research today for the best research today … our crc hkl staffs are encouraged to contribute any...

RESEARCH TODAY FOR THE BEST HEALTHCARE OF TOMORROW

Research Today for the Better Healthcare of Tomorrow

IN THIS ISSUE

Words from editor

Page 2

Story behind a good

accomplishment

Page 3

Training and work-

shop

Page 4

Publication and

achievement

Page 7

Upcoming event/

Training / Workshop/

Research Day

1

WORDS FROM EDITOR

Assalamualaikum & Greetings to all the Readers

We meet again ! I hope everyone is in a good health. Time flies so fast as we have entering

the first quarter of 2018. CRC HKL e-newsletter starts our issue for this year by a sharing

session from Dr. Noor Ashani Md Yusoff, who has been nominated as Top 2 Recruiter in

Malaysia by PAREXEL in the study 223138 ; NOPRODPCR4001 - Prostate Cancer registry

study in Asia. Hit the target of 40% more patients recruited than other sites is not an easy

job. Let’s hear some words of encouragement from him which I think it could instill the

spirit to all of us to work towards clinical research in future.

Besides, we also would like to share about our annual event, the HKL Research Day 2017

which was held in last August 2017. It was a success to see the event went smooth with all

the positive feedback from the participants. Definitely, it would not be accomplished

without a strong support from all the HKL staffs.

In publication section, we also would like to take this platform to share with all of you the

list of research title that have been successfully published in various types of journal

nationally and internationally. Congratulation to all the hard work that every of you put in

making the publication a success although the process may not be straight forward. Let’s

strive for more publication for 2018.

Last but not least, I hope that you will enjoy reading this issue. All the readers out there

including our CRC HKL staffs are encouraged to contribute any research-related article in

our upcoming issue. I believe CRC HKL e-newsletter can continue to be a platform in

promoting research especially within our CRC and HKL family. See you again in our next

issue and happy reading. Take care.

Issue 4

STORY BEHIND A GOOD ACCOMPLISHMENT

Dr. Noor Ashani Md Yusoff is a Consultant Urologist in Department of Urology,

Hospital Kuala Lumpur since December 2009. Prior to this ,he also held the position Head of

Urology department in Hospital Pulau Pinang from 2003 until 2009. He graduated his Medical

degree (MBBS) from University of Malaya in 1994 and his Master of Surgery (General) from

Universiti Kebangsaan Malaysia (UKM) in 2002. Mr Ashani completed his fellowship in Malaysian Urological

Association in 2007 and subsequently received Malaysian Board of Urology Certificate (MBU cert) in 2008. His

journey didn’t stop there. In 2010, Mr Ashani gained his fellowship in Robotic Surgery (University of Yonsei, Korea)

and Fellowship Royal College of Surgeon (FRCS) (Urology) in 2014. With the working experience more than 15

years in his specialty, he took the great opportunity to involve in many medical research. Recently, CRC HKL has been informed by PAREXEL (one of the top pharmaceutical company which

sponsors a number of Industrial Sponsored Research in Malaysia) about the outstanding performance by Mr Ashani

in his study entitled “Prostate Cancer registry study in Asia”. We are gladly to share with all the readers that he has

been announced as Top 2 Recruiter in Malaysia through his study by hitting the target of 40% more patients

recruited than other sites. A big congratulations to you, Mr Ashani.

Therefore, CRC HKL took this opportunity to feature him in our e-newsletter. Lets hear the keys of

success and accomplishment from him.

Issue 4

Teamwork Makes The Dream Work !

How did you get started in your

research journey?

“As a medical doctor, doing research is

part of our duty. However, doing

research in the busy working schedule in

MOH especially HKL is not that easy.

Actually, this is my first official industrial

initiated research conducted in Hospital

Kuala Lumpur. The opportunity was

given to me by my HOD Dr. Murali

Sundram because I’m doing Robotic Radi-

cal prostatectomy for patient with pros-

tate cancer.”

Can you share your strategy in

being the top 2 recruiters in

Malaysia for this particular trial?

“The key factor to make a successful

research is a good and dedicated

team because I will not be able to be

at clinic all the time. To motivate my

entire team, all the financial benefit

will go directly to the recruiter (sub-

investigators or SI) not to me as the

principle investigator (PI).”

Any advice for upcoming and

budding researchers? “Be prepared to get involve in research.

Get your Good Clinical Practice

certificate as soon as possible. That is

the requirement.”

What is your motivation in doing

clinical research? “To build up the name of Hospital Kuala

Lumpur in research.”

How do you find time to juggle

between your busy clinical

schedule and research? “Good and dedicated team member

and also the help from CRC and

CRM.”

What are some of the changes

that you would like to see in

the research culture in HKL? “More conducive environment for

Principle Investigator (PI) like

research assistants.”

What are some of your interests

outside of work? “Reading book (leadership, motivational

and financial) and watching movies”

“The main challenger is to assemble a good team. With good and dedicated team, the process will be much easier” .

In your opinion, what is the main

challenge in recruiting patients? “The main challenger is to assemble a good

team. With good and dedicated team, the

process will be much easier especially this is

just a prospective observational study. It is

not difficult to convince the patient to be

recruited.”

Have you ever been in a study where

you failed to recruit patients? What

did you learn from that experience?

“This is my first industrial initiated study.”

TRAINING & WORKSHOP

Issue 4

Hospital Kuala Lumpur Research Day 2017 marked the second endeavor by Clinical research Centre Hospital Kuala

Lumpur, CRC HKL. It was held on 10th of August 2017 at Main Auditorium Hospital Kuala Lumpur and officiated by the previous

HKL Director, YBhg. Dato’ Dr. Zaininah Mohd Zain. The HKL Research Day had a very good attendance response, total

estimation around 350 delegates which came from our hospital staffs, National CRC and other hospitals CRC colleagues as well

as volunteers support from universities such as Universiti Kebangsaan Malaysia (UKM) and Universiti Kuala Lumpur (UniKL). We

were lucky to have Clinical Research Malaysia (CRM) and Honestbee to be our sponsor for the event.

Maintain the same theme as 1st HKL Research Day entitled

“Research Today for the Best Healthcare of Tomorrow”, today HKL is

the National Premier Hospital whereby multidisciplinary specialties are

situated to offer the best services in the country. HKL has transformed

from a purely clinical-base hospital to renowned training postgraduate

training center and also as one of the main important research hubs in

Malaysia such as Pediatric Institute, Institute Perubatan Respiratori

(IPR) and Institut Kajisaraf Tunku Abdul rahman (IKTAR), whereby

research is part of the job scope for the dedicated clinicians here.

Thus, there is a great number of research findings resulting in the

improvement of the clinical outcomes of our patients.

The plenary session entitled “Grooming Young Investigators” delivered by

Dr Mahadevan Deva Tata who is currently serves as General & Upper GI surgeon,

and Head of Clinical Research Centre at Hospital Tuanku Ja’afar, Seremban. He initiated ‘Project Joey Initiative’ in his hospital which aims to nurture young and

budding researchers to develop their skills in conducting research. The misconception prevails that research

is hard, with no tangible rewards, and in recognition of the need to hone a new

generation of researchers in HKL, he shared his thoughts and experiences in how

best to nurture new blood into the research field.

Hospital Kuala Lumpur Research Day 2017

Honestbee booth (One of the sponsor for the event)

All CRC HKL staffs

Dato’ Dr Zaininah was

giving her speech after the officiation

ceremony.

Dr Mahadevan was

giving his talk on “Grooming Young

Investigators”

Dato Dr Zaininah dropped by at CRC HKL booth in

Auditorium

List of lucky draw prizes of the day sponsored by Honestbee

CRM representative was giving the speech

The delegates for the event

Dr Salina, the Head of CRC HKL was giving

her opening speech

TRAINING & WORKSHOP

Issue 4

The research day event continued with a forum session

entitled “Nurturing Research in HKL - Are We Equipped and

Prepared” participated by experienced panels who tried to unravel

the potential of HKL, and what challenges might lie ahead in our

pursuit towards the seamless integration of research in the current

clinical practice. For this, we invited Dr. Akhmal Yusof (CEO of Clinical Research Malaysia, CRM), Prof Datuk Dr Adeeba

Kamarulzaman (Dean of Faculty of Medicine, University Malaya) and

Dr Ng Poh Yin (Consultant of O&G, HKL) to lead the hot one-hour

forum session.

T h e r e

were fifty posters

and five oral presentations were contested. All the presentations were judged

fairly by 6 experienced and dedicated judges. They split into 3 for Oral and 3

for Poster presentation. Dr Mahadevan Deva Tata, Prof Dr Syed Zulkifli Syed

Zakaria (Consultant of Neonatology, HUKM & Clinical Epidemiologist HUKM)

and Dr Ngu Lock Hock (Consultant In Clinical Genetics and Inherited

Metabolic Diseases, HKL) led the Oral presentation session. While Dr Nurain

Mohd Noor (Head of CRC Putrajaya), Dr Chern Phei Ming (Head of CRC

Hospital Rehabilitasi Cheras) and Dr Jamaiyah Haniff (Head of Malaysian

Health Performance Unit, MHPU) be the judge for the posters. We would

like to congratulate to all the winners with their great and fruitful

presentation.

Last but not least, CRC HKL would like to thank everyone who has tirelessly contributed towards making this event a

success. We hope that we continue to show our commitment in ensuring a flourishing research culture in HKL and pave a

distinctive path for our future generation. See you in the HKL Research Day 2018.

During the forum session in the afternoon. From left: Dr Updesh (Chaiperson), Prof Dr Adeeba, Dr Akhmal and Dr Ng

Poh Yin

Line of Oral presentation judges. From left: Prof Dr

Syed Zulkifli, Dr Ngu Lock Hock and Dr Mahadevan

TRAINING & WORKSHOP

Radiology Interdepartmental Basic Statistic Workshop, Date: 16/8/17, Venue: CawanganTeknologi

Maklumat (CTM), Level 7, SCACC HKL. No. of Participants: 20 participants

Good Clinical Practice Workshop (GCP) in Collaboration with Department of Oncology &

Radiotherapy, Date: 19-21/8/17, Venue: Faculty of Health Science, HUKM. No. of Participants: 37 participants

Introduction to Clinical Research Workshop, Date: 26- 28/9/17, Venue: HSU Meeting Room, MMA building.

No. of Participants: 20 participants

Manuscript Writing Workshop, Date: 4-5/10/17, Venue: HSU Meeting Room, MMA building. No. of

Participants: 20 participants

Issue 4

PUBLICATION & ACHIEVEMENTS

No Month/

Year Author Research Title Journal Dept.

1. Jan 2017 Cheah IG Targeted Oxygen in the Resuscitation of Preterm

Infants, a Randomized Clinical Trial Pediatrics Pediatric

2. March

2017

Joyce Pauline Joseph,

Suganthi Cinnasami, Md

Hanip Rafia

Somali Woman with Multiple Sclerosis, A Case

Report Neurology Asia Neurology

3. March

2017

Shanti Viswanathan ,

Norzaini Rose Mohd

Zain, Mohd Hanip Rafia

Neuroimaging Findings are Sensitive and Specific in

Diagnosis of Tuberculous Meningitis Neurology Asia

Neurology,

Radiology

4. April

2017

Tan Wee Yong, Md

Hanip Rafia

Experience of Setting Up Acute Thrombolysis

Service in a Public Hospital in a Developing Country,

Malaysia

Journal of Stroke

and

Cerebrovascular

Disease

Neurology

5. April

2017 Ghazali Ahmad

A Randomized Cross-Over Study Comparing the

Performance of HD IntegraTM Central Concentrate

System Versus Pre-produced Concentrate in

Hemodialysis

BMC Nephrology Nephrology

6. April

2017 Chee Kok Yoon

A Comparison a Clinical Characteristics of Older

Adults Treated with Antidepressants in General and Psychiatric Hospitals in Asia: Use of Antidepressant

in Asia

Psychogeriatrics

Journal Psychiatry

7. April

2017

Eni Juraida Abdul

Rahman

Whole-Exome Sequencing of ETV6/RUNX1 in Four

Childhood Acute Lymphoblastic Leukemia Cases

Asian Pacific

Journal of Cancer

Prevention

Pediatric

(Oncology)

8. April

2017 Tan Wee Yong

Global Mortality Variations in Patients with Heart

Failure: Result from the International Congestive

Heart Failure (INTER-CHF) Prospective Cohort

Study

Lancet Global

Health Neurology

9. May 2017

Subramaniam

Thanimalai, Jeyaindran

Sinnadurai

Cost-Effectiveness of Warfarin Medication Therapy

Adherence Clinic Versus Usual Medical Clinic at

Kuala Lumpur Hospital

Value in Health

Regional Issues Medical

10. May 2017 Chee Kok Yoon

A Case of TREM2 Mutation Presenting With

Features of Progressive Non-Fluent Aphasia and

Without Bone Involvement

Australian and

New Zealand

Journal of

Psychiatry

Psychiatry

11. May 2017

Kamalananthan

Palaniandy, Mohammad

Saffari Mohammad

Haspani, Norzaini Rose

Prediction of Histological Grade and Completeness

of Resection of Intracranial Meningiomas: Role of

Peritumoural Brain Edema

Malaysian Journal

of Medical Science

Neurosur-

gery,

Radiology

12. June

2017

Shanti Viswanathan,

Carol Lao, Suraya

Yusoff, Norzaini Rose

Mohd Zain

Spinal Cryptococcoma Mimicking Spinal Cord Tumor

Complicated by Cryptococcal Meningitis in an

Immunocompetent Patient

Journal of

Neurology &

Neurophysiology

Neurology,

Radiology

*Continuation from the last issue.

Issue 4

Issue 4


No Month/


13. July 2017

Noorasyikin Mohamed

Ariffin, Joyce Pauline

Joseph

A Rare Case Of Cavernous Sinus Syndrome in a

Patient with Tuberculous Meningitis

Journal of

Neurology &

Stroke

Neurology

14. July 2017

Salina Abdul Aziz, Norl-

iza Chemi, Abdul Razak

Othman, Nurzuriana

Md Zaki

The Economic Burden of Schizophrenia in Malaysia

Dove Press

Journal,

Neuropsychiatric

Disease &

Treatment

Psychiatry

15. July 2017 Ong Swee Gaik

Real‑World Clinical Experience Of Biological

Disease Modifying Anti‑Rheumatic Drugs In Malaysia

Rheumatoid Arthritis Patients

Rheumatology

International Medical

16. July 2017 Mohd Fadzli Mohamad

Isa

Directly Observed Therapy for Clozapine with

Concomitant Methadone Prescription: A Method for

Improving Adherence and Outcome

BMJ Case Reports

2017 Psychiatry

17. July 2017

Hiew FL, Ramlan R,

Viswanathan S, Puvana-

rajah S.

Guillain-Barré Syndrome, Variants & Forms Fruste:

Reclassification with New Criteria.

Clinical Neurology

and Neurosurgery Neurology

18. July 2017 Viswanathan S, Wong

LC.

A Curious Case of Neuromyelitis Optica Spectrum

Disorder Co-existing with Idiopathic Intracranial

Hypertension.

Journal of Clinical

Neuroscience Neurology

19. July 2017 Shanti Viswanathan

Private Health Payers, Universal Health Coverage

and Access to High-Cost Medicines for the

Management of Multiple Sclerosis in Malaysia

BMJ Case Report Neurology

20. August

2017

B.C.Peng,S.Y.Yee,MZA

bdul

Wahab,R.Yahya,S.Bavan

andan,R.Visvanathan,G.

Ahmad

Early and Late Nephrology Referral Among Patients

with Acute Kidney Injury in a Tertiary Hospital

Kidney

International

Reports

Nephrology

21. August

2017 R.Visvanathan

A Prospective Multicenter, Observational Study to

Determine the Incidence and Outcome of Acute

Kidney Injury Among Hospitalized Patients in

Malaysia,

Kidney

International

Reports

Nephrology

22. August

2017

S.Y.Yee,MZAbdul

Wahab,

R.Visvanathan,R.Yahya,

S.Bavanandan,G.Ahmad

Incidence and Outcome of Patients with Acute

Kidney Injury in Hospital Kuala Lumpur

Kidney

International

Reports

Nephrology

23. August

2017

Dr Kee Hoe Lai,

S.Y.Yee, MZAbdul

Wahab, R.Visvanathan,

R.Yahya, S.Bavanandan,

G.Ahmad

Renal Replacement Therapy in Acute Kidney Injury

in a Tertiary Hospital

Kidney

International

Reports

Nephrology

24. August

2017 Rosminah M. Kassim

Lung Disease Stratification using Amalgamation of

Riesz and Gabor Transforms in Machine Learning

Framework

Computers in

Biology and

Medicine

Radiology

25. August

2017

Jelinar Mohamed-Noor,

Dhaniah Abd-Salam

Refractive Errors And Biometry Of Primary

Angle-Closure Disease In A Mixed Malaysian

Population

International

Journal of

Ophthalmology

Ophthalmolo-

gy

CRC HKL E-Newsletter


No Month/


26. August

2017

Ngu Lock Hock,

Keng Wee Teik

Molecular Analysis of Fragile X Syndrome (FXS)

among Malaysian Patients with Developmental

Disability

Malaysian Journal

Pathology 2017 Genetic

27. August

2017 Yap Y.C., S. Sidhu

Epidemiology & Outcome of Acute Kidney

Injury in Pediatric Patients Treated With Renal

Replacement Therapy in Malaysia—A 7 Years

Multicenter Review

Kidney

International

Report

Pediatric

28. August

2017 Yap Y.C., S. Sidhu

Peritoneal Dialysis First in Severe Acute Kidney

Injury in Children

Kidney

International Pediatric

29. August

2017

Chee Kok Yoon, Yee

OK, Norzaini Rose

Mohd Zain

A Case of Early-onset Familial Alzheimer's

Disease with Both APP and Novel PSEN2

Mutations Presenting with Non-amnestic

Features.

Australian & New

Zealand Journal of

Psychiatry

Psychiatry,

Radiology

30. August

2017

Rosnawati Yahya,

Sunita Bavanandan,

Dato' Ghazali Ahmad

Early & Late Nephrology Referral Among

Patients With Acute Kidney Injury in a Tertiary

Hospital

Kidney

International

Report

Nephrology

21. September

2017

Ngu Lock Hock,

Winnie Ong Peitee,

Huey Yin Leong, Hui

Bein Chew

Case Report of Treatment Experience with

Idursulfase Beta (Hunterase) in an Adolescent

Patient with MPS II

Molecular Genetics

and Metabolism

Reports

Genetics

32. September

2017 Mahmood MS

Oryong 501 Sinking Incident in the Bering

Sea-International DVI Cooperation in the Asia

Pacific.

Forensic Science

International Forensic

33. September

2017

Mohd Noor MS,

Khoo LS, Zamaliana

Alias WZ, Hasmi AH,

Mahmood MS.

The Clandestine Multiple Graves in Malaysia:

The First Mass Identification Operation of

Human Skeletal Remains.

Forensic Science


34. September

2017 Ng Poh Nee

Serratus Plane Block as a Primary Analgesic

Technique for OFF-Midline Upper abdominal

surgeries: A Case Series in Open

Nephrectomies

British Journal of

Anesthesia Anesthesiology

35. October

2017 Sunita Bavanandan

Dialysis Provision and Implications of Health

Economics on Peritoneal Dialysis Utilization: A

Review from a Malaysian Perspective

International

Journal of

Nephrology

Nephrology

36. October

2017 Alzamani Idrose

Challenges of Communication System During

Emergency Disaster Response in Malaysia: A

Review

Journal of

Fundamental and

Applied Sciences

A& E

37. October

2017 Alzamani Idrose

Reliable Monitoring of Oxygen Saturation Via

Pulse Oximetry: Which Site to Choose

Journal of

Fundamental and

Applied Sciences

A& E

38. November

2017 Salina Abdul Aziz

Evaluation of Methadone Treatment in Malaysia:

Findings from the Malaysian Methadone

Treatment Outcome Study (MyTOS)

Substance Use &

Misuse Psychiatry

Issue 4

Issue 4

No Month/


39. November

2017

Huey Yin Leong, Ngu

Lock Hock

Fructose-1,6-Bisphosphatase Deficiency As A

Cause Of Recurrent Hypoglycemia And Metabolic

Acidosis: Clinical And Molecular Findings In

Pediatric &

Neonatology Genetic

40. November

2017

Mahmood MS, Abdullah

N

Manifestation of Coronary Atherosclerosis in Klang

Valley, Malaysia: An Autopsy Study.

Journal of

Atherosclerosis

and Thrombosis

Forensic

41. November

2017 Suganthy Robinson

The Utilization of Cutaneous Laser Therapy at the

Department of Dermatology, Hospital Kuala

Lumpur: A 5 Year Review

Malaysian Journal

of Dermatology Dermatology

42. November

2017 Chng Kay Ly

Death of Two Military Pilots in Hawk-108 crash -

A Case Report

Forensic Science


43. November

2017 Loo Chai Har From Red Herring to Malignancy

Malaysian Journal

of Dermatology Dermatology

44. December

2017

Izzaty Dalawi, Tang Min

Moon, Asmah Johar

Drug Resistance Pattern of Mycobacterium leprae

from Mouse Footpad Cultivation between 1997-

2013 in Malaysia

Lepra Review Dermatology/

CRC HKL

45. December

2017 Ngu Lock Hock

Progressive Deafness‐dystonia due to SERAC1

Mutations – A study of 67 cases

Annals of

Neurology Genetics

46. December

2017 Chee Kok Yoon

Concurrent benzodiazepine use in older adults

treated with antidepressants in Asia

International

Psychogeriatrics Psychiatry


Total number of Publications in 2017 captured: 70

14

109

76 6

5 5

3 3 32 2

1 1 10 0 0 0

0

2

4

6

8

10

12

14

16

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Me

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Otorhin…

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No. of Publication HKL Jan-Dec

2017

UPCOMING CRC HKL EVENTS

HKL RESEARCH DAY 2018

Issue 4

April 2018

1. Good Clinical Practice Workshop

Date: 23-25 April 2018

Venue: Adamson Hotel, Kampung Baru Kuala Lumpur

Fees: RM 450

May 2018

1. Proposal Writing Workshop

Date: 2 May 2018

July 2018

1. Research Methodology Workshop

Date: 17-19 July 2018

August 2018

1. Data Management and Statistics Workshop

Date: 7-9 August 2018

2. HKL Research Day 2018

Date: 30 August 2018

Venue: Main Auditorium Hospital Kuala Lumpur

Fees: Free of charge

September 2018

1. Good Clinical Practice Workshop

Date: 4-6 September 2018

WELCOME TO OUR NEW STAFFS

Dr. Mohd Azizi Shaukani, Medical Officer UD 48 Has been working with CRC HKL since February 2017

Will continue his career path in Department of Radiology, Hospital Kuala Lumpur

All the best in your future undertakings.

FAREWELL: TRANSFER OF OUR STAFFS

Dr. Noor Hidayu Binti Wahab, Medical Officer UD 44 She has been working with CRC HKL since November 2017

Previously, she was from Kinsukuroi Unit, Department of Psychiatry, Hospital

Kuala Lumpur Welcome aboard! Looking forward for your new ideas and insights that will

contribute to our unit.

Issue 4

EDITORIAL TEAM

ADVISOR

DR. HJH SALINA ABDUL AZIZ

EDITOR-IN-CHIEF

DR IZZATY DALAWI

EDITORIAL COMMITTEE

DR NOOR HIDAYU WAHAB

DR DURATUL’AIN

DR NURUL ASYIQIN AZIZ

DR LEE JEN VEN

CLINICAL RESEARCH CENTRE,

HOSPITAL KUALA LUMPUR,

LEVEL 7, SPECIALIST COMPLEX &

AMBULATORY CARE CENTRE (SCACC),

JALAN PAHANG, 50586 KUALA LUMPUR.

PHONE NO. : 03-26155555 EXT 1782/1783

FAX : 03- 2604 0818 You’re welcome to contribute (News, Events,

Publications, Article of interest, etc.) to us by email:- [email protected],

[email protected] or

[email protected]

CONTACT US

mailto:[email protected]

research today for the best research today … our crc hkl staffs are encouraged to contribute any...

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