur. J. Med. Chem., 1978, 13, 271. 3.a) O. zdemir, G. Turan-Zitouni, Z. A. Kaplanc|kli, G. Is¸can, S. Khan and F. Demirci, Eur. J. Med. Chem., 2010, 45, 2080., b) A.H.M. Hussein, M.A.M. Gad-Elkareem, A.A.M. El-Adasy, A.A. Khames, I.M.M. Othman, Inter. J. Org. Chem., 2012, 2, 341.


310

PO-179 New Synthesis and Reactivity of 3-Acetoacetyl-2H-chromen-2-one, Based Condensed

Heterocycles Soumaya Ben Mohameda, Yahia Rachedia,* , Maamar Hamdia, Françoise Dumas,b

a: Laboratory of Applied Organic Chemistry, Faculty of Chemistry, University of Science and Technology Houari Boumediene BP 32, El-Alia, 16111, Bab-Ezzouar, Algiers, Algeria.

b: CNRS-Université Paris Sud, UMR 8076 Bio CIS, Laboratoire de Pharmacognosie, IPSIT and LabEx LERMIT, Faculté de Pharmacie, 5, rue Jean-Baptiste Clément, 92296 Chatenay-Malabry Cedex, France.

E-mail : [email protected] Abstract Up to the present time a whole series of preparations based on chromen-2-one possessing a wide spectrum of biological action, coumarins derivatives form an exceptional class of oxygen containing heterocyclic compounds, are useful intermediates for synthesis of various compounds, playing a key role in the medicinal area due to their structural diversity and pharmaceutical properties. Their use as antioxidants and antimicrobial, antiviral, and antitumor preparations is known, while some derivatives are used as fluorescent chemosensors. [1-

3] A simple, efficient and ecofriendly procedure has been used for the synthesis of 3-acetoacetylcoumarins from 2,3,4-trihydroxybenzaldehyde and 4 hydroxy-6-methyl-2H-pyran-2-one using piperidine as a catalyst in ethanol medium under microwave condition. The obtained product was used as starting material for synthesis of other new molecules The structure of synthesized compound has been established on the basis of spectral analysis including IR, 1H and 13C NMR, and mass spectroscopic analysis data. Keywords: pyran,coumarin, multi-component reaction, synthesis. References [1] Manas, M. M.; Pleixats, R. Dehydroacetic Acid, Triacetic Acid Lactone and Related Pyrones. Advances in Heterocyclic Chem., 1992, 53, 1-84. [2] Egan D, O’Kennedy E, Moran E, Cox D, Prosser E, Thornes RD. Drug Metab Rev, 1990, 22, 503–529. [3] Makhloufi-Chebli, M.; Hamdi, S. M.; Hamdi, M.; Rabahi, A.; Silva, A. M. S. J. Mol. Liq., 2013, 181, 89–96.


311

PO-180 Synthesis and Antibacterial Activity of Some New Bis-1,3,4-Thiadiazole Derivatives

Derived from Adipic Acid

Mustafa Yawuz Jamal ChemistryDepartment, College of Education for pure Science, Diyala University, IRAQ

Abstract: The present work consists of three parts, the first part deal with the synthesis of some new bis -1,3,4-thiadiazole involve six steps as show in scheme. The second part (characterizatization): The synthesized compounds have been characterized on the basis of spectral analysis FT-IR ,1H-NMR spectroscopy ,there melting point and the results are compatible with their assigned structures . The part three: Antibacterial Activity, some of the synthesized compounds were screened for antibacterial activity againstStaphylococcus aureus, Escherichia coli, Salmonella typhiandPseudo aerugenosa Figure 1. Reagents and conditions: (1) ethanol absolute, H2SO4 con. , reflux (3h); (2) hydrazine hydrate, EtOH, reflux (1h); (3) KOHand CS2, EtOH, stirring(24h); (4) conc.H2SO4,stirring(1.5h); (5) appropriate acid chloride,pyridine,stirring(4h); (6) appropriate alkyl halide, KOH, reflux(2h).

References

1. Sheinker Y. N., Postorski I. Y.,and Voronina. M. N., Chem. Abs., 54: 4147 (1960).

2. Matysiak J., Malinski Z. (2007) ,Russ J Bioorg Chem;33:594–601.

3. Bhat A.R., Tazeem, Azam A., Choi I., Athar F. Eur J Med Chem.,2011.46:3158–3166.

4. Verma S., Srivastava S.K., Samadhiya P.,2011. Int J Pharm Res Dev;11:73–81. 5. Vasoya S.L. , Paghdar D.J., Choratia P.T. ,and Joshi H.S.; journal of sciences 2005,16(1): 33-36 .

HO2C(CH2)4CO2H EtOC(CH2)4COEt

OO OO OS

H2NHNC(CH2)4CNHNH2

O

OO

S

K S-CHNHNC(CH2)4CNHNHC-S K

NN

S(CH2)4

NN

SSHHS

NN

S(CH2)4

NN

SSCRRCS

NN

S(CH2)4

NN

SSRRS

1a 2a 3a4a

5a

(1) (2) (3)

(4)

(5) (6)

6 7

312

PO-181 Crystallization and Phase Transition of Solid Solutions Based on the AI

8BIVX6 (AI-Cu, Ag; BIV-Ge, Sn; X-S, Se) Compounds

1YusifYusibov, 1Isfendiyar ALVERDIYEV, 1VusalaABBASOVA, 2Leyla MASHADIYEVA, 2Dilgam TAGIYEV, 2Mahammad BABANLY

1Ganja State University, Ganja, Azerbaijan

2Institute of Catalysis and Inorganic Chemistry, Azerbaijan National Academy of Sciences, Baku, Azerbaijan

[email protected]

Complex copper and silver chalcogenides with germanium subgroup elements are promising materials for optoelectronics and thermoelectrics thanks to their excellent semiconductor properties. A number of these compounds exhibit superionic conductivity and are used as ion-selective electrodes, solid-state electrolytes in the different kind of electric batteries, sensors, displays, etc. [2]. Recently, single crystalline submicropyramids of the orthorhombic Ag8SnS6 have been proposed as a new member of superior photocatalytic materials [3].

In order to develop modern preparativemethods and controlled synthesis of this kind of novel complexmaterials it is necessary to investigate phase relationships and toplot phase diagrams of the respective systems. In particular, binaryand more complex systems composed by isostructural compoundsare very interesting for fabricating solid solutions in the wide concentration range

All ternary compounds of AI8BIVX6type have phase transition. Their high-temperature modifications are isostructural and

crystallize in cubic (F-43m)system, however low-temperature ones crystallize in orthorombic or hexagonal system. This allows us to expect the formation of wide series of solid solutions in AI

8GeX6-AI8SnX6 (I), AI

8BIVS6-AI8BIVSe6 (II)Cu8BIVX6-Ag8BIVX6 (III) systems.

This work is devoted to investigation of phase relations in the (I)-(III) systems and some properties of solid solutions. Starting compounds and samples were synthesized from high-purity elements in sealed silica ampoules under vacuum (10-

2Pa)followed by homogenizing annealing at 900 K for about 500 h. DTA, XRD and SEM measurements were employed to analyze the samples. The XRD data were collected using a Bruker D8

ADVANCE diffractometer (Cu-K radiation). DTA of the equilibrated alloys was carried out using a NETZSCH 404 F1 Pegasus system. The microstructure and equilibrium compositions of the phases were determined by FEI Quanta™ 250 scanning electron microscope with Oxford Instruments energy dispersive X-ray spectrometer (SEM–EDS).

Based on experimental data the T-x diagrams and concentration dependences of crystal lattice parameters are plotted.It was shown that all systems are characterized by continuous series of solid solutions between high temperature modifications of starting compounds. In systems (I) a continuous series of solid solutions also formed between the low-temperature orthorhombic modifications of the initial compounds. A wide range of solid solutions based on low-temperature modifications of the ternary compounds are form in system (II) and (III).Formation of solid solutions in these systems decreases the temperature of polymorphic transitions of compounds down to room and low.

References 1. M.B.Babanly, Y.A.Yusibov, V.T.Abishev; Ternary Chalcogenides Based onCopper and Silver, BSU Publ., 1993. 2. W.Q. Hu, Y.F. Shi, L.M. Wu; Cryst. Growth Des. 2012, 12, 3458–3464.


313

PO-182 Phase Equilibria in the SystemsTl-X-I (X-S, Se,Te) andThermodynamic Properties of

Thallium Chalcogenide Iodides

Dunya BABANLY, Akif ALIYEV, Dilgam TAGIYEV

Institute of Catalysis and Inorganic Chemistry, Azerbaijan National Academy of Sciences, Baku, Azerbaijan

[email protected]

The synthesis and characterization of new functional materials with tailored properties are a topical area for materials research. Complex chalcogenides and chalcogenidehalides of heavy p metals are considered perspective functional materials that exhibit semiconductor, thermoelectric, photoelectric, and magnetic properties.

The phase equilibria and thermodynamic properties of the Tl-S(Se,Te)-I systems at the Tl-TlI-X (S,Se,Te) compositional range were investigated in our previous works [1-3].

In this contribution we present the results of complex research of the phase equilibria and thermodynamic properties in the systems Tl-S(Se,Te)-I obtained using methods DTA, SEM, X-ray analyses, as well as measurement of EMF of the concentration chains (-) Tl (s) / glycerin, Tl+ / (Tl-X-I) (s) (+) (1).

The solution of KI in glycerin with addition of ~0,5 mass.% TlI used as electrolyte in chains (1). The equilibrium alloys of different composition from area of concentration Tl2X-TlI-X were used as the right electrodes. Measurements of EMF carried out by compensative method in the 300-430 K temperature range.

Alloys were prepared from preliminary synthesized and identified iodides and chalcogenides of thallium and elementary components of a high purity by melting in evacuated (~10-2 Pa) quartz ampoules with the subsequently homogenized annealing at 20-30K below the solidus temperatures for 500-1000 h.

The complete T-x-y diagrams of the systems Tl-X-I, their some polythermal sections and isothermal section at 300 K are constructed on the base of the received experimental data. The area of primary crystallization, types and coordinates of non- and monovariantequilibria are determined.

Experimental results show that these systems are characterized by formation of the ternary compounds Tl6SI4, Tl6SeI4,Tl5Se2I, Tl5Te2I and Tl2TeI6. The compoundsTl5Se2I and Tl5Te2I are non-stoichiometric phases with a wide homogeneity rangealmost completely covering the Tl2-xSe-Tl5Se2I (0≤х≤0,3) and Tl2Te-Tl5Te3-Tl5Te2I compositional intervals. The homogeneity areas of other compounds are less than 1%.The presence of wide solid solution areas on base of Tl5Se2I and Tl5Te2I is connected to the structural features of these compounds:Tl5Se2I and Tl5Te2I crystallize in tetragonal structure of typeTl5Te3 (Sp.gr. I4/mcm). Their crystal lattices parameters are close to those for Tl5Te3.

The relative partial molar functions of thallium in alloys are calculated from the EMF results.The standard integral thermodynamic functions of the ternary compounds and solid solutions on their base were calculated by integration of the Gibbs-Duhem equation.

*This work was supported by Science Development Foundation under the President of the Republic of Azerbaijan – Grant № EIF/GAM-2-2013-2(8)-25/12/4

References 1. D.M.Babanly, G.M. Guseinov, M.B.Babanly, F.M.Sadygov;Russ. J. Inorg. Chem. 2012,57, 90-99. 2. D.M.Babanly, I.R.Amiraslanov, A.V.Shevelkov, D.B.Tagiyev; J. Alloys Compd.2015(in print) 3. D.M.Babanly, I.M.Babanly, S.Z.Imamaliyeva, V.A.GasimovA.V.Shevelkov;J. AlloysCompd, 2014, 590, 68-

74


314

PO-183 Contribution of theChromatographic Step intheUncertainty ofan HPLC Analytical

Procedure

O Djellouli a, b, E Rozetc, H Bensaoulab, B Dahmanib, P Hubertc

a University Centre of Naama, BP 66, 45000 Algeria b Laboratory of Spectrochemistry and Pharmacology Structural, University of Tlemcen, BP. 119, 13000

Tlemcen, Algeria c Laboratory of Analytical Chemistry, CIRM, Institute of Pharmacy, University of Liège, CHU, B36, Tour 4,

Avenue de l’Hôpital 1, B-4000 Liège, Belgium E-mail: [email protected]

The main chromatographic factors that affect the precision of the HPLC response (peak area) are the detection, the flowrate, the mobile phase composition, the column temperature,the baseline drift and the baseline noise. While the instrument response is the ultimate result of HPLC analytical procedure, its corresponding variability (assessed from the validation data), outlines the influence of all sources of uncertainties relating to the entire earlier steps of the procedure. However, using this variability to represent only the effect of the chromatographic step, overestimates certainly its relative contribution in the whole uncertainty budget of the analytical procedure. The contribution of each chromatographic factor was evaluated using the validation data and other information. As a result, the influence of the chromatographic step of an HPLC analytical procedure was shown depend essentially to the integration error, which is frequently observed in samples of low amount of analyte. While the effects of the other chromatographic factors were shown insignificant, according the retention time variability. In fact, the retention time is obviously influenced by the change in the column temperature, the flow rat and the mobile phase composition.


315

PO-184 Contribution of The Chromatographic Step in The Uncertainty of an HPLC Analytical

Procedure

O Djellouli a, b, E Rozet c, H Bensaoula b, B Dahmani b, P Hubert c

a University Centre of Naama, BP 66, 45000 Algeria b Laboratory of Spectrochemistry and Pharmacology Structural, University of Tlemcen, BP. 119, 13000

Tlemcen, Algeria c Laboratory of Analytical Chemistry, CIRM, Institute of Pharmacy, University of Liège, CHU, B36, Tour 4, Avenue de l’Hôpital 1, B-4000 Liège, Belgium


The main chromatographic factors that affect the precision of the HPLC response (peak area) are the detection, the flowrate, the mobile phase composition, the column temperature,the baseline drift and the baseline noise.

While the instrument response is the ultimate result of HPLC analytical procedure, its corresponding variability (assessed from the validation data), outlines the influence of all sources of uncertainties relating to the entire earlier steps of the procedure. However, using this variability to represent only the effect of the chromatographic step, overestimates certainly its relative contribution in the whole uncertainty budget of the analytical procedure.

The contribution of each chromatographic factor was evaluated using the validation data and other information. As a result, the influence of the chromatographic step of an HPLC analytical procedure was shown depend essentially to the integration error, which is frequently observed in samples of low amount of analyte. While the effects of the other chromatographic factors were shown insignificant, according the retention time variability. In fact, the retention time is obviously influenced by the change in the column temperature, the flow rat and the mobile phase composition.

316

PO-185 Synthesis of Novel α-Aminoacids Bearing 1,2,4-Triazinone and Steroidal Moieties as

Enzymatic Affects (Cellobaiase Activity) – Part II

Dina Abed Bakhotmah

Department of Chemistry, Faculty of Science, King Abdul-Aziz University, Jeddah, Saudi Arabia, E-Mail: [email protected]

Abstract: Novel α-amino acids bearing 1,2,4-triazinone and steroidal moieties (N,C-disubstituted glycine) (5a and 5b) and the related systems (6 and 7) have been produced from condensation of 6-(8-aminophenyl)-4-phenyl-3-thioxo-1,2,4-triazin(2H)-5-one (1) with the selective steroids, 5-α-Androstan-17β-ol-3-one (2a) and Transandrosterone (2b) followed by addition of hydrocyanic acid and acidic hydrolysis. A nucleophilic substitution of mercapto group by 4-fluoro aniline and sulfanilamide of 5 afforded the corresponding α-amino acids 6 and 7. These newly synthesis compounds are further evaluated as enzymatic effects against some fungi (Cellobiase activity)

6a , 6b

7a , 7b

OH

O

N

NHN

Ph

O S

NH2

+ or

1

2a

2b

1

34

17

OH

O6

17

5

N

NH

N

Ph

O

HN

OH

2

4 5

3

19 17'

6

N

NH

N

Ph

O

HN

OH

2

45

3

17'

6

78

78

1

2

1

F

HO2C

H2NO2S

HO2C

Scheme 1. Nucleophilic displacement of mercapto group by 4-fluoroaniline (6a and 6b) or sulfanilamide (7a and 7b).

References

1. R. Abdel-Rahman, J. Morsy, H. Allimony, W. Abdel-Monem,. Synthesis of 3-(1,2,4-triazin-3-yl)-1,2,4-triazine derivatives and their effect on cellobiase activity. Boll. Chim. Farm., 1999, 138(4), 176.

2. D. Bakhotmah. Synthesis of new 6-spiro (testosterone-3’-yl)-hexahydro-3-thioxo-1,2,4-triazin-5-ones and related derivatives as affecting enzymatic agents. Current Org. Synthesis, 2015, 12, 372-375.

3. M. Makki, D. Bakhotmah, R. Abdel-Rahman, M. El-Shahawy.Int. J. Org. Chem., 2012, 2, 311. 4. R. Abdel- Rahman. Phosphorus Sulfur Silicon Relat. Elem., 2000, 166, 315. 5. M. Makki, R. Abdel-Rahman, M. El-Shahawy, Synthesis and Voltammetric Study of Some New Macrocylis of Arsenic (III) in

Wastewater and as Mol-luscicidal Agents against Biomophalaria Alexandrina Snails. Comptes Rendus Chimie, 2012, 15, 617

317

PO-186 Using The Catalytic System Consisted of Seokar -600 and Its Mixture with Halloysite

Nanotube for Thermocatalytic Conversion Heavy Gasoil and Its Mixture with Cotton Oil

Tarana Mammadova, Elmira Asgarova, Nadira Hasankhanova N.V., Natavan Asgarli, Narmin Safarova

Institute of Petrochemical Processes of Azerbaijan National Academy of Sciences, Baku, Azerbaijan Abstract:

The investigations are carried out in most of the countries for increasing the yields of low molecular olefins, especially ethylene and propylene in the conducted deep catalytic cracking. In the presented work has been investigated the thermocatalytic conversion process of heavy gasoil obtained from catalytic cracking process (CCHG) and its mixture with cotton oil at temperature range of 550-700°C. The catalytic conversion process of heavy gasoil and its mixture with 10% of cotton oil have been conducted in laboratory microdevice with the mass rate of 0,5-1 hour-1 of feedstock supplying. Seokar-600 (I) and its mixture with halloysite (II) has been taken as a catalyst. The main catalyst has contained the amount of halloysite of 10% mas.

When the Seokar-600 /halloysite catalytic system is used the upper layer has been consisted of pure halloysites (approximately 5% of the height of catalyst layer), but the bottom layer of catalyst has been consisted of Seokar-600. The composition of hydrocarbon gas obtained from the catalytic cracking process of heavy gasoil and its mixture with cotton oil given below : the maximum yield of ethylene at 700°C in the presence of Seokar-600 and Seokar-600/halloysite mixture catalysts is accordingly of 23,8-24,4 %; but it is accordingly of 17,1-17,7 % mass in propylene. The increasing of the yield percent of olefins is observed when we add halloysite to the composition of Seokar-600 that used for all of the investigated temperatures.

When adding in the heavy gasoil 10% cottonseed oil the maximum yield of ethylene at 700°C in the presence of Seokar-600 and Seokar-600/halloysite mixture catalysts is accordingly of 26,7-27,4, %; but it is accordingly of 18,0-18,8 % wt. for propylene.

The increase of 0,4-0,8; 1,5-0,9; 3,1-3,9; 2,9-3,0 % wt. in the yield of ethylene has been observed during the thermocatalytic conversion of CCHG at with adding 10% of cotton oil at a temperatures of 550-700°C in the presence of Seokar-600 and Seokar-600/halloysite mixture catalyst accordingly . This increase for propylene is accordingly of 0,8-0,7; 1,1-0,7; 1,4-1,5; 0,9-1,1 % wt.

318

PO-186 New Catalytic System with Halloysite Nanotube for Thermocatalytic Conversion Heavy

Gasoil and Its Mixture with Cotton Oil

Tarana Mammadova , Elmira Asgarova, Nadira Hasankhanova N.V., Natavan Asgarli, Narmin Safarova

Institute of Petrochemical Processes of Azerbaijan National Academy of Sciences, Baku, Azerbaijan

Abstract:

The investigations are carried out in most of the countries for increasing the yields of low molecular olefins, especially ethylene and propylene in the conducted deep catalytic cracking. In the presented work has been investigated the thermocatalytic conversion process of heavy gasoil obtained from catalytic cracking process (CCHG) and its mixture with cotton oil at temperature range of 550-700°C. The catalytic conversion process of heavy gasoil and its mixture with 10% of cotton oil have been conducted in laboratory microdevice with the mass rate of 0,5-1 hour-1 of feedstock supplying. Seokar-600 (I) and its mixture with halloysite (II) has been taken as a catalyst. The main catalyst has contained the amount of halloysite of 10% mas.

When the Seokar-600 /halloysite catalytic system is used the upper layer has been consisted of pure halloysites (approximately 5% of the height of catalyst layer), but the bottom layer of catalyst has been consisted of Seokar-600. The composition of hydrocarbon gas obtained from the catalytic cracking process of heavy gasoil and its mixture with cotton oil given below : the maximum yield of ethylene at 700°C in the presence of Seokar-600 and Seokar-600/halloysite mixture catalysts is accordingly of 23,8-24,4 %; but it is accordingly of 17,1-17,7 % mass in propylene. The increasing of the yield percent of olefins is observed when we add halloysite to the composition of Seokar-600 that used for all of the investigated temperatures.

When adding in the heavy gasoil 10% cottonseed oil the maximum yield of ethylene at 700°C in the presence of Seokar-600 and Seokar-600/halloysite mixture catalysts is accordingly of 26,7-27,4, %; but it is accordingly of 18,0-18,8 % wt. for propylene.

The increase of 0,4-0,8; 1,5-0,9; 3,1-3,9; 2,9-3,0 % wt. in the yield of ethylene has been observed during the thermocatalytic conversion of CCHG at with adding 10% of cotton oil at a temperatures of 550-700°C in the presence of Seokar-600 and Seokar-600/halloysite mixture catalyst accordingly . This increase for propylene is accordingly of 0,8-0,7; 1,1-0,7; 1,4-1,5; 0,9-1,1 % wt.

319

PO-188 Processing of Pyrolysis Liquid Products withUsing of New Catalytic Complex

H.J.Ibrahimov, M.I.Rustamov, Z.M.Ibrahimova, K.M.Gasimova, R.H.Ahmadova, I.V.Kolchikova

Institute of Petrochemical Processes, Azerbaijan National Academy of Sciences 30,

Khojaly Ave., Baku, AZ1025

In the world the production of low olefins, especially ethylene and propylene are being produced via pyrolysis of hydrocarbon and during this process along with purposeful gas hydrocarbons, liquid products of pyrolysis (LPP) are obtained, too.

From literature it is known that for the production of high purity marketable benzene in modern petrochemical industry pyrocondensate are being used, for this benzene-toluene-xylene fraction (BTX) with boiling temperature of 70-150° is separated from pyrocodensate. Separated BTX-fraction is processed passing step by step the stages of hydropurifying, hydroalkylation, hydrodesulfurisation and hydrocracking in order to convert contained in its composition unsaturated hydrocarbons. In the first stage– for the avoiding ofsaturation of diolefinsandpolymerization in selective hydrogenation, the process is carried out over the delicatemetals (palladium overaluminumoxide) in liquid phase or over the nickelcatalystat relatively lowtemperature(120°C). In the secondstage - hydrogenation process of olefinand sulfurcompounds effectively carried out,not touching aromatic hydrocarbons in deep hydrogenation, over Mo, Co, W, Nioxidesorsulfides at 250-380°C- and3-5MPa, 1 h-1space velocity.

During processing, unsaturated hydrocarbons are converted into saturated and also turn to gaseous state, which causes incomplete usage of pyrocondensate resources. Moreover, because of coke formation over the catalyst, regular catalyst regeneration is required.

Creation ofnew, non-traditional,advantageous and complex processing scheme is actual not only for Azerbaijan, but also for the development of oil-chemistry in global scale.

In the presence of new homogeneous catalytic complex CTC-1, which is characterized with high persistent activity, oligomerization of non-saturated carbohydrates, contained in pyrocondensate takes place, and consequently 98-99 percent conversion of non-saturated carbohydrates to valuable oligomers (oil-polymer resins) is achieved.

This method, compared with traditional processing of pyrocondensate, has less stages and shows 100% processing depth. End products are marketable, and pyrocondensate of C5 fraction does not require additional processing.

In our suggested method, for the selective treatment of unsaturated hydrocarbons of liquid pyrolysis products, used catalytic complex in the base of aluminum and dichloroethane accelerates the oligomerization of olefins in processing process, leads to narrowing molecular weight distribution of obtained oil-polymer tar, also increasing of molecular mass (M=1000-1100 g/mol) and ultimately achieving of high selectivity to olefins.

320

PO-189 Oxidative Dehydrogenation of Cyclohexanol to Cyclohexanone over Modified Zeolite

A.M. Aliyev, M.G. Aliyeva, Z.A. Shabanova, G.A. Alizade

Institute of Catalysis and Inorganic Chemistry named after M.F.Nagiyev of Azerbaijan National Academy of Sciences


Abstract: Cyclohexanone is an intermediate for the synthesis of caprolactam and adipic acid, which are used in the production of polyamide material nylon 6 and nylon-66. It also finds use as a solvent for fats, dyes, nitrates, natural and synthetic resins and others. In the present study, it has been investigated the catalytic activity of the modified cations Sn2+, Pd2+, Cu2+ and Fe3+ natural zeolite clinoptilolite and faujasite type zeolite in the reaction of gas phase oxidation of cyclohexanol to cyclohexanone by air oxygen. On the basis of experimental studies have shown that the modified natural clinoptilolite as a single input thereto from elements and containing any combination of them, is active in this reaction. It has been found that with a combination of clinoptilolite cations therein tin, palladium and copper in amounts of 0.5; 0.15; 05 wt.%, Respectively, is an active and selective catalyst for this reaction.The experimental data suggest that based on modified synthetic faujasite type zeolites and natural clinoptilolite can be developed efficient catalytic systems for the oxidative conversion of cyclohexanol to cyclohexanone.It has been investigated the kinetics of the reaction of oxidative dehydrogenation of cyclohexanol to cyclohexanone over CuPdSn-clinoptilolite catalyst (0,5% Cu2+, 0,15% Pd2+, 0,5% Sn2+), at different temperatures (260-370oC), space velocities (1036-3109 h-1) and partial pressures of cyclohexanol (Palcohol)=0.06-0.24 atm. and oxygen (PO2)=0.05-0.24atm. It was found that the yield curve of cyclohexanone by the partial pressures of reactants has an extreme character. Maximum yield of cyclohexanone is observed at a temperature of 350°C and Palcohol= 0,12atm. and PO2 = 0.18 atm. Based on these results, a scheme of the reaction of oxidative dehydrogenation of cyclohexanol has been suggested:

OH

+1/2O2

-H2O

O

+1/2O2

-H2O

O

-H2O

8.5 O2

6CO2+5H2O

CH3

+8.5O2

6CO2+5H2O

../Downloads/[email protected]

321

PO-190 Studies of the Catalytic Activity of the Modified Zeolite in the Oxidative Dehydrogenation

of Methylcyclohexane Aliev A.M., Shabanova Z.A., Karimov A.I., Najaf-Guliyev U.M.

Institute of Catalysis and Inorganic Chemistry named after M.F.Nagiyev of Azerbaijan National Academy of SciencesE-mail: zumrud-042425-

@mail.ru

Abstract: The high content of naphthenic hydrocarbons of various fractions Baku oil, creates objective conditions for widespread use of these hydrocarbons as a feedstock for such processes. An important trend in the development of synthetic jet fuels is the use of unsaturated cyclic hydrocarbons in their synthesis. From this point of view, the synthesis of valuable product – methylcyclohexadiene-1,3 by oxidative dehydrogenation of methylcyclohexane has an important theoretical and practical significance.This report presents the results of studies on the oxidative dehydrogenation of methylcyclohexane to methylcyclohexadiene-1,3 on modified synthetic and natural zeolites. Zeolites used in this work were modified a number of metal cations (Zn, Cu, Co, Cr, Mn, Fe, Mg, Mo, etc.) that are introduced into the zeolites by ion exchange sequence. The resulting catalyst was activated by blowing air at temperatures 300-350 ° C and tested on a laboratory flow reactor installation site which was directly linked to the chromatograph. The activity of the catalysts was studied in the investigated temperature range 280-3900S, space velocity 1000-3000 h-1 and a molar ratio of methylcyclohexane:O2: N2 = 1: (0,24 ÷ 1): 5.3.As a result of research into oxidative dehydrogenation of methylcyclohexane in the crystalline aluminosilicate it found that the direction of the reaction is significantly affected by the structure of the zeolite, the nature of the cation introduced and the reaction conditions.Thus, if faujasites depending on the nature of the cation exchange reaction are towards deep oxidation or oxydehydrogenation with formation of toluene, the alkali cations form the synthetic zeolites type A, a natural clinoptilolite and mordenite oxidative dehydrogenation of methylcyclohexane is stopped at the formation methylcyclohexene. Low selectivity of faujasite for methylcyclohexenes can be explained by the fact that strong adsorption of methylcyclohexane on these zeolites leads to its more profound transformation in the inner cavities of the zeolite. At the same time narrow porous zeolites due to reaction on the external surface of zeolite crystals formed intermediate cycloolefins desorbed into the gas phase and not have time to be dehydrogenated to toluene. It was found that, among cationic forms of the zeolites highest yield methylcyclohexen observed on natural clinoptilolite. We have developed active catalyst based on clinoptilolite with its modification with metal cations and under optimal conditions (T=3900C, V=2000 h-1, C6H12:O2:N2=1:1:5.3) on this catalyst selectivity for the target the product is 33.9%, with 53.6% conversion of cyclohexane.Thus, by varying the structure and composition of zeolite over a wide range, it is possible to change the direction of the conversion of methylcyclohexane to solicit relevant desired product. This versatility and selectivity makes the prospect of the use of crystalline aluminosilicate in the oxidation catalysis.



322

PO-191 Chromatographic Separation of Enantiomers Acids Using Macrocyclic-glycopeptid

Bonded Phase CSPS

A. Hamdi *, N.Bouchair**, M.Righezza*** * USTHB , Faculty of chemistry, Bab Ezzouar,Algiers, Algeria

**Jijel University,Faculty of chemistry,Jijel,Algeria ***Aix-Marseille University, Marseille,France

Abstract In the present studies, the chromatographic behavior of some racemic non-steroidal anti-inflamatory drugs (NSAIDS), and mandalic acid, using vancomycin as stationary phase is described. The mandalic acid enantiomers and some NSAID enantiomers were separated in mobile phase systems consisting of the following mixtures. MeOH : Amonium nitrate, 5mM, PH=5 : 40:60 %v/v and MeOH : acetate buffer, 5mM, PH=5:50:50 %v/v, flow rate 0.6ml/min using a UV detector wavelength at 254nm. Keywords: Vancomycin, enantio separation, Mandelic acid, NSAIDS, HPLC References: F.Barbato, C.Carpentiero, L. Grumetto, M.I. La Rotonda, Eur. J. Pharm. Sci.38 (2009) 472.

B. Kafkova, Z. Bosakova, E.Tesarova, P. Coufal, A. Messina, M. Sinibaldi, Chirality 18 (2006) 531. J.L.H. Johnson, S.H. Yalkowsky, AAPS. PharmSciTech. 7 (2006) 33.

323

PO-192 Effective Method for Obtaining Methyl Ethyl Ketone

Rena Ağayevaa ,Fuad Ağayeva, Ağadadaş Əliyeva

aDepartment of Heterogen Catalisis, Istitute of Catalisis and Inorganic Chemistry, National Academy of Sciences of Azerbaijan, Baku, Azerbaijan

E-mail: [email protected] Methyl ethyl ketone is used as solvent and extractant in some cases superior to acetone - less volatile and safer to fire relation. On an industrial scale methylethylketone prepared by oxidation of butylenes and PdCl2 on a two-step method, which consists of n-butene hydration in 2-butanol with a catalyst in a sulfuric acid and oxidative dehydrogenation of sec-butanol to methyl ethyl ketone on mixed oxide catalysts [1-2].The aim of this paper is the selection of an active and selective catalyst for the reaction of partial oxidation of 2-butanol in one of the most important products of the chemical industry, methyl ethyl ketone and the study of kinetics and mechanism of reactions involving the active zeolite catalyst. It has been investigated catalytic activity of zeolite, CaA modified by ion exchange method with cations; Cu2+, Zn2+ and Pd2+ in the reaction of oxidative dehydrogenation of 2-butanolinto methylethylketon in range of; temperature, 240–3500C, space velocity, 1500–

4000 h-1 and partial pressures of; 2-butanol, P=0.12–0.36 atm, oxygen, P=0.12–0.24 atm, at atmospheric pressure. Catalysts were prepared on the basis of CaA zeolite synthesized by the method of ion exchange from NaA. Modification zeolite with metal Cu, Zn, and Pd cations were performed by ion exchange in aqueous solutions of CuCl2, ZnCl2 and [Pd(NH3)4]Cl2 followed by drying (80-1200C, 5 hours) and calcining in flowing air at a temperature of 3000C, space velocity 2400 h-1 for 30 min. The amount of metal cations introduced into the zeolite was determined by mass spectrometry analysis instrument ICP-MS Agilent 7700.It found that the reaction of oxidative dehydrogenation of 2-butanol to methyl ethyl ketone on the synthesized catalysts accompanied by deep oxidation and dehydration of 2-butanol to form carbon dioxide and butylenes. The yields of individual products are significantly affected by the distribution of acid sites (administered metal cations into the zeolite acid site distribution changes on the surface), the concentration and the nature of the cation.Introduction of cations in the zeolite creates favorable distribution of acidic sites on the surface of the catalyst for this reaction. Further the concentration of these cations increases the dissociatively adsorbed oxygen molecules. It has been established, that metalzeolite catalyst CuZnPdCaA containing 3.0 wt.% - Cu2+, 2.0 wt.% - Zn2+ and 0.1 wt.% - Pd2+ shows relatively high activity and selectivity in the reaction. Kinetic laws of this reaction were investigated over the metalzeolite catalyst CuZnPdCaA said composition in the absence of diffusion inhibition. On the basis of the experimental data it has been suggested mechanism and developed the kinetic model of the reaction.Developed a kinetic model of the reaction subjected to statistical analysis based on kinetic data. Calculation of kinetic parameters by the method of "rolling admission" and Powell using software system "Search".Developed a kinetic model of the reaction of oxidation of secondary butyl alcohol to methyl ethyl ketone adequately describes the experimental data. References:

1. Karina L.N., Davudov A., Osipova N.A. //V International Symposium Relations between Homogeneous and Heterogeneous Catalysis. Novosibirsk. 1986. P. 140.

2. Santaceraia E., Gelora D., Danice P.// J.Catalysis.1983.V.80.P.427.

324

PO-193 Metal-Containing Nanocomposites on the Basis of Isotactic Polypropylene*

Nushaba Kurbanova, Nahida Alimirzoyeva

Institute of Polymer Materials of Azerbaijan National Academy of Sciences, Sumgait, Azerbaijan, e-mail: [email protected]

Abstract: Recently it is appeared a considerable interest to composition materials on the basis of polymer matrices and nanosize metals particles, which has been stipulated by wide spectrum of their application – from catalysis to nanotechnology in the information technique, and also in many fields of chemistry, physics and material science [1,2]. In this work we have studied the influence of small additions of metal-containing nanofillers (NF) including nanoparticles (NP) of copper, nickel and iron oxides stabilized on polymer matrix, on peculiarities of properties of thermoplastic elastomer of mixture (TPE) and dynamically vulcanized (TPV) on the basis of isotactic polypropylene (PP) and ethylene propylene diene elastomer (EPDR). In the composition of EPDR the diene component was 5-ethyliden-2-norbornene in a quantity of 4-5%. A ratio of initial components (mass p.) is : PP/EPDR/NF =50/50/1. The new composites on the basis of PP/EPDR with application of NP of copper, nickel and iron oxides have been prepared. The physical-mechanical, electrical, heat-physical and thermal properties and also X-ray-analysis of the prepared nanocomposites have been carried out. It has been shown that a small addition of NF in a quantity 1 of mass p. practically does not influence on crystallinity and dielectric permeability of TPE and TPV but decreases their modulus of elasticity. The obtained data of electrical properties of TPE correspond to indices of usual dielectrics. DSC thermogramms showed that an introduction of NP in TPE practically does not influence on melting temperature of mixtures but leads to the increase of beginning temperature of thermooxidative destruction by 30-50ºC, which evidences about more high thermal stability of the prepared nanocomposites. *This work is supported by a grant (Project Number: SDF-Mob-1-2013-1(7)-16/13/4) from Scientific Development Fund by the

President of Azerbaijan Republic.

References

1. A.D.Pomogaylo, A.S.Rozenberg, I.E.Ufland, Nanoparticles of metals in polymers, M.:Khimiya,2000, 672.

2. N.I.Kurbanova, N.A.Alimirzoyeva, A.N.Kuliyev, T.I.Medintseva, O.P.Kuznetsova, E.V.Prut, European Applied Sciences, 2014, 4, 100-103.

325

PO-194 Synthesis of Self-Extinction Polyesters on The Basis of Polybromobicyclic Dicarboxylic

Acids Raisa Ismayilova, Aga Mustafayev, Eldar Ramazanov

Institute of Polymer Materials of Azerbaijan National Academy of Sciences, Sumgait, Azerbaijan, e-mail: [email protected] Abstract: Requirements for fire resistant polymeric materials and the scope of their application determine the actuality of investigations of preparation of new unsaturated polyesters and composition materials on their basis with necessary complex of physical-mechanical properties. In this connection in this work the results of two-stage method of synthesis and investigation of some regularities of formation of new polybromine-containing polyester maleianates on the basis of 1,4,5,6,7,7-hexabromo- and 1,4,5,6,-tetrabromo-7,7-dimethoxybicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acids with maleic anhydride and polymethylene glycols or glycol-containing ethylene oxide groups are presented. An essence of method is that at the first stage of anhydrides of two-basic acids and glycols the oligoesters containing only end hydroxyl groups are synthesized. At the second stage the prepared oligoester interacts as diol with maleic anhydride on scheme:

(1 stage )

(2 stage )

HO R

OCCH = HCCOOR CO OROOCCH = CH CO

, , , ,R = (CH CH2) (CH2)4(CH2)3(CH2)2(CH2)6

CH3

+

Br

Br

Br

Br

CO

O

CO

CX

XOH Br

Br Br

Br

COC

C

X X

OROH

O

OCOORH

CO

O

CO

Br

Br Br

Br

C

C

X X

O

O

X =Br, OCH3

The influence of nature of glycols on reaction kinetics has been studied, the rate and degree of completeness have been determined. It has been shown that the polybromine-containing polyester maleinates form the compositions with improved physical-mechanical indices and self-extinction properties at hardening with styrene.

References

1. N.R. Bektashi, A.M.Mustafayev, I.A.Guseinov, S.G.Mustafayev, V.J.Jafarov, J.Applied Chemistry (Russia), 2011,84, 7, 1211-1217.

326

PO-195 Study of Interactions Mixtures (Biodegradable Polymer / Active Ingredient) Obtained by

Different Methods of Preparation

Rebiha Damiche, Baitiche milad

Laboratoire des Matériaux Polymères Multiphasiques (LMPMP), Département de génie des procédés, Faculté de technologie, Université de Sétif 1, 19000, Algérie.

[email protected] Abstract: The Niflumic acid is a non-steroidal anti-inflammatory drug (NSAID) and a poorly water-soluble derivative of nicotinic acid with relatively low bioavailability. So, the present paper is devoted to the preparation of new formulations based on the combination of niflumic acid and the beta-cyclodextrin in order to optimize its pharmaceutical and physic-chemical properties. The effect of beta-cyclodextrin on the aqueous solubility and dissolution rate of niflumic acid was studied and elucidated. The binary systems of the compounds (1:1) molar ratios were prepared by different methods and the inclusion complexes were characterized by FTIR, XRD, and UV. The interaction between niflumic acid and ß-cyclodextrin in solution was studied by phase solubility analysis. The results of this study revealed that the complexation of niflumic acid with ß-cyclodextrin can improve the therapeutic efficacy of the drug through the greater efficiency of the drug dissolution. Key words: ß-cyclodextrin, complexation, niflumic acid, phase solubility.

327

PO-196 Selectivity of CDK1 and CDK2 Inhibitors by Heuristic Approach

Aleksandar EFTIMOSKIa, Mejra BEKTASEVICc, Elvisa HODZICc,

Slavica ERICb, Halid MAKICc

aHemofarm A.D., Beogradski put bb, 26300 Vršac, Srbija bFaculty of Pharmacy University of Belgrade, Vojvode Stepe 450, 11000 Beograd, Srbija

cBiotechnical Faculty University of Bihac, Luke Marjanovica bb, 77000 Bihac, BiH [email protected]

Abstract: Cyclin-dependent kinase inhibitors (CDKI) are shown to inhibit tumor growth, as CDK’s are important

regulators in cell cycle. Exploring the molecular descriptors that are the most important for activity of particular CDKI’s, it is possible to get an insight in structural features determining the selectivity of various CDKIs on

individual CDKs subtypes, which could be useful for their further optimization. In this work, a heuristic method implemented in CODESSA software has been used for calculation and selection of molecular descriptors determining activity of CDKIs on CDK1 and CDK2 subtypes. The most important descriptors for activity on both CDKs subtypes belong to the group of topological and quantum chemical descriptors. For activity on CDK1 alone, some descriptors derived from geometry of the molecules have also been selected, for example polar charged surface areas. Those findings indicate the difference in the geometry of ATP binding sites between those two CDKs subtypes. Besides, the different order of topological and quantum chemical descriptors important for activity on CDK1 and CDK2 subtypes, could give us direction for further analysis of selectivity of CDKIs, by including X-ray structures of CDK1 and CDK2 ATP binding sites.

328

PO-197 Diosgenin Bearing Heterocycles Fused to the A-ring of the Steroid Nucleus

Khaled Shawakfeh; Hussein Al-Mughaid Department of Applied Chemical Sciences, Jordan University of Science and Technology, Irbid, Jordan

Abstract:

Due to its potential application as anti-microbial, anti-inflammatory hypotensive, hypocholesterolemic and diuretic activities,

several diosgenin bearing heterocycles fused to the A-ring of the steroid nucleus were prepared. In this research, different

heterocylic fragments fused to diosgenin were prepared, such as pyrazole (5, 6), isoxazole (8), and pyrimidine diosgenin (9, 10).

The functionality on Diosgenin(1) permits for selective functionalization and derivatization either on ring A or ring D. The ketone (2)

undergo condensation with ethylorthoformate to give 2-ethoxymethylene derivative (3). The diosgenin fused pyrazole (5) was

synthesized by dehydrative cyclization with hydrazine in the presence of ethanol and acetic acid. Similarly, isoxazole derivative (7)

was synthesized by reacting (3) with hydroxylamine hydrochloride in the presence of sodium ethoxide. Using the same

methodologies and starting from the 2-bis(methylthio) derivative (4), a methylthiopyrazole derivative (6) and methylthioisoxazole

derivative (8) were synthesized respectively. To synthesize a six-membered ring heterocycles fused to diosgenin, compound (3) and

(4) reacted with guanidine nitrate in the presence of sodium ethoxide and ethanol and give the ethoxypyrimidine dertivative (9),

and the mercaptopyrimidine derivative (10), respectively.

O

O

HO

Me

Me

MeMe

Jones reagent

O

O

Me

Me

MeMe

O

Ethyl orhoformate

O

O

Me

Me

MeMe

O

R1

R2

Hydrazine hydrateAcetic acid

O

O

Me

Me

MeMe

NX

OrNaOEt/EtOH andhydroxylamine hydrochloride

Carbon disulphide, t-BuOKbenzene

Or

3: R1 = H, R2 = OEt4: R1 = R2 = SCH3

5: X = NH, R = H6: X = NH, R = SCH37: X = O, R = H8: X =O, R = SCH3

R

NAOEt/EtOHGuanidine nitrate

O

O

Me

Me

MeMe

N

N

R

H2N

9: R = OEt10: R = SH

12

329

PO-198

Hydroxyalkyl derivatives of diethyldithiocarbamic acid as a hardener for polyethylene-oligomer compositions

Valeh Jafarov, Alverdi Kerimov, Nadir Alekperov, Arzu Orujova

Institute of Polymer Materia;s of Azerbaijan National Academy of Sciences, Sumgait, Azerbaijan, e-mail: [email protected]; [email protected]

Abstract: For achievement of high exploitation and technological indices the compositions of type polymer-oligomer mixtures often contain the epoxide oligomers and corresponding hardeners as the modifiers. However, a formation of net-structures in this case often leads to the deterioration of rhelogical properties of compositions melts. From this point of view it is the most advisable an application of “pseudo-hardeners” in the similar mixtures leading, basically, to the increase of oligomer chain with formation of linear thermoplastic structures. From our point of view the functional derivatives of N,N-diethyldithiocarbamic acid of total formula are of interest:

C2H5

N

C2H5

C SR

S

R=HO(CH2)4 (I), HOCHCH2 - (II)

CH3

-where

(HADEDC I, II)

The similar compounds find an application as the additives for lubricating oils, additions to polymer compositions, etc. The synthesis of derivatives of diethyldithiocarbamic acid, as a rule, is carried out in a medium of ethyl alcohol [1]. We have developed the method of synthesis of these compounds in aqueous medium with high yields [2]. In connection with assigned task, we have studied the thermal behaviour of the synthesized compounds in a mixture with epoxy diane resin ED-20 (30 mass parts HADEDC per 100 mass parts of ED-20.

The results of thermogravimetric investigations showed that on curve DTA (I) there are observed two exothermal effects with maximum at 160ºC and 250ºC, while as DTA curve (II) is presented only by effect at160ºC. It has been experimentally shown that at temperature 160ºC it is observed an intensive interaction between HADEDC (I) and ED-20, as a result of which a thermoplastic mass solidified at room temperature is formed. A nature of the second exo-effect is in need of further investigation. The obtained results have been checked on polyethylene compositions.

References

1. A.c. 1065396 USSR, B.I.,1984, 1. 2. A.c. 845424 USSR, B.I.,1981, 25.


330

PO-199

Synthesis and Characterization of Perylene Derivatives for Liquid Crystal Display Black Matrix of Low Dielectric Constant*

Woosung Leea, Sim Bum Yukb, Jae Pil Kimb aICT textile & Apparel R&D Group, Korea Institute of Industrial Technology, Ansan-si, Gyeonggi-do

bDepartment of Material Science and Engineering, Seoul National University, Seoul, Korea Abstract: For liquid crystal display black matrices of low dielectric constant, organic dyes with low electrical conductivity have recently been suggested as replacements for Cr/CrOx and carbon black. Three organic dyes based on perylene structure with broad absorption spectra were designed and synthesized, and hybrid-type black matrix including dye and carbon black together was fabricated using one of the dyes. The spectral and thermal properties of the dyes were tested by UV-Visible spectroscopy and thermogravimetric analysis. Furthermore, the optical and dielectric properties of the fabricated black matrix were examined by optical density measurement and impedance analysis, and the surface of the black matrix was investigated using field emission scanning electron microscopy. The hybrid-type black matrix showedpromising results with high optical density, low dielectric constant and high pattern-sensitivity.

Figure 1.Synthesized perylene derivatives *This work was supported by a Grant-in-Aid(No. EO150029) for the Topical hemostats based on cellulose derivative from the Korea Institute of Industrial Technology

References

1. W. Lee, S. B.Yuk, J. Choi, D. H.Jung, S. Choi, J. Park, J. P. Kim,Dyes and Pigments.2012, 92,942-948. 2. J. Choi, W. Lee, J. W. Namgoong, T. Kim, J. P. Kim,Dyes and Pigments.2013, 99,357-365. .

331

PO-200 Modified Activated Carbon for The Removal of Cadmium(II) and Zinc(II) from

Wastewater

N. Bouchenafa-Saïb a, O.Mohammedib, N. Madania,c,B. Hamadac, O. Cherifi c.

aLaboratoired'analysefonctionnelle des procédéschimiques, Faculté des sciences de l’ingénieur,

UniversitéSaadDahlab B.P 270 Route de Soumaa Blida Algérie bLaboratoire de chimie physique moléculaire et macromoléculaire, Université de Blida, B.P. 270 route de

Soumaa, Blida, 09000 Algérie claboratoiresynthèsepétrochimique, Faculté des Hydrocarbures et de la Chimie, UniversitéM'hamedBougara,

Avenue de l'Indépendance, 35000 - BoumerdèsAlgérie

Presenting author: [email protected] Abstract: Heavy metals have a harmful effect on human physiology and other biological systems when they exceed the tolerance levels [1]. Heavy metals are not biodegradable and tend to accumulate in living organisms, causing various diseases and disorders.This studyinvestigates the adsorption of cadmium and zinc on commercial activatedcarbon (CAC) that has undergone surface modification with potassium hydroxide (ACB) and nitricacid (ACA) in wastewater applications. The CAC, ACB and ACA werecharacterized by Boehm titration and point of zero charge. The adsorption experiments of metal ions onto adsorbentswerestudiedusing the batch technique and factorsaffecting the adsorption capacitiessuch as agitation time, metal ions concentration and pH wereinvestigated and discussed. The adsorption data wascorrelated to Langmuir and Freundlich isotherm for eachmetal ion and the data fittedbetter to the Langmuir isotherm model. A combined ion exchange, complex formation and surface adsorption processeswerebelieved the major adsorption mechanismsplayingrole in the binding of metal ions. References 1. Babarinde, N. A., Oyebamiji, J., &Sanni, R. A. (2006). Biosorption of lead ions fromaqueous solution by

maizeleaf. 2. Bulut, Y. (2007). Removal of heavymetalsfromaqueous solution by sawdust adsorption. Journal of

Environmental Sciences, 19(2), 160-166.


332

PO-201 The Hydrogenation of p-Chloronitrobenzene Over Pd-M/C Catalysts

N. Bouchenafa-Saïb a, O.Mohammedi b, N. Madania,c,B. Hamadac, O. Cherifi c.

aLaboratoired'analysefonctionnelle des procédéschimiques, Faculté des sciences de l’ingénieur,

UniversitéSaadDahlab B.P 270 Route de Soumaa Blida Algérie bLaboratoire de chimie physique moléculaire et macromoléculaire, Université de Blida, B.P. 270 route de

Soumaa, Blida, 09000 Algérie claboratoiresynthèsepétrochimique, Faculté des Hydrocarbures et de la Chimie, UniversitéM'hamedBougara,

Avenue de l'Indépendance, 35000 - BoumerdèsAlgérie Presenting author: [email protected]

Abstract: The liquid hydrogenation of p-chloronitrobenzene (p-CNB) to p-chloroaniline (p-CAN) has been investigated over a series of oxide and carbon supported Pd catalysts (5 ± 2%, w/w) in aqueous solution at atmospheric pressure (T = 303 K, PH2 = 1 atm). A deposition precipitation method has been employed to prepare the catalysts, leading to well-dispersed palladium particles by immersing activated carbon in a dispersion of Pd fine particles [1]. The reaction was operated in a kinetic-controlled regime. The following activity sequence has been determined: Pd-Co/C >Pd-Mn/C> 5 % Pd/C >Pd-Cr/C, 3% Pd/C, as an alternative catalyst, delivered an appreciably higher activity led to p-CAN as main product with aniline as byproducts. These results seem to indicate that the reaction proceeds through an electrophilic attack.

Reference 1. M. L. Toebes, J. A. van Dillen and K. P. de Jong, J. Mol. Catal. A. Chem., 173, pp. 75–98 (2001)


333

PO-202 Reactivity of Quinoline Derivatives

Khaled MESBAHa, Salah RHOUATIa

a Laboratory of natural products of plant originand organic synthesis, Department of ChemistryUniversity of

brothers Mentouri Constantine.

[email protected]

Abstract

The quinoline derivatives such as 2-chloro- 6-nitro- 3formylquinoline , play an important role in the

synthesis of poly- heterocyclic molecules, the latter having some very interesting structures that can lead to

biologically active molecules similar

References

1. R. Devakaram, D.St.C. Black, N. Kumar Tetrahedron Letters, 2012, 2269-2272 2. Y.M. Chang, Y.S. Park, S.H. Lee, C.M. Yoon Tetrahedron Letters, 2004, 9049-9052

Key words: quinoline, vilsmeier, isoquinoline, NMR

334

PO-204 A Novel Synthesis of 7,8-Dihydrocinnoline-5(6H)-ones by Cyclocondensation of Balis-

Hillman Adducts of Arylglyoxals

Bagher EFTEKHARI-SISa, Maryam ZIRAKb aDepartment of Chemistry, University of Maragheh, Maragheh 55181-83111, Iran.

bDepartment of Chemistry, Payame Noor University, Iran [email protected]; [email protected]

Abstract: Compounds containing an cinnoline moiety have been shown to possess a broad range of biological activities, such as: anticancer, fungicidal, bactericidal, and anti-inflammatory properties.1 Therefore, the synthesis of cinnoline derivatives is of interest.2 In the recent years, the chemistryt of α-Ketoaldehydes and α-ketoesters in the synthesis of heterocyclic compounds has been attracted great attention.3-4 Also, the Baylis–Hillman (BH) adducts have been illustrated as suitable starting materials for the synthesis of variety of heterocyclic systems.5 Here we wish to report a novel three steps approach for the construction of dihydrochinnoline-5(6H)-ones starting from BH reaction of cyclohexenone with arylglyoxals to give corresponding BH adducts, which underwent acetylation using Ac2O in DCM in the presence of DMAP, followed by cyclocondensation with hydrazine hydrate in EtOH under air atmosphere and reflux condition.

Scheme 1.Synthesis of dihydrochinnoline-5(6H)-ones

References

1. W. Lewgowd, A. Stanczak, Archiv der Pharmazie2007, 340, 65–80. 2. N. Haider, W. Holzer, Sci. Synth.2004, 16, 251–313. 3. B. Eftekhari-Sis, M. Zirak, Chem. Rev.2015, 115, 151–264. 4. B. Eftekhari-Sis, M. Zirak, A. Akbari, Chem. Rev.2013, 113, 2958–3043. 5. D. Basavaiah, A. Jaganmohan Rao, T. Satyanarayana, Chem. Rev.2003, 103, 811–890.

335

PO-205 Application of 5,6-Diphenyl-3-(pyridin-2-yl)-1,2,4-triazine as an Efficient Ligands in Pd-

Catalyzed Heck Reaction Bagher EFTEKHARI-SISa, Maryam ZIRAKb

aDepartment of Chemistry, University of Maragheh, Maragheh 55181-83111, Iran. bDepartment of Chemistry, Payame Noor University, Iran [email protected]; [email protected]

Abstract: The Mizoroki–Heck reaction,1 palladium-catalyzed olefination of aryl halides, has become one of the most powerful methods for carbon–carbon bond formation in organic synthesis.2-3 Phosphine ligands are commonly used in the Heck reaction, which suffer from some disadvantageous such as environmental problems, moisture and air-sensitivity, high toxicity and cost of phosphine ligands. Therefore, the development of new phosphine-free catalytic systems for Heck reaction would be an interesting subject, which among them imidazoles play an important role. Recently, we have reported Heck reaction using PdCl2/3-aroyl-4(5)-arylimidazole catalytic system, which afforded corresponding Heck products in good to excellent yields.4 The results encouraged us to work on the Heck reaction using easily prepared and air and moisture stable 5,6-diphenyl-3-(pyridin-2-yl)-1,2-4-triazine I, which was prepared by cyclocondensation of 2-pyridylamidrazone with benzil in EtOH under reflux condition. 2-Pyridylamidrazone was synthesized by heating a solution of hydrazine with pyridin-2-carbonitrile in EtOH.

Scheme 1.Synthesis of triazine I and its application in Heck reaction

References

1. R. F. Heck, J. P. Nolley, Jr., J. Org. Chem.1972, 37, 2320–2322. 2. H. A. Dieck, R. F. Heck, J. Am. Chem. Soc.1974, 96, 1133–1136. 3. A. B. Dounay, L. F. Overman, Chem. Rev.2003, 103, 2945–2964. 4. M. Amini, S. M. Amini, B. Eftekhari-Sis, A. Keivanloo, Turk. J. Chem.2014, 38, 547–552.


336

PO-206 BiCl3-Catalyzed Three-Component Synthesis of 10-Aryl-7,8-dihydropyrano[3,2-

b]chromene-4,9(6H,10H)-diones Maryam ZIRAK

Department of Chemistry, Payame Noor University, Iran [email protected]

Abstract: Molecules containing a kojic acid core exhibited a broad range of biological activities such as antifungal, antineoplastic, antiproliferative, anti-HIV, anticonvulsant, anti-inflammatory, antioxidative, antibacterial, and tyrosinase inhibitory activities.1-2 Therefore, the synthesis of new compounds based on kojic acid is of interest.3 Moreover, Bi(III) compounds have attracted much attention due to their low toxicity, low cost, good stability, and higher catalytic activity. The use of Bi(III) salts as catalysts in organic synthesis is well documented.4-6 In continuing our studies and works on heterocyclic chemistry, which were recently published as two review articles in CHEMICAL REVIEWS,7-8 herein, we wish to report an efficient method for the synthesis of 10-aryl-7,8-dihydropyrano[3,2-b]chromene-4,9(6H,10H)-diones by reaction of kojic acid, an aldehyde and dimedone in the presence of BiCl3 as catalyst under solvent-free conditions at room temperature.

Scheme 1.Synthesis of 10-aryl-7,8-dihydropyrano[3,2-b]chromene-4,9(6H,10H)-diones

References

1. J. Bransova, J. Brtko, M. Uher, L. Novotny, Int. J. Biochem. Cell Biol.1995, 27, 701–706. 2. A. Beelik, Adv. Carbohyd. Chem.1956, 11, 145–183. 3. M. Zirak, B. Eftekhari-Sis, Turk. J. Chem.2015, 39, 439–496. 4. N. M. Leonard, L. C. Wieland, R. S. Mohan, Tetrahedron2002, 58, 8373–8397. 5. H. Gaspard-Iloughmane, C. Le Roux, Eur. J. Org. Chem.2004, 2517–2532. 6. R. Varala, M. M. Alam, S. R. Adapa, Synlett2003, 67–70. 7. B. Eftekhari-Sis, M. Zirak, Chem. Rev.2015, 115, 151–264. 8. B. Eftekhari-Sis, M. Zirak, A. Akbari, Chem. Rev.2013, 113, 2958–3043.

337

PO-207 Selective Oxidation of Sulfides by a Novel Iron(III) Complex Containinga N,O- Type

Bidentate Oxazoline Ligand

Mojtaba Amini,1 Reza Masomi Jahandizi2 1Department of Chemistry, Faculty of Science, University of Maragheh, Maragheh, Iran.

2Department of Biology, Faculty of Science, University of Maragheh, Maragheh, Iran. Abstract: Selective oxidation of sulfides to sulfoxides is an essential step of many biological and industrial processes, leading to sulfoxides, playing the role of essential intermediates since then, anumber of methods have been developed for conversion ofsulfides into sulfoxides [1, 2]. Reaction of Fe(acac)3 and 2-(2'-hydroxyphenyl)oxazoline (Hphox) as a bidentate O, N donor ligand afford a six-coordinated iron(III) complex [Fe(phox)2(acac)] with the distorted octahedral configuration. Complex, [Fe(phox)2(acac)] was isolated as an air-stable crystalline solid and fully characterized by elemental analysis, FT-IR, solution electrical conductivity, and finally by single-crystal X-ray structure analysis.

Figure 1.ORTEP diagram of the complex Oxidation of sulfides to their corresponding sulfoxides was conducted by this catalyst using urea hydrogen peroxide (UHP) as an oxidant at room temperature under air. The catalyst shows very efficient reactivity in the oxidation reactions giving high yields and selectivities.Easy preparation, mild reaction conditions, high yields of the products, short reaction time and high selectivity make this catalytic system a useful method for oxidation reactions.

References

1. M. Amini, M. M. Haghdoost, M. Bagherzadeh;Coord. Chem. Rev.2014, 268, 83-100. 2. V. Palermo, G. P. Romanelli, P. G. Vázquez, J. Mol. Catal. A: Chem., 2013, 373, 142-150.

http://www.sciencedirect.com/science/article/pii/S0277538709003167

http://www.sciencedirect.com/science/article/pii/S0277538709003167

338

PO-208 Novel thiazoline -Copper and Palladium Complexes as Efficient Antibacterial Agents

Reza Masomi Jahandizi,1 Mojtaba Amini,2

1Department of Biology, Faculty of Science, University of Maragheh, Maragheh, Iran. 2Department of Chemistry, Faculty of Science, University of Maragheh, Maragheh, Iran.

Abstract: Synthesis of CuII and PdII complexes containing 2-(2'-Hydroxyphenyl)-2-thiazoline as a bidentate O-N donor thiazoline ligand (tzol), [Cu(tzol)2] (1), [Pd(tzol)2] (2) and their characterization by various techniquessuch as IR, mass spectrometry, and elemental analysis are reported. The structures of complexes 1and 2 were analyzed by density functional theory.The representative synthetic procedureinvolves the reaction of metal acetate with corresponding ligand in methanol.

Figure 1.The optimized structures of complexes 1 and 2computed at B3LYP level of theory. Two complexes [Cu(tzol)2] and [Pd(tzol)2] have shown moderate to good antibacterial activity against Gram-positive and Gram-negative bacteria. Inthisstudy the most potent activity was observed in Pd(II) complexagainst all tested strains when compared to respective standarddrugs streptomycin and ampicillin

References

1. B. Geeta, K. Shravankumar, P. M. Reddy, E. Ravikrishna, M. Sarangapani, K. K.Reddy, V. Ravinder;Spectrochimica Acta Part A, 2010, 77, 911–915. 2. S. Mekahlia,B. Bouzid; Physics Procedia, 2009, 2, 1045–1053.

339

PO-209 Preparation and Chracteristics of Hemostatic Nanofibrous Sheets Containing Blood

Clotting Agents Eun Jung Sim1, Sun Jong Kim2, Eun Jin Kim2, Insu Baek2, and Oh Hyeong Kwon1*

1Department of Polymer science and engineering, Kumoh National Institute of Technology 2Institute of Interventional Medicine, M.I.Tech Co., Ltd., South Korea

Email: [email protected]

Abstract:

Hemostatic agents have been used in surgical operation for many years to control bleeding because the body is unable to control massive blood loss without treatment. Some hemostatic agents are often ineffective, expensive or raise safety concerns [1]. In this study, we fabricated poly(vinyl pyrrolidone)(PVP) nanofibrous mats containing blood coagulation agents such as calcium chloride and thrombin to use as a novel non-woven hemostatic agent. PVP is biocompatibility and safe material approved by FDA for human use [2]. PVP nanofibrous sheets were fabricated by electrospinning of 10 wt% PVP aqueous ethanol solution containing thrombin and calcium chloride. Electrospun PVP nanofibrous mat structures revealed randomly aligned fibers with average diameter of 580 nm. Surface characteristic of PVP nanofibrous mats were confirmed to be soluble and hydrophilic surface determined by water contact angle measurement. Cytotoxicity of PVP nanofibers showed the cellular survival rate was more than 90%. In vitro whole blood coagulation experiment showed expeditious blood coagulation, because thrombin and calcium chloride are evenly dispersed on PVP nanofibrous sheet and released upon contacting with blood.In vivo animal study reported more effective the nanofibers than surgicelⓇ.These results suggest that electrospun PVP nanofibrous mats containing clotting agents will be a promising hemostatic agent to reduce massive blood loss.

Figure 1.Schematic illustration of hemostatic agent

References

1. A. M. Behrens, M. J. Sikorski, T. Li, Z. J. Wu, B. P. Griffith, P. Kofinas;Acta Biomaterialia.2014,10,701-708.

2. H. M. Mansour, M. J. Sohn, A. Al-Ghananeem, P. P. DeLuca; International Journal of Molecular Sciences.2010, 11, 3298-3322.

340

PO-211

Cr-Substituted Ni-Zn Ferrites via Oxalate Decomposition, Structural, Electrical and Magnetic Properties

M.A. Gabal a, Y.M. Al Angarib, F.A. Al-Agelc

Chemistry department, Faculty of Science, King Abdulaziz University, Jeddah, KSAa,b,c

Abstract A series of Cr-substituted Ni-Zn ferrites; Ni0.8Zn0.2CrxFe2−xO4 (x = 0.0–1.0) were prepared via oxalate decomposition route to characterize the effect of Cr-substitution on structural, magnetic and electrical properties. The prepared powders were characterized using X-ray diffraction (XRD), Fourier transform infrared (FT-IR) and transmission electron microscopy (TEM). XRD indicated single-phase cubic ferrites. The lattice parameters (aExp) exhibited a gradual decrease with increasing chromium, attributed to the smaller ionic radii of Cr3+ substituent. According to the obtained structural data, an appropriate cation distribution was suggested and fortified through FT-IR spectroscopy besides magnetic and electrical measurements. TEM image showed agglomerated cubic crystals with an average size of about 20 nm. Vibrating sample magnetometer (VSM) measurements indicated minimal hysteresis characteristic for soft magnetic material. The decrease in saturation magnetization (Ms) with Cr-substitution was discussed in view of Neel’s two sub-lattice model. The change in the coercivity with Cr-content was discussed in view of estimated cation distribution and magnetization values. The obvious fall in the Curie temperature, estimated from molar susceptibility measurements, with increasing Cr-concentrations was assigned to the gradual replacement of Fe3+ ions on the octahedral sites by paramagnetic Cr3+ ions. ac-conductivity as a function of both frequency and absolute temperature exhibited a semi-conducting behavior. The decrease in conductivity with increasing Cr-content was attributed to the preferential occupation of Cr3+ ions by octahedral sites which replacing Fe3+ ions and limiting Fe2+–Fe3+ conduction.

The figure illustrated the variation of the saturation magnetization as well as the coercivity on the amount Cr substitution. From the figure, it is obvious that, the saturation magnetization decreases gradually with increasing Cr-substitution while coercivity increases Keywords: Cr-substitution; NiZn ferrite; susceptibility, hysteresis; conductivity. *E-mail:[email protected]


341

PO-212

Nature of Steel Substrate Effect on Intermetallic Compounds of Coatings Obtained by Galvanization

Younes BENARIOUAa , Didier CHICOTb

aDépartement de Génie Mécanique, Faculté de Technologies, Université de M’Sila, BP 166 - M'Sila 28000, Algérie. bUniversité Lille Nord de France, Lille1, LML, UMR 8107, F-59650 Villeneuve d’Ascq, France.

Abstract: In the last few years, the use of galvanization coating as material treatment to improve notably the chemical properties of steel parts has shown a large and extensive development. Zinc and some of its alloys have a number of characteristics that make it well suited for use as a protective coating against the corrosion of steel substrates under severe atmospheric conditions[1-3]. The metal of zinc, which represents the main galvanization element offers then a cathodic protection to the ferrous materials. Because of these excellent characteristics, galvanization coatings are expected to be used for different protective applications fields. The aim of this research work is to study the effect of nature of steel substrates on intermetallic compounds of galvanization coatings obtained at different immersion time. Steels substrates to be coated in this case are used in agriculture field as tubes and irrigation elements in pivot. After an optimal preparation of the surface of the substrate by an appropriate roughness process, the steel specimen were immersed in a molten zinc bath maintained at 450 °C. The chemical reactions which take place between the steel and the liquid zinc

give rise to the formation of the and intermetallic compounds and the -Fe/Zn solid solution. The structures of the intermetallic compounds are analyzed by X-ray diffraction and optical observations. The morphology and thickness of phases coated the different steel substrate are then controlled by scanning and optical microscopy. The hardness of coatings was measured with a Vickers hardness tester with different loads.

References

1. A.R. Marder, Progress in Mater. Sci. 45, 2000, 191-271. 2. P. Bicao, W. Jianhua, S. Xuping, L. Zhi, Y. Fucheng, Surf. Coat. Technol. 202 , 2008,1785-1788. 3. C.E. Jordan, A.R. Marder, J. Mater. Sci. 32 , 1997, 55-93.

342

PO-213

Zn-Cr Co-substitution Effect on the Structural and Magnetic Properties of Nano-sized CuFe2O4 Synthesized via Oxalates Decomposition Route

M.A. Gabal

Chemistry department, Faculty of Science, King Abdulaziz University, Jeddah, KSA Abstract

In this manuscript, Zn-Cr co-substituted Cu1-xZnxFe2-2xCr2xO4 ferrites (where x = 0.0 - 0.5) were successfully prepared via the

thermal decomposition of their respective oxalates precursors. The thermal decomposition of the precursors up to ferrites

formation was followed by DTA-TG measurements. XRD, FT-IR and TEM were used to characterize the produced ferrites. Mössbauer

technique was used to predict the possible cation distribution of the entire system and the results were confirmed via XRD, FT-IR

and electromagnetic measurements. The Superparamagnetic characteristics estimatedvia Mössbauer studies, for samples with

higher substitution, are in agreement with the results obtained using VSM, magnetic susceptibility and conductivity measurements.

All the samples showed semi-conducting properties with conductivity decreasing by increasing substitution. The effect of cationic

substitution on the entire system was investigated and discussed.

*Corresponding author. E-mail address:[email protected] Telephone: 00966557071572 Permanent address:Chemistry Department, Faculty of Science, Benha University, Benha, Egypt.


343

PO-214

Application of Multivariate Curve Resolution Alternating Least Squares (MCR-ALS) to the Quantitative Analysis of Food Colorants using Spectrophotometric Acid-base

Titrations

Masoumeh Hasania, Masoud Shariati-Radb , Elahe Bidada

aFaculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran, [email protected] bDepartment of Chemistry, Razi University, Kermanshah, Iran

Abstract: To resolve multicomponent systems informative experimental data that can be organized in a matrix are needed. To obtain such data matrices, chemical process can be monitored in a multivariate fashion. MCR-ALS is an iterative soft-modelling resolution method which decomposes a bilinear data matrix with mixed information about a multicomponent system into the product of two small matrices of pure component spectraand the relative concentration profiles [1-3]. In this study, an acid-base titration approach has been used for obtaining second-order data to the quantitative determination of mixtures of food colorants, amaranth, sunset yellow FCF, and tartrazine. Using an appropriate arrangement of the data, the colorants were quantified accurately using multivariate curve resolution-alternating least squares (MCR-ALS). The quantitative determination of these compounds in different synthetic mixtures and in some real samples has been performed using only a synthetic external standard solution of the analyte of interest. The method was applied to the determination of these compounds in saffron, saffron ink and orange soft drink with satisfactory results. Good recoveries were obtained in the range of 98–108%. Based on the second-order advantage of the method applied, the determination of the analytes of interest will be possible in complex samples.This method avoids the need to use a large number of calibration samples for analyzing mixtures.

References

1. Saurina, J.; Hernandez-Cassou, S.; Tauler, R.; Izquierdo-Ridorsa, A. Anal Chem.1999, 71, 126. 2. Izquierdo-Ridorsa, A.; Saurina, J.; Hernandez-Cassou, S.; Tauler, R. Chemometr Intell Lab.1997, 33,515. 3. Diewok, J.; deJuan, A.; Tauler, R.; Lendl, B.Appl Spectrosc. 2002, 56, 40.

344

PO-215

Spectroscopic Study of Charge Transfer Complexation between Some Benzimidazole Drugs and Picric Acid

Ohoud Hassan Al-Mohamady

Departments of Chemistry, Girls College of Education, King Abdul-Aziz University, Jeddah, Saudi Arabia

Abstract: Donor-Acceptor complexation reactions between albendazole (ABZ) and febandazole (FBZ) as electron donors with picric acid (PiOH) as electron acceptor have been investigated spectrophotometrically in chloroform (CHCl3) as a solvent. The molecular composition of the new CT complexes have been estimated by Job’s and photometric titration method to be 1:1 ratio (donor:acceptor). The formation constants (KCT) and molar extinction coefficient (ε) have been estimated using the modified Benesi-Hildebrand equation. Moreover, the CT reaction was used in a sensitive and simple spectrophotometric method to determine ABZ and FBZ. Beer’s law was obeyed in the concentration range (7.0 -186 μg /mL) for ABZ and (8.0-210 μg /ml) for FBZ with high correlation coefficient. The recovery percentages ranged between (99.24 to 99.42) %, with relative standard deviations ranging (0.93 - 1.09).

345

PO-216

Development and Validation of a Stability˗Indicating RP- HPLC Method for Determination of Sofosbuvir in Bulk and Pharmaceutical Dosage Forms

Tamer Awad Ali*a, Gehad G. Mohamedb, Ali A. Aglanc, Fakiha El-Taib Heakalb

a Egyptian Petroleum Research Institute (EPRI), 11727, Cairo, Egypt. b Chemistry Department, Faculty of science, Cairo University, 12613, Giza, Egypt.

c Memphis Company for pharmaceuticals and chemical industries,11281, Cairo, Egypt.

Abstract: A simple, selective, precise and accurate isocratic stability indicating RP- HPLC method was developed and validated for simultaneous determination of sofosbuvir in pure and tablet dosage form. The chromatographic separation was achieved on a Lichrospher 60 RP select B (5 μm), LichroCART ® 125 mm х 4 mm HPLC Cartridge analytical column using a mixture of 0.05 % triflouroacetic acid in 5 % methanol as solvent (A) and 0.05 % of triflouroacetic acid in 95 % methanol as solvent ( B ) in the ratio of

(52 : 48 v/v). The optimal instrumental settings are flow rate of 1.5 mL min-1, column temperature 35 C, and detector wavelength of 260 nm. The retention time of sofosbuvir was 4.2 min. The method was validated according to the ICH guidelines acceptance criteria for specificity, linearity, precision, recovery, ruggedness, and robustness. The linearity range was performed from 40 to 160 % with respect to the test concentration strength. The correlation coefficient obtained was 0.9998. The mean % recovery of the drug was found to be in the range of 98 to 102%. The drug undergoes degradation under acidic, basic, peroxide, thermal and photolytic degradation conditions. All the peaks of degraded products were resolved from the active ingredient with significantly different retention time. The proposed method was suitable for quantitative determination and stability study of sofosbuvir in pharmaceutical preparations and also can be used in the quality control of bulk manufacturing and pharmaceutical dosage forms. The method can be employed as stability - indicating one for the drug.

Scheme1.Chemical structure of sofosbuvir .

http://en.wikipedia.org/wiki/File:Sofosbuvir.svg

346

PO-217

Synthesis of New Stable Verdazyl Radical Ekaterina MARTYNKOa, Pavel PETUNINa, Pavel POSTNIKOVa, Marina TRUSOVAa

aTomsk Polytechnic University, 634050, Tomsk, Russia Abstract: Free radicals are widely used in organic chemistry [1]. One of their types are stable verdazyl radicals 1a,b. It can be used as magnetic materials [2], as ligands for metal complexes formation [3]. The most common method of synthesis is formation of verdazyl cycles from 1,3,5-substituted formazanes 2:

We have developed a new method of 1,3,5-substituted formazanes synthesisusing stable arenediazonium tosylates (ADT) [4] and appropriate hydrazones:

The new highly stable and acid-resisant verdazyl radical 4 was synthesized from those formazanes via oxidative alkylation.

References

1. I.Ratera, J. Veciana, Chem. Soc. Rev., 2012, 41, 303; 2. B.D. Koivisto, R.G. Hicks// Coordination Chemistry Reviews, 2005, 249, 2612; 3. D.J.R. Brook, C.J. Richardson, B.C. Haller, M. Hundley, G.T. Yee// Chemical Communications, 2010, 46, 6590; 4. V.D. Filimonov, M.E. Trusova, P.V. Postnikov, E.A. Krasnokutskaya, Y.M. Lee, H.Y. Hwang, H. Kim, K.-W. Chi, Org. Lett, 2008, 10, 3961.

347

PO-218

Synthesis, Radical Copolymerization of (p-vinyl phenyl)cyclopropyl-chlorocinnamate with Styrene and Photosensitivity of the Prepared Copolymers

Kazim Guliyev, Afat Aliyeva, Dilbar Nurullayeva, Abasgulu Guliyev Institute of Polymer Materials of Azerbaijan National Academy of Sciences, Sumgait, Azerbaijan; e-mail: [email protected]

Abstract: This work has been devoted to the systematic investigation of influence of functional substituent on photosensitivity of cyclopropane-containing polymer. With this aim the (p-vinyl phenyl)cyclopropylchlorocinnamate (PCCC) has been synthesized, its radical copolymerization with styrene has been carried out and the photosensitivity of the synthesized copolymer has been investigated. PCCC was prepared by interaction of 2-chlorobenzaldehyde with malonic acid, in solution of absolute alcohol in the presence of pyridine. The synthesized copolymer has a following structure:

X

X

+ CH2 CH

CH2OC CH =

nCH2 CH

m

X = CH C6H4Cl

O

AIBN

The structure of the synthesized copolymer has been confirmed by spectral data and chemical analysis. The copolymer is dissolved in benzene, chlorinated hydrocarbons, etc. İt has been revealed that the copolymerization process in the studied conditions proceeds due to the opening of double bond of vinyl group with conservation of the reactive fragments in the side chains of macromolecules. A yield is 85%. The copolymerization constants of copolymerizing monomers are r1 = 1,05, r2 = 0,54. The photochemical investigations of the synthesized copolymer have been carried out. The investigations showed that the prepared copolymer possesses high photosensitivity and can be used as a light-sensitive base for photo-resists in microelectronics. Thus, an availability of cyclopropane group and double bond in macromolecule of copolymer in combination with carbonyl group and chlorine atoms considerably increases sensitivity to UV-irradiation. The photosensitivity in this case is 48,5-52,8 cm2 J-1.

References

1. K. G.Guliyev, G.Z.Ponomaryova, A.M.Guliyev. VMS, B, 2007, 49, 8, 1577-1581. 2. K. G.Guliyev, A.M.Aliyeva, G.Z.Ponomaryova, D.R.Nurullayeva, A.M.Guliyev, American Journal of

Applied Chemistry, 2015, 3, 1, 21-24.

348

PO-219

New Polymer Compositions on the Basis of Mineral Fillers with Appreted Polyolefins

Sevil Bektashi,Gulnara Babayeva,Gulnara Musayeva,Valeh Jafarov Institute of Polymer Materials of Azerbaijan national Academy of Sciences, Sumgait, Azerbaijan, e-mail: [email protected];

[email protected] Abstract: The proposed new class of polymer composition materials (PCM) synthesized according to the radical copolymerization reaction of C6-C8 olefins with maleic anhydride ( MA) and acrylic acid (AA), modified with triple copolymers have been prepared with thermoplastic polymers (polyethylene-PE, polypropylene-PP) on the basis of mineral fillers (zeolite, alunite, azerit, kaolin, etc) that change their amount between 20-60%. These copolymers as appret in modification process and containing numerous functional groups (-COOH, -CHO,-CO, C=C etc), which have been included in polymer matrix consisting of PE, PP increases their reactivity. In this case an increase of estimations of the physical-mechanical properties of created PCM-s, including strength properties, flexibility

parameters (strength (), specific elongation () is observed. Triple copolymer products made according to the radical

polymerization of MA and AA with –C6-C8 series of -olefins, i.e. hexene-1, heptene-1, octene-1 are powder substances molecular

weight (MW) of which is in 50-60 thousand range. As a result of exclusion chromatographic investigations depending on condition of the structure of the same copolymer products 20% low molecular, molecular weight parameters changing in the range of 5000-7000 (Mn) and 6500-9000 (Mn) the unsaturated polyfunctional oligomer products have been observed. The influence of shown copolymers on physical-mechanical properties of filled PCM has been studied individually and tendency of

decrease of strength () and increase of specific elongation () in hexene-1, heptene-1, octene-1 series have been observed. It was also determined that an inclusion of additional polymer connectors to the system increases appret influence of copolymers, i.e. “synergetic” effect is observed. It should be noted that one of the superior features of applied triple copolymer type apprets is that with changing of amount ratios of reaction components in copolymer chain a superiority of any functional group and groups can be provided. This enhances opportunities to get polymer composition materials with previously known properties and exploitation properties changing in wide range. On the other hand, low prices of used raw materials in the preparation of filled PCMs and being inside the republic enhances corresponding application potentials.

References

1. V.J.Jafarov, A.A.Efendiyev, Plast.massy, 2007, 1,28-30.

2. V.J.Jafarov et al. VII Baku Intern.Mamedaliyev Conf. on petrochemistry,2009, 246-247


349

PO-220

Cationic Polymerization of Vinylcyclopropyl Ethers and Photo-Structurization of the Prepared Polymers

Rita Shahnazarli, Abasgulu Guliyev

Institute of Polymer Materials of Azerbaijan National Academy of Sciences, Sumgait, Azerbaijan, e-mail:[email protected]

Abstract: The current development of microelectronics requires constant improvement of characteristics of resists. For creation of such materials there are necessary the new polymers from series of functionally substituted cyclic monomers, on the basis of which it is possible the preparation of polymers with original structural links in the macromoleculechain [1,2]. This work is the development of investigations in the field of cationic polymerization of monomers containing at least two functionalities – double С=С-bond and cyclopropane group. The monomers of series of cyclopropane-containing vinyl ethers have been chosen as an object of investigation:

OO

O

CO2EtCO2Et

O

CO2EtH

ClCl

Scheme 1. Synthesis of the initial monomers.

In work the results of their selective cationic polymerization and photo-chemical conversion of the prepared polymers are presented. The polymerization was carried out in the presence ofBF3∙O(C2H5)2in toluene solution at various temperatures (from -75ºСto -10ºС). It has been shown that the polymerization proceeds exclusively with opening of vinyl group, although it is observed a small quantity of formation of insoluble products:

O

xy

BF3 O(C2H5)2

tolueneO

xy

CH2 CH n

Scheme 2.Scheme of polymerization of the synthesized monomers.

The structure of monomers, prepared polymers and their photochemical conversion were studied by spectral and chemical methods.

References 1. W.M. Moreau. Microlithography,М.:Mir, 1990, 606. 2. R.Z.Shahnazarli, A.A.Aliyeva, Kh.G.Nazaraliyev, A.M.Guliyev. J.AppliedChemistry (Russa),2008,81 (2),

304-307.


350

PO-221

Numerical Study of Natural Convection Heat Transfer Performance in an Inclined Cavity: Nanofluid and Random Temperature

Mohamed SI-AMEURa, Hicham SALHIa, Nadjib CHAFAIb

aLESEI, Department of Mechanical Engineering, University Batna, Algeria e-mail: [email protected] bLaboratory of Electrochemistry of Molecular Materials and Complexes (LEMMC), Department of Process

Engineering, Faculty of Technology, University of FERHAT ABBAS Setif-1, DZ-19000 Setif, Algeria. Abstract: Natural convection of a nanofluid consisting of water and nanoparticles (Ag or TiO2) in an inclined enclosure cavity, has been studied numerically, heated by a (random temperature, based on the random function). The governing equations are solved numerically using the finite-volume. Results are presented in the form of streamlines, isotherms, and average Nusselt number. In addition, a parametric study is carried out to examine explicitly the volume fraction effects of nanoparticles ( = 0.1, 0.2), the Rayleigh number (Ra=103, 104, 105, 106),the inclination angle of the cavity( égale à 0°, 30°, 45°, 90°, 135°, 180°), types of temperature (constant ,random), types of (NF) (Ag andTiO2). The results reveal that (NPs) addition remarkably enhances heat transfer in the cavity especially for ( = 0.2). Besides, the effect of inclination angle and type of temperature is more pronounced at higher Rayleigh number. Keywords: Nanofluid, Natural convection, inclined cavity, random temperature, finite-volume.

351

PO-222

Experimental, DFT calculation, Biological Activity and Anion Sensing Applications Studies of a New Schiff Base (E)-4-[(pyridin-3-ylimino)methyl]benzene-1,3-diol

HÜSEYİN ÜNVERa*, BAHADIR BOYACIOĞLUb, CELAL TUĞRUL ZEYREKc,DEVRİM YOLALa, MUSTAFA YILDIZd

aDepartment of Physics, Faculty of Science, Ankara University, 06100 Beşevler-Ankara, Turkey bVocational School of Health Services, Ankara University, TR-06290 Kecioren-Ankara, Turkey

cAnkara Nuclear Research and Training Center, Turkish Atomic Energy Authority, Besevler-Ankara, Turkey dHealth Services Vocational School, Çanakkale Onsekiz Mart University, TR-17100 Çanakkale, Turkey

dDepartment of Chemistry, Faculty of Arts and Sciences, Çanakkale Onsekiz Mart University, Çanakkale, Turkey. E-mail address:[email protected], [email protected] (H. Unver)

Abstract Synthesis, X-ray crystallographic, Fourier transform infrared (FT-IR) , 1H NMR and 13C NMR spectroscopic studies on (E)-4-[(pyridin-3-ylimino)methyl]benzene-1,3-diol have been studied. Potential energy surface (PES) scans, optimized molecular structure, theoretical vibrational band assignments, molecular electrostatic potential (MEP), nonlinear optical (NLO) effects, Mulliken population analysis, natural population analysis (NPA), UV-vis, natural bond-orbital (NBO) analysis and thermodynamic properties have been also investigated by using density functional theory (DFT) with the functional B3LYP using the 6-311++G(d,p) basis set. The molecular structure obtained from X-ray single-crystal analysis of the investigated compound in the ground state was compared with thoretical results by using Hartree-Fock (HF) and DFT. The molecular properties of the title compound in solvent media were also investigated. The experimental and calculated Fourier transform infrared (FT-IR) of the compound were compared. To investigate the tautomeric stability, some properties such as total energy, HOMO and LUMO energies, the chemical hardness, the ionization potential, the electron affinity, the absolute electronegativity,the absolute softness of the compound were obtained at B3LYP/6-311++G(d,p) level in the gas phase and solvent phase.The calculated results showed that the enol-imine form of the compound was more favorite than keto-amine form. The antimicrobial activities of the compound were investigated for its minimum inhibitory concentration (MIC). The colorimetric response of the Schiff base receptors in DMSO was investigated before and after the addition of an equivalent amount of each anion to evaluate the anion recognition properties.

Keywords: Schiff base; Density functional theory; Antimicrobial activities, Anion sensors, tautomer



352

PO-223 Reactivity of Polybromine-cyclopentadienes and Their Ability to Complexation

A.M.Mustafayev, S.S.Kerimova

Institute of Polymer Materials of Azerbaijan National Academy of Sciences, Sumgait, Azerbaijan, e-mail:[email protected] Abstract:

The spectrophotometric study of the diene synthesis reaction cited in this report showed that during the reaction between electron-acceptor dienes and electron-donor dienophiles the charge-transfer complexes (CTC) of π-π type are formed and besides the diene behaves as π-acceptor, and dienophile as π-donor. In order to clarify the role of complexation during diene synthesis, we have studied these relationships. For this purpose it was conducted a comparison of reactivity of the diene series – hexabromocyclopentadiene (HBC), 5,5-dimethoxy-(DMTBC), 5,5-dioxyethylene-1,2,3,4-tetrabromocyclopentadiene (DETSC) with their electron affinity in the diene synthesis reaction accepting the latter as measure of the capacity the π-acceptors to the formation of CTC. The electron affinity of 5,5-DMTBSC and 5,5-DETBSC were determined by UV-spectra of absorption of charge-transfer complexes of these dienes with N,N,N’,N’-tetramethyl-p-phenylendiamine. It was shown that for absorption spectra of charge-transfer complexes with HBC the self-absorption of addends is not overlaid on the absorption of the complex. In the case of absorption spectrum of CTC with 5,5-DMTBSC and 5,5-DETBSC a maximum of the absorption bands of charge-transfer complexes is in the UV field, where both of components are absorbed extensively. A comparison of the reactivity of these dienes with N-phenylmaleimides showed that the diene activities of these compounds are decreased by increasing their electron affinity.

On the basis of this it can be concluded that in the case of components with the same structure, when determining factors are only electronic effects, it is observed the parallelism between diene activity and its reactivity.

References

1. Aga Mustafayev, Nizami Adigezalov, Vladimir Kiseleev, Alexandr Konovalov, Mustafa Guseynov. Journal of Organic Chemistry (Russia), 1980, 16 (12), 2549-2

353

PO-224 Investigation of Relationship between Formation of Chemotype with Structuring of

Humic Substances in the Forest; Case of Kefken (Kocaeli)

Ali Gürel1, Mehmet Özdemir1, Mesut Tandoğan1, Ömer Beyhan2, İbrahim Halil Baydilek3, Ahmet Tutar3

1Marmara Forestry Research Institute 2Sakarya University, Vocational School of Pamukova

3Sakarya University, Department of Chemistry

Abstract:

Laurel (Laurus nobilis L.) is an aromatic and medicinal plant with antioxidant, analgesic (pain-reliever), anti-inflammatory and anticonvulsant (anti-epileptic) properties that have attracted the interest of pharmacological and food industries. Humic substances (HS) are a natural organic compound that has shown beneficial effects on soil and on plant growth. These positive effects are explained by the direct interaction of HS with physiological processes. But it is unknown the effect of these substances on the composition of the Laurel essential oil constituents (Chemotype). This study was carried out in laurel forest of Kandıra, Sakarya province. Sample areas were selected 3 repeatedly and from 3 different point 220 m above the sea. Plant and soil samples were collected from a sample area. Humus samples were taken from 3 different parts in the humus layer. Soil samples were taken from 15-20 cm of soil depth in the part where the humus layer ends. Leaf samples were taken from the last 2-3 annual shoots of the plant. Essential oil components were analyzed by using distillation in Clevenger apparatus and gas chromatography. IHSS method was used in determining the amount of humic acid and fulvic acid In soil samples. Clustering analysis was performed using the Algortihms Hierarchical Clustering method. Essential oil components were analyzed by using distillation in Clevenger apparatus and gas chromatography. IHSS method was used in determining the amount of humic acid and fulvic acid in soil samples. Clustering analysis was performed using the Algortihms Hierarchical Clustering method. In terms of this study, 19 different volatile compounds were analyzed In laboratory. It was found to be that the main components are Sabinene, 1.8-Cineole, α

-Terpinenylacetat in the cluster analysis dendrograms. As a result of clustering analysis with main components and humic substances; new clusters linked to amount of humic substances and their structuring emerge. Especially, It is seen that it may be effective on the different formation Chemotype depending on the amount of essential oils differences of fulvic acid content in soil organic matter. Keywords: Laurel, votalite compound, chemotype, humic substance, References: 1.Y. Göker ve İ. Acar, İstanbul Üniversitesi Orman Fakültesi Dergisi, Seri:B, Cilt:33, Sayı:1, İstanbul, sayfa:

125, 1983 2.A.Horuz, A. Korkmaz, M.Dizman, A.Tutar, M.R.Karaman, S.Karakaya ; SAÜ Fen Edebiyat Dergisi,14(1):147-158, 2012. 3. M.H. Alma Türkiye' de Orman Tali Ürünleri Ve Kullanım Yerleri, Ders Notları Kahramanmaraş Sütçü

İmam üniversitesi, Kahramanmaraş, 2011

sakarya university department of chemistry...department of chemistry international turkic world...

Documents