Results

13 papers

Heterogeneity of morphokinetic and conditions (culture media, mode of fertilization, day of ET)

Results

Only one study demonstrated significantly improved

clinical pregnancy rates when embryos were

selected by TLM in addition to conventional

morphology

Conclusion

While TLM has the potential to revolutionize clinical

embryology, there are currently no high-quality data

to support the clinical use of this technology for

selection of human preimplantation embryos.

Conclusions

reliable prediction of blastocyst conversion based on

early morphokinetic markers may be the main advantage

of TLM.

Surprisingly few data, however, indicate whether TLM

effectively distinguishes between embryos with high and

low implantation potential

Conclusions

Our intent in writing this review is not to discourage

further research regarding the clinical utility of TLM

for embryo selection, but rather, quite the opposite:

we hope to cast light on unresolved questions and

inconsistencies in current nomenclature in order to

motivate future appropriately designed studies

Time-lapse embryo imaging for improving reproductive outcomes: asystematic review and meta-analysis US Obstet Gynecol 2014

we only included RCTs comparing time-lapse

embryo imaging versus standard embryo monitoring

Results

2 RCT were included

A total of 138 women : 68 were allocated for time-

lapse monitoring system and 70 were allocated for

conventional incubation (EmbryoScope, Primo Vision time-

lapse system)

Results

Clinical pregnancy: The pooled estimate was not

sufficiently precise to identify whether TLM causes a

small benefit, no effect or small harm: RR 1.05, 95%

CI 0.80 to 1.38, P = 0.73

There is no evidence from RCTs about the effect of TLM on

live birth.

The current evidence from available RCTs shows that TLM

does not cause a large change on the chance of achieving

clinical and/or ongoing pregnancy when transferring blastocyst

stage embryos

Future directions

An ideal study- measure implantation rates among

patients randomized to SET following:

a) embryo culture in a TLM with selection based on

conventional morphology alone

b) embryo culture in a TLM with selection based on

morphokinetic parameters plus conventional morphology

the ESHRE stated that the aim of IVF treatments is

the birth of a single neonate, while a multiple

pregnancy is considered a complication of IVF

treatment

eSET (BLT)

Results Meir

10 mon. of embryoscope

161 cycles.

3 did not reach ET

74 SET, 39 eSET

45 DET

Results p-Value Double-

Embryo transfer(n=45)

Elective Single –embryo transfer(n=39)

0.006 33.6 5.7± 30.5 4.8± Age (years)

0.76 23.9± 3.74 23.5 ±5.6 Body mass index(Kg/m²)

0.37 0.8± 0.6 1.0 0.9± Gravidity

0.06 0.5± 0.6 0.8 0.8± Parity

0.06 2.8± 1.9 2.1± 1.6 Previous IVF cycles

0.65 2.7± 2.9 2.4 1.5± Duration of infertility (years)

0.7 7.0± 3.6 6.7± 2.9 Basal FSH (IU/ml)

Results p-Value Double-

Embryo transfer(n=45)

Elective Single –embryo transfer(n=39)

0.24 1683± 1157 1966 ± 1003 E2 level HCG (pg/ml)

0.61 0.6± 0.4 0.7± 0.5 Progesterone at HCG (ng/ml)

0.1 10.6± 4.4 12.3± 5.0 No. of oocytes retrieved

0.77 54.7± 20.4 53.6± 15.9 Fertilization rate)%(

0.62 3.0± 1.5 3.2± 1.7 Available embryos for ET

0.60 3.4± 0.6 3.3± 0.9 Embryo grading

p-Value

Double-Embryo transfer(n=45)

Elective Single –

embryo transfer(n=39)

0.8 46.6% 51.3% Chemical pregnancy

0.9 40.0% 43.6% Clinical pregnancy

0.05 27.8% 0% Multiple pregnancy

Results

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