Robert H. WiltroutDirector, CCR

Director’s Address

DirectorRobert H. Wiltrout

Center for Cancer Research

Scientific Director for Clinical Science

Lee Helman

15 Clinical Branches

Deputy DirectorMark Udey

Scientific Director for Basic Science

Robert H. Wiltrout

38 Basic Science Laboratories and

Branches

Deputy DirectorsDouglas LowyJeff Strathern

Larry Samelson

Associate Director for Science

L. Michelle Bennett

Clinical Infrastructure

CCR Budget Relative to the NCI BudgetCCR Budget Relative to the NCI Budget

In 1995 the CCR budget was approximately 10% of the NCI budgetIn 2005 the CCR budget was approximately 7.7% of the NCI budget

NCI

0

500,000

1,000,000

1,500,000

2,000,000

2,500,000

3,000,000

3,500,000

4,000,000

4,500,000

5,000,000

1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006

CCR

CCR Budget Relative to the NCI BudgetCCR Budget Relative to the NCI Budget

In 1995 the CCR budget was approximately 10% of the NCI budgetIn 2005 the CCR budget was approximately 7.7% of the NCI budget

NCI

0

500,000

1,000,000

1,500,000

2,000,000

2,500,000

3,000,000

3,500,000

4,000,000

4,500,000

5,000,000

1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006

CCR

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NCI CCR

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Mission of the Center for Cancer Mission of the Center for Cancer Research, NCIResearch, NCI

Eliminate Death and Suffering from Cancer by:

- Integrating basic discovery with cutting edge technologies to create novel approaches for prevention and treatment of cancer

– Providing leadership and innovation in clinical trial development and performance

– Providing a distinctive venue for training the next generation of interdisciplinary basic and clinical researchers

– Establishing innovative partnerships with extramural organizations and private enterprise to accelerate the translation of new discoveries and technologies to clinical application.

Unique Identity of the NCI’s IRPUnique Identity of the NCI’s IRP

• Distinctive critical mass and unique programmatic integration of basic, clinical and epidemiologic scientists within a unified environment

• Review and reward structure that allows long-term, high-risk basic and clinical research

• Allows and encourages rapid changes in direction and response to new opportunities and national priorities

• Ability to fuse basic science with the newest technologies for novel clinical trials within the state of the art Clinical Research Center

• Ability to recruit diverse cohorts of patients to perform science-driven, concept-based clinical trials

• Distinctive and highly acclaimed interdisciplinary training programs for the next generation of biomedical scientists

• Mandate and freedom to collaborate widely and provide leadership for new basic and clinical research paradigms

• Higher stringency for avoidance of conflicts of interest than many other research institutions

Distinctive Qualities of CCRDistinctive Qualities of CCR

• Critical mass of basic and clinical scientists solving complex scientific problems

• Can quickly redeploy resources to address:(a) NCI mission goals

(b) Urgent public need

(c) New opportunities

• Access to NIH Clinical Center

The Center for Cancer Research:The Center for Cancer Research:A Comprehensive Translational Research ProgramA Comprehensive Translational Research Program

Molecular Targets and Molecular Oncology

Cancer Biology

and Etiology

Immunology, Immunotherapy, and Immunoprophylaxis

Genetics Genetics and and

GenomicsGenomicsHIV/AIDS HIV/AIDS ResearchResearch

Imaging and

Biomarkers

Advanced Biomedical

Technologies

Clinical Infrastructure and Support

CCR Infrastructure

Discovery Research

Clinical Research

Translational Research

HIV/AIDS Research

Training

Molecular Targets

Cancer Biology

Immunology

Genetics

HIV/AIDS

Imaging/Biomarkers

Advanced Technology

Clinical Infrastructure

CCR Infrastructure

CCR Major Theme AreasCCR Major Theme Areas

Training Faculty COE

Drug

Dev Imaging

Programs/

Initiatives Cores HIV/AIDS Epi

Molecular Targets

Cancer Biology

Immunology

Genetics

HIV/AIDS

Imaging/Biomarkers

Advanced Technology

Clinical Infrastructure

CCR Infrastructure

Infrastructure to Support Translational Multidisciplinary Research

Centers of Excellence: Focal Points for Centers of Excellence: Focal Points for Bench to Bedside TranslationBench to Bedside Translation

These Centers of Excellence serve to support the IRPs dedication to long-term, high-risk, innovative basic, clinical, and epidemiologic research.

Immunology

Chromosome Biology

Advanced Biomedical Technology

Molecular Epidemiology

Molecular Oncology

How Reengineering is Reshaping How Reengineering is Reshaping Interactions in the CCRInteractions in the CCR

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ReengineeringReengineering

andand

RedeploymentRedeployment

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- Outside of NCI+ - Other NCI entities

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Before After

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* - Basic Research

Mark O. Hatfield Clinical Research Center

Warren Grant Magnuson Clinical Center

NIH Clinical Center

The NCI Intramural Clinical The NCI Intramural Clinical Research ProgramResearch Program

• The NCI intramural clinical program is not a large volume, full-service cancer center

• The NCI intramural clinical program is the largest cancer-focused clinical research center (CRC) in the world, capable of performing patient-intensive clinical research focused on developing new approaches for prevention, diagnosis, and treatment of cancer.

• The NCI intramural clinical program is an important component of the nation’s overall cancer program

Clinical Molecular Profiling CoreClinical Molecular Profiling Core

All CCR Clinical ProtocolsAll CCR Clinical Protocols

Biospecimen Procurement and Processing FacilityBiospecimen Procurement and Processing FacilityLCM, AnnotationLCM, Annotation

Clinical Molecular Profiling CoreClinical Molecular Profiling Core

Genomic AnalysisGenomic Analysis-Array CGH-Array CGH

- Kinome - Kinome resequencingresequencing-SNP analysis-SNP analysis

- etc- etc

Tissue Tissue ProteomicsProteomics

DevelopmentDevelopmentExpression Expression ProfilingProfiling

Tissue ArrayTissue ArrayIHCIHCEtcEtc

Vision for the FutureVision for the Future

• Focus on testing new science-based hypotheses interrogating a disease or disease process

• Maximize our understanding of how to intervene in the disease process by interrogating the cancer network using genetic, proteomic, and imaging tools