reviewers, volume 8 (1994)genesdev.cshlp.org/content/8/24/local/back-matter.pdf · reviewers,...

Reviewers, Volume 8" (1994) The Editors would like to thank the Editorial Board and the following scientists who were kind enough to review papers and provide advice during 1994. Your help has been invaluable and is greatly appreciated.

*From November 16, 1993 to October 16, 1994.

Abelson, John Adams, Tom Adler, Paul Allshire, Robin Allwine, Jim /kit, Fred Altman, Sid Alwine, James Arndt, Kim Augenlicht, Leonard Avery, Leon Baker, Bruce Baker, Tania Baldwin, Albert Balmain, Alan Baltimore, David Banerjee, Utpal Barbacid, Mariano Bargmann, Cori Barlow, Denise Bass, Brenda Bate, Michael Bautch, Vicki Beach, David Beato, Miguel Beckendorf, Steve Beddington, Rosa Beggs, Jean Belasco, Joel Bell, Steve Benchimol, Sam Berk, Arnie Bernards, Rene Berns, Anton Bickmore, Wendy Bingham, Paul Bird, Adrian Bishop, J. Michael Blackburn, Elizabeth Blau, Helen Bohmann, Dirk Bolen, Joe Borst, Piet Botchan, Mike Bouck, Noel Bradley, Allan Breeden, Linda Broach, James Brow, David Brown, Pat Bryant, Peter Buckingham, Margaret

Bulido, D. Buratowski, Steve Burley, Steve Burtis, Ken Busslinger, Meinrad Butcher, Eugene Capecchi, Mario Carey, Michael Cedar, Howard Cepko, Connie Chaconas, George Chamberlin, Michael Chandler, Vicki Chater, Keith Chesebro, Bruce Clarke, Louise Clayton, David Cline, Thomas Cohen, Stanley Cole, Chuck Cooke, Howard Cooley, Lynne Corey, Suzanne Costantini, Frank Courey, A1 Crabtree, Gerald Craig, Betty Cross, Fred Cullen, Bryan Curran, Tom Darnell, Jim Davidson, Duncan Davies, Kay Davis, Ron de Lange, Titia DePamphilis, Mel Desiderio, Stephen Desplan, Claude Devreotes, Peter Dexter, T. Mike Diffley, John DiNardo, Steve Doe, Chris Donahue, Tom Draetta, Giulio Dreyfuss, Gideon Drubin, David Dubolis, Ray Dworkin, Martin Dynan, Bill Ecker, Joe Edlund, Thomas Efstratiatis, Argiris Eichele, Greg Eisenmann, Robert Elledge, Steve Ely, Bert Emerson, Beverly Emerson, Charles Engel, Doug Evan, Gerard Evans, Ron Fangman, Walt Farr, Christine

Fearon, Eric Federoff, Nina Felsenfeld, Gary Fields, Stan Finley, David Firtel, Rick Flavell, Dick Folkman, Judah Freedman, Len Friedberg, Errol Fuchs, Elaine Ganem, Don Gasser, Susan Gaynor, Richard Gill, R.E. Gilman, Mike Glass, Chris Glover, David Sober, Jim Goodfellow, Peter Goodman, Corey Gottesfeld, Joel Gottesman, Susan Gottschling, Dan Stalls, Jay Graves, Barbara Green, Michael Greenberg, Michael Greenwald, Iva Gridley, Tom Grieder, Carol Griep, Anne Griffith, Jack Grossman, Alan Grunstein, Michael Gruss, Peter Guthrie, Chris Gutmann, David Haber, Dan Haber, Jim Hafen, Ernst Hahn, Steven Hammer, Robert Hanahan, Douglas Harrison, Steve Hartwell, Leland Hawley, Scott Hearing, Patrick Heath, John Hecht, Norman Helfman, David Henikoff, Steve Hernandez, Nouria Herrick, Glenn Herskowitz, Ira Hieter, Phil Hill, Bob Hinnebusch, Allan Hochstrasse, Mark Hoeijmakers, Jan Hoffman, Michael Hogan, Brigid Hopkins, Nancy Horz, Wolfram

3080 GENES & DEVELOPMENT

Howley, Peter Hughes, David Hughes, Steve Hunter, Tony Jacks, Tyler Jackson, Ian Jackson, Richard Jackson, Steve Jacobson, Alan Jaeckle, Herbert Jaenisch, Rudi Jan, Yuh-Nung Jenkins, Nancy Johnson, Peter Johnston, Lee Jones, Katherine Joyner, Alex Kadesch, Tom Kahmann, Regine Kaiser, Chris Karin, Michael Karpen, Gary Kassavetis, George Kastan, Michael Kaufman, Paul Kay, Rob Keene, Jack Keller, Gordon Keller, Walter Keroppola, Tom Kerr, Ian Kim, Stuart Kimelman, David Kimmel, Alan Kingsley, David Kingston, Robert Kintner, Chris Kipling, David Kleckner, Nancy Klobutcher, Larry Kolodner, Richard Konarska, Maria Korsmeyer, Stanley Krainer, Adrian Krisch, Henry Krumlauf, Robb Kustu, Sydney Lambowitz, Alan Lane, David Lassar, Andrew Lehman, Ruth Lengyel, Judith Leong, Sally Levin, Dan Levin, David Levine, Arnold Lichten, Michael Lin, Jim Lis, John Little, John Lowy, Doug Luhrman, Ruth Lund, Elsebet Lundblad, Vicki Luse, Don Lustig, Art

MacDonald, Paul MacDonald, Raymond Malloy, Dan Maniatis, Tom Mann, Richard Marshall, Chris Martienssen, Rob Mattai, Ian Mayfield, Steve McCormell, Sue McKeown, Mike McMacken, Roger McStay, Brian Melchers, Fritz Meyerowitz, Elliott Mitchell, Pamela Mizuuchi, Kiyoshi Modolell, Juan Moon, Randy Moore, Claire Moran, Betty Morimoto, Rich Morin, Gregg Morris, John Mount, Steve Munger, Karl Murray, Andrew Murre, Cornelius Nasmyth, Kim Neiman, Paul Ness, Scott Nevins, Joe Newlon, Carol Nilsen, Tim Noller, Harry Nomura, Masayasu Olson, Eric Oren, Moshe Orkin, Stuart Orr-Weaver, Terry Oshima, Robert Pabo, Carl Papaioannou, Ginny Pape, Louise Paro, Renato Parslow, Tristan Pavletich, Nicolas Perlman, Phil Perlmutter, Roger Perrimon, Norbert Peterson, Craig Petes, Tom Posakony, Jim Powers, Scott Pugh, Frank Quail, Peter Radding, Charles Raft, Martin Rastan, Sohaila Reed, Steve Reeder, Ron Reinberg, Danny Rice, Andy Richter, Joel Rigby, Peter Riggs, Arthur

Rine, Jasper Rio, Don Roberts, Jeff Roberts, Jim Robertson, Liz Rochaix, Jean-David Rosbash, Michael Rosen, Craig Rosenberg, Naomi Rosenfeld, Geoff Rossant, Janet Roth, John Rothstein, Rodney Rutter, William Ruvkun, Gary Sachs, Alan Samuel, Charles Sassone-Corsi, Paolo Schaffner, Walter Scharff, Matt Schedl, Paul Schedl, Tim Schlief, Robert Schupbach, Trudi Schwarz-Sommer,

Zsuzsanna Semler, Bert Shapiro, Lucy Sharp, Phil Shekman, Randy Sherr, Charles Sherratt, David Shimkets, L. Shore, David Silver, Lee Simons, Robert Simpson, Robert Skalka, Anna Smale, Steve Smith, Jim Sollner-Webb, Barbara Sonnenberg, Nahum Sorger, Peter Spector, David Spiegelman, Bruce Spradling, Allan Sprague, George Stark, George Starlinger, Peter Stellar, Herman Stenlund, Arne Sternberg, Paul Stewart, Colin Stiles, Chuck Storb, Ursula Stragier, Patrick Strathern, Jeffrey Strickland, Sid Struhl, Gary Struhl, Kevin Stunnenberg, Henk Summers, Jesse Surani, Azim Susskind, Mimi Takeichi, Masatoshi Tegtmeyer, Peter

GENES & DEVELOPMENT 3081

Theurkauf, William Thompson, Craig Thummel, Carl Timberlake, Bill Tlsty, Thea Toda, Takashi Tomlinson, Andrew Tonks, Nick Trainor, C. Treisman, Richard Van Montagu, Marc Vermstrom, Bjorn Verma, Inder Wahl, Geoffrey Wasserman, Steve Weber, Klaus Weinberg, Robert Weintraub, Harold Wessler, Sue West, Stephen Weston, Kathleen White, Eileen Wickens, Marvin Wickner, Sue Wieschaus, Eric Wildeman, Alan Willard, Hunt Williams, Jeff Williams, Trevor Windle, Brad Winston, Fred Wise, Joanne Witte, Owen Wolffe, Alan Wormington, Michael Woychik, Rich Wright, Chris Yaffe, Michael Yamamoto, Keith Yamamoto, Masayuki Yanofsky, Charles Yanofsky, Marty Young, Rick Yudkin, Michael Zakian, Virginia Ziff, Ed


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Author Index, Volume 8 Abbud, R., 2302 Abovich, N., 843 Ackerman, L.D., 2123 Adams, T.H., 641 Albalat, R., 2513 Albert, D.M., 1300, 1738 Alifano, P., 3021 Allen, J.B., 2401 Allerson, C.R., 3008 Alt, F.W., 1043 Altschmied, L., 339 Aiwine, J.C., 576 Amanuma, H., 45 Andachi, Y., 1935 Andreeva, A., 2928 Andr6s, V., 245 Ansieau, S., 2781 Anton-Lamprecht, I., 2574 Aparicio, O.M., 1133 Ardman, B., 1043 Arnaud, M., 970 Arnheiter, H., 2770 Arora, K., 2588 Arraiano, C.M., 3021 Auble, D.T., 1920 Auerbach, A., 1897 Autexier, C., 563 Avigan, M., 465 Baccarini, M,, 1803 Bachhawat, A.K., 1379 Bachvarova, R.F., 2466 Badiani, P., 770 Baeza, L., 2928 Bailey, A.M., 2729 Bailly, V., 811 Baker, T.A., 2416 Baltimore, D., 783, 1030 Bang, A.G., 2058 Banuett, F., 1367 Barak, Y., 1739 Bardwell, V.J., 1664 Barettino, D., 3068 Baribault, H., 2964 Barnes, J.P., 1473 Baron, C., 376 Barone, M.V., 453 Barrett, K., 2805 Bartelmez, S., 2831 Barton, M.C., 2453 Bazar, L., 465 Beach, D., 1750 Beall, B., 234 Beijersbergen, R.L., 2680 Belair, C., 2227 Belfort, M., 1575 Bell, L.R., 2072 Benedyk, M.J., 105 Berk, A.J., 190, 995 Bernards, R., 2680 Berns, A., 757 Betsholtz, C., 1875 Bhatt, H., 2953 Bier, E., 2602 Biggin, M.D., 1678

Bilger, A., 1106 Binari, R., 300 Bindley, C., 2227 Bird, A.P., 2282 Birkenmeier, E.H., 1853 Blackburn, E.H., 84 Blackwell, T.K., 1043 Blendy, J.A., 981 B6ck, A., 376 Boeke, J.D., 2046 Bolden, A.H., 2324 Bone, J.R., 96 Bopp, D., 598 Bouvet, P., 1147 Bowler, C., 2188 Bowman, M., 720 Bradley, A., 2008 Brand, A.H., 629 Brannan, C.I., 1019, 2792 Breitman, M.L., 1897 Brewer, B.J., 554 Brill, J.A., 1759 Bronson, R.T., 277 Brophy, B., 2879 Brou, C., 2491 Brow, D.A., 221 Brown, M.S., 1910 Bruhn, L., 2691 Bruni, C.B., 3021 Buchberg, A.M., 1019, 2792 Budavari, A.I., 1224 Buettner, R., 1258 Bultman, S.J., 481, 1463 Burns, N., 1087 Biischer, D., 1803 Butler, S., 2629 Cadigan, K.M., 899 Cai, J., 2022 Campbell, A.M., 2868 Capecchi, M.R., 1949 Cardiff, R.D., 23 Carl6e, L., 2680 Carlomagno, M.S., 3021 Carrasco, C.D., 74 Caudy, M., 2743 Cech, T.R., 1198, 1984 Chait, B., 3058 Chambers, A.E., 1324 Champion-Arnaud, P., 1974 Chan, Y.-m., 2574 Chang, J.S., 598 Charlton, J., 2282 Cheatham, L.A., 1212 Chen, G.-F.T., 2641 Chen, J., 1235 Chen, J., 1356 Chen, J.-L., 2313 Chen, S., 3008 Chen, W.S., 2466 Chen, Y.-Y., 678, 688 Chen, Z., 2293 Chiao, P.J., 1258 Chiara, M.D., 245 Chien, K.R., 1007

Chittenden, T., 2665 Cho, K.R., 1174 Choi, E.-Y., 1087 Chory, J., 339 Christerson, L.B., 614 Chua, N.-H., 2188 Clark, A.M., 948 Clarkin, K., 2540 Clayton, D.E., 2617 Coetzee, T., 1575 Coffin, J.M., 1473 Collart, M.A., 525 Collins, S., 2831 Coodly, L., 2257 Cooper, C.M., 959 Cooper, J.P., 1400 Copeland, N.G., 265, 399,

1019, 1613, 2770, 2792 Corbella, P., 770 Corces, V.G., 2046 Corcoran, L.M., 1030 Cormack, B.P., 1335 Cox, L.A., 2008 Cozzarelli, N.R., 1356 Cross, F.R., 1058 Crozat, A., 453 Crozatier, M., 2718 Da Costa, M., 959 Darnell Jr., J.E., 2466 Darwiche, N., 2429 Daugherty, C., 3045 Davis, R., 2996 Davisson, M.T., 481, 1463 de la Brousse, F.C., 1853 DeCaprio, J.A., 869, 2665 Decker, C.J., 855 DeGregori, J., 265 del Amo, F.F., 707 Deng, C.-X., 3045 D6rijard, B., 2996 Deschamps, J., 757 Detwiler, L., 959 DeVeaux, L.C., 203 Dever, C.A., 1678 DeVries, S., 2227 Di Leonardo, A., 2540 Dickson, B., 428 Diederich, B., 2653 Dimitrov, S., 1147 DiNardo, S., 105 Dixit, M., 2441 Dodd, J.A., 2349 Doherty, A.S., 290 Domen, J., 757 Donovan, J.D., 1640 Donovan, J.W., 2552 Dopping-Hepenstal, P.J.C.,

2563 Downs, W.D., 1198 Doyle, S., 2162 Draetta, G.F., 1627 Driks, A., 234 Dubois, E., 796 Dumont, D.J., 1897

Duncan, G., 2805 Duncan, R., 465 Duncan, S.A., 2466 Duronio, R.J., 440 Dynes, J.L., 948 Dynlacht, B.D., 1772 Dyson, E., 1007 Eady, R.A.J., 2563 Earp, H.S., 399 Ebright, R.H., 3058 Eckner, R., 869 Ede, K., 2729 Edgar, B.A., 440 Elenbaas, B., 1235 Elion, E.A., 313 Elledge, S.J., 2401 Ellenberger, T., 970 Emanuel, P.A., 830 Emerson, B.M., 2453 Emery, J., 2602 Enslen, H., 2527 Epstein, J.A., 2022 Ernst, J.-P., 2574 Errington, J., 2653 Esnayra, J., 2729 Esposito, R.E., 796 Evans, R.M., 538, 1007 Ewen, M.E., 869 Fangman, W.L., 554 Farifias, I., 2691 Farkas, R., 1160 Farnham, P.J., 1526 Fass, D., 970 Fearon, E.R., 1174 Fearer, W.J., 2868 Feldmann, K.A., 1388 Feng, G., 2913 Fenyo, D., 3058 Finberg, K., 1087 Fink, G.R., 1759, 2974 Finney, M., 1935 Firtel, R.A., 502, 948 Fischer, W.H., 502 Fisher, D.E., 2770 Flickinger, T.W., 914 Flock, G., 538 Flores, O., 1772 Fong, G.-H., 1897 Fortner, D.M., 221 Fox, C.A., 926, 1106 Frampton, J., 33 Francois, V., 2602 Freeman, K., 2257 Freytag, S.O., 1654 Friedberg, E.C., 2401 Friedrich, G.A., 2293 Friesen, H., 2162 Fuchs, E., 2574 Fuse, N., 2270 Gardner, H.A.R., 414 Garg, P., 1270 Gasch, A., 2363 Gebre-Medhin, S., 1875 Gehring, W.J., 899


Genetta, T., 2203 Gerasimova, T., 2046 Gerdes, M., 869 Gerety, S.J., 678 Gertsenstein, M., 1897 Gibson, T., 376 Gietz, R.D., 2035 Gigu6re, V., 538 Gilbert, J.D., 1654 Gilmour, D.S., 830 Ginsberg, D., 2665 Ginsburg, G.T., 2086 Giovane, A., 1502 Glaser, T., 2022 Glick, A.B., 2429 Glowacki, J., 277 Gober, J., 1839 Gold, L., 376 Gold, S., 2805 Golden, J.W., 74 Goldfarb, A., 3058 Goldstein, J.L., 1910 Goodrich, J.A., 515 Goto, K., 1548 Gottlieb, E., 1739 Gottschling, D.E., 1133 Gradwohl, G., 1897 Graf, T., 33 Graves, R.A., 1224 Gray, S., 1829 Greenstein, D., 1935 Greider, C.W., 563 Gridley, T., 707 Griep, A.E., 1285 Grimwade, B., 1087 Grosschedl, R., 2691 Grossniklaus, U., 899 Groudine, M., 2212 Guan, K.-L., 2939 Guarente, L., 2110 Gumeringer, C.L., 1007 Guthrie, C., 1071 Guy, C.T., 23 Hafen, E., 428 Hahn, S., 1920 Hall, P., 2151 Hallick, R.B., 1589 Han, M., 147 Harm, S.R., 2441 Hannon, G.J., 1750 Hansen, K.E., 1920 Hansen, M.J., 2770 Hardy, R.R., 1030 Harlow, E., 1772 Harpal, K., 3032 Harrington, J.J., 1344 Harrison, S.C., 970, 2504 Hartwell, L.H., 652 Hatakeyama, M., 1759 Hay, N., 2817 Hayashi, S., 2270 Heath, L.S., 2904 Hebron, C., 2913 Hedrick, L., 1174 Hemesath, T.J., 2770 Hendrick, L.L., 1984

Hengge-Aronis, R., 1600 Henkemeyer, M., 3032 Henry, N.L., 2868 Herr, W., 2756 Herrmann, B.G., 2137 Herrup, K., 2008 Herschlag, D., 1575 Herskowitz, I., 1367 Hipskind, R.A., 1803 Hird, S., 1935 Hirose, S., 2270 Hochschild, A., 1212 Hodgkinson, C.A., 2770 Holz, H., 3068 Hong, L., 1589 Horabin, I.I., 598 Horvitz, H.R., 160 Howes, K.A., 1300, 1738 Hsiao, K.-M., 1526 Hsu, J., 1270 Hsu, J.-C., 2176 Hu, E., 1224 Hu, N., 2008 Hua, X.H., 2058 Huang, M.S., 688 Huh, G.S., 1561 Hunt, T., 926 Hyer, J., 2743 Hynes, R.O., 1561 Iavarone, A., 1270 Ikeda, Y., 2302 Imai, Y., 328 Ingraham, H.A., 2302 Inostroza, J.A., 2097 Inouye, M., 2641 Iozzo, R.V., 2964 Iratni, R., 2928 Israel, A., 2491 Israel, M.A., 1270 J/ickel, A., 2574 Jackson, S.P. 2879 Jaenisch, R., 414 Jan, L.Y., 1787, 2123 Jan, Y.N., 1787, 2123 Jenkins, C.W., 2939 Jenkins, N.A., 265, 399, 1019,

1613, 2770, 2792 Jenny, A.L., 959 Jepeal, L., 2022 Jim6nez, C.G., 3068 Johnson, A.D., 2857 Johnson, A.L., 1640 Johnson, D.G., 1514 Johnson, P.F., 1131 Johnston, L.H., 1640 Jones, E.W., 1379 Jones, N., 885 Jongens, T.A., 2123 Jongeward, G.D., 60 Juven-Gershon, T., 1739 Kadesch, T., 2203 Kaiser, D., 2793 Kalderon, D., 2986 Kallunki, T., 2996 Kanaar, R., 1356, 1713 Kanllabiran, C., 2097

Kannan, P., 1258 Kapler, G.M., 84 Karaplis, A.C., 277 Karin, M., 2996 Karlsson, S., 2429 Kato, J.-y., 9 Kaufmann, J., 821 Keller, G., 1184 Kerkhoven, R.M., 2680 Keys, D.A., 2349 Khoo, B., 2879 Kim, S.K., 160 Kimmel, A.R., 2086 King, D.S., 1853 Kingsley, D., 133 Kingston, R.E., 386 Kinoshita, M., 1613 Kinzler, K.W., 1174 Kioussis, D., 770 Kirkegaard, K., 1726 Kiser, G.L., 652 Kispert, A., 2137 Kitamura, Y., 1473 Klebig, M.L., 481 Klein, W.H., 1 Klingensmith, J., 118 Klug, C.A., 678 Koff, A., 9 Kohara, Y., 1935 Kokontis, J.M., 2817 Komachi, K., 2857 Konarska, M.M., 1962 Konforti, B.B., 1962 Konrad, K.D., 1489 Komberg, R.D., 2868 Komfeld, K., 160 Kotecha, S., 1324 Kourilsky, P., 2491 Kowenz-Leutz, E., 2781 Kranz, J.E., 313 Kraut, N., 33 Kreitzer, D., 2151 Kremenstova, E., 2416 Krisak, L., 2151 Kronenberg, H,M., 277 Kronstad, J., 2805 Krug, R.M., 1817 Krutzsch, H., 465 Kuldell, N.H., 1212 Kulkarni, A.B., 2429 Kumar; S., 1613 Kurkulos, M., 2046 Kuroda, M.I., 96, 698 Kuspa, A., 948 Kuzin, B., 2478 Lackner, M.R., 160 Lala, D.S, 2302 Lamb, J., 811 Landick. R., 2913 Lane, E.B., 2563 Lane, M.E., 2986 Lane, W.S., 1920 Lange, R., 1600 Lansford, R., 1043 Lantz, V., 598 Larsson, E., 1875

Lasorella, A., 1270 Lasudry, J.G.H., 1300, 1738 Latham, K.E., 290 Lau, M.M.H., 2953 Lavendar, J., 96 Lawrence, J.B., 869 Lawrence, J.B., 2665 Lecourtois, M., 2491 Leder, P., 3045 Lee, A., 2324 Lee, B.N., 641 Lee, D.C., 399 Lee, E.Y.-H.P., 2008 Lee, J., 60 Lee, K., 1160 Lee, K.-F., 414 Lee, M.M., 2429 Lee, W.-H., 2008 Lees, I.A., 1772 Lefstin, J.A., 2842 Leigh, I.M., 2563 Leopold, P., 440 Leptin, M., 2137 Lerbs-Mache, S., 2928 Leutz, A., 2781 Lev6en, P., 1875 Levens, D., 465 Levine, A.J., 1235 Levine, M., 1247, 1829 Levine, M.S., 2588 Leviten, M.W., 2058 Li, H.-m., 339 Li, Y., 2939 Liao, X.C., 843 Liao, Y.J., 1787 Lieber, M.R., 1344 Lieberman, P.M., 995, 2324 Lin, J., 1235 Lincoln, A.J., 1131 Linders, K., 757 Lindsell, C.E., 707 Lingner, J., 1984 Linke, S.P., 2540 Liu, C., 2904 Liu, X., 190 Liu, Z., 2953 Livanos, E.M., 666 Livingston, D.M., 869, 2665 Logan, M., 1324 Logeat, F., 2491 Loomis, W.F., 948 Losick, R., 234 Louis, J.M., 2086 Lowell, C.A., 387 Lu, Y., 1817 Luehrsen, K.R., 1117 Luetteke, N.C., 399 Lunz, R., 2162 Luo, L., 1787, 2416 Luo, X., 2302 Lutz, C.S., 576 Luz, A., 277 Lygerou, Z., 1423 Ma, D., 2336 Ma, H., 745 Maas, R.L., 2022


Mache, R., 2928 Macleod, D., 2282 MacMillan, A.M., 3008 MacMorran, W.S., 2035 Madden, S.L., 720 Madhani, H.D., 1071 Madisen, L., 2212 Magnenat, L., 2389 Magnin, T., 2653 Mahdavi, V., 245 Maira, S.-M., 1502 Malim, M.H., 1538 Mallory, M.J., 2151 Maniatis, T., 1703 Manley, J.L., 259 Manova, K., 2466 Maquat, L.E., 363 Marks, M.D., 1388 Marmorstein, R., 2504 Marsh, J.L., 1489 Marvel, J., 770 Mason, E.D., 1489 Massague, J., 9 Matera, A.G., 2939 Matsuzaki, T., 45 Matthews, K.R., 491 Matzuk, M.M., 414 Maurer, R.A., 2527 Mavilio, F., 732 Maxon, M.E., 515 Mazo, A., 2478 McGill, G., 2770 McKearin, D.M., 614 McKnight, S.L., 1853 McLean, W.H.I., 2563 McMahon, A.P., 174 McMahon, J.A., 174 McMahon, S.L., 1526 McMillan, J.R., 2563 McNagny, K.M., 33 Melchers, F., 1043 Mendelsohn, M., 1043 Mermelstein, F.H., 2097 Messenguy, F., 796 Meyer, B.E., 1538 Meyerowitz, E.M., 1548 Michaud, E.J., 481, 1463 Michelotti, G., 465 Miller, L.M., 160 Milne, G.T., 2552 Mitchell, P., 1423 Miyagawa, T., 45 Mizrokhi, L v 2478 Mlodzik, M., 2313 Mohun, T.J., 1324 Montell, C., 981 Moore, G., 2996 Moore, M.J., 587 Moore, P.A., 2324 Moran, Jr., C.P., 234 Moretti, P., 2257 Mori, I., 2389 Mueller, C.G.F., 1920 Muhlrad, D., 855 Mullen, J.R., 105 Mfiller, F., 2389

Muller, W.J., 23 Mulligan, R.C., 277 Mullins, J., 2282 Murillo, F.J., 2375 Muthuswamy, S.K., 23 Myung, P.S., 2527 Nachtigal, M.W., 2302 Najafi, S.M.A., 2653 Nasmyth, K., 885 Navsaria, H.A., 2563 Nemazee, D., 1030 Nerlov, C., 350 Nesic, D., 363 Neuhaus, G., 2188 Neuman, S., 959 Nevins, J.R., 1514 Newsome, D., 869 Newton, M.A., 2227 Nichols, M.A., 2939 Nicolas, F.J., 2375 Nilson, J.H., 2302 Noda, M., 1613 Nogi, Y., 2349 Nomura, M., 2349 Nordheim, A., 1803 Nordlund, M.L., 1019, 2792 Novak, J.E., 1726 Nusse, R., 118 Nussenzweig, M.C., 1030 O'Brien, C.A., 2891 O'Connor, M.B., 2588 O'Farrell, P.H., 440 O'Keefe, C.L., 2939 O'Neill, J.W., 2602 Oehlen, L.J.W.M., 1058 Ogura, K.-i., 2389 Ohsako, S., 2743 Ohshima, Y., 2389 Ohtani, K., 1514 Okamura, R.M., 2691 Okano, H., 981 Oki, T., 45 Oliver, I., 2743 Olson, E.N., 1 Ong, E., 538 Oren, M., 1739 Orkin, S.H., 1184 Ornitz, D.M., 3045 Otulakowski, G., 538 Ozer, J., 2324 Paetkau, D.W., 2035 Pagano, M., 1627 Paielli, D.L., 1654 Palmer, M.J., 96 Palmer, M.J., 698 Pan, H., 1285 Panganiban, G., 2743 Papermaster, D.S., 1300, 1738 Parada, L.F., 1019, 2792 Parker, K.L., 2302 Parker, R., 855 Parslow, T.G., 2691 Patel, N.H., 981 Payre, F., 2718 Peculis, B.A., 2241 Pekny, M., 1875

Penner, J., 2964 Perkins, A.S., 1019, 2792 Perrimon, N., 118, 300, 629,

2176 Petfalski, E., 1423 Pfeifer, K., 1867, 2227 Philipson, L., 453 Phillips, H.K., 399 Pintzas, A., 1502 Piscitelli, C., 3021 Pitera, R., 2563 Plasterk, R.H.A., 1935 Plump, A.S., 2466 Polyak, K., 9 Pooh, D., 2868 Posakony, J.W., 2058, 2729 Prakash, L., 811 Prakash, S., 811 Prezioso, V.R., 2466 Price, J., 1007 Priyaranian, P., 265 Proudfoot, N.J., 259 Proweller, A., 2629 Prusiner, S.B., 959 Puri, M.C., 1897 Purnell, B.A., 830 Qian, X.-Y., 1817 Qiu, T.H., 399 Query, C.C., 587, 3008 Quo, R.-G., 2691 Rabinow, L., 1160 Raghuraman, M.K., 554 Ramasubramanian, T.S., 74 Ramaswamy, K.S., 74 Ransom, N., 1300, 1738 Rao, Y., 939 Rather, N., 1019, 2792 Rauscher III, F.J., 720 Rayburn, H., 265 Redd, M.J., 2857 Reed, R., 1974 Reichman-Fried, M., 428 Reid, S.W., 1019, 2792 Reinberg, D., 2097, 2336 Ren, R., 783 Retie, W.G., 1388 Reuter, R., 2137 Reznikoff, C.A., 2227 Reznikoff, W.S., 2363 Rice, N.R., 678 Richman, R., 96, 698 Richter, L., 698 Riese, J.A., 2035 Ringquist, S., 376 Rio, D.C., 1713 Rivellini, F., 3021 Robanus-Maandag, E., 757 Roberts, J.M., 9 Roberts, R.L., 2974 Roeder, G.S., 1087 Roels, S., 234 Rolink, A., 1043 Roman, C.A.J., 1030 Ron, D., 453, 2513 Rosa, F.M., 1448 Rosbash, M., 843

Rosen, C.A., 2324 Rosenberg, N., 678, 688 Ross-Macdonald, P.B., 1087 Rossant, J., 3032 Roth, S.Y., 1400 Rotwein, P., 2953 Rowe, L.B., 1853 Rugg, E.L., 2563 Ruiz-Vfizquez, R.M., 2375 Ruley, H.E., 265 Rupp, R.A.W., 1311 Ruppert, S., 2756 Rusch, J., 1247 Russ, A., 265 Ruvkun, G., 1935 Sager, B., 2793 Salz, H.K., 914 Sarkiss, M., 1258 Sartori, D., 732 Sato, R., 1910 Satterberg, B., 313 Savelieva, E., 2227 Schedl, P., 598 Schlissel, M.S., 1030 Schmitt, M.E., 2617 Schneider, D., 376 Schnitzler, G.R., 502 Schultz, R.M., 290 Schweisguth, F., 2491 Scott, C.D., 290 Sealy, L., 2441 Sears, R.C., 2441 Sedkov, Y., 2478 Segall, J., 2162 Sekhon, G., 2227 S6raphin, B., 1423 Severinov, K., 3058 Shah, P.C., 678 Sharma, P.M., 720 Sharp, P.A., 587, 3008 Shaulsky, G., 948 Shea, M.J., 174 Sheets, M.D., 926 Sheldon, L.A., 386 Sheldon, M., 2336 Shen, M.M., 3045 Shen, W.-H., 2302 Sherr, C.J., 9 Shilo, B.-Z., 428 Shinkai, Y., 1043 Shinton, S.A., 1030 Shore, D., 2257 Siebel, C.W., 1713 Siede, W., 2401 Silver, D.P., 1030 Simpson, R.T., 1400 Singh, H., 678 Singson, A., 2058 Sitnicka, E., 2831 Sluss, H.K., 2996 Smale, S.T., 821 Smith, G.R., 203, 1693 Snider, L., 1311 Snyder, M., 1087 Sobieszczuk, P., 1502 Sofroniew, M., 757


Solloway, M., 2602 Solomon, M.J., 9 Song, S.U., 2046 Soriano, P., 23, 387, 1888,

1999, 2293 Spanopoulou, E., 1030 Sparrow, D., 1324 Spiegelman, B.M., 1224 Sprenger, F., 440 Spyropoulos, D.D., 1949 Stargell, L.A., 1335 Stark, K.L., 174 Stavenhaven, J.B., 1411 Steber, C., 796 Steffan, J.S., 2349 Stein, P.L., 1999 Steingrimsson, E., 2770 Steitz, J.A., 2241, 2704 Sternberg, P.W., 60 Stewart, C.E.H., 2953 Stewart, C.L., 2953 Strich, R., 796, 2151 Strubin, M., 1335 StruM, K., 525, 1335 Stunnenberg, H.G., 3068 Su, B., 2996 Sucov, H.M., 1007 Suhan, J., 1379 Sukumar, S., 720 Sun, P., 2527 Sun, X., 2336 Sung, P., 811 Surosky, R.T., 796 Swedlow, J.R., 2123 Sweet, H.O., 481, 1463 Swiatek, P.J., 707 Swolin, B., 1875 Szymanski, P., 1829 Tabaee, A., 453 Tainsky, M.A., 1258 Takada, S., 174 Takeda, H., 45 Takeda, T., 885 Tam, S.W., 1627 Tang, H., 3058 Tansey, W.P., 2756 Tam, W.-Y., 2704 te Ride, H., 757 Theodoras, A.M., 1627 Thomas, J.R., 2842 Thompson, K.J., 2227 Thomer, J., 1920 Tian, M., 1703 Tilghman, S.M., 1867 Tillib, S., 2478 Tini, M., 538 Tjian, R., 515, 2313, 2756 Tlsty, T.D., 666 Tobler, H., 2389 Tollervey, D., 1423 Tomonaga, T., 465 Tontonoz, P., 1224 Towers, N., 1324 Toyn, J.H., 1640 Treisman, R., 1664 Troy, R.G., 221

Tsai, S., 2831 Tschudi, C., 491 Tsigelny, I., 2996 Tuan, R.S., 2151 Tumbough Jr., C.L., 2904 Turner, B.M., 96 Turner, D.L., 1434 Twamley, G., 2781 Tybulewicz, V.L.J., 277 Ullu, E., 491 Vairo, G., 2665 Valcfircel, R., 3068 van der Lugt, N.M.T., 757 van der Valk, M., 757 Van Doren, M., 2729 van Genderen, C., 2691 van Lohuizen, M., 757 van Roon, M., 757 van Vugt, M.J., 1463 Vande Woude, G., 926 Vandekerckhove, J., 2491 Varmus, H.E., 387 Vassalli, A., 414 Vassileva, G., 174 Vaught, J., 2770 Verdine, G.L., 3008 Verrijzer, C.P., 2313 Vilardell, J., 211 Vincent, A., 2718 Vogel, H., 1999 Vogel, K.S., 1019, 2792 Vogelstein, B., 1174 yon Melchner, H., 265 Voorhoeve, P.M., 2680 Vu, L., 2349 Wagner, A.J., 2817 Wahl, G.M., 2540 Wahle, E., 1106 Wahls, W.P., 1693 Walbot, V., 1117 Waldman, F., 2227 Walter, J., 1678 Walton, D.S., 2022 Wang, B., 1935 Wang, J., 2072 Wang, L.C., 688 Warner, J.R., 211 Wasylyk, B., 1502 Weaver, D.T., 2552 Webb, C.D., 1489 Well, P.A., 2868 Weilbaecher, R., 2913 Weinberg, R.A., 1759 Weinert, T.A., 652 Weinmaster, G., 707 Weinreich, M.D., 2363 Weinstein, D.C., 2466 Weintraub, H., 1311, 1434,

2203 Weiss, M.J., 1184 Westaway, D., 959 Weston, K., 770 Whipple, F.W., 1212 White, A.E., 666 Wickens, M., 926, 1106 Wicky, C., 2389

Widner, K.L., 2665 Wilkinson, J.F., 2653 Williams, S.C., 1131 Wilson-Heiner, M., 2964 Windle, J.J., 1300, 1738 Wingrove, J.A., 1839 Winter, E., 2151 Winters, R.S., 2151 Withers-Ward, E.S., 1473 Wittbrodt, J., 1448 Wolffe, A.P., 1147 Wolin, S.L., 2891 Woods, R.A., 2035 Woychik, R.P., 481, 1463 Wu, T.-C., 1174 Wu, X., 2939 Wu, Y., 147 Wynshaw-Boris, A., 3045 Xiao, Z.-X., 2665 Xiong, W.-C., 981 Xiong, Y., 2939 Xu, G., 2665 Yamagata, H., 2188 Yamaguchi, T.P., 3032 Yamamoto, K.R., 2842 Yamamoto, M., 328 Yamamoto, R.T., 2349 Yang, J., 1910 Ye, Z.-S., 783 Yeager, T., 2227 Yeung, K., 2336 Yeung, K.C., 2097 Yew, P.R., 190 Yim, S.O., 1258 Yokomori, K., 2313 Young, F., 1043 Yu, Q.-C., 2574 Yuan, S.-S.F., 2008 Yudkin, M.D., 2653 Yun, B., 1160 Yuspa, S.H., 2429 Zabel, B., 2574 Zakian, V.A., 1411 Zappavigna, V., 732 Zeidler, M.P., 2313 Zhai, Y., 2227 Zhang, H., 1750 Zhang, L., 2110 Zhou, Z., 2401 Zhu, L., 2680 Zhu, Y., 885 Ziff, E.B., 350 Zinszner, H., 2513 Zuliani, V., 959


Subject Index, Volume 8 (1994)

Abelson murine leukemia, early B-cell development (Chen et al.), 688- 697

Abelson murine leukemia virus, transformation of B-lineage precur- sors (Klug et al.), 678-687

Abl protein-tyrosine kinase, selective binding sites for SH3 domains of Crk and Nck (Ren et al.), 784-795

Achaete-scute homolog, Xenopus, expression of and effect on cell fate (Turner and Weintraub), 1434-1447

achaete transcriptional repression by hairy

(Ohsako et al.), 2743-2755 transcriptional repressor of hairy (Van

Doren et al.), 2729-2742 Activation target, of lac promoter de-

fined by mutations (Tang et al.), 3058-3067

Activin, dominant-negative variants in fish (Michaud et al.), 1463-1472

Activin/inhibin BB subunit gene, role in mouse eyelid development and female reproduction (Vassalli et al.), 414-427

Adapter molecules, Crk, Nck, and Grb2 SH3 domains (Ren et al.), 783- 795

Adenovirus 2 early 1B (Ad2 EIB), binding to amino terminus of p53 (Lin et al.), 1235-1246

Adenovirus E1A-associated proteins, p300 has transcriptional adaptor properties (Eckner et al.), 869- 884

Adenovirus E1B 55K, negative regulation of p53 activity (Yew et al.), 190-202

Adenylate cyclase, control of morphogenesis in U. maydis (Gold et al.), 2805-2816

ADI (ATP-dependent inhibitor), encoded by MOT1 gene (Auble et al.), 1920-1934

Adipocyte enhancer, tissue-specific regulator of, mPPARy2 (Tontonoz et al.), 1224-1234

Adipogenesis, promoted by C/EBPa (Freytag et al.), 1654-1663

Adipose tissue, G1/S growth arrest blocked by oncogene TLS- CHOP (Barone et al.), 453-464

Agouti, new dominant mutation A iapy

(Michaud et al.), 1463-1472 Agouti mice locus, reverse mutations (a

to a t and A w) (Bultman et al.), 481--490

a-factor, yeast mating pheromone (Oeh- len and Cross), 1058-1070

Alternative splicing Drosophila sex determination (Wang

and Bell), 2072-2085 of Drosophila Sxl sex determination

gene (Flickinger and Salz), 914- 925

of the Euglena gracilis ycf8 complex trinitron (Hong and Hallick), 1589-1599

factor, RNA-binding protein PSI (Sie- bel et al.), 1713-1725

of fibronectin mRNA, regulation by hexanucleotide element (Huh and Hynes), 1561-1574

mRNA, of Pax6 paired box subdomains (Epstein et al.), 2022-2134

RNA, generates distinct amino-terminal domains of ROR isoforms (Gigu6re et al.), 538-553

of zebrafish pou2 gene (Takada et al.), 45-59

Amino-terminal domain, p53, hydrophobic amino acids in (Lin et al.), 1235-1246

Anabaena, xisF gene, encodes develop- mentally regulated site-specific recombinase (Carrasco et al.), 74-83

Androgenone, and genomic imprinting (Latham et al.), 290-299

Anemia, with erythroblastosis and thrombocytopenia in PDGF B-deficient mice (Lev6en et al.), 1875-1887

Aniridia human congenital eye disease, mutated PAX6 gene (Epstein et al.), 2022-2034

Anteroposterior (A/P)patterning. See also Patterning

Anteroposterior axis, of Drosophila, disruption of PKA disrupts RNA localization (Lane and Kal- deron), 2986-2995

Antirepression, activity of TFIIA (Sun et al.), 2336-2348

Antirrhinum majus, flower development (Ma), 745-756 Review

aP2, adipocyte-specific gene (Tontonoz et al.), 1224-1234

AP47 mouse protein, equivalency to nematode UNC-101 protein (Lee et al.), 60-73

AP-2 transcription factor, transformation by N-ras oncogene (Kannan et al.), 1258-1269

Apoptosis. See also Cell death E7 induced (Pan and Griep), 1285-

1299 induction of by mouse Nedd2 gene

(Kumar et al.}, 1613-1626 induction of requires p53 (Howes et

al.), 1300-1310 in RB mutant mice (Lee et al.), 2008-

2021

role of p53 and Myc (Wagner et al.), 2817-2830

aprt. See Phosphoribosyltransferase (Ma- cleod et al.), 2282-2292

Arabidopsis thaliana floral homeotic gene PISTILLATA (PI)

(Goto and Meyerowitz), 1548- 1560

flower development (Ma), 745-756 Re- view

phototransduction pathway (Li et al.), 339-349

role of GL2 homeo box gene in trichome development, role of GL2 homeo box gene (Rerie et al., 1388-1399

Arabinose, (Query et al.), 587-597 ARF6, adipocyte transcription factor

(Tontonoz et al.), 1224-1234 Arginine, rare codons regulate expression

(Chen and Inouye), 2641-2652 Asexual sporulation, Aspergillus (Lee

and Adams), 641-651 Aspergillus nidulans, fluG gene required

for production of extracellular signal (Lee and Adams), 641- 651

Asymmetric binding, by HAP1 homodimers (Zhang and Guar- ente), 2110-2119

aurea, phytochrome control of gene expression (Bowler et al.), 2188- 2202

Autoantigen, binding to mutant 5S rRNA (O'Brien and Wolin), 2891-2903

Autoregulatory control, of E2F1 gene expression during cell cycle progression (Johnson et al.), 1514- 1525

Autosomal dominant disorder, neurofibromatosis type 1 (NF1) (Bran- nan et al.), 1019-1029

Avian leukosis virus (ALV), distribution of targets for DNA integration in vivo (Withers-Ward et al.), 1473-1487

Axial organization, development regulated by FGFR-1 (Deng et al.), 3045-3057

Axon elongation, role of C. elegans unc-51

(Ogura et al.), 2389-2400 guidance, role of C. elegans unc-51

(Ogura et al.), 2389-2400 outgrowth, involvement of Drosophila

Dracl (Luo et al.), 1787-1802

B

B cells development

role of retinoic acid receptors (Tsai et al.), 2831-2841


v-abl tyrosine kinase supresses light-chain rearrangement (Chen et al.), 688-697

differentiation components of the immunoglobulin

antigen receptor, regulory role of (Spanopoulou et al.), 1030- 1042

influence of immunoglobulin expression on (Young et al.), (1043-1057)

Bacillus subtilis interactions between SpoIIAA and

SpoIIAB regulate transcription- (Diederich et al.), 2653-2663

SpolVCA recombinase, similarity to Anabaena XisF protein (Car- rasco et al.), 74-83

subcellular localization in coat assembly (Driks et al.), 234-244

Bacteriophage T4, group I introns, self- splicing properties (Coetzee et al.), 1575-1588

Basal factors, TFIIE interactions (Maxon et al.), 515-524

Basidiomycete fungus, Ustilago maydis (Banuett and Herskowitz), 1367-1378

~-Globin, transcriptional regulation (Bar- ton and Emerson), 2453-2465

[3' subunit, of RNA polymerase, role in chain elongation (Weilbaecher et al.), 2913-2927

bHLH domain, of transcription factor E47 (E1-

lenberger et al.), 970-980 escargot, role in Drosophila develop-

ment (Fuse et al.), 2270-2281 factors, in myogenesis (Olson and

Klein), 1-8 Review mi role in DNA binding and transcrip-

tional activation (Hemesath et al.), 2770-2780

MyoD and El2 (Weintraub et al.), 2203-2211

-Zip transcription factors, role of SREBP-2 in cholesterol homeostasis (Yang et al.), 1910-1919

bicoid regulation by PKA in Drosophila

oocytes (Lane and Kalderon), 2986-2995

transcription controlled by serendipity (Payre et al.), 2718-2728

Binuclear duster, of PPR1 and GAL4, role in DNA binding (Marmor- stein and Harrison), 2504-2512

Blastocyte outgrowth, (Spyropoulos and Capecchi), 1949-1961

Blue light, signal pathways in M. xanthus (Nicolas et al.), 2375-2387

bmi-1 proto-oncogene, developmental defects in bmi-1 mutants (van der Lugt et al.), 757-769

Brachyury mouse gene, Xenopus (Xbra) homolog of (Rao), 939-947

Branch nucleophile selection, bulged duplex model (Query et al.), 587- 597

Branch site, of pre-mRNA, identification of associated proteins (Mac- Millan et al.), 3008-3020

Branchpoint sequence, U2 snRNP binding (Champion-Amaud and Reed), 1974-1983

Breathless, Drosophila FGF receptor homolog, role in tracheal cell migration (Reichman-Fried et al.), 428-439

BRF, cloning of homologs from K. lactis and C. albicans {Khoo et al.), 2879-2890

Bronze-2 (Bz2) gene, maize (Luehrsen and Walbot), 1117-1130

Budding regulation by uacl and ubcl in U.

maydis (Gold et al.), 2805-2816 in S. cerevisiae, involvement in mat-

ing and invasive growth (Rob- erts and Fink)i 2974-2985

Budding yeast. See Saccharomyces cerevisiae

Bulged duplex model, branch nucleophile selection (Query et al.), 587-597

Burkitt's lymphoma, role of IgH and c-myc genes (Madisen and Grou- dine), 2212-2226

C/EBP family,. CHOP (GAD153) (Barone et

al.), 453-464 transcriptional activation by c-myc

(Hann et al.), 2441-2452 C/EBP~, promotes adipogenesis in

mouse fibroblastic cells (Freytag et al.), 1654-1663. See also CCAAT/enhancer binding protein-a

C/EBP~, phosphorylation-induced activation by derepression (Ko- wenz-Leutz et al.), 2781-2791

c/ebp gene, revised sequence (Lincoln et al.), 1131-1132

c/ebp sequence. (Landschulz et al.), 786- 800 (Lincoln et al.), 1131-1132

c-Jun, cloning of JNK2 (Kallunki et al.), 2996-3007

c-myc expression stimulated by FBP (Duncan

et al.), 465-480 deregulation in plasmacytomas (Mad-

isen and Groudine), 2212-2226 c-Myc, regulation of transcription (Hann

et al.), 2441-2452 c-Src tyrosine kinase, required for mam-

mary tumorigenesis (Guy et al.), 23-32

Caenorhabditis elegans cell death gene ced-3 (Kumar et al.),

1613-1626 POU homeo box gene ceh-18, targeted

mutations in (Greenstein et al.), 1935-1948

unc-51 gene required for axonal elongation (Ogura et al.), 2389-2400

unc-lO1 gene encodes clathrin-associated protein (Lee et al.), 60-73

vulval induction, role of MAP kinase homolog mpk-1 (Lackner et al.), 160-173

vulval signaling pathway, role of Sur-1 MAP kinase (Wu and Han), 147-159

Calcium influx, role in activation of CREB (Sun et al.), 2527-2539

Calcium-dependent, gene expression in plants (Bowler et al.), 2188- 2202

Calcium/calmodulin-dependent protein kinase, phosphorylation of CREB (Sun et al.), 2527-2539

cAMP regulation

by CREB (Sun et al.), 2527-2539 of morphogenesis in U. maydis

(Gold et al.), 2805-2816 signaling, late Dictyostelium develop-

ment, pattern formation and cell differentiation (Louis et al.), 2086-2096

Cancer, Wilms' tumor (WT) or nephro- blastoma (Sharma et al.), 720- 731

Candida albicans, cloning of BRF homolog (Khoo et al.), 2879-2890

CAP-dependent transcription, determination of activation target for lac promoter (Tang et al.), 3058- 3067

CAR4, cAMP receptor, late Dictyostel- ium development (Louis et al.), 2086-2096

CAR80/CARGRI, identical to UME6 (Strich et al.), 796-810

Car, role in blue light response in M. xanthus (Nicolas et al.), 2375- 2387

Carcinogenesis, loss of genomic integrity (White et al.), 666-677

Cardiac dilation, in PDGF B-deficient mice

[Leyden et al.), 1875-1887 morphogenesis, mice, vitamin A sig-

naling pathway (Sucov et al.), 1007-1018

muscle-specific transcription, Xeno- pus embryos, regulated by SL1 protein (Chambers et al.), 1324- 1334

Cardiogenesis, role of TEF-1 in mice (Chen et al.), 2293-2301

Cardiomyopathy, from loss of Igf2r (Lau et al.), 2953-2963


Carotenoid genes, in M. xanthus (Nico- l~is et al.), 2375-2387

Caulobacter, pole-specific repression in (Wingrove and Gober), 1839- 1852

CCAAT displacement protein, mammalian counterpart of Drosophila Cut homeo protein (Andr6s et al.), 245-257

CCAAT/enhancer binding protein-~ (C/ EBP% transcriptional activation of serum albumin •promoter (Nerlov and Ziff), 350-362

Cdc2 kinase, cell cycle regulator in Drosophila (Edgar et al.), 440- 452

Cdc28 kinase activity, down-regulation of in S. cerevisiae late mitosis (Donovan et al.), 1640-1653

Cdc28p protein kinase, yeast, activation of by G1 cyclins (Oehlen and Cross) (1058-1070)

CDF2, role as repressor of transcription • initiation (Iratni et al.), 2928- 2938

CDK4, identification of associated proteins {Guan et al.), 2939-2952

CDK6, identification of associated proteins (Guan et al.), 2939-2952

CDK inhibitor, P40 sDB2s, role in S. cerevisiae M/G1 transition (Dono- van et al.), 1640-1653

CED-3, gene product of C. elegans ced-3 gene, mouse Nedd2 gene encodes protein similar to (Kumar et al.), 1613-1626

ceh-18 C. elegans gene, new member of POU homeo box genes (Green- stein et al.), 1935-1948

Cell-cell interactions, and Dictyostel- ium LagC protein (Dynes et al.), 948-958

Cell commitment, gastrula stage, zebrafish pou2 gene (Takada et al.), 45-59

Cell cycle arrest

G1 phase, and S. pombe mating pheromone P-factor (Imai and Yamamoto), 328-338

control, mitotic checkpoint genes in budding yeast (Weinert et al.), 652-665

by inhibitor p27 Kipa (Polyak et al.), 9-22

control differential disruption of genomic

integrity in HPV-infected NHF (White et al.), 666-677

by Myc and p53 (Wagner et ai.), 2817-2830

progression, hyperphosphorylation of pRB during G 1 (Hatakeyama et al.), 1758-1771

role of p53 (Di Leonardo et al.), 2540-2551

by SAD1 (Allen et al.), 2401-2415 yeast, mechanism of position-effect

variegation (Aparicio and Gott- schling), 1133-1146

differential phosphorylation of E2F-4 (Ginsberg et al.), 2665-2679

G1/S arrest, CHOP, and TLS-CHOP (Barone et al.), 453-464

M/G1 transition in S. cerevisiae, role of P4oSDB2S (Donovan et al.), 1640-1653

multiple modes of regulation during Drosophila embryogenesis (Ed- gar et al.), 440-452

progression active cyclin kinases in quartemary

complex (Zhang et al.), 1750- 1758

G1 into S phase (Johnson et al.), 1514-1525

G1 to S phase (Hsiao et al.), 1526- 1537

role of E2F-4 (Beijersbergen et al.), 2680-2690

role of RB protein (Lee et al.), 2008- 2021

regulation of E2F transcription factor (Dyn-

lacht et al.), 1772-1786 and p21 function (Zhang et al.),

1750-1758 Cell death. See also Apoptosis

mouse Nedd2 gene product is similar to product of C. elegans ced-3 gene and mammalian IL-lf~- converting enzyme (Kumar et al.), 1613-1626

role of HNF-4 in mouse embryonic ec- toderm (Chen et al.), 2466-2477

Cell differentiation, and suppression of ld gene activity (Iavarone et al.), 1270-1284

Cell fate Drosophila

dorsoventral patterning (Mason et al.), 1489-1501

germ-cell specification (Jongens et al.), 2123-2136

and Xenopus achaete-scute homolog expression (Turner and Wein- traub), 1434-1447

Cell migration; Drosophila tracheal development, role of breathless (Reichman-Fried et al.), 428- 439

Cell movement, M. xanthus C-factor (Sager and Kaiser), 2793-2804

Cell proliferation, effect of HLH protein Id-2 on {Iavarone et al.), 1270- i284

Cerebellum, neurological abnormalities in bmi-1 mutant mice {van der Lugt et al.), 757-769

cGMP, role in chloroplast development (Bowler et al.), 2188-2202

Chain elongation, mutations in [3' sub-

unit of E. cob RNA polymerase (Weilbaecher et al.), 2913-2927

Checkpoint genes, budding yeast (Wei- nert et al.), 652-665, 948-958

Checkpoints cell cycle regulation [White et al.),

666-677 SAD1 and DNA damage (Allen et al.),

2401-2415 Chemotaxis, role of C-factor in M. xan-

thus (Sager and Kaiser), 2793- 2804

Chlorophyll a/b-binding protein, Arabi- dopsis (Li et al.), 339-349

Chloroplast, of Euglena gracilis, complex twintron within ycf8 gene (Hong and Hallick), 1589-1599

Chloroplasts, regulation of rDNA transcription (Iratni et al.), 2928-2938

CHO cells, sterol-resistant transcription in {Yang et al.), 1910-1919

Cholesterol homeostasis, and transcription factor SREBP-2 {Yang et al.), 1910-1919

Chondrocyte proliferation, role of PTHrP gene (Karaplis et al.), 277-289

Chondrodysplasia. See also Osteochon- drodysplasia

CHOP, binding to TLS and EWS, transformation of NIH-3T3 cells (Zinszner et al.), 2513-2526

CHOP (GADD153), growth arrest and DNA damage-inducible gene {Barone et al.), 453--464

Chromatin histone H1 incorporation and 5S

rRNA gene transcription (Bou- vet et al.), 1147-1159

repressive regions of (Cooper et al.), 1400-1410

role in transcription (Barton and Emer- son), 2453-2465

and transcriptional control in yeast (Aparicio and Gottschling), 1133-1146

Chromosome alterations induced by HPV16 E6 (Rez-

nikoff et al.), 2227-2240 breakage, Tetrahmena thermophila

rDNA minichromosome (Ka- pler and Blackburn), 84-95

binding, of Drosophila trithorax (Ku- zin et al.), 2478-2490

ends, maintenance of and telomerase (Autexier and Greider), 563-575

replication, origin activation (Ra- ghuraman et al.), 554-562

transcription of ~-globin (Barton and Emerson), 2453-2465

chs, regulation by cGMP and calcium (Bowler et al.), 2188-2202

Cipl, induction of p53 (Di Leonardo et al.), 2540-2551

Glass II genes, Drosophila, TFIID sequence


recognition of initiator and downstream sequences (Purnell et al.), (830-842)

promoters, Drl repression of (Yeung et al.), 2097-2109

Clathrin-associated protein, encoded by C. elegans unc-lO1 (Lee et al.), 60-73

Cloning, of E2F-4 (Beijersbergen et al.), 2680-2690, (Ginsberg et al.), 2665-2679

CNS. See also Neural development Coactivator, activity of human TFIIA-~/

(Ozer et al.), 2324-2335 Coat assembly, B. subtilis, subcellular

~ !ocalization of proteins (Driks et al.), 234-244

Codon usage, in E. coli (Chen and In- ouye), 2641-2652

Coiled-coil oligomerization, in GABPI3 transcription factor (de la Brousse et al.), 1853-1865

Colorectal tumorigenesis, and human DCC gene product (Hedrick et al.), 1174-1183

Commitment complex (pre-mRNA-U1 snRNP), yeast spliceosome assembly (Abovich et al.), 843- 854

Complex promoter, multiple enhancers function autonomously (Gray et al.), 1829-1838

Complex twintron, within Euglena gracilis chloroplast ycf8 gene (Hong and Hallick), 1589-1599

Conceptus, mouse, postimplantation le- thality of (Spyropoulos and Capecchi), 1949-1961

Connective growth factor (CTGF), human, weak resemblance to Drosophila protein encoded by twisted gastrulation gene (Ma- son et al.), 1489-1501

Contact inhibition, and cell cycle arrest (Polyak et al.), 9-22

Cooperative binding, to DNA (Whipple et al.), 1212-1223

Cooperative protein-protein interactions, cut repeat and homeo domain of the cut homeo proteins (Andr6s et al.), 245-257

CotE B. subtilis protein, {Driks et al.), 234-244

CpG islands, methylation regulated by SP1 (Macleod et al.), 2282-2292

CPSF (polyadenylation specificity factor), and cytoplasmic polyadenylation {Bilger et al.), 1106--1116

CREB phosphorylation by calcium/calmodu-

lin-dependent protein kinase (Sun et al.), 2527-2539

transcriptional activation (Sun et al.), 2527-2539

Crk adapter protein, SH3 domain binds to Abl (Ren et al.), 783-795

Cryptic splice sites, Tetrahymena group I intron (Downs and Cech), 1198-1211

Crystal structure, of PPR1-DNA complex (Marmorstein and Harri- son), 2504-2512

Cut homeo proteins, bipartite DNA- binding protein {Andrds et al.), 245-257

Cyanobacteria, Anabaena heterocyst differentiation (Carrasco et al.), 74-83

Cyclin 3' UTR of stimulates translation

by regulating polyadenylation (Sheets et al.), 926-938

cell cycle regulator in Drosophila (Ed- gar et al.), 440--452

Cyclin-dependent kinase inhibitor

correlation of growth suppression with pRb function (Guan et al.), 2939-2952

regulation by p53 (Wagner et al.), 2817-2830

kinases (cdks) cyclin E-Cdk2 complexes, p27 Kip1

inhibitor binds complexes and inhibits activation {Polyak et al.), 9-22

role in hyperphosphorylation of pRB (Hatakeyama et al.), 1758-1771

Cyclin D1, inhibition of DNA synthesis (Pagano et al.), 1627-1639

Cyclin kinases, p21-containing (Zhang et al.), 1750-1758

Cyclization, Tetrahymena RNA splicing (Downs and Cech), 1198-1211

D

Danforth's short tail (Sd) gene, mouse mutation (Swiatek et al.), 707- 719

Darkener of apricot {Doa) locus, Droso- phila, eye and embryonic development (Yun et al.), 1160-1173

Dbf2 protein kinase, S. cerevisiae, function in late mitosis (Donovan et al.), 1640-1653

DCC human gene product, differentiation and tumorigenesis {He- drick et al.), 1174-1183

Dcdc42, GTPase subfamily (Luo et al.), 1787-1802

Deadenylation, triggers decay of MFA2 mRNA (Muhlrad et al.), 855- 866

Decapentaplegic {DPP) signaling molecule, and dorsal midline cell fate (Mason et al.), 1489-1501

Decapping, of mRNA (Muhlrad et al.), 855-866

Derepression, as a mechanism for acti- vating NF-M (Kowenz-Leutz et al.), 2781-2791

Desensitization, of cGMP and calcium signals (Bowler et al.), 2188- 2202

Development of Drosophila regulated by escargot

(Fuse et al.), 2270-2281 HNF-4 and mouse embryo {Chen et

al.), 2466-2477 role of targeted gene disruption (Chen

et al.), 2293-2301 Developmental mutant, of Dictyostel-

ium discoideum (Dynes et al.), 948-958

Developmental regulation, Wilms' tumor susceptibility gene (Sharma et al.), 720-731

DFGF-R1. See Breathless Dictyostelium discoideum

cAMP signaling required for pattern formation and cell differentiation (Louis et al.), 2086-2096

G-box binding factor (GBF) and developmental switch from early to late development (Schnitzler et al.), 502-514

LagC protein functions as cell-cell signaling molecule (Dynes et al.), 948-958

Differential gene expression, on new dominant agouti allele {A iapy) (Michaud et al.), 1463-1472

Differentiation and human DCC gene product (He-

drick et al.), 1174-1183 -specific activation of gene expression

{Nerlov and Ziff), 350-362 Dimer-dimer interactions, specificity

determinants for (Whipple et al.), 1212-1223

Dimerization , coiled-coil dimerization between GABPI~ subunits {de la Brousse et al.), 1853-1865

Dimorphism role of MAP kinase pathway in S. cer-

evisiae (Roberts and Fink), 2974-2985

See also Fungal dimorphism Diploidy, regulation by Drosophila es-

cargot (Fuse et al.), 2270-2281 Direct repression, by adenovirus EIB

55K of p53 activity (Yew et al.), 190-202

Discard pathway, role of Ro autoantigen in 5S rRNA production (O'Brien and Wolin), 2891-2903

dishevelled {dsh) gene, Drosophila, role in Wg signaling (Klingensmith et al.), 118-130

DNA binding

activity of TFIIA (Yokomori et al.), 2313-2323

inhibited by POZ domain (Bardwell and Treisman), 1664-1677

to S. pombe MGB elements (Zhu et al.), 885-898


binding protein, sequence-specific, single-stranded FBP activates FUSE of c-myc (Duncan et al.), 465-480

damage growth arrest and DNA damage-in-

ducible gene CHOP (Barone et al.), 453-464

induction by ~/ irradiation, role of p53 (Di Leonardo et al.), 2540- 2551

and mitotic checkpoints (Weinert et al.), 652-665

and replication origin activation (Raghuraman et al.), 554-562

role of SAD1 (Allen et al.), 2401- 2415

imprinting, and new agouti allele A iapy (Michaud et al.), 1463-1472

methylation, of CpG islands (Macleod et al.), 2282-2292

rearrangements, Anabaena heterocyst differentiation (Carrasco et al.), 74-83

recognition, by PPR1 and GAL4 (Mar- morstein and Harrison), 2504- 2512

repair branched DNA structures, impor-

tant intermediates for nucleotide excision repair (Har- rington and Lieber), 1344-1355

role of basal factor TFIIE (Maxon et al.), 515-524

S. cerevisiae of transcriptionally silent chroma-

tin (Paetkau et al.), 2035-2045 RAD6 and RAD18 complex

(Bailly et al.), 811-820 replication

and mitotic checkpoints (Weinert et al.), 652-665

Xenopus, B-globin (Barton and Em- erson), 2453-2465

stability, in HPV16 E7-immortalized HUC cells (Reznikoff et al.), 2227-2240

synthesis, cyclin D1 inhibition of (Pa- gano et al.), 1627-1639

DNA-protein interactions, and specificity of HOX protein function (Zappavigna et al.), 732-744

DNA binding activity

of Drosophila hairy (Ohsako et al.), 2743-2755

inhibition of Su(H) and RBP-JK/KBF2 by H {Brou et al.), 2491-2503

of mi gene (Hemesath et al.), 2770- 2780

of S. cerevisiae RRN6 and RRN7 (Keys et al.), 2349-2362

of TBP (Tansey et al.), 2756-2769 domain

bHLH of E47 (Ellenberger et al.), 970-980

of Drosophila T gene (Kispert et al.), 2137-2150

of Ets (Kraut et al.), 33-44 of rat glucocorticoid receptor (Lefs-

tin et al.), 2842-2856 motif of TEF-1 (Chen et al.), 2293-

2301 of PAX paired domains (Epstein et al.),

2122-2134 properties

bHLH domains of transcription factors (Ellenberger et al.), 970-980

of PPR1 and GAL4 (Marmorstein and Harrison), 2504-2512

protein cut repeats define novel family of bi-

partite DNA-binding proteins (Andr4s et al.), 245-257

Dictyostelium GBF transcription factor (Schnitzler et al.), 502-514

LEF-1, knockout in mice (van Gen- deren et al.), 2691-2703

RORc, isoforms (Gigu4re et al.), 538- 553

DNA-mediated allostery, Of glucocorticoid receptor (Lefstin et al.), 2842-2856

Domain swiveling, DNA-binding domain of HAP1 homodimer (Zhang end Guarente), 2110- 2119

Dominant interfering alleles, define role for c-Myb in T-cell development (Badiani et al.), 770-782

Dominant-negative variants, of activin in fish (Michaud et al.), 1463- 1472

Dominant-negative, allele of Rad51 (Donovan et al.), 2552-2562

Dorsal (dl) morphogen, regulation of by tor and Toll signaling pathways (Rusch and Levine), 1247-1257

Dorsal-ventral axis, ventral cells, Droso- phila sog and dpp (Francois et al.), 2602-2616

Dorsoventral (D/V) patterning. See also Patterning

Drosophila, twisted gastrulation gene (Mason et al.), 1489-1501

polarity, Drosophila oogeneis, speci- fied by Raf (Brand and Perri- mon), 629-639

DORV (double outlet right ventricle), 2792 (Corrigendum)

Dosage compensation, Drosophila male X chromosome, histone acetyla-

tion (Bone et al.), 96-104 sex specificity of (Palmer et al.), 698-

706 Double-strand break repair, role of

Rad51 and Rad52 (Donovan et al.), 2552-2562

dpp, interaction with sog (Francois et al.), 2602-2616

Dr 1 repressor of transcription, interac-

tion with TBP mediates function (Yeung et al.), 2097-2109

Dracl, involved in Drosophila axonal outgrowth and myoblast fusion (Luo et al.), 1787-1802

Drosophila Cut homeo protein {Andr6s e t al.),

245-257 determination of anterior structures

by bicoid (Payre et al.), 2718- 2728

dorsal (d/) morphogen, regulation of by Toll and tot signaling pathways {Rusch and Levine), 1247-1257

dorsal midline fate requires twisted gastrudation gene (Mason et al.), 1489-1501

dosage compensation and histone acetylation (Bone et al.), 96-104

early cell cycle regulation (Edgar et al.), 440-452

embryos, short-range repression in (Gray et al.), 1829-1838

germ-cell specification, role of gcl {lon- gens et al.), 2123-2136

gypsy element has properties of insect retrovirus (Song et al.), 2046- 2057

homeo domain proteins eve and ftz, in vivo DNA binding by (Walter et al.), 1678-1692

imaginal disc, direct downstream targets of proneural activators {Singson et al.), 2058-2071

neurogenesis, repo gene encodes glial- specific homeo domain protein (Xiong et al.), 981-994

oogenesis orb mutations affect polarity (Chris-

terson and McKearin), 614-628 Orb protein and RNA localization

(Lantz et al.), 598-613 pair-rule genes

odd-paired (opa) is expressed in all segments (Benedyk et al.), 105- 117

stripe-specific regulation of, by hopscotch (Binari and Perrimon), 300-312

Raf specifies dorsoventral polarity (Brand and Perrimon), 629-639

regulation of achaete transcription by hairy {Van Doren et al.), 2729- 2742

repression of achaete by hairy (Ohsako et al.), 2743-2755

requirement of PICA for anteroposterior axis development (Lane and Kalderon), 2986-2995

role of sog and dpp in pattern formation in dorsal region (Francois et al.), 2602-2616

role of T and Trg in hindgut specification (Kispert et al.), 2137-2150

segmentation, role of slp (Cadigan et al.), 899-913


sex determination genes snf and Sxl (Flickinger and Salz), 914-925

sex-specific regulation of msl-1 dosage compensation gene (Palmer et al.), 698-706

signal transduction, role of dsh in Wg signaling (Klingensmith et al.), 118-130

Sxl RNA binding and splicing (Wang and Bell), 2072-2085

TFIIF binding, downstream contacts (Purnell et al.), (830-842)

tracheal development, role of breathless (Reichman-Fried et al.), 428-439

transcriptional activation by TFIIA (Yokomori et al.), 2313-2323

trithorax, chromosomal binding (Ku- zin et al.), 2478-2490

Drosophila melanogaster, Doa locus encodes protein kinase essential for eye and embryonic development (Yun et al.), 1160-1173

E

E1A-associated proteins, p300 transcriptional adaptor properties (Eck- net et al.), 869-884

E1B 55K. See also Adenovirus E1B 55K E2 box, binding by escargot protein (Fuse

et al.), 2270-2281 E2F transcription factor, regulation of

linked to cell cycle-dependent activation of kinases (Dynlacht et al.), 1772-1786

E2F-4, interaction with p107 (Ginsberg et al.), 2665-2679, (Beijersber- gen et al..), 2680-2690

E2F1 gene expression, autoregulatory control of during cell cycle progression (Johnson et al.), 1514- 1525

E2F1 promoter, growth regulation of (Hsiao et al.), 1526-1537

E2F family, cloning of E2F-4 (Ginsberg et al.), 2665-2679, (Beijersbergen et al.), 2680-2690

El2, role in activation of IgH enhancer (Weintraub et al.), 2203-2211

E26 avian leukemia virus, Myb-Ets fusion protein (Kraut et al.), 33-44

E47 transcription factor, crystal structure of (Ellenberger et al.), 970- 980

E-box binding of MyoD and El2 (Weintraub

et al.), 2203-2211 consensus sequence, DNA-binding

sites of bHLH proteins (Ellen- berger et al.), 970-980

transcriptional activation by c-myc (Harm et al.), 2441-2452

EBS, role of keratin genes (Rugg et al.), 2563-2573, (Chan et al.), 2574- 2587

EGF receptor, Drosophila (Brand and Perrimon), 629-639

EGF receptor tyrosine kinase, point mutation results in waved-2 phe- notype (Luetteke et al.), 399- 413

Egg chamber, Drosophila oogenesis (Lantz et al.), 598-613

EIIIB exon, of rat fibronectin (FN) gene (Huh and Hynes), 1561-1574

Elk1 activation by RAS/MAP kinase path-

ways (Hipskind et al.), 1803- 1816

ets factor, as relating to new ets member Net (Giovane et al.), 1502- 1513

Elongation factor, SELB (Ringquist et al.), 376-385

Embryogenesis zebrafish pou2, alternatively spliced

twin products of (Takada et ai.), 45-59

Drosophila, early cell cycle regulation (Edgar et al.), 440-452

Embryonic development

in Drosophila controlled by bicoid and serendipity (Payre et al.), 2718-2728

HNF-4 in mouse embryo (Chen et al.), 2466-2477

patterning, RNA localization (Lantz et al.), 598-613

stem (ES) cells GATA-1- and erythroid develop-

ment (Weiss et al.), 1184-1197 gene targeting generated PDGF B-re-

ceptor mutant mice (Soriano), 1888-1896

mice, targeted disruption of Nfl (Brannan et al.), 1019-1029

targeted disruption of Igf2r gene (Lau et al.}, 2953-2963

End formation, RNA 3' (Manley and Proudfoot), 259-264 Meeting Review

Endonucleases. See also Nucleases Endoribonuclease, identification of S.

cerevisiae SNM1 gene product as a component (Schmitt and Clayton), 2617-2628

Endothelial cell growth, mouse embryos, role of Tek RTK (Dumont et al.), 1897-1909

engrailed (en) segment polarity gene, Drosophila (Benedyk et al.), 105-117, (Cadigan et al.), 899- 913

Enhancer activity, and p300 (Eckner et al.), 869-884

Enhancers in B-globin transcription (Barton and

Emerson), 2453-2465 interaction with p300 (Eckner et al.),

869-884

and quenching in Drosophila complex promoters (Gray et al.), 1829- 1838

Epidermal differentiation, C. elegans, role of POU gene ceh-18 (Green- stein et al.), 1935-1948

Epidermolytic hyperkeratosis, role of keratin 14 (Chan et al.), 2574-- 2587

Epithelium, role of keratin 8 gene in development (Baribault et al.), 2964-2973

Epstein-Barr virus, Zta activation domain (Lieberman and Berk), 995-1006

ERK1 human MAP kinase, and C. elegans MAP kinase homolog (Lackner et al.), 160--173

Erythroblastosis, in PDGF B-deficient. mice (Lev6en et al.), 1875-1887

Erythroid development, in vitro differentiation of GATA-1- ES cells (Weiss et al.), 1184-1197

Erythropoiesis, retinoic acid and lymphohematopoietic progenitors (Tsai et al.), 2831-2841

ES cells. See Embryonic stem cells escargot, Drosophila, transcriptional re-

pression (Fuse et al.), 2270-2281 Escherichia coli

mutations in RNase E and RNase P and regulation of mRNA processing (Alifano et al.), 3021- 3031

proteins that stimulate group I splicing (Coetzee et al.), 1575-1588

role of pyrB1 operon in transcriptional initiation (Liu et al.), 2904-2912

SELB translational elongation factor, identification of binding sites and interaction with initiation complex (Ringquist et al.), 376-385

EsT cloning, of human TFIIA (Ozer et al.), 2324-2335

ETS-related proteins, mechanism of activation (Hipskind et al.), 1803- 1816

ets gene family, new member Net encodes transcription factor activated by Ras (Giovane et al.), 1502-1513

Euglena gracilis, chloroplast ycf8 gene, complex twintron within (Hong and Hallick), 1589-1599

even-skipped (eve) gene, Drosophila homeo domain protein, in vivo DNA

binding by (Walter et al.), 1678- 1692

murine evxl homolog of (Spyropoulos and Capecchi), 1949-1961

Evolutionary conservation comparison of human and yeast

TATA-binding proteins (Cot- mack et al.), 1335-1343

cut repeats ('Andr6s et al.), 245-257 human and rat RNA editing of WT1


transcript (Sharma et al.), 720- 731

neurofibromin (Bran_nan et al.), 1019- 1029

Notch gene (Swiatek et al.), 707-719 Ras-mediated signal-transduction path-

ways (Wu and Han), 147-159 evxl murine gene, homolog of Droso-

phila eve gene, role in initiating gastrulation (Spyropoulos and Capecchi), 1949-1961

EWS, and TLS binding to CHOP (Zin- szner et al.), 2513-2526

Expression of Drosophila trithorax and fork head

(Kuzin et al.), 2478-2490 regulation by rare arginine codons

(Chen and Inouye), 2641-2652 Extraceilular signal, produced by As-

pergillus fluG gene (Lee and Ad- ams), 641-651

Eye development human, and PAX6 mutation (Epstein

et al.), 2122-2134 Drosophila Doa locus (Yun et al.),

1160-1173 Eyelid development, mouse, and activin

B/inhibin B {Vassalli et al.), 414-427

F

FAR1 gene, S. cerevisiae, and pheromone treatment (Oehlen and Cross), (1058-1070)

FBP (FUSE-binding protein), sequence- specific, single-stranded DNA- binding protein stimulates c- myc expression (Duncan et al.), 465-480

fdxN gene, Anabaena (Carrasco et al.), 74-83

Female reproduction, mouse, and activin B/inhibin B (Vassalli et al.), 414-427

FEN-l, murine structure-specific endonuclease, related to S. cerevisiae RAD2 family (Harrington and Lieber), 1344-1355

Fetal growth, regulation by Igf2r (Lau et al.), 2953-2963

FGFR-1, required for postimplantation growth and axial organization (Deng et al.), 3045-3057

fgfr-1, requirement for embryonic growth during mouse gastrulation (Yamaguchi et al.), 3032- 3044

fgr src. See src gene family Fibroblastic cells, C/EBP~ promotes adi-

pogenesis (Freytag et al.), 1654- 1663

Fibroblast growth factor (FGF) receptor homolog, breathless, role in

Drosophila tracheal cell migra-

tion (Reichman-Fried et al.), 428--439

signaling role in axial organization (Deng et al.),

3045-3057 of fgfr-1 gene in mesoderm induc-

tion (Yamaguchi et al.), 3032- 3044

Fibroblasts human

G 1 cells, cyclin D1 function (Pagano et al.), 1627-1639,

p21-containing cyclin kinases, active and inactive states (Zhang et al.), 1750-1758

normal human diploid, p53-dependent G1 arrest (Di Leonardo et al.), 2540-2551

normal human (NHF), infected by HPV oncoproteins, differential disruption of genomic integrity (White et al.), 666-677

TGF-[M and tumor progression (Glick et al.), 2429-2440

Fibronectin mRNA, regulation of alternative splicing by hexanucleotide element (Huh and Hynes), 1561-1574

Filamentous fungus, Aspergillus nidulans (Lee and Adams), 641-651

Fission yeast. See Schizosaccharomyces pombe

5S rRNA, processing, binding to Re autoantigen (O'Brien and Wolin), 2891-2903

Flagellar biogenesis, Caulobacter (Win- grove and Gober), 1839-1852

Flower development Arabidosis (Goto and Meyerowitz),

1548-1560 genetic and molecular analyses (Ma),

745-756 Review fluG Aspergillus gene, required for pro-

duction of extracellular developmental signal (Lee and Ad- ams), 641-651

Footprinting, SP1 and CpG islands (Ma- cleod et al.), 2282-2292

fork head, regulation of expression by trithorax (Kuzin et al.), 2478- 2490

forkhead domainl of Drosophila slp proteins (Cadigan et al.), 899-913

fos SRE, SRF binding requires Net (Gio- vane et al.), 1502-1513

FSH[~, regulation by SF-1 (Ingraham et al.), 2302-2312

fugl gene, murine homolog of yeast RNA1 gene (DeGregori et al.), 265-276

Fungal dimorphism, Ustilago maydis (Banuett and Herskowitz), 1367-1378

Fungal life cycle, U. maydis, identification and role of Fuz7 (Banuett and Herskowitz), 1367-1378

FUS1 gene, S. cerevisiae, and pheromone treatment (Oehlen and Cross), (1058-1070)

Fus3 MAP kinase, S. cerevisiae, associates with and phosphorylates Ste5 (Kranz et al.), 313-327

FUSE (far upstream element), of human c-myc proto-oncogene (Duncan et al.), 465--480

fushi tarazu (ftz), Drosophila homeo domain protein, in vivo DNA binding of (Walter et al.), 1678- 1692

Fusion oncoproteins, Myb--Ets (Kraut et al.), 33-44

Fusion protein, S. cerevisiae (Burns et al.), 1087-1105

Fuz7, a Ustilago maydis MEK/MAPKK (Banuett and Herskowitz), 1367-1378

Fyn, tyrosine kinase Src family (Stein et al.), 1999-2007

G

G-box binding factor (GBF), Dictyostel- ium development, switch from early to late development (Schnitzler et al.), 502-514

G 1 cyclins and autoregulatory control of E2F1 ex-

pression (Johnson et al.), 1514- 1525

CLN1 and CLN2, repress mating factor response pathway in yeast (Oehlen and Cross), 1058-1070

functional inactivation of retinoblastoma protein (Hatakeyama et al.), 1758-1771

GABP~ transcription factor, molecular characterization (de la Brousse et al.), 1853-1865

GADD153 gene. See CHOP GAL4 binding sites, fusion with E1B 55K

(Yew et al.), 190-202 GAL4, DNA-binding properties in yeast

(Marmorstein and Harrison), 2504-2512

irradiation, DNA damage, effect of p53 and Cipl (Di Leonardo et al.), 2540-2551

Gastrointestinal tract, role of mk8 in development (Baribault et al.), 2964-2973

Gastrulation mice, role of evxl expression (Spyro-

poulos and Capecchi), 1949- 1961

regulation by Wnt-3a in mouse embryos (Takada et al.), 174-189

role of fgfr-1 gene (Yamaguchi et al.), 3032-

3044 FGFR-1 (Deng et al.), 3045-3057 HNF-4 in development (Chen et al.),

2466-2477


Gene activation, phosphorylation of NF-M

leads to derepression (Kowenz- Leutz et al.), 2781-2791

amplification and HPV oncoproteins (White et al.),

666-677 Tetrahymena rDNA minichromo-

some, blockage by germ-line excision mutation (Kapler and Blackburn), 84-95

expression, light-regulated, Arabidop- sis (Li et al.), 339-349

identification, large-scale screen de- veloped for S. cerevisiae (Burns et al.), 1087-1105

induction, and S. pombe mating pheromone P-factor (Imai and Ya- mamoto), 328-338

knockout, of mk8 gene in mice (Bari- bault et al.), 2964-2973

regulation, mediated by RXR and RAR (Valc~ircel et al.), 3068-3079

targeting absence of fgfr-1 gene and role in

mouse gastrulation (Yamaguchi et al.), 3032-3044

deletion of FGFR- 1 and role in development {Deng et al.), 3045-3057

in ES cells, PDGF f~-receptor mutant mice (Soriano), 1888-1896

of murine PTHrP gene (Karaplis et al.), 277-289

trap identification of TEF-1 gene (Chen

et al.}, 2293-2301 mice (DeGregori et al.), 265-276 mutagenesis, characterization of

murine fugl gene (DeGregori et al.), 265-276

General recombination, S. cerevisiae Sepl protein promotes paranemic joint (Chen et al.), 1356- 1365

Genome stability, human uroepithelial cells (HUG) (Reznikoff et al.), 2227-2240

Genomic imprinting expression of Igf2 and Igf2r in mouse

embryos (Latham et al.), 290-299

role of maternal and paternal genes in fetal growth (Lau et al.), 2953- 2963

Genomic integrity, disruption of by HPV oncoproteins (White et al.), 666-677

Germ-cell specification, Drosophila, role of gcI (Jongens et al.), 2123-2136

Germ-cell-less, Drosophila, role in germ- cell specification pathway (Jon- gens et al.), 2123-2136

Germ line development, C. elegans, role of POU

gene ceh-18 (Greenstein et al.), 1935-1948

excision mutation (rmmll/6), Tetra- hyrnena thermophila, amplification blockage (Kapler and Blackburn), 84-95

GL2. See GLABRA2 GLABRA2 (GL2) homeo box gene, role

in trichome development in Ar- abidopsis (Rerie et al.), 1388- 1399

Glial cells, Drosophila, repo gene encodes glial-specific homeo domain protein (Xiong et al.), 981- 994

Glomerulus development, in PDGF B-deficient mice (Lev6en et al.), 1875-1887

Glucocorticoid receptor, DNA binding, transcriptional activation (Lefs- tin et al.), 2842-2856

Gonad migration, C. elegans, role of POU gene ceh-18 (Greenstein et al.), 1935-1948

Gonadal development, regulation by SF-1 (Ingraham et al.), 2302- 2312

Gonadotrope-specific markers, regulation by SF-1 (Ingraham et al.), 2302-2312

Group I introns bacteriophage T4, self-splicing proper-

ties (Coetzee et al.), 1575-1588 Tetrahymena (Downs and Cech),

1198-1211 Group III intron evolution, (Hong and

Hallick), 1589-1599 Growth

inhibition, role of c-myc overexpres- sion (Harm et al.), 2441-2452

regulation, of E2F1 promoter (Hsiao et al.), 1526-1537

GTPases, distinct morphogenetic function of (Luo et al.), 1787-1802

Gut, role of keratin 8 gene in development (Baribault et al.), 2964- 2973

Gynogenone, and genomic imprinting (Latham et al.), 290-299

gypsy element, Drosophila, properties of insect retrovirus (Song et al.), 2046-2057

H

H19 RNA, association with imprinting (Pfeifer and Tilghman), 1867- 1874 Commentary

H. See Hairless (Brou et al.), 2491-2503 Hf~58 mouse gene, yeast homolog of

(Bachhawat et al.), 1379-1387 Hair follicle development, mice EGFR

activity {Luetteke et al.), 399-413

Hairless, interaction with Su(H) (Brou et al.), 2491-2503

hairy, transcriptional repressor of achaete (Van Doren et al.), 2729-

2742, (Ohsako et al.), 2743- 2755

HAP1 transcriptional activator, yeast, DNA-binding domain (Zhang and Guarente), 2110-2119

hck src. See src gene family Helix-loop--helix proteins

Drosophila achaete (ac) and scute (sc) {Singson et al.), 2058-2071

encoded by Xenopus achaete-scute homologs (Turner and Weintraub), 1434-1447

Id-2, growth enhancement and pRb binding by (Iavarone et al.), 1270-1284

Hematological disorders, in PDGF B-receptor mutant mice (Soriano), 1888-1-896

Hematopoiesis in bmi-1 mutant mice (van der Lugt et

al.}, 757-769 mouse ES cells (Weiss et al.), 1184-

1197 role of retinoic acid receptors (Tsai et

al.), 2831-2841 Hematopoietic stem cells, lineage com-

mitment (Kraut et al.), 33-44 Heterocyst differentiation, Anabaena,

DNA rearrangement during (Carrasco et al.), 74-83

Heterodimer, of RXR and RAR regulates retinoid-dependent transcription (Valc~ircel et al.), 3068- 3079

Hexanucleotide element, regulation of fibronectin mRNA alternative splicing (Huh and Hynes), 1561-1574

Hindgut specification, Drosophila, role of Brachyury (T) gene (Kispert et al.), 2137-2150

his operon, role of RNase E and RNase P in mRNA processing (Alifano et al.), 3021-3031

Histone acetylation, Drosophila male X chro-

mosome, dosage compensation (Bone et al.), 96-104

H1, Xenopus, in vivo regulation of chromomosomal 5S rRNA gene transcription (Bouvet et al.), 1147-1159

HIV-1, Rev trans-activator, nuclear export of (Meyer and Malim), 1538-1547

HLH, hairy a transcriptional repressor of achaete

(Ohsako et al.), 2743-2755 repressor of Drosophila achaete (Van

Doren et al.), 2729-2742 HNF, cell death in mouse embryo (Chen

et al.), 2466-2477..- hnRNP, binding to TLS and EWS (Zin-

szner et al.), 2513-2526 Homeo box gene, GLABRA2 (GL2), role

in normal trichome develop-


ment in Arabidopsis (Rerie et al.), 1388-1399

Homeo box-containing (HOX) genes, transcription of (Zappavigna et al.), 732-744

Homeo domain of c~2 interacts with WD repeats (Ko-

machi et al.), 2857-2867 of Cut and Cut-like proteins (Andrds

et al.), 245-257 of HOX proteins (Zappavigna et al.),

732-744 proteins

Drosophila even-skipped (eve) and fushi tarazu (ftz), DNA targets of (Walter et al.), 1678-1692

Drosophila, repo gene encodes glial- specific protein (Xiong et al.), 981-994

encoded by GLABRA2 gene, role in normal trichome development in Arabidopsis (Rerie et al.), 1388-1399

Homeotic gene Arabidopsis PISTILLATA (PI) gene

(Goto and Meyerowitz), 1548- 1560

fork head, regulation of expression by trithorax (Kuzin et al.), 2478- 2490

Homodimers, HAP1, asymetric binding (Zhang end Guarente), 2110-2119

Homologous pairing, S. cerevisiae Sepl protein promotes a paranemic joint (Chen et al.), 1356-1365

Homologous recombination recombination hot spots (Wahls and

Smith), 1693-1702 and reverse mutations in mouse agouti

locus (Bultman et al.), 481-490 and S. pombe rec mutants (De Veaux

and Smith), 203-210 hopscotch (hop)gene, Drosophila, stripe-

specific regulation of pair-rule genes (Binari and Perrimon), 300-312

HOX protein function, specificity of de- pends on DNA-protein and protein-protein interactions (Zap- pavigna et al.), 732-744

HPV16 E6/E7, role in senescence and genome stability (Reznikoff et al.), 2227-2240

HPV oncoproteins, infection of normal human fibroblasts, differential disruption of genomic integrity (White et al.), 666-677

HPV-16 E7, expression in transgenic mice, role of p53 (Howes et al.), 1300-1310

hrp48 factor, interaction with Droso- phila PSI (Siebel et al.), 1713- 1725

hsp70 promoter, Drosophila, interaction with TFIID (Purnell et al.), (830-842)

hTAFII250 , binding to TBP (Tansey et al.), 2756-2769

HUC, human uroepithelial cells, immortalization by HPV16 (Reznikoff et al.), 2227-2240

Hypermethylation, of U8 RNA (Peculis and Steitz), 2241-2255

Hypersensitive site, murine IgH locus, regulation by c-myc expression (Madisen and Groudine), 2212- 2226

I

Id-2 helix-loop-helix protein, growth enhancement and pRb binding by (Iavarone et al.), 1270-1284

Igf2 and Igf2r imprinted genes, inactivation occurs postfertilization (Latham et al.), 290-299

IGF2, regulation of fetal growth and heart development (Lau et al.), 2953-2963

Igf2r, insulin-like growth factor II/cation- independent mannose 6-phos- phate receptor, role in fetal growth (Lau et al.), 2953-2963

IgH cis-acting negative element directed at

MyoD (Weintraub et al.), 2203- 2211

transcription, DNase I hypersensitive sites (Madisen and Groudine), 2212-2226

Imaginal disc Drosophila, direct downstream targets

of proneural activators (Singson et al.), 2058-2071

Drosophila escargot (Fuse et al.), 2270--2281

Immortalization, of lymphohematopoietic progenitors by retinoic acid receptors (Tsai et al.), 2831- 2841

Immune response, mice, targeted disruption of src genes, hck and fgr, impairs immunity (Lowell et al.), 387-398

Immunoglobulin antigen receptor, regulatory role of

components in B-cell development (Spanopoulou et al.), 1030-1042

gene rearrangement, v-abl suppresses light-chain rearrangement (Chen et al.), 688-697

HC and LC expression, influence on B-cell differentiation (Young et al.), (1043-1057)

transgenes, HC and LC, introduction into RAG-2-deficient mice (Young et al.), (1043-1057)

Immunoglobulin-CAM family, mem- brane-bound protein encoded by human DCC gene (Hedrick et al.), 1174-1183

Immunohistochemistry, analysis of human DCC gene product (He- drick et al.), 1174-1183

Imprinting. See also Genomic imprinting (Binari and Perrimon), 300- 312

association with X chromosome inactivation (Pfeifer and Tilghman), 1867-1874 Commentary

In vitro differentiation, of GATA-1- ES cells

(Weiss et al.), 1184-1197 transcription, of E2F transcription fac-

tor (Dynlacht et al.), 1772-1786 UV cross-linking, Drosophila, mea-

sure DNA targets of homeo domain proteins (Walter et al.), 1678-1692

Influenza virus NS1 protein, inhibition of pre-mRNA splicing (Lu et al.), 1817-1828

Inh, interaction with Tn5 (Weinreich et al.), 2363-2374

Inhibitor, p27 Kip1 cyclin-CDK inhibitor, role in cell cycle arrest (Polyak et al.), 9-22

Initiator element (Inr), core promoter element,

recognition of Inr by TFIID (Kaufmann and Smale), 821-829

within Drosophila class II gene promoters, TFIID sequence recognition of (Purnell et al.), (830- 842)

Insect retrovirus, Drosophila gypsy element (Song et al.), 2046-2057

Insertional mutagenesis, gene trap mutagenesis (DeGregori et al.), 265-276

Insulin-like growth factor II, required for regulating normal fetal growth (Lau et al.), 2953-2963

Integration targets, retrovirus integration (Withers-Ward et al.), 1473-1487

Interleukin- 1 [~-converting enzyme, mammalian, mouse Nedd2 gene encodes protein similar to (Kumar et al.), 1613-1626

Intermediate filaments, involvement in EBS (Rugg et al.), 2563-2573, (Chan et al.), 2574-2587

Intracisternal A-particle yellow {Aiapy), dominant agouti allele (Mi- chaud et al.), 1463-1472

Introns, plants vs. yeast and animals (Luehrsen and Walbot), 1117- 1130

JNK, role in transcriptional activation of c-Jun (Kallunki et al.), 2996- 3007

JNK2, binding and phosphorylation of c- Jun (Kallunki et al.), 2996-3007


K

K14. See Keratin (Rugg et al.), 2563- 2573, (Chan et al.), 2574-2587

K gene transcription, blocked by v-abl viral transforming protein (Klug et al.), 678=687

KBF2, derived from RBP-JK gene (Brou et al.), 2491-2503

Keratin, human knockout (Rugg et al.), 2563-2573, (Chan et al.), 2574- 2587

Keratin 8, disruption causes colorectal hyperplasia (Baribault et al.), 2964-2973

Keratinocytes, TGF-f31 and tumor progression (Glick et al.), 2429- 2440

Kidney development, abnormalities in PDGF ~-receptor mutant mice (Soriano), 1888-1896

Kidney malignancies, Wilms' tumor susceptibility gene (WT1) (Sharma et al.), 720-731

Kinases, mice, functional overlap in the src gene family (Lowell et al.), 387-398

Kluyveromyces lactis cloning of BRF homolog (Khoo et al.),

2879-2890 RadS1 homolog (Don6van et al.),

2552-2562 Knockout, of LEF-1 in mice (van Gen-

deren et al.), 2691-2703

L

lac promoter, mutations defining activation target (Tang et al.), 3058- 3067

LAMMER protein kinases, new Droso- phila protein kinase family, encoded by Doa locus, (Yun et al.), 1160-1173

Lateral inhibitory signaling, Drosophila imaginal disc (Singson et al.), 2058-2071

LCR, role of IgH hypersensitive sites (Madisen and Groudine), 2212- 2226

LEF-1, organ development in mice (van Genderen et al.), 2691-2703

Lens development, mice, implications for tumor suppressor gene function (Pan and Griep}, 1285-1299

Leucine zipper of C/EBP~, novel function of in cell-

type-specific gene expression (Nerlov and Ziff), 350-362

of CHOP, role in transformation (Zin- szner et al.), 2513-2526

proteins, C/EBPe~ promotes adipogenesis (Freytag et al.), 1654-1663

S. cerevisiae SNM1 (Schmitt and Clay- ton), 2617-2628

Leukemogenesis, by fusion oncoproteins (Kraut et al.), 33-44

LH~, regulation by SF-1 (Ingraham et al.), 2302-2312

Light response, link with multicellular development in M. xanthus (Nicol~is et al.), 2375-2387

Lineage commitment, of hematopoietic stem cells (Kraut et al.), 33-44

LMPCR, CpG islands and methylation (Macleod et al.), 2282-2292

Locusta (Kispert et al.), 2137-2150 Lymphohematopoietic progenitors, reti-

noic acid and immortalization (Tsai et al.), 2831-2841

Lymphoid cells, Abelson routine leukemia virus transformation of (Chen et al.), 688-697

Lymphoid enhancer factor 1. See LEF-1 (van Genderen et al.), 2691- 2703

Lysosome, delivery of proteins to (Bach- hawat et al.), 1379-1387

M

M box, transcriptional activation by mi (Hemesath et al.), 2770-2780

M-CAT, binding factor, identity with TEF-1 (Ghen et al.), 2293-2301

Macrophages, mice, effects of hck and fgr deficiences (Lowell et al.), 387- 398

MADS box gene family, Arabidopsis PI is member of (Goto and Mey- erowitz), 1548-1560

Maize, splicing and polyadenylation, role of AU-rich motifs (Lue- hrsen and Walbot), 1117-1130

Male-specific lethal- 1 (msl-1) Drosophila gene, dosage compensation gene, sex-specific regulation of (Palmer et al.), 698-706

Mammary tumorigenesis, induced by PyV middle T antigen, c-Src required for (Guy et al.), 23-32

MAP kinase cascade

in Drosophila (Hsu and Perrimon), 2176-2187

role in spore formation (Friesen et al.), 2162-2175

homolog C. elegans mpk-1, role in vulval de-

velopment (Lackner et al.), 160- 173

encoded by C. elegans sur-1 gene, role in vulval signal transduction pathway (Wu and Hart), 147-159

S. cerevisiae SMK1 (Krisak et al.), 2151-2161

role ill activation of ternary complex fac-

tors (Hipskind et al.), 1803-1816

of JNK2 in phosphorylation of c-Jun (Kallunki et al.), 2996-3007

in mating and invasive growth in S. cerevisiae (Roberts and Fink}, 2974-2985

S. cerevisae Fus3, association with signaling component Ste5 (Kranz et al.), 313-327

Maternal mRNAs, regulation of polyadenylation (Sheets et al.), 926-938

Maternally expressed gene, zebrafish pou2 (Takada et al.), 45-59

Mating factor response pathway, G 1 cyclin repression of in yeast (Oehlen and Cross), 1058-1070

Mating pheromone P-factor, S. pombe (Imai and Yamamoto), 328-338

Mating type identity, yeast, role of SSN6 and TUP1 (Cooper et al.), 1400- 1410

Mating-type loci, regulation by SIR3 and RAP1 (Moretti et al.), 2257- 2269

Max, binding to c-myc (Harm et al.), 2441-2452

MCB elements, S. pombe cell division regulation (Zhu et al.), 885-898

mClox protein, mammalian counterpart of Drosophila Cut homeo protein (Andrds et al.), 245-257

MCM1, yeast c, cells (Cooper et al.), 1400-1410

mdm2 proto-oncogene, regulation of expression by p53 (Barak et al.), 1739-1749

mdm-2, binding to amino terminus of p53 (Linet al.), 1235-1246

Medaka fish, dominant-negative activin variants in (Michaud et al.), 1463-1472

MEF2 protein. See RSRF protein Meiosis

gene expression, transcriptional regulator UME6 (Strich et al.), 796- 810

S. pombe and pet1 + gene (Zhu et al.), 885-898

Meiotic recombination -deficient (rec) mutants, S. pombe (De

Veaux and Smith), 203-210 hot spot activity (Wahls and Smith),

1693-1702 region-specific activators in S. pombe

(De Veaux and Smith), 203-210 MEK, Drosophila signal transduction

(Hsu and Perrimon), 2176-2187 Melanocyte development, regulation by

mi (Hemesath et al.}, 2770-2780 Mesengial cells, absence of in PDGF

B-deficient mice (Lev4en et al.}, 1875-1887

Mesoderm formation, and Wnt signaling (Takada

et al.), 174-189 induction, role of

activin (Michaud et al:), 1463-1472


fgfr-1 gene (Yamaguchi et al.), 3032- 3044

FGFR-1 (Deng et al.), 3045-3057 Mesodermalizing activity, of Xenopus

Brachyury gene (Xbra) (Rao), 939-947

Metastasis, mammary tumorigenesis, c-Src requirement (Guy et al.), 23-32

Metazoan splicing factor U2AF65, yeast gene MUD2 has sequence similarity to (Abovich et al.), 843- 854

Methylation and genomic imprinting (Latham et

al.), 290-299 role in differential expression of A i~py

mutation (Michaud et al.), 1463-1472

MFA2 mRNA, 5' --~ 3' decay (Muhrad et al.), 855-866

microphthalmia, a critical factor in melanocyte development (Heme- sath et al.), 2770-2780

MiT family, role in melanocyte development (Hemesath et al.), 2770- 2780

Mitosis (late), Sdb25 function leads to down-regulation of Cdc28 kinase activity (Donovan et al.), 1640-1653

Mitosis, early cell cycle regulation in Drosophila (Edgar et al.), 440- 452

Mitotic asynchrony, pole bud nuclei (Jongens

et al.), 2123-2136 checkpoint genes, budding yeast

(Weinert et al.), 652-665 MKS, mouse keratin 8 gene (Baribault et

al.), 2964-2973 Morphogenesis

C-factor, M. xanthus (Sager and Kai- ser), 2793-2804

cAMP and U. maydis (Gold et al.), 2805-2816

Morphogens, Drosophila dorsal (d/), regulation of by tor and Toll signaling pathways (Rusch and Levine), 1247-1257

Motl global repressor, inhibits TBP binding (Auble et al.), 1920-1934

Mouse activin B/inhibin B disruptions, eyelid

development and female reproduction (Vassalli et al.), 414-427

agouti transcripts (Bultman et al.), 481-490

apoptosis, induction of by Nedd2 (Ku- mar et al.), 1613-1626

Brachyury gene, Xenopus homolog of (Xbra) (Rao), 939-947

development fugl gene required for postimplanta-

tion development (DeGregori et al.), 265-276

LEF-1 knockout (van Genderen et al.), 2691-2703

role of Notchl in postimplantation development (Swiatek et al.), 707-719

developmental defects in bmi-1 mutants (van der Lugt et al.), 757- 769

RAG-2 deficient, introduction of immunoglobulin transgenes into (Young et al.), (1043-1057)

embryonic stem (ES) cells, GATA-1- and erythroid development (Weiss et al.), 1184-1197

embryos gastrulation, regulation by Wnt-3a

(T~akada et al.), 174-189 Igf2 and Igf2r expression, genomic

imprinting and inactivation are separate processes (Latham et al.), 290-299

role of Tek RTK in vasculogenesis (Dumont et al.), 1897-1909

genes, H1358, yeast homolog of (Bach- hawat et al.),~1379-1387

HNF-4 and gastrulation (Chen et al.), 2466-2477

PDGF B mutants have renal, cardiovascular, and hematological abnormalities (Lev6en et al.), 1875-1887

PDGF f3-receptor mutants (Soriano), 1888-1896

Src family of tyrosine kinases (Stein et al.), 1999-2007

inactivation of src-like genes hck and fgr impairs natural immunity (Lowell et al.), 387-398

yeast RNA1 homolog fugl required for postimplantation development (DeGregori et al.), 265-276

mpk-1, C. elegans MAP kinase homolog, role in vulval induction (Lack- net et al.), 160-173

mPPAR~/2 (murine PPAR), adipocyte- specific transcription factor (Tontonoz et al.), 1224-1234

Murine genes, FEN-1 encodes structure-spe-

cific endonuclease (Harrington and Lieber), 1344-1355

lens morphogenesis, role of tumor suppressor gene products (Pan and Griep), 1285-1299

mRNA degradation, MFA2 mRNA, deadenyla-

tion followed by decapping and 5 ' ~ 3' digestion (Muhlrad et al.), 855-866

expression, XMyoD in Xenopus embryos (Rupp et al.), 1311-1323

localization, and Drosophila orb gene (Christerson and McKearin), 614-628

processing, role of RNase E and RNase P (Alifano et al.), 3021-3031

stability, influence of papl-1 mutants (Proweller and Butler), 2629" 2640

ms1 genes, Drosophila (Bone et al.), 96- 104

MTS2, C D K 4 - a n d CDK6-interacting protein (Guan et al.), 2939- 2952

Mu requirement for four active monomers

(Baker et al.), 2416-2428 transposase, promotion of transposi-

tion (Baker et al.), 2416-2428 MUD2 yeast protein, functional similar-

ity to metazoan splicing factor U2AF65 (Abovich et al.), 843- 854

Multicellular development, in M. xanthus (Nicol~is et al.), 2375-2387

Multimer formation, basis for Tn5 cis preference (Weinreich et al.), 2363-2374

Multipotent progenitor cells (MEPs), transformation and proliferation (Kraut et al.), 33-44

Muscle development. See also Myogenesis morphogenesis, Drosophila Dracl in-

volved in myoblast fusion (Luo et al.), 1787-1802

Myc, role of p53 in apoptosis (Wagner et al.), 2817-2830

Myelopoiesis, role of retinoic acid receptors (Tsai et al.), 2831-2841

Myoblast fusion, involvement of Droso- phila Dracl (Luo et al.), 1787- 1802

MyoD activation of myogenic genes (Wein-

traub et al.), 2203-2211 activity, negative regulation of (Rupp

et al.), 1311-1323 Myogenesis

bHLH factors (Olson and Klein), 1-8 Review

MyoD activity in Xenopus embryos (Rupp et al.), 1311-1323

Myogenic gene, activation by MyoD (Weintraub et al.), 2203-2211

Myosin light-chain gene, Xenopus embryo, regulated by SL1 protein (Chambers et al.), 1324-1334

Myxobacteria, light response and multicellular development (Nicol~is et al.), 2375-2387

Myxococcus xanthus role of C-factor in wave pattern (Sager

and Kaiser), 2793-2804 link between light response and mul-

ticellular development (Nicol~is et al.), 2375-2387

Myxoid liposarcoma human, presence of TLS-CHOP (Bar-

one et al.), 453-464 role of CHOP and TLS (Zinszner et

al.), 2513-2526


N

N-ras oncogene, transformation of transcription factor AP-2 (Kannan et al.), 1258-1269

Natural scrapie, and Prp codon in sheep (Westaway et al.), 959-969

Negative regulation of XMyoD activity (Rupp et al.), 1311-

1323 by yeast NOT complex (Collart and

Struhl), 525-537 Negative selection, of B cells {Spanopou-

lou et al.), 1030-1042 Neural crest

LEF-1 and development (van Genderen et al.), 2691-2703

tissues derived from, 1019-1029 Neural development

mammalian, and Wnt-3a (Takada et al.), 174-189

regulation by C. elegans unc-51 (Ogura et al.), 2389-2400

Neuralizing activity, of Xenopus Brachyury mutant (Rao), 939- 947

Neurofibromatosis type 1 (NF1), targeted disruption of gene, mouse model system (Brannan et al.), 1019-1029, 2792 Corrigendum

Neurogenesis control by hairy and achaete (Van

Doren et al.), 2729-2742 Drosophila

imaginal disc (Singson et al.), 2058- 2071

repo gene encodes glial-specific homeo domain protein (Xiong et al.), 981-994

in Xenopus and achaete-scute homologs (Turner and Weintraub), 1434-1447

Neuronal differentiation, role of RB protein (Lee

et al.), 2008-2021 morphogenesis, Drosophila Dracl in-

volved in axonal outgrowth (Luo et al.), 1787-1802

NF-KB/Rel factors, negatively regulated by v-abl tyrosine kinase (Klug et al.), 678-687

NF-M, homolog of C/EBP~ (Kowenz- Leutz et al.), 2781-2791

Nitrogen fixation, Anabaena heterocys- tous cyanobacterium (Carrasco et al.), 74-83

Nitrogen-signaling systems, and early meiotic gene expression (Strich et al.), 796-810

Non-AUG initiation, of c-myc activates transcription of C/EBP (Hann et al.), 2441-2452

NOT proteins, S. cerevisiae, inhibition of RNA polymerase II machinery (Collart and Struhl), 525- 537

Notochord, development and role of fgfr-1 gene (Yamaguchi et al.), 3032-3044

Nuclear export. See also Nucleocytoplasmic

transport intron evolution, (Hong and Hallick),

1589-1599 localization, of XMyoD (Rupp et al.),

1311-1323 polyadenylation factors, polyadenyla-

tion specificity factor (CPSF) and poly(A) polymerase (PAP) (Bilger et al.), 1106-1116

pores, of Drosophila pole cells (Jon- gens et al.), 2123-2136

receptor, SF-1, role in reproduction (In- graham et al.), 2302-2312

receptors (RORet family), DNA-binding activity of (Gigudre et al.), 538-553

Nucleases, structure-specific endonucleases, murine FEN-1 related to S. cerevisiae RAD2 (Har- rington and Lieber), 1344-1355

Nucleocytoplasmic transport, HIV-1 Rev protein (Meyer and Malim), 1538-1547

Nucleolar snRNP, function in Xenopus oocytes (Peculis and Steitz), 2241-2255

Nucleophile selection, nuclear pre- mRNA splicing (Query et al.), 587-597

Nucleotide excision repair, structure- specific endonucleases FEN-1 and RAD2 are related (Har- rington and Lieber), 1344-1355

O

Oct-3 transcription factor, murine, zebrafish pou2 related to (Takada et al.), 45-59

Oncogenes myc-mediated apoptosis (Wagner et

al.), 2817-2830 N-ras modulates transcription factor

AP-2 (Kannan et al.), 1258-1269 polyomavirus (PyV) middle T onco-

gene (Guy et al.), 23-32 ras (Giovane et al.), 1502-1513 role in derepression of NF-M (Kowenz-

Leutz et al.), 2781-2791 Oocyte

cell cycle arrest, C. elegans, role of POU gene ceh-18 (Greenstein et al.), 1935-1948

maturation, translational activation of mRNAs (Sheets et al.), 926-938

Oogenesis Drosophila, Orb protein and RNA lo-

calization (Lantz et al.), 598- 613

role of PKA in Drosophila develop-

ment (Lane and Kalderon), 2986--2995

orb gene, Drosophila oogenesis, required for A/P and D/V patterning (Christerson and McKearin), 614-628

Orb protein, and RNA localization in Drosophila oogenesis (Lantz et al.), 598-613

Organogenesis, affected by LEF-1 knockout in mice (van Genderen et al.), 2691-2703

oskar regulation by PKA in Drosophila oocytes (Lane and Kalderon), 2986-2995

Osmotically regulated genes, Escherich- ia coli, regulation by ¢s factor (Lange and Hengge-Aronis), 1600-1612

Osteochondrodysplasias, human, poten- tial involvement of PTHrP (Ka- raplis et al.), 277-289

P

p18, CDK6-interacting protein (Guan et al.), 2939-2952

p21-containing cyclin kinases, active and inactive states of (Zhang et al.), 1750-1758

P22 repressor dimer, specificity determinants for dimer-dimer interactions (Whipple et al.), 1212- 1223

p27 Kip1 cyclin-Cdk inhibitor, role in cell cycle arrest (Polyak et al.), 9-22

P40 sDB2s, putative CDK inhibitor involved in S. cerevisiae M/G1 transition {Donovan et al.), 1640-1653

p53 binding to HPV16 E6 (Reznikoff et al.),

2227-2240 cell cycle arrest and induction of Cip 1

(Di Leonardo et al.), 2540-2551 gene, checkpoint function of (White et

al.), 666--677 oncoprotein expression, role in mouse

lens development (Pan and Griep}, 1285-1299

protein, mapping the amino-terminal functions (Lin et al.), 1235-1246

required for myc-mediated apoptosis (Wagner et al.), 2817-2830

transcription factor, direct repression by adenovirus E1B 55K (Yew et al.), 190-202

tumor suppressor gene, regulation of mdm2 expression (Barak et al.), 1739-1749

tumor suppressor protein regulates expression of the p21 gene

(Zhang et al.), 1750-1758 subtle role in regulation of normal

cell growth (Zhang et al.), 1750- 1758


p107 association with E2F-4 (Beijersbergen

et al.), 2680-2690 binding to E2F-4 (Ginsberg et al.),

2665-2679 p300, 300-kD E1A-associated protein

with transcriptional adaptor properties (Eckner et al.), 869- 884

P element Drosophila, splicing of IVS3 (Siebel et

al.), 1713-1725 somatic inhibitor. See PSI

P-factor mating pheromone, S. pombe fission yeast (Imai and Ya- mamoto), 328-338

Pair-rule genes, Drosophila odd-paired (opa), expressed in all seg-

ments (Benedyk et al.), 105-117 stripe-specific regulation of by tyro-

sine kinase gene hop (Binari and Perrimon), 300-312

Paired domain, Pax (paired box) family transcription factors (Epstein et al.), 2022-2134

papl, effect on translation in S. cerevisiae (Proweller and Butler), 2629-2640

Papillomaviral oncogenes, HPV-16 E6 and E7, inhibition of p53 and Rb (Pan and Griep), 1285-1299

Paranemic joint, and S. cerevisiae Sepl strand exchange protein {Chen et al.), 1356-1365

Parathyroid hormone-related peptide (PTHrP), role in normal skeletal development (Karaplis et al.), 277-289

Parathyroid hormone-related peptide gene, role in skeletal development (Karaplis et al.), 277-289

Particle assembly, in Xenopus oocytes (Peculis and Steitz), 2241-2255

Pattern formation. See also Pair-rule genes

Drosophila pair-rule gene expression (Binari

and Perrimon), 300-312 segment polarity genes (Cadigan et

al.), 899-913 late Dictyostelium development, reg-

ulated by cAMP receptor CAR4 (Louis et al.), 2086-2096

of primitive streak regulated by FGFR-1 {Deng et al.), 3045-3057

role of Drosophila sog and dpp (Frangois et

al.), 2602-2616 dsh in wg-mediated events (Klingen-

smith et al.), 118-130 orb gene (Christerson and McK-

earin), 614-628. Pax (paired box) transcription factors, al-

ternative binding b y subdomains (Epstein et al.), 2022- 2134

PCNA (proliferating cell nuclear antigen), and DNA repair (Pagano et al.), 1627-1639

pctl + gene, required for meiosis in S. pombe (Zhu et al.), 885-898

PDGF B. See Platelet-derived growth factor B

PEP8 yeast gene, homolog of mouse H~58 gene {Bachhawat et al.), 1379-1387

Peripheral nervous system, pattern formation regulated by hairy and achaete (Van Doren et al.), 2729-2742

Peroxisome proliferator-activated receptor (PPAR), routine PPAR (mPPAR72) (Tontonoz et al.), 1224-1234

Phage k, specificity determinants for dimer-dimer interactions (Whip- ple et al.), 1212-1223

Pheromone signaling, yeast cell cycle (Oehlen and Cross), (1058-1070)

Phosphoribosyltransferase {aprt), methylation of CpG islands (Macleod et al.), 2282-2292

Phosphorylation of c-Jun by JNK2 (Kallunki et al.),

2996-3007 of E2F by cyclin-kinase compexes

{Dynlacht et al.), 1772-1786 of E2F-4 during the cell cycle (Gins-

berg et al.), 2665-2679 of NF-M induces activation via dere-

pression (Kowenz-Leutz et al.), 2781-2791

of retinoblastoma protein, cyclin regulated (Hatakeyama et al.), 1758- 1771

of SpoIIAA by SpoIIAB (Diederich et al.), 2653-2663

Photo-cross-linking, of branch-site associated proteins (MacMillan et al.), 3008-3020

Photomorphogenesis. See also Pho- totransduction pathway

Photoreceptors, inactivation of pRB in (Howes et al.), 1300-1310

Phototransduction pathway, Arabidop- sis (Li et al.), 339-349

Phylogeny, common secondary structure of telomerase RNAs (Lingner et al.), 1984-1998

Phytochrome, signal transduction (Bowl- er et al.), 2188-2202

Pigmentation, mouse agouti locus (Bult- man et al.), 48t--490

Plant pathogen, basidiomycete fungus Ustilago maydis (Banuett and Herskowitz), 1367-1378

Plasmacytoma, murine, c-myc and IgH locus (Madisen and Groudine), 2212-2226

Plasmids, origin activity on cut and un- cut plasmids (Raghuraman et al.), 554-562

Platelet-derived growth factor (PDGF) a-receptor (Soriano), 1888-1896 l~-receptor mutant mice (Soriano),

1888-1896 B (PDGF B) defiency, mutant mice

show renal, cardiovascular and hematological abnormalities (Le- v6en et al.), 1875-1887

Polarity, Drosophila oogenesis (Brand and Perrimon), 629-639

Orb protein and RNA localization {Lantz et al.), 598-613

role of orb gene (Christerson and McKearin), 614-628

Poliovirus, RNA replication coupled to translation (Novak and Kirkeg- aard), 1726-1737

Poly(A) -deficient cells, efficient translation in

S. cerevisiae (Proweller and But- ler), 2629-2640

mRNA, inhibition of nuclear export by NS1 protein (Lu et al.), 1817- 1828

polymerase {PAP, and cytoplasmic polyadenylation (Bilger et al.), 1106-1116

Polyadenylation coupling of intron removal and 3'-end

formation (Nesic and Maquat), 363-375

CPSF and PAP recognize cytoplasmic polyadenylation elements (Bil- ger et al.), 1106-1116

maize, directed by AU-fich motifs (Luehr- sen and Walbot), 1117-1130

as related to trans-splicing (Matthews et al.), 491-501

role of snRNP-A protein in (Lutz and Alwine), 576-586

in S. cerevisiae (Proweller and Butler), 2629-2640

3' end formation and function {Manley and Proudfoot), 259-264 Meet- ing Review

and translation of cyclin and c-mos mRNAs (Sheets et al.), 926-938

Polycomb, interaction with trithorax (Kuzin et al.), 2478-2490

Polycomb group (Pc-G), functional conservation of mammalian homolog (van der Lugt et al.), 757- 769

Polyomavirus (PyV) middle T antigen, and induction of mammary tumorigenesis, c-Src required (Guy et al.), 23-32

POP1 gene, S. cerevisiae, encodes protein component common to RNase MRP and RNase P (Lygerou et al.), 1423-1433

Position effect. See also Telomeric position effect

Position-effect variegation, yeast genes located near telomeres (Apari- cio and Gottschling), 1133-1146


Positive regulation, of pre-mRNA splicing (Tian and Maniatis), 1703- 1712

Post-transcriptional regulation, of E. coli rpoS/cr S expression (Lange and Hengge-Aronis), 1600-1612

Postimplantation development, mice, role of Notchl (Swiatek et al.), 707-719

Postimplantation mouse development, fugl gene, murine homolog of yeast RNA1 gene (DeGregori et al.), 265-276

Potassium permanganate (KMNO4), modification of unpaired bases (Duncan et al.), 465-480

POU domain gene, zebrafish pou2, alterna-

q . Uvely spliced (Takada et al.), 45-59

homeo box gene, C. elegans ceh-18 gene, targeted mutation ins (Greenstein et al.), 1935-1948

POZ domain, conserved protein-protein interaction domain (Bardwell and Treisman), 1664-1677

PPR1 DNA-binding properties in yeast (Mar-

morstein and Harrison), 2504- 2512

trans-activator, yeast, overcomes telomeric silencing in cell cycle-dependent manner (Aparicio and Gottschling), 1133-1146

pRb alteration by HPV16 E7 (Reznikoff et

al.), 2227-2240 requirement for growth suppression

induced by p18 or p16 (Guan et al.), 2939-2952

pre-B lymphocytes, v-abl inhibits K locus transcription (Klug et al.), 678- 687

Pre-mRNA splicing branch nucleophile selection (Query et

al.), 587-597 inhibition by influenza virus NS1 pro-

tein {Lu et al.), 1817-1828 positive regulation of (Tian and Mani-

atis), 1703-1712 regulation of requires PSI (Siebel et

al.), 1713-1725 role of SR and U1 snRNPs (Tam and

Steitz), 2704-2717 pre-mRNA, identification of associated

proteins (MacMillan et al.), 3008-3020

Prespliceosome components, SAP 49 and SAP 145 {Champion-Amaud and Reed), 1974-1983

Primitive streak role of

FGFR-1 (Deng et al.), 3045-3057 fgfr-1 in development {Yamaguchi et

al.), 3032-3044 Prion protein (Prp) gene, sheep, and sus-

ceptibility to natural scrapie (Westaway et al.), 959-969

Processing of mRNA, regulation by RNase E and RNase P (Alifano et al.), 3021-3031

Programmed cell death apoptosis, myc and p53 (Wagner et al.),

2817-2830 mouse Nedd2 is important component

of (Kumar et al.), 1613-1626 Prokaryotic glutamine synthetase I, As-

pergillus fluG gene related to (Lee and Adams), 641-651

Promoters alternative promoters (P1 and P2) of

mdm2 (Barak et al.), 1739-1749 clearance, role of basal factor TFIIE

(Maxon et al.), 515-524 DNA, activation domain enhance-

ment (Lierberman and Berk), 995-1006

Drosophila, interaction with TFIID (Purnell et al.), (830-842)

elements, transcriptional regulation by CDF2 {Iratni et al.), 2928-2938

of E2F1 (Hsiao et al.), 1526-1537 recognition of Inr elements by TFIID

(Kaufmann and Smale), 821-829 Proneural

activators, Drosophila imaginal disc, direct downstream targets of (Singson et al.), 2058-2071

genes, achaete-scute homologs in Xe- nopus embryo (Turner and Weintraub), 1434-1447

Protein kinase A (PICA), required for RNA lo-

calization along anteroposterior axis of Drosophila (Lane and Kalderon), 2986-2995

kinases activity of SAD1 (Allen et al.), 2401-

2415 Drosophila, new family--LAMMER

(Yun et al.), 1160-1173 localization, S. cerevisiae (Burns et

al.), 1087-1105 multimers, role in transposition

(Baker et al.), 2416-2428 synthesis

E. co// translational elongation factor SELB and selenoprotein synthesis (Ringquist et al.), 376- 385

regulation by codon usage under different growth states (Chen and Inouye), 2641-2652

in S. cerevisiae pap1-1 mutants (Proweller and Butler), 2629- 2640

Protein-DNA complexes, role in transposition (Baker et al.), 2416- 2428

Protein-protein interactions disruption of (Whipple et al.), 1212-

1223

between H and RBP-JK/KBF2 (Brou et al.), 2491-2503

POZ domain (Bardwell and Treisman), 1664-1677

Rad51 and Rad52 (Donovan et al.), 2552-2562

between RAP1 and SIR3 (Moretti et al.), 2257-2269

SAP 49-145 prespliceosome component complex (Champion-Ar- naud and Reed), 1974-1983

and specificity of HOX protein function (Zappavigna et al.), 732- 744

between TFIIA and TBP proteins (Sun et al.), 2336-2348

between Tupl and a2 (Komachi et al.), 2857-2867

Protein-tyrosine kinase, Abl SH3-binding sites (Ren et al.), 783-795

Proto-oncogene bmi-1, targeted deletion in transgenic

mice (van der Lugt et al.), 757- 769

mdm2, regulation of expression by p53 (Barak et al.), 1739-1749

c-myb, role in T-cell development (Ba- diani et al.), 770-782

c-myc, FUSE-binding protein {FBP) stimulates expression (Duncan et al.), 465-480

PRP 11P, component of U2 snRNP, interaction with MUD2P yeast protein (Abovich et al.), 843-854

Pseudohyphal growth, requirement of MAP kinase pathway (Roberts and Fink), 2974-2985

PSI RNA-binding protein, alternative splicing factor required for P-element pre-mRNA splicing {Sic- bel et al.), 1713-1725

PTHrP gene. See Parathyroid hormone- related peptide gene. See also Parathyroid hormone-related peptide

pyrB1 operon, regulation of expression by UTP-sensitive reiterative RNA synthesis (Liu et al.), 2904-2912

Pyrimidine gene expression, UTP-sensitive reiterative RNA synthesis {Liu et al.), 2904-2912

Pyrimidine-rich sequences, Trypano- soma brucei, relationship between trans-splicing and polyadenylation (Matthews et al.), 491-501

Quarternary complex, cyclin, CDK, PCNA, and p21 (Zhang et al.), 1750-1758

Quenching, Drosophila sna activity (Gray et al.), 1829-1838


RAD2, S. cerevisiae structure-specific endonuclease (Harrington and Lieber), 1344-1355

RAD6 and RAD18 proteins, S. cerevisiae, postreplication DNA repair (Bailly et al.), 811-820

RAD7 DNA repair gene, interaction with SIR3 gene {Paetkau et al.), 2035-2045

Rad51, interaction with Rad52, role in DNA repair (Donovan et al.), 2552-2562

Rad52, interaction with Rad51 in S. cerevisiae (Donovan et al.), 2552- 2562

RAD53, allelism to SAD1 (Allen et al.), 2401-2415

Raf serine/threonine kinase, specifies dorsoventral polarity in Droso- phila (Brand and Perrimon), 629-639

Raf, role of MEK in Drosophila (Hsu and Perrimon), 2176-2187

RAG gene expression, B-cell differentiation,~ role of v-abl in regulation of {Chen et al.), 688-697

Rag-l, role in V(D)J recombination process {Spanopoulou et al.), 1030- 1042

RAG-2-deficient mice, introduction of immunoglobulin HC and LC transgenes into (Young et al.), 1043-1057

RAP1, interaction with SIR proteins (Moretti et al.), 2257-2269

RAR-specific agonists, role in transcriptional activation (Valc~rcel et al.), 3068-3079

r a s

genes, C. elegans let-60 ras gene and vulval differentiation (Wu and Hart), 147-159

-mediated cell signaling, C. elegans vulval induction (Lackner et al.), 160-173

role of MEK in Drosophila (Hsu and Perrimon), 2176-2187

signal transduction, N-ras oncogene modulates transcription factor AP-2 (Kannan et al.), 1258-1269

signal transduction pathway, role of ets family members in (Giovane et al.), 1502-1513

signaling and ternary complex factors (Hipskind et al.), 1803-1816

and TGF-~I in squamous cell carcinoma (Glick et al.), 2429-2440

Rb growth suppressor protein, complexes

with E2F and inhibits transcription (Johnson et al.), 1514-1525

oncoprotein expression, role in mouse lens development {Pan and Griep), 1285-1299

RBP-JK, interaction with Drosophila hairless (Brou et al.), 2491-2503

rDNA minichromosome

excision and amplification in Tet- rahymena (Kapler and Black- bum), 84-95

Tetrahymena, excision and amplification of (Kapler and Black- bum), 84-95

transcription, role of S. cerevisiae RRN6 and RRN7 genes (Keys et al.), 2349-2362

transcriptional repression by CDF2 (Iratni et al.), 2928-2938

rec mutants, S. pombe (De Veaux and Smith), 203-210

RecA protein, E. coli single-strand transfer reaction, as compared to S. cerevisiae Sepl protein (Chen et al.), 1356--1365

Receptor tyrosine kinase (RTKs). See also RTK signaling pathways

Drosophila, signaling pathways (Reich- man-Fried et al.), 428-439

Drosophila Torso (Hsu and Perrimon), 2176-2187

role of Tek in mouse vasculogenesis (Dumont et al.), 1897-1909

Recombinase, site-specific developmen- tally regulated, encoded by An- abaena xisF gene (Carrasco et al.), 74-83

Recombination hot spots, correlation of heteromeric

protein binding and hot spot activity (Wahls and Smith), 1693- 1702

regulation of in S. pombe (De Veaux and Smith), 203-210

role in Mu transposase function (Baker et al.), 2416-2428

Reiterative transcription, role of pyrB1 operon (Liu et al.), 2904-2912

REMI (restriction enzyme-mediated integration) mutations, in Dicty- ostelium lagC (Dynes et al.), 948-958

Replication origin, activation of near a double-stranded DNA break (Raghuraman et al.), 554-562

Repression of class II promoters by Dr t (Yeung et

al.), 2097-2109 direct repression by E1B 55K (Yew et

al.), 190-202 Drosophila embryos, short-range tran-

scriptionaI repression involves quenching {Gray et al.), 1829- 1838

pole-specific repressor in Caulobacter (Wingrove and Gober), 1839- 1852

of rDNA transcription by CDF2 (Iratni et al.), 2928-2938

Repressor, global repressor Motl inhibits

TBP binding (Auble et al.), 1920-1934

Reproduction, regulation by SF-1 (Ingra- ham et al.), 2302-2312

Retinoblastoma, mice, role of p53 (Howes et al.), 1300-1310

Retinoblastoma protein (pRb) dual roles of during development {Lee

et a1.), 2008-2021 functional inactivation by collabora-

tion of GI cyclins (Hatakeyama et al.), 1758-1771

and growth inhibition, reversed by Id-2 binding to unphosphorylated pRb (Iavarone et al.), 1270-1284

Retinoic acid receptors

role in erythroid development (Tsai et al.), 2831-2841

RORa nuclear receptors related to {Gigudre et al.), 538-553

RXRa mutant mice, cardiac defects in {Sucov et al.), 1007-1018

Retinoid X receptor (RXR) (Tontonoz et al.), 1224-1234

a, component of vitamin A signaling pathway in mice cardiac morphogenesis (Sucov et al.), 1007- 1018

/RAR heterodimer, regulation of retinoid-dependent transcription (Valc~/rcel et al.), 3068-3079

Retinoids, transcriptional activation mediated by RXR/RAR heterodi- met (Valc~ircel et al.), 3068- 3079

Retrovirus E26, Myb-Ets fusion protein of (Kraut

et al.), 33-44 integration, distribution of targets

(Withers-Ward et al.), 1473- 1487

transduction of the C/EBP~ gene (Freytag et al.), 1654--1663

Rev trans-activator of HIV-1, nuclear export of (Meyer and Malim), 1538-1547

Reverse mutations, in mouse agouti locus (a to a t and A w) (Bultman et al.), 481-490

Ribonucleoproteins conservation of RNA moiety of telom-

erase RNA (Lingner et al.), 1984-1998

RNase MRP and RNase P (Lygerou et al.), 1423-1433

Tetrahymena telomerase (Autexier and Greider), 563-575

Ribosomes biogenesis, in Xenopus oocytes (Pecu-

lis and Steitz), 2241-2255 E. coli selenoprotein synthesis (Ring-

quist et al.), 376--385 proteins, and bacteriophage T4 group I

splicing (Coetzee et al.I, 1575- 1588


protein transcript RPL32, regulation of splicing by L32 protein (Vi- lardell and Warner), 211-220

RNA1 yeast gene, murine homolog of (fugl) (DeGregori et al.), 265- 276

RNA association between imprinted RNAs

and X chromosome inactivation (Pfeifer and Tilghman), 1867- 1874 Commentary

binding Drosophila, Sex-lethal amino- terminus mediates protein-protein interactions (Wang and Bell), 2072-2085

chaperones, E. coli proteins that stimulate group I splicing (Coetzee et al.), 1575-1588

editing, of rat and human WT1 (Wilms' tumor susceptibility gene) transcripts (Sharma et al.), 720-731

localization along anteroposterior axis of Droso-

phila requires PKA-mediated signals (Lane and Kalderon), 2986-2995

Drosophila oogenesis, distribution of Orb protein (Lantz et al.), 598-613

polymerase identification of regions involved in

RNA chain elongation (Weil- baecher et al.), 2913-2927

structure and function (Tang et al.), 3058-3067

stuttering, role of UTP-sensitive RNA synthesis (Liu et al.), 2904-2912

polymerase I, requirement of S. cerevisiae RRN6 and RRN7 (Keys et al.), 2349-2362

polymerase II cloning of yeast homolog of TFIIF

(Henry et al.), 2868-2878 cloning of yeast homologs (Khoo et

al.), 2879-2890 core promoters of, TFIID interacts

with TATA boxes and Inr elements (Kaufmann and Smale), 821-829

inhibition of transcription machinery by yeast NOT proteins (Col- lart and Struhl), 525-537

interaction with TBP (Tansey et al.), 2756-2769

TFIIE binds selectively to unphosphorylated form (RNA Pol IIa) (Maxon et al.), 515-524

transcription inhibited by Mot1 global repressor (Auble et al.), 1920-1934

processing coupling of

trans-splicing and polyadenylation (Matthews et al.), 491-501

intron removal and 3'-end formation (Nesic and Maquat), 363- 375

maize, role of AU-rich motifs (Lue- hrsen and Walbot), 1117-1130

role of RNase MRP and SNM1 (Schmitt and Clayton), 2617- 2628

yeast, POP1 gene (Lygerou et al.), 1423-1433

recognition motifs (RRMs), of U1 snRNP-A protein (Lutz and A1- wine), 576-586

replication, coupled to translation in poliovirus RNA genomes (No- yak and Kirkegaard), 1726-1737

secondary structure of telomerase (Lingner et al.), 1984-1998

splicing accuracy of Tetrahymena group I in-

tron reactions {Downs and Gech), 1198-1211

role of associated proteins {Mac- Millan et al.), 3008-3020

stability, in Xenopus oocytes (Peculis and Steitz), 2241-2255

synthesis, 3' end formation (Manley and Proudfoot), 259-264 Meet- ing Review

tertiary structure, Tetrahymena 5' splice set selection (Downs and Cech), 1198-1211

3' ends, formation and function (Man- ley and Proudfoot), 259-264 Meeting Review

virus, poliovirus, genome replication coupled to translation (Novak and Kirkegaard), 1726--1737

RNA-RNA interactions, tertiary interaction in the spliceosome (Mad- hani and Guthrie), 1071-1086

RNA-binding proteins Orb (Lantz et al.), 598-613, (Christer-

son and McKearin), 614-628 proteins, PSI is an alternative splicing

factor (Siebel et al.), 1713-1725 ternary complex formation with TLS

and EWS (Zinszner et al.), 2513- 2526

RNase E, role in processing of polycis- tronic mRNA (Alifano et al.), 3021-3031

RNase MRP characterization of a component

{Schmitt and Clayton), 2617- 2628

ribonucleoprotein, protein component in common with RNase P (Lygerou et al.), 1423-1433

RNase P involvement in segmental stabiliza-

tion of mRNA (Alifano et al.)i 3021-3031

ribonucleoproteiI1, protein component in common with RNase MRP (Lygerou et al.), 1423-1433

RNase MRP components (Schmitt and Clayton), 2617-2628

Ro, autoantigen, binding to mutant 5S rRNA (O'Brien and Wolin), 2891-2903

RORa, novel family of orphan hormone nuclear receptors, DNA-binding activities of isoforms (Gigu6re et al.), 538-553

rpoC, f~' subunit of RNA polymerase (Weilbaecher et al.), 2913-2927

rpoS/& expression, transcriptional and post-transcriptional signals that regulate expression in E. coli (Lange and Hengge-Aronis), 1600-1612

RRN6, role in initiation of rDNA transcription (Keys et al.), 2349- 2362

RRN7, role in initiation of rDNA transcription (Keys et al.), 2349- 2362

rRNA processing, in Xenopus oocytes (Peculis and Steitz), 2241-2255

RSRF (or MEF2) proteins, SL1 regulates cardiac muscle-specific transcription in Xenopus (Chambers et al.), 1324-1334

RTK signaling pathways, gene expression control by antirepression (Rusch and Levine}, 1247-1257

RTKs. See also Receptor tyrosine kinases

S

Saccharomyces cerevisiae. See also Yeast

activation of replication origin near a double-stranded DNA break (Raghuraman et al.), 554--562

Cl_3A-based silencing (Stavenhagen and Zakian), 1411-1422

conformational switch in U6 RNA (Fortner et al.), 221-233

DNA repair and chromatin structure {Paetkau et

al.), 2035-2045 complex of RAD6 and RAD18 pro-

teins (Bailly et al.), 811-820 G 1 cyclins CLN1 and CLN2 repress

mating factor response pathway {Oehlen and and Cross), 1058- 1070

large-scale screen for gene identification {Burns et al.), 1087-1105

M/G 1 transition, role of P40 sDBa5 (Donovan et al.), 1640-1653

MAP kinase Fus3 association with signaling component Ste5 (Kranz et al.), 313-327

mating type identity in et cells, role of SSN6 and TUP1 (Cooper et al.), 1400-1410

mimics cell cycle-dependent phospho-


rylation of mammalian pRB (Hatakeyama et al.), 1758-1771

mitotic checkpoint genes (Weinert et al.), 652-665

MOT1 gene encodes ADI (Auble et al.), 1920-1934

NOT-mediated repression of transcription machinery (Collart and Struhl), 525-537

Rad51 and Rad52 proteins (Donovan et al.), 2552-2562

requirement of MAP kinase pathway in pseudohyphal growth (Rob- erts and Fink), 2974-2985

ribosomal protein L32 regulates splicing of RPL32 gene transcript (Vilardell and Warner), 211-220

RNA processing and RNase MRP (Schmitt and Clayton), 2617-2628

RNase MRP and RNase P ribonucleoproteins have common protein component (Lygerou et al.), 1423-1433

role of SPS1 in spore formation (Frie- sen et al.), 2162-2175

role of RAP1 in transcriptional silencing (Moretti et al.), 2257-2269

Sepl strand exchange protein promotes a paranemic joint (Chen et al.), 1356-1365

SMK1 a MAP kinase homolog (Krisak et al.), 2151-2161

spliceosome assembly, MUD2 protein contacts PRPII during U2 snRNP recruitment (Abovich et al.), 843-854

tertiary interaction in the spliceosome (Madhani and Guthrie), 1071- 1086

SAD1, control of multiple cell cycle checkpoints in yeast (Allen et al.), 2401-2415

SAP-l, activation by RAS/MAP kinase- independent pathways (Hip- skind et al.), 1803-1816

SAP1 ets factor, as compared to new ets member Net (Giovane et al.), 1502-1513

SAP 49-145 prespliceosome component complex, role in U2 snRNP binding (Champion-Amaud and Reed), 1974-1983

SAPKcdI,_ cloning of INK2 a human homolog (Kallunki et al.), 2996-3007

Schizosaccharomyces pombe mating pheromone P-factor (Imai and

Yamamoto), 328-338 meiotic recombination, region-spe-

cific activators of (De Veaux and Smith), 203-210

recombination hot spot (Wahls and Smith), 1693-1702

SDB25. See P40 sDB2s Secondary structure

of telomerase RNAs (Lingner et al.), 1984-1998

of yeast U6 RNA (Fortner et al.), 221- 233

Secreted protein precursor, sog in dorsal pattern formation in Drosophila embryo (Frangois et al.), 2602- 2616

Segment polarity genes Drosophila (Cadigan et al.), 899-913

dishevelled (dsh) gene, role in Wg signaling (Klingensmith et al.), 118-130

wingless (wg) and engrailed (en) (Benedyk et aL), 105-117

Segmentation control of pair-rule gene expression

by a tyrosine kinase (Binari and Perrimon), 300-312. See also Pair-rule gene s

Drosophila (Benedyk et al.), 105-117 SELB translational elongation factor, E.

coli, identification of binding sites and interaction with initiation complex (Ringquist et al.), 376-385

Selenoprotein synthesis, E. coli, recognition of mRNA selenocysteine insertion sequence by SELB (Ringquist et al.), 376-385

Self-association, of Rad51, double-strand break repair (Donovan et al.), 2552-2562

Sensory organ precursor (SOP) cells, Drosophila (Singson et al.), 2058-2071

Sepl, S. cerevisiae strand exchange protein, promotes a paranemic joint (Chen et al.), 1356-1365

serendipity, regulation of bicoid transcription (Payre et al.), 2718- 2728

Serine/threonine kinase, activity of C. elegans unc-51 (Ogura et al.), 2389-2400

Serum albumin promoter, activation of by c/EBP~ (Nerlov and Ziff), 350-362

Sex determination Drosophila (Palmer et al.), 698-706

Sex-lethal (Sxl) gene (Wang and Bell), 2072-2085

snf gene, regulates Sxl splicing and encodes a snRNP protein (Flick- inger and Salz), 914-925

Sex-lethal (Sxl) gene, Drosophila Sex determination

system, alternative splicing of (Flickinger and Salz), 914-925

protein, Drosophila, RNA binding and splicing (Wang and Bell), 2072- 2085

Sex-specific regulation, of Drosophila msl-1 dosage compensation gene (Palmer et al.), 698-706

SF-1, nuclear receptor, role in reproduction {Ingraham et al.), 2302- 2312

SH3 domains (Ren et al.), 783-795 Sheep, Prp codon 171 and natural scrapie

(Westaway et al.), 959-969 short gastrulation (sog), pattern forma-

tion in Drosophila embryos (Frangois et al.), 2602-2616

0 "54 transcriptional activator, functions as pole-specific repressor in Caulobacter (Wingrove and Go ~ ber), 1839-1852

o's factor, regulation of expression in E. coli (Lange and Hengge-Aronis), 1600-1612

Signal transduction C-factor and cell movement in M. xan-

thus (Sager and Kaiser), 2793- 2804

in Dictyostelium, GBF transcription factor activation (Schnitzler et al.), 502-514

Drosophila oogenesis, novel role for Raf (Brand

and Perrimon), 629-639 role of dsh gene in Wg signaling

(Klingensmith et al.), 118-130 interaction between cAMP and cal-

cium (Sun et al.), 2527-2539 pathways

C. elegans vulval induction role of MAP kinase (Wu and Han),

147-159 role of mpk-1 (Lackner et al.),

160-173 c-Src tyrosine kinase (Guy et al.),

23-32 mice EGFR (Luetteke et al.), 399-

413 Ras (Giovane et al.), 1502-1513

role in transcriptional activation (Hip- skind et al.), 1803-1816

in S. cerevisiae (Friesen et al.), 2162- 2175

role in mating and invasive growth (Roberts and Fink), 2974-2985

MAP kinase Fus3 associates with signaling component Ste5 (Kranz et al.), 313-327

SMK1 and spore wall assembly (Krisak et al.), 2151-2161

U. maydis life cycle (Banuett and Her- skowitz), 1367-1378

Signaling molecules Dictyostelium LagC protein (Dynes et

al.), 948-958 Drosophila receptor tyrosine kinases

(RTKs) (Reichman-Fried et al.), 428--439

Tek RTK (Dumont et al.), 1897-1909 TGF-~ superfamily (Kingsley), 133-

146 Review Toll and tor (Rusch and Levine), 1247-

1257 vitamin A signaling in mice cardiac

morphogenesis (Sucov et al.), 1007-1018

Wnt family, Wnt-3a regulates gastru-


lation in mouse embryos (Ta- kada et al.), 174-189

Signaling protein, EGFR, mutations within have tissue specific con- sequences in mice (Luetteke et al.), 399-413

Signaling. See also cAMP signaling Silencers, CI__3A stretches of DNA in

yeast telomeres (Stavenhagen and Zakian), 1411-1422

Silencing. See also Transcriptional repression

SIR proteins, interaction with RAP1 proteins (Moretti et al.), 2257- 2269

SIR3 gene, S. cerevisiae silencing gene, interaction with RAD7 (Paet- kau et al.), 2035-2045

Site-specific recombinase. See also Re- combinase

Skeletal development, role of PTHrP (Karaplis et al.), 277-289

Skin disease, role of keratin 14 gene (Rugg et al.), 2563-2573, (Chan et al.), 2574-2587

SL1 protein, RSRF {or MEF2) family, regulates cardiac muscle-specific transcription in Xenopus (Chambers et al.), 1324-1334

sloppy paired (slp) locus, role in Droso- phila segmentation (Cadigan et al.), 899-913

snail (sna) zinc finger repressor, short- range repression in Drosophila (Gray et al.), 1829-1838

snf gene, Drosophila sex determination gene (Flickinger and Salz), 914- 925

SNM1, a component of yeast RNase MRP (Schmitt and Clayton), 2617-2628

snRNAs, U2 and U6, tertiary interactions (Madhani and Guthrie), 1071-1086

snRNPs association with branch sites of pre-

mRNA (MacMillan et al.), 3008-3020

protein, encoded by Drosophila snf sex determination gene (Flickinger and Salz), 914-925

spliceosome assembly {Abovich et al.), 843-854

U2/U4/U5/U6 (Konforti and Konar- ska), 1962-1973

Somite formation, mouse embryo, regulation by Wnt-3a (Takada et al.), 174-189

SP1 sites, role in methylation of CpG islands (Macleod et al.), 2282- 2292

Splice site recognition, of Sxl, role of snf (Flick-

inger and Salz), 914-925 selection, regulation by SR proteins

(Tam and Steitz), 2704-2717

Spliceosome assembly

MUD2 protein contacts PRPII (Abo- vich et al.), 843-854

recognition of branch site (Mac- Millan et al.), 3008-3020

regulation of ribosomal protein L32 occurs at intermediate step of assembly (Vilardell and War- ner), 211-220

branch formation (Query et al.), 587-597 inhibition of pre-mRNA splicing (Lu

et al.), 1817-1828 stem/loop structure in U6 RNA de-

fines conformational switch (Fortner et al.), 221-233

tertiary interaction in (Madhani and Guthrie), 1071-1086

5'SS RNA-U4/U5/U6 snRNP complex (Konforti and Konarska), 1962-1973

involvement of SR proteins (Tarn and Steitz), 2704-2717

Splicing. See also Alternative splicing; specific splicing factors

coupling of intron removal and 3'-end formation (Nesic and Maquat), 363-375

enhancement, and E. coli proteins (Co- etzee et al.), 1575-1588

enhancer, dsx repeat element (dsxRE), constitutive and regulated activities of (Tian and Maniatis), 1703-1712

linked to polyadenylation process (Lutz and Alwine), 576-586

maize, intron creation and polyadenylation directed by AU-rich motifs (Luehrsen and Walbot), 1117-1130

regulation, Drosophila Sex-lethal amino terminus is essential for {Wang and Bell), 2072-2085

ribosomal protein L32 regulates splicing of its own transcript (Vilardell and Warner), 211- 220

tertiary interaction in the spliceosome (Madhani and Guthrie), 1071- 1086

yeast, conformational switch in U6 RNA (Fortner et al.), 221-233

SpoIIAA, phosphorylation by SpoIIAB regulates transcription (Dieder- ich et al.), 2653-2663

SpoIIAB, regulation of transcription, phosphorylation of SpoIIAA (Diederich et al.), 2653-2663

Sporulation Aspergillus, extracellular rescue of

sporulation mutant (Lee and Adams), 641-651

B. subtilis coat assembly (Driks et al.), 234-244

regulation of transcription in B. subtilis (Diederich et al.), 2653-2663

role of S. cerevisiae SMK1 (Krisak et al.), 2151-2161

S. cerevisiae SPS1 gene (Friesen et al.), 2162-2175

SPS1, S. cerevisiae, role in spore formation (Friesen et al.), 2162-2175

Squamous cell carcinoma, involvement of TGF-~I (Glick et al.), 2429- 2440

SR protein, compensation for loss of U1 snRNP function (Tam and Steitz), 2704-2717

Src family, tyrosine kinases (Stein et al.), 1999-2007

src gene family, genetic interaction between family members (hck and fgr in mice (Lowell et al.), 387- 398

SRD-1 cells, sterol-resistant cell line (Yang et al.), 1910--1919

SRE (serum response element) of fos, Net binding requires SRF {Giovane et al.), 1502-1513

SREBP-2 transcription factor, role in cholesterol homeostasis (Yang et al.), 1910--1919

SRF (serum response factor), interaction with Net ets transcription factor (Giovane et al.), 1502-1513

SSN6 global transcriptional regulator, role in establishment of repressive chromatin structure (Coo- per et al.), 1400-1410

Ssn6, transcriptional repression (Koma- chi et al.), 2857-2867

Starvation signal, involvement in complex regulation of E. coli rpoS/cr s expression (Lange and Hengge- Aronis), 1600--1612

Stationary phase-induced genes, Esche- richia coli, regulation by crs factor (Lange and Hengge-Aronis), 1600-1612

Ste5 signaling component, S. cerevisiae, association with MAP kinase Fus3 possibly promotes signal transduction (Kranz et al.), 313- 327

STE20, homolog, SPS1 role in spore formation (Friesen et al.), 2162- 2175

Sterility, caused by disruption of ink8 in mice (Baribault et al.), 2964- 2973

Steroid-hormone receptor superfamily, effect on gastrulation (Chen et al.), 2466-2477

Sterol-regulated gene transcription (Yang et al.), 1910-1919

Strand transfer, S. cerevisiae Sepl protein (Chen et al.), 1356-1365

Structure of activation target of lac promoter

(Tang et al.), 3058-3067 of PPR1-DNA complex (Marmorstein

and Harrison), 2504-2512

GENES & DEVELOPMENT ,~1 O~

Su(H), interaction with H (Brou et al.), 2491-2503

Subcellular localization, in B. subtilds coat assembly (Driks et al.), 234--244

Substrate specificity, of JNKs towards c-Jun (Kallunki et al.), 2996- 3007

sur-1 gene, C. elegans MAP kinase, role in vulval signaling pathway (Wu and Han), 147-159

SV40 interaction of E1A-repressed enhanc-

ers and p300 (Eckner et al.), 869-884

upstream efficiency element (USE) of late polyadenylation signal (Lutz and Alwine), 576-586

T cells, development, role of transcription activator c-Myb (Badiani et al.), 770-782

T, in hindgut specification (Kispert et al.), 2137-2150

TAF30, indentity with TFG3 and mammalian ANC1 (Henry et al.), 2868-2878

TAFs activity of Drosophila TFIIA (Yoko-

mori et al.), 2313-2323 identification of yeast components

(Henry et al.), 2868-2878 participation in transcriptional activa-

tion (Lieberman and Berk), 995- 1006

TBP-associated factors, and species specificity of TBP (Cormack et al.), 1335-1343

Tailbud formation, mouse embryo, regulation by Wnt-3a (Takada et al.), 174--189

Targeted deletion, of TGF-[~I gene in mice (Glick et al.), 2429-2440

Targeted mutagenesis, and hematopoiesis (Weiss et al.), 1184-1197

TATA -binding

of Drosophila TFIIA (Yokomori et al.), 2313-2323

protein (TBP), yeast and human, conserved and nonconserved functions of (Cormack et al.), 1335-1343

box, recognition by TFIID (Kaufmann and Smale), 821-829

element, Drosophila (Purnell et al.), 830-842

utilization, and yeast NOT proteins (Collart and Struhl), 525-537

TBP. See also TATA-binding proteins binding to BRF (Khoo et al.), 2879-

2890 binding, inhibited by global repressor

Motl (Auble et al.), 1920-1934

interaction with Dr 1 mediates transcriptional repression (Yeung et al.), 2097-2109

role in transcriptional activation (Tan- sey et al.}, 2756--2769

TEF-1, role in cardiogenesis (Chen et al.), 2293-2301

Tek receptor tyrosine kinase, role in mouse vasculogenesis (Dumont et al.), 1897-1909

Telomerase common secondary structure and per-

muted template {Lingner et al.), 1984-1998

ribonucleoprotein, reconstitution of wild-type and mutant (Autexier and Greider), 563-575

Telomeres conservation of telomerase RNA sec-

ondary structure (Lingner et al.), 1984-1998

elongation, reconstitution of Tetrahy- mena telomerase (Autexier and Greider), 563-575

transcriptional silencing induced by RAP1 and SIR proteins (Moretti et al.), 2257-2269

yeast (Stavenhagen and Zakian), 1411-1422

position-effect at (Aparicio and Gottschling), 1133-1146

replication (Raghuraman et al.), 554-562

Telomeric position effect (TPE), transcriptional repression in yeast (Stavenhagen and Zakian), 1411-1422

Termination. See also Transcriptional termination

Ternary complex factors, role in RAS/ MAP kinase-dependent and -independent signaling pathways (Hipskind et al.), 1803-1816

Tetrahymena thermophila accuracy of group I intron reactions

(Downs and Cech), 1198-1211 rDNA excision and amplification (Ka-

pier and Blackburn), 84-95 rDNA minichromosome, germ-line

mutation prevents amplification (Kapler and Blackburn), 84-95

telomerase enzyme mechanism (Au- texier and Greider), 563-575

TFIIA human, role

in transcriptional activation (Ozer et al.), 2324-2335, (Sun et al.), 2336-2348

and regulation of Xenopus chromosomal 5S rRNA genes (Bouvet et al.), 1147-1159

transcriptional activation in Droso- phila (Yokomori et al.), 2313- 2323

TFIIB, role of BRF in transcription (Khoo et al.), 2879-2890

TFIID, binding to TBP (Tansey et al.), 2756-2769

TFIIF, cloning of yeast homolog (Henry et al.), 2868-2878

TFG1, subunit of yeast TFIIF (Henry et al.), 2868-2878



TFIID binding, Drosophila, downstream con-

tacts (Purnell et al.), 830-842 complex, recognizes promoter Inr ele-

ments and TATA boxes (Kauf- mann and Smale), 821-829

TFIID-TFIIA-promoter binding, activation of (Lieberman and Berk), 995-1006

TFIIH basal factor, recruited by basal factor TFIIE (Maxon et al.), 515- 524

TGF-~ superfamily (Kingsley), 133-146 Review

pattern formation in Drosophila embryos (Frangois et al.), 2602- 2616

TGF-~I, in squamous cell carcinoma (Glick et at.), 2429-2440

3'-Untranslated regions (3' UTRs), of c-mos and cyclin mRNAs, role in translational control (Sheets et al.), 926-938

Thrombocytopenia, in PDGF B-deficient mice (Levhen et al.), 1875-1887

Tissue culture, bHLH factors in myogenesis (Olson and Klein), 1-8 Re- view

Tissue-specific gene expression, myogenesis, bHLH regulatory factors (Olson and Klein), 1-8 Re- view

TLS, binding to CHOP (Zinszner et al.), 2513-2526

TLS-CHOP, oncogenic variant of CHOP, blocks induction of G1/S arrest in adipose tissue (Barone et al.), 453-464

TOA2, identification of human homolog, TFIIA-~/ (Ozer et al.), 2324--2335

Toeprint experiments, SELB binding to mRNA in E. coli (Ringquist et al.), 376-385

Toll signaling pathway, regulation of dorsal morphogen (Rusch and Levine), 1247-1257

Tor signaling pathway, regulation of dorsal morphogen (Rusch and Levine), 1247-1257

Torsional tension, not required for replication origin activation (Ra- ghuraman et al.), 554-562

Torso, role of MEK in Drosophila (Hsu and Perrimon), 2176-2187

TPI gene, interactions of polyadenyla-


tion and splicing (Nesic and Ma- quat), 363-375

Tracheal development, Drosophila, role of breathless (Reichman-Fried et al.), 428--439

Trans-activation domain, of C/EBP~ (Nerlov and Ziff),

350-362 of E-box element of c-myc (Hann et

al.), 2441-2452 hydrophobic amino acids in p53

amino-terminal domain (Lin et al.), 1235-1246

of RAR promoter by RXR (Valc~ircel et al.), 3068-3079

Trans-activators yeast PPR1 overcomes telomeric si-

lencing in cell-cycle-dependent way (Aparicio and Gottschling), 1133-1146

Trans-active mutant, of Tn5 (Weinreich et al.), 2363-2374

Trans-splicing, as related to polyadenylation {Matthews et al.), 491-501

Transcription activation

DNA-binding domain of rat glucocorticoid receptor (Lefstin et al.), 2842-2856

of genes at late G 1 (Zhu et al.), 885- 898

induced by human TFIIA (Ozer et al.), 2324-

2335, (Sun et al.), 2336-2348 RXR/RAR heterodimers (Valc~r-

cel et al.), 3068-3079 TFIIA in Drosophila (Yokomori et

al.), 2313-2323 of the lac promoter (Tang et al.),

3058-3067 by mi (Hemesath et al.), 2770-2780 mechanism for TAFs (Lieberman

and Berk), 995-1006 RAS/MAP kinase-dependent and

-independent signaling pathways (Hipskind et al.), 1803- 1816

role of TBP (Tansey et al.), 2756- 2769

cr s4 functions as pole-specific repressor in Caulobacter (Wingrove and Gober), 1839-1852

activator DNA-binding factor c-Myb, role in

T-cell development (Badiani et al.), 770-782

HAP1, asymmetric (Zhang and Guarente), 2110-2119

adaptor protein, adenovirus E1A-associated 300-kD protein (p300) (Eckner et al.), 869-884

[~-globin (Barton and Emerson), 2453- 2465

cardiac muscle-specific in Xenopus embryos (Chambers et al.), 1324-1334

cloning of yeast TFIIF (Henry et al.), 2868-2878

complexes GABP (de la Brousse et al.), 1853-

1865 Zta-TFIID-TFIIA-promoter com-

plex (Lieberman and Berk), 995- 1006

DNA-damage induced in yeast (Allen et al.), 2401-2415

of Drosophila achaete regulated by hairy (Van

Doren et al.), 2729-2742 male X chromosome genes (Bone et

al.), 96-104, 277-289 factors,

AP-2, transformation by N-ras oncogene (Kannan et al.), 1258-1269

bicoid controlled by serendipity (Payre et al.), 2718-2728

CCAAT/enhancer binding protein-c~ (C/EBP~, activation of serum albumin promoter (Nerlov and Ziff), 350-362

CHOP, interaction with TLS (Zin- szner et al.), 2513-2526

cloning of BRF homologs from K. lactis and C. albicans (Khoo et al.), 2879-2890

crystal structure of E47 (Ellenberger et al.), 970-980

Drosophila \ development (Fuse et al.), 2270-

2281 homeo domain proteins eve and

ftz, DNA targets of (Walter et al.), 1678-1692

TFIID (Purnell et al.), 830-842 E2F, regulation of linked to cell cy-

cle-dependent activation of kinases (Dynlacht et al.), 1772--1786

E2F-4 and transformation (Ginsberg et al.), 2665-2679, (Beijersber- gen et al.), 2680-2690

G-box binding factor, Dictyostelium development (Schnitzler et al.), 502-514

GATA-1 loss in mouse ES cells (Weiss et al.), 1184-1197

HNF-4, role in mouse development (Chen et al.), 2466-2477

IIE (TFIIE), interaction with other basal factors and RNA Pol II (Maxon et al.), 515-524

murine PPAR (mPPAR~/2), adipocyte-specific (Tontonoz et al.), 1224-1234

Net (new ets member) activation by Ras (Giovane et al.), 1502-1513

NF-M regulation by phosphorylation (Kowenz-Leutz et al.), 2781-2791

Pax (paired box) family (Epstein et al.), 2122-2134

PPR1, crystal structure (Marmor- stein and Harrison), 2504-2512

TEF-1 in mice (Chen et al.), 2293- 2301

TFIIE recruits TFIIH (Maxon et al.), 515-524

yeast RRN6 and RRN7 genes (Keys et al.), 2349-2362

human, TFIIA-dependent (Sun et al.), 2336-2348

inhibition Rb/E2F complex (Johnson et al.),

1514-1525 by yeast NOT complex (Collart and

Struhl), 525-537 initiation

recognition of core promotor elements (Kaufmann and Smale), 821-829

regulation by pyrB1 operon (Liu et al.), 2904-2912

interaction, by Drosophila H and Su(H) (Brou et al.), 2491-2503

of K gene in pre-B lymphocytes (Klug et al.), 678-687

regulation by cAMP and calcium (Sun et al.),

2527-2539 growth regulation of E2F1 promoter

(Hsiao et al.), 1526-1537 HOX protein interactions and HOX

gene promoters (Zappavigna et al.), 732-744

UME6, nitrogen repression and meiotic development (Strich et al.), 796-810

by interactions between SpoIIAA and SpoIIAB in B. subtilis (Died- erich et al.I, 2653-2663

repression direct repression by E1B 55K of

p53 activity (Yew et al.), 190- 202

induced by Tupl and Ssn6 (Komachi et al.), 2857-2867

of rDNA by CDF2 (Iratni et al.), 2928-2938

selectively masked by a receptor tyrosine kinase (Rusch and Levine), 1247-1257

telomeric position effect (TPE) in yeast (Stavenhagen and Zakian), 1411-1422

yeast, repression of a cell-specific expression in c, cells (Cooper et al.), 1400-1410

repression of class II genes by Dr 1 (Yeung et al.),

2097-2109 Drosophila achaete by hairy

(Ohsako et al.}, 2743-2755 MyoD by IgH enhancer (Weintraub

et al.), 2203-2211 repressors. See also Repression self-interference, resulting from high-

level expression of transcription factor AP-2 (Kannan et al.), 1258-1269


silencing. See also Transcriptional repression

induced by RAP1 mutants (Moretti et al.), 2257-2269

yeast SIR3 gene (Paetkau et al.), 2035-2045

termination as related to initiation, elongation

and polyadenylation (Manley and Proudfoot), 259-264 Meet- ing Review

role of RNA polymerase (Weft- baecher et al.}, 2913-2927

RNA polymerase II, Motl global repressor of (Auble et al.), 1920- 1934

Xenopus chromosomal 5S rRNA, in vivo regulation by histone H1 (Bouvet et al.), 1147-1159

yeast and human TATA-binding proteins (Cormack et al.), 1335- 1343

Transesterification reactions, splicing (Query et al.), 587-597

Transformation induced by E2F-4 (Beijersbergen et al.),

2680-2690, (Ginsberg et al.), 2665-2679

N-ras induced, role of transcription factor AP-2 (Kannan et al.), 1258-1269

Transformer (Tra) and Transformer2 (Tra2) proteins, Drosophila, and dsxRE activity (Tian and Maniatis), 1703-1712

Transforming growth factor-f~. See also TGF-~

and cell cycle arrest (Polyak et al.), 9- 22

superfamily, activins and inhibins (Vassalli et al.), 414-427

Transgenic mice apoptosis or retinoblastoma (Howes et

al.), 1300-1310 c-Src required for induction of mam-

mary turmorigenesis (Guy et al.), 23-32

HPV-16 E6 or E7 (Pan and Griep), 1285-1299

Translation codon usage, regulation during differ-

ent growth stages (Chen and In- ouye), 2641-2652

coupled to RNA replication in poliovirus (Novak and Kirkegaard), 1726-1737

effect on initiation in S. cerevisiae papl-1 mutants (Proweller and Butler), 2629-2640

elongation factor SELB, identification of binding sites and interaction with initiation complex in E. coli (Ringquist et al.), 376-385

and polyadenylation (Manley and Proudfoot), 259-264 Meeting Review

role of RNase E and RNase P (Alifano et al.), 3021-3031

Translational control alternative mdm2 promoters produce

transcripts with different translation potentials (Barak et al.), 1739-1749

poly(A) addition to mRNAs during early development (Bilger et al.), 1106-1116

via 3' UTR regulation of cytoplasmic polyadenylation (Sheets et al.), 926-938

Transposable element, Drosophila gypsy element-retrotransposon or retrovirus (Song et al.), 2046-2057

Transposase, activity of bacterial Trip (Weinreich et al.), 2363-2374

Transposition, promotion by tetramer of Mu (Baker et al.), 2416-2428

Transposon Tel, tagging to C. elegans unc-51

(Ogura et al.), 2389-2400 Tn5, nonproductive multimerization

(Weinreich et al.), 2363-2374 Trg, in hindgut specification (Kispert et

al.), 2137-2150 Tribolium (Kispert et al.), 2137-2150 Trichome development, Arabidopsis,

role of GL2 homeo box gene (Rerie et al.), 1388-1399

trithorax, regulation of expression in Drosophila (Kuzin et al.), 2478- 2490

tRNA, least abundant form regulates expression (Chen and Inouye), 2641-2652

Trypanosoma brucei, coupling of trans- splicing and polyadenylation requires pyrimidine-rich motif (Matthews et al.), 491-501

Tumor cell, proliferation, role of TGF-~I

(Glick et al.), 2429-2440 suppressor, p53, role in Myc-mediated

apoptosis (Wagner et al.), 2817- 2830

suppressor gene human DCC (Hedrick et al.), 1174--

1183 Nfl (Brannan et al.), 1019-1029 p53, regulation of mdm2 expression

(Barak et al.), 1739-1749 products p53 and Rb, role in routine

lens morphogenesis (Pan and Griep), 1285-1299

RB (Howes et al.), 1300-1310 Tumorigenesis. See also Colorectal tum-

origenesis TUP1 global transcriptional regulator,

role in establishment of repressive chromatin structure (Coo- per et al.), 1400-1410

Tup 1, interaction with homeo domain of c~2 (Komachi et al.), 2857-2867

Twisted gastrulation gene, Drosophila,

encodes protein related to human connective tissue growth factor (Mason et al.), 1489-1501

Two-hybrid interaction between Rad51 and Rad52

(Donovan et al.), 2552-2562 screen for

CDK6-interacting proteins (Guan et al.), 2939-2952

RAPl-interacting factors (Moretti et al.), 2257-2269

system S. cerevisiae, interaction of RAD7

and SIR3 gene products (Paet- kau et al.), 2035-2045

yeast, Drl-TBP interaction (Yeung et al.), 2097-2109

Tyrosine kinase receptor, epidermal growth factor receptor (EGFR) (Luetteke et al.), 399-413

Tyrosine kinases. See also c-Src combined deficiencies of Src, Fyn, and

Yes in mutant mice (Stein et al.), 1999-2007

encoded by Drosophila hop gene, stripe-specific regulation of pair-rule genes (Binari and Per- rimon), 300-312

v-abl negatively regulates NF-KB/Rel

function (Klug et al.), 678-687 suppresses light-chain rearrange-

ment (Chen et al.), 688-697

U

U1 snRNP-A protein, direct interaction with USE of SV40 (Lutz and A1- wine), 576-586

U1 snRNPs, functional replacement by SR proteins (Tam and Steitz), 2704--2717

U2 snRNP binding, SAP 49-145 complex implicated in (Champion- Arnaud and Reed), 1974--1983

U4/U5/U6 snRNP, recognition of 5' splice site (Konforti and Konar- ska), 1962-1973

U6 RNA, S. cerevisiae, stem/loop structure defines conformational switch required for pre-mRNA splicing (Fortner et al.), 221-233

U6 snRNA, association of pre-mRNA splicing {Lu et al.), 1817-1828

uacl, induction of filamentous growth in U. maydis (Gold et al.), 2805-2816

ubcl, regulation of morphogenesis in U. maydis (Gold et al.), 2805-2816

Ubiquitin-conjugating enzyme, S. cerevisiae postreplication DNA repair (Bailly et al.), 811-820

UME6 transcriptional regulator identical to CAR80/CARGRI (Strich

et al.), 796-810


of nitrogen repression and meiotic development (Strich et al.), 796- 810

unc-51, C. elegans, role in axonal elongation (Ogura et al.), 2389-2400

Upstream efficiency element (USE), of SV40 late polyadenylation signal, interaction with U1 snRNPA protein (Lutz and A1- wine), 576-586

Ustilago maydis Fuz7 identification, a MEK/MAPKK

homolog (Banuett and Her- skowitz), 1367-1378

role of cAMP in morphogenesis (Gold et al.), 2805-2816

UV cross-linking, SAP 49 to pre-mRNA in prespliceosome complex (Champion-Arnaud and Reed), 1974-1983

UV-damaged DNA, postreplication repair in S. cerevisiae (Bailly et al.), 811-820

V

V(D)J recombination B- and T-cell development (Young et

al.), 1043-1057 role of Rag-1 (Spanopoulou et al.),

1030-1042 v-abl

tyrosine kinase, block light-chain rearrangement (Chen et al.), 688- 697

viral transforming protein (tyrosine kinase), blocks K gene transcription in pre-B lymphocytes (Klug et al.), 678-687

Vacuole, delivery of proteins to (Bachha- wat et al.), 379-1387

Vision, Drosophila, role of repo gene (Xiong et al.), 981-994

Vitamin A, signaling pathway in mice cardiac morphogenesis (Sucov et al.), 1007-1018

VL30 insertion elements, in mouse agouti- locus (Bultman et al.), 481-490

Vulval development, C. elegans, role of MAP

kinase homolog mpk-1 (Lackner et al.), 160-173

differentiation, C. elegans, negative regulation of and unc-lO1 gene (Lee et al.), 60-73

W

wa-2 mouse defect, naturally occurring EGFR mutation (Luetteke et al.), 399--413

Wave propagation, C-factor, M. xanthus (Sager and Kaiser), 2793-2804

WD repeats, of Tupl interact with e~2 (Komachi et al.), 2857-2867

Wilms' tumor (WT) susceptibility gene

(WT1), RNA editing in (Sharma et al.), 720-731

wingless (wg) segment polarity gene, Drosophila (Benedyk et al.), 105- 117, (Cadigan et al.), 899-913

Wingless (Wg) signaling, Drosophila, and role of dsh (Klingensmith et al.), 118-130

Wnt signaling molecules, Wnt-3a regulates gastrulation in mouse embryos (Takada et al.), 174-189

WT1. See Wilms' tumor susceptibility gene.

X

X chromosome inactivation, association with imprinting (Pfeifer and Til- ghman), 1867-1874 Commen- tary

Xenopus laevis embryos, SL1 protein regulates cardiac

muscle-specific transcription (Chambers et al.), 1324-1334

5S rRNA processing (O'Brien and Wo- lin), 2891-2903

oocyte, 5S rRNA genes, histone HI- regulated transcription in vivo (Bouvet et al.), 1147-1159

polyadenylation and translation of maternal mRNAs (Sheets et al.), 926-938

proneural function of achaete-scute homologs ASH3a and ASH3b (Turner and Weintraub), 1434- 1447

snRNP function (Peculis and Steitz), 2241-2255

transcription of f~-globin (Barton and Emerson), 2453-2465

Xbra gene (homolog of mouse gene Brachyury), neuralizing activity of mutant (Rao), 939-947

XMyoD regulation (Rupp et al.), 1311- 1323

xisF gene, Anabaena, encodes develop- mentally regulated site-specific recombinase (Carrasco et al.), 74--83

Xist RNA, and X chromosome inactivation (Pfeifer and Tilghman), 1867-1874 Commentary

XKL51 O, S. cerevisiae structure-specific endonuclease (Harrington and Lieber), 1344-1355

Yeast. See also Saccharomyces cerevisiae; Schizosaccharomyces pombe

growth inhibition by mutant glucocorticoid receptors (Lefstin et al.), 2842-2856

homolog, of mouse H~58 gene (Bach- hawat et al.), 1379-1387

MAP kinase cascade (Krisak et al.), 2151-2161

position-effect at telomeres (Aparicio and Gottschling), 1133-1146

RNA1 gene fugl is murine homolog of (DeGre-

gori et al.), 265-276 routine homolog of (fugl) (DeGre-

gori et al.), 265-276 similarity between S. pombe P-factor

and S. cerevisiae e~-factor (Imai and Yamamoto), 328-338

TATA-binding protein {TBP) as compared to human TBP (Cormack et al.), 1335-1343

transcriptional activator HAP1, DNA- binding domain (Zhang end Guarente), 2110-2119

UME6 and CAR80/CARGRI are identical (Strich et al.), 796-810

Yes, tyrosine kinase Src family (Stein et al.), 1999-2007

Z

Zebra fish dominant-negative acivin variants in

(Michaud et al.), 1463-1472 embryo, POU domain gene pou2, al-

ternately spliced products of (Takada et al.), 45-59

ZID (zinc finger protein with interaction domain), contains POZ protein-protein interaction domain {Bardwell and Treisman), 1664--1677

Zinc cluster, S. cerevisiae SNM1 (Schmitt and Clayton), 2617-2628

Zinc finger protein

Drosophila, encoded by pair-rule gene odd-paired (opa) (Benedyk et al.), 105-117

serendipity and regulation of bicoid transcription (Payre et al.), 2718-2728

ZID (zinc finger protein with interaction domain) contains POZ domain (Bardwell and Treis- man), 1664--1677

repressor, Drosophila snail (sna} functions through short-range repression (Gray et al.), 1829-1838

role in DNA binding (Marmorstein and Harrison), 2504--2512

Zn2Cys6, binuclear cluster of PPR1 and GAL4, role in DNA recognition (Marmorstein and Harrison), 2504--2512

Zta activation domain, of Epstein-Barr vi o

rus, interaction with TFIID- TFIIA-promoter complex (Lie- berman and Berk), 995-1006

binding to TFIIA (Ozer et al.), 2324- 2335


INFORMATION FOR CONTRIBUTORS (1994)

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