Revolutionizing Allergy Treatment

Current Trend in the Treatment

&Management of Allergic

Rhinitis

2

Allergy Suffers in Canada

3 M

1.9 M0.4 M

3 M

2.9 M

Grass Ragweed Dust, Mite Cat Birch

3

Relative Prevalence of Allergen (%)

60

18

12

5

3

2

0 10 20 30 40 50 60 70

Pollen

Mites

Epithelia

Insects

Foodstuffs

Drugs

Sources: identified in allergic patients

4

Seasonal or Perennial Allergies

43%

56%

1%

Seasonal Perennial Not Sure

Allergies in America Exe. Summary; Aug. 23, 2007.

5

Allergic rhinitis is one of the most common diseases

About ten million Canadians suffer from seasonal allergies or seasonal allergic rhinitis

Fall is the worst time of the year. Shorter days and longer nights that start in mid-August stimulate pollination in the ragweed plant

Seasonal and perennial rhinitis affects 4 to 40% of the population and is increasing

Prevalence in 16-year-old children rose from 12 % to 23 % from 1958 to 1970

Allergic Rhinitis Affects many Canadian Allergic Rhinitis Affects many Canadian Adults and ChildrenAdults and Children

6

Quality Of Life

More than 62 percent of sufferers say allergies

significantly impact their day-to-day lives, including

affecting sleep patterns and ability to perform at work.

Residents of Manitoba / Saskatchewan are affected the

most (69%), followed by Ontarians (66%), then

Quebecers (60%).

7

Males Vs Female

67

55

0

10

20

30

40

50

60

70

Female Male

Females are impacted more severely

%

Allergy Season in CanadaAllergy Season in Canada

Province JanJan FebFeb MarMar AprilApril MayMay JuneJune JulyJuly AugAug Sept.Sept. OctOct NovNov DeDecc

BC

Prairies

Ontario

Quebec

Atlantic

All Prov. Molds Animal dander/ saliva House Dust Mite Cockroach

Grass Tree Ragweed Weed

9

Visit to the Health Care Practitioners

47

32

47

55 57

0

10

20

30

40

50

60

All Patients No Symptoms MildSymptoms

ModerateSymptoms

SevereSymptoms

N = 2500

Allergies in America Exe. Summary; Aug. 23, 2007.

Alle

rgy S

uff

ere

rs%

10

AR a Major Contributor to Health related Absenteeism

0 100 200 300 400 500 600

Allergic Rhinitis/ Hay Fever

Stress

Migraine

Depression

Arthritis/ Rheumatism

Anxiety Disorder

Respiratory Infection

Hypertension or High BP

Diabetes

Asthma

Coronary Heart Disease

Mean Annual Productivity Loss ($) Per Employee

*P<0.05 for Allergic rhinitis /hay fever vs. other conditions.Lamb CE, et al. Curr Med Res Opin. 2006; 22:1203-1210.

11

AR Imposes a Significant Burden on Quality of Life

AR is Associated With:

Fatigue and daytime sleepiness Daily activity impairmentReduced work productivity Impaired cognitive functioningReduced learning abilitiesImpaired sleepImpaired quality of life

Marshall PS, et al. Psychosom Med. 2002;64:684-69; Stuck BA, et al. J Allergy Clin Immunol.2004;113:663-668; ousquet J, et al. J Allergy Clin Immunol. 2006;117:158-162; Tanner LA, et al.Am J Manag Care. 1999;5(suppl 4):S235-S247; Blanc PD, et al. J Clin Epidemiol. 2001;54:610-618; Wilken JA, et al. Ann allergy Asthma Immunol. 2002;89:372-380; Marshal PS, et al. Ann Allergy Asthma Immunol. 2000;84:403-410; Vuurman EFPM, et al. Ann Alllergy. 1993;71:121-126;Leger D, et al. Arch Intern Med. 2006;166:1744-1748.

12

Use of OTC Medications

53

45

36

22

69

31

0

10

20

30

40

50

60

70

OTC Any Rx Rx NasalSpray

Other Rx Any Rx orOTC

Medication

NoMedication

AR

Su

ffere

rs W

ho U

sed

M

ed

icati

on

s in

Past

4 W

eeks

Allergies in America Exe. Summary; Aug. 31, 2007.

%

1313

Impact of Family History on Diagnosis of AR

No Family History

One Parent With AR

Both Parents With AR

57/334

(17.1%)

11/21

(52.4%)

31/120

(25.8%)

Total, N = 816

No Allergic diseases, n=449 (some children had more than one allergic disease)

Rhinitis, n = 99

Gerrard JW, et al. Ann Allergy. 1976;36:10-15.