rob scoffin, cresset, 'the cresset future
TRANSCRIPT
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The Future of Cresset?
Dr Robert ScoffinChief Executive Officer
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Customer Thanks
> You are the reason we are here> Our motivation is to create the best possible tools to aid
drug discovery
> Your input drives future developments
> Your financial support enables us to keep the lights on
> You are also the reason we will be here next year> Our ongoing commitment to maintaining the high quality of
our solutions
> Focus on innovation in both science and service
> Returning value for your investment in us
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2010-2011 Year In Review
> Cresset> Business grew 25% from 2009 to 2010
> Continued growth in 2011 – projecting > 35% 2010 to 2011
> Strong additions to the team – Mike, Rae, Viv, Janany, Chris, Martin, Rachel.
> Science> Extension of FieldAlign with 3D-QSAR methodology
> On-going development of new application for ‘Molecular Designers’
> Extended applications in peptide mimetics, drug re-profiling, etc.
> Portfolio Expansion> Extended Professional Services/Consulting offerings – driven by Martin
Slater, backed up by Chris Earnshaw, Andy, Rob, Tim & Mark
> Software-as-a-Service (SaaS) offering of FieldScreen (initially – others to follow)
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Diverse Cresset Users
• Cresset GUI applications provide simple access to Field-based science
• Focus on 2D chemistry and ‘task-oriented’ workflows
• Easy to use applications with consistent user interfaces
• Complete access to the underlying science through more comprehensive interfaces
• Focus on 3D chemistry and Field Points
• Able to generate results which can be shared with colleagues in Modelling and MedChem.
Medicinal Chemists Molecular Modellers
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Strategy for Growth
> Consolidate our position in existing markets> Strengthen current tools
> Look for other applications we can build on the existing science
> Further expand the science base of Cresset
> Develop New Markets> Med. Chem focus through new applications
> New users for existing technology: Patenting, In-Licencing, ADMET, etc.
> Expanded Services Offerings> Consulting services around use of the applications
> New delivery platforms for existing applications
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New delivery platforms
The latest addition to the Cresset team
The Cresset cow
> Cluster On Wheels
> Portable, on-demand computing infrastructure
> Pre-loaded FieldScreen application and database> Plug-in and go capacity expansion
> Secure – data on portable, removable drives
The Cresset COW
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Scientific Focus
> FF3> Free Dr Vinter up from mundane day-to-day activities to focus on completing
FF3
> Extensive validation and testing cycle – aim to release in 2012
> Re-Profiling/Re-Purposing> Extend applications in drug re-profiling
> TSB funded project with Biolauncher to build re-profiling database and toolkits
> Massively parallel computing> New initiative to re-code Cresset tools (initially FieldScreen, others to follow)
to run on GPU’s
> OpenCL implementation of the scoring functions
> Fields/Field points on proteins> Further investigation and application of Field approach to protein surfaces
and structures
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May the Force (field) be with you…
There’s a disturbance in the
Nitrogen force
When will FF3 be ready?
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Scientific Focus
> FF3> Free Dr Vinter up from mundane day-to-day activities to focus on completing
FF3
> Extensive validation and testing cycle – aim to release in 2012
> Re-Profiling/Re-Purposing> Extend applications in drug re-profiling
> TSB funded project with Biolauncher to build re-profiling database and toolkits
> Massively parallel computing> New initiative to re-code Cresset tools (initially FieldScreen, others to follow)
to run on GPU’s
> OpenCL implementation of the scoring functions
> Fields/Field points on proteins> Further investigation and application of Field approach to protein surfaces
and structures
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Ridley Scott’s Tribute to Andy
Andy Vinter
Batty: Nothing the God of biomechanics drug discovery wouldn't let you into heaven for.
Tyrell: The light that burns twice as bright burns for half as long - and you have burned so very, very brightly, Roy Andy. Look at you: you're the Prodigal Son; you're quite a prize!
Batty: I've done... questionable things.
Tyrell: Also extraordinary things; revel in your time.