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    Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

    Human Anatomy & Physiology, Sixth Edition

    Elaine . !arieb

    PowerPoint® Lecture Slides prepared by Vince Austin, University of Kentucky

    Sistem Reproduksi

    Wanita

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    Anatomi Reproduksi Wanita

    "#arium adl organ reprodu$si utama %anita

    !&buat gamet  'o#a(

    !&se$resi$an hormone $elamin   'estrogen )

     progesterone(

    "rgan a$sesoris* du$tus t&ms$ tuba uterin, uterus,

    dan #agina +enitalia internal o#arium ) du$tus internal

    +enitalia e$sternal organ2 $elamin e-ternal

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    Anatomi Reproduksi Wanita

    /igure 2.11

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    Ovarium

    Pasangan organ yg ada di tiap sisi uterus ygdipegang oleh bbrp ligaments

    "#arian jang$ar o#ary leta$nya medial thd uterus

    uspensory jang$ar o#ary leta$nya lateral thd

    dinding pel#is 'panggul(

    !eso#arium m&gantung$an o#arium di tengahnya 3igament luas tda ligament suspensory dan

    meso#arium

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    Ovarium

    /igure 2.14a

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    Ovarium

    uplai darah arteri o#arian ) cabang o#arian dari arteri

    uterine

    !ere$a di$elilingi oleh tunica albuginea 6ibrous, yg ditutup

    oleh selapis sel epithel yang disebut epitel germinal

    !enempel dlm $orte$s o#ary adl 6oli$el o#arian

    7iap 6ollicle tdd satu telur yg blm masa$ 'immature( yg

    disebut oocyte

    el2 di se$itar oocyte disebut*

    el2 6ollicle 'satu sel b&lapis tebal(

    el2 granulosa 'di mana t&dpt lbh dr 1 lapis(

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    Ovarium

    6oli$el primordial satu lapis sel 6oli$el mirip

    s$uamos yg mengelilingi oocyte

    6oli$el primer dua 8 lebih lapis sel2 granulosacuboid menutupi oocyte

    6oli$el se$under mempunyai ruang yang berisi

    cairan antara sel2 granulosa yang menyatu untu$membentu$ central antrum

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    Ovarium

    /ollicle +raa6ian 6oli$el se$under pd $ebanya$an

    tahap matur yg m&beng$a$ dari permu$aan o#arium

    "#ulasi pengeluaran oocyte dari pematangan

    6oli$el

    Corpus luteum 6oli$el yg ruptur setelah o#ulasi

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    Ovarium

    /igure 2.12

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    Tube Uterina (Tuba allopii! dan Ovidu"ts

    !enerima oocyte yg telah mengalami o#ulasi danmemberi$an tempat untu$ 6ertilisasi 'pembuahan(

    Berjalan $e regio superolateral uterus #ia isthmus

    !elebar secara distal di se$itar o#arium membentu$

    ampulla

    ;mpulla bera$hir dg bentu$ corong. In6undibulum*ujung dari tuba dg umbai

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    Tube Uterina

    7uba uterina td$ punya $onta$ dg o#arium dan

    oocyte yg telah o#ulasi dilempar di rongga peritoneum

    =enyut cilia pada 6imbriae mencipta$an arus untu$

    memba%a oocyte $e dalam tuba uterine "ocyte diba%a $e arah uterus oleh peristalti$ dan

    $erja ciliary

    el2 noncilia menjaga oocyte dan sperma cu$up gi>idan lembab

    !esosalpin- peritoneum #isceral yg menopang

    tuba uterina

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    Uterus

    "rgan berongga dg dinding tebal t&leta$ dlm pel#is

    anterior thd rectum ) posterosuperior thd $andung

    $emih

    Body porsi besar dari uterus

    /undus regio yg m&bulat superior thd pintu masu$

    tuba uterine

    Isthmus regio yg menyempit antara body ) cer#i-

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    1

    Uterus

    Cer#i- 'leher rahim( leher sempit yg tdpt dlm

    in6erior #agina

    Cer#ical canal rongga cer#i- yg menghubung$an

    dengan*

    ?agina #ia os e-ternal

    Badan uterus #ia os internal

    @elenjar ser#i$s mense$resi mucus yg menutupi os

    e-ternal dan menghalangi sperma masu$ $ecuali

    selama pertengahan si$lus

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    #upports o$ the Uterus

    !esometrium portion o6 the broad ligament that

    supports the uterus laterally

    3ateral cer#ical ligaments e-tend 6rom the cer#i-

    and superior part o6 the #agina to the lateral %alls o6the pel#is

    Aterosacral ligaments paired ligaments that secure

    the uterus to the sacrum

    ound ligaments bind the anterior %all to the labia

    majora

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    Peritoneal Pou"hes

    e#eral cul

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    %inding uterus

    7erdiri dari lapisan

    Perimetrium outermost serous layer the #isceral

     peritoneum

    !yometrium middle layer interlacing layers o6

    smooth muscle

    Endometrium mucosal lining o6 the uterine ca#ity

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    Uterine Wall

    /igure 2.1b

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    ndometrium

    !empunyai sejumlah $elenjar uterus yg berubah

     panjangnya seperti berubahnya $etebalan endometrial

    tratum 6ungsionalis*

    !engalami perubahan si$lus dlm merespon thd hormon2

     o#arium

    =itumpah$an selama menstruasi

    tratum basalis*

    !embentu$ 6ungsionalis baru setelah menstruasi bera$hir 

    7ida$ merespon thd hormon2 o#arium

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    #upply Pembuluh %arah Uterus

    ;rteries uterine arise 6rom the internal iliacs,

    ascend the sides o6 the uterus and send branches intothe uterine %all

    ;rcuate arteries branches o6 the uterine arteries in

    the myometrium that gi#e rise to radial branches

    adial branches descend into the endometrium and

    gi#e o66*

    piral arteries to the stratum 6unctionalis

    traight arteries to the stratum basalis

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    #uplai Pembuluh %arah Uterine

    =egeneration and regeneration arteri spiral

    menyebab$an 6ungsionalis ditumpah$an selamamenstruasi

    ?ena endometrium berdinding tipis dengan

     pelebaran sinusoid

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    'agina

    aluran berdinding tipis yg terleta$ antara $andung$emih dan re$tum, memanjang dari cer#i- bagian

    luar tubuh

    Arethra dile$at$an pd dinding anterior

    !emberi$an jalan untu$ persalinan, aliran

    menstruasi, dan merupa$an organ senggama

    !u$osa de$at ori6isium #agina membentu$ suatu

    se$at yg tida$ sempurna yg disebut hymen

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    ternal )enitalia* 'ulva (Pudendum!

    7erleta$ di bag luar #agina, termasu$ mons pubis,labia, clitoris, dan #estibular 

    !ons pubis bundar, area berlema$ di atas sim6isis

     pubis

    3abia majora memanjang, ditutupi rambut, lipatan

    $ulit berlema$ homologous thd s$rotum la$i

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    ternal )enitalia* 'ulva (Pudendum!

    @elenjar #estibular yg lebih besar 

    @elenjar sebesar $acang polong yg mengapit#agina

    Domologous to thd $elenjar bulbourethral 'pria(

    !enjaga #estibule lembab dan melumasi

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    ternal )enitalia* 'ulva (Pudendum!

    Clitoris 'homologous to the penis(

    Erectile tissue hooded by the prepuce

    7he e-posed portion is called the glans

    Perineum

    =iamond

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    +ammary )lands

    !odi6i$asi dari $elenjar $eringat yang terdiri dari 1<

    2 lobus yang menyebar di se$itar dan membu$a pada puting

    ;reola pigmentasi $ulit di se$itar puting

    uspensory ligaments attach the breast to underlying

    muscle 6ascia

    3obus2 berisi glandular al#eoli yg m&produ$si susu

     pada %anita menyusui

    Campuran $elenjar al#eolar menyalur$an susu $e

    du$tus lacti6erous, yg membu$a $e bag luar 

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    #tru"ture o$ a"tating +ammary )lands

    /igure 2.1

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    -reast .an"er 

    Asually arises 6rom the epithelial cells o6 the ducts

    is$ 6actors include*

    Early onset o6 menses or late menopause

     o pregnancies or the 6irst pregnancy late in li6e Pre#ious history o6 breast cancer or 6amily history o6 breast

    cancer 

    Dereditary 6actors including mutations to the genes BC;1and BC;2

    0 o6 %omen %ith breast cancer ha#e no $no%n ris$6actors

    .

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    -reast .an"er* %ete"tion and Treatment

    Early detection is by sel6

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    Oogenesis

    O i P b t

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    Oogenesis* Puberty

    ;t puberty, one acti#ated primary oocyte produces t%ohaploid cells

    7he 6irst polar body

    7he secondary oocyte

    7he secondary oocyte arrests in metaphase II and is o#ulated

    I6 penetrated by sperm the second oocyte completes meiosisII, yielding*

    "ne large o#um 'the 6unctional gamete(

    ; tiny second polar body

    t $ O i

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    vents o$ Oogenesis

    /igure 2.1:

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    $ lik l

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    ase $olikuler 

    /oli$el primordial, diarah$an oleh oocyte, menjadi a6oli$el primer 

    /oli$el primer menjadi 6oli$el se$under 

    7e$a 6olliculi dan sel

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    ase $olikuler 

    /oli$el se$under menjadi 6oli$el #esicular 

    ;ntrum melebar dan m&isolasi oosit dan corona

    radiata /oli$el #esicular membeng$a$ dari permu$aan luar

    o#arium

    "osit primer meleng$api meiosis I, dan tahap yang

    diatur untu$ o#ulasi

    O i . l

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    Ovarian .y"le

    /igure 2.20

    O lasi

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    Ovulasi

    "#ulasi terjadi $eti$a dinding o#arium ruptur dan

    mengeluar$an oosit se$under

    !ittelschmer> nyeri tusu$ $adang terasa saat

    o#ulasi

    1

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    ase uteal

    etelah o#ulasi, 6oli$el yg ruptur collaps '$empes(,

    sel2 granulosa cells membesar, dan bersama sel2the$a internal, membentu$ corpus luteum

    @orpus luteum mense$resi$an progesterone and

    estrogen Hi$a $ehamilan tida$ terjadi, corpus luteum

    mengalami degenerasi dlm 10 hari, meninggal$ans$ar 'corpus albicans(

    Hi$a $ehamilan terjadi, corpus luteum m&produ$sihormon sampai plasenta mengambil alih peran tsb'pad se$itar bulan(

    +enetapkan #iklus Ovarium

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    +enetapkan #iklus Ovarium

    elama masa $ana$ 2, o#arium tumbuh dan

    mense$resi$an sejumlah $ecil estrogen yg

    menghambat lepasnya +nD hypothalami$ 

    !enjelang pubertas, +nD dilepas$an /D dan 3D

    dilepas$an oleh pituitary, yg be$erja pd o#arium

    Peristi%a ini berlanjut sampai suatu pola si$lusde%asa dicapai dan menarche terjadi

    /nteraksi Hormonal #elama #iklus Ovarium

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    /nteraksi Hormonal #elama #iklus Ovarium

    Dari 1 +nD merangsang lepasnya /D dan 3D

    /D dan 3D merangsang pertumbuhan ) pematangan 6oli$el,dan estrogen $adar rendah dilepas$an

    !ening$atnya $adar estrogen*

    !enghambat lepasnya /D dan 3D

    !emacu pituitary untu$ mensintesa dan mengumpul$an

    gonadotropin2 ini

    @adar estrogen mening$at dan tingginya $adar estrogen

    memili$i e6e$ umpan bali$ positi6 pituitary, menyebab$anhenta$an mendada$ dari 3D

    /nteraksi Hormonal #elama #iklus Ovarium

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    /nteraksi Hormonal #elama #iklus Ovarium

    3D merangsang oocyte primer untu$

    menyempurna$an meiosis I, dan oocyte se$under

    melanjut$an $e metaphase II

    Dari $e 14 3D mencetus$an o#ulation

    3D mentrans6ormasi 'm&ubah bentu$( 6oli$el yg

    telah ruptur menjadi corpus luteum, yg m&produ$siinhibin, progesterone, dan estrogen

    /nteraksi Hormonal #elama #iklus Ovarium

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    /nteraksi Hormonal #elama #iklus Ovarium

    Dormon2 ini menutup /D dan 3D lepas dan

    menurun$an 3D di a$hir a$ti#itas luteal

    Dari $e 25

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    eedba"k +e"hanisms in Ovarian un"tion

    /igure 2.21

    #iklus Uterina (+enstrual!

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    #iklus Uterina (+enstrual!

    ang$aian si$lus perubahan yang dialami

    endometrium tiap bulan dalam merespon hormon

    o#arian dalam darah

    Dari 1

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    +enses

    Hi$a 6ertilisasi td$ tjd, $adar progesterone turun,

    menghilang$an du$ungan hormonal endometrium

    ;rteri spiral $a$u dan spasme dan sel2 endometrial

    mulai mati

    3apisan 6ungsional mulai mencerna dirinya sendiri

    ;rteri spiral mengerut pd satu %a$tu $emudian tiba2 

    rile$s ) membu$a lebar 

    =erasnya 6ragmen2 darah melemah$an bantalan

    $apiler dan lapisan 6ungsional mengelupas

    )onadotropins Hormones and the Ovarian and

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    45/igure 2.22a, b

    )onadotropins, Hormones, and the Ovarian and

    Uterine .y"les

    )onadotropins Hormones and the Ovarian and

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    4/igure 2.22c, d

    )onadotropins, Hormones, and the Ovarian and

    Uterine .y"les

    $ek0 trauterine strogens dan Progesterone

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    @adar estrogen mening$at selama pubertas

    !ening$at$an oogenesis dan pertumbuhan 6ollicle dalam

    o#arium

    !engguna$an e6e$ anaboli$ pd saluran reprodu$si %anita

    Aterine tubes, uterus, and #agina tumbuh membesar dan

    menjadi ber6ungsi

    7uba 6allopii dan uterus menunju$$an pening$atan motilitas

    !u$osa #agina menebal dan genetalia e$sternal matang

    $ek0 trauterine strogens dan Progesterone

    Tanda1tanda 2elamin #ekunder 3ang %isebab

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    Pertumbuhan payudara

    !ening$atnya deposisi lema$ sub$utan, $hususnya

     pinggul dan payudara

    Panggul melebar dan menjadi ringan

    Pertumbuhan bulu pubis dan a-ila

    Tanda1tanda 2elamin #ekunder 3ang %isebab

    kan strogen

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    #eually Transmitted %iseases* )onorrhea

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    #eually Transmitted %iseases* )onorrhea

    Bacterial in6ection spread by contact %ith genital,anal, and pharyngeal mucosal sur6aces

    igns and symptoms

    In males pain6ul urination, discharge o6 pus 6rom

    the penis In 6emales none '20(, abdominal discom6ort,

    #aginal discharge, abnormal uterine bleeding

    3e6t untreated, can result in pel#ic in6lammatorydisease

    7reatment* antibiotics, but resistant strains are becoming more pre#alent

    #eually Transmitted %iseases* #yphilis

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    #eually Transmitted %iseases* #yphilis

    Bacterial in6ection transmitted se-ually or

    contracted congenitally

    In6ected 6etuses are stillborn or die shortly a6ter birth

    ; painless chancre appears at the site o6 in6ection

    and disappears in a 6e% %ee$s

    #eually Transmitted %iseases* #yphilis

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    #eually Transmitted %iseases* #yphilis

    econdary syphilis sho%s signs o6 pin$ s$in rash,

    6e#er, and joint pain

    ; latent period 6ollo%s, %hich may progress to

    tertiary syphilis characteri>ed by gummas 'lesions o6

    the C, blood #essels, bones, and s$in(

    7reatment* penicillin

    #eually Transmitted %iseases* .hlamydia

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    #eually Transmitted %iseases* .hlamydia

    !ost common 7= in the A..

    esponsible 6or 20 o6 all diagnosed cases o6

     pel#ic in6lammatory disease

    ymptoms include urethritis penile and #aginaldischarges abdominal, rectal, or testicular pain

     pain6ul intercourse and irregular menses

    Can cause arthritis and urinary tract in6ections inmen, and sterility in %omen

    7reatment is %ith tetracycline

    %evelopment Aspe"ts* Puberty

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    %evelopment Aspe"ts* Puberty

    eproducti#e organs gro% to adult si>e and become

    6unctional

    econdary se- characteristics appear 

    Characteristics o6 puberty

    !ales enlargement o6 the testes and scrotum,

    appearance o6 a-illary and 6acial hair, and gro%th

    o6 the penis

    /emales enlarging o6 the breasts, menarche, and

    dependable o#ulation

    +enopause

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    5

    +enopause

    "#ulasi dan menses berhenti seluruhnya

    7anpa estrogen yang cu$up, organ reprodu$si dan

     payudara menjadi atrophy

    !enga$ibat$an sensiti6 dan depresi

    Pembuluh darah $ulitb mengalami #asodilatasi yg

    intense 'terjadi hot 6lashes(

    7erdi $ehilangan tulang dan menipisnya $ulit

     berangsur