results from industry efficacy trials · 12.04.2006 · source of data data presented in this...

Results from Industry Efficacy TrialsGary L. Cloud, Ph.D.Ag Research AssociatesSycamore, GA

Source of Data

Data presented in this presentation came from agricultural chemical companies having products possessing sect. 3 or 18 registrations for the use on soybean to control soybean rust. Therefore, data presented in this presentation was data submitted by each company to the EPA for registration.

Companies Providing DataBASF The Chemical CompanyDuPont Chemical CompanySipcam Agro USA Inc.Syngenta Crop ProtectionValent U.S.A. Corporation

BASF Data provided by Ted Bardinelli

% Severity of ASR

0

10

20

30

40

50

60

70

% Severity

Check

Headline + metconazole (0.32 +0.42 l/ha)Headline + metconazole (0.25 +0.33 l/ha)Headline SBR (0.43 l/ha)

21 DALAa

b b b

Appl Dates: 3/23/06 (R2), 4/12/06 (R4)Nozzles – XR8001VS, 2 bar pressure,150 l/ha volume

Sao Paulo, BrazilSoybean Var. CD 202

% Defoliation

0102030405060708090

% Defoliation

Check



28 DALAa

c cb

Appl Dates: 3/23/06 (R2), 4/12/06 (R4)

Yield (g/3.78m2)

0100200300400500600700800900

1000

Yield

Check



b

aa a

Appl Dates: 3/23/06 (R2), 4/12/06 (R4)

% Severity of ASR

0

5

10

15

20

25

30

35

% Severity

Check

Headline 6.1 oz/A + NIS


Headline + Caramba (4.5 + 7.7oz/A) + NISCaramba 9.6 oz/A + NIS

Headline SBR 5.9 oz/A + NIS

51 DALAa

d d d

Appl Dates: 7/18/05 (R1), 8/01/05 (R3)Nozzles – hollowcones, 62-65 PSI, 20 gpa

dd

Georgia, USASoybean Var. H7242RR

% Defoliation

0

10

20

30

40

50

60

70

80

% Defoliation

Check






61 DALAa

c c c

Appl Dates: 7/18/05 (R1), 8/01/05 (R3)

c c

Yield (bu/A)

0

10

20

30

40

50

60

70

Yield

Check






c

a ab ab

Appl Dates: 7/18/05 (R1), 8/01/05 (R3)

ab ab

% Severity of ASR

0102030405060708090

100

% Severity

Check

Headline + Caramba (3.5 + 6.17oz/A)Caramba 9.6 oz/A

Headline SBR 7.8 oz/A

Folicur 3.6F 3.6 oz/A

11 DALAa

d d

b

c

Alabama, USASoybean Var. H7242RR

Appl Dates: 8/18/05 (R1), 9/09/05 (R3)Nozzle – XR8002, 30 PSI, 22 GPA

% Defoliation

0102030405060708090

% Defoliation

Check





25 DALAa

cb

b

Appl Dates: 8/18/05 (R1), 9/09/05 (R3)

c

Yield (bu/A)

0

5

10

15

20

25

30

35

40

Yield

Check





c

a a

b

Appl Dates: 8/18/05 (R1), 9/09/05 (R3)

b

ConclusionsHeadline + metconazole provided effective control of ASR in all three trials. The level of control from the Headline + metconazole treatment(s) was statistically comparable to the standard of Headline SBR.Caramba and Folicur did not provide equal control of ASR when compared to Headline + metconazole and Headline SBR.

Bayer CropScience

Efficacy Data to Support BCS Fungicides for the Management of Asian Soybean Rust

BCS Fungicides for Asian Soybean Rust (ASR) Control

Bayer CropScience has submitted four fungicides to EPA for Sec. 18 Quarantine Exemption registration

EPA Registration granted

EPA Registration granted

EPA Registration pending

EPA Registration pendingFolicur = tebuconazole (triazole) Stratego = Propiconazole + Trifloxystrobin (triazole/strobilurin)

Absolute = tebuconazole + trifloxystrobin (triazole/strobilurin) Proline = Prothioconazole (triazole)

Bayer CropScience Asian Soyubean Rust Trials in Brazil, 2005 Reg./Sec. 18 Fungicides (3 Trials, FA05GEB05D)

0102030405060708090

100

Unt.Fo

licur

3 oz

/aFo

licur

4 oz/a

Folic

ur +

Ind 3

oz/a

Folic

ur +

Ind 4

oz/a

Fol E

W 10

0g/h

Strateg

o 5.5 o

z/a

Strateg

o 7 oz

/a

Strateg

o 10 oz

/aLa

redo 7

oz/aDom

ark 5

oz/a

Domark

6 oz

/aHea

dline

6 oz/a

Headli

ne 9

oz/a

Quadris

6.1 o

z/a

Quadris

9.2 o

z/a

02468101214161820

Ave ASR RF01 RP01 LM01 Ave.CI </= 2.5% ASR severity at first fungicide application2-4 applications on a 14-24 day spray program

% C

rop

Resp

onse

ASR

Cont

rol,

% A

bbot

t

Folicur (4 fl oz/a) and Stratego (10 fl oz/a) offer safe, effective control of ASR (Asian soybean rust) as a preventative to early post infection (early curative) spray application. Addition of induce adjuvant with Folicur increased disease control but caused a slight increase in visual crop response.

Activity/selectivity of Folicur and Stratego was greater than or equal to all other competitive fungicides registered for control of ASR.

= Core use rates of BCS fungicides

Bayer CropScience Asian Soybean Rust Trials in Brazil- 2006 Reg./Sec.18 Fungicides (3 Trials, FD06NARBLD)

0

7783 83 78

70

85 88 89 87

64 64 68 74

89 8475 78 74

0102030405060708090

100

Untreate

d*

Folicur (

3 oz/a

)

Folicur 4

oz/a)

Fol. (3 oz

/a)+In

d.

Fol. (3 oz

/a)+B

ond

Strateg

o (10 o

z/a)+I

nd.

Absolut

e (5 o

z/a)

Absolut

e (6 o

z/a)

Absol. (

5 oz/a)

+Ind.

Absol. (

5 oz/a)

+Bond

Domark (5

oz/a)

Alto (4

oz/a)

Caramba (

8.2 oz/a

)

Top Guard

(7 oz

/a)

Headlin

eSBR (7

.8 oz/a

)

Car.+Hea

d. (9.64

oz/a)

Quilt (

14 oz/a

)+COC

Quilt (

20 oz/a

)+COC

PrioriX

tra (4

oz/a)

% A

SR C

ontro

l, %

Abb

ott)

02468101214161820

Ave ASR Control (3 Trials) Ave CI (3 Trials)

Untreated Ave: 80.2% ASR Severity CI Eval: Highest recorded level during trial

# Applications: 3 appl. (1st app at 1 to 2.5% ASR sev.)Spray Interval: 15-22 daysASR Eval. Date: 7-14 days after last appl.

% C

rop

Resp

onse

Folicur (4 fl oz/a) and Absolute (5 fl oz/a) offer safe, effective control of ASR (Asian soybean rust) as an preventative/ early post infection (early curative) spray application. Stratego (10 oz/a) + Induce provided less ASR control than either Folicur orAbsolute since most trials were applied early curative. Stratego is registered only for preventative application.

Activity/selectivity of Folicur and Absolute is greater than or equal to all other competitive fungicides registered for controlof ASR.

= Core use rates of BCS fungicides

Performanace of Absolute, Stratego and Folicur for Asian Soybean Rust Control and Yields - Brazil 2004-06

(14 Trial Comparison)

69.2

82.3

74.7

50

60

70

80

90

Untreated Folicur 4 (oz/a) Stratego (10 oz/a) + Ind.

Absolute (5 oz/a)

PHA

KPA

Cont

rol,

% A

bbot

t

100

120

140

160

180

200

220

Ave. % PHAKPA Control Ave. % Yield Rel. to Unt.

% Y

ield

Rel

. to

Unt

.

Untreated averaged 82.3% Asian soybean rust severity at evaluation

Absolute improved ASR (Asian soybean rust) control and provided higher soybean yields as compared to Folicur and Stratego in 14 side-by-side comparison trials conducted in Brazil from 2004-2006. Applications were made both preventative and early curative.

Bayer CropScience Asian Soybean Rust Control with Proline in Brazil, 2006 (5 Trials, FD06NARBLT)

0

82 84 87

010

20304050

607080

90100

Untreated Folicur 4 oz/a) Proline (2.5 oz/a) Proline (3 oz/a)

% ASR Control (Ave.)% Crop Response (Ave.)

# Applications: 3 applicationsSpray Interval: 14-22 days

Proline 480SC (Prothioconazole) improved Asian soybean rust (ASR) control as compared to Folicur. Applications were made both preventative and early curative.

Proline use rates on the proposed label are 2.5 to 3.0 oz/a.

BCS Soybean Rust Fungicide Options: Summary

Bayer CropScience has four fungicide options for Asian soybean rust management/controlFolicur and Stratego have EPA approved Sec. 18 Quarantine Emergency registrationAbsolute and Proline are awaiting EPA Sec. 18 Quarantine Emergency registration approvalFolicur, Absolute and Proline provide preventative and early curative control of Asian soybean rustStratego offers preventative control of Asian soybean rust

DuPont

2006 National Soybean Rust SymposiumResults from independent trials & preventive / curative

studies against ASR with FlusilazoleSt. Louis, Missouri-USA

November 29-December 1, 2006

A.Marçon, Ph.D. & A. Selley, MSc.

prepared for Session Coord. B. Kemerait/Gary Cloud

Yield comparisons of flusilazole versus azoxystrobin in independent identicaltiming trials in the USA in 2005 under no/low disease pressures

6.4

4.6

-1

1

3

5

7

9

11

13

1 2 3 4 5 6 7 8 9 10 11 1212

trial

s

Flusilazole 3-4oz/AAzoxystrobin 6.2oz/A

Yiel

d ov

er u

nspr

ayed

(bu

/A)

Conclusion: Under 12 field trials conducted in the USA, flusilazole provided 6.4 bu/A over untreated plots and 1.8 bu/A over azoxystrobin under no/low disease pressure.

1. Beltsville-MD*; 2. Blomington-IL*; 3. Dekalb-IL*; 4. Beltsville-MD*; 5. Auburn-IL*; 6. Greenville-MS*; 7. Watson-AR*; 8. Hoopeston-IL*; 9. Charleston-OH; 10. Hoytville-OH; 11. Monmouth-IL; 12. Perry-IL.

* Flusilazole spray provided statistically higher yield from untreated

Yield comparisons of flusilazole versus tebuconazole in independent identicaltiming trials in the USA in 2005 under no/low disease pressures

5.16

4.10

-4

1

6

11

16

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27

27 tri

als

Flusilazole 3-4 oz/A

Tebuconazole 4oz/A

Yiel

d ov

er u

nspr

ayed

(bu

/A)

Conclusion: Under 27 field trials conducted in the USA, flusilazole provided 5.16 bu/A over untreated plots and 1.06 bu/A over tebuconazoleunder no/low disease pressure.

1. Manheim-PA; 2. Beltsville-MD*; 3. Bloomington-IL*; 4. Dekalb-IL*; 5. Beltsville-MD*; 6. Tallassee-AL; 7. Crawfordvile-IA; 8. Fargo-ND*; 9. Auburn-IL*; 10. Urbana-IL; 11. Watson-AR*; 12. Greenville-MS*; 13. Lexington-IL; 14. Columbia-MO; 15. Larinburg-MO; 16. Hoopeston-IL*; 17. Hoyville-OH; 18. Geneva-MO; 19. Warsaw-VA*; 20. Charleston-OH; 21. Georgetown-DE*; 22. Monmouth-IL; 23. Perry-IL; 24. Nashua-IA; 25. West Lafayette-IN*; 26. Jennings County-IN; 27. Haskell-OK

* Flusilazole spray provided statistically higher yield from untreated

Preventive and post-infection control of ASR with fungicidesuntreated Azoxystrobin 6.2oz Flusilazole 3oz

Five-wk old plants sprayed (3 oz of Punch®, a 400EC containing flusilazole and with 6.2 oz of Quadris

®, a 250 SC containing

azoxsytobin), at 4 and 7 days before inoculation or 2 and 6 days after inoculation. Plants inoculated with 5 x 104 uredospores/ ml and were placed in a high humidity chamber for 24 h, then transferred to GC (24° C, 12 h photoperiod) for 7 d before visual evaluation

Conclusion: flusilazole demonstrated excellent preventive and post-infection control of ASR. With post-infection applications, however, only flusilazole controlled ASR while azoxystrobin was inactive.

Fungicides sprayed 2 days after inoculation

Fungicides sprayed 6 days after inoculation

Fungicides sprayed 4 days before inoculation

Preventive spray

Fungicides sprayed 7 days before inoculation

Post-infection spray

SipcamData provided by Dr. John French

Materials and MethodsPlanting Date – 12/9/05Timing of Fungicides –

V5R3

Rating System – 1-3 to denote position on plant (low, mid, upper) and 1-4 to denote severityRatings were taken every 5 days from 50 to 110 DAP

Research conducted 2005-06 by Dr. Clive Levy, Commercial Farmers Union, Zimbabwe

Vertical Displacement of ASR From vertical displacement (VD) ratings – all fungicide treatments had significantly lower ASR than the UTC.

0

20

40

60

80

100

AUDPC

Check Echo 720 V5 fb R3 Echo720 V5 fb Muscle R3Echo 90DF V5 fb Muscle R3 Echo 720 V5 fb Folicur R3 Echo 90DF V5 fb Folicur R3Folicur V5 fb R3 Muscle V5 fb R3

A value of 65.0 represents no symptoms recordedMuscle is a trademark of Sipcam Agro USA, Inc.Folicur is a registered trademark of Bayer CropScience

Severity of ASR From severity ratings –only the two applications of Muscle or Folicur and Echo 720 (V5) fb Muscle (R3) had significantly lower AUDPC values than the UTC.

0

20

40

60

80

100

120

AUDPC

Check Echo 720 V5 fb R3 Echo720 V5 fb Muscle R3Echo 90DF V5 fb Muscle R3 Echo 720 V5 fb Folicur R3 Echo 90DF V5 fb Folicur R3Folicur V5 fb R3 Muscle V5 fb R3

* **

Yield (Metric Tons/ha)

2.93

3.13.23.33.43.53.63.73.83.9

MT/ha

CheckEcho 720 V5 fb R3Echo720 V5 fb Muscle R3Echo 90DF V5 fb Muscle R3Echo 720 V5 fb Folicur R3Echo 90DF V5 fb Folicur R3Folicur V5 fb R3Muscle V5 fb R3

dd

aba

cd

ab

bc bc

100-Seed Weight (g)

0

5

10

15

20

25

Seed Wt (g)

CheckEcho720 V5 fb R3Echo720 V5 fb Muscle R3Echo 90DF V5 fb Muscle R3Echo 720 V5 fb Folicur R3Echo 90DF V5 fb Folicur R3Folicur V5 fb R3Muscle V5 fb R3

c c

ab ab

cb

ab a

ConclusionsEcho 720 or Echo 90DF (V5) fb Muscle (R3) and Echo 90DF (V5) fb Folicur (R3) gave the highest yieldsThe highest seed weights were obtained from Echo 720 (V5) or Echo 90DF (V5) fb Muscle (R3), Echo 90DF (V5) fb Folicur (R3) or 2 applications of either Muscle or Folicur.

Syngenta Crop ProtectionFungicides for the control of

ASR

Provided by Phil Brune, David Black, and Allison Tally - SCP

Objectives of 2006 trials Brazil Trials

Test Section 18 rates vs Sec 3 ratesEvaluate with and without adjuvants

US TrialsEvaluate on ASR if occursEvaluate new products on other diseases (data not presented)

Rate Comparison Results/Brazil

0102030405060708090

100

ASR Severity

Untreated Quad X 4 oz

Quad X 6.8 oz Alto 4 oz

Alto 5.5 oz Quad 5.5 + Alto 4

F001 (Heavy ASR Pressure)

Mid Canopy at 20 DAT - 2

% S

ever

ity

Section 18 vs Section 3Alto 4 vs 5.5Quadris Xtra 4 vs 5.5

All treatments provided significant ASR control.There were no differences in efficacy between the two rates of either Quadris Xtra or Alto. The current recommendation of Quadris + Alto also was effective.


26 DAT -2

All fungicide treatments delayed premature soybean defoliation.The higher rates reduced defoliation slightly more than the lower rates.Quadris + Alto also decreased defoliation.

0

20

40

60

80

100

% defoliation





0

5

10

15

20

25

30

Bu / Acre




F001 (Heavy ASR Pressure)Soybean Yield

All fungicides improved soybean yield compared to the untreated.

Higher rates of azoxystrobin in Quad Xtra- 6.8oz and Quadris 5.5 oz improved yields over ccz alone.

Adjuvant Results/Brazil – F003

0

10

20

30

40

50

60

70

80

90

100

% severity bu/A

Untreated Max Control

Qlt COC fb Qlt COC 14 Qlt COC fb Qlt COC 20

QX fb QX 4 Q + Alto fb Alto 4

Q + Alto NIS fb Alto 4

ASR Severity 20 DATB Mid Canopy

% S

ever

ity

nsd

Max control = Quadris + Alto starting at R1 followed by Quadris on a 7 day intervalControl was comparable with or without NISAll treatments significantly different from check, but not each other.

nsd

Control was equivalent with or without NIS or COC.Defoliation for treatments = 5% vs 99% in untreated.There was no phyto even at 2X rate.

0

10

20

30

40

50

60

70

80

90

100

% severity bu/A

Untreated QX 6.8

QX 6.8 + COC QX 13.7

QX 13.7 + COC

% S

ever

ity

Adjuvant Results/Brazil – F004

Example of correlation

As demonstrated previously, good foliar disease control reduces defoliation thereby increasing yields.Even the ‘weaker’treatment protected some of the yield.

0

10

20

30

40

50

60

70

80

90

100

defoliation dis severity yield

Untreated weaker trt stronger trt

ConclusionsSCP portfolio with cyproconazole or (propiconazole) + azoxystrobin will provide outstanding efficacy against ASR and other foliar pathogensFor best control:

ASR – need a triazoleCOC/adjuvant improves control slightlyOther diseases – need azoxystrobin

ValentData provided by Dr. John Altom

Materials and MethodsSpray Systems Used

Nozzles – Twin Fan (TJ60 8001)PSI – 50 – 63GPA - 15

Fungicide Application DatesA – 8/9/06 (R2)B – 8/21/06 (R3)C – 9/1/06 (R5)

% Incidence of ASRTiming A (8/9/06) R2

From a % incidence and severity standpoint, all Domark applications, Folicur, Headline + Folicurand Laredo treatments provided the greatest level of control. The solo Headline applications and the V-10116 treatments resulted in statistically higher ASR ratings

0

20

40

60

80

% Incidence

Check Domark 4 oz + COCDomark 5 oz + COC Domark 6 oz + COCFolicur 4 oz + COC Headline 4.68 oz + Folicur 3.1 oz + COCLaredo 8 oz + COC Headline 7.68 oz + COCHeadline 9.2 oz + COC V-10116 2.5 oz + COC

64 DAT

Timing A

% Severity of ASRAll fungicide treatments were statistical comparable to one anotherAll fungicide treatments were statistically different from the UTC treatment

0

0.2

0.4

0.6

0.8

% Severity

Check Domark 4 oz + COCDomark 5 oz + COC Domark 6 oz + COCFolicur 4 oz + COC Headline 4.68 oz + Folicur 3.1 oz + COCLaredo 8 oz + COC Headline 7.68 oz + COCHeadline 9.2 oz + COC V-10116 2.5 oz + COC

64 DAT

Timing A

% Incidence of ASRTiming B (8/21/06) R3

In terms of % incidence and severity, all fungicide treatments provided statistically similar and very effective control of ASR. Quadris was the only treatment which resulted in statistically higher ASR levels in both incidence and severity.

0

10

20

30

40

50

60

70

80

% Incidence

Check

Domark 5 oz + COC

Folicur 4 oz + COC

Headline 4.68 oz +Folicur 3.1 oz + COCLaredo 8 oz + COC

Quadris 6.2 oz + COC

V-10116 2.5 oz + COC

52 DAT

Timing B

% Severity of ASRAll fungicide treatments were statistically comparable except Quadris + COC.Quadris + COC was statistical comparable to the UTC treatment

0

0.1

0.2

0.3

0.4

0.5

0.6

% Severity

Check

Domark 5 oz + COC

Folicur 4 oz + COC

Headline 4.68 oz +Folicur 3.1 oz + COCLaredo 8 oz + COC

Quadris 6.2 oz + COC

V-10116 2.5 oz + COC

52 DAT

Timing B

% Incidence of ASRTiming C (9/01/06) R5

All fungicide treatments provided statistically similar and very effective control of ASR when considering the incidence and severity ratings.

010203040506070

% Incidence

Check Domark 4 oz + COCDomark 5 oz + COC Folicur 4 oz + COCHeadline 4.68 oz + Folicur 3.1 oz + COC Laredo 8 oz + COCQuadris 6.2 oz + COC V-10116 2.5 oz + COC

41 DAT

Timing C

% Severity of ASRAll fungicide treatments were statistically comparable All fungicide treatments were statistically different from the UTC treatment.

0

0.2

0.4

0.6

0.8

% Severity

Check Domark 4 oz + COCDomark 5 oz + COC Folicur 4 oz + COCHeadline 4.68 oz + Folicur 3.1 oz + COC Laredo 8 oz + COCQuadris 6.2 oz + COC V-10116 2.5 oz + COC

41 DAT

Timing C

results from industry efficacy trials · 12.04.2006 · source of data data presented in this...

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