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A monthly research awareness e-Journal by

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Volume 2 Issue: 5 (May 2013) | Page: 36 - 43

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Chief Editor

Dr. Saurav Arora

Editorial Advisory Board

Dr. José Eizayaga (Argentina)

Dr. Silvia Waisse (Brazil)

Dr. Leoni Bonamin (Brazil)

Dr. Shivang Swaminarayan (India)

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Table of Contents Studies you may like to read ....................................................................................................................37

Clinical Research .........................................................................................................................................37

1. An Open Label Pilot Study Testing The Role Of Classical Homeopathy In Chronic Allergic Rhinitis ................................................................................................................. 37

2. Efficacy of individualized homeopathic treatment and fluoxetine for moderate to severe depression in peri- and postmenopausal women (HOMDEP-MENOP): study protocol for a randomized, double-dummy, double-blind, placebo-controlled trial. .. 37

3. Accelerating the healing of bone fracture using homeopathy: a prospective, randomized double-blind controlled study .................................................................... 38

4. Evidence based homoeopathy in treating condyloma acuminatum – a prospective and interventional study .......................................................................................................... 39

Drug Standardization ................................................................................................................................39

1. Acalypha indica L - an Important Medicinal Plant: a Review of Its Traditional Uses, and Pharmacological Properties ...................................................................................... 39

2. Regulatory Standards on Homoeopathic Drugs: Indian Perspective ........................... 39

3. Homeopathic drug proving of Okoubaka aubrevillei: a randomised placebo-controlled trial ..................................................................................................................................... 40

4. Chelidonium majus l. - a review on pharmacological activities and clinical effects .... 41

Veterinary Research...................................................................................................................................41

1. Homeopathic studies in veterinary medicine A collection by Gaby Rottler ................. 41

Public Health ................................................................................................................................................41

2. Unification of Indian Systems of Medicine and Homoeopathy Policy and National Health Policy in India-Stakeholders' Perspective ........................................................... 41

News ................................................................................................................................................................42

Events ..............................................................................................................................................................42

37

Studies you may like to read

Clinical Research

An Open Label Pilot Study Testing The Role Of Classical Homeopathy In Chronic Allergic Rhinitis

Shubhamoy Ghosh*, Satadal Das, Malay Mundle,

Dishari Sengupta, Sk. Intaj Hossain, Munmun

Koley and Subhranil Saha

IJPSR, 2013; Vol. 4(4): 1475-1484.

Free Text Available

Purpose: The prevalence of allergic rhinitis (AR)

is increasing at an alarming rate throughout the

world. India has an estimated number of 15-20

million patients with allergic bronchial asthma

and 30-80% of these suffer from AR. So, AR is

considered as a major chronic respiratory disease

due to its prevalence, impact on quality of life

(QoL), work/school performance and

productivity, economic burden and links with

asthma. This research aims at testing the role of

classical homeopathy in bringing changes in

serum immunoglobulin E (IgE) level and absolute

eosinophil count (primary outcome measures)

and symptoms score and WHOQOL-BREF score

related to AR (secondary outcome measures) by

comparing the pre-trial and post-trial data.

Method: An open label, single arm, experimental,

prospective, non-randomized, non-controlled,

before and after comparison pilot study was

carried on 34 participants suffering from chronic

AR. Institutional ethical clearance was obtained;

then thirty four consenting patients were

enrolled after screening of 58 patients by

eligibility criteria and were allocated to classical

homeopathic treatment. Four cases were drop-

outs; thirty cases were regular. Outcome

measures were assessed and analyzed after one

year.

Results: After one year of homeopathic

treatment, lowering of serum IgE level

(1006.83±395.17 vs 336.5±126.96; P = 0.0000),

absolute eosinophil count of blood

(600.33±103.61 vs 302.5±82.21; P = 0.0000) and

AR symptoms score (30.27±5.12 vs 12.83±2.72; P

= 0.0000) and increase in WHOQOL-BREF scores

of AR (58±7.01 vs 87.7±6.18; P = 0.0000) were

statistically highly significant. No adverse effects

and/or complications were observed. Most

commonly used constitutional and acute

remedies were Natrum muriaticum and

Histamine hydrochloride respectively in different

centesimal potencies.

Conclusion: Data suggest that classical

homeopathic treatment may be a useful measure

for the patients suffering from chronic AR.

However, multi-centric randomized controlled

trials with larger sample size should be

undertaken for making firm recommendations.

Efficacy of individualized homeopathic treatment and fluoxetine for moderate to severe depression in peri- and postmenopausal women (HOMDEP-MENOP): study protocol for a randomized, double-dummy, double-blind, placebo-controlled trial. Trials 2013, 14:105

Emma del Carmen Macías-Cortés, Leopoldo

Aguilar-Faisal, Juan Asbun-Bojalil

Free Text Available

Background

The perimenopausal period refers to the interval

when women's menstrual cycles become

irregular and is characterized by an increased

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risk of depressive symptoms. Use of homeopathy

to treat depression is widespread but there is a

lack of clinical trials about its efficacy in

depression in peri- and postmenopausal women.

Previous trials suggest that individualized

homeopathic treatments improve depression. In

classical homeopathy, an individually selected

homeopathic remedy is prescribed after a

complete case history of the patient. The aim of

this study is to assess the efficacy and safety of

the homeopathic individualized treatment versus

placebo or fluoxetine in peri- and

postmenopausal women with moderate to severe

depression.

Methods/design

A randomized, placebo-controlled, double-blind,

double-dummy, three-arm trial with a six week

follow-up study was designed. The study will be

conducted in a public research hospital in Mexico

City (Juárez de México Hospital) in the outpatient

service of homeopathy. One hundred eighty nine

peri- and postmenopausal women diagnosed

with major depression according to the

Diagnostic and Statistical Manual of Mental

Disorders, 4th edition (moderate to severe

intensity) will be included. The primary outcome

is change in the mean total score among groups

on the 17-item Hamilton Rating Scale for

Depression after the fourth and sixth week of

treatment. Secondary outcomes are: Beck

Depression Inventory change in mean score,

Greene's Scale change in mean score, response

and remission rates and safety. Efficacy data will

be analyzed in the intention-to-treat population.

To determine differences in the primary and

secondary outcomes among groups at baseline

and weeks four and six, data will be analyzed by

analysis of variance for independent measures

with the Bonferroni post-hoc test.

Discussion

This study is the first trial of classical

homeopathy that will evaluate the efficacy of

homeopathic individualized treatment using C-

potencies versus placebo or fluoxetine in periand

postmenopausal women with moderate to severe

depression. It is an attempt to deal with the

obstacles of homeopathic research due to the

need for individual prescriptions in one of the

most common psychiatric diseases.

Accelerating the healing of bone fracture using homeopathy: a prospective, randomized double-blind controlled study

BMC Complementary and Alternative Medicine

2012, 12(Suppl 1):O61

S Sharma*, N Sharma, R Sharma

Free Text Available

Purpose

In clinical practice, homeopathy is widely used in

the fracture-repair process, which accelerates the

healing of fractures, enhances callus formation

and reduces pain. But there is no anatomical or

scientific evidence yet to prove that. Therefore,

the current study was undertaken to test the

efficacy of homoeopathy in bone fracture healing.

Methods

The study was conducted as a double blind

randomized controlled study with 67patients

with acute non-displaced lateral malleolar

fracture. Patients were recruited from the

Emergency Orthopaedic department, SMS

Hospital, Jaipur, India during May 2007 to May

2009. Patients were randomized to either a

homoeopathy treatment (n=34) or a control

group (n=33). All the patients received standard

orthopaedic care through 12 weeks following

injury. The treatment group received

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homoeopathic medicine on the basis of totality of

symptoms and individualisation. Outcome

measures include radiological assessments and

functional tests for healing.Assessments were

taken on 3, 6, 9 and 12 weeks.

Results

Faster healing was reported in the homeopathy

group by week 9 following injury, including

significant improvement

in fracture line (p < 0.0001), fracture edge

(p<0.0001), callous formation (p< 0.05) and

fracture union (p< 0.0001) in comparison to

placebo. There was also lower use of analgesics

and less self-reported pain in the homeopathy

group.

Conclusion

The study suggests that homoeopathy could

enhance anatomical and functional fracture

healing.

Evidence based homoeopathy in treating condyloma acuminatum – a prospective and interventional study Chandra nath das

Free Text Available

Condyloma acuminatum is one of the most

prevalent sexually transmitted disease in the

western countries and India. It may hamper

personal life of individual. Human papilloma

virus ( HPV) , subtype 6 & 11 are responsible for

the disease .This case study is a prospective and

intervention to combat long standing condyloma

acuminatum by Homoeopathy.

Keywords: Condyloma Acuminatum,

Homoeopathy, Prospective & Interventional

Study.

Drug Standardization

Acalypha indica L - an Important Medicinal Plant: a Review of Its Traditional Uses, and Pharmacological Properties

Free Text Available

International Journal of Research in Botany

2013; 3(1): 19-22

D.Jagatheeswari, J.Deepa, H.Sheik Jahabar Ali

and P. Ranganathan*

Abstract

Medicinal herbs are moving from fringe to

mainstream use with a greater number of people

seeking remedies and health approaches free

from side effects caused by synthetic chemicals.

India officially recognizes over 3000 plants for

their medicinal value. It is generally estimated

that over 6000 plants in India are in use in

traditional, folk and herbal medicine. This article

aims to provide a comprehensive review on the

and pharmacological aspects of Acalypha indica.

It is obtained from deciduous and mixed-

monsoon forests throughout greater parts of

India, ascending to 1300 m in outer Himalaya, is

widely used in traditional medicinal system of

India has been reported to possess

hepatoprotective, anti-inflammatory, antitussive,

antifungal and also used to check wounds healing

and antibacterial. It is known as a rich source of

tannins, flavanoids and glycosides. The

innumerable medicinal properties and

therapeutic uses of Acalypa indica as well as its

phytochemical investigations prove its

importance as a valuable medicinal plant.

Regulatory Standards on Homoeopathic Drugs: Indian Perspective International Journal of Advanced

Pharmaceutical Science and Technology 2013,

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Volume 1, Issue 1, pp. 1-20, Article ID Sci-72

Lalit Tiwari, Nitin Rai and Rajeev Kr Sharma

Free Text Available

The Pharmacopoeia is the official compendium of

a country related to regulatory standards of

drugs manufactured and practiced in the political

zone of that country. The pharmacopoeial

standards are experimentally established and

work as yardstick to ensure the quality safety and

efficacy of a drug. These are approved standards

and vetted by duly constituted bodies to

incorporate in a pharmacopoeia. In broad term,

the pharmacopoeia is a book of standards

applicable to drug substance and their dosage

forms of common usage in a country.

Pharmacopoeia is prepared by recognized

authority appointed by the Government of a

particular country with a few exceptions eg. USP.

In India, Homoeopathic System of Medicines has

its own pharmacopoeia titled as Homoeopathic

Pharmacopoeia of India (HPI). So far, nine

volumes of HPI are published from 1971 to 2006

which covers total 919 monographs of

Homoeopathic single drugs.

Homeopathic drug proving of Okoubaka aubrevillei: a randomised placebo-controlled trial

Trials 2013, 14:96

Michael Teut, Joern Dahler, Ute Hirschberg,

Rainer Luedtke, Henning Albrecht, Claudia M Witt

Free Text Available

Background

Homeopathic drug proving is a basic concept in

homeopathy. This study aimed to record

symptoms produced by a homeopathic drug

compared with placebo.

Methods

This multicentre, randomised, double-blind,

placebo-controlled phase 1 trial consisted of a 7-

day run-in period, a 5 day intervention period

and a 16-day post-intervention observation

period. Subjects, investigators and statisticians

were blinded for intervention groups and identity

of the homeopathic drug. Subjects in the

intervention group received Okoubaka

aubrevillei (potency C12) and subjects in the

placebo group received the optically identical

sucrose globules. Dosage in both groups was five

globules taken five times per day over a

maximum period of 5 days. Subjects documented

the symptoms they experienced in a

semistructured online diary. The primary

outcome parameter was the number of

characteristic proving symptoms compared with

placebo after a period of 3 weeks. Characteristic

symptoms were categorised using content

analysis. Secondary outcome parameters were

the qualitative differences in profiles of

characteristic and proving symptoms and the

total number of all proving symptoms. The

number of symptoms was quantitatively analysed

on an intention-to-treat basis using analyses of

covariance with the subject's expectation and

baseline values as covariates.

Results

Thirty-one subjects were included (19 Okoubaka

and 12 placebo). Data for 29 participants could be

analysed. No significant differences in number of

characteristic symptoms in both groups were

observed between Okoubaka (mean ± standard

deviation 5.4 ± 6.0) and placebo (4.9 ± 5.6). The

odds ratio for observation of a characteristic

symptom was 1.11 (95% confidence interval 0.4

to 3.05, P = 0.843). Females and subjects

expecting a higher number of symptoms at

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baseline or feeling more sensitive to homeopathic

drugs experienced more characteristic symptoms

regardless of allocation. The qualitative analysis

showed an intercoder reliability of 0.69 (95%

confidence interval 0.62 to 0.76). The qualitative

comparison of symptom profiles was

inconclusive.

Conclusions

Combined results of qualitative and quantitative

methods did not result in a significant difference

of characteristic proving symptoms between O.

aubrevillei C12 and placebo. The qualitative

comparison of the symptom profiles leaves some

open questions. The nocebo effect might be a

plausible explanation for most of the phenomena

observed in this trial.

Chelidonium majus l. - a review on pharmacological activities and clinical effects Biswas Surjyo Jyoti

Free Text Available

Chelidonium majus L. (Papaveraceae) is a plant

that has been used for centuries in treating many

diseases in European and Asian countries. Crude

extracts from various parts of the plant contain

isoquinoline alkaloids. The alkaloids derived from

C. majus have not yet much studied; however,

some reports are available on toxicity studies of

alkaloids of this plant. In such a scenario there is

need for understanding its therapeutic potential

and its toxic actions. This review summarizes

scientific findings and suggests areas where

further research is needed.

Keywords: Chelidonium majus, alkaloids,

pharmacology, antioxidant

Veterinary Research

Homeopathic studies in veterinary medicine A collection by Gaby Rottler

Free Text Available

Public Health

Unification of Indian Systems of Medicine and Homoeopathy Policy and National Health Policy in India-Stakeholders' Perspective

Balpreet Singh*, Amarjeet Singh and Manoj

Kumar

Free Text Available

AIM: India has designed National Policy on Indian

systems of Medicine and Homeopathy (ISM&H

Policy) in 2002 to emphasize the development of

Ayurveda, Siddha, Unani, Yoga, Naturopathy and

Homoeopathy due to public patronage of these

systems. Currently India has two health related

policies, National Health Policy and ISM&H Policy.

This study proposes to look into the need of

eventual fusion of these policies for better

healthcare.

METHODS: An online questionnaire was

designed to assess the views of Public Health

experts and mailed to 100 experts. The tool was

tested for content validity and a pilot study was

done to find out the feasibility of the study. Study

period was September 2010 to May 2011. The

data was analysed with the help of Microsoft

Excel 2007 represented as percentages.

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RESULTS: 58 out of 100 experts responded to

questionnaire. 67% of respondents favored

formation of unified health policy. Most

mentioned reason for unified policy was

'common goal of health' of all system followed by

'strengthening of health system' and 'equal status

and growth of all health systems'. Respondents

disfavoring the concept of unified health policy

opined that all health systems have different

principles which can be dealt by separate policy.

CONCLUSION: Majority of respondents opined

that ISM& H Policy should be merged to form

unified health policy as health is a complete

concept in itself and should be viewed in

multidisciplinary approach.

Key words: India, medicine, homoeopathy policy.

News Complementary medicines expert dismissed from homeopathy journal

Homeopathy lacks any hard evidence

Press council wades into medical evidence debate

No doctors, infrastructure for Homeopathy hospitals

Homeopathy Day celebrated

Diluting the scientific method: Ars looks at homeopathy (again)

Homeopathy on the NHS is 'mad' says outgoing scientific adviser

Parents need to know homeopathy does not protect against measles, says MP

Events

May 2, 2013

Dr Kalathia's Systematic Approach in Homeopathy - Modern Interpretation

9:00 am – 12:30 pm

Webinar: 3 Hours 30 Minutes (Repeats Every 7 Days Until June 30, 2013)

Module 1: An explicit explanation of the main Kingdoms in Homeopathy with their subcategories.

Module 2: Scientific but artistic Case Taking, Case Analizing and Case Menagement

HomeoHelp Holistic School's virtual classroom

Rumen Stoychev info@homeohelp.eu

May 2 – May 5, 2013

BREAK THROUGH CONCEPTS- transforming patient stories and innovative case-taking techniques

Speakers: Bhawisha and Shachindra Joshi

Hosted & Sponsored by Stellar Seminars

Contact: Sonam Kushner- sosimilar@aol.com

Marina Braun- aquamarinabr@gmail.com

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May 5, 2013

Dr. Kishore Mehta winner of best teacher award and world renowned teacher, will share his novel way

to approach to Homoeopathic Materia Medica, through demonstration of NATRUM MURIATICUM.

For Details and registration kindly click the link below;

http://us2.campaign-archive1.com/?u=b7a07e78278262bc324cc8b90&id=3e01540784

May 13, 2013

AMCH – MODERN PRACTICE

5:00 - 7:00 pm pacific time

Karen Allen, Iris Bell, Miranda Castro, Jerry Kantor, Amy Lansky, Todd Rowe and Gabrielle Traub

Contact: Leslie at 714-577-8853 or email whncourses@whnow.com

May 15, 2013

NCH Webinar - Homeopathy as a Form of Nanomedicine: What the Latest Research Shows

NCH Member Webinar

Wednesday, May 15, 2013; 8-9PM EDT

The homeopathic community is a-buzz with excitement about the rapidly expanding field of

nanomedicine and current research into homeopathic remedies. If you are interested in learning more

about the relationship between nanomedicine and homeopathy, then you won't want to miss this

webinar.

Join Dr. Iris Bell, a Research Professor at the University of Arizona College of Nursing and a member of

the research faculty of the American Medical College of Homeopathy, for an overview of the scientific

evidence indicating that homeopathic remedies contain nanoparticles of their source materials and the

implications of this evidence for clinical care.

As always, this webinar is free to all NCH members, but space is limited - so register today!

Website: www3.gotomeeting.com/register/294732774

May 17 –May 19, 2013

Prep for CHC and other Homeopathic Certification Exams

Lauri Grossman, Lucy Vaughters Kenmore WA

info@seattleschoolofhomeopathy.com

425-672-4485

May 19, 2013

FREE ONLINE SESSION: Nosodes - Themes and a Case by Dr. Kalathia

ENROLL FOR FREE - http://homeohelp.eu/en/enroll.html

Contact Skype "homeohelpeu" or school@homeohelp.eu