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RHEOLASER LAB MICRORHEOLOGY & END USE PROPERTIES ANALYSIS www.formulaction.com MICRORHEOLOGY

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  • RHEOLASER LABMICRORHEOLOGY &

    END USE PROPERTIES ANALYSIS

    www.formulaction.comMICRORHEOLOGY

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  • A NEW RHEOLOGY APPROACH TO CHARACTERISE END-USE PROPERTIES

    BENEFITS OF MICRORHEOLOGY

    Rheolaser Lab is the first ready-to-useinstrument to perform micro-rhe-ology experiments.Microrheology is a new domain of Rheology, which characterises the structure of the material at the micron scale.

    Visco-elastic properties of soft materi-als such as emulsions, gels, polymers etc… are analysed by measuring the displacement of the particles in the material due to the thermal energy (Brownian motion).

    Rheolaser™ is the first ready-to-use instrument to perform microrheology experiments.

    NON CONTACT MEASUREMENT Measurement is performed without any external stress (thus always in the linear visco-elastic regime). It allows the analysis of fragile materials (weak gels, creams…) without sample modification nor destruc-tion.

    VISCOELASTIC PROPERTIESVS. TIMEMeasurement is performed in a glass cell:• Structure recovery• Gelation process• Long-term stability• ...

    EASY SAMPLE HANDLINGMeasurement is performed in a glass cell:• No sample deformation or destruction• No evaporation or drying• No geometry configuration• Disposable measurement cell

    The software has been designed for both experts and non experts in rheology with automated one-click results or fully configurable parameters.

    • Mean Square Displacement (MSD)

    • Solid-Liquid Balance (SLB)

    • Elasticity Index (EI)

    • Macroscopic Viscosity Index (MVI)

    • Elastic & Viscous Moduli (G’, G’’)

    • Physical parameters ( tR , Dm, η )

    MULTI DATA ANALYSIS

    Rheolaser™ has 1 to 6 measuring posi-tions. The optical detection system uses Multi-Speckle Diffusing Wave Spectros-copy (MS-DWS). It measures interfering backscattering waves resulting from laser light multi-scattered by the particles. This accurate technique enables detection of small particle displacements. Particle mean square displacement data enables access to the microrheology parameters.

    THE OPTICAL MICRO-RHEOMETER: The measurement provides a viscoelastic signature

    of the product which is the MSD & 3 automatic parameters to quantify its end-use properties.

    KEY PARAMETERS IN 1-CLICK

    MEAN SQUARE DISPLACEMENT (MSD)

    • Visual signature of the product’s viscoelasticity.

    => Compare qualitatively various products in a blink.

    • Characterization at rest

    • Evolution (gelation, melting...)

    • Structure recovery & thixotropy

    • Stability (vs. ageing time)

    THE FIRST READY TO USEMICRORHEOLOGY& END-USE PROPERTIES

    ANALYSER

    The easy sample handling and automatic data processing enables different types of experiments to be carried out.

    MULTI APPLICATIONS SOLID-LIQUID BALANCE (SLB)• Ratio between the solid-like and the liquid-like behaviour of

    the studied materials.

    => Monitor properties such as : adhesion, spreadability, gel point, shape stability, physical stability, etc...

    ELASTICITY INDEX (EI)

    • Elasticity strength in the studied materials.

    => Monitor properties such as : mesh/pore size, hardness, recovery after a shear, gelation...

    MACROSCOPIC VISCOSITY INDEX (MVI)

    • Quantify and compare the macroscopic viscosity at zero-shear.

    => Monitor properties such as : effect of a thickening agent, texture, flowability, physical stability, etc...

    RECOVERY SHAPE STABILITY DRUG DELIVERY TEXTURE STABILITY GELATION

    STABLE

    UNSTABLE

    LIQUID

    SOLID

    VISCOSITY

    ELASTICITY

  • www.formulaction.com

    10, impasse Borde Basse31240 L’Union - France

    +33 (0)5 62 89 29 29

    MICRORHEOLOGY : A NEW WAY OF INVESTIGATING SOFT MATERIALS

    «Microrheology looks at the thermal motion of small particles embedded in a material in order to extract its bulk rheological properties. This experimental technique opens the investigation of material properties that are difficult to access or inaccessible by conventional rheology such as the visco-elastic response of fragile materials.It is a non-intrusive technique, and thus particularly well suited to study fragile materials such as weak gels (emulsions, yoghurts, cosmetics, …). No macroscopic stress is applied to the sample which avoids its destruction or its modification. This techniques increases our understanding of these materials.”

    Annie ColinRheologist ProfessorUniversity of Bordeaux IInstitut Universitaire de France

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    Emission

    DetectionCell Volume

    Storage positionsSimultaneous measurements

    Temperature rangel* measurement

    Minimum Viscosity (mPa.s)

    Dimensions (cm)Weight (kg)

    Minimum PC configuration

    Recommended PC configuration

    SPECIFICATIONS RHEOLASER LAB RHEOLASER LAB6 RHEOLASER LAB6+ Light source Light source Light source 650nm 650nm 650nm MS-DWS MS-DWS MS-DWS 4 or 20ml 4 or 20ml 4 or 20ml 6 6 6 1 6 6 RT +5°C to 60°C RT +5°C to 60°C RT +5°C to 90°C No No Yes 500 500 30

    60x40x30 36

    Intel P4 @2Ghz or AMD 6000+ Processor 1 Gb Ram - Microsoft Windows XP

    Intel Dual Core @2.5Ghz or AMD X2 Processor 4 Gb Ram - Microsoft Windows XP, or 7, 32 bits

    APPLICATION FIELDS

    Paint & Ink

    Polymers...

    Cosmetic

    Food

    Pharmaceutical

  • www.formulaction.comMICRORHEOLOGY

    DIFFUSING WAVESPECTROSCOPY OPTICAL MEASUREMENT OF PARTICLES MOBILITY

    What is DWS ?Diffusing Wave Spectroscopy is the dynamic Multiple Light Scat-tering measurement which tracks particle motion in a fluid.DWS is the Dynamic Light Scat-tering extended to opaque and concentrated media.

    MS-DWS* Principle of MeasurementMS-DWS consists in sending a co-herent laser light beam into a sam-ple. The light is multi-scattered by the particles, which leads to in-terfering backscattered waves. An interference image called “Speckle image” is detected by a multi-pixel detector.

    In a soft material, the thermal energy kBT leads to the motion of micron sized particles .

    This Brownian motion induces a deformation of the speckle image.

    The multi-pixel detector measures the speckle pattern deformation to quantify motion speed of the particle .

    BENEFITSOF MS-DWS

    • Works on opaque and concentrated media

    • Sensitive to small particle displacement (from 0,1 to 1000 nm)

    • Access to microrheology parameters : - Viscosity - Elasticity - Relaxation time…

    * Multi Speckle Diffusing Wave Spectroscopy

    INTERFERING WAVES

    LIGHT SOURCE

    LASER

    SCATTERING

    MULTI-PIXEL DETECTOR

    SPECKLE IMAGE

    EXPERIMENT SET UP

    PRINCIPLE OF MEASUREMENT

  • www.formulaction.comMICRORHEOLOGY10, impasse Borde Basse31240 L’Union - France+33 (0)5 62 89 29 29

    Multi-speckle Diffusing Wave Spectroscopy microrheology (MS-DWS µRheology) is a recently introduced technique that greatly simplifies rheological measurements. No macroscopic deformation is applied to the sample. Instead, state-of-the-art optical techniques are used to measure the nanometer-scale motion of the sample con-stituents due to thermal energy. Rheological properties are deduced from this motion using a well-established formalism. Advantages of MS-DWS µRheology include:

    • measurements in the linear regime• no wall slip issues• samples contained in standard vials • no need to transfer the sample nor to clean the rheometer tools• fast measurements that allow the sample evolution to be monitored

    MS-DWS PROCESSING

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    MS-DWS

    APPLICATIONSMS-DWS is a powerful multiple light scattering method to measure particle mobility.This technology is useful to analyse opaque and concentrated materials like concentrated emulsions, gels, polymers…

    MS-DWS is used by:

    • Rheolaser LAB to analyse the microrheology of soft materials

    • Rheolaser Horus to characterise film forming products (coatings, varnishes, cosmetic films…)

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    PARTICLE MEAN SQUARE DISPLACEMENT (MSD)

    SLB, EI, MVI

    MICRORHEOLOGY

    PATENTEDALGORITHM

    PATENTEDALGORITHM

    +CORRELATION

    FONCTION

    SPECKLE IMAGE

    GENERALISED STOKESEINSTEIN RELATION

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    = Shear modulus

    = Thermal energy

    = Particle radius= Laplace frequency= Laplace transform of MSD

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    = Elastic modulus

    = Viscous modulus

    MS-DWS AND MICRORHEOLOGY

    Luca Cipelletti ProfessorUniversité de MontpellierInstitut Universitaire de France

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