renal pathology, case 4 the patient is a 69-year-old man with a history of hypertension, diabetes...
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![Page 1: Renal Pathology, Case 4 The patient is a 69-year-old man with a history of hypertension, diabetes mellitus, type 2, and coronary artery disease. He has](https://reader036.vdocuments.us/reader036/viewer/2022082411/56649cfa5503460f949cc8fc/html5/thumbnails/1.jpg)
Renal Pathology, Case 4
• The patient is a 69-year-old man with a history of hypertension, diabetes mellitus, type 2, and coronary artery disease. He has known proteinuria and chronic kidney disease. He has no specific complaints.
• BP 150/72; Pulse 60. Heart, lung, and abdominal exams are unremarkable. He has decreased sensation and proprioception of his feet.
• BUN 36 mg/dl• Creatinine 2.7 mg/dl• Hemoglobin A1C 9%
• Urinalysis 3+ protein
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Describe the histologic findingsNodular (Diabetic) GlomerulosclerosisThis microscopic section of a solitary glomerulus reveals a large "nodule" of mesangial sclerosis (large arrow). This is the “Kimmeistiel-Wilson” lesion seen in diabetes. There is also evidence of moderate, diffuse mesangial sclerosis (small arrow).
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Diabetic GlomerulosclerosisThe electron micrograph of the kidney reveals uniform thickening of all capillary basement membranes. Compare to the previous slide of the histology of the diabetic glomerulus
A – Capillary lumenB – RBCC – Basement membraneD – Epithelial cell
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The electromicrograph of the normal kidney reveals three capillaries arranged around the center core of mesangium (asterix). One capillary contains two red blood cells; another capillary contains a neutrophil. The basement membrane is the thin, black line around each capillary. (compare to the basement membrane in diabetic glomerulsclerosis)
A – Foot processesB – RBCC – CapillaryD - Basement membraneE – Neutrophil
Large arrow – Parietal epithelial cell
Small arrow – Visceral epithelial cell