role of fructose in metabolic syndrome and renal …role of fructose in metabolic syndrome and renal...
TRANSCRIPT
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Role of Fructose in Metabolic Syndrome and Renal Disease
Richard J Johnson MDDivision of Nephrology, Hypertension and Transplantation
U of Colorado
Disclaimers:
Dr Johnson is an inventor on several patent applications related to the lowering of uric acid or the inhibition of fructose metabolism as a means to prevent and treat obesity related diseases
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Obesity: An Ever Expanding Problem
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Obesity: An Ever Expanding Problem
Johnson et al Am J Clin Nutr 86:899-906, 2007
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• Truncal obesity• Impaired fasting glucose (insulin resistance)• Elevated triglycerides• Low HDL cholesterol• Elevated blood pressure
• Other (Fatty Liver, elevated uric acid, microalbuminuria, elevated CRP, endothelial dysfunction, oxidative stress)
The Precursor to Diabetes: Metabolic Syndrome
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Incidence and Prevalence of Obesity and Diabetes in the U.S.
Ann Hum Biol 2004; 31: 174-81; Arch Int Med 1924; 34:585-630
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Sugar and Fructose
•Sugar (sucrose): a disaccharide of glucose and fructose
•High fructose corn syrup (HFCS): 55% fructose and 45% glucose as monosaccharides
•Fructose is also present in honey and fruit (especially fruit juices and dried fruits)
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A Potential Role for Sugar in the Obesity Epidemic?
Yudkin J. Proc Nutr Soc 1964; 23:149-162
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Year1700 1750 1800 1850 1900 1950 2000
Sug
ar C
onsu
mpt
ion
Kilo
gram
s/In
divi
dual
0
20
40
60
80
Obesity P
revalence %
0
10
20
30
40
50
60
Sugar Intake Correlates with Obesity
Sugar intake
Obesity rate
HFCS introduced
Johnson et al Am J Clin Nutr 86:899-906, 2007
Sugar intake per year
1700 4 lbs
1800 18 lbs
1900 90 lbs
2000 155 lbs
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Sugar Intake Correlates with Diabetes Rate
Johnson et al Endocrinol Reviews 2009
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Role of Fructose in Obesity
Ishimoto T, Jackman M, MacClean P, et al
*
Control Mouse
Fructose-fed Mouse
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50
90
130
170
Control Fructose
Systolic Blood pressure
mm
Hg
0200
600
1000
1400
Control Fructose
pg/m
l p<0.05
p<0.05
Serum Insulin
Fructose Induces Metabolic Syndrome in Rats
Nakagawa et al, Am J Physiol 2006; 290:F625-631
0
100
200
300
Control Fructose
mg/
dl
Triglycerides
p<0.05
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Fatty Liver Can be Induced by Sucrose Even with Caloric Restriction
Sprague Dawley rats fed sucrose or starch diet for 4 months at 90% of normal intake
Roncal C and Lanaspa MA submitted
Starch Fed Rat
Sugar Fed Rat
Oil Red O Stain for Fat
↑ FAT SYNTHESIS
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Fatty Liver Disease is Associated with Increased Soft drink Intake and Increased Fat Synthesis
Fructokinase mRNA in Liver Biopsy
Ouyang et alJ Hepatol 48:993. 2008 and Hugo Rosen and others
FAS
Control Fatty Liver
Fatty Acid Synthase*
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Baseline ChangeMetabolic Syndrome (NCEP-ATPIII)(%) 19% 44%
P Value Triglycerides 136 ± 15 55±20 <0.001HDL Cholesterol 46.5 ± 1.5 -2.5 ± 0.7 <0.001Insulin resistance (HOMA) 1.7 ± 0.2 0.57 ± 0.16 <0.005 Weight (kg) 84.3 ± 2.3 0.6 ± 0.2 <0.003BMI (kg/m2) 29.0 ± 0.6 0.2 ± 0.1 <0.00324 hr Systolic BP (mm Hg) 126±2 7 ± 2 <0.00124 hr Diastolic BP (mm Hg) 75 ± 2 5 ± 3 <0.001Uric acid (mg/dl) 5.2 ± 0.2 1.1 ± 0.8 <0.001
Effect of Fructose (200 g/d) for 2 weeks on Metabolic syndrome in Men: Menorca Study
Perez-Pozo et al Int J Obes 2010
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Fructose Induces Metabolic Syndrome in Animals
Johnson et al, End Rev 2009;30:96-116
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Fructose Metabolism
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Fructose Acutely Increases Serum Uric Acid
Lancet 1970; 2:1310-1311
Hours
Cha
nge
in U
ric
acid
(mg/
dl)
Fructose (1 g/kg body wt) increases serum uric acid within 30 minutes
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Soft Drink Consumption is Increasing
Nielsen and Popkin Am J Prev Med 2004; 27:205-210
Third National Health and Nutrition Exam Survey Choi et al Arth Rheum 2008; 59:109-16
Uri
c ac
id (m
g/dl
)
Soft Drinks/day
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Study (year) Population F/U Independent RR (C.I.)ARIC 9,020 adults 11 YRS Yes 1.3 (1.2-1.4) Spokane 60 adults with MI 6 MOS Yes 5.47 (1.6-17.7)Rotterdam 4,536 adults 10 YRS Yes 1.68 (1.22-1.30) Framingham 5,209 adults 26 YRS Men 2.3 (men) and 2.1 (women)Osaka 2,310 adult men 6 YRS Yes 1.78 (1.11-2.85) Osaka 6,356 men 9 YRS No 1.24 (0.9-1.7) Mauritius 2,605 adults 5 YRS Yes 1.37 (1.20-1.57) Britain 7,735 men 12.8 YRS Yes 1.5 (0.9-2.5)Sweden 766 men 13.5 YRS Yes 5.8 (2.2 - 16.0) Kinmen 641 adults 7 YRS Women 1.44 (1.13-2.25)Finland 522 adults 4.1 YRS Yes 1.87 (1.07-3.26)Mauritius 4259 adults 5 YRS Men 1.37 (1.11-1.68)Nauru 266 adults 6 YRS Women Not givenIsrael 10,000 men 5 YRS Yes 1.35 China 2609 adults 9 YRS Yes 1.4 (1.02-1.92)
Uric Acid Predicts Development of Hyperinsulinemia or Diabetes
Johnson et al, Endocrinol Rev 2009
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Acute Effects of Uric acid
Hypertension 2003; 41: 1287-93 Kidney Int 2005; 267: 1739-42 Am J Physiol 2002;282: F991-7, J Hypertens 2010; 28: 1234-42
Oxidants
Renin
Nitric Oxide
Uric Acid Control Inflammation (MCP-1)
Angiotensin II
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Fructose
↑Uric acid
Fructose, Uric acid, and Insulin Resistance
↓Nitric Oxide
Glucose
↑Insulin
↑Nitric Oxide
Skeletal muscle uptake of glucosepos neg
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Serum Uric acid
0
0.5
1
1.5
2
Control Fr Fr + AP
mg/
dl
P<0.05 P<0.01
Fructose induced Hypertension is Uric acid Dependent
Nakagawa et al, Am J Physiol 2006; 290:F625-631
100
110
120
130
140
150
160
0 4 8 WeeksSy
stol
ic B
P (m
mH
g) ControlFrFr + AP
##
*
Allopurinol
Blood Pressure
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Fasting insulin
0
500
1000
1500
2000
2500
control Fr Fr + AP
pg/m
l
P<0.01 P<0.05
Allopurinol Improves Insulin Resistance and Dyslipidemia in Fructose-fed Rats
Nakagawa et al, Am J Physiol 2006; 290:F625-631
0
100
200
300
Control Fr Fr + AP
mg/
dl
#
Triglyceride
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Allopurinol Prevents Obesity in Fructose-fed Rats
Body Weight (g)
340360380400420
control fructose FR+AP
Calorie Intake (Kcal/d)
8090
100110120130
control fructose FR+AP
* *p<0.05
Nakagawa et al, Am J Physiol 2006; 290:F625-631
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Uric acid Induces a Diabetic Phenotype in Adipocytes
Sautin et al, Am J Physiol Cell Physiol. 2007 Aug;293(2):C584-96
AdiponectinUric acid
Oxidized Lipids
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Allopurinol Reduces Leptin mRNA in Fat from Fructose Fed Rats
Lanaspa M et al Curr Rheum Rev in press
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Allopurinol Reduces Fat Inflammation in Mice with Metabolic Syndrome
Sautin et al, Diabetes 2011 in press
Lean Mouse
Obese Mouse
Obese Mouse + Allopurinol
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Sucrose Diet Induces Pancreatic Islet Injury
Roncal , Lanaspa, et al submitted
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Type 2 Diabetes induced by Sucrose
Roncal , Lanaspa, et al submitted
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The Uric acid Transporter URAT-1 is Increased in the Islets
Roncal , Lanaspa, et al submitted
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MCP-1 Induced in Pancreas of Sucrose Fed Fats
Roncal , Lanaspa, et al submitted
Whole Pancreas (PCR) Rat Insulinoma Cells
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The Evolution of Man
Proconsul, 18 MYADiscovered by Mary Leakey on Rusinga Island, Lake Victoria, in 1948
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Early Miocene Apes were Fruit Eating
Early Miocene Apes were Fruit
Eating and Lived in Lush Tropical Rain Forests in
Africa
(20-15 MYA)
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Fructose and Purines: Survival Factor(s)?
Fruit (fructose)Game (purines)
↑BP and ↑Salt sensitivity (Renal effects)↑Fat stores (fatty liver, triglycerides)↑Insulin resistance (↑glucose for to the brain)Leptin resistance (neural effects)
Starvation
Autumn
WinterSummer
Spring
Johnson RJ, J Comp Physiol B (2008)
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The Evolution of Man
Scientific American 1989;260:76-82
Uricase Mutation, 15.2 MYA
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Fructose: A Survival Factor
Fruit (fructose)Game (purines)
↑↑BP and ↑Salt sensitivity (Renal effects)↑↑ Fat stores (fatty liver, triglycerides)↑↑ Insulin resistance (↑glucose for the brain)↑↑ Leptin resistance (neural effects)
Starvation
Autumn
WinterSummer
Spring
Uricase Mutation
Johnson RJ, J Comp Physiol B (in press)
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New Guinea, 8000 Years Ago
Saccharum officinarum: The Noble Cane
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The Spread of Sugar Cane
6000 B.C.
500 B.C
500 A.D
600 A.D700 A.D
950 A.D1400 A.D
1500 A.D
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Sugar Plantations in Hispaniola
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The Triangle Trade
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Sugar: The Perfect Additive
1610-asia
1615-africa
1650-mexico
1550-barbados
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Sugar Intake Linked to Diabetes
Haven Emerson (1874-1957)
New York Health Commissioner and Director of Public Health at Columbia Arch Int Med 1924; 34:585-630
Diabetes increased from 2.8 cases/100,000 in 1880 to 19 cases per 100,000 in 1920
Risk FactorsWealthy
Over age 45
Sedentary
Men and postmenopausal women
Caucasian
Merchants in the Food Industry
Sugar consumption
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• Fructose rich diets (15-25%) raises blood pressure, triglycerides, and induces insulin resistance and weight gain in humans (i.e, can cause the metabolic syndrome)
• Metabolic Syndrome has a major role in driving hypertension, diabetes, and chronic kidney disease
Could Fructose be the Driving Force for the Epidemic of Cardiovascular Disease?
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The Economist, December 2003
The Evolution of Man
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Pietro Cirillo
Mike Gersch
John Kanellis
George Henderson
Takuji Ishimoto
Wataru Kitagawa
Yuri Sautin
Tomoki Kosugi
MyPhuong Le
Wei Mu
Xiaosen Ouyang
Karen Price
Sirirat Reungji
Carlos Roncal
Michiko Shimada
Mohamed Shafiu
Taka Nakayama
Katsuyuki Tanabe
Independent Collaborators
Jeffrey Thomas
Susumu Watanabe
Sergei Zharikov
Chris Rivard
Diana JalalGabriela Garcia Duk-Hee KangDan Feig Miguel Lanaspa
Marilda Mazzali Taka Nakagawa Gaby Sanchez-Lozada