relationship of dopamine type 2 receptor binding potential with fasting neuroendocrine hormones and...
DESCRIPTION
Study Design Assessed relationships between fasting levels of insulin and leptin, and AG, BMI, and insulin sensitivity index (SI) with the availability of central DA type 2 receptor (D2R) Measured D2R availability using PET and [ 18 F]fallypride in 8 lean and 14 obese females Fasting hormones collected prior to scanning S I determined by modified OGTT Dunn J et al. Diabetes Care 2012;35:TRANSCRIPT
Relationship of Dopamine Type 2 Receptor Binding Potential With Fasting Neuroendocrine
Hormones and Insulin Sensitivity in Human Obesity
Featured Article:
Julia P. Dunn, M.D., M.S., Robert M. Kessler, M.D., Irene D. Feurer, Ph.D., Nora D. Volkow, M.D., Bruce W. Patterson, Ph.D., Mohammad S. Ansari, M.S.,
Rui Li, M.S., Pamela Marks-Shulman, R.D., M.S., Naji N. Abumrad, M.D.
Diabetes Care Volume 35: 1105-1111
May, 2012
Study Objectives
• Midbrain dopamine (DA) neurons, involved with reward and motivation, are modulated by hormones that regulate food intake (insulin, leptin, and acyl ghrelin [AG])
• Hypothesis: These hormones are associated with deficits in DA signaling in obesity
Dunn J et al. Diabetes Care 2012;35:1105-1111
Study Design
• Assessed relationships between fasting levels of insulin and leptin, and AG, BMI, and insulin sensitivity index (SI) with the availability of central DA type 2 receptor (D2R)
• Measured D2R availability using PET and [18F]fallypride in 8 lean and 14 obese females
• Fasting hormones collected prior to scanning • SI determined by modified OGTT
Dunn J et al. Diabetes Care 2012;35:1105-1111
Dunn J et al. Diabetes Care 2012;35:1105-1111
Dunn J et al. Diabetes Care 2012;35:1105-1111
Dunn J et al. Diabetes Care 2012;35:1105-1111
Dunn J et al. Diabetes Care 2012;35:1105-1111
Dunn J et al. Diabetes Care 2012;35:1105-1111
Conclusions
• Findings provide evidence for an association between the neuroendocrine hormones and DA brain signaling in obese females
Dunn J et al. Diabetes Care 2012;35:1105-1111