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1 Renal Association Working Group on Tolvaptan in ADPKD

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Renal Association Working Group on Tolvaptan in ADPKD

http://www.nice.org.uk/guidance/TA358

https://www.scottishmedicines.org.uk/SMC_Advice/Advice/1114_15_tolvaptan_Jinarc/tolvaptan_Jinarc

Page 3: Renal Association Working Group on Tolvaptan in ADPKD · Mayo TKV < Single MR/CT Ht-TKV or PROPKD Eligib 30-89 IA-B 750m M a yo 1 C-E TKV >7soml for if 30-89 Repeat MR TKV =

Page 4: Renal Association Working Group on Tolvaptan in ADPKD · Mayo TKV < Single MR/CT Ht-TKV or PROPKD Eligib 30-89 IA-B 750m M a yo 1 C-E TKV >7soml for if 30-89 Repeat MR TKV =

https://clinicaltrials.gov/ct2/show/NCT02160145

http://www.ema.europa.eu/docs/en_GB/document_library/Regulatory_and_procedural_guideline/2015/11/WC500196569.pdf

https://c-path.org/programs/pkd/regulatory-successes/

Page 5: Renal Association Working Group on Tolvaptan in ADPKD · Mayo TKV < Single MR/CT Ht-TKV or PROPKD Eligib 30-89 IA-B 750m M a yo 1 C-E TKV >7soml for if 30-89 Repeat MR TKV =

evidence

Evidence

http://www.niddk.nih.gov/health-information/health-communication-programs/nkdep/lab-evaluation/gfr-calculators/adults-si-unit-ckd-epi/Pages/default.aspx

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risk

http://www.mayo.edu/research/documents/pkd-center-adpkd-classification/doc-20094754?_ga=1.42938278.2046346149.1449053926

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PKD1

PKD2

PKD1

PKD2

Page 8: Renal Association Working Group on Tolvaptan in ADPKD · Mayo TKV < Single MR/CT Ht-TKV or PROPKD Eligib 30-89 IA-B 750m M a yo 1 C-E TKV >7soml for if 30-89 Repeat MR TKV =

Page 9: Renal Association Working Group on Tolvaptan in ADPKD · Mayo TKV < Single MR/CT Ht-TKV or PROPKD Eligib 30-89 IA-B 750m M a yo 1 C-E TKV >7soml for if 30-89 Repeat MR TKV =

Page 10: Renal Association Working Group on Tolvaptan in ADPKD · Mayo TKV < Single MR/CT Ht-TKV or PROPKD Eligib 30-89 IA-B 750m M a yo 1 C-E TKV >7soml for if 30-89 Repeat MR TKV =

Page 11: Renal Association Working Group on Tolvaptan in ADPKD · Mayo TKV < Single MR/CT Ht-TKV or PROPKD Eligib 30-89 IA-B 750m M a yo 1 C-E TKV >7soml for if 30-89 Repeat MR TKV =

Page 12: Renal Association Working Group on Tolvaptan in ADPKD · Mayo TKV < Single MR/CT Ht-TKV or PROPKD Eligib 30-89 IA-B 750m M a yo 1 C-E TKV >7soml for if 30-89 Repeat MR TKV =

Page 13: Renal Association Working Group on Tolvaptan in ADPKD · Mayo TKV < Single MR/CT Ht-TKV or PROPKD Eligib 30-89 IA-B 750m M a yo 1 C-E TKV >7soml for if 30-89 Repeat MR TKV =

Page 14: Renal Association Working Group on Tolvaptan in ADPKD · Mayo TKV < Single MR/CT Ht-TKV or PROPKD Eligib 30-89 IA-B 750m M a yo 1 C-E TKV >7soml for if 30-89 Repeat MR TKV =

Page 15: Renal Association Working Group on Tolvaptan in ADPKD · Mayo TKV < Single MR/CT Ht-TKV or PROPKD Eligib 30-89 IA-B 750m M a yo 1 C-E TKV >7soml for if 30-89 Repeat MR TKV =

Page 16: Renal Association Working Group on Tolvaptan in ADPKD · Mayo TKV < Single MR/CT Ht-TKV or PROPKD Eligib 30-89 IA-B 750m M a yo 1 C-E TKV >7soml for if 30-89 Repeat MR TKV =

Page 17: Renal Association Working Group on Tolvaptan in ADPKD · Mayo TKV < Single MR/CT Ht-TKV or PROPKD Eligib 30-89 IA-B 750m M a yo 1 C-E TKV >7soml for if 30-89 Repeat MR TKV =

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