research methodology
TRANSCRIPT
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RESEARCH METHODOLOGY, BIOSTATISTICS &
DISSERTATION WRITING workshop at
Regional Centre Abbottabad14 – 17 Sep, 2013
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WHAT IS RESEARCH?
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Origin of the Word “Research”
From the French word "recherche" which means to travel through or survey
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Research is
A Process of Systematic,Scientific Data
Collection
Analysis &
Interpretation
So as to find Solutions to a problem.
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Types of Research
Qualitative
Quantitative
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Research - Types
Qua L itative
Descriptive
Numbers not the primary focus
Interpretive, ethnographic, naturalistic
04/11/2023
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04/11/20237
Steps of Research
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Steps in Designing & Conducting Research
Matching the Research Design to research objectives
Thinking about topic formulating research question/ objective
Defining and clarifying the research Variables/ Analysis plan
Drawing the Sample
Developing the tools & defining the methods of data collection
Monitoring and Carrying out the research
Preparing the Data for Analysis
Analyzing Data
Writing the Research Report
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Title of The Study
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Title
Title should be short, concise and informative• Crispy, that catches the eye• Accurate, that tells what the paper is about and the
problem studied• Method by which problem studied, if possible• Should excite rather than stifle interest• Title should almost never contain abbreviations,
chemical formulas, proprietary names and the like• It would neither be in negative or interrogative form
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The first 7 words are redundant. It is clear that it is a research study so words like “an enquiry entitled.” or “A study to--------”are SPACE TAKERS.
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Examples
1. The scheme for the investigation into the basic factors responsible for the development of resistance in malaria patients under chloroquin therapy.”
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2. “ Research in Experimental Surgery”
too vague and gives no information on the line of work.
3. “Neuro chemical studies on experimentally induced convulsions in relation to normal and anaesthetised animals and survey of epileptic patients and certain neuro chemical studies on the cerebrospinal fluid of preclassified epileptic patients.”
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4. “Further studies on Eczema and Dermatitis”
not better than “Eczema and Dermatitis”
5. “Assessment of the susceptibility of mosquitoes of public health importance to insecticides and investigation of other related problems.”
The last 6 words do not add any information.
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6. “Investigation of etiology of urolithiasis with special reference to malnutrition and dietary factors etc.”
‘ etc’. Should never be in the title . It has no meaning . The title could have been
“Role of mal-nutrition and dietary factors in the etiology of urolithiasis.”
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7. “Study of management of extremely low birth weight neonates at Sheikh Zayed Hospital Lahore for evaluating the problem in Pakistan”
A study conducted at Sheikh Zayed Hospital cannot be generalized for Pakistan
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Selecting a Research Topic
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Criteria for Selecting a Research Topic
Relevance Innovation Feasibility Acceptability Cost-effectiveness Ethical consideration
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CRITERIA FOR SELECTION
Proposed Topic
Re
leva
nc
e
Inn
ov
atio
n
Fe
as
ibility
Ac
ce
pta
bility
Co
st
Effe
ctiv
en
es
s
Eth
ica
l TOTAL SCORE
How big is the problem?How important is it to look for relevant solutions to it ?
Are solutions to it available, if so how effective have they been proved? ?Is this the problem of importance in our local set up?
Priority Ratings for Research Proposals
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CRITERIA FOR SELECTION
Proposed Topic
Re
leva
nc
e
Inn
ov
atio
n
Fe
as
ibility
Ac
ce
pta
bility
Co
st
Effe
ctiv
en
es
s
Eth
ica
l TOTAL SCORE
In case the topic has been researchedwhat new are you
looking at
Priority Ratings for Research Proposals
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CRITERIA FOR SELECTION
Proposed Topic
Re
leva
nc
e
Inn
ov
atio
n
Fe
as
ibility
Ac
ce
pta
bility
Co
st
Effe
ctiv
en
es
s
Eth
ica
l TOTAL SCORE
Consider the resources that are required to carry
out the project
Priority Ratings for Research Proposals
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CRITERIA FOR SELECTION
Proposed Topic
Re
leva
nc
e
Inn
ov
atio
n
Fe
as
ibility
Ac
ce
pta
bility
Co
st
Effe
ctiv
en
es
s
Eth
ica
l TOTAL SCORE
research a topic which has the interest and
support of the authorities
Priority Ratings for Research Proposals
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CRITERIA FOR SELECTION
Proposed Topic
Re
leva
nc
e
Inn
ov
atio
n
Fe
as
ibility
Ac
ce
pta
bility
Co
st
Effe
ctiv
en
es
s
Eth
ica
l TOTAL SCORE
Whether the resources of time,
money and manpower being invested in the study are worthwhile
Priority Ratings for Research Proposals
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CRITERIA FOR SELECTION
Proposed Topic
Re
leva
nc
e
Inn
ov
atio
n
Fe
as
ibility
Ac
ce
pta
bility
Co
st
Effe
ctiv
en
es
s
Eth
ica
l TOTAL SCORE
Priority Ratings for Research Proposals
• Cultural sensitivity must be given careful consideration.
• Informed consent ensured.
• Will treatment be given to individuals identified during study who require treatment?
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Medical Ethics: Four Principles Respect for autonomy
informed consentcommunicationconfidentiality
Beneficence (Provide the benefits) Non-maleficence (Do no harm) Justice
fair distribution respect for people's rights respect for moral values
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Ethical Issues
Informed Consent. Respect for privacy. Confidentiality and anonymity of data. What is permissible to ask? No harm to researchers or subjects. No deceit or lying in the course of research. Consequences of publication.
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Proposed Topics
CRITERIA FOR SELECTION
Relevance
Innovation
Feasibility
Acceptability
Cost Effectiveness
Ethical Consideration
Total Score
Complications of AIDS 1 3 1 1 1 1 08 Smoking & Birth Weight 2 2 2 2 3 3 14
Lead in Blood 3 3 3 3 3 3 18
………….
Priority Ratings for Research Proposals
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LiteratureSearch
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Allows one to search in a purposeful and
systematic manner, through a range of
literature or information relevant to one’s
particular field, and to hone in on material
relevant to ones interest and objectives.
What is Literature Search?
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Why do Literature Search
To keep up with the latest developments in your field.
To learn more about some topic. To document important facts and ideas you wish
to research in light of previous work done on it. To understand your data in the context of what is
already known. To provide your readers with sources they can
consult on their own.
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Means of Literature Search – Internet
Access to a massive pool of information related to
biomedical and clinical source.
Can link with library catalogues, online databases, like
MEDLINE and direct access to ever increasing number of
biomedical journals.
Retrieval of data from a range of organizations
universities, research establishments and hospitals.
Many services are available free of charge.
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Search Strategy on Internet
Summarize your topic in one or two sentences.
Identify the unique ideas or concept associated
with your topic.
Choose appropriate keywords for each concept.
Establish the relationship between each keyword
and concept.
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Example Pub Med Sources
PubMed is derived from two words, Publications,
and Medical.
It is a project of the National Institute of Health,
National Library of Medicine.
Available on the internet, there are thousands
medical journals on this list.
It searches for you from millions of papers.
For more details of PubMed, you may visit.
http://www.ncbi.nlm.nih.gov/PubMed/
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Searching Online Medical Resources
For General Info: www.google.com.pk/:For Research Articles Only: http://scholar.google.com.pk/For translating text from any language:http://translate.google.com.pk/For Google Images: http://www.google.com.pk/imghp?hl=en&tab=iiTo get answers for your questions: www.ask.com/Pakistani local Journals: www.pakmedinet.com/:
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Free Medical Journals: websites
http://www.lau.edu.lb/libraries/research-tools/free-journals-list.php.www.freemedicaljournals.com/http://highwire.stanford.edu/lists/freeart.dtlDOAJ(Directory of open access journals): http://www.doaj.org/MedIND (http://medind.nic.in/)
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Use of the Internet
General Purpose Search Engines Yahoo (www.yahoo.com) Altavista (www.altavista.com) MSN (www.msn.com) Google (www.google.com) Copernicus (www.copernicus.com) Metacrawler (www.metacrawler.com)
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Use of the Internet
Medical Search Engines MedHunt (www.medhunt.com) MedNets (www.mednets.com) HealthAtoZ (www.healthatoz.com) DoctorNet (www.doctornet.com) MedConnect (www.medconnect.com) OMNI (www.omni.ac.uk) and many more…. Get a complete list by typing
“medical search engines” in any good browser.
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Use of the Internet
Some Good Medical Websites: www.medscape.com : an excellent site for medical
professionals. Free registration, access to specialty and subspecialty pages, full-text articles and the latest medical news and events. Includes CME content.
www.who.int : the website of the WHO. Provides the latest activity of the WHO, annual reports, bulletins,monographs, research funding reports and forms, global vital statistics and trends.
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Use of the Internet
www.cdc.gov : the official website of the Centers for Disease Control (CDC) in Atlanta, Georgia, USA. It provides global information on a variety of
diseases, chiefly infectious diseases, epidemiology and disease control.
The statistical software Epi Info is available for download from this site.
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Use of the Internet
Websites for free full-text articles: www.medscape.com : free full-text retrieval for
members, as already mentioned. www.freemedicaljournals.com : a major new source of
journals in almost all specialties, that allow free full text article retrieval.
Journal Websites: www.thelancet.com, www.bmj.com, www.nejm.org, : allow free full-text retrieval of journal articles through their own search engine as well as an archival catalog.
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Use Internet wisely www.mzb.lv : website of the Medical Research
Library of Latvia. Has an English version of its browser; lists specialty and subject-wise journals and websites for free full-text retrieval.
Both www.who.int and www.cdc.gov allow full-text article retrieval freely.
Many other sites, particularly online journal sites, allow full-text article retrieval after payment or for journal subscribers.
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Some useful sites
Medline www.ncbi.nlm.nih.gov/pubmed/ NIH/NLM www.nlm.nih. www.pubmed.org www.pubmedcentral.nih.gov/ www.gfmer.ch or www.gfmer.ch/medical_journals/free_medical.p
hp (a German foundation for medical research and education. First go on it, select topic than click on pub med free full text at the top and get the search)
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List of publishers websites
J-Gate www.openj-gate.org www.highwire.stanford.edu/list/freeart.dtl
(1 million full text articles available here) www.healthnet.org www.biomedcentral.com www.plos.org
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Boolean Search
Use AND to narrow search and retrieve records containing all of the words it separates.
Use OR to broaden search and retrieve records containing any of the words it separates.
Use NOT to narrow search and retrieve records that do not contain the term following it.
Use ( ) to select a phrase or groups of words Phrase - (participatory action research) Groups of words – (housing or homelessness) AND
(budget or funding)
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Scientific Paper
Organisation Title Authors Abstract______________________________________________________________________________________
Introduction Materials & methods Results Discussion References
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ResearchObjective
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• To show the extent and the expected outcome of the study
• To begin with a leading statement followed by the objectives written in point forms
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Research Objectives
An objective is an intent of what the
researcher wants to do stated in clear
measurable terms.”
summarizes what is to be achieved by
the study.
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Importance of Research Objectives
1. Brings focus to the study.
2. Avoids collection of unnecessary data.
3. Determines an appropriate study design.
4. Helps determine analysis plan.
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A Good Objective should be SMART…...
S PECIFIC
M EASURABLE
A CHIEVABLE
R ELEVANT
T IME-BOUND
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A Good Objective ensures that:
What is to be measured is clearly stated, be it a measure of frequency, or Association in the
population of interest.
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A good objective ensures that:
What is to be measured is clearly stated
be it:o A frequency measure
o Association between two variables
o Difference between two groups
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ExamplesObjectives:
1)To determine the frequency of anemia in pregnant
women visiting Tertiary care facilities of Sindh.
2) To determine association between maternal
smoking and LBW.
3) To compare the effectiveness of dressing A vs.
dressing B in patients presenting with infected
wounds of the foot.
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Operational Definition
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Operational Definitions
Is the definition of the exposure and outcome variables of interest in context to objective in a particular study and their means of measurement/determination.
Examples: Anemia Effectiveness PPH Wound healing
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The objectives should be followed by some ‘operational definitions’.
These should be picked from the title and objectives.
Include defining your meanings to these terms as you plan to use in your study. Terms like ‘efficacy’, ‘association’, ‘correlation’, ‘complications’ ‘satisfaction’ may need to be defined.
If drugs are to be used, their route, dose, and duration should be listed.
Operational Definitions
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Operational Definitions
Definitions of operational terms used under the conditions of your research study.
Examples: Define anaemia in a study on anaemic patients: < 10 g/dl or < 12 g/dl. Define SBP in a study on hypertensive patients:
> 140 mm Hg or age adjusted values.