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Page 1: Respiratory System 1. Main Function = gas exchange from O2  CO2 Main Function = gas exchange from O2  CO2 Other functions: speech (sounds) regulation

Respiratory SystemRespiratory System

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Respiratory SystemRespiratory System

Main Function = gas exchange from Main Function = gas exchange from O2 O2 CO2 CO2

Other functions: speech (sounds) Other functions: speech (sounds) regulation of pH of blood.regulation of pH of blood.

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Respiratory SystemRespiratory System 1. NOSE1. NOSE 2. NASAL CAVITY2. NASAL CAVITY 3. PHARYNX3. PHARYNX 4. LARYNX4. LARYNX 5. TRACHEA 5. TRACHEA 6. BRONCHI6. BRONCHI 7. BRONCHIOLES7. BRONCHIOLES 8. ALVEOLI8. ALVEOLI 9. Diaphragm9. Diaphragm

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Respiratory System

Figure 21.14

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NOSENOSE

This is there because of a number of This is there because of a number of hyaline cartilages. hyaline cartilages.

It’s fairly complex. It’s fairly complex.

A cartilage nasal septum divides the A cartilage nasal septum divides the right and left sides of the nose.right and left sides of the nose.

Nose jobs involve taking a mallet, Nose jobs involve taking a mallet, breaking the nasal bone and a breaking the nasal bone and a scalpel to shave the cartilages.scalpel to shave the cartilages.

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Like Pinocchio, your nose shows when you lie, http://fxn.ws/VtA93z

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Psychology researchers from the University of Granada in Spain used Psychology researchers from the University of Granada in Spain used thermography to study the temperature of people's faces in thermography to study the temperature of people's faces in experiments. They said they found a jump in the temperature around experiments. They said they found a jump in the temperature around the nose and in the orbital muscle in the inner corner of the eye during the nose and in the orbital muscle in the inner corner of the eye during lying. They also found that face temperature drops for people lying. They also found that face temperature drops for people performing a difficult mental task and rises for people experiencing performing a difficult mental task and rises for people experiencing high anxiety.high anxiety.

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NASAL CAVITYNASAL CAVITY

The outer skin folds into the anterior The outer skin folds into the anterior nostrils, where there are hairs which nostrils, where there are hairs which filter large particles (insects and dust). filter large particles (insects and dust). The nasal cavity is lined by The nasal cavity is lined by

NASAL MUCOSA NASAL MUCOSA (pseudostratisfied ciliated (pseudostratisfied ciliated epithelium). epithelium).

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Functions of the nasal cavity Functions of the nasal cavity are are

for the air you breathe:for the air you breathe:

Warm (cold air can freeze lungs); warmed Warm (cold air can freeze lungs); warmed by superficial veins.by superficial veins.

Clean (dirty air can clog lungs); mucous is Clean (dirty air can clog lungs); mucous is sticky, and cilia will move that dirt down sticky, and cilia will move that dirt down the back of the throat, then it’s swallowed.the back of the throat, then it’s swallowed.

Humidify (dry lungs can crack). The fluid Humidify (dry lungs can crack). The fluid secreted by glands makes the moisture, secreted by glands makes the moisture, even on windy days the air goes to 100% even on windy days the air goes to 100% humidity by the time it gets to the lungs.humidity by the time it gets to the lungs.

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Upper Respiratory Tract

Figure 21.3a11

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Superior, middle, and inferior Superior, middle, and inferior nasal conchaenasal conchae

Covered with a mucous membrane. Covered with a mucous membrane. Warm and moisten the airWarm and moisten the air Increase the turbulence in the flow of Increase the turbulence in the flow of

air through the nasal cavityair through the nasal cavity Sensory receptors to enhance the Sensory receptors to enhance the

sense of smell.sense of smell. When you have a cold and get extra When you have a cold and get extra

fluid (edema) fluid (edema) runny nose. runny nose. 1212

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Woman's running nose revealed to be leaking brain fluid, http://fxn.ws/Vr31JR

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Nasal ConchaeNasal Conchae The nasal conchae contain blood The nasal conchae contain blood

vessels that can dilate, causing the vessels that can dilate, causing the tissue to swell, closing off one side of tissue to swell, closing off one side of your nasal airway at a time. This your nasal airway at a time. This allows the closed side to increase its allows the closed side to increase its moisture.moisture.

Then it will open again and the other Then it will open again and the other side may close. These cycles occur side may close. These cycles occur every eight hours throughout the day.every eight hours throughout the day.

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What causes snoring?What causes snoring? When we are asleep the area at the back When we are asleep the area at the back

of the throat sometimes narrows. of the throat sometimes narrows. The same amount of air passing through The same amount of air passing through

this smaller opening can cause turbulence this smaller opening can cause turbulence in the airflow and some vibration of the in the airflow and some vibration of the tissues in the nose and mouth. tissues in the nose and mouth.

People who snore have different reasons People who snore have different reasons for the narrowing. The narrowing can be in for the narrowing. The narrowing can be in the nose, mouth, or throat. the nose, mouth, or throat.

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SnoringSnoring Obstruction of the nasal passages can be caused Obstruction of the nasal passages can be caused

by a deviation of the nasal septum, allergies, by a deviation of the nasal septum, allergies, sinus infections, swelling of the conchae, or sinus infections, swelling of the conchae, or large adenoids (tonsils in the back of the nose). large adenoids (tonsils in the back of the nose).

Those who have nasal obstructions cannot Those who have nasal obstructions cannot breathe through their noses well, so they breathe through their noses well, so they breathe through their mouths.breathe through their mouths.

Many mouth breathers snore because the flow Many mouth breathers snore because the flow of air through the mouth causes greater of air through the mouth causes greater vibration of tissues. vibration of tissues.

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SnoringSnoring When we lie on our backs, gravity pulls the When we lie on our backs, gravity pulls the

palate, tonsils, and tongue backwards. This often palate, tonsils, and tongue backwards. This often narrows the airway enough to cause turbulence narrows the airway enough to cause turbulence in airflow, tissue vibration, and snoring. in airflow, tissue vibration, and snoring.

Frequently, if the snorer is gently reminded to Frequently, if the snorer is gently reminded to roll onto his or her side, the tissues are no roll onto his or her side, the tissues are no longer pulled backwards and the snoring longer pulled backwards and the snoring lessens.lessens.

Some medications as well as alcohol can lead to Some medications as well as alcohol can lead to enhanced relaxation of muscles during sleep. enhanced relaxation of muscles during sleep. This will increase snoring.This will increase snoring.

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Deviated SeptumDeviated Septum

Nasal septa which are deviated to Nasal septa which are deviated to one side of the nasal passage can one side of the nasal passage can cause sinus problems and decreased cause sinus problems and decreased ability to smell and taste.ability to smell and taste.

A surgery can be performed to A surgery can be performed to correct it:correct it:

VIDEO http://www.youtube.com/watch?v=SP01dYof8RUhttp://www.youtube.com/watch?v=SP01dYof8RU

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SeptoplastySeptoplasty

Flexible splints Flexible splints are held in are held in place in the place in the nose with a nose with a stitch through stitch through the hole, and the hole, and are removed are removed 7-10 days 7-10 days after surgery.after surgery.

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ApneaApnea

An apnea is a period of time during which An apnea is a period of time during which breathing stops for 10+ seconds or the breathing stops for 10+ seconds or the breath is 25% less than normal. Apnea is breath is 25% less than normal. Apnea is also a term for blood oxygen levels 4% also a term for blood oxygen levels 4% less than normal.less than normal.

These episodes often occur during sleep.These episodes often occur during sleep. The two types of sleep apnea are Central The two types of sleep apnea are Central

Sleep Apnea and Obstructive Sleep Sleep Apnea and Obstructive Sleep Apnea.Apnea.

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Central Sleep Apnea (CSA)Central Sleep Apnea (CSA)

Occurs when the brain does not send Occurs when the brain does not send the signal to breathe to the muscles of the signal to breathe to the muscles of breathing. breathing.

This usually occurs in infants or in This usually occurs in infants or in adults with heart disease, adults with heart disease, cerebrovascular disease, or congenital cerebrovascular disease, or congenital diseases, but it also can be caused by diseases, but it also can be caused by some medications and high altitudes. some medications and high altitudes.

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Obstructive Sleep Apnea Obstructive Sleep Apnea (OSA)(OSA)

People with OSA have an airway that is People with OSA have an airway that is more narrow than normal, usually at the more narrow than normal, usually at the base of the tongue and palate. It is base of the tongue and palate. It is common among adults but rare among common among adults but rare among children. children.

OSA is associated with higher risks of OSA is associated with higher risks of heart attacks and strokes because of heart attacks and strokes because of higher prevalence of hypertension in higher prevalence of hypertension in individuals with obstructive sleep individuals with obstructive sleep apnea. apnea.

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PolypsPolyps

Nasal polyps are overgowths of the Nasal polyps are overgowths of the mucosal tissue in the nasal cavities.mucosal tissue in the nasal cavities.

Usually caused from chronic allergiesUsually caused from chronic allergies Can cause difficulty breathing through Can cause difficulty breathing through

nose, loss of smell, headaches.nose, loss of smell, headaches. Treated with steroid sprays or Treated with steroid sprays or

surgery.surgery.

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SinusesSinuses The nasal cavity is connected to The nasal cavity is connected to PARANASAL PARANASAL

SINUSES (ETHMOID, SPHENOID, FRONTAL, SINUSES (ETHMOID, SPHENOID, FRONTAL, AND MAXILLARY SINUSES).AND MAXILLARY SINUSES).

They are also lined with the same kind of They are also lined with the same kind of mucosa. mucosa.

When you have a cold, you get stuffed up, and When you have a cold, you get stuffed up, and the pressure can cause sinus headaches.the pressure can cause sinus headaches.

Some people with headaches and sinus pain Some people with headaches and sinus pain assume they have a sinus headache, but the assume they have a sinus headache, but the CT scan shows clear sinuses. They actually CT scan shows clear sinuses. They actually have a problem with cranial nerve V, causing have a problem with cranial nerve V, causing referred pain to the sinuses. They need to see referred pain to the sinuses. They need to see a neurologist.a neurologist.

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The Paranasal Sinuses

Figure 7.11a, b26

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LACRIMAL DUCTLACRIMAL DUCT

There is another connection to the There is another connection to the nasal cavity: nasal cavity: LACRIMAL DUCTLACRIMAL DUCT. .

There’s a hole in the lacrimal bone.There’s a hole in the lacrimal bone. Excess tears drip down there. Excess tears drip down there. When you cry, you get a runny nose. When you cry, you get a runny nose. If the duct overflows, you see tears If the duct overflows, you see tears

on face.on face.

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Fig. 23.2b(TE Art)

Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Oropharynx

Nasopharynx

Laryngopharynx

LARYNX28

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PharynxPharynx1. NASOPHARYNX1. NASOPHARYNX: a continuation of the nasal : a continuation of the nasal

cavity. cavity. The The EUSTACIAN TUBEEUSTACIAN TUBE is located here. is located here.

2. OROPHARYNX2. OROPHARYNX is the back of the mouth; is the back of the mouth; visible when you open your mouth and look all visible when you open your mouth and look all the way back.the way back.

Separating the oropharanyx and the Separating the oropharanyx and the nasopharynx:nasopharynx:

SOFT PALATE: SOFT PALATE: feel it with your tonguefeel it with your tongue UVULAUVULA: located at the end of the soft palate : located at the end of the soft palate The function of the soft palate and uvula is to The function of the soft palate and uvula is to

move upward when swallowing, to prevent food move upward when swallowing, to prevent food from going into nasal cavities. (They don’t close from going into nasal cavities. (They don’t close during vomiting)during vomiting)

3. LARYNGOPHARYNX3. LARYNGOPHARYNX: This is the area of the : This is the area of the PHARYNX that is closest to the LARYNX.PHARYNX that is closest to the LARYNX. 2929

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Pharynx

Figure 21.3a30

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Bifurcated Uvula

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LARYNXLARYNX

It has two functions:It has two functions: 1. Produce sounds (vocal cords)1. Produce sounds (vocal cords) 2. Prevent food from entering lungs2. Prevent food from entering lungs Made up of nine separate cartilages:Made up of nine separate cartilages: EPIGLOTTISEPIGLOTTIS THYROID CARTILAGETHYROID CARTILAGE CRICOID CARTILAGECRICOID CARTILAGE (2) (2) ARYTENOID CARTILAGESARYTENOID CARTILAGES (4) Tracheal cartilages(4) Tracheal cartilages

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Anatomy of the Larynx

Figure 21.5a, b33

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Glottis and EpiglottisGlottis and Epiglottis

GLOTTISGLOTTIS is the opening. It stays all the way is the opening. It stays all the way open when you are breathing hard.open when you are breathing hard.

EPIGLOTTIS EPIGLOTTIS flaps over the glottis when you flaps over the glottis when you swallow so nothing will go into the trachea. swallow so nothing will go into the trachea. When you get hiccoughs, it’s from a sudden When you get hiccoughs, it’s from a sudden movement of air into the lungs, so the movement of air into the lungs, so the epiglottis closes to prevent more air from epiglottis closes to prevent more air from going in. It’s unknown why you get hiccoughs. going in. It’s unknown why you get hiccoughs. All the treatments you can try involve All the treatments you can try involve interrupting the normal breathing patterns.interrupting the normal breathing patterns.

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Vocal Cords

Figure 21.636

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Vocal CordsVocal Cords VOCAL CORDS (vocal folds)VOCAL CORDS (vocal folds) Vocal cords are attached to the Vocal cords are attached to the

ARYTENOID CARTILAGESARYTENOID CARTILAGES. If these . If these cartilages move, the vocal cords open. cartilages move, the vocal cords open. When they go back to normal, the glottis When they go back to normal, the glottis will close. will close.

The ability to vary the pitch of the voice The ability to vary the pitch of the voice results from varying the tension in the results from varying the tension in the vocal folds. vocal folds.

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Vocal CordsVocal Cords

For air to move through, muscles have to For air to move through, muscles have to contract. If muscles here are paralyzed, the contract. If muscles here are paralyzed, the airway closes. In surgery, have to intubate. airway closes. In surgery, have to intubate. In an emergency airway obstruction, have to In an emergency airway obstruction, have to do a tracheotomy above the jugular notch. do a tracheotomy above the jugular notch.

The type of sounds you make depend on The type of sounds you make depend on how far apart the vocal cords are.how far apart the vocal cords are.

Way open = no sound (like when breathing)Way open = no sound (like when breathing) Mostly closed = soundsMostly closed = sounds Men: their thyroid cartilage is larger, so their Men: their thyroid cartilage is larger, so their

vocal cords are longer = deeper voice.vocal cords are longer = deeper voice.

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Problems with vocal cordsProblems with vocal cords LARYNGITISLARYNGITIS: inflamed vocal cords : inflamed vocal cords

((↓ sound production). Usually caused from ↓ sound production). Usually caused from overuse or a viral infection.overuse or a viral infection.

Extreme overuse (professional Extreme overuse (professional singers) can get singers) can get scar tissue scar tissue nodulesnodules, requires surgery., requires surgery.

Neurological speech evaluation VIDEO

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Mother hears her own voice again after nearly four

years, (text) http://fxn.ws/UElY8f

VIDEO: VIDEO: http://www.myfoxatlanta.com/story/1http://www.myfoxatlanta.com/story/19488651/mother-hears-her-own-9488651/mother-hears-her-own-voice-again-after-nearly-four-yearsvoice-again-after-nearly-four-years

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FUN FACTSFUN FACTS What is the Adam's apple and what does it do?What is the Adam's apple and what does it do? When boys go through puberty, hormones cause the When boys go through puberty, hormones cause the

larynx to grow rapidly, deepening their voices and larynx to grow rapidly, deepening their voices and causing the bulge to form. causing the bulge to form.

Enlargement of the Adam's apple is considered, like Enlargement of the Adam's apple is considered, like pubic hair growth, one of the secondary sexual pubic hair growth, one of the secondary sexual characteristics. characteristics.

Girls' voices also deepen with puberty, but since their Girls' voices also deepen with puberty, but since their larynxes don't tend to grow as much, they don't usually larynxes don't tend to grow as much, they don't usually develop an "Eve's apple." develop an "Eve's apple."

The protrusion is the thyroid cartilage. The protrusion is the thyroid cartilage. Some folks undergo cosmetic surgery to make it less Some folks undergo cosmetic surgery to make it less

prominent.prominent.

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FUN FACTSFUN FACTS

Origin of the term: Origin of the term: It is usually said that Adam's apple takes its name It is usually said that Adam's apple takes its name

from the biblical story about Adam, Eve. The from the biblical story about Adam, Eve. The serpent and the apple. A piece of the forbidden serpent and the apple. A piece of the forbidden fruit stuck in Adam's throat and created the fruit stuck in Adam's throat and created the anatomic Adam's apple. anatomic Adam's apple.

However, it may be wrong. Adam's apple in Latin However, it may be wrong. Adam's apple in Latin is "pomum Adami." This may have been a is "pomum Adami." This may have been a mistranslation of the Hebrew "tappuach ha adam" mistranslation of the Hebrew "tappuach ha adam" which also means male bump. Between Latin and which also means male bump. Between Latin and English there's many a slip. English there's many a slip.

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FUN FACTSFUN FACTS

Why does your voice sound funny after you Why does your voice sound funny after you inhale helium from a balloon?inhale helium from a balloon?

Helium is lighter than air, so it causes the tissues Helium is lighter than air, so it causes the tissues to vibrate faster, resulting in a higher-pitched, to vibrate faster, resulting in a higher-pitched, cartoon-character sound. cartoon-character sound.

A healthy 13-year-old boy suffered a cerebral gas A healthy 13-year-old boy suffered a cerebral gas embolism after inhaling helium from a embolism after inhaling helium from a pressurized tank at a party. pressurized tank at a party.

Repeated inhalation of helium can hinder your Repeated inhalation of helium can hinder your ability to breathe.ability to breathe.

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TRACHEATRACHEA

This is a tube that carries air from the This is a tube that carries air from the larynx to the lungs. larynx to the lungs.

It’s fairly rigid from about 16 rings of It’s fairly rigid from about 16 rings of cartilage.cartilage.

The purpose of the cartilage rings is to keep The purpose of the cartilage rings is to keep the trachea open. Otherwise, when you the trachea open. Otherwise, when you inhale, the trachea would collapse like inhale, the trachea would collapse like when you suck hard on a straw. That’s why when you suck hard on a straw. That’s why your vacuum cleaner has rings on the hose.your vacuum cleaner has rings on the hose.

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The Trachea

Figure 21.7a45

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Histology of the tracheaHistology of the trachea

MUCOSA (MUCOSA (Inner, most superficial layer)Inner, most superficial layer) EPITHELIUMEPITHELIUM (pseudostratisfied ciliated (pseudostratisfied ciliated

epithelium) and goblet cells. Function of goblet epithelium) and goblet cells. Function of goblet cells is to produce mucous to trap dirt. Cilia move cells is to produce mucous to trap dirt. Cilia move dirt to larynx dirt to larynx swallowed. swallowed.

LAMINA PROPRIALAMINA PROPRIA (loose connective tissue) with (loose connective tissue) with lots of elastic fibers to make the trachea flexible.lots of elastic fibers to make the trachea flexible.

SUBMUCOSASUBMUCOSA (Deep to the mucosa) This is the (Deep to the mucosa) This is the serous portion to humidify the air.serous portion to humidify the air.

ADVENTITIAADVENTITIA (Deepest layer) This is dense (Deepest layer) This is dense connective tissue with hyaline cartilage.connective tissue with hyaline cartilage.

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BRONCHIBRONCHI The trachea branches into the The trachea branches into the RIGHTRIGHT and and LEFT LEFT

BRONCHUSBRONCHUS (the primary bronchi). (the primary bronchi). These branch into the secondary bronchi, which These branch into the secondary bronchi, which

branch into the tertiary bronchi.branch into the tertiary bronchi. The layers become thinner, and the hyaline The layers become thinner, and the hyaline

cartilage no longer has nice rings; just bits.cartilage no longer has nice rings; just bits. The tertiary bronchi are microscopic. The distal The tertiary bronchi are microscopic. The distal

part of the tertiary bronchi are called terminal part of the tertiary bronchi are called terminal bronchioles. These have smooth muscle and no bronchioles. These have smooth muscle and no more bits of hyaline cartilage. Beyond them are more bits of hyaline cartilage. Beyond them are the respiratory bronchioles, which are where the the respiratory bronchioles, which are where the air sacs are.air sacs are.

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If you inadvertently inhale something, which If you inadvertently inhale something, which lung does it go into? Right lung.lung does it go into? Right lung.

Lung cancer occurs slightly more frequently in Lung cancer occurs slightly more frequently in the right lung than in the left lung (about 53% the right lung than in the left lung (about 53% vs. 47% of the time). The most logical vs. 47% of the time). The most logical explanation for this is that the right primary explanation for this is that the right primary bronchus is wider than the left one (and the bronchus is wider than the left one (and the right lung is larger than the left lung), so the right lung is larger than the left lung), so the right lung receives slightly more carcinogenic right lung receives slightly more carcinogenic cigarette smoke with each puff.cigarette smoke with each puff.

The left lung has a cardiac notch; this is where The left lung has a cardiac notch; this is where the heart sits.the heart sits.

The left lung has TWO lobes, but the right lung The left lung has TWO lobes, but the right lung has THREE lobes.has THREE lobes.

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Cardiac Notch

Figure 21.8a

Cardiac Notch

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Fig. 23.9b(TE Art)

Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Apex

Superior lobe

Middle lobe

Hilum

Inferior Lobe

Secondary bronchi

Pulmonary Ligament

Diaphragmatic surface

Pulmonary veins

Pulmonaryarteries

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BRONCHIOLESBRONCHIOLES

(simple columnar epithelium, no cilia, no mucosa) (simple columnar epithelium, no cilia, no mucosa) The terminal bronchioles still have a smooth muscle The terminal bronchioles still have a smooth muscle layer, which functions to direct the flow of air to layer, which functions to direct the flow of air to particular portions of the lungs.particular portions of the lungs.

Right now, only a small percentage of your lungs are Right now, only a small percentage of your lungs are needed, compared to if you are running.needed, compared to if you are running.

Since there are no cilia, any particle that gets down Since there are no cilia, any particle that gets down that far has to be eaten by macrophages or just stay that far has to be eaten by macrophages or just stay there.there.

In allergic conditions, bronchioles will constrict, In allergic conditions, bronchioles will constrict, blocking air flow to the lungsblocking air flow to the lungs = = ASTHMAASTHMA. . Asthma can also be caused by irritants in the Asthma can also be caused by irritants in the environment, especially by pollution in the city.environment, especially by pollution in the city.

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Respiratory BronchiolesRespiratory Bronchioles Distal to the terminal bronchioles, the Distal to the terminal bronchioles, the

branches of the respiratory tree are now branches of the respiratory tree are now called respiratory bronchioles.called respiratory bronchioles.

These end in alveoli (air sacs) These end in alveoli (air sacs)

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ALVEOLIALVEOLI

These are made of simple squamous These are made of simple squamous epithelium. epithelium.

This sac is like a balloon surrounded This sac is like a balloon surrounded by a capillary bed. by a capillary bed.

Within the alveoli are macrophages Within the alveoli are macrophages and surfactant secreting cells.and surfactant secreting cells.

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Structures of the Respiratory Zone

Figure 21.9a56

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Alveoli

Figure 21.10b57

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Alveoli

Figure 21.10c, d58

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Fig. 23.10b

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Healthy Alveoli

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Alveoli with cancer

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Respiration VIDEO 1Respiration VIDEO 2http://www.youtube.com/watch?v=HiT621PrrO0

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The Respiratory Tree The Respiratory Tree

As the conducting tubes of the respiratory As the conducting tubes of the respiratory tree become smaller, the following tree become smaller, the following changes occurchanges occur Cartilage rings are replaced by irregular Cartilage rings are replaced by irregular

plates of cartilageplates of cartilage Cartilage disappears in the bronchiolesCartilage disappears in the bronchioles The lining epithelium thinsThe lining epithelium thins Elastin remains in the walls Elastin remains in the walls

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FUN FACTSFUN FACTS

Exactly what happens when you get Exactly what happens when you get the wind knocked out of you?the wind knocked out of you?

When you get hit in the abdomen, this can When you get hit in the abdomen, this can cause a pressure difference that makes cause a pressure difference that makes your diaphragm spasm for a few seconds. your diaphragm spasm for a few seconds.

You can't catch your breath until the You can't catch your breath until the spasm stops.spasm stops.

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FUN FACTSFUN FACTS

MYTH: MYTH: Cover your head or catch a Cover your head or catch a cold: Although 90% of the heat lost cold: Although 90% of the heat lost from the body is lost from the head, from the body is lost from the head, covering your head will not prevent covering your head will not prevent this heat loss. this heat loss.

The heat is lost from the warm air The heat is lost from the warm air that you exhale.that you exhale.

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6666

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Partial Pressure of Oxygen Partial Pressure of Oxygen (pO2)(pO2)

The air we breath is a mixture of gasses: primarily nitrogen, The air we breath is a mixture of gasses: primarily nitrogen, oxygen, & carbon dioxide. So, the air you blow into a oxygen, & carbon dioxide. So, the air you blow into a balloon creates pressure that causes the balloon to expand.balloon creates pressure that causes the balloon to expand.

However, the total pressure generated by the air is due in However, the total pressure generated by the air is due in part to nitrogen, in part to oxygen, in part to carbon part to nitrogen, in part to oxygen, in part to carbon dioxide. dioxide.

That part of the total pressure generated by oxygen is the That part of the total pressure generated by oxygen is the 'partial pressure' of oxygen, while that generated by carbon 'partial pressure' of oxygen, while that generated by carbon dioxide is the 'partial pressure' of carbon dioxide. A gas's dioxide is the 'partial pressure' of carbon dioxide. A gas's partial pressure, therefore, is a measure of how much of partial pressure, therefore, is a measure of how much of that gas is present (e.g., in the blood or alveoli).that gas is present (e.g., in the blood or alveoli).

The pO2 of blood therefore refers to the amount of The pO2 of blood therefore refers to the amount of dissolved oxygen in the blood plasma.dissolved oxygen in the blood plasma.

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DIAPHRAGMDIAPHRAGM When the When the

diaphragm diaphragm muscle contracts, muscle contracts, the size of the the size of the thoracic cavity thoracic cavity increases.increases.

Pressure and Pressure and volume are volume are inversely related, inversely related, so air rushes into so air rushes into the lungs. the lungs.

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BreathingBreathing

When the lungs inflate, the thoracic When the lungs inflate, the thoracic cavity expands for two reasons:cavity expands for two reasons:

The diaphragm pulls down, increases The diaphragm pulls down, increases volumevolume

The rib cage expands, increases volume.The rib cage expands, increases volume. When the diaphragm contracts, the size When the diaphragm contracts, the size

of the thoracic cavity increases, the of the thoracic cavity increases, the pressure inside the thoracic cavity pressure inside the thoracic cavity drops, and air flows into the lungs.drops, and air flows into the lungs.

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InspirationInspiration

The diaphragm The diaphragm and the and the external external intercostals intercostals are the muscle are the muscle group that group that produces produces inspiration.inspiration.

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Changes in Thoracic Volume

Figure 21.15d74

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PleuraPleura

Lining the thoracic cavity is Lining the thoracic cavity is PARIETAL PARIETAL PLEURAPLEURA..

Lining the lungs is the Lining the lungs is the VISCERAL PLEURAVISCERAL PLEURA.. Both of these are made of 2 layers (simple Both of these are made of 2 layers (simple

squamous epi and loose fibrous ct), same squamous epi and loose fibrous ct), same as the pericardium. Between these pleura as the pericardium. Between these pleura is a tiny space: is a tiny space: PLEURA CAVITYPLEURA CAVITY..

The pleura lubricate the lungs so when the The pleura lubricate the lungs so when the lungs move, it is smooth. They also form lungs move, it is smooth. They also form an airtight seal to allow the lungs to inflate. an airtight seal to allow the lungs to inflate.

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Diagram of the Pleural Cavities

Figure 21.1176

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PNEUMOTHORAXPNEUMOTHORAX

If there is a hole in the pleura (injury If there is a hole in the pleura (injury from broken rib, knife), it’s like from broken rib, knife), it’s like opening the stopper; air flows in opening the stopper; air flows in through the hole, and the lungs don’t through the hole, and the lungs don’t inflate = inflate = PNEUMOTHORAXPNEUMOTHORAX (air in (air in thorax) thorax) COLLAPSED LUNGCOLLAPSED LUNG..

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PLEURISYPLEURISY

The rubbing together of inflamed The rubbing together of inflamed pleural membranes that produces a pleural membranes that produces a stabbing pain in the chest with every stabbing pain in the chest with every breath; it feels like a broken rib. breath; it feels like a broken rib.

Usually the inflammation is caused Usually the inflammation is caused from an infection.from an infection.

It is fairly common.It is fairly common.

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Choking on Foreign BodyChoking on Foreign Body

1. Encouraging the victim to cough2. Back slaps3. Abdominal thrusts (Heimlich Maneuver)Self treatment abdominal thrustsModified chest thrustsFinger sweepingDirect vision removalCricothyrotomy

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Cricothyrotomy

In cricothyrotomy, the incision or puncture is made through the cricothyroid membrane in between the thyroid cartilage and the cricoid cartilage.

81

Cricothyrotomy is easier and quicker to perform than tracheotomy, does not require manipulation of the cervical spine, and is associated with fewer complications

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Smoking CommercialsSmoking Commercials

More Doctors smoke 1More Doctors smoke 1 http://www.youtube.com/watch?v=cKMn-_aQoPkhttp://www.youtube.com/watch?v=cKMn-_aQoPk

More Doctors smoke 2More Doctors smoke 2 http://www.youtube.com/watch?v=GrpmgWuwKB8http://www.youtube.com/watch?v=GrpmgWuwKB8

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Lung DamageLung Damage

Smoking destroys cilia, and smoke of any kind Smoking destroys cilia, and smoke of any kind is toxic. Particles in the lungs can’t clear. is toxic. Particles in the lungs can’t clear.

Cigarettes contain tar, which is the same kind Cigarettes contain tar, which is the same kind of tar used to pave roads. of tar used to pave roads.

When there is a thin lining of tar on the alveoli, When there is a thin lining of tar on the alveoli, there is no oxygen exchange to the lungs there. there is no oxygen exchange to the lungs there. Large chunks of the lung become useless. Large chunks of the lung become useless.

Damage to the lungs shows up several ways.Damage to the lungs shows up several ways.

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CHRONIC OBSTRUCTIVE CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)PULMONARY DISEASE (COPD)

Number 5 killer in the USA.Number 5 killer in the USA. It is one of two conditions:It is one of two conditions: CHRONIC BRONCHITISCHRONIC BRONCHITIS: inflammation of the : inflammation of the

bronchi, produces mucous, the openings bronchi, produces mucous, the openings become smaller = obstructed.become smaller = obstructed.

EMPHYSEMAEMPHYSEMA: scarring of elastic tissue on the : scarring of elastic tissue on the bronchioles and alveoli, which collapse now bronchioles and alveoli, which collapse now during exhalation. during exhalation. Characterized by a person with a large, “barrel” Characterized by a person with a large, “barrel”

chest.chest.

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Barrel Chest of EmphysemaBarrel Chest of Emphysema

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Barrel Chest of EmphysemaBarrel Chest of Emphysema

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EmphysemaEmphysema A person with emphysema is like this:A person with emphysema is like this: Inhale all the way, then exhale a little bit, and Inhale all the way, then exhale a little bit, and

hold it. Now inhale and exhale to that same hold it. Now inhale and exhale to that same point.point.

They cannot exhale all the way. They start They cannot exhale all the way. They start using their abdominal and thoracic muscles, using their abdominal and thoracic muscles, and get a large, barrel chest.and get a large, barrel chest.

They have chronic acid-base balance problems, They have chronic acid-base balance problems, and the kidneys have to work harder. They and the kidneys have to work harder. They usually develop kidney problems.usually develop kidney problems.

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SmokingSmoking If a person stops smoking after 10 years, damage If a person stops smoking after 10 years, damage

will repair. Longer than 10 years may have some will repair. Longer than 10 years may have some residual damage. Smoking 20+ years is more residual damage. Smoking 20+ years is more likely to cause emphysema.likely to cause emphysema.

It takes 7 years for lungs to repair. It takes 7 years for lungs to repair. Smoking right after exercise is worse because Smoking right after exercise is worse because

you are breathing more deeply. you are breathing more deeply. Pollution in the air can also cause particles in the Pollution in the air can also cause particles in the

lungs, and the ozone can damage the lungs. lungs, and the ozone can damage the lungs. Living in Southern California is like smoking one Living in Southern California is like smoking one pack a day. pack a day.

A mother who smokes during pregnancy will have A mother who smokes during pregnancy will have a baby with a lower birth weight.a baby with a lower birth weight.

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Smoking Smoking Smoking also is associated with heart Smoking also is associated with heart

disease, cancer of the lung, bladder, disease, cancer of the lung, bladder, and pancreas. and pancreas.

It also causes emphysema, It also causes emphysema, pneumonia, and bronchitis. pneumonia, and bronchitis.

Some people try to quit smoking by Some people try to quit smoking by smoking less, trying not to inhale, or smoking less, trying not to inhale, or switching to chewing tobacco, but switching to chewing tobacco, but there is no safe way to use tobacco.there is no safe way to use tobacco.

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New hope for smokers who New hope for smokers who want to quit: Electronic want to quit: Electronic

CigarettesCigarettes These are actually water These are actually water

vapor sticks…it looks and vapor sticks…it looks and feels like smoking, but it feels like smoking, but it is non-toxic water vapor. is non-toxic water vapor.

Comes in various flavors Comes in various flavors (tobacco, vanilla, fruit), (tobacco, vanilla, fruit), and various levels on and various levels on nicotine, from zero to nicotine, from zero to strong.strong.

Greensmoke.comGreensmoke.com

Each cartridge has enough liquid to equal 1.5 packs of cigarettes.

http://www.ejuiceusa.com/

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Good Starter KitGood Starter Kit

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Start with tobacco flavor and high nicotine strength.

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9494

More advanced kit: battery and juice last all day. This is the tank.

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This is the battery.

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This is the battery charger.

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Marijuana VaporizerMarijuana Vaporizerhttp://www.vaporseller.com/pinnacle-pro-portable.html?http://www.vaporseller.com/pinnacle-pro-portable.html?

___store=default&gclid=Cj0KEQjwt7KiBRD9lOePpe_BhrgBEiQAHaS_1-___store=default&gclid=Cj0KEQjwt7KiBRD9lOePpe_BhrgBEiQAHaS_1-Vqq_WZR3ZYR-MfMH-ipcu1VOtQoIiaITcVRVLLzr0aAk358P8HAQ Vqq_WZR3ZYR-MfMH-ipcu1VOtQoIiaITcVRVLLzr0aAk358P8HAQ

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PneumoniaPneumonia

An infectious illness that results in An infectious illness that results in the accumulation of fluid in the the accumulation of fluid in the alveoli.alveoli.

Pneumococcal pneumonia Pneumococcal pneumonia kills about kills about 1 out of 20 people who get it.1 out of 20 people who get it.

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MRI of Lungs with NodulesMRI of Lungs with Nodules

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Respiratory DisordersRespiratory Disorders Upper Respiratory Infection (URI)Upper Respiratory Infection (URI)

Lungs are not involvedLungs are not involved Usually caused by a cold virus or allergiesUsually caused by a cold virus or allergies Usually not associated with a fever (antibiotics Usually not associated with a fever (antibiotics

don’t work)don’t work) Lower Respiratory Infection (LRI)Lower Respiratory Infection (LRI)

Lungs are involvedLungs are involved Usually caused by bacteriaUsually caused by bacteria Usually associated with a fever (antibiotics work)Usually associated with a fever (antibiotics work)

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Other Lung ConditionsOther Lung Conditions

INFLUENZAINFLUENZA LUNG CANCER LUNG CANCER RESPIRATORY DISTRESS RESPIRATORY DISTRESS

SYNDROMESYNDROME TUBERCULOSISTUBERCULOSIS CYSTIC FIBROSISCYSTIC FIBROSIS

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INFLUENZAINFLUENZA

This is the “flu” caused by a virus. This is the “flu” caused by a virus. This is what you are vaccinated This is what you are vaccinated

against when you get the flu vaccine.against when you get the flu vaccine. No risks seen with flu shot in early

pregnancy http://fxn.ws/Otmu86

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LUNG CANCERLUNG CANCER

There are many types of lung There are many types of lung cancers. About 150,000 die each cancers. About 150,000 die each year from them.year from them.

It is the #2 most deadly form of It is the #2 most deadly form of cancer.cancer.

85% of lung cancer is caused from 85% of lung cancer is caused from smoking.smoking.

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LUNG CANCERLUNG CANCER

The problem is that it starts as a hard nodule The problem is that it starts as a hard nodule deep in the spongy tissue of the lung, where deep in the spongy tissue of the lung, where it has no symptoms until it presses against a it has no symptoms until it presses against a structure. By then, it has also metastasized. structure. By then, it has also metastasized.

Surgery on a smoker won’t work because the Surgery on a smoker won’t work because the lungs are too weak, and they can’t do lungs are too weak, and they can’t do without the lung tissue. There are no good without the lung tissue. There are no good screening procedures for lung cancer.screening procedures for lung cancer.

In lung cancer, the cancer cells usually arise In lung cancer, the cancer cells usually arise from the epithelium lining a large bronchus.from the epithelium lining a large bronchus.

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Lung Cancer SurgeryLung Cancer Surgery

Lobectomy VIDEOLobectomy VIDEO

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RESPIRATORY DISTRESS RESPIRATORY DISTRESS SYNDROMESYNDROME

SURFACTANTSURFACTANT is a detergent is a detergent produced within the alveoli, which produced within the alveoli, which coats it. coats it.

It functions to help with lung inflation It functions to help with lung inflation by keeping the walls of the alveoli by keeping the walls of the alveoli from sticking together when they from sticking together when they collapse during exhalation. collapse during exhalation.

If you have two wet pieces of paper If you have two wet pieces of paper and stick them together, they are hard and stick them together, they are hard to pull apart without ripping. Put to pull apart without ripping. Put soapy water between them, and you soapy water between them, and you can pull them apart.can pull them apart.

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RESPIRATORY DISTRESS RESPIRATORY DISTRESS SYNDROMESYNDROME

Surfactant is not produced in a fetus until the Surfactant is not produced in a fetus until the ninth month, so premature babies don’t have ninth month, so premature babies don’t have enough surfactantenough surfactant RESPIRATORY RESPIRATORY DISTRESS SYNDROMEDISTRESS SYNDROME, which is the #1 , which is the #1 cause of death in premature babies. cause of death in premature babies.

You know how hard it is to blow up a brand You know how hard it is to blow up a brand new balloon? Imagine a baby having to do new balloon? Imagine a baby having to do that with every single breath. You get tired. that with every single breath. You get tired.

The treatment is to spray artificial surfactant The treatment is to spray artificial surfactant into the lungs, and put them on a respirator into the lungs, and put them on a respirator to push air in. The more distal regions are to push air in. The more distal regions are still collapsed, so there are problems.still collapsed, so there are problems.

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TUBERCULOSISTUBERCULOSIS

An infection of a really bad bacteria that An infection of a really bad bacteria that get in the lungs and make themselves a get in the lungs and make themselves a capsule to hide in, where antibiotics can’t capsule to hide in, where antibiotics can’t reach. They set up shop in the lungs and reach. They set up shop in the lungs and reproduce. Soon, the lungs fill up with these reproduce. Soon, the lungs fill up with these hard nodes and make it difficult to breathe. hard nodes and make it difficult to breathe. It causes extreme coughing, and then lots It causes extreme coughing, and then lots of these bacteria break off and get spewed of these bacteria break off and get spewed into the air, where someone else can inhale into the air, where someone else can inhale them. It is extremely contagious and very them. It is extremely contagious and very deadly. deadly.

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TUBERCULOSISTUBERCULOSIS If a person gets TB, the State Health Department has to be If a person gets TB, the State Health Department has to be

notified.notified. If it is active TB, you must be hospitalized.If it is active TB, you must be hospitalized. If it is not an active infection, you still need medicines.If it is not an active infection, you still need medicines. They will show up at your house every morning for six They will show up at your house every morning for six

months and stand there and watch you take your pills. months and stand there and watch you take your pills. If you don’t accept this, they have the right to haul you away If you don’t accept this, they have the right to haul you away

to a lock-up facility and force the medicine in you for six to a lock-up facility and force the medicine in you for six months. months.

There are only a few diseases where the State Health There are only a few diseases where the State Health Department will step in like this: anthrax, small pox, swine Department will step in like this: anthrax, small pox, swine flu, typhoid fever, bubonic plague, and Ebola virus are other flu, typhoid fever, bubonic plague, and Ebola virus are other diseases where you don’t get a choice; you are forced into diseases where you don’t get a choice; you are forced into isolation. Diseases like TB and the plague have almost wiped isolation. Diseases like TB and the plague have almost wiped out Europe!out Europe!

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Positive TB skin testPositive TB skin test

http://www.visualsunlimited.com/111111

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TUBERCULOSISTUBERCULOSIS

A TB test will be positive if you have been A TB test will be positive if you have been exposed to the organism at any point in your life. exposed to the organism at any point in your life.

Then you’ll have to go in for an x-ray to see if it is Then you’ll have to go in for an x-ray to see if it is an active case of TB or not. an active case of TB or not.

Once you recover from TB you will always have a Once you recover from TB you will always have a positive TB test, so tell the nurse that in advance. positive TB test, so tell the nurse that in advance.

You may have to provide documentation that you You may have to provide documentation that you have been treated for it already.have been treated for it already.

Most employers require TB tests before hiring. I Most employers require TB tests before hiring. I had to take one to work here.had to take one to work here.

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CYSTIC FIBROSISCYSTIC FIBROSIS

Cystic fibrosis is an Cystic fibrosis is an inherited disease that inherited disease that causes thick, sticky causes thick, sticky mucus to build up in mucus to build up in the lungs and the lungs and digestive tract. It is digestive tract. It is one of the most one of the most common type of common type of chronic lung disease in chronic lung disease in children and young children and young adults, and may result adults, and may result in early death.in early death.

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CYSTIC FIBROSISCYSTIC FIBROSIS Millions of Americans carry the defective CF Millions of Americans carry the defective CF

gene, but do not have any symptoms. That's gene, but do not have any symptoms. That's because a person with CF must inherit two because a person with CF must inherit two defective CF genes -- one from each parent. defective CF genes -- one from each parent. An estimated 1 in 29 Caucasian Americans An estimated 1 in 29 Caucasian Americans have the CF gene. The disease is the most have the CF gene. The disease is the most common, deadly, inherited disorder common, deadly, inherited disorder affecting Caucasians in the United States. affecting Caucasians in the United States. It's more common among those of Northern It's more common among those of Northern or Central European descent.or Central European descent.

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CYSTIC FIBROSISCYSTIC FIBROSIS

Most children with CF are diagnosed by Most children with CF are diagnosed by age 2. A small number, however, are not age 2. A small number, however, are not diagnosed until age 18 or older. These diagnosed until age 18 or older. These patients usually have a milder form of patients usually have a milder form of the disease.the disease.

Having CF offers some protection from Having CF offers some protection from typhoid fever and cholera, in the same typhoid fever and cholera, in the same way that sickle cell anemia protects way that sickle cell anemia protects against malaria.against malaria.

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Choking Hazards for Choking Hazards for ChildrenChildren

http://www.kidsdr.com/daily-dose/hot-dogs-a-choking-hazard

Tonsillectomy VIDEO

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