rosacea - gp cme north/1630 fri room 8 barker - rosacea.pdf · rosacea has increased transepidermal...
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ROSACEA :
CLUES FOR IMPROVED CONTROL
Dr Scott Barker
Consultant Dermatologist
Wellington
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ROSACEA SUMMARY
Chronic Inflammatory skin condition
Common
Exact pathogenesis not known Dysregulation of innate immune system
Overgrowth commensal organisms
Aberrant neurovascular signalling
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Features usually recognised on face
But I have seen features on scalp and chest and neck
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DIAGNOSTIC CRITERIA
Diagnostic criteria for rosacea Presence of at least 2 of the following primary features
Flushing (transient erythema) .....usually first feature
Nontransient erythema
Papules and pustules
Telangiectases
May include the following secondary features
Burning or stinging
Dry appearance
Edema
Ocular manifestations
Peripheral location
Phymatous changes
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SUBTYPES
Erythematotelangiectatic
Papulopustular
Phymatous
Ocular
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ERYTHEMATOTELANGIECTATIC
Episodes of flushing
Persistent central facial erythema
Periocular skin usually spared
Telangiectasis common
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PAPULOPUSTULAR
Features of flushing and erythema
Transient papules / pustules
Facial oedema
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PHYMATOUS
Thickened skin
Surface nodularity
Nose especially
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OCULAR
Watery / bloodshot appearance
Foreign body sensation
Burning or stinging
Dryness
Itching
Light sensitivity
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PATHOGENESIS
Dysregulation of the innate immune system
Microorganisms
Demodex folliculorum,
Stap epidermidis
H pylori
Bacillus oleronius
Neurogenic Dysregulation
UV radiation
Abnormal Barrier function
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TRIGGERS
Stress (emotional / physical)
Temperature change
Hot drinks
Alcohol
UV light
Thick creams / Fragrances
Steroids
Spicy food
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DIFFERENTIAL DIAGNOSIS
Acne
Seb Derm
Perioral dermatitis
Steroid acne
Lupus
Carcinoid syndrome
Dermatitis
……………………………… and many more …………….
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DIFFERENTIAL DIAGNOSIS
Rosacea
Adults
Papules
Pustules
No Comedones
Erythema
Telangiectasias
Acne
Teens
Papules
Pustules
Comedones
No erythema
No telangiectasias
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TREATMENT : PATIENT EXPECTATIONS
Explain no cure
Treatment focused on control
Many treatment options because none universally work
I show the list of options
Focus on
Patient education
Skin Care
Pharmacologic / Procedural interventions
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TREATMENT
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TREATMENT
Patient Education
Triggers
Avoiding topical steroids
Skin Care
Very gentle cleansers.
Moisturisers. Rosacea has increased transepidermal water loss.
A study of metronidazole gel 0.75% alone vs with cetaphil cream showed improved dryness, roughness, desquamation and skin sensitivity.
Sunscreen. At least SPF 30. No specific sunscreen product been found to be most beneficial. Find one that is tolerable, probably best titanium / zinc.
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TREATMENT PHARMACOLOGICAL
Topical Metronidazole
Been used since 1950’s
Decreases ROS
Decreases erythema , papules, pustules when applied daily.
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TREATMENT PHARMACOLOGICAL
Topical Azelaic Acid BD
Decreases Kallikrein 5 and Canthelicidin
Changes microbiome
70 – 80% patients get some improvement
Generally well tolerated.
Build up to twice a day
Very good for acne also. Sometimes useful to put people on after finish isotretinoin.
Very good for erythrasma.
Possible modest depigmentation effect for melasma.
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TREATMENT PHARMACOLOGICAL
Topical Brimonidine 0.5% gel
Alpha-adrenergic receptor agonist, works on smooth muscle cells around dermal plexuses.
Temporary reduction in facial redness
May be very marked.
Some patients love it “miracle cream”
Beware 10% have rebound erythema. Online profile.
Not useful for the large calibre telangiectasis without smooth muscle.
I have found best when used with Azelaic acid.
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BB
Brimonidine gel
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TREATMENT PHARMACOLOGICAL
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TREATMENT PHARMACOLOGICAL
Topical retinoids. Retrieve cream.
Helps dermal remodelling and possibly helps repair UV induced
damage
Particularly good at reducing pustules, papules.
Not as well studied in rosacea. Not my first line.
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TREATMENT PHARMACOLOGICAL
Topical Calcineurin inhibitors : Pimecrolimus
Inhibit T cell activation, reduces inflammation.
Mixed results in studies but well worth a go in conjunction with orals
in refractory cases.
Best I think if there is rosacea and dermatitis.
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TREATMENT PHARMACOLOGICAL
Permethrin Cream 5%
Theoretically to lower demodex
Similar efficacy to metronidazole gel for erythema and papules.
Ivermectin cream 1 %
I’ve not used yet. Very good results in recent trials FDA approved recently.
“Soolantra” Cost ?
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TREATMENT : SYSTEMIC
Tetracyclines
Doxycycline, Lymecycline , Minocyline
Antiinflammatory (lower ROS, inhibit nitric oxide, decrease MMP)
I like to use with Azelaic acid and then after a few months try just on the Azelaic acid.
If have to stay on long term then rotate including with erythromycin
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TREATMENT : SYSTEMIC
Isotretinoin
Low dose long term isotretinoin for papulopustular rosacea or phymatous.
Less likely to have a such a definite end point as when treating acne.
Warn re risk of increased erythema.
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TREATMENT : SYSTEMIC
For Fulminant rosacea / pyoderma faciale ……
Prednisone tapering over 4 – 6 weeks
PLUS erythromycin 400mg PO bd
PLUS Azelaic acid.
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TREATMENT : PROCEDURAL
Laser / IPL
Only option for telangiectasia
Can help general erythema
Several safety issues and patient expectation issues that need to go over.
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WHEN TO REFER
Pyoderma Faciale
Unsatisfied patient
Diagnostic uncertainty
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TIPS
Avoid triggers …. advise keep a diary
Ice in mouth prior to flushing triggers
Sunscreen zinc oxide / titanium dioxide
Soft scarf over face if in wind
Avoid lots of “skin care” creams, fewer products the better
Don’t do ANA with every red face
Try and get control with systemics & creams then withdraw systemics
Avoid rubbing / scrubbing face
Avoid hairspray
Elidel
Triamcinlone injection. Risks.
Beware efudix
Watch out for hidden tumours
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