Reviewers, Volume 6" (1992) The Editors would like to thank the Editorial Board and the following scientists who were kind enough to review papers and provide advice during 1992. Your help has been invaluable and is greatly appreciated.

* From November 18, 1991 to November 16, 1992

Aaronson, Stuart Adler, Paul Alt, Fred Altman, Sid Ammeter, Gustav Anderson, David Anderson, Kathryn Ares, Manuel Amdt, Kim Amold, Hans Artavanis-Tsakonas, Spyros Ausubel, Fred Baeuerle, Patrick Baker, Bruce Baldwin, Albert Baltimore, David Banerjee, Utpal Barbacid, Mariano Beach, David Beddington, Rosa Beemon, Karen Beene, Michael Belfort, Marlene Bentley, David Berk, Arnold Beme, Michael Betas, Anton Bemstein, Alan Bienz, Mariann Biggin, Mark Bingham, Paul Bird, Adrian Bishop, J. Michael Bissell, Mina Blackburn, Elizabeth Boeke, Jeff Botchan, Michael Bothwell, AI Bradley, Allan Breeden, Linda Brimacombe, Richard Broach, James Brockes, Jeremy Brown, Donald Bryant, Peter Buchman, Andrew Burr, Ben Calame, Kathryn Campbell, Judith Capecchi, Mario Carey, Michael Carlson, Mary Ann

Carroll, Sean Chaconas, George Chater, Keith Chesebro, Bruce Chory, Jo Anne Clayton, David Cleveland, Donald Cline, Thomas Coen, Enrico Cole, Michael Collins, Francis Corces, Victor Costantini, Frank Cox, Michael Crabtree, Gerald Craig, Elizabeth Craig, Nancy Cullen, Bryan Curran, Tom Darnell, James DePamphilis, Mel Desplan, Claude Devreotes, Peter DiMaio, Dan Doe, Chris Donahue, Tom Donovan, Peter Dunphy, William Driever, Wolfgang Dynan, Bill Efstratiadis, Argiris Ehrenfeld, Ellie Eichele, Gregor Eisenman, Bob Emerson, Charles Engel, Douglas Esposito, Rochelle Evans, Ronald Fangman, Walter Fanning, Ellen Fedoroff, Nina Felsenfeld, Gary Feramisco, Jim Fields, Stanley Fink, Gerald Firtel, Richard Foumier, Keith Freeling, Mike Friedman, David Fu, Xin-Yuan Fuchs, Elaine Futcher, Bruce Fyrberg, Eric Ganem, Don Gaynor, Richard Gehring, Walter Gelbart, William Gerandakis, Steve Gergen, Peter Gilman, Mike Glover, David Goodman, Corey Gralla, Jay Graves, Barbara

Green, Michael Greenberg, Michael Greenblatt, Jack Greene, Warner Greenleaf, Amo Greider, Carol Grosschedl, Rudolf Gruss, Peter Gurdon, John Hahn, Steve Hamlin, Joyce Hanahan, Doug Harland, Richard Harlow, Edward Harper, Jeff Harrison, Steven Hartenstein, Volker Hartley, David Hayday, Adrian Hearing, Patrick Helfman, David Hemandez, Nouria Herrlich, Peter Hershey, John Herskowitz, Ira Hieter, Phil Hill, Robert Hinnebusch, Alan Hirsch, Jay Hochstrasser, Mark Hopper, Anita Hopwood, David Hovanessian, Ara Howley, Peter Huberman, Joel Hudson, Andrew Hughes, Steven Hunter, Tony Hynes, Richard Inouye, Masayori Ish-Horowicz, David Jackson, Ian Jaeckle, Herbert Jaenisch, Rudi Jan, Yuh-Nung Jessell, Thomas Johnson, Peter Johnson, Alexander Jolicoeur, Paul Jones, Katherine Joyner, Alex Kadesch, Tom Kadonaga, James Kaiser, Dale Kaiser, Kim Karin, Michael Kessin, Richard Kingston, Robert Kintner, Chris Kleckner, Nancy Klessig, Daniel Knowles, Barbara Kolodner, Richard Konieczny, Stephen

2666 GENES & DEVELOPMENT

Komberg, Thomas Krainer, Adrian Kramer, Angela Krasnow, Mark Krisch, Henry Krug, Robert Krumlauff, Robb Kushner, Sydney Lamond, Angus Laskey, Ron Lassar, Andrew Leder, Philip Lehmann, Ruth Leptin, Maria Levine, Michael Levy, David Lichtenstein, Conrad Lis, John Liu, Leroy Livingston, David Lowy, Doug Lucas, William Maniatis, Tom Marlzuff, William Martienssen, Rob Mathews, Mike McClure, William McKay, Ron McKeown, Mike Melton, Doug Meyer, Barbara Meyerowitz, Elliott Mizuuchi, Kiyoshi Molloy, Peter Moran, Charles Moran, Elizabeth Morris, Ron Murray, Andrew Nabel, Gary Nadal-Ginard, Bemardo Nevins, Joseph Newman, Andrew Nomura, Masayasu Novick, Richard Nurse, Paul Nusse, Roel O'Farrell, Patrick 0liver, Donald Olson, Eric Oren, Moshe Orkin, Stuart Pabo, Carl Pace, Norman Parada, Luis Perlman, Phil Posakony, James Prescott, David Preston, Chris Prives, Carol Proudfoot, Nick Ptashne, Mark Quail, Peter Racaniello, Vincent Rao, N. Rechsteiner, Martin Reed, Robin

Reed, Steven Reeder, Ronald Reinberg, Daniel Renkawitz, R. Reznikoff, Bill Rheinwald, Jim Rigby, Peter Riggs, Arthur Rio, Donald Roberts, Jeff Roberts, Jim Roeder, Robert Rosbash, Michael Rose, Mark Rosen, Craig Rosenfeld, Geoff Ross, Jeff Rossant, Janet Rotter, Varda Russell, Paul Rutter, William Ruvkun, Gary Sakano, Hitoshi Sassone-Corsi, Paolo Schedl, Paul Scheres, Ben Scholer, Hans Schupbach, Trudi Segall, Jacqueline Sharp, Philip Sherr, Charles Shimkets, L. Shore, David Silhavy, Tom Silver, Lee Simon, Melvin Smale, Steven Smith, Gerald Smith, Issar Smith, Jim Sollner-Webb, Barbara Sonnenberg, Nahum Soriano, Philippe Spector, David Spiegelman, Bruce Spradling, Alan Sprague, George Stavnezer, Edward Stenlund, Ame Stemglanz, Roll Steward, Ruth Stillman, Bruce Storb, Urusla Stragier, Patrick Strickland, Sidney Struhl, Gary Struhl, Kevin Stunnenberg, H. Surani, Azim Susskind, Miriam Szostak, Jack Tatchell, Kelly Taylor, Michael Tegtmeyer, Peter Thomer, Jeremy Thummel, Carl

Timberlake, William Treisman, Richard Triezenberg, Steven Tye, Bik van der Vliet, Peter Van Dyke, Terry van Montagu, Mark Vassali, Jean-Dominique Vennstrom, Bjom Verma, Inder Voellmy, Richard Vogt, Peter Wahl, Geoff Walbot, Virginia Walsh, Frank Warner, Anne Wassarman, Paul Weinberg, Robert Weiner, Alan Weintraub, Harold Weissman, Charles Wessler, Sue Westphal, Henry White, Eileen Wickens, Marvin Wieschaus, Eric Wilkinson, David Willison, Keith Winston, Fred Wolffe, Alan Wolgemuth, Deborah Woolford, John Wormington, Michael Wright, Chris Wu, Carl Yamamoto, Keith Yaniv, Moshe Yanofsky, Carl Young, Michael Young, Richard Zakian, Virginia Ziff, Edward Zipursky, Larry Zucker, Charles

GENES & DEVELOPMENT 2667

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2668 GENES & DEVELOPMENT

Author Index, Volume 6 (1992) Abel, T., 466 Abravaya, K., 1153 Adams, B., 1589 Adzuma, K., 1679 Atfolter, M., 1082 Aguzzi, A., 1589 Aizawa, S., 1821 Akizawa, T., 2066 Alley, M.R.K., 825 Almir6n, M., 2646 Alonso-Caplen, F.V., 255 Alt, F.W., 61, 2248 Altman, E., 1165 Amberg, D.C., 1173 Ammerer, G., 1280 Anderson, C.W., 426 Androphy, E.J., 105 Ariel, M., 705 Amdt, K.M., 1319 Amdt, K.T., 2417 Arnold, H.H., 888 Auerbach, B.A., 691, 903 Awedimento, E.V., 1621 Baeuerle, P.A., 2352 Baichwal, V.R., 1493 Baker, B.S., 2569 Baker, T.A., 2221 Baldwin Jr., A.S., 1899 Baltimore, D., 775 Bang, A.G., 1752 Bannister, A.I., 1810 Bargonetti, J., 1143 Bargonetti, 1., 1886 Barker, D.D., 2312 Bartelmez, S., 2258 Barton, S.C., 1843 Baserga, S.I., 1120 Beckman, D.L., 268 Bedell, M.A., 1832 Beg, A.A., 1899 Behrendtsen, O., 939 Behrens, S.-E., 631 Belasco, J.G., 135 Belfort, M., 1269 Bell-Pedersen, D., 2382 Bellen, H.J., 2125 Benezra, R., 1466 Bennett, M., 1986 Bentley, D.L., 1562 Benusiglio, E., 1621 Benvenisty, N., 2513 Berberich, S.J., 166 Berk, A.J., 1964 Bemstein, P.L., 642 Bestor, T.H., 2536 Beug, H., 876 Bhatt, R., 466 Bier, E., 1503, 1728, 2137 Biere, A.L., 2409 Biggin, M.D., 1531 Bird, A., 876 Blackwood, E.M., 71 Blundell, P.A., 14 Bober, E., 888

Boehmelt, G., 876 Bolado, J., 578 Bonapace, I.M., 1621 Bonnez, W., 1131 Borgmeyer, U., 329, 578 Bossy-Wetzel, E., 2340 Bouly, I--P., 1019 Bouvet, P., 135 Boyer, T.G., 1964 Brandeis, M., 705 Brannan, C.I., 1832 Braun, T., 888 Bravo, R., 2340 Breitbart, R.E., 1783 Brill, S.J., 1332 Brock, H.W., 223 Brody, E., 497 Broker, T.R., 1131 Brown, D., 2152 Brown, P.O., 511 Brown, S.A., 2288 Brown, T.A., 2502 Bruder, J.T., 545 Brun, Y.V., 2395 Brunvand, M., 2201 Bulla, G.A., 316 Burke, J.M., 129 Busslinger, M., 1589 Butler, G., 93 Cairns, B.R., 1305 Callahan, R., 345 Campbell, S., 367 Carey, M., 1716 Carlson, L.L., 2536 Carlson, M., 1707 Carpousis, A.J., 149 Carr, A.M., 2035 Carroll, S., 2606 Cassano, S., 1621 Casselton, L.A., 568 Cedar, H., 705 Chadwick, R.B., 2165 Chaillet, J.R., 1843 Chalker, D.L., 117 Chambard, J.-C., 676 Chandler, V.L., 864, 2152 Charron, J., 2248 Chase, J.W., 2010 Chasman, D.I., 296 Chellappan, S.P., 177 Chen, C.-H., 655, 745 Chen, L., 81 Cheng, J., 1444 Cheng, N., 223 Chiao, P., 2352 Chittenden, T., 953 Chovnick, A., 367 Chow, A.M., 1950 Chow., L.T., 1131 Chu, E., 345 Chua., N.-H., 2364 Chuhjo, T., 2066 Citron, M., 2409 Clark, C.D., 2288

Clayton, D.A., 1975 Cleary, M.A., 2058 Cleary, M.L., 1608 Cleveland, D.W., 1927 Clyman, 1-, 1269 Cohen, B., 715 Cohen, S.M., 715 Colbert, T., 1940 Cole, C.N., 1173 Cole, M.D., 166 Coleman, T.A., 745 Colgan, 1., 304 Collins, S.J., 2258 Cone, K.C., 864 Conlon, R.A., 691 Cook, A., 1810 Copeland, N.G., 1832 Corces, V.G., 1865 Cortese, R., 316 Cowie, A., 481 Cross, F.R., 1695 Croston, G.E., 2270 Cullen, B.R., 2077 D'Evelyn, D., 2125 Dahlberg, I.E., 1097 Datum, K., 2258 Dang., C.V., 81 Darrow, A.L., 1202 Dawid, I.B., 356 de la Pompa, J.L., 14 DeArmond, S.J., 1213 DeCamillis, M., 223 DeGregori, J.V., 919 DeLoia, J.A., 1190 Demeter, L.M., 1131 DePinho, R.A., 1480 DeRobertis, E.M., 591 DeSimone, V., 316 Dickinson, L.K., 2312 Dickson, B., 2327 Dillon, N., 1857 Dirksen, M.L., 599 Dohrmann, P.R., 93 Dollard, S.C., 1131 Donahue, T.F., 2463 Donovan, P.J., 1832 D6rfler, P., 1589 Dorland, S., 93 Dubendorff, 1., 2524 Duckett, C.S., 2352 Dulic, V., 1874 Dunlap, J.C., 2382 Dvir, A., 426 Dynan, W.S., 426 Eaton, S., 2635 Ehretsmann, C.P., 149 Eisenman, R.N., 71 Eisenmann, D.M., 1319 Eltman, 1., 2524 Emerson, B.M., 521 Emori, Y., 50, 1005 Emory, S.A., 135 Engel, J.D., 161, 730 Enoch, T., 2035

Epner, E.M., 928 Eppig, J.J., 1832 Epstein, C.B., 1695 Errede, B., 1293 Evans, R., 2258 Evans, R.M., 329, 578 Faha, B., 1874 Falb, D., 454 Fangman, W.L., 380 Feder, J.H., 1402 Feliciello, A., 1621 Ferguson-Smith, A.C., 1843 Femandez-Sarabia, M.J., 2417 Firtel, R.A., 38 Fisher, P., 2248 Flanagan, P.M., 296 Foley, K.P., 730 Fong, T.C., 521 Forrester, W., 1914 Forrester, W.C., 928 Foumier, R.E.K., 316 Frank, D., 2112 Franke, A., 1241 Frederickson, R.M., 1631 Fresco, L.D., 1386 Friedel, C., 919 Friedman, P.N., 1886 Fuchs, E., 1444 Fujii, M., 2066 Fujita, T., 775 Furlong, D., 2646 Furukubo-Tokunaga, K., 1082 Furuya, M., 2364 Gallahan, D., 345 Gallo, A., 1621 Garbi, C., 1621 Gartner, A., 1280 Gaubatz, S., 568 Gauss, G.H., 1553 Gehring, W.J., 1030, 1082 German, M.S., 2165 Gershon, P.D., 1575 Geyer, P.K., 1865 Ghosh, S., 775 Giardina, C., 2190 Gillis, S., 61 Gilmore-Herbert, M., 1120 Glazer, L., 1668 Goff, S.A., 864 Goff, S.P., 2248 Gold, L., 497 Goldstein, A.L., 1173 Gomer, R.H., 390 Good, P.J., 356 Gorham, B.I., 2429 Gottesman, M.E., 1621 G6ttgens, B., 568 Gottschling, D.E., 197 Grabowski, P.J., 2554 Gralla, J.D., 1716 Graves, B.J., 975 Green, S.R., 2478 Greene, I.R., 93 Gregoriades, A., 568

GENES & DEVELOPMENT 2669

Gross, C.A., 1165 Grossman, S.R., 105 Grossniklaus, U., 1030 Grosveld, F., 1857 Groudine, M., 928, 2201 Grunstein, M., 411 Gualberto, A., 815 Guarente, L., 2001 Gunther, C.V., 975 Guo, Q., 1357 Guthrie, C., 2112 Habener, J.F., 439 Hadwiger, J.A., 38 Hafen, E., 2327 Hahn, S., 1940 Halfter, U., 2364 Hanahan, D., 2340 Handel, M.A., 1832 Harm, S.R., 1229 Hannah, L.C., 609 Hardy, C.F.J., 801 Harlow, E., 1874 Haskill, S., 1899 Hassell, J.A., 481 Hattori, T., 609 Hecker, R., 1213 Heidecker, G., 545 Henze, M., 2021 Hermans-Borgmeyer, I., 578 Herr, W., 2058 Herranz, A.B., 129 Herrick, D.J., 642 Heyman, R., 329, 2258 Hiebert, S.W., 177 Higashijima, S.-i., 50, 1005 Hirschhom, J.N., 2288 Hoekstra, M.F., 578 Hoffman, B.E., 2554 Holmgren, R.A., 161 Hopewell, R., 2429 Hopkins, N., 1 Horowitz, J.M., 177 Hunger, S.P., 1608 Hunter, T., 578 Ikawa, Y., 1821 Inamdar, M., 367 Ip, Y.T., 1518, 1728 Ishimaru, S., 50 Isoda, K., 619 Isshiki, T., 2455 Iwasaki, H., 2214 Izban, M.G., 1342 Jackson-Grusby, L., 29 Jaeger, L., 1373 Jain, R., 390 Jamrich, M., 356, 599 Jan, L.Y., 2137 Jan, Y.N., 1503, 2137 Jantzen, H.-M., 1950 JaramiUo, M.L., 1631 Jeannotte, L., 2248 Jegalian, B.G., 591 Jen, Y., 1466 Jendroska, K., 1213 Jenkins, N.A., 1832 Jhappan, C., 345

Johnson, D., 1190 Johnson, F.B., 2177 Johnson, L., 411 Jones, B.A., 380 Jones, P.A., 1843 Jonsen, M.D., 975 Joseph, S., 129 Joyner, A.L., 691,903 Ju, Q., 1332 Kadonaga, J.T., 1542, 2270 Kaelin Jr., W.G., 953 Kafri, T., 705 Kageyama, R., 2620 Kakizuka, A., 329, 578 Kalfayan, L.J., 233 Karin, M., 676 Kato, G.J., 81 Kato, H., 655 Kay, S., 2364 Kelleher III, R.J., 296 Kelsey, G., 1430 Kerckaert, J.-P., 965 Kerr, L.D., 2352 Kim, C.G., 928 Kim, Y.-J., 2569 King, D.S., 1950 Kingston, J., 1986 Kl/imbt, C., 1668 Klar, A.J.S., 186 Klement, J.F., 745 Kloter, U., 1082 Knowles, B., 1190 Kojima, T., 50 Kole, R., 631 Kolter, R., 2646 Kooyer, S., 2125 Komberg, R.D., 296, 1305,

2282 Komberg, T.B., 2635 Kosman, D., 1518, 1728 Kouzarides, T., 1810 Kozmik, Z., 1589 Kfiimer, A., 631 Kranz, R.G., 268 Krasnow, M.A., 2177 Kraus, K.W., 284 Krause, H.M., 1740 Kretzschmar, M., 761 Krisch, H.M., 149 Kristie, T.M., 2047 Krug, R.M., 255 Krumm, A., 2201 Kfies, U., 568 Kung, H.-f., 1631 Kuo, A., 29, 2513 Kuras, R., 1373 Lachance, P., 481 Lai, J.-S., 2058 Laimins, L.A., 105 Lambowitz, A.M., 1357 Lane, M.D., 533 Lane, W.S., 837 Laney, J.D, 1531 LaPointe, J.W., 2282 Laurent, B.C., 1707 Lauter, F.-R., 2373

2670 GENES & DEVELOPMENT

Laybourn, P.J., 2270 Lazaris-Karatzas, A., 1631 Leder, A., 2513 Leder, P., 29, 2513 Lee, B.-U., 401 Lee, G., 61 Lee, H.-s., 284 Lee, W.M.F., 81 Lee, Y., 1783 Lees, E., 1874 Lehmann, R., 2312 Lepesant, J.-A., 1019 Levine, A.J., 1143 Levine, M., 1518, 1728 Lew, D.J., 2021 Li, G., 761 Li, L., 676 Li, S., 401 Lieber, M.R., 1553 Lieberman, P.M., 1964 Lin, F.-T., 533 Lin, L., 1071 Lindahl, L., 2655 Lindquist, S., 1402 Link, A.J., 2646 Lipsick, J., 2524 Lis, J.T., 284, 2190 Liu, Y.-1., 1631 Livingston, D.M., 953 Loomis, W.F., 1058 Lorch, Y., 2282 Loros, J.J., 2382 Lowell, J.E., 2088 Lfihrmann, R., 631 Lund, E., 1097 Lfischer, B., 71 Luse, D.S., 1342 Lyman, S.D., 1832 Lynn, A.J., 788 Maddock, I.R., 825 Madore, S.J., 2077 Maeda, T., 2455 Mahdavi, V., 1783 Maher, M., 745 Malim, M.H., 2077 Malone, C., 2010 Malynn, B.A., 2248 Mangelsdorf, D.J., 329 Maniatis, T., 454, 466 Manley, J.L., 304, 1654, 2569 Manoukian, A.S., 1740 Marini, N.J., 557 Markiewicz, P., 2010 Matthews, M.B., 2478 Maurer-Fogy, I., 1589 McCarrey, J., 705 McCarty, D.R., 609 McGinnis, W., 1071 McGuffin, M.E., 715 McKeithan, T.W., 2352 McKnight, S.L., 2502 Meisler, M.H., 1457 Meisteremst, M., 761 Mendoza, G.E., 848 Merlino, G., 345 Messmer, S., 1241

Meulia, T., 2201 Meyer, E., 211 Michaud, S., 1986 Michel, F., 1373 Michiue, T., 50, 1005 Miller, B.L., 1770 Miller, K.Y., 1770 Miller, S.P., 2463 Milos, P.M., 991 Miner, J.N., 2491 Mitcham, J.L., 788 Mizuuchi, K., 2221 Mochizuki, N., 2455 Moens, C.B., 691 Montell, D.J., 2299 Moore, J., 2312 Morgenbesser, S.D., 1480 Morimoto, R.I., 1153 Morrow, M.A., 61 Moss, B., 1575 Muhlrad, D., 2100 Mukherjee, B., 1480 Mfiller, M., 1082 Murphy, S.P., 1153 Musti, A.M., 1621 Mutasa, E.S., 568 Myers, M.P., 1153 Nabel, G., 2352 Nadal-Ginard, B., 1783 Naeger, L.K., 1107 Nagatani, A., 2364 Nakanishi, S., 2620 Nakata, A., 2214 Nasmyth, K., 1280 Nawroz, M., 497 Nemeroff, M.E., 255 Nevins, J.R., 177 Nolan, G.P., 775 Norris, J.L., 1654 Nurse, P., 2035 Nfisslein-Volhard, C., 619 Nye, J.A., 975 O'Connell, M.L., 1202 OH, S.-K., 1643 Ohyashiki, K., 1608 Oliviero, S., 1799 Olson, E.N., 676 Ong, E.S., 329 Oro, A.E., 329 Pabich, E.K., 2463 Page, A.W., 2536 Page, B.D., 1414 Palazzolo, M., 367 Pan, K.-M., 1213 Panganiban, G., 2606 Parada, L.F., 2235 Paranjape, S.M., 2270 Park, A., 1493 Park, R.E., 1518, 1728 Parker, R., 2100 Parma, D.H., 497 Paro, R., 1241 Pastemak, D., 2592 Patrick, R.M., 815 Pearson, R.K., 1030 Pedersen, R.A., 939

Pepinsky, R.B., 105 P4rez-Riba, M., 2190 Perichon, R., 1019 Perkins, A.S., 2235 Perlman, J., 2125 Perrimon, N., 1503 Petersen, J.M., 975 Peterson, S.R., 426 Pfeifle, C., 715 Pick, L., 1082 Pierre, D., 223 Pintel, D.J., 1107 Pognonec, P., 655 Pomerantz, J.L., 2047 Ponticelli, A.S., 296 Posakony, J.W., 1752, 2592 Powell, P.A., 2592 Prakash, S.S., 105 Prendergast, G.C., 2429 Prescott, D.M., 788 Prives, C., 1143, 1886 Prokipcak, R.D., 642 Prusiner, S.B., 1214 Purton, T., 1562 Piischel, A.W., 591 Qin, X.-q., 953 Qiu, Y., 255 Radicella, J.P., 2152 Raghavan, V., 367 Ramer, S.W., 1305 Rapp, U.R., 545 Rappolee, D.A., 939 Rashid, D., 667 Raybum, H., 919 Razin, A., 705 Reddy, S., 919 Reed, R., 1986 Reed, S.I., 557, 1874, 2021 Reeder, R.H., 1332 Reichman, R.C., 1131 Reik, W., 1843 Resnick, J.L., 1832 Reynisdottir, I., 1886 Rhodes, N., 1293 Richardson, D.L., 1058 Richardson, H., 2021 Richardson, W.V.J., 568 Richter, J.D., 2580 Ricupero, S.L., 1319 Rio, D.C., 1386 Roberts, S., 1562 Robertson, E.J., 2248 Robinson, G.S., 1799 Rodrigues, V., 367 Roeder, R.G., 655, 761 Ron, D., 439 Rooney, J.W., 1319 Rosbash, M., 1914 Rose, L.S., 1255 Rosen, C.A., 655, 745, 1899 Rosenberg, M.P., 1457 Rosenkrans, L., 609 Ross, J., 642 Rossant, J., 1, 691 Rossi, J.M., 1402 Roth, M.B., 837

Roth, S., 619 Roth, S.Y., 411 Rothman-Denes, L.B., 2010 Rothstein, J.L., 1190 Ruben, S.M., 745, 1899 Rudner, D.Z., 2088 Ruley, H.E., 919 Ruppert, S., 1430 Russo, V.E.A., 2373 Rutledge, B.J., 1503 Rutter, W.J., 2165 RCrth, P., 2299 Sachs, A.B., 2088 Saga, Y., 1821 Saigo, K., 50, 1005 Sakakura, T., 1821 Salds, F.J., 1202 Samuelson, L.C., 1457 Sandmeyer, S.B., 117 Sandri-Goldin, R.M., 848 Sarnow, P., 1643 Sasai, Y., 2620 Sasaki, H., 1843 Sassoon, D.A., 2235 Savant-Bhonsale, S., 1927 Sawa, H., 244 Schedl, A., 1430 Scheidereit, C., 761 Scheinman, R.I., 1899 Schmid, E., 1430 Schmitt, M.E., 1975 Schoborg, R.V., 1107 Schreiber, H., 1444 Schultz, G.A., 939 Schultz, M.C., 1332 Schuster, H., 2409 Schfitz, G., 1430 Scott, M., 1213 Scott, M.P., 1643 Sebastian, B., 578 Segal, D., 715 S4galat, L, 1019 Seiki, M., 2066 Selegue, J., 2606 Shapiro, L., 825, 2395 Sharp, P.A., 2047 Shemer, R., 705 Shigemoto, R., 2620 Shilo, B.-Z., 1668 Shimizu, M., 411 Shimkets, L.J., 401 Shimura, Y., 244 Shinagawa, H., 2214 Shore, D., 801 Shub, D.A., 1373 Siebel, C.W., 1386 Simon, R., 2580 Simpson, R.T., 411 Singh, J., 186 Singson, A., 2592 Skames, W.C., 903 Skeath, J., 2606 Skowronski, J., 1190 Sloan-Brown, K., 1229 Smith, G.H., 345 Smith, M.R., 1631

Smoot, L.B., 1783 Snow, C.M., 1457 Snyder, M., 497, 1414 Sobolevski, S., 497 Solomon, J., 1402 Solomon, N., 1402 Solter, D., 1190 Sonenberg, N., 1631 Sontheimer, E.J., 2542 Spiegelman, B.M., 1799 Spotts, G.D., 1229 Spradling, A.C., 2443 Sprague Jr., G.F., 1293 Sprenger, F., 2327 Springer, M.L., 1052 Stahle, C., 345 Stanton, B.R., 2235 Steinhauer, W.R., 233 Steitz, J.A., 2542 Sternglanz, R., 1332 Stevenson, B.J., 1293 Stewart, V., 2248 Stillman, D.J., 93 Stockhaus, J., 2364 Stolk, J.A., 837 Strickland, S., 1202 Strouboulis, J., 1857 Struhl, K., 296, 1799 Sturm, K.S., 939 Stutz, F., 1914 Sugimoto, K., 2021 Sumimoto,.H., 655 Surani, M.A., 1843 Sussel, L., 801 Sutherland, J.A., 1810 Sutton, A., 2417 Tabata, T., 2635 Tagawa, Y., 2620 Taira, M., 356 Takahagi, M., 2214 Tamai, K., 93 Taphouse, C.R., 390 Taraboulos, A., 1213 Tassan, J.-P., 2580 Teng, M., 1444 Tessarollo, L., 2235 Thiele, D.J., 93 Thies, E., 1430 Tihy, F., 1373 Tiley, L.S., 2077 Ting, C.-N., 1457 Tjian, R., 1493, 1950 Tolar, L.A., 2152 Torchia, M., 1213 Toyama, K., 1608 Trawick, D.R., 268 Trumpp, A., 14 Tsai, S., 2258 Tsuchihashi, Z., 511 Tsuchiya, H., 2066 Tullis, G.E., 1107 Turcotte, B., 2001 Turksen, K., 1444 Tymon, A.M., 568 Ulrich, E., 876 Urb~inek, P., 1589

Urven, L., 705 Utans, U., 631 Vaessin, H., 2137 Van Doren, M., 2592 Vasil, I.K., 609 Vasil, V., 609 Verma, I.M., 667, 2352 yon Melchner, H., 919 Walker, K., 1143 Walsh, K., 815 Wampler, S.L., 1542 Wamsley, P., 2352 Wang, C., 2312 Wang, J., 2165 Wang, W., 1716 Wasylyk, B., 965 Wasylyk, C., 965 Wegner, J., 591 Weintraub, H., 1466 Werb, Z., 939 Westerfield, M., 591 Westhof, E., 1373 Whittaker, L., 2524 Wickens, M., 1914 Wieschaus, E., 1255 Wild, J., 1165 Wilson, J.L., 1131 Winston, F., 1319, 2288 Wisdom, R., 667 Wolfner, M.F., 284 Wright, J.H., 197 Wu, J., 1770 Wyatt, J.R., 2542 Xin, J.-H., 481 Xu, M.-Q., 1373 Yagi, T., 1821 Yamamoto, K.R., 2491 Yamamoto, M., 2455 Yancopoulos, G.D., 61 Yang, S.-L., 1213 Yang, X.W., 1120 Yanofsky, C., 1052, 2373 Yazdanbakhsh, K., 1518 Yen, J., 667 Yoon, H., 2463 Younger-Shepherd, S., 2137 Yu, Q.-C., 1444 Yu, Y.-T., 1783 Yue, L., 2443 Yuen, I.S., 390 Yura, T., 1165 Zahler, A.M., 837 Zakian, V.A., 197 Zambetti, G.P., 1143 Zaret, K.S., 991 Zeller, R., 14 Zengel, J.M., 2655 Zhang, K., 1503 Zhang, Q., 2352 Zhao, Q., 1107 Zhong, T., 2417 Zhou, J.Y., 329 Zhou, Q., 1964 Ziff, E.B., 2429 Zuo, P., 2569

GENES & DEVELOPMENT 2671

Subject Index, Volume 6 (1992)

Abdomen formation, Drosophila, role of Pumilio and Nanos activity (Barker et al.), 2312-2326

Abscisic acid (ABA), maize seed matura- tion, C1 gene activation (Hat- tori et al.), 609--618

ACE2, yeast transcriptional activator (Dohrmann et al.), 93-104

achaete (ac) Drosophila gene auto- and cross-regulatory activities

antagonized by emc gene (Van Doren et al.), 2592-2605

controlled by axis patterning genes (Skeath et al.), 2606-2619

Acidic activation domain, of VP16 (Tiley et al.), 2077-2087

Acidic activator, GAL4-AH (Wang et al.), 1716-1727

Activation domain, conserved motifs in Fos and lun (Sutherland et al.), 1810-1819

Activator region, cell-type-specific, of c-Jun (Baichwal et al.), 1493- 1502

Adducin, role in Drosophila life cycle (Yue and Spradling), 2443-2454

Adenovirus E la protein, inhibition of myogenic differentiation (Braun et al.), 888-902

Adh gene Drosophila and man, conserved regu-

latory unit (Falb and Maniatis), 454-465

fat body-specific enhancers, CREB/ ATF binding to (Abel et al.), 466-480

Adipocyte-specific genes, transcription activation by C/EBP (Lin and Lane), 533-544

AEF-1, competitive binding with C/EBP (Falb and Maniatis), 454-465

Albino-deletion complex, mice (Ruppert et al.), 1430-1443

Albumin promoter, mouse liver tissue, transcription complexes on (Mi- los and Zaret), 991-1004

alf/hsdr-I region, lethal albino mice (Ruppert et al.}, 1430-1443

Allelic diversity, of maize B regulatory gene (Radicella et al.), 2152- 2164

oq-Antitrypsin gene, extinction of (Bulla et al.), 316-327

a 2 repressor, and nucleosome position- ing (Roth et al.), 411-425

Alternative pre-mRNA splicing, model for mechanism (Siebel et al.), 1386-1401

Alternative splicing Drosophila otu transcript (Steinhauer

and Kalfayan), 233-243

mediated by group I intron core (Michel et al.), 1373-1385

mouse ld locus (Jackson-Grusby et al.}, 29-37

3' splice site choice in yeast (Frank and Guthrie), 2112-2124

U1 snRNP interaction with 3' splice site factor U2AF65 (Hoffman and Grabowski), 2554-2568

Amino acid (methionine) deprivation, and translational control (Hann et al.), 1229-1240

Ankyrin repeats, of GABPB, interaction with GABPa (Brown and Me- Knight), 2502-2512

Antennapedia mRNA, Drosophila ho- meotic gene, internal ribosome binding (OH et al.I, 1643-1653

Anthocyanin biosynthesis, maize seed maturation

(Hattori et al.), 609--618 pigmentation pathway, maize (Goff et

al.), 864-875 production, distinct tissue specifici-

ties determined by allelic diver- sity of maize B gene (Radicella et al.), 2152-2164

Antirepressor, product of ant gene in bacteriophage Pl and P7, syn- thesis repressed by c4 gene product (Biere et al.), 2409-2416

Antisense inhibition, immI region of bacteriophages Pl and P7 (Biere et al.), 2409-2416

AP-I binding site, of oncogene-responsive

element (Bruder et al.}, 545-556 family of regulatory proteins, c-Jun

(Baichwal et al.), 1493-1502 interaction with glucocorticoid recep-

tor at composite receptor ele- ment (Miner and Yamamoto), 2491-2501

transcription factors, and cellular transformation (Oliviero et al.), 1799-1809

Aspergillus nidulans, cell pattern forma- tion and StuA gene (Miller et al.), 1770-1782

Attenuation E. coli S10 operon (Zengel and Lin-

dahl), 2655--2662 N-myc (Morrow et al.), 61-70

Attenuation/termination. See Termina- tion/attenuation.

Autogenous control mechanism, E. coli r-protein L4 regulates S10 op- eron (Zengel and Lindahl), 2655-2662

AUUUA motifs, and mRNA instability (Savant-Bhonsale and Cleve- land), 1927-1939

Avian cells, telomere binding-protein MF3 (Gualberto et al.), 815-824

Axis formation, X. laevis, blastopore lip-

specific gene IDirksen et al.), 599--608

-patterning genes, Drosophila [Skeath et al.), 2606-2619

B

B-cell differentiation, BSAP expression (Adams et al.I, 1589-1607

b-HLH proteins, Drosophila, interaction with dl morphogen (Ip et al.), 1728-1739

Bacteriophage h, Rex-mediated cell death (Parma et al.}, 497-510

Bacteriophage T4 gene 32, RNase E's role in mRNA pro-

cessing (Ehretsmann et al.), 149-159

sunY intron (Michel et al.), 1373-1385 Bacteriophages P1 and P7, antisense in-

hibition in immI region (Biere et al.), 2409-2416

Bar homeo box genes, Drosophila X chromosome, BarH1 and BarH2 (Higashijima et al.}, 1005--1018

Bar region, Drosophila eye development, dual homeo box genes (Higashi- jima et al.), 50-60

Basic helix-loop-helix proteins, Droso- phila ac and sc (Van Doren et al.), 2592-2605

bcl-3 proto-oncogene, encodes IKB pro- tein (Kerr et al.), 2352-2363

13-globin gene

chick, role of erythroid-specific en- hancer binding factor cGATA-1 {Fong et al.), 521-532

human, homologous recombination into LCR (Kim et al.), 928-938

locus, human, developmental regula- tion of in transgenic mice (Stouboulis et al.), 1857-1864

bHLH domain, of Myf-5, target of inhibition

by Ela (Braun et al.), 888-902 motif, maize transcriptional activa-

tors, B and R (Golf et al.), 864- 875

Bicoid (bcd) morphogen, and stripes in Drosophila embryo (Ip et al.), 1728-1739

Biogenesis, bacterial cytochrome c (Beckman et al.}, 268-283

Biphasic effect, of Max on Myc cotrans- formation activity (Prendergast et al.), 2429-2439

Blastopore lip, Xenopus, axis formation (Dirksen et al.), 599--608

Blue light inducible gene, N. crassa, bli-7 is eas gene (Lauter et al.), 2373- 2381

Bovine papillomavirus transgenic mice,

2672 GENES & DEVELOPMENT

fibrosarcoma development {Bos- sy-Wetzel et al.), 2340-2351

Branch migration, promoted by RuvA- RuvB interaction with Holliday junction (Iwasaki et al.), 2214- 2220

breathless (btl), Drosophila FGF receptor homolog, and cell migration (Kl~imbt et al.), 1667-1678

BRF1, a TFIIB-related factor involved in RNA Pol III transcription (Col- bert and Hahn), 1940-1949

BSAP, paired domain transcription fac- tor, homology between mouse and man (Adams et al.), 1589- 1607

Budding yeast, Saccharomyces cerevi- siae, in vivo DNA methylation by foreign methylases as probe for chromatin structure (Singh and Klar), 186-196

bZIP fusion protein, Hlf, altered proper- ties in acute leukemia (Hunger et al.), 1608-1620

C

C signal, CsgA gene product entrains Myxococcus development (Li et al.), 401-410

c-Jun, cell-type-specific activator region, two regulatory domains {Baich- wal et al.), 1493-1502

c-Myb, carboxy-terminal elements of, negative regulation (Dubendorff et al.), 2524-2535

c-myc modulating action, gene target of

(ECA39) (Benvenisty et al.), 2513--2523

regulatory interaction with N-myc (Stanton et al.), 2235-2247

mRNA, stability (Bernstein et al.), 642-654

see also myc gene. c-Myc, hetero-oligomerization to Max

required for function {Kato et al.), 81-92

c-rnyc (human) gene expression, block- ing of transcriptional elongation (Krumm et al.), 2201-2213

c-myc 1, translational activation of (Hann et al.), 1229-1240

C/EBP competitive binding with AEF-1 (Falb

and Maniatis), 454--465 contains HOB2 activation domain

{Sutherland et al.), 1810-1819 Drosophila and mammalian, func-

tional and structural similarity (RCrth and Montell), 2299-2311

mechanism of action (Milos and Za- ret), 991-1004

role of during differentiation of 3T3-L 1 preadipocytes (Lin and Lane), 533-544

transcription factor, CHOP inhibits function (Ron and Habener), 439-453

C1 complex, HSV, Oct-1 POU domain is recognized by VP16 (Pomerantz et al.), 2047-2057

c4 antisense repressor, transcriptional control via translational repres- sion {Biere et al.), 2409-2416

Cachexia, and TNFa expression in trans- genie mice (Cheng et al.), 1444- 1456

cAMP production, and S. pombe gpa2 gene (Isshiki et al.), 2455-2462

Carboxy-terminal domains, role in nega- tive regulation (Dubendorff et al.), 2524-2535

CArG boxes, of p67 sRF binding factor, in- teraction with Taxi {Fujii et al.), 2066-2076

Casein kinase II (CKII), Max DNA-bind- ing activity inhibited {Berberich and Cole), 166-176

Caulobacter polar localization of chemoreceptor

(Alley et al.), 825-836 polar morphogenesis and cell division,

sigma s4 required (Brun and Sha- piro), 2395-2408

cdc25 homolog, mouse, Cdc25M2 (Kak- izuka et al.), 578-590

Cdc28 kinase, activation of by Clb pro- teins {cyclin-B homologs)(Rich- ardson et al.), 2021-2034

cDNA libraries, preimplantation mouse development (Rothstein et al.), 1190-1201

Cds28 kinase, Saccharomyces cerevi- siae, transcriptional activation of Gl-specific genes (Marini and Reed), 557-567

Cell cycle cyclin E/E2F association (Lees et al.),

1874-1885 Saccharomyces cerevisiae, cyclin-B

homologs function in S phase and in G 2 (Richardson et al.], 2021-2034

S. pombe, checkpoint genes (Enoch et al.), 2035-2046

Cell death, Rex-mediated (Parma et al.), 497-510

Cell fate, Drosophila eye development (Higashijima et al.),

5O-60 H gene controls SOP cell fate (Bang

and Posakony), 1752-1769 Cell growth, aberrant induction of

HTLV-1 immediate early genes {Fujii et al.), 2066-2076

Cell migration, Drosophila, role of FGF receptor homolog (breathless) (Klfimbt et al.), 1667-1678

Cell-type-specific activator region, c-Jun, two regulatory domains (Baich- wal et al.}, 1493--1502

Cellular transformation, and GCN4 and AP- 1 transcription factors {Oliv- iero et al.), 1799-1809

Cellularization, Drosophila, hullo gene (Rose and Wieschaus), 1255- 1268

Chaperones, SecB, E. coli protein export (Wild et al.), 1165-1172

Checkpoint genes, S. pombe, coupling of mitosis to completion of DNA replication (Enoch et al.), 2035- 2046

Chemoreceptor, bacterial, polar localiza- tion of {Alley et al.), 825-836

Chicken cell lines, immortalization (Ul- rich et al.], 876-887

Chicken limb deformity (ld) gene, nu- clear proteins encoded by {Trumpp et al.), 14-28

CHOP, nuclear protein, dominant-nega- tive inhibitor of transcription (Ron and Habener), 439--453

Chromatin binding, role of Pc chromo domain

(Messmer et al.), 1241-1254 protein, encoded by Drosophila ph

gene (DeCamillis et al.I, 22,3- 232

structure budding yeast {Singh and Klar}, 186-

196 human ~-globin gene [Kim et al.),

928-938 and mRNA processing [Forrester et

al.1, 1914-1926 nucleosome positioning (Roth et

al.), 411--425 S. cerevisiae, alteration of by SNF

proteins (Laurent and Carlson), 1707-1715

S. cerevisiae, telomeric and subtelo- meric (Wright et al.), 187-210

and transcription (Hirschhom et al.), 2288-2298

and transcriptional activity (Croston et al.), 2270-2281

templates, transcription initiation in yeast RNA polymerase tran- scription system (Lorch et al.), 2282-2287

of mouse Igf2 gene, and parental im- printing (Sasaki et al.), 1843- 1856

Chromo domain, evolutionary conserva- tion (Messmer et al.), 1241- 1254

Chromosomal translocations, leukomo- genesis (Hunger et al.), 1608-1- 620

Chromosome segregation, yeast, genes involved in (Page and Snyderl, 1414-1429

CIK1, yeast, SPB-associated protein {Page and Snyder), 1414-1429

Circadian clock, N. crassa ccg-2 gene, in-

GENES & DEVELOPMENT 2673

teracting role with light (Bell- Pedersen et al.), 2382-2394

Clb proteins, cyclin-B homologs from yeast, role during mitosis (Rich- ardson et al.), 2021-2034

CLB5 novel B cyclin, Saccharomyces cerevisiae, role in S phase (Ep- stein and Cross), 1695-1706

CMF (conditional medium factor), Dic- tyostelium density-sensing mech- anism (Jain et al.), 390--400

Cofactors, interaction with yeast HAP1 DNA-binding domain (Turcotte and Guarente), 2001-2009

Coliphage N4, double-stranded DNA vi- rus, early promoter activation by supercoiling and SSB (Mark- iewicz et al.), 2010-2019

Composite response element, plfg, AP-1 and glucocorticoid receptor in- teraction (Miner and Ya- mamoto), 2491-2501

con gene expression, N. crassa sporula- tion pathway (Springer and Yanofsky), 1052-1057

Cone cell formation, Drosophila, dual Bar homeo box genes (Higashi- jima et al.), 50-60

Conidia, N. crassa (Lauter et al.), 2373- 2381

Conidiation, A. nidulans, cell pattern formation (Miller et al.), 1770- 1782

Conserved regulatory unit, Drosophila, Adh gene (Falb and Maniatis), 454-465

Coprinus cinereus, A mating-type gene complexes (Kfiues et al.), 568- 577

Couch potato {cpo) gene, Drosophila PNS functioning (Bellen et al.), 2125-2136

CREB/ATF transcriptional regulatory proteins, BBF-2 (Abel et al.), 466--480

CsgA gene product, Myxococcus devel- opment {Li et al.), 401-410

CTS1 gene, yeast, regulation by ACE2 {Dohrmann et al.), 93-104

Culmination, Dictyostelium sporulation (Richarson and Loomis), 1058- 1070

Cyclin E, association with E2F transcrip- tion factor (Lees et al.), 1874- 1885

Cyclin, S. cerevisiae, role of CLB5 in S phase (Epstein and Cross), 1695-1706

Cyclin-B homologs (Clb proteins, Sac- charomyces cerevisiae, func- tion in S phase and in G2 (Rich- ardson et al.), 2021-2034

Cyclin/kinase complexes, regulation of E2F during different phases of cell cycle (Lees et al.), 1874- 1885

Cytochrome c, bacterial biogenesis (Beckman et al.), 268-283

Cytoplasmic bridges (ring canals), Drosophila oo-

genesis (Yue and Spradling), 2443--2454

inhibitory protein, IKB, interaction with NLS of NF-KB {Beg et al.), 1899-1913

polyadenylation, regulation of murine maternal mRNAs (Sall4s et al.}, 1202-1212

retention, mechanism of action (Beg et al.}, 1899-1913

D

DAI, double-stranded RNA-activated protein kinase, RNA-binding motifs in (Green and Mathews), 2478-2490

Deadenylation of MFA2 yeast transcript (Muhlard and

Parker), 2100-2111 yeast, 3'-UTR-dependent (Lowell et

al.), 2088-2099 Dedifferentiation of thyroid cells, v-Ras

and PKC down-regulated nu- clear PKA {Gallo et al.), 1621- 1630

Deletional vs. inversional V(D)J recom- bination, (Gauss and Lieber), 1553-1561

Density-sensing mechanism, Dictyoste- lium (Jain et al.), 390--400

Developmental mutations, Paramecium primaurelia, microinjection of telomeric gene (Meyer), 211- 222

Developmental systems (Holmgren and Engel), 161-165 (meeting re- view)

Dfd homeotic protein, Drosophila, func- tional specificity (Lin and McGinnis), 1071-1081

Dictyostelium development, density-sensing factor

(Jain et al.), 390--400 G~ protein function (Hadwiger and Fir-

tel), 38-49 sporulation, disruption of and spore

instability (Richardson and Loomis}, 1058-1070

Dimerization, papillomavirus E2 protein (Prakash et al.), 105-116

DNA binding

activity, CKII inhibits Max ho- modimers (Berberich and Cole), 166-176

complex, GABP (Brown and Mc- Knight), 2502-2512

complex, Max:c-Myc (Kato et al.), 81-92

complex Myc:Max (Blackwood et al.), 71-80

domain, of AP-1 (Miner and Ya- mamoto), 2491-2501

element, wild-type p53-specific (Zambetti et al.), 1143-1152

and ets family members (Wasylyk et al.), 965-974

factor, terminator-binding factor {TBF I)(Roberts et al.), 1562- 1574

inhibition of wild-type p53 binding (Bargonetti et al.), 1886-1898

protein, C/EBP {RCrth and Montell), 2299-2311

protein, Dps, regulatory and protec- tive roles in starved E. coli (Almir6n et al.), 2646-2654

protein, papillomavirus E2 protein (Prakash et al.), 105-116

proteins, ets gene family (Nye et al.), 975-990

of Rel protein {Kerr et al.), 2352- 2363

melting, late step in transcription ini- tiation pathway {Wang et al.), 1716----1727

methylation in vivo, of yeast genes by foreign me-

thylases (Singh and Klar), 186- 196.

and parental imprinting of mouse Igf2 gene (Sasaki et al.}, 1843- 1856

see also methylation. methyltransferase (DNA MTase), in

preimplantation mouse em- bryos (Carlson et al.), 2536- 2541

processing, O. nova gene scrambling (Mitcham et al.}, 788-800

repair, yeast, role of SSL1 gene product {Yoon et al.), 2463-2477

replication, completion of coupled to mitosis, role of fission yeast genes IEnoch et al.), 2035-2046

synapsis, molecular mechanism of (Adzuma), 1679-1694

transposition, phage Mu (Baker and Mizuuchi), 2221-2232

virus, coliphage N4 [Markiewicz et al.), 2010-2019

DnaJ heat shock protein, role in E. coli protein export (Wild et al.), 1165-1172

DnaX gene, E. coli, translational frame- shifting {Tsuchihashi and Brown), 511-519

Dominant interference, Myc/Max onco- genie mechanisms (Mukherjee et al.), 1480-1492

Dominant-negative activity, mutant RAR~ against normal

RAR~ (Tsai et al.), 2258-2269 inhibitor (CHOP), of transcription fac-

tors of C/EBP and LAP (Ron and Hbener), 439-453

2674 GENES & DEVELOPMENT

Dorsal (dl) Drosophila morphogen nuclear transport established by sig-

naling pathway (Norris and Manley), 1654-1667

functional domains of (Isoda et al.), 619-630

initiates rhomboid (rho) stripes (Ip et al.), 1728-1739

dorsal-twist interaction, Drosophila mesoderm, snail gene expres- sion (Ip et al.), 1518-1530

Dorsal-ventral, polarity, Drosophila em- bryo, nuclear transport of dl {Norris and Manley), 1654-1667

Dorso-ventral axis formation, Droso- phila, role of spitz gene {Rut- ledge et al.), 1503-1507

Double-stranded RNA -activated protein. See DAI. and activation of DAI {Green and

Mathews), 2478-2490 Dps DNA-binding protein, regulatory

and protective roles in starved E. coli (Almir6n et al.), 2646- 2654

Drosophila abdomen formation, role of Pumilio

and Nanos activity {Barker et al.), 2312-2326

Adh gene, conserved regulatory unit within man (Falb and Maniatis), 454--465

C/EBP, functional and structural sim- ilarity to mammalian C/EBP (Rerth and Montell), 2299-23 11

cell migration, role of breathless (btl), an FGF receptor homolog {KIambt et al.), 1667-1678

cellularization, hullo gene (Rose and Wiecschaus), 1255-1268

dorsal morphogen initiates rhomboid stripes {Ip et al.),

1728-1739 nuclear transport (Norris and Man-

Icy), 1654-1667 external sensory (es) organs, subtype

determination (Higashijima et al.), 1005-1018

eye development, prepattern in (Dick- son et al.), 2327-2339

ftz homeo domain, helix-turn-helix motif (Furukubo-Tokunago et al.), 1082-1096

hairy and Enhancer of split, rat HLH proteins HES-1 and HES-3 are structurally related to (Sasai et al.), 2620-2634

homeo box genes, dual Bar genes (Hi- gashijima et al.), 50--60

homeo domain functional specificity (Lin and McGinnis), 1071-1081

hsp70 expression at normal tempera- ture {Feder et al.), 1402-1413

mesoderm, doral-twist interactions, snail gene expression (Ip et al.), 1518-1530

nonessential zeste gene, activates Ubx promoter (Laney and Biggin), 1531-1541

oogenesis, hts gene encodes homolog of adducin (Yue and Spradling}, 2443-2454

ovarian development, otu mutations (Steinhauer and Kalfayan), 233- 243

P-element splicing iSiebel et al.), 1386-1401

Pc chromo domain, functional role of (Messmer et al.), 1241-1254

pair-rule gene eve protein functions as concentration-dependent mor- phogen (Manoukian and Krause), 1740-1751

pan-neural gene (dpn) with HLH motif (Bier et al.), 2137-2151

PNS, couch potato protein, homology to RNA-binding proteins {Bel- len et al.), 2125-2136

polyhomeotic gene (ph), encodes chro- matin protein (DeCamillis et al.), 223-232

position-specific transcriptional re- pression (Geyer and Corces), 1865-1873

pqp gene is wings down {WDN) gene (S4galat et al.), 1019-1029

preIC assembly, differential regulation of by UBX and EVE (Johnson and Krasnow), 2177-2189

promoter-paused RNA pol II (Giardina et al.), 2190-2200

proneural gene expression (Skeath et al.), 2606-2619

relationship between engrailed (en) and hedgehog (hh) (Tabata et al.), 2635-2645

RNA polymerase pausing on hsp70 (Lee et al.), 284-295

RNA-binding protein RBP1, func- tional similarity to human splicing factor ASf/SF2 (Kim et al.), 2569-2578

scalloped (SD) gene encodes evolu- tionarily conserved transcrip- tion factor {Campbell et al.), 367-379

sensory organ development, Hairless gene (H), protein controls alter- native cell fate (Bang and Posa- kony), 1752-1769

sloppy paired locus, segmentation (Grossniklaus et al.), 1030-1051

spitz gene, encodes putative EGF-like growth factor {Rutledge et al.), 1503-1507

TFIID-promoter interactions {Colgan and Manley), 304-315

transcription factor IIB {dTFIIB) (Warn- pier and Kadonaga), 1542-1552

transcriptional activator, CREB/ATF family (Abel et al.), 466-480

wing imaginal disc, spatial patterning

of proneural clusters (Van Doren et al.), 2592-2605

Dynamin, GTP-binding domain {Jones and Fangman}, 380-389

E proteins, association with Id, inhibi- tion of muscle differentiation (Jen et al.), 1466-1479

E2a gene, chromosomal translocations in acute leukemias {Hunger et al.), 1608-1620

E2F transcription factor and RB {Qin et al.), 953-964 association with cyclin E [Lees et al.I,

1874-1885 interaction with pRB {Hiebert et al.),

177-185 eas N. crassa gene

allelism with ccg-2 (Bell-Pedersen et al.), 2382-2394

structural gene for the rodlet protein (Lauter et al.), 2373-2381

ECA39 gene, target gene of c-Myc regu- lation (Benvenisty et al.), 2513- 2523

eIF-4E-induced transformation, medi- ated by Ras signaling pathway {Lazaris-Karatzas et al.), 1631- 1642

Elongation factor SII, facilitates transcript cleavage

{Izban and Luse), 1342-1356 TFIIF, interaction with Tat {Kato et

al.), 655-666 Embryogenesis

Drosophila, C/EBP required for devel- opment (Rerth and Montell), 2299-23 11

(Holmgren and Engel), 161-165 {meet- ing review)

mouse, DNA methylation {Kafri et al.), 705-714

TN-deficient mice develop normally (Saga et al.), 1821-1831

Embryonal stem cells, gene disruption by promoter trap vectors (yon Melchner et al.), 919-927

Embryonic development, vertebrate, mutational

analysis of (Rossant and Hop- kins), 1-13 {Review)

lethality, loss of N-myc function (Charron et al.), 2248-2257, (Stanton et al.], 2235-2247

stem (ES) cells, gene trap approach in {Skames et al.}, 903-918

Endoribonuclease RNase E, E. coli, specificity of (Ehrets-

mann et al.), 149-159 RNase MRP, nuclear role of (Schmitt

and Clayton), 1975-1985 engrailed {en) Drosophila gene, regulates

expression of hh {Tabata et al.), 2635-2645

GENES & DEVELOPMENT 2675

Enhancer of split [E(spl)], Drosophila, rat HLH proteins HES-1 and HES-3 are structurally related to (Sasai et al.}, 2620-2634

Enhancer-binding factors, counteract chromatin-mediated repression (Croston et al.}, 2270-2281

Enhancers. See also Promoter-enhancer interaction.

Epidermal growth factor [EGF), Droso- phila spitz gene encodes puta- tive homologous protein (Rut- ledge et al.), 1503-1507

Escherichia coli branch migration, promoted by RuvA

and RuvB proteins (Iwasaki et al.), 221 4-2220

endoribonuclease RNase E, specificity of (Ehretsmann et al.}, 149-159

mRNA stabilization by 5'-stem-loop structure (Emory et al.), 135-148

N4 early transcription, single-stranded DNA-binding protein (SSB) re- quired for (Markiewicz et al.), 2010-2019

protein export, role of heat shock pro- teins DnaK and DnaJ {Wild et al.), 1165-1172

RecA protein, mediates stable DNA synapsis (Adzuma), 1679-1694

S10 operon, regulation by ribosomal protein L4 {Zengel and Lindahl), 2655-2662

translational frameshifting, dnaX gene (Tsuchihashi and Brown), 511- 519

ets family members, different trans-acting

properties of {Wasylyk et al.), 965-974

oncogene family, new member PEA3 (Xin et al.), 481-496

-related proteins, two newly defined proteins (ER81 and ER71) (Brown and McKnight), 2502- 2512

ets-1 proto-oncogene, eukaryotic tran- scriptional regulator (Nye et al.}, 975-990

Ets -binding site, of oncogene-responsive

element (Bruder et al.), 545-556 transcription activation by (Wasylyk

et al.), 965-974 ETS

domain, specificity of DNA binding (Nye et al.), 975-990

family, DNA-binding and protein-pro- tein interaction specificity (Brown and McKnight), 2502- 2512

even-skipped (eve} pair-rule gene, Drosophila, Eve func-

tions as concentration depen-

dent morphogen (Manoukian and Krause), 1740-1751

Drosophila, homeo domain protein EVE (Johnson and Krasnow), 2177-2189

Evolution of gene regulation, role for ret- rotransposition (Ting et al.), 1457-1465

Evolutionary conservation transcription factors (Campbell et al.),

367-379 vertebrate limb pattern formation

{Trumpp et al.), 14-28 Exon

definition, effect of nonsense muta- tions on (Naeger et al.), 1107- 1119

selection, positive regulation by U1 snRNP/U2AF65 communica- tion {Hoffman and Grabowski), 2554-2568

Exonucleases, 5'-3' and 3'-5' (Ctyman and Belfort), 1269-1279

External sensory (es) organs, Drosophila, subtype determination (Higash- ijima et al.), 1005-1018

Extinction, of a~-antitrypsin gene ex- pression (Bulla et al.), 316-327

Extracellular matrix protein, normal de- velopment of TN-deficient mice (Saga et al.), 1821-1831

extramacrochaetae (emc) Drosophila gene, role in controlling spatial pattern of ac and sc transcrip- tion (Van Doren et al.), 2592- 2605

Eye development, Drosophila, dual Bar homeo box genes (Higashijima et al.), 50-60

F

Fibroblast growth factor (FGF) receptor, Drosophila, analysis of ho- molog (breathless)(Kl~imbt et al.), 1667-1678

Fibrosarcoma development, functional role of transcription factors JunB and c-Jun (Bossy-Wetzel et al./, 2340-2351

Fission yeast checkpoint genes, coupling of mitosis to completion of DNA replication (Enoch et al.), 2035--2046

5' splice site, site-specific cross-linking of mammalian U5 snRNP to (Wyatt et al.), 2542-2553

Flagelllum biosynthesis, Caulobacter, role of r factor (Brun and Sha- piro), 2395-2408

fork head domain Drosophila, novel putative DNA-bind-

ing domain (Grossniklaus et al.), 1030-1051

Xenopus, blastopore lip-specific gene (Dirksen et al.), 599-608

Formins, ld alternatively spliced tran- script protein products (Jack- son-Grusby et al.), 29-37

Fos and muscle transcription, repression

of (Li et al.), 676-689 oncoprotein, HOB motifs of (Suther-

land et al.), 1810-1819 see also oncoproteins

FosB protein, transactivation domain missing in FosB2 (Wisdom et al.), 667--675

FosB2 protein, lacks transactivation do- main present in FosB (Wisdom et al.), 667--675

Fumaryl acetoacetate hydrolase, gene for within al[/hsdr-1 region, lethal albino mice (Ruppert et al.), 1430--1443

Fungal spore development, interacting role of light and circadian clock (Betl-Pedersen et al.), 2382-2394

FUS3 kinase, phosphorylation of, S. cere- visiae (Gartner et al.}, 1280- 1292

fushi tarazu (ftz) homeo domain, Droso- phila, helix-turn-helix motif {Furukubo-Tokunago et al.), 1082-1096

G

G protein Dictyostelium, Ga4 subunit analysis of

(Hadwiger and Firtel), 38--49 S. pombe, gpa2 gene encodes Ga sub-

unit involved in nutrional mon- itoring (Isshiki et al.), 2455- 2462

G-G base pair recognition, avian telom- eres {Gualberto et al.), 815-824

GABa, target site selection by (Brown and McKnight}, 2502-2512

GAGA factor, role in RNA polymerase pausing in heat shock gene (Lee et al.), 284-295

GAL4-VP16 mediated antirepression, of histone HI-mediated repression (Croston et al.), 2270-2281

GALII, as possible HAP1 cofactor {Tur- cotte and Guarente), 2001-2009

GATA-1, promoter-enhancer interac- tions regulated by (Fong et al.), 521-532

Gene scrambling, O. nova (Mitcham et al.),

788-800 targeting, partial loss-of-function mu-

tations (Moens et al.), 691-704 trap vector, mouse embryonic stem

cells (Skarnes et al.), 903-918 Genome reorganization, Paramecium,

polyploid macronucleus from diploid nucleus (Meyerl, 211-222

2676 GENES & DEVELOPMENT

Genomic imprinting embryonic development {Rappolee et

al.), 939-952 preimpantation mouse embryos (Carl-

son et al.), 2536-2541 Germ cell development, role of SLF

(Brannan et al.), 1832-1842 Globin gene switching, promoter compe-

tition (Foley and Engel}, 730-744

Glucocorticoid response element, inter- action with AP-1 (Miner and Yamamoto), 2491-2501

Granulocyte monocyte colony stimulat- ing factor (GM-CSF) AU com- plex, and mRNA instability (Sa- vant-Bhonsale and Cleveland), 1927-1939

Group I intron, activation of catalytic core (Michel et al.), 1373-1385

Group I introns, splicing of and similar- ity to tRNAs (Guo and Lam- bowitz), 1357-1372

Growth suppression domain, within RB gene product (Qin et al.), 953- 964

Gl-specific genes, dependency on Cdc28 kinase activation {Marini and Reed), 557-567

GTP-binding domain, dynamin D100 (Jones and Fangman), 380-389

G 1 regulation, of S. cerevisiae, role of SIT4 gene (Femandez-Sarabia et al.), 2417-2428

H

hairless {H) Drosophila gene, protein controls SOP cell fate (Bang and Posakony), 1752-1769

Hairy (h) Drosophila, rat HLH proteins HES-1

and HES-3 are structurally re- lated to {Sasai et al.), 2620-2634

gene product, Drosophila, pan-neural gene {dpn) closely related to (Bier et al.), 2137-2151

Half-life, of c-myc mRNA {Bemstein et al.), 642-654

HAP1 activator, yeast, cofactor interac- tion (Turcotte and Guarente), 2001-2009

Heat shock genes

Drosophila, DNA melting of (Giar- dina et a1.),2190-2200

RNA polymerase pausing on hsp70 (Lee et al.), 284-295

proteins, DnaK and DnaJ, role in E. coli protein export (Wild et al.), 1165-1172

response, and splicing pathway (Utans et al.), 631-641

hsp70/HSF interaction (Abravaya et al.), 1153-1164

hedgehog Drosophila gene, target of en regulation {Tabata et al.), 2635- 2645

Helix-loop-helix (HLH) -bZIP, chimeric transcription factor

(Hunger et al.}, 1608-1620 -ZIP domain, Max:c-Myc heteromeric

complex (Kato et al.), 81-92 motif, Drosophila ftz homeo domain

(Furukubo-Tokunago et al.), 1082-1096

protein Drosophila emc {Van Doren et al.),

2592-2605 encoded by Drosophila dpn gene

(Bier et al.), 2137-2151 Id associates with E2A proteins (Jen

et al.), 1466--1479 and insulin (German et al.}, 2165-

2176 muscle-specific, myogenin and

MyoD {Li et al.), 676-689 rat HEAS-1 and HES-3, structural

homology to Drosophila hairy and Enhancer of split (Sasai et al.), 2620-2634

regulatory gene, maize B gene {Radi- celia et al.), 2152-2164

zipper protein, Max, association with Myc family proteins (Black- wood et al.), 71-80

Hematopoiesis {Holmgren and Engel), 161-165 (meeting review)

Heme transport, and bacterial cy- tochrome c biogenesis (Beck- man et al.), 268-283

Hemopoietic differentiation, role of RARa transcription factor (Tsai et al.), 2258-2269

Hepatic development, albumin gene ac- tivators {Milos and Zaret), 991- 1004

Heptapeptide repeats, of RNAP II CTD, phosphorylation of (Peterson et al.}, 426-438

Herpes simplex virus Oct-1 multiprotein complex {C1) (Po-

merantz et al.), 2047-2057 trans-activator VP16, association with

POU protein Oct-1 and Oct-2 (Lai et al.), 2058-2065

HES family, HLH factors, structurally re- lated to Drosophila h and E(spl) (Sasai et al.), 2620-2634

Heteromeric complex, Max:c-Myc (Kato et al.), 81-92

Hexagonal actin-myosin network, Dro- sophila hullo gene stabilizes (Rose and Wiecschaus), 1255- 1268

Histone Hi-mediated repression, counteracted

by GAL4--VP 16 hybrid activator (Croston et al.), 2270-2281

H4, and nucleosome positioning (Roth et al.), 411--425

HIV- 1 promoter, transcription regulation by

NF-KB {Kretzschmar et al.), 761-774

VP 16 and Tat have functionally inter- changeable activation domains (Tiley et al.), 2077-2087

HMG box protein, hUBF (Jantzen et al.), 1950-1963

HO endonuclease gene, yeast, regulated by SW15 (Dohrmann et al.), 93- 104

Holliday junction, E. coli protein com- plex RuvA-RuvB interaction, promotes branch migration {Iwasaki et al.), 2214-2220

Homeo box -containing genes {HOX), promoter ac-

tivation in transgenic zebrafish {Westerfield et al.), 591-590

gene, Xlim-1 in X. laevis LIM domain {Taira et al.}, 356-366

genes, Drosophila Bar region and eye development (Higashijima et al.}, 50-60

Homeo domain ftz Drosophila, helix-turn-helix motif

(Furukubo-Tokunago et al.), 1082-1096

motifs, Coprinus, A mating type gene complexes (Kiies et al.), 568-577

proteins Drosophila activator UBX and re-

pressor EVE {Johnson and Kras- now), 2177-2189

Oct-1 POU, recognition of surface {Pomerantz et al.), 2047-2057

Homeo domains, Dfd and Ubx, mapping functional specificity {Lin and McGinnis), 1071-1081

Homeobox genes, redundant, Drosophila BarH1 and BatH2 (Higashijima et al.), 1005-1018

Homeotic complex HOM-C, Drosophila, map-

ping functional specifity in Dfd and Ubx (Lin and McGinnis), 1071-1081

Drosophila gene, Antp, intemal ribo- some binding of mRNA (OH et al.), 1643-1653

genes Drosophila repression by Polycomb

group {PcG) (DeCamillis et al.), 223-232

Drosophila Ubx promoter activation {Laney and Biggin), 1531-1541

Homologous recombination branch migration in (Iwasaki et al.),

2214-2220 mto human 13-globin LCR (Kim et al.),

919-927 role of recA protein during DNA syn-

apsis {Adzuma}, 1679-1694

GENES & DEVELOPMENT 2677

HPV production, in epithelial raft cul- tures (Dollard et al.), 1131-1142

HSF, interaction with hsp70 (Abravaya et al.), 1153-1164

hSL1, TBP-TAF complex, interaction with hUBF activation domain (Jantzen et al.), 1950-1963

Hsp70, Drosophila, consequences of ex- pression at normal temperature (Feder et al.), 1402-1413

HSV- 1 regulatory protein, ICP27, affects mRNA processing (Sandri-Gol- din and Mendoza), 848-863

HTLV-1, Tax1 transcriptional activator and transforming protein (Fujii et al.), 2066-2076

hu-li-tai shao (hts), Drosophila gene, en- codes adducin homolog {Yue and Spradling), 2443-2454

hUBF activation domains, cooperative interactions with TBF-TAF complex hSL1 (Jantzen et al.), 1950-1963

Human hsp70 protein, interaction with HSF

{Abravaya et al.), 1153-1164 papillomavirus. See HPV. salivary amylase gene (AMY1C}, tis-

sue-specific expression, retrovi- ral sequences required for (Ting et al.I, 1457-1465

splicing factor ASF/SF2, Drosophila RNA binding protein RBP1 shows functional similarity to (Kim et al.), 2569-2578

Human/Mel hybrid, human B-globin LCR (Kim et al.), 928-938

Hybrid cells (hepatoma/fibroblast), ex- tinction of liver specific oq-AT gene (Bulla et al.), 316-327

Hydrophobin encoded by N. crassa ccg-2 gene (Bell-

Pedersen et al.), 2382-2394 gene family, N. crassa eas gene is

member of (Lauter et al.), 2373- 2381

I

ICP27, HSV-1 regulatory protein, post- transcriptional effect on mRNA processing (Sandri-Goldin and Mendoza), 848-863

Id HLH protein, associates with E2A pro- tein, inhibition of muscle differ- entiation (Jen et al.), 1466-1479

IKB protein family, bcl-3 and IKB~ are members of (Kerr et al.), 2352- 2363

Imaginal disc development, Drosophila, apterous (ap) gene (Cohen et al.), 715-729

Immediate early genes, HTLV-1, aber- rant induction of (Fujii et al.}, 2066--2076

immI region of bacteriophages P1 and

P7, novel antisense system (Biere et al.), 2409-2416

Immortalization, of chicken cells, as dis- tinct from cell transformation (Ulrich et al.), 876-887

In vitro selection, of hairpin ribozymes (Berzal-Herranz et al.l, 129-134

Influenza virus, nucleocytoplasmic transport of mRNA (Alonso-Ca- plen et al.), 255-267

Insulin I rat gene, minienhancer com- plex (German et al.), 2165-2176

Insulin receptors, preimplantation mouse embryos (Rappolee et al.), 939-952

Insulin-like growth factor IGF-II/IGF-I receptor pathway in

mouse embryos {Rappolee et al.), 939-952

II (Igf2), mouse, parental imprinting (Sasaki et al.), 1843-1856

Integration sites, of Ty3 retrovirus-like element (Chalker and Sandm- eyer), 117-128

Interleukin-7 (IL-7), N-rnyc and C-myc regulation in pre-B lymphocytes (Morrow et al.), 61-70

Internal eliminated sequences, O. nova, removal of (Mitcham et al.), 788-800

Intron core, binding by tyrosyl-tRNA synthe-

tase (Guo and Lambowitz), 1357-1372

mobility, trans and cis requirements (Clyman and Belfort), 1269- 1279

Jun family of oncogenes, fibrosarcoma de-

velopment (Bossy-Wetzel et al.), 2340-2351

and muscle transcription, repression of (Li et al.), 676-689

oncoprotein, HOB motifs of (Suther- land et al.), 1810-1819

see also oncoproteins

K

Karyogamy, yeast, genes involved in (Page and Snyder), 1414--1429

Keratinocyte, differentiation {Dollard et al.), 1131-1142

Keratinocytes, TNF~ production (Cheng et al.), 1444-1456

Kidney development, chicken ld gene (Trumpp et al.}, 14-28

Kinase cascade, role in pheromone response

pathway (Stevenson et al.), 1293-1304

double-stranded RNA-activated pro- tein kinase (DAI), RNA-binding

motifs in (Green and Mathews), 2478-2490

Kinases, S. cerevisiae FUS3, STEll, and STE7 (Gartner et

al.), 1280-1292 STE7 and STE11 (Cairns et al.), 1305-

1318 KMnO4, as probe for single-stranded

DNA (Giardina et al.), 2190-- 2200, {Krumm et al.), 2201- 2213

L

LacZ gene expression, TN-deficient mice,

lacZ replaces TN (Saga et al.), 1821-1831

reporter, mouse ES cells, and gene trap vector (Skames et al.), 903-918

LAP, transcription factor, CHOP inhib- its function (Ron and Habener), 439-453

Leukemogenesis, chromosomal translo- cations, oncogenic conversion by transcription factors (Hunger et al.), 1608-1620

LIM domain, Xenopus laevis homeo box

gene Xlim-1 (Taira et al.), 356- 366

gene family, Drosophila, ap gene (Co- hen et al.}, 715--729

-homeo domain protein, and insulin minienhancer complex (Ger- man et al.I, 2165-2176

Limb development, chicken ld gene (Trumpp et al.), 14-28

Locus control region (LCR), human f~-globin gene, homologous re- combination into (Kim et al.), 919-927

Lung branching morphogenesis, mouse, role for N-myc {Moens et al.), 691-704

M

Macronuclear destined sequences (MDS), O. nova,

reordering and splicing (Mitcham et al.), 788-800

development, Paramecium primaure- lia, telomere addition sites (Meyer), 211-222

MADS gene family, MEF2 factors are members of (Yu et al.), 1783- 1798

Maize anthocyanin pigmentation pathway

(Goff et al.), 864-875 B regulatory gene, allelic diversity of

(Radicella et al.}, 2152-2164 seed maturation, VP 1 activation of the

C1 gene (Hattori et al.), 609-618

2678 GENES & DEVELOPMENT

Male sterility, resulting from activated int-3 transgenic mice (Jhappen et al.), 345-355

Mammary glands, lactation deficiency, resulting from activated int-3 locus (Jhappen et al.), 345-355

Masked mRNA, X. laevis, activation of by cytoplasmic poly(A) elonga- tion (Simon et al.), 2580-2591

Maternal effect genes, Drosophila pumilio and

nanos (Barker et al.), 2312-2326 morphogen, Drosophila dorsal (dl) (Ip

et al.), 1728-1739 mRNAs, murine, regulated by cyto-

plasmic polyadenylation {Sall6s et al.), 1202-1212

Mating type, Coprinus A gene com- plexes (Ktiues et al.), 568-577

Max homodimer, DNA-binding activity in-

hibited by CKII (Berberich and Cole), 166-176

protein biphasic effect of on Myc cotransfor-

mation activity (Prendergast et al.), 2429-2439

functional domains of and interac- tion with c-Myc (Kato et al.), 81-92

helix-loop--helix zipper protein, asso- ciation with Myc family pro- teins (Blackwood et al.), 71-80

interaction with Myc proteins (Mukherjee et al.), 1480-1492

MCK (muscle creatine kinase)gene, identification of wild-type p53 responsive element {Zambetti et al.), 1143-1152

McpA chemoreceptor, C. crescentus, po- lar localization of (Alley et al.}, 825-836

Methylation gene-specific, mouse development

(Kafri et al.), 705-714 patterns, preimplantation mouse em-

bryos (Carlson et al.), 2536- 2541

MF3 protein, specificity for single stranded telomere probes (Gual- berto et al.), 815-824

MFA2 yeast gene decay and deadenylation of mRNA

(Muhlard and Parker), 2100- 2111

3'-UTR-dependent deadenylation of RNA (Lowell et al.), 2088-2099

MGM1, S. cerevisiae, mitochondrial ge- nome maintenance gene (Jones and Fangman), 380-389

Mice normal development of TN-deficient

mice (Saga et al.), 1821-1831 splicing defect in Steel ~ zH {Brannan et

al.), 1832-1842

Microtubule -binding protein, dynamin D100 (Jones

and Fangman), 380--389 function, S. cerevisiae gene involved

in (Page and Snyder), 1414-1429 Midblastula transition, X. laevis, tran-

scription activation (Lund and Dahlberg), 1097-1106

Minienhancer complex, components of (German et al.), 2165-2176

Mitochondrial DNA (mtDNA), nuclear genes re-

quired for maintenance (Jones and Fangman), 380-389

RNA processing, tyrosyl-tRNA syn- thetase (Guo and Lambowitz}, 1357-1372

RNA, RNase MRP (Schmitt and Clay- ton), 1975-1985

Mitosis coupled to completion of DNA repli-

cation, role of fission yeast genes (Enoch et al.), 2035-2046

yeast, role of cyclin-B homologs {Clb proteins) (Richardson et al.), 2021-2034

Mitotic control, mammalian cells, mouse cdc25 homolog (Kaki- zuka et al.), 578-590

MMTV, integration into int-3 locus acti- vated Notch-related flanking se- quences {Jhappen et al.), 345-355

Mouse cdc25 homolog, developmental ex-

pression (Kakizuka et al.), 578- 590

embryogenesis function of N-myc during (Stanton

et al.), 2235-2247, (Charron et al.), 2248-2257

regulatory role of PEA3 (Xin et al.], 481--496

embryos, endogenous growth pathway (Rappolee et al.), 939-952

limb deformity {ld) locus, alternatively spliced transcripts of (Jackson- Grusby et al.), 29-37

insulin-like growth factor (Igf2) gene, parental imprinting (Sasaki et al.), 1843-1856

mRNA degradation

specificity of RNase E (Ehretsmann et al.), 149-159

yeast, deadenylation of MFA2 tran- script (Muhlard and Parker), 2100-2111

export, Saccharomyces cerevisiae, RAT1 gene (Amberg et al.), 1 1 7 3 - 1 1 8 9

instability, and GM-CSF AU complex (Savant-Bhonsale and Cleve- land), 1927-1939

processing affected by HSV-1 regulator (San&i-

Goldin and Mendoza), 848-863 defects of in prp20 yeast mutation

{Forrester et al.), 1914-1926 stability

c-myc [Bemstein et al.), 642-654 E. coli, 5'-stem-loop structure (Em-

ory et al.I, 135-148 nucleocytoplasmic transport, influ-

enza virus (Alonso-Caplen et al.), 255-267

MuA tetramer, DNA promoted assem- bly of (Baker and Mizuuchi}, 2221-2232

Murine mammary tumor virus. See MMTV

Muscle differentiation, inhibition of, Id association with E proteins (E2A) (Jen et al.), 1466--1479

Muscle transcription, repression of by Fos and Jun (Li et al.), 676-689

Muscle-specific gene regulation, MEF2 factors are members of MADS family (Yu et al.), 1783-1798

Mutagenic strategies, vertebrate {Ros- sant and Hopkins), 1-13 (Re- view)

Mutant p53 protein, inhibits wild-type p53 binding {Bargonetti et al.), 1886-1898

myc gene expression, IL-7 regulated {Morrow et

al. ), 61-70 family, regulatory interaction between

c-myc and N-myc {Stanton et al.l, 2235-2247

Myc cotransformation, biphasic effect of

Max on (Prendergast et al.I, 2429-2439

family proteins, common transforma- tion pathways including Max interaction (Mukherjee et al.), 1480-1492

Myc:Max, sequence-specific DNA-bind- ing complex (Blackwood et al.), 71-80

Myc/Max heterodimers, DNA-binding activity, unaffected by CKII {Berberich and Cole), 166-176

Myocyte-specific enhancer factors 2 (MEF2), members of MADS box family (Yu et al.), 1783--1798

MyoD, muscle-specific HLH protein (Li et al.), 676-689

Myogenic differentiation, inhibition of by adenovirus Ela protein (Braun et al.), 888-902

Myogenin, muscle-specific HLH protein (Li et al.), 676--689

Myxococcus xanthus, csgA expression entrains development {Li et al.), 401--410

GENES & DEVELOPMENT 2679

N

N-myc gene

function of during mouse embryo- genesis and regulatory interac- tion with c-myc (Stanton et al.), 2235-2247

physiological function distinct from other myc genes (Charron et al.), 2248-2257

role in mouse lung development (Moens et al.), 691-704

see also myc gene N4. See also coliphage N4 Negative regulation, by c-Myb carboxy-

terminal element (Dubendorff et al.), 2524-2535

Nervous system, regulation of Hox ex- pression (Westerfield et al.), 591-598

Neural precursor cells, Drosophila (Bier et al.),

2137-2151 tube, dorsoventral polarity and

chicken ld gene products (Trumpp et al.), 14-28

Neurogenesis (Holmgren and Engel), 161-165 (meeting review)

Drosophila, role of spitz gene (Rut- ledge et al.}, 1503-1507

Neurogenic genes, Drosophila SOP cell fate, interaction with Hairless (H) gene (Bang and Posakony), 1752-1769

Neurospora crassa bli-7 gene is structural eas gene, en-

codes major rodlet protein (Lau- ter et al.), 2373-2381

clock-controlled gene ccg-2 allelic to eas gene (Bell-Pedersen et al.), 2382-2394

sporulation pathways, con gene ex- pression (Springer and Yanof- sky), 1052-1057

NF-KB transcription factor I-Rel inhibits activity {Ruben et al.),

730-744 pS0 and p65 subunits, independent

modes of activation (Fujita et al.), 775-787

pS0 subunit {Kretzschmar et al.), 761- 774

NF-KB, NLS/IKB interaction (Beg et al.), 1899-1913

Non-AUG initiation, translational acti- vataion of c-myc (Hann et al.), 1229-1240

Nonessential genes, Drosophila zeste ac- tivates Ubx transcription (Laney and Biggin), 1531-1541

Nonsense mutations, MVM RNA, inhi- bition of splicing (Naeger et al.), 1107-1119

NS1 protein, influenza virus regulates

nuclear export of RNA (Alonso- Caplen et al.), 255--267

Nuclear hormone receptors, RARs and RXRs

(Mangelsdorf et al.}, 329-344 import, U3 snRNA, molecular signals

for (Baserga et al.), 1120-1130 localization, of Max protein (Prender-

gast et al.), 2429-2439 localization sequences (NLS], of

NF-KB, interaction with IKB (Beg et al.), 1899-1913

protein, CHOP, dominant-negative in- hibitor of transcription {Ron and Hbener), 439-453

transport, Drosophila, dorsal protein {Norris and Manley), 1654-1667

Nucleocytoplasmic transport, influenza virus mRNA (Alonso-Caplen et al.), 255-267

Nucleosome positioning, by a2 repressor and histone H4 (Roth et al.), 411-425

Nucleosomes inhibit transcription initiation (Lorch

et al.), 2282-2287 yeast, as opposed to telosomes (Wright

et al.), 187-210 Nullo gene, Drosophila cellularization

{Rose and Wiecschaus), 1255- 1268

NusA transcription factor, E. coli S 10 op- eron, required to promote RNA polymerase pausing at termina- tion site (Zengel and Lindahl), 2655-2662

O

Oct-1 homeo domain, VP 16 association, role

of Glu-22 (Lai et al.), 2058-2065 POU domain, HSV, recognition of sur-

face (Pomerantz et al.), 2047- 2057

Oct-2 homeo domain, Glu-22 substitu- tion confers VP16 associations {Lai et al.), 2058-2065

Ommatidia development. See Eye devel- opment

ompA transcript, E. coli, 5'-untranslated region acts as stabilizer (Emory et al.), 135-148

Oncogene, myb (Dubendorff et al.), 2524--2535

Oncogenesis (Holmgren and Engel), 161- 165 {meeting review)

Oncogenic conversion, of bZIP protein Hlf {Hunger et al.), 1608-1620

Oncoproteins Fos and Jun, activation domain

(Sutherland et al.), 1810-1819 Jun and Fos {Oliviero et al.), 1799-

1809 Myc family (Mukherjee et al.), 1480-

1492 Oogenesis, Drosophila, role of otu

(Steinhauer and Kalfayan), 233- 243

Ovarian development, Drosophila pro- tein expression from otu (Stein- hauer and Kalfayan), 233-243

Oxidative stress, E. coli, Dps protects DNA (Almir6n et al.), 2646- 2654

Oxytricha nova, e~-telomere-binding pro- tein, (Mitcham et al.), 788-800

P-element splicing, Drosophila, mecha- nism regulating (Siebel et al.), 1386--1401

p50 subunit, of NF-KB (Kretzschmar et al.), 761-774

transcription factor (Fujita et al.), 775- 787

p53 gene product, naturally occuring wild-

type DNA-binding element (Zambetti et al.), 1143-1152

loss of during cell immortalization (Ulrich et al.), 876-887

protein, site-specific binding of (Bar- gonetti et al.), 1886-1898

p65 subunit, of NF-KB transcription fac- tor (Fujita et al.), 775-787

p67 sRr GaArG-binding factor, interac- tion with HTLV-1 Taxl, aber- rant induction of cell growth (Fujii et al.), 2066-2076

Pair-rule gene, Drosophila even-skipped {eve), Eve functions as

concentration-dependent mor- phogen [Manoukian and Krause}, 1740-1751

ftz (Furukubo-Tokunago et al.), 1082- 1096

and proneural gene expression (Skeath et al.), 2606-2619

Pair-rule locus, Drosophila, slp (Grossniklaus et

al.), 1030-1051 segmentation gene, Drosophila hairy

{h) (Sasai et al.), 2620-2634 Paired domain transcription factor,

BSAP encoded by Pax-5 gene (Adams et al.), 1589-1607

Pan-neural genes, Drosophila deadpan (dpn) encodes HLH protein (Bier et al.), 2137-2151

Papillomavirus, E2 protein, dimerization and DNA binding {Prakash et al.), 105-116

Paramecium prirnaurelia, induction of de- velopmental mutations (Meyer), 211-222

Parental imprinting, mouse insulin-like growth factor II (Igf2) (Sasaki et al.), 1843-1856

Parotid-specific expression, human sali- vary amylase gene AMY1C (Ting et al.), 1457-1465

2680 GENES & DEVELOPMENT

Parvovirus minute virus of mice (MVM), nonsense mutations inhibit splicing (Naeger et al.), 1107- 1119

Pattern formation A. nidulans, stuA gene required

{Miller et al.), 1770-1782 Drosophila

slp genes (Grossniklaus et al.), 1030- 1051

wing imaginal disc (Van Doren et al.), 2592-2605

vertebrate, mouse limb development (lackson-Grusby et al.), 29-37

X. laevis gastrula embryos, role of X//rn-I gene (Taira et al.), 356- 366

Pax-5 gene, encodes paired domain tran- scription factor BSAP {Adams et al.), 1589-1607

PEA3, Ets oncogene family, regulatory role during mouse embryogene- sis (Xin et al.), 481-496

Peripheral nervous system development, Drosophila, couch potato (cpo) gene (Bellen et al.), 2125-2136

Phage T4, td intron (Clyman and Bel- fort), 1269-1279

Pheromone response pathway, S. cerevisiae

components order of action (Cairns et al.), 1305-1318

kinase cascade {Stevenson et al.), 1293-1304

signal transduction pathway, S. cerevi- siae (Gartner et al.), 1280-1292

Phosphorylation of FUS3 kinase, S. cerevisiae (Gartner

et al.), 1280-1292 of Max homodimers (Berberich and

Cole), 166-176 and RB gene product (Qin et al.), 953-

964 of RNAP II CTD heptapeptide repeats

(Peterson et al.), 426--438 yeast signal transduction, of STE7 ki-

nase (Cairns et al.), 1305-1318 Photoreceptor, phytochrome A (phyA)

(Stockhaus et al.), 2364-2372 Phytochrome A (phyA), structure/func-

tion relationship, serine-to-ala- nine substitutions {Stockhaus et al.), 2364-2372

Pigment cell formation, Drosophila, dual Bar homeo box genes (Hi- gashijima et al.), 50--60

PNS. See Peripheral nervous system Polarity, bacterial chemoreceptor {Alley

et al.), 825-836 Poly(A)

elongation, X. laevis development, translational control by {Simon et al.), 2580-2591

nuclease {PAN), yeast tail degradation {Lowell et al.}, 2088-2099

tail length, regulates polyadenylation

{Gershon and Moss), 1575-1586 yeast, shortening of by PAN is 3'-

UTR dependent {Lowell et al.), 2088-2099

Polyadenylation regulated by poly(A) tail length (Ger-

shon and Moss), 1575-1586 X. laevis embryogenesis, identifica-

tion of novel cytoplasmic cis- acting element {Simon et al.), 2580-2591

Polycomb chromo domain, Drosophila, reequired for chromatin binding (Messmer et al.), 1241-1254

Polycomb group (PEG) genes, Droso- phila, ph and Pc interaction (DeCamillis et al.), 223-232

polyhorneotic gene (ph), Drosophila, en- codes chromatin protein (De- Camillis et al.), 223-232

Polymerase II transcription, stimulated by acidic activator GAL4-AH and TFIIA and IID (Wang et al.), 1716-1727

Polyomavirus enhancer, oncogene-re- sponsive element (Bruder et al.), 545-556

Positive control mutants, of yeast HAP1 activator (Turcotte and Gua- rente}, 2001-2009

Post-transcriptional regulation, HSV-1 regulatory protein ICP27 (San- dri-Goldin and Mendoza), 848- 863

POU domain, of Oct-1 (Pomerantz et al.), 2047-2057

and Oct-1 (Lai et al.), 2058-2065 pqp gene, Drosophila zinc finger protein,

oocyte nucleus localization (S6galat et al.), 1019-1029

Pre-mRNA splicing shutdown resulting from heat shock

(Utans et al.), 631-641 site-specific cross-linking prior to

{Wyatt et al.), 2542-2553 SR proteins, conserved family (Zahler

et al.}, 837-847 U6 snRNA as catalytic element in

spliceosome (Sawa and Shi- mura), 244-254

Pre-mRNAs, processing of, role of Drosophila rpbl gene (Kim et al.), 2569-2578

Precursor B lymphocytes, IL-7-regulated myc gene expression {Morrow et al.), 61-70

Preimplantation mouse development

gene expression during {Rothstein et al.), 1190-1201

imprinted genes influence develop- ment (Rappolee et al.), 939-952

embryos, localization of DNA MTase {Carlson et al.), 2536--2541

Preinitiation complex (prelC), Droso- phila, differential regulation of by UBX and EVE (Johnson and Krasnow}, 2177-2189

Prepattem, in Drosophila developing eye (Dickson et al.), 2327-2339

Prespliceosomes, protein components of (Bennet et al.), 1986-2000

Prions, replication of in transgenic mice and hamsters (Hecker et al.), 1213--1228

Processivity factor, in vitro, HIV-1 Tat (Kato et al.), 655-666

Promoter -binding factors, counteract chroma-

tin-mediated repression (Cros- ton et al.), 2270--2281

competition, globin gene switching {Foley and Engel), 730-744

melting, on Drosophila genes in vivo (Giardina et al.), 2190-2200

trap vectors, ES cells, gene disruption (yon Melchner et al.), 919-927

Promoter-enhancer interaction, 13-globin gene, regulation

by GATA-1 (Fong et al.), 521- 532

competition, LCR function and globin gene switching (Kim et al.), 928-938

Promoters, RNA polymerase II, TFIID interaction (Colgan and Man- ley), 304-315

Proneural gene expression, Drosophila {Skeath et al.), 2606-2619

Protein export, E. co//, role of heat shock pro-

teins DnaK and DnaJ {Wild et al.), 1165-1172

kinase, DNA dependent, signal for phosphorylation (Peterson et al.), 426--438

kinase A (PKA), down-regulation by v-Ras and PKC (Gallo et al.), 1621-1630

kinase C (PKC), down-regulates nu- clear PKA (Gallo et al.), 1621- 1630

phosphatase SIT4, S. cerevisiae late G~, required for normal accu- mulation of SWI4 (Fernandez- Sarabia et al.), 2417-2428

sequestration, Drosophila hsp70 {Feder et al.), 1402-1413

Protein-DNA complexes, tetramer of Mu trans-

posase {MuA) {Baker and Mi- zuuchi), 2221-2232

interactions, insulin minienhancer complex (German et al.), 2165- 2176

Protein-protein interaction at composite response elements

{Miner and Yamamoto), 2491- 2501

GENES & DEVELOPMENT 2681

and maize anthocyanin pigmentation pathway (Goff et al.), 864-875

recognition of surface of Oct-1 POU homeo domain {Pomerantz et al.), 2047-2057

TBF-TAF complex hSL1 (Jantzen et al.), 1950-1963

VP16 association with Oct-1 vs Oct-1 (Lai et al.), 2058-2065

Proto-oncogene N-myc, mouse lung development

(Moens et al.), 691-704 Raf-1, activation by serum, TPA and

Ras (Bruder et al.), 545-556 see also individual genes

Proto-oncogenes junB and c-jun, fibrosarcoma develop-

ment (Bossy-Wetzel et al.), 2340-2351

see also individual genes prp20 yeast mutants, defects in mRNA

processing (Forrester et al.), 1914-1926

R

R7 cell development, Drosophila {Dick- son et al.), 2327-2339

Raf-1, activation by serum, TPA and Ras {Bruder et al.}, 545-556

Raft culture, production of HPV (Dollard et al.), 1131-1142

RAPl-interacting factor (RIF1), mediator for RAP1 (Hardy et al.), 801-814

Ras cotransformation assays, biphasic ef-

fect of Max on Myc {Prendergast et al.I, 2429-2439

signaling pathway, and eIF-4E-induced transformation (Lazaris-Karat- zas et al.), 1631-1642

Rat HLH proteins HES-1 and HES-3, struc-

tural homology to Drosophila hairy and Enhancer of split (Sa- sai et al.), 2620-2634

insulin I gene, minienhancer complex (German et al.), 2165-2176

RAT1 yeast gene, mRNA export (Am- berg et al.), 1173-1189

RBP1, Drosophila RNA-binding protein, pre-mRNA processing (Kim et al.), 2569-2578

RecA protein, E. coli, mediates stable synapsis of homolog DNA (Ad- zuma), 1679-1694

Recombinases, RecA and UvsX (Clyman and Belfort), 1269-1279

Recombination pathway, intron mobil- ity (Clyman and Belfort), 1269- 1279

Redundancy, Drosophila, and regulation of Ubx and other genes (Laney and Biggin), 1531-1541

Rel protein

family, I-Rel inhibits NF-KB tran- scriptional activity (Ruben et al.), 745-760

DNA-binding activity of (Kerr et al.), 2352-2363

transcription factors, Drosophila dl morphogen (Isoda et al.), 619-630

Repressor/activator protein 1 {RAP1), yeast, activity at silencers and telomeres (Hardy et al.), 801-814

Retinoblastoma gene (Rb), expression of during immor-

talization (Ulrich et al.), 876-887

susceptibility gene RB, growth suppression domain

within (Qin et al.), 953-964 RB1, E2F-pRB interaction (Hiebert

et al.), 177-185 Retinoic acid receptor

rAR systems as compared to RXR fam- ily (Mangelsdorf et al.), 329-344

transcription factor (RARa), role in he- mopoietic differentiation (Tsai et al.), 2258-2269

Retrotransposition, and evolution of gene regulation (Ting et al.), 1457-1465

Retrotransposon Ty3, preferential inser- tion of {Chalker and Sandm- eyer), 117-128

Retroviral sequences, required for tissue- specific expression, human sali- vary amylase gene (Ting et al.), 1457-1465

Retrovirus, promoter trap vectors (U3His and U3Neo) (yon Melch- ner et al.), 919-927

Rev protein of HIV-1, RNA-binding do- main of (Tiley et al.), 2077-2087

Rex system, bacteriophage lambda, cell death (Parma et al.), 497-510

rho-dependent termination, and c4 RNA controlled expression of the ant gene {Biere et al.), 2409-2416

Rhodobacter capsulatus, cytochrome c biogenesis (Beckman et al.), 268-283

Rhomboid (rho} expression, Drosophila embryo, stripes regulated by dl (Ip et al.), 1728-1739

Ribonuclease, PAN and mRNA degrada- tion (Lowell et al.), 2088-2099

Ri~bosomal protein L4, E. coli, regulation of S10 operon (Zengel and Lin- dahl), 2655-2662

Ribozyme core, group I introns (Michel et al.),

1373-1385 hairpin, in vitro selection of (Berzal-

Herranz et al.), 129-134 Ring canals. See Cytoplasmic bridges

RNA -binding

factor, Drosophila RMP1, functional similarity to human splicing factor ASf/SF2 (Kim et al.), 2569-2578

motifs, in DAI (Green and Mathews), 2478-2490

protein, Drosophila cpo shows ho- mology to (Bellen et al.}, 2125- 2136

cleavage reaction, hairpin ribozyme {Berzal-Herranz et al.), 129-134

Pol I factor hUBF, activation domains of {Jantzen et al.), 1950-1963

polymerase, of N4 DNA virus (Mark- iewicz et al.), 2010-2019

polymerase II Drosophila, analysis of dTFIIB

(Wampler and Kadonaga}, 1542- 1552

elongation of [Kato et al.), 655--666 heptapeptide repeats, phosphoryla-

tion of (Peterson et al.), 426-438 holo-THID complex {Zhou et al.),

1964-1974 promoters, TATA-TFIID interac-

tions {Colgan and Manley), 304- 315

SII-dependent transcript truncation (Izban and Luse), 1342-1356

transcription initiation on chroma- tin templates {Lorch et al.}, 2282-2287

transcription termination (Roberts et al.), 1562-1574

transcriptional antirepression by GAL4-VP16 (Croston et al.), 2270-2281

polymerase III transcription, and TH1B-related fac-

tor BRF1 (Colbert and Hahn), 1940-1949

Ty3 integrates within transcription initiation region (Chalker and Sandmeyer), 117-128

polymerase pausing Drosophila genes, promoter melting

(Giardina et al.),2190-2200 hsp70, DNA requirements of (Lee et

al.), 284-295 promoter-proximal, and block to

transcriptional elongation (Krumm et al.), 2201-2213

processing RNase E's role in T4 and E. coli

mRNA degradation {Ehrets- mann et al.), 149-159

RNase MRP RNA, nuclear role of enzyme {Schmitt and Clayton), 1975-1985

-protein interactions, exon-bridging model (Hoffman and Grabowski), 2554-2568

recognition motif (RRM), isolation and characterization of rpbl Droso-

2682 GENES & DEVELOPMENT

phila gene (Kim et al.), 2569- 2578

structure, 5'-stem-loop structure sta- bilizes E. coli mRNA (Emory et al.), 135-148

trafficking, RatlP/Seplp homology (Amberg et al.), 1173-1189

-RNA interactions, sunY intron (Michel et al.), 1373-1385

RNase MRP RNA, yeast/mammal ho- mology, nuclear role of enzyme (Schmitt and Clayton), 1975- 1985

Rodlet layer, N. crassa, ccg-2 gene encodes

hydrophobin required for (Bell- Pedersen et al.), 2382-2394

protein, N. crassa (Lauter et al.), 2373- 2381

rpoN Caulobacter gene, and normal cell division (Brun and Shapiro), 2395-2408

rRNA transcription, negative supercoil- ing and topoisomerase activity (Schultz et al.), 1332-1341

RuvA-RuvB protein complex, E. coli, in- teraction with Holliday junc- tion promotes branch migration (Iwasaki et al.), 2214--2220

RXR gene family, ligand specificity and expression (Mangelsdorf et al.), 329-344

S

S phase, S. cerevisiae, role of CLBS-a novel B cyclin (Epstein and Cross), 1695-1706

Saccharomyces cerevisiae Cdc28-dependent transcriptional acti-

vation (Marini and Reed), 557- 567

cyclin-B homologs function in S phase and in G 2 (Richardson et al.), 2021-2034

mitochondrial genome maintenance gene (Jones and Fangman), 380- 389

pheromone response pathway, kinase cascade (Stevenson et al.), 1293- 1304

prp20 mutation, defects in mRNA pro- cessing (Forrester et al.), 1914- 1926

RAT1 gene, mRNA export (Amberg et al.), 1173-1189

RNA levels of G1 cyclins (Fernandez- Sarabia et al.), 2417-2428

RNase MRP RNA, mammalian ho- mology (Schmitt and Clayton), 1975-1985

S phase, role of CLB5-a novel B cyclin (Epstein and Cross), 1695-1706

see also yeast signal transduction, phosphorylation

of FUS3 kinase {Gartner et al.), 1280-1292

spindle pole body and microtubule function (Page and Snyder), 1414-1429

telomeres, assume non-nucleosomal chromatin structure (Wright et al.), 187-210

telomeric and subtelomeric chromatin (Wright et al.), 187-210

3' splice site selection (Frank and Guthrie), 2112-2124

transcription, SPT3 interaction with TFIID (Eisenmann et al.), 1319- 1331

transcriptional activators, SNF pro- teins, GAL4, and Bicoid (Lau- rent and Carlson), 1707-1715

translation initiation and UV resis- tance, role of SSL1 gene product (Yoon et al.), 2463-2477

Salivary amylase gene human, parotid- specific expression (Ting et al.), 1457-1465

Scalloped (sd) gene, Drosophila sensory organ differentiation, evolution- arily conserved transcription factor (Campbell et al.), 367-379

Schizosaccharomoyces pore be checkpoint genes (Enoch et al.), 2035-

2046 nutritional monitoring and cAMP pro-

duction (Isshiki et al.), 2455- 2462

Scrapie prions, replication of (Hecker et al.), 1213-1228

scute (sc) Drosophila gene auto-and cross-regulatory activities

antagonized by emc gene (Van Doren et al.), 2592-2605

controlled by axis patterning genes (Skeath et al.), 2606-2619

SecB, chaperone, E. coli protein export (Wild et al.), 1165-1172

Segment polarity gene en, Drosophila, directly activated by

Eve (Manoukian and Krause), 1740-1751

Drosophila hedgehog {hh), target of en- grailed (en) regulation (Tabata et al.), 2635-2645

Segmentation Drosophila, slp locus (Grossniklaus et

al.), 1030-1051 pair-rule gene eve, Eve functions as

concentration dependent mor- phogen (Manoukian and Krause), 1740-1751

Self-splicing, of group I introns (Michel et al.), 1373-1385

Sensory organ development, Drosophila

ac, sc, and emc proteins (Van Doren et al.), 2592-2605

Hairless (H), protein controls SOP cell fate (Bang and Posakony), 1752-1769

differentiation Drosophila transcription factor en-

coded by sd (Campbell et al.), 367-379

precursor (SOP) cells, Drosophila PNS H gene controls cell fate (Bang and Posakony), 1752-1769

Seplp, yeast, homology to Ratlp (Am- berg et al.), 1173-1189

Sevenless activity, different response of Drosophila ommatidial cells to (Dickson et al.), 2327-2339

Sexual development, Coprinus, A-mat- ing-type gene complexes (Kfies et al.), 568-577

r C. flagellum biosynthesis (Brun and Shapiro), 2395-2408

Signal transduction pathway

Drosophila, nuclear transport of dor- sal protein (Norris and Manley), 1654-1667

HTLV-1, Taxi aberrant induction of cell growth (Fujii et al.), 2066- 2076

intracellular, S. pombe, coupling of mitosis to completion of DNA replication (Enoch et al.), 2035- 2046

Ras mediates 4E-induced transfor- mation (Lazaris-Karatzas et al.), 1631-1642

Dictyostelium, G protein ot subunit (Hadwiger and Firtel), 38-49

Raf- 1 proto-oncogene activation (Bruder et al.), 545-556

S. cerevisiae pheromone response (Cairns et al.),

1305-1318 phosphorylation of FUS3 kinase

(Gartner et al.), 1280-1292 yeast pheromone response (Stevenson

et al.), 1293-1304 Single-stranded DNA-binding

activity, MF3 (Gualberto et al.), 815- 824

protein (SSB), E. coli, required for N4 early transcription (Markiewicz et al.), 2010-2019

Site-specific binding, of wild-type p53 protein (Bar-

gonetti et al.), 1886-1898 cross-linking, of mammalian U5 sn-

RNP to 5' splice site (Wyatt et al.), 2542-2553

snail gene expression, Drosophila meso- derm, dorsal-twist interaction (Ip et al.), 1518--1530

SNF proteins, S. cerevisiae, and tran- scriptional activation (Laurent and Carlson), 1707-1715

snRNA, U3, nuclear import of (Baserga et al.), 1120-1130

Somatic inhibition, Drosophila P-ele- ment pre-mRNA splicing (Sie- bel et al.), 1386-1401

GENES & DEVELOPMENT 2683

Spindle pole body, S. cerevisiae, genes involved in (Page and Snyder), 1414-1429

spitz Drosophila gene, encodes putative EGF-like growth factor (Rut- ledge et al.), 1503-1507

Splice site selection, 5' splice site com- petition model (Siebel et al.), 1386-1401

Spliceosome formation, and heat shock interference

{Utans et al.), 631-641 protein components of (Bennet et al.),

1986-2000 U6 snRNA association with 5'-splice

site of pre-mRNA (Sawa and Shimura), 244-254

Splicing defects, cytoplasmic tail, resulting ab-

normalities (Brannan et al.), 1832-1842

factors human ASF/SF2, Drosophila RNA-

binding protein RBP1 shows functional similarity to (Kim et al.), 2569-2578

SLU7, 3' splice site choice in yeast (Frank and Guthrie), 2112-2124

SR proteins, conserved family (Zahler et al.), 837-847

inhibition, by nonsense mutations (Naeger et al.), 1107-1119

mechanism, spliceosome and prespli- ceosome, protein components associated with (Bennet et al.), 1986-2000

mitochondrial group I introns {Guo and Lambowitz), 1357-1372

Spore viability, Dictyoste//um, and dis- ruption of spiA gene (Richarson and Loomis), 1058-1070

Sporulation Dictyoste//um, and disruption of spiA

gene (Richarson and Loomis), 1058-1070

pathways, N. crassa, con gene expres- sion {Springer and Yanofsky), 1052-1057

SPT3, S. cerevisiae, interaction with TFIID {Eisenmann et al.), 1319- 1331

SR proteins, pre-mRNA splicing factors, conserved family (Zahler et al.), 837-847

SSL1 supressor gene, yeast, role in DNA repair and/or translation initia- tion {Yoon et al.), 2463-2477

Stalk formation, Caulobacter, role of 0 "54

factor (Brun and Shapiro), 2395- 2408

Starvation, E. co//, DNA-binding protein Dps (Almir6n et al.), 2646-2654

Stationary phase of E. coli, role of DNA- binding protein Dps (Almir6n et al.), 2646-2654

STE7 kinase, dominant STE11 allele po-

tentiates phosphorylation (Cairns et al.), 1305-1318

STEI1 kinase, dominant allele potenti- ates phosphorylation of STE7 [Cairns et al.), 1305-1318

STE11. See also kinases Steel factor (SLF1 cytoplasmic tail, splic-

ing defect and developmental abnormalities {Brannan et al.), 1832-1842

STEII kinase, S. cerevisiae, constitutive mutants of IStevenson et al./, 1293-1304

Stem-loop structure, stabilizing influ- ence in E. coli mRNA (Emory et al.), 135-148

Stunted (stuA) gene, A. nidulans, re- quired for cell pattern formation (Miller et al.), 1770-1782

Subtractive hybridization, of cDNA li- braries (Rothstein et al.), 1190- 1201

sunY intron, bacteriophage T4 (Michel et al.), 1373-1385

Supercoiling (negativel, yeast rRNA transcription initiation (Schultz et al.), 1332-1341

Supercoiling. See also template super- coiling

SV40 T antigen, inhibits wild-type p53 binding (Bargonetti et al.), 1886-1898

SWI4 RNA accumulation, S. cerevisiae late G~, SIT4 protein phos- phatase required for {Fernandez- Sarabia et al.), 2417-2428

SW15, yeast transcriptional activator {Dohrmann et al.), 93-104

T

T/E1A-binding domain, the RB 'pocket' (Qin et al.), 953-964

Tat HIV- 1 in vitro processivity factor (Kato et al.),

655-666 protein, activation domain inter-

changeable with VP16 (Tiley et al.), 2077-2087

TATA box -binding

polypeptide {TBP), part of holo- TFIID complex (Zhou et al.I, 1964-1974

protein complex, TBF-TAT complex hSL1 (Jantzen et al.), 1950-1963

chick 13-globin gene, interaction with cGATA-1 (Fong et al.), 521-532

protected from KMnO 4 by TBP com- ponent of TFIID (Giardina et al.), 2190-2200

TFIID binding to {Lorch et al.), 2282- 2287

TATA-less promoter, holo-TFIID sup- ports transcriptional stimula- tion from (Zhou et al.), 1964- 1974

Tax 1 transcriptional activator and trans- forming protein, HTLV-1, inter- action with p67 sv'v causes aber- rant induction of cell growth {Fujii et al.I, 2066-2076

TEF-1, homology to TEA domain of Drosophila sd (Campbell et al.), 367-379

Telomere -binding protein, MF3 [Gualberto et

al.), 815-824 formation, P. primaure//a genome re-

organization (Meyer), 211-222 structure, RAP1 regulation of (Hardy

et al.}, 801-814 Telomeres, S. cerevisiae, assume non-

nucleosomal chromatin struc- ture {Wright et al.), 187-210

Telosome, yeast chromosomal DNA, as- sembled in non-nucleosomal chromatin structure {Wright et al.), 187-210

Template supercoiling, role in N4 early promoter activation {Mark- iewicz et al.), 2010--2019

Tenascin extracellular matrix protein, normal development of TN-de- ficient mice (Saga et al.), 1821- 1831

Termination/attenuation, block to tran- scriptional elongation in c-myc gene (Krumm et al.), 2201-2213

TFIIA and IID, assembly of closed com- plex (Wang et al.), 1716-1727

TFIIB-related factor, BRF 1, involvement in RNA Pol III transcription (Colbert and Hahn), 1940-1949

TFIID binding, to nucleosome, failure to sup-

port vs support of transcription initiation (Lorch et al.), 2282- 2287

holo--TFIID, supports activation by di- verse activators and TATA-less promoter (Zhou et al.), 1964- 1974

interaction with TATA-containing and TATA-lacking promoters (Colgan and Marfley), 304-315

S. cerevisiae, SPT3 interaction {Eisen- mann et al.), 1319-1331

yeast and human, fianctional equiva- lent of (Kelleher III et al.), 296- 303

TFIIF, transcription elongation factor, in conjunction with Tat (Kato et al.), 655-666

3' splice site selection, yeast, mediated by splicing factor SLU7 (Frank and Guthrie), 2112-2124

3T3-L 1 preadipocyte differentiation, role of antisense C/EBP RNA (Lin and Lanel, 533-544

Tissue specific diversity, maize B gene and anthocya-

2684 GENES & DEVELOPMENT

nm production (Radicella et al.), 2152-2164

expression, Adh, conserved regulatory unit in Drosophila and man (Falb and Maniatis), 454--465

mechanism, conservation between Drosophila and man (Abel et al.), 466-480

Tobacco, transgenic plant system, struc- ture/function relationship of phyA (Stockhaus et al.), 2364- 2372

Toll gene, Drosophila, role in regulating cell localization (Norris and Manley), 1654-1667

Topoisomerases yeast, inactivation of and transcription by RNA poly- merase I (Schultz et al.), 1332- 1341

Tracking, V(D)J recombination {Gauss and Lieber/, 1553--1561

Transcript cleavage, and elongation fac- tor SII (Izban and Luse), 1342- 1356

Trans-activation domain, in FosB but not FosB2 (Wis-

dom et al.), 667-675 ets family members have different

properties (Wasylyk et al.}, 965- 974

HW-1 Tat, mechanism of (Kato et al.), 655-666

Trans-activator papillomavirus E2 protein (Prakash et

al.), 105-116 Vpl6 and Tat, interchangeable activa-

tion domains (Tiley et al.I, 2077-2087

Transcription activation

adenovirus Ela protein represses HLH protein Myf-5 (Braun et al.), 888-902

domains, of hUBF (Jantzen et al.), 1950-1963

encoded by maize B gene (Goff et al.), 864-875

HOB motifs of Fos and lun (Suther- land et al.), 1810-1819

holo-TFIID complex and diverse ac- tivator domain interaction (Zhou et al.), 1964-1974

of N4 early promoter by supercoil- ing and SSB (Markiewicz et al.), 2010-2019

by NF-KB subunits (Fujita et al.), 775-787

repression of by Fos and Jun (Li et al.), 676-689

S. cerevisiae, SNF proteins function coordinately with GAL4 and Bi- cold (Laurent and Carlson), 1707-1715

Saccharomyces G~-specific genes, cdc28 kinase and passage

through START (Marini and Reed), 557-567

yeast and human TFIIDs, functional equivalent of (Kelleher III et al.}, 296-303

activators GAL4 and Bicoid, dependence on

SNF proteins (Laurent and Carl- son), 1707-1715

SNF and SWI yeast proteins alter chromatin structure (Hir- schhom et al.), 2288-2298

antirepression, by GAL4-VP 16 {Croston et al.), 2270-2281

enhancers, models of mechanism of action (Geyer and Corces), 1865-1873

elongation, blocking of in human c-myc gene (Krumm et al.), 2201-2213

factor complex, NF-KB in (Ruben et al.),

730-744 Drosophila, CREB/ATF family (Abel

et al.), 466-480 evolutionary conservation, encoded

by Drosophila sd gene (Camp- bell et al.), 367-379

IIB {dTFIIB), Drosophila, analysis of (Wampler and Kadonaga), 1542- 1552

factor NF-KB, NLS/IKB interaction (Beg et al.), 1899-19t3

paired domain, BSAP (Adams et al.), 1589-1607

RARa, role in hematopoietic differ- entiation {Tsai et al.l, 2258- 2269

see also E2F transcription factor factors

C/EBP and LAP, dominant-negative inhibitor of transcription (Ron and Habener), 439--453

C/EBP mechanism of action (Milos and Zaret), 991-1004

junB and c-jun, functional role in fi- brosarcoma development (Bos- sy-Wetzel et al.), 2340-2351

muscle-specific {Yu et al.}, 1783- 1798

stage-specific, globin gene (Foley and Engel), 730-744

initiation, closed complex requiring acidic activator GAL4-AH, and TFIIA and IID (Wang et al.), 1716-1727

regulation Adh gene, conserved regulatory unit

in Drosophila and man (Falb and Maniatis), 454--465

and composite response elements (Miner and Yamamoto), 2491- 2501

Drosophila, differential regulation by homeo domain proteins UBX

and EVE {Johnson and Kras- now), 2177-2189

Drosophila, TFIID--promoter inter- action (Colgan and Manley), 304-315

SWl5/HO and ACE2/CTS1, parallel pathways (Dohrmann et al.), 93-104

repression, Drosophila, by su(Hw) (Geyer and Corces), 1865-1873

silencing, RAP1-RIF1 involvement {Hardy et al.), 801-814

termination E. coli S 10 operon, r-protein L4 and

transcription factor NusA have separable roles (Zengel and Lin- dahl), 2655-2662

factor-dependent (Roberts et al.), 1562-1574

negative regulation (Dubendorff et al.), 2524-2535

phosphorylation of RNAP II CTD hep- tapeptide repeats (Peterson et al.), 426-438

yeast rRNA, negative supercoiling and

topoisomerases (Schultz et al.), 1332-1341

TFIID/SPT3 interaction (Eisenmann et al.), 1319-1331

Transformation biphasic effect of Max protein on Myc

cotransformation (Prendergast et al.), 2429-2439

as distinct from immortalization (Ul- rich et al.), 876-887

by FosB but not FosB2 {Wisdom et al.), 667-675

pathway, Myc/Max compleses (Mukherjee et al.), 1480-1492

Transforming protein Tax 1, HTLV- 1, in- teraction with p67 s ~ (Fujii et al.), 2066-2076

Transgenic mice activated int-3 locus {Jhappen et al.),

345-355 c-myc-bearing (Benvenisty et al.),

2513--2523 effects of TNFa {Cheng et al.), 1444-

1456 entire 70-kb human [3-globin locus in-

troduced in (Stouboulis et al.), 1857-1864

prion replication iHecker et al.), 1213- 1228

Transgenic zebrafish, HOX promoter ac- tivation (Westerfield et al.), 591-598

Translation initiation, yeast, role of SSL1 gene product (Yoon et al.), 2463-2477

Translational activation, of c-myc 1 {Hannet al.),

1229-1240 control

of Drosophila hunchback gene, by

GENES & DEVELOPMENT 2685

cooperation of Pumilio and Nanos activity (Barker et al.), 2312-2326

of maternal mRNAs (Sall6s et al.), 1202-1212

X. laevis, activation of masked mRNAs by cytoplasmic poly(A) elongation (Simon et al.), 2580- 2591

coupling, bacteriophage P1 and P7, c4 RNA controlled expression of ant gene (Biere et al.}, 2409- 2416

frameshifting, E. coli dnaX gene (Tsuchihashi and Brown), 511- 519

initiation, internal ribosome binding (OH et al.), 1643-1653

tRNA genes, yeast, targets for Ty3 inte- gration (Chalker and Sand- meyer), 117-128

tRNA, relationship to Group I introns (Guo and Lambowitz), 1357- 1372

Tumor necrosis factor a (TNFa), effects of in transgenic mice (Cheng et al.), 1444-1456

Tumor progression factors, junB and c-jun (Bossy-Wetzel et al.}, 2340-2351

Ty3, integration, RNA polymerase III transcription initiation region (Chalker and Sandmeyer), 117- 128

Tyrosine metabolism, lethal albino mice (Ruppert et al.), 1430-1443

Tyrosyl-tRNA synthetase, binds the in- tron core (Guo and Lambowitz), 1357-1372

U

U1 snRNA, X. laevis genes, transcrip- tional activation at MBT (Lund and Dahlberg}, 1097-1106

U1 snRNP binding to pseudo and accurate 5'

splice site (Siebel et al.), 1386- 1401

targets splicing factor U2AF65 to 3' splice site (Hoffman and Grabowski), 2554-2568

U2AF65 3' splicing factor, interaction with U1 snRNP (Hoffman and Grabowski), 2554-2568

U3 snRNA, nuclear import, molecular signals for (Baserga et al.), 1120- 1130

U4/U6/U5 triple snRNP complex, entry into spliceosome (Utans et al.), 631-641

U5 snRNP (mammalian,), site-specific cross-linking to 5' splice site (Wyatt et al.), 2542-2553

U5 yeast snRNA, SLU4 and SLU7 genes

interact with (Frank and Guth- rie), 2112-2124

U6 snRNA, as catalytic element in spli- ceosome (Sawa and Shimura), 244--254

Ultrabithorax (Ubx) Drosophila, homeo domain protein

UBX (Johnson and Krasnow), 2177-2189

promoter activation, by nonessential zeste gene (Laney and Biggin), 1531-1541

UV cross-linking, U6 snRNA associated

with 5'-splice site of pre-mRNA {Sawa and Shimura), 244-254

resistance, yeast, affected by SSL1 gene (Yoon et al.), 2463-2477

V

V(D)J recombination, deletional vs. in- versional (Gauss and Lieber), 1553-1561

v-Ras, down-regulates nuclear PICA {Gallo et al.), 1621-1630

Vaccinia virus, poly(A) tail length (Ger- shon and Moss), 1575-1586

Vector, gene trap pGT4,5 in mouse ES cells (Skames et al.), 903-918

Vectors, promoter trap, gene disruption in ES cells (yon Melchner et al.), 919-927

Virion production, in vitro using raft cul- tures (Dollard et al.), 1131-1142

Viviparous-1 gene, maize seed matura- tion, activation of the C1 gene (Hattori et al.), 609-618

VP16 activates transcription from RNA tar-

get (Tiley et al.), 2077-2087 -induced positive control, transferred

from Oct-1 to Oct-2 by amino acid exchange (Lai et al.), 2058- 2065

protein, and Oct-1 multiprotein com- plex (C1), protein-protein inter- actions (Pomerantz et al.), 2047-2057

W

Wing development, Drosophila ap LIM gene Cohen et al.), 715-729

X

Xenopus laevis blastopore lip-specific gene, fork head

domain (Dirksen et al.), 599-608

development, poly(A) elongation and translational activation (Simon et al.), 2580-2591

LIM domain, homeo box gene XIim-1 (Taira et al.), 356-366

midblastula transition (MBT), tran- scriptional activation (Lund and Dahlberg), 1097-1106

Xenopus oocytes, nuclear imprint of U3 snRNA {Baserga et al.), 1120- 1130

Xlim-I homeo box gene, X. laevis LIM domain (Taira et al.), 356-366

Y

Yeast deadenylation, 3'-UTR dependent

(Lowell et al.), 2088-2099 GCN4, as probe for oncogenesis by

AP-I transcription factor (Oliv- iero et al.), 1799-1809

HAP1 activator, cofactor interaction (Turcotte and Guarente), 2001- 2009

MFA2 gene, deadenylation of tran- scripts {Muhlard and Parker), 2100-2111

parallel pathways of gene regulation (Dohrmann et al.), 93-104

pheromone response pathway, compo- nents order of action (Cairns et al.), 1305-1318

rRNA transcription, negative super- coiling and topoisomerase ac- tivity (Schultz et al.), 1332- 1341

see also Saccharomyces cerevisiae TFIIB-related factor BRF1, RNA Pol III

transcription (Colbert and Hahn), 1940-1949

TFIID, functional equivalent of (Kelle- her III et al.), 296-303

transcription activators, SNF2/SWI2 and SNF5 alter chromatin struc- ture (Hirschhorn et al.), 2288- 2298

Ty3 targets Pol III-transcribed genes (Chalker and Sandmeyer), 117- 128

YG023 gene, yeast, repeated motifs sim- ilar to Drosophila Pumilio (Barker et al.), 2312-2326

Z

zeste Drosophila gene, and activation of Ubx promoter (Laney and Big- gin), 1531-1541

Zinc finger protein

encoded by Drosophila qpp gene, oocyte nucleus localization (S6galat et al.), 1019-1029

Drosophila su(Hw), transcriptional repression (Geyer and Corces), 1865-1873

region, yeast regulators SW15 and ACE2 (Dohrmann et al.), 93-104

2686 GENES & DEVELOPMENT

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equationally in meiosis? by Giora Simchen and Yasser Hugerat Cyclin synthesis: Who needs it? byJeremy Minshull Steel factor and c-Kit receptor: From mutants to a growth factor

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