saiesh. evaluation softwares

8/13/2019 Saiesh. Evaluation Softwares.

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Tablet Wt variation Enter the wt of the tablets % of Wt variationS.No Individual wt of Tablet *100

1 496 -0.7801560312 498 -0.3800760153 501 0.220044009

4 507 1.420284057

5 505 1.020204041

6 500 0.020004001

7 495 -0.980196039

8 496 -0.780156031

9 504 0.82016403310 500 0.020004001

11 500 0.020004001

12 495 -0.980196039

13 505 1.020204041

14 503 0.62012402515 497 -0.58011602316 496 -0.78015603117 496 -0.78015603118 504 0.82016403319 497 -0.58011602320 503 0.620124025

total wt 9998 9.13714E-14

AVG wt 499.9 4.56857E-15


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Ta et Wt var at on

DevelopersSRINIVAS COLLGE OF PHARMACY, MANGALORE

575001 saieshphaldesai12 @gmail.com Developed by Saiesh Phaldesai

Instructions

Enter the values in "E" column (Light Pink boxes)Get the report from yellow colour column

Report of % of wt variation of 20 tablets

IP & USP LIMITSWt of the tablet % of deviationMore than 325mg 10325-130mg 7.5less than 130mg 5
mailto:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]


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DEVELOPED BY: SA

MAIL ME @ saie


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EVALUATION FORMULARS

IESH P. PHALDESAI B.PHARMA, M.PHARMA

[email protected]


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DevelopSRINIVASsaieshphalde

Instructions

1 Enter the values in blue colored boxes

2 Get report in yellow coloured box REPORT

S.No123456

AVG
mailto:[email protected]:[email protected]


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d By : Saiesh phaldesai COLLGE OF PHARMACY, MANGALORE

[email protected]

Test for FriabilityIntial Weight 4.4Final Weight 4.6% Friability -4.545

Disintegration TimeTime (Sec/Min)

89543443237553


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Creative Head And Work Function By Saiesh Phaldesai :- @ sai

BCP Software : Saiesh Phaldesai

Srinivas College of Pharamacy, Ma

S.No Concentration (ug/ml) Absorbance1 0 02 2 0.1183 4 0.224 6 0.3225 8 0.422

.

Calibration Curve (R2) 0.99918159SLOPE 0.051Unknown Absorbance 0.424Unknown Concentration 8.31372549

Wt of API Taken 200Dilution factor 100Volume of withdrawn 5

Volume of DissolutionMedium 100


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[email protected] and [email protected]

ENTER VALUES IN COLURED COLUMN

galore. Developed by : [email protected]

S.No Time ABS % CDR1 5 0.049 4.803921572 10 0.085 8.335735293 15 0.174 17.06539224 20 0.298 29.23078435 25 0.365 35.8140196

. .

7 35 0.668 65.54450988 40 0.087058829 45 0.08705882

10 50 0.08705882

* No Dilution Factor Enter 1

ENTER VALUES IN COLURED COLUMNS

R = 0.9992

0

0.1

0.2

0.3

0.4

0.5

0.6

0 2 4 6 8 10 12

Calibration Curve

Calibration Curve


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F1 F2 F3 F4


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Time Reference Test Rt-Tt (Rt-Tt)2 |Rt-Tt|60 80 70 10 100 10

120 81.88 80 1.88 3.5344 1.88180 83.11 85 -1.89 3.5721 1.89240 86.31 89 -2.69 7.2361 2.69300 90.04 89 1.04 1.0816 1.04360 94 97 -3 9 3

0 0 00 0 00 0 00 0 00 0 0

N= Rt sum (Rt-Tt)2 sum |Rt-Tt| sum6 515.34 124.4242 20.5

Similarity factor(50-100)= 66.56983 (F2)

Difference factor (0-15)= 3.977956 (F1)


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Developed ByEnter the Time Points Enter the values Srinivas Colle

%CDR saieshphaldesai12@Time (Hr) Log Time SQRT Time % Cumula Release Log % Release

0 0 0

5 0.699 2.236 13.09 1.11715 1.176 3.873 18.83 1.2749

30 1.477 5.477 22.23 1.3469

45 1.653 6.708 27.6 1.4409

60 1.778 7.746 39.94 1.601490 1.954 9.487 45.94 1.6622

120 2.079 10.954 54.36 1.7353

150 2.176 12.247 61.99 1.7923

180 2.255 13.416 81.75 1.9125

210 2.322 14.491 88.79 1.9484

240 2.380 15.492 96.83 1.9860#NUM! 0.000 #NUM!#NUM! 0.000 #NUM!#NUM! 0.000 #NUM!#NUM! 0.000 #NUM!

Zero order PeppasK0(Slope) 0.373278 #NUM!

Report R2 0.9799 #NUM!0.3733

0

20

40

60

80

100

0 4 8 12 16 20 24

% o

f C u m u

l a t i v e D r u g R e

l e a s e

Time (h )

Zero order Release

Zero order Release

2.100 Peppas Model


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The End

y = 0.814x + 0.1052R = 0.964

0.000

0.300

0.600

0.900

1.200

1.500

1.800

-0.500 -0.200 0.100 0.400 0.700 1.000 1.300

L o

g % o

f R e

l e a s e

Log t


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:Saiesh Phaldesai e of Pharmacy - mangalore

gmail.com% Drug remaining Log % Drug remaining

100 2

86.91 1.939 Instructions81.17 1.909 1. Enter the values in Pink color box77.77 1.891 2. Check the System of Release by72.4 1.860 Which is near to 0.999 which fol

60.06 1.779 3. Get the Graphs from down.54.06 1.733

45.64 1.659 Order Graphs38.01 1.580 Zero Order Time vs Drug Releas18.25 1.261 First Order Time vs log % Drug11.21 1.050 Higuichi Model SQRT Time vs % Dru

3.17 0.501 Peppas Model log Time vs log % Dr100 2.000 Graphs (Diplayed at d100 2.000100 2.000100 2.000

Higuichi First Order

-0.005

0.9619 0.8701

K 0.012

100Higuchi Model

y = -0R

0

0.5

1

1.5

2

2.5

0 4 8 12 16 20 24

L o g % C u m u

l a t i v e r e m a i n t o r e e

l a s e

Time (h)

First Order


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y = 6.16R

0

20

40

60

80

0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5 5.5 6 6.5 7 7.5 8 8.5 9 9.51010.51111.51212.51313.51414.51515

% C u m u l a t i v e

d r u g r e

l e a s e

Hig


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es (Time and % Cumulative Drug Release)2 Values.

lows the same system of release

emainingRelease

g Releasewn )

.005x + 2.0739 = 0.8701

First Order


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44x - 6.51740.9619

.51616.5

chi Model


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Edit your Time Points, Fomulation Codes and Release P

% Cumulative Drug ReleaseTime F1 F2 F3 F4 F5 F6 F7

0 1 1 1 1 1 1 8

1 2 4 6 6 6 6 10

2 3 3 3 3 3 3 3

3 4 6 9 14 14 14 14

4 5 5 5 5 5 5 5

5 6 6 6 6 6 6 6

6 7 7 9 9 9 9 9

7 8 10 10 18 18 25 25

8 9 9 14 14 14 14 29

9 10 10 10 10 10 10 10

10 11 11 18 21 21 21 21

11 12 14 14 14 14 14 39

12 13 18 20 26 26 29 29

DevelopBCP Software SRINIVA

SAIESHPHAL


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ofile as per your Study

F8 F98 8

10 10

3 3

14 14

30 5

6 6

9 9

25 46

29 29

10 10

21 21

39 39

29 59

d By : SAIESH PHALDESAI College of Pharmacy [email protected]

0

20

40

60

80

100

0 2 4 6 8 10

% C

u m u l a t

i v e

d r u g r e

l e a s e

Time (h)


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12 14

F1

F2

F3

F4

F5

F6

F7

F8

F9


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% Cumulative drug release

Time F1 F2 F3 F4 F50 0 0 0 01 6

23456789

1011 45

12

BCP Software


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F6 F7 F8 F90 0 0 0

34

Zero Order

Developed By : SAIESH PHALDESAISrinivas College of Pharmacy - [email protected]

0

20

40

60

80

100

0 2 4 6

% C u m u

l a t i v e

d r u g

r e l e a s e

Time


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8 10 12 14

(h)

F1

F2

F3

F4

F5

F6

F7

F8

F9


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Log %Cumulative remain to reelase

Time F1 F2 F3 F4 F5 F61 1.836 1.896 1.9 1.942 1.81 1.814

2 1.829 1.838 1.876 1.933 1.778 1.784

3 1.796 1.808 1.864 1.917 1.756 1.774

4 1.76 1.779 1.848 1.906 1.678 1.715 1.705 1.753 1.832 1.898 1.566 1.641

6 1.69 1.738 1.816 1.876 1.507 1.462

7 1.597 1.683 1.775 1.846 1.312 1.407

8 1.456 1.625 1.718 1.828 1.075 1.135

9 1.753 1.753 1.753 1.753 1.753 1.753

10 1.738 1.738 1.738 1.738 1.738 1.738

11 1.683 1.683 1.683 1.683 1.683 1.683

12 1.625 1.625 1.625 1.625 1.625 1.625

DeveloBCP Software Srinivas

saieshphal


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F7 F8 F91.866 1.938 1.888

1.848 1.931 1.868

1.824 1.921 1.853

1.78 1.903 1.8351.718 1.887 1.825

1.696 1.874 1.803

1.632 1.839 1.76

1.548 1.821 1.708

1.753 1.753 1.753

1.738 1.738 1.738

1.683 1.683 1.683

1.625 1.625 1.625

1st order

ed By : SAIESH PHALDESAI College of Pharmacy - [email protected]

1

1.2

1.4

1.6

1.8

2

2.2

0 1 2 3 4 5 6 7

L o g % C u m u

l a t i v e r e m a i n t o r e

l a s e

Time (h)


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8 9

F1

F2

F3

F4

F5

F6

F7

F8

F9


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Log % Cumulative drug release

LOG T F1 F2 F3 F4 F50 1.496 1.33 1.312 1.096 1.548

0.301 1.512 1.492 1.394 1.154 1.602

0.477 1.572 1.552 1.43 1.246 1.634

0.602 1.637 1.6 1.471 1.29 1.719

0.6989 1.692 1.637 1.51 1.32 1.801

0.778 1.707 1.667 1.538 1.39 1.831

0.845 1.781 1.714 1.61 1.47 1.9

0.903 1.853 1.762 1.68 1.51 1.945

1.637 1.637 1.637 1.637 1.637

1.667 1.667 1.667 1.667 1.667

1.714 1.714 1.714 1.714 1.714

1.762 1.762 1.762 1.762 1.762

BCP Software


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F6 F7 F8 F91.542 1.423 1.125 1.357

1.592 1.469 1.168 1.418

1.608 1.523 1.219 1.457

1.687 1.599 1.3 1.501

1.75 1.677 1.359 1.52

1.851 1.701 1.4 1.562

1.872 1.757 1.491 1.627

1.936 1.811 1.528 1.69

1.637 1.637 1.637 1.637

1.667 1.667 1.667 1.667

1.714 1.714 1.714 1.714

1.762 1.762 1.762 2

Peppas

Developed By : SAIESH PHALDESAISrinivas College of Pharmacy - [email protected]

1

1.2

1.4

1.6

1.8

2

0 0.2 0.4 0.6

L o g % C u m u

l a t i v e

d r u g r e

l e a s e

Log t


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0.8 1

F1 F2

F3 F4

F5 F6

F7 F8

F9


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SQRT F1 F2 F3 F4 F5 F60 0 0 0 01 31.34 21.36 20.45 12.53 35.38 34.83

1.41 32.54 31.08 24.8 14.27 39.96 39.12

1.73 37.35 35.68 26.91 17.62 43.01 40.54

2 42.35 39.86 29.57 19.37 52.33 48.68

2.23 49.23 43.37 32.1 20.8 63.18 56.26

2.44 50.88 45.35 34.51 24.86 67.82 71.03

2.64 60.41 51.79 40.4 29.42 79.49 74.46

2.82 71.36 57.83 47.81 32.63 88.11 86.342.23 32.1 32.1 32.1 32.1 32.1 32.1

2.44 34.51 34.51 34.51 34.51 34.51 34.51

2.64 40.4 40.4 40.4 40.4 40.4 40.4

2.82 47.81 47.81 47.81 47.81 47.81 47.81

% Cumulative drug release

Higuchi

DeveloBCP Software SRINIV

saieshphal


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F7 F8 F90 0 0

26.49 13.32 22.74

29.46 14.74 26.18

33.38 16.56 28.67

39.75 19.94 31.67

47.71 22.86 33.1

50.29 25.1 36.51

57.14 30.95 42.4

64.68 33.74 48.9432.1 32.1 32.1

34.51 34.51 34.51

40.4 40.4 40.4

47.81 47.81 47.81

ed By : SAIESH PHALDESAIS College of Pharmacy [email protected]

0

10

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30

40

5060

70

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100

0 0.5 1 1.5 2 2.

% C u m u

l a t i v e

d r u g r e

l e a s e


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.5 3

F1

F2

F3

F4

F5

F6

F7

F8

F9

saiesh. evaluation softwares

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