role of oxidative stress in disease modification
TRANSCRIPT
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A PRESENTATION ON ROLE OF OXIDATIVESTRESS IN DISEASE MODIFICATION
Presented By : Soobiya Majeed
Roll No. 14451S0110 M.Pharm (sem-I)
Pharmacology SUCP
Under the guidance of:Dr. Anupama KoneruM.pharm, ph.DPrincipalSUCP
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CONTENTS
1. INTRODUCTION
2. OXIDATIVE STRESS
3. FACTORS AFFECTING OXIDATIVE STRESS
4.FREE RADICALS
5.OXIDATIVE STRESS AND DISEASES
6. CONCLUSION
7. BIBLIOGRAPHY
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OXIDATIVE STRESS
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen
species and a biological system's ability to readily detoxify the reactive intermediates or to
repair the resulting damage.
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What are free radicals?
Reactive oxygen species
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Free radicals acumulate
damageCELLS
DNALIPIDS SUGARS
PROTEINS
CELL MEMBRANE DYSFUNCTION
DNA DAMAGE
ENZYMEREACTIVATION
PROTEIN RE-MODIFICATION
AGING DISEASES
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OXIDATIVE STRESS AND DISEASES
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OXIDATIVE STRESS AND PARKINSONS DISEASE
lAt the cellular level, PD is related to excess production of reactive oxygen species (ROS), lto alterations in catecholamine metabolism, to modifications in mitochondrial electron transporter lChain (METC) function or to enhancement of iron deposition in the SNpc.
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OXIDATIVE STRESS AND CANCER
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OXIDATIVE STRESS AND CARDIAC FAILURE
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ANTIOXIDANTS
VITAMIN EVITAMIN C
FLAVANOIDSCHLOROPHYLLCAROTENIODS
DISEASES
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ANTI OXIDANTS
1.PREVENTION
2.INTERCEPTION
3.REPAIR
STOP PRODUCTION
COLLECT UNSAFE SPECIES
CONVERT TO SAFER SPECIES
FREE RADICALS
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CONCLUSIONOxidative stress is considered as the major underlying cause of various diseases. It is found that generation of reactive metabolits play a central role in cell’s life. These metaboloites are continuously controlled by endogenous antioxidant enzyme system, which may be enzymatic or non-enzymatic or transitional metals. Thus, the balance is created between pro-oxidants and antioxidants. Reactivemetabolites play important biological functions in calls in a controlled environment. The impairment of antioxidant status, either by exogenous or endogenous sources, may disturb the cellular redox balance and the pathological condition would be the main characteristics and forms oxidative stress in cells and tissues. There by leading to various diseases.
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BIBLIOGRAPHY
1.Basic and Clinical Pharmacology 12/E (Lange Basic Science)
2.Rang & Dale's pharmacology, 8th edition from Humprey Rang.
3.Essentials of medical pharmacology(jaypee) k.d. Tripathi
4.Martinez-Vicente M, Talloczy Z, Kaushik S, Massey AC, Mazzulli J, Mosharov EV,
Hodara R, Fredenburg R, Wu DC, Follenzi A, Dauer W, Przedborski S,
I schiropoulos H, Lansbury PT, Sulzer D,Cuervo AM. Dopamine-modified
alpha-synuclein Blocks chaperone-mediated autophagy.
5.J Clin Invest. 2008;118:777–788.
6. Lotharius J, Brundin P. Impaired dopamine storage resulting from
alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease.
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