M Olivia HarrisSenior Environmental Health Scient ist

NCEH/ATSDR Office of ScienceOharris@cdc.gov

Research Translat ion in Act ion:

Building Relat ionships

between

SRP and NCEH/ATSDR Scient ists

Agency for Toxic Substances and Disease RegistryNational Center for Environmental Health

Perspect ive from the joint ly managed

Agency for Toxic Substances and Disease Registry(Superfund hazardous waste sites)

ht tp://www.atsdr.cdc.gov/

&

National Center for Environmental Health(exposures from all sources) ht tp://www.cdc.gov/nceh/

SRP Purpose

Fund mult i-disciplinary research which

Environmental Managers & Risk Assessors(such as ATSDR Scient ists)

Can USEto make decisions

about Superfund & other Hazardous Waste Sites.

To Facilitate Research Translat ion,NIEHS Encourages SRP grantees to form Partnerships with

NCEH/ATSDR ATSDR State Cooperat ive Agreement Partners

Region 4 EPA

SO

We have Prompt Access to SRP Research

SRP Grantees have Feedback on our RESEARCH Needs

Building Relat ionships between NCEH/ATSDR Scient ists & SRP Grantees

WE can’t work with YOU

IF

WE don’t know YOU….(OR know your expert ise)

A Research Translat ion Strategy that Works

Seminar & Networking Opportunity at NCEH/ATSDR

NCEH/ATSDR Scient ists

Get to Know

SRP grantee scient ists

So we learn what Tools & Expert ise SRP has to HELP US

SRP Grantee Visits NCEH/ATSDR for a Day

Seminar

Networking Lunch with Staff

Office Hours with Staff

Seminar Audience

NCEH/ATSDRRegion 4 EPA

Emory Medical Toxicology Program traineesCDC (including NIOSH)

Online (LiveMeeting):ATSDR State Cooperat ive Agreement Partners

ATSDR Regional Offices

Low pressure format for NCEH/ATSDR Scient ists

from diverse Environmental Health Disciplines

to Explore Mutual Interests

with SRP Scient ists

One on One Interact ionsMay Catalyze

Faster use of Basic Research Insights in Applied Environmental

Public Health Pract ice

Many desired outcomes are not easily quant ified.

NCEH/ATSDR learns about new developments in basic science

DHAC/ATSDR has used information gained from the seminars & individual meet ings in their Public Health Assessments

SRP grantees learn about NCEH/ATSDR programs, research, and research needs.

Scient ific networking connect ions made for future use

Collaborat ions & cooperat ion are considered

The Zenith of Success

Collaborat ions are Easily Counted Outcomes

But

Should not be the Only Metric for Evaluat ing

this Research Translat ion Act ivity

New Collaborat ions Developed: I

Jim Swenberg, University of North Carolina-Chapel Hill&

Protein Biomarker Lab/NCEH

NCEH chemists analyzed acrylamide and glycidamide hemoglobin adducts as biomarkers of exposure for a case control study on brain tumors.

Jim Swenberg’s lab measured butadiene hemoglobin adducts in the same study. The data are current ly being analyzed.

New Collaborat ions Developed : II

Clem Furlong, University of Washington&

Emergency Response & Air Toxicants Branch/NCEH

Development of Novel Blood Biomarkers to aid in diagnosing human exposure to

Cholinesterase Inhibitors

[bioterrorism agents, organophosphate insect icides, organophosphate ester addit ives to lubricants and

hydraulic fluids]

Potent ial Collaborat ions Incubating Now

Grant proposal ideas being kicked around.

NCEH scient ists were contacted by an epidemiologist from a non-SRP inst itut ion.

“ If we hadn’t met this SRP grantee when he visited, we wouldn’t have thought of including him when brainstorming about study design.”

Challenges

Lack Funding to follow through on all

Ideas for Potent ial Collaborat ions between SRP grantees & NCEH/ATSDR

NCEH/ATSDR scient ists ask: Will SRP

Fund some collaborat ions?Provide some seed money to start pilot projects?

Thank YOU!!!SRP & SRP grantees

for funding &

part icipat ing in this Research Translat ion Act ivity!

2007- 2010 SRP Part icipants

University of North Carolina-Chapel Hill

Frederic K. PfaenderBioavailability as a Factor in Pollutant Exposure

Leena A. Nylander-FrenchPharmacokinet ics of the Interact ion between Inhaled &

Dermal Absorpt ion of Naphthalene, an Environmental PAH

James A. SwenbergBiomarkers of Exposure and Effect: Implicat ions for Risk

Assessment

Duke University & University of Colorado-BoulderKarl G. Linden

From PAHs to Organophosphates: Photolyt ic Fate in Engineered & Natural Systems

University of California-BerkeleyJames R. Hunt

Dense Brines as Sources of Groundwater Contaminat ion by Perchlorate & Chromate

Columbia UniversityTom K. Hei

The How and Why of Asbestos Carcinogenesis

University of WashingtonClement Furlong

Biomarkers of Exposure & Paraoxonases as Biomarkers of Suscept ibility for Environmentally-Induced Diseases

University of California-DavisAlan R. Buckpit t

Species Differences in Naphthalene Toxicity:Implicat ions for Humans

University of IowaKeri Hornbuckle

Industrial Chemicals in Urban Environments: Airborne PCBs & their Sources

University of ArizonaRaina Maier

Phytostabilizat ion of Mine Tailings in Arid Environments: Plant Establishment and Tailings Characterizat ion

Dartmouth CollegeCelia Y Chen

Ecological Factors Controlling Metal Bioaccumulat ion & TrophicTransfer in Aquat ic Food Webs

Michigan State UniversityJames Tiedje

Using High Throughput DNA Sequencing to Better Characterize PCB, PAH, & Dioxin

Biodegradat ion Capacit ies in Environmental Matrices

For more information please contact Agency for Toxic Substances and Disease Registry

4770 Buford Hwy. NE, Chamblee, GA 30341 Telephone: 1-800-CDC-INFO (232-4636)/TTY: 1-888-232-6348E-mail: cdcinfo@cdc.gov Web: www.atsdr.cdc.gov

The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

NCEH/ATSDRLooks Forward To Meeting

More SRP Scient ists in

2011 !

Agency for Toxic Substances and Disease RegistryNational Center for Environmental Health