respimat ® dry inhaler technology
TRANSCRIPT
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RESPIMAT dry inhaler
technology
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What is Respimat Soft Mist
Inhaler?Respimat soft mist inhaler (SMI) is propellent Free
inhaler by Boehringer Ingelheim as innovative approach
to inhalation therapy.
Respimat soft mist inhaler helps to improve lung
disposition is easy to use and preferred by patients than
conventional MDI and DPIs
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Benefits of respimat SMI innhaler Results
Unique soft mist resulting in decreased in
Cloud velocity
Less impaction in the oropharynx
decreased cloud velocity*
Unique soft mist resulting in
increased cloud duration
Simplifies co-ordination of activation
with inspiration
Increased lung deposition Better drug targeting, allowing
reduction of the nominal dose
Propellant-free Less impact on the environment
Easy to use * Simple for the patient
High fine particle fraction Greater amount of respirable particles
Why respimat inhaler useful???
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Key features of Respimat soft mist
inhaler
1) High Fine-Particle Fraction :The RESPIMAT inhaler generates a medicationcloud with a high fine-particle fraction (FPF). The size of drug particles is a keyfactor in ensuring penetration of the medication into lungs.
2) Long Cloud Duration:The RESPIMAT inhaler has demonstrated a longer cloud
duration than pressurized metered dose inhalers (pMDIs)RESPIMAT inhaler mean cloud duration: 1.5 seconds
pMDI cloud duration: 0.15 to 0.36 seconds
3) Slow-Moving Aerosol Cloud :The RESPIMAT inhaler has demonstrated a slowercloud velocity (mean 0.8 m/sec) relative to pMDIs (range 2.0 m/sec to 8.4
m/sec).4) Consistent Drug Dose : The RESPIMAT inhaler delivers a consistent drug dose
throughout the life span of the cartridge.
5) Higher Lung Deposition :achieve high therapeutic effect compared with othertypes of inhalers.
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No Propellant :
The RESPIMAT inhaler contains no chlorofluorocarbons
(CFCs). This eliminates the problems associated with thevolatile propellants in pMDIs.
Multidose Canister :
The RESPIMAT inhaler cartridge delivers 120 metered
actuations after preparation and priming for first-time use.The RESPIMAT inhaler includes a dose indicator combined
with a locking mechanism that engages when the dose
indicator has reached the end of the scale (after 120
actuations).
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External components of Respimat inhaler
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Internal components of Respimat
inhaler
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HOW IT WORKS?
A 180 twist of the device base compresses the spring.
This draws a metered dose of drug solution through the
capillary tube to the dosing chamber
When the dose release button is pressed, the power from the spring
moves the capillary tube into the dosing chamber The drug solution is forced through the uniblock
The uniblock produces two fine jets of liquid that converge at a selected
angle and then collide.
The collision aerolizes the liquid to form a slow-moving cloud of
inhalable particles, the Soft Mist
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Storage conditions for Respimat
inhaler
Store RESPIMAT inhaler at Room Temperature
between 59F to 86F (15C to 30C).
Do not freeze your RESPIMAT cartridge and inhaler.
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Marketed formulations:
Combivent respimat inhaler: It contains ipratonium and albuterol astwo bronchodilators for treatment of bronchitis and ephysema.
Dosing:2 inhalations 4 times daily.
Spiriva respimat inhaler: It contains tiotripium (long actingmuscarinic receptor antagonist) 2.5 micrograms per actuation.it is used
for COPD diseases.
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Advantages:
No propellant
Slow moving medicament cloud
Consistent drug dose Cloud with high particle fraction
Dose indicator
Higher lung disposition than pMDIs
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Disadvantages
Not available in most countries.
Not breath actuated.
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Conclusion:
Respimat inhaler is efficient technology as
pulmonary drug delivery system .
It has higher lung disposition of drug .
No propellants are used so, it is environmental
friendly
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Referances:
1) www.google.com
2) www.wikipedia.in
http://www.google.com/http://www.wikipedia.in/http://www.wikipedia.in/http://www.google.com/ -
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