RX-10Enhance Your Jacketed Lab Reactor

Beat Dietrich

October 2015

Content

Jacketed Lab Reactor (JLR) Challenges

RX-10 Overview

Voice of the Customer

1

What is a JLR System?

2

Jacketed Lab Reactor

PAT Probe

Stirrer

Temperature

Challenges with Traditional Lab Reactors

3

Inconsistent

Controls

Means time-

consuming task of

relearning controls

Lost or Missing Data

Failing to Document

Leads to Repeat

Experiments

Manual

Documentation

and Reporting

Time Consuming

and Error Prone

Manual Parameter

Control

Scientists must be in

lab to change process

parameters

Increase waste of

materials and time

Lack of integration

Increases risk of

inconsistent results

Inefficient use of

resources and

limited ability to run

safe overnight

experiments

Bottlenecks post

experiment delay

timely decisions

Challenge 1: Inconsistent Controls

Many different interfaces for thermostats. Not easy to use.

If Control Software is Available, a Trained (Dedicated) User is Required to

Operate it

Difficult To Find Replacement People To Run Experiments

4

Multiple Interfaces Increases Risk of Error

Solution 1: One Simple, Standard Interface

5

Integrated Control for all Equipment

- Instantly intuitive

No training required

- Single point of control for major process

parameters (dosing, temperature, stirring)

No need to learn multiple interfaces

One Simple, Standard Interface

Challenge 2: Manual Parameter Control

6

Heat to 70 °CStir at 250 rpm Dose 200 g Chiller failure

ProductivityHow to avoid going back to the

lab for every activity?

SafetyBehavior in case of an

unexpected event?

Take Sample

Wait

Lack Control over Scheduling and Process Safety

Sample Method

Wait Wait

Readjust parameters

Solution 2: Unattended 24/7

7

Program Sequences for Unattended 24/7 Safe Operation

Pre-program Tasks on

Touchscreen or in iControl

- Automated parameter

control means experiments

can be run overnight

- Experiments can be

quickly repeated

Program Safety Limits

- Ensures safe unattended

operation even with an

equipment failure

Challenge 3: Lost or Missing Data

8

Each instrument produces different data that

may not be logged or stored

Lack of integration makes

analysis difficult

Lost Productivity Slows the Pace of Process Optimization

Temperature

pH

Stirring

Solution 3: 100 % Data Capture

9

100 % Data Capture to Understand and Optimize

Live reaction data

trended on touchscreen

or PC

Improve experiment

documentation and

process knowledge

Quickly repeat

experiments based on

previously captured data

Example Reactor Temp Response to Dosing

Quickly Observe Process Data as it Responds to Reaction Conditions

10

Tr (°C)

Vr (mL)

As Dosing Begins, Exotherm is Observed

Te

mp

era

ture

°C

Vo

lum

e (

mL

)

Time (h)

Solution 3: 100 % Data Capture

11

For Advanced

Analysis Using

iControl Software:

Overlap all

reaction

parameters with

dosing trends and

process analytical

data for a full

understanding of

the process

Understand Reaction Kinetics to Improve Process Design

Example Detecting Temp. at Nucleation

Link Process Temperature to ParticleTrack Data to Measure the Temperature

at the Onset of Crystallization

12

Overlap and Identify Process Conditions at Events

Temperature °C

# of particles <50 microns

Dete

ct N

ucle

ation

Measure Temperature

Challenge 4: Documentation and Reporting

Complete Documentation (Description of

Equipment and Recipe) is Difficult and

Very Time Consuming Resulting in Lost or

Inaccurate Information

13

No stirrer speed, temperature or set

point documented (poor

reproducibility)

Data is not digital (information is not

searchable)

Captured in local language (reuse

of knowledge limited to local team)

Poor Reproducibility and Limited Knowledge Sharing

Personal Document, not backed

up or shared

Real Extract from Lab Journal

Solution 4: Powerful Reporting

One-click MS Word/Excel

report documenting the

recipe and equipment.

Drag and drop designer

creates flexible reports

with custom trend graphs

14

Generate accurate history for effective communication

Solution Overview with RX-10

15

Record complete and

accurate process data

for improved

experiment

documentation and

process knowledge

An integrated

controller for all

process chemistry

equipment increases

accessibility and

consistency

Sequences of

automated parameter

controls means

experiments can be

run safely overnight

Quickly prepare

reports for accurate

history and

effective

communicaiton

100 % Data

Capture

One Simple,

Standard Interface

Powerful

Reporting

Unattended 24/7

Content

Jacketed Lab Reactor (JLR) Challenges

RX-10 Overview

Voice of the Customer

16

RX-10 Overview

17

Existing Jacketed

Lab Reactor

RX-10 Base Unit Touchscreen Operation

SmartConnect™

Sensor Port

Third party sensors

such as:

• Reflux temperature

• Mass flow meter

• Pressure sensors

iControl / iC DC

PC-based recipe

control and data

analysis with

PAT integration

• Automated Dosing

• Additional sensors

• Sampling

TrR

S2

32

Network

Accessories

Peripherals

RX-10 at a Glance

18

USB ports

Data Export

Firmware Upgrades

SmartConnect™ sensor port

Plug & play of Pt100,

voltage and current sensors

CAN accessories

Plug & play connectivity

to DU-SP50, EasySampler,

ECB, etc.

Ethernet (Network)

iControl / iC Data Center

Touchscreen port

1 m or 3 m cable length

Thermostat/Stirrer

RS232 port, plug & play

recognition of equipment

Safety relay

Acoustic or visual alerts

Emergency button

To trigger emergency

program

Easy-to-use touchscreen

Basic functions learned

within 60 seconds

SmartConnect™ Cable

SmartConnect Cable

- Smart chip technology automatically recognizes

standard laboratory instrumentation for

immediate control and data collection

No need for added adaptors or specialized setup

time/cost

Moving instrumentation from one vessel to another

is fast and easy

- Connects to:

PT100 (Temperature)

Pressure sensors, Mass Flow Meters

Any Other Analog Sensor with Voltage or

Current Output

RX-10: Technical Specification

20

Thermostats Huber, Julabo – all models with RS232 port.

Stirrers IKA, Heidolph, J-KEM – all models with RS232 port

Temperature Range Full range supported by Huber or Julabo thermostats

(-120 °C – 425 °C)

Volume range / Reactors Choose what is best for your application.

There are no volume or reactor limits given by RX-10.

SmartConnectTM Port

(plug & play)

Pt100 4 wires (RTD)

Voltage -10 V to +10 V

Current 0 to 20mA

Connectivity and data transfer Ethernet: Communication to PC

(iControl/iC Data Center)

CAN: Interface for peripherals (ECB, DU-SP50, EasySampler)

USB: Data Export to USB stick

Supported languages English, German, French, Spanish, Japanese, Chinese

Safety features - Emergency button for immediate execution

of emergency program

- Emergency relay to connect audible or visual alert

Dimensions, W x D x H 70 mm x 152 mm x 215 mm (2.75” x 5.98” x 8.46”)

Weight 2,88 kg, including touchscreen

RX-10: Delivery Scope

21

30208790:

RX-10 with

1m touch-

screen

cable

30217050:

RX-10 with

3m touch-

screen

cable

1 RX-10 main unit 1 1

2 Touchscreen 7’’

(1m cable)1

3Touchscreen 7’’

(3m cable)1

4 Power Supply 1 1

5 Lab Bar Holder 1 1

6Thermostat/Stirrer

RS232 cables1 1

7USB memory stick

2GB1 1

8 iControl DVD 1 1

9 iControl Office License 1 1

10RX-10 Quick Start

Guide1 1

EasyMax 402

100 ml – 400 ml OptiMax

250 ml – 1000 ml

EasyMax 102

1 ml – 400 ml

Synthesis and Process Development Tools

EasyMax and OptiMax are Turn Key Development Workstations

All-in-one System / Minimal Footprint

Reactors are Easy to Change and Easy to Clean

No Need For External Thermostat

Ready-to-Go Reactor Setups

Fast And Stable Temperature Control

Easily Upgrade To Calorimeter

22

Feature Comparison

23

# Feature Standalone JLR RX-10EasyMax /

OptiMaxRC1e

1 All-in-one system / minimal footprint

2 Reactor easy to change/clean

3 No need for external thermostat

4Ready to go reactor setupsfor distillations, pressure, ..

5 Touchscreen to control ALL process params

6 iControl *

7 iC Data Center

8 PAT data integration

9 UCB Universal Control Box (RS485) – PC only

10 EasySampler integration

11 ECB Easy Control Box (CAN plug'n'play)

12 DU-SP50 Dosing Unit (syringe pump)

13 Upgradable to calorimeter

14 RTCal

15 Adiabatic mode

16 Real Tj measurement not T bath of chiller - -

17 Tr-Tj control for distillations / reflux

18 Non-linear ramps for crystallizations

19 Fast and stable T control

20 One-click report

* = iControl recipe exchange possible between RX-10, EM and OM but not with RC1e. iControl for RC1e is a different application.

RX-10 Data Handling

Touchscreen

Easy to use control

in front of the reactor

File transfer and basic evaluation after experiment completion

Data Management

Capture and archive

data

Automated data capture, preparation and sharing

Advanced online/offline evaluation

iControl

PC Software

Advanced control, may be

at a remote location

iC Data CenterUSB / Ethernet

Touchscreen

25

Programming a T Ramp Live Trend Graph

Pre-programming of Up to 6 StepsHomescreen – Learn in 60s

iControl – Powerful PC Software

Easy-to-Use

Advanced Task Programming

Re-run of Experiments

Comprehensive Trend Graph

Intuitive Data Processing

Powerful Reporting Function

Seamless Integration with

METTLER TOLEDO Analytical

Tools

26

iControl – One Software for all Volumes

27

EasyMax 402

100ml – 400ml

OptiMax

250ml – 1000ml

RX-10

>1000ml

EasyMax 102

1ml – 400ml

Small Volume Medium Volume Large Volume

Copy Recipes Between Reactors;

Easily Overlay and Compare Data

iControl – Remote Control from PC

28

Up to 4 Connected Units – RX-10, EasyMax or OptiMax

Drag'n'Drop Recipe Designer

Drag'n'Drop

iControl Introduction Video on YouTube (4min)

RX-10 Laboratory: iC Data Center

Automated Data

Collection with iC

Data Center

- Automatically

Capture, Prepare

and Share data

from variety of

instruments and

transform it into

valuable process

data

- iControl is not

required – data

capture without

the need for a PC

in the lab!

Jacketed Lab Reactor (JLR) Challenges

RX-10 Overview

Voice of the Customer

Content

31

Voice of the Customer

32

Since we installed the RX-10, our jacketed lab reactors are used much more

frequently. It is now easy and intuitive to program, manage and store data, and

interpret experimental results. Safety limits on reactors reduce risk for the whole

lab… In short, RX-10 makes our jobs easier and safer.Andy Huygaerts, Janssen Pharma, Belgium

The RX-10 is a universal Jacket Lab Reactor (JLR) control unit that works truly

plug’n play. My favorite function: It enables basic lab operations such as

temperature, agitation and dosing control as well as data capturing on existing

equipment. A simple entry door into the world of lab automation!Gregor Schock (Grünenthal, Germany)

The RX-10 unit is a versatile solution to optimize scale-up processes. In our

Lab, it has closed the gap between EasyMax/OptiMax Synthesis Workstations

and multi-liter JLR vessels. As main benefits, it provides a consistent lab

workflow to the user and gives documentation of experiments along the whole

scale-up workflow. Dr. Carsten Griebel (Grünenthal, Germany)

Questions?

33

100 % Data

Capture

One Simple,

Standard Interface

Powerful

Reporting

Unattended 24/7

http://

http://www.labtex.co.uk/product/rx-10-reactor-control-data-capture