road to the artificial pancreas (2015update) tlcbythesea
TRANSCRIPT
Road to theArtif icial Pancreas
Kevin L McMahontype 1 technology ventures, llcdiabetes technology consulting
The Problem● The average patient has difficulty keeping blood sugar
'between the lines' and avoiding extended duration of highblood sugar and severe low blood sugar
● Current technology for addressing these swings in bloodsugar require a lot of work and even then end up causingproblems of their own:
– Pump site failures
– Poor insulin absorption
– 12 to 20 minute blood sugar lags
– Missing / Inaccurate blood sugar data
Here's What They're Building
Inherent Problems● All AP Design Assumes A High Level of Effort
– Replace External Sensor > 50 x/yr
– Replace External Pump Site > 150 x/yr
– Up to 10% Failure Rate for Sensors & Pumps
The Open-Loop AP Is Already Here ●Insulin Delivery – Check!
● CGM – Check!
● Software/Firmware to Adjust Dosing re: BGs – Check!
● Training System to Teach AP Algorithms – Check!
Current Status● Machines are not smart – People are!
● Machines break; pump sites and sensors fail!
● Research grants for closed-loop have been discontinued.
● All currently supported real-world research programs:– subcutaneous hormone delivery
– subcutaneous glucose sensing
– limited approaches to dosing and safety algorithms
What's Missing?● Personalized Algorithms vs. One Size Fits All
● Level Playing Field for Innovation - “The AP Cartel”!
● Funding for “Star Trek” like Revolutionary Technology
● Patient Access to Open-Loop Education Programs
Open-Loop AP Algorithm
MotivationYour Brain
Sugar SurfingTM
+ Well-Calibrated CGMOpen-Loop Artificial Pancreas
Thank You!
Kevin L McMahondiabetes technology inventorresearch investigator / industry consultant
type 1 technology ventures, [email protected]://type1techventures.com