reverse gyrase—a topoisomerase which introduces positive superhelical turns into dna

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Page 1: Reverse gyrase—a topoisomerase which introduces positive superhelical turns into DNA

© Nature Publishing Group1984

Page 2: Reverse gyrase—a topoisomerase which introduces positive superhelical turns into DNA

© Nature Publishing Group1984

Page 3: Reverse gyrase—a topoisomerase which introduces positive superhelical turns into DNA

© Nature Publishing Group1984

Page 4: Reverse gyrase—a topoisomerase which introduces positive superhelical turns into DNA

© Nature Publishing Group1984

Page 5: Reverse gyrase—a topoisomerase which introduces positive superhelical turns into DNA

© Nature Publishing Group1984

Initiation of Replication *Strands must separate DnaA Helicases (DnaB and DnaC) SSBPs (Single Stranded Binding Proteins) DNA gyrase (topoisomerase)

Role of DNA gyrase and topoisomerase IV mutations in

Topoisomerase IV, not gyrase, decatenates products of site ...genesdev.cshlp.org/content/11/19/2580.full.pdf · Topoisomerase IV, not gyrase, decatenates products of site-specific

Site-specific interaction of DNA gyrase with DNA

Mycobacterium tuberculosisDNA gyrase ATPase domain … · 2017. 9. 23. · DNA gyrase, a type II topoisomerase, regulates DNA topology by creating a double-stranded break in one DNA

UNIVERZA V LJUBLJANI FAKULTETA ZA FARMACIJO · decatenation. DNA gyrase is a heterodimeric enzyme consisting of two DNA gyrase A subunits and two DNA gyrase B subunits, whereby the

N-Benzyl-3-sulfonamidopyrrolidinesAreaNewClassofBacterialDNA Gyrase … · 2011. 4. 14. · DNA gyrase inhibitor NXL101 binds E. coli and S. aureus DNA gyrase in vitro and also does

Topoisomerase I-Mediated Integration of Hepadnavirus

An Antitumor Drug-Induced Topoisomerase Cleavage Complex

Glutamate racemase from Mycobacterium tuberculosis inhibits DNA gyrase …repository.ias.ac.in/26723/1/310.pdf · 2016. 5. 17. · The inhibition of DNA gyrase requires the presence

Topoisomerase inhibtion by thaspine

Micrococcus luteus DNA gyrase: Active components and a model

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Crystal Structure of Human Topoisomerase 1

Topoisomerase I Inhibitors: Molecular and Cellular

Crystal structure and stability of gyrase fluoroquinolone ... · Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes from Mycobacterium tuberculosis Tim

Antibacterial Drugs in Fish Farms: Application and Its Effects · (enrofloxacin and ciprofloxacin) Bactericidal. Inhibition of DNA gyrase and topoisomerase Tar g et point mutations

Transcriptional Consequences of Topoisomerase Inhibition

Topoisomerase IV is a target of quinolones Escherichia · quinolones. Chief amongthese is the multistep resistance to quinolonesthatoccursclinically, inwhichmutationsin gyrase are

Topoisomerase II is required for the production of long ...digital.csic.es/bitstream/10261/88106/1/Topoisomerase II.pdf · Topoisomerase II is required for the production of long

UNDERGRADUATE STUDENT RESEARCH TALKS ... bacteria are resistant to a commonly prescribed class of antibiotics called fluoroquinolones (FQs). FQs inhibit bacterial DNA gyrase and topoisomerase

Superhelical PM2 DNA can be photochemically modified by u.v.

of superhelical DNA and single-stranded fragments

Original Article Benzaldehyde levofloxacin schiff ... · DNA gyrase subunit B (GyrB) have the same homology. Topoisomerase II central domain (amino acids 671-1200) and DNA gyrase

Gyrase inhibition

Repair of Topoisomerase I-Mediated DNA Damagediscover.nci.nih.gov/pommier/RepairTopoisomerase/Text.Repair.of... · Repair of Topoisomerase I-Mediated DNA Damage Yves Pommier*, Juana

Mechanism of Quinolone Inhibition of DNA Gyrase

Yeast DNA Topoisomerase II Is Encoded by a Single-Copy, … · 2017. 1. 26. · The enzyme DNA gyrase is encoded by two genes, gyrA and gyrB, and the availability of mutants and specific

Genetic Analysis of the Gyrase A-Like Domain of DNA ... · Genetic Analysis of the Gyrase A-Like Domain of DNA Topoisomerase I1 of Saccharomyces cerm’siae Winston Thomas, Rachelle

Pharmacokinetic-Pharmacodynamic Evaluation of Gepotidacin ... · either from mutations that alter the drug target enzymes, most often DNA gyrase and topoisomerase IV, or via efﬂux

Regulation of DNA gyrase operon in Mycobacterium …

Single-molecule imaging of DNA gyrase activity in living

Structural Dynamics and Mechanochemical Coupling in DNA Gyrase · Structural Dynamics and Mechanochemical Coupling in DNA Gyrase Aakash Basu1, Angelica C. Parente2,3 and Zev Bryant3,4

Disruption topoisomerase-DNA cleavage complexby DNA helicase

Ciprofloxacin Mediated Cell Growth Inhibition, S/G -M Cell ...nes are inhibitors of prokaryotic DNA gyrase, a DNA topoi-somerase (11, 12). Topoisomerase enzymes are essential for DNA