Revolutionary Laminar Flow TechnologyIn Triple Quadrupole Mass Spectrometry

SENSITIVITY

Low femtogram level detection. Effi-cient laminar flow interface (HSIDTM Ultra), laminar flow ion guides, and five-stage pumping direct ions into the mass spectrometer at any given flow rate with minimum losses.

EASE OF USE

“Go with the flow” provides optimum performance with minimal optimiza-tion and tuning. Carried by gas flow, ion tuning is quick and accurate.

RUGGEDNESS

Minimal susceptibility to system instabilities, and greatly improved signal stability and reproducibility, by reducing any line of sight con-tamination.

TORRENTTM COAXIAL FLOW ION SOUCE

Proprietary geometry provides efficient desolvation, vaporization and ion entrainment for a high yield of ion production and trans-fer for ESI and APCI.

Creating a New Horizon in Design

and Engineering for LC/MS/MS

Revolutionary System ArchitectureIn Triple Quadrupole Mass Spectrometry

SMALL FOOTPRINT

Innovative vertical orientation with base of 50x50 cm increases your useful lab space.

SYSTEM RELIABILITY

A common interconnect backplane minimizes connectors and cabling by more than 80%, increasing system robustness.

EASE OF SERVICE

Full system modularity provides component by component plug and play, including the FlowTuneTM Ion Path, dramatically improving serviceability, reducing service downtime and cost.

Revolutionary SyIn Triple Qu

SMALL FO

Innovative vertwith base of 50your useful lab

SYSTEM R

A common inteminimizes connby more than 8system robustn

EASE OF S

Full system mocomponent by and play, includIon Path, dramserviceability, rdowntime and

Data Acquisition and Processing Software State of the Art Quantitation

Developed for IONICS by Phenomenome Dis-coveries of Saskatoon, Canada, MolAna is a complete data acquisition and quantitation pack-age that is designed to work in today’s multi-instrument, multi-vendor laboratory environ-ments.

Easy to use and intuitive, MolAna has a user-friendly, workflow oriented interface and simple method setup. MolAna provides efficient quantita-tion, with fast and reliable curve fitting and integra-tion; has import/export capabilities; and many other advanced and automated features for efficient data processing.

Designed for chromatographers, MolAna provides full data acquisition capability, including multiple overlapping experiments within the same method.

MolAna introduces the universal quantitation package that enables users to extract and perform quantitation for data collected in virtually any analysis mode.

Multiple overlapping experiment method editorManual Tuning preview window

Quantitation method creation Standard calibration curve

er-mpletita-gra-any for

tionand ally

Acetaminophen, a commonlyused analgesic (pain reliever)and antipyretic (fever reducer)was analyzed. It is a challenging compound to run by mass spec-trometry as a result of its lowmolecular weight (151) andfragility. It was run in the positive ion mode by electrospray usingMRM mode monitoring of152/110.

The HPLC separation was accomplished at the flow rate of 200ul/min by employing25/37.5/37.5 water/acetonitrile/methanol with 0.1% formic acid using a Beta Basic C18 2.1 X 50 mm 3micron column injecting 5ul. The signal to noise, based on 3 sigma, was 36/1 on the 50 fg/ul injection. The concentration range run shows excellent linearity.

The transition 609 to195 wasmonitored using MRM. Thesignal to noise is better then90:1. Here a 5 microliter injec-tion volume is used. The chro-matographic conditions were3/7 water/Acetonitrile 2mMammonium acetate with 0.1%formic acid at a flow of 0.2milliliter per minute.

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ION SOURCE

ION SOURCE TYPE

FLOW RATES

SOFTWARE

DIMENSIONS

WARRANTY

TorrentTM Single or Dual Probe

ESI/APCI

5 uL/min 3 mL/min

MolAna 1.0 software

50 cm L, 50 cm W, 110 cm H

3 Years

SENSITIVITY

SCAN SPEED

MRM SPEED

MASS RANGE

DYNAMIC RANGE

POLARITY SWITCHING SPEED

DETECTOR

Low femtogram levels

5000 Da/s

<5ms dwell time/pause time

5-1500 m/z

5 orders of magnitude

Ion formation dependent

UniFieldTM high dynamic range

ultrafast detection

SPECIFICATIONS

Research use only. Information, descriptions and specifications in this publication are subject to change without notice.

IONICS Mass Spectrometry Group shall not be liable for errors contained herein or for incidental or consequential damages in connection with the furnishing, performance or use of this material.

*IONICS 3Q Molecular Analyzer , MolAna Software, Torrent Ion Source, FlowTune Ion Path, HSID Ultra and UniField Ion Detector are the trade marks of IONICS Mass Spectrometry

Group, Inc.

IONICS Mass Spectrometry Group, Inc.1-32 Nixon Road, Bolton , ON L7E 1W2 , Canada; 905-857-5665 x 226; Fax 905-857-3040; info@ionics.ca; www.ionics.ca

Ionics MSE Eastern US, 14408 Kings Grant, Gaithersburg , MD 20878 , USA ; Phone: 301-461-0259; Fax: 240-328-6858; gg@ionicsmse.com; www.ionicsmse.com

Ionics MSW Western US, 7329 Gabbiano Lane, Carlsbad , CA 92011 , USA ; Phone: 760-815-9611; bahramd@ionics.ca; www.ionics.ca

Ionics MSV Europe, Antennestraat 14, 1322 AB Almere, The Netherlands; Phone: +31 36 5468 755; Fax: +31 36 5468 756; info@ionicsmsv.eu; www.ionicsmsv.eu

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