roger oconnor soccgmpres 2016
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3 R O U N D T R E E D R I V E , M E R R I MA C K , N H O 3 O 5 4
6 0 3 -3 4 1 -8 4 0 5 O R G O H I L E @G MA I L .C O M
ROGER O ’ CONNOR
SYNTHETIC ORGANIC CHEMIST
Focused and very precise experienced research chemist with nearly ten years experience
designing and completing synthetic methodologies from retrosynthetic analysis to endgame
and spectroscopic analysis and structure determination of natural products, analogues and
polypeptides. Also experienced with coordinating off-site syntheses and written/electronic
reports and research progress communication and very experienced with 1D and 2D NMR, FTIR
and ATR, HPLC, recycling HPLC and GCMS/LCMS.
FUNCTIONAL SUMMARY
Development of synthetic strategies as well as nearly 10 years experience as bench chemist
Experienced with 1H, 13C, 19F, 31P, HH-COSY, CH-COSY, NOESY, HMQC and other
experiments and analysis and precise data processing.
Purification of various sythetic samples through recrystallization, chromatography and other
means if necessary due to noise and solvent impurites.
Able to coordinate synthetic strategies with goal oriented team leaders as well as like
minded coworkers.
Organized with written observations and laboratory notes for peer-reviewed publications
and data reporting as well as information retrieval and familiar with FDA GMP standards.
Have thousands of examples of prior research spectra for inspection and verification of all
referenced skill sets and am able to characterize many unknown molecular systems as well.
EMPLOYMENT
Associates of Cape Cod, Independent Contractor September 2009-September 2010
While contracting for ACC, I was responsible for the synthesis and spectroscopic analysis of
several polypeptides for the furtherance of research into detection systems derived from the
Limulus Horseshoe crab endotoxin and the resultant LAL clotting cascade. See
http://www.acciusa.com for further information.
Konarka Technologies, Independent Contractor January 2005-September 2005
A number of full and partial spectrum light absorbing conjugated hyphens were prepared using
a number of different catalytic methodologies, purified and characterized using various NMR
experiments as well as the standard spectroscopic means. This research was conducted
towards the development of innovative flexible organic dye-based photovoltaic cells and was
funded under numerous DARPA grants.
EDUCATION
Dartmouth College, PhD Candidate September 2005-July 2008
As a graduate researcher significant progress was made towards a novel total synthesis of the
naturally occurring anti-tumor compounds viridin and wortmannin. A number of significant
synthetic developments were achieved, most notably the development of a one-pot synthetic
methodology enabling a stereoselective synthesis of a model wortmannin compound This
included full NMR characterization using 1H, 13C, COSY, NOESY and HMQC techniques. Several
publications have been made based on this work over the last several years, in addition to
significant unpublished research.
University of Massachusetts Lowell BS, Chemistry September 2002-December 2004
As an undergraduate, research was conducted towards the development of a number of
antarafacial 2 + 2 ground state cycloadditions and further experimentation in attempts at
developing a ring opening/rearrangement cascade using metal hydrides as nucleophiles. While
these conditions proved viable only with highly strained ring systems it was a very instructive
lesson in the power of NMR technology in determining reaction products and structural analysis
as well as technical operation of the UNIX software and the instrumentation itself.
PUBLICATIONS
Constructing the Heterocyclic Core of Viridin and Wortmannin. Jacobi, P. A., Könekamp, T.,
Mascall, K.C., O’Connor, R.T., Onyango, E.O., Sessions, E.H.; Advances in Heterocyclic Chemistry
2013, 110(4), 119-143.
Mechanism of the decarboxylative rearrangement of β-(carbonyl)-
Cyclopropane carboxylic acids to 2-substituted-4,5-dihydrofurans.
Jahngen, E., Mallet, J., O’Connor, R.T., Jr., Fischer, S.; ARKIVOC 2007, 9,135-149.
Furanosteroid Studies. Stereoselective Synthesis of the A,B,E-Ring Core of Wortmannin.
Sessions, E.H., O’Connor, R.T., Jr., Jacobi, P.A.;Org. Lett. 2007, 9(17), 3221-3224. (Please see
supporting information for graphic representation of spectroscopic work).
REFERENCES
Edwin Jahngen
Professor of Chemistry
University of Massachusetts, Lowell
(603) 702-1389, (978) 934-3693,
Scott Selfridge
Research Chemist
Akita Innovations, LLC
(603) 321-1008
Savvas Hadjikyriacou
Chemist
Equova Water Technologies
(978) 649-0528
Peter Jacobi
Professor of Chemistry
Dartmouth College
(603) 646-3495