reimplantation should be preferred · reimplantation should be preferred laurent de kerchove, md,...
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![Page 1: Reimplantation Should Be Preferred · Reimplantation Should Be Preferred Laurent de Kerchove, MD, PhD Cliniques Universitaires St-Luc, IREC, UCL, Brussels, Belgium Reconstruction](https://reader033.vdocuments.us/reader033/viewer/2022042210/5eae66fcd2150c43192a8719/html5/thumbnails/1.jpg)
Reimplantation Should Be Preferred Laurent de Kerchove, MD, PhD
Cliniques Universitaires St-Luc, IREC, UCL, Brussels, Belgium
Reconstruction of the Aortic Valve and Root: A Practical Approach
September 13th-15th, 2017, Homburg/Saar, Germany
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VSRR: At the beginning
Of the “Valve Sparing Root Replacement Era”
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Sir M. Yacoub
VSRR: At the beginning
Prof. T. David
Reimplantation technique (1992) Remodeling technique (1983)
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VSRR: Initial enthusiasm for both techniques (Reimpl – Remod)
Harrefield 1983 . Stanford 1993 .
Lubeck 1993 . • Toronto 1992
Hopkins 1997 . Hannover 1993 .
Brussels 1996
.
Kari F.A. Circ 2013
• Toronto 1992 • Toronto 1992
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VSRR: Why so such hesitation?
Reimplantation Remodeling
• Faster • Less root dissection • Only 1 suture line
• More hemostatic • Annuloplasty
≠
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VSRR: Doubt on Remodeling
Harrefield 1983 . Stanford 1993 .
Lubeck 1993 . • Toronto 1992
Hopkins 1997 . Hannover 1993 .
Brussels 1996
.
1979-1997: 158 patients 1979-1998: 82 Marfans
M.H. Yacoub JTCVS 1998 E.J. Birks. Circ 1999
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VSRR: Doubt on Remodeling
Harrefield 1983 . Stanford 1993 .
Lubeck 1993 . • Toronto 1992
Hopkins 1997 . Hannover 1993 .
Brussels 1996
.
T. David JTCVS 2006
N. de Oliveira JTCVS 2003
1988-2001: 61 Marfans
1988-2005: 220 patients
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VSRR: Doubt on Remodeling
Harrefield 1983 . Stanford 1993 .
Lubeck 1993 . • Toronto 1992
Hopkins 1997 . Hannover 1993 .
Brussels 1996
. .
C. Miller ATS 2007
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VSRR: Doubt on Remodeling
Harrefield 1983 . Lubeck 1993 . • Toronto 1992
Hopkins 1997 . Hannover 1993 .
Brussels 1996
. Stanford 2001 .
N.D. Patel ATS 2008
S.M. Cattaneo
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VSRR: Doubt on Remodeling
Harrefield 1983 . Lubeck 1993 . • Toronto 1992
Hannover 1993 . Brussels 1996
. Stanford 2001 . Hopkins 2002 . Brussels 2001
.
R.G. Leyh
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VSRR: Doubt on Remodeling
Harrefield 1983 . Lubeck 1993 . • Toronto 1992
Stanford 2001 . Hopkins 2002 . Hannover 1993 .
Brussels 2001
.
A.W. Erasmi ATS2007
Reimplantation @5yr
@3yr Remodeling
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VSRR: Lack of annuloplasty in Remodeling
Harrefield 1983 . Lubeck 1993 . • Toronto 1992
Stanford 2001 . Hopkins 2002 . Hannover 1993 .
Brussels 2001
.
Hanke T., Sievers H.J. JTCS 2009: 191 VSRR, 76% TAV 56% Remodeling
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VSRR: While the world was almost bleu and in peace…
. •
. .
. . . .
. . . Homburg 1995 . Paris 1997
Two “irreducible Gallic”
.
.
.
.
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VSRR: The rational for Remodeling ?
. •
. .
. . . .
. . . Homburg 1995 . Paris 1997
R.G. Leyh Circ. 1999 A. Erasmi JTCVS 2005
Snapshot, “close to native AV dynamics” does not mean DURABILITY ! LACK of annuloplasty in remodeling seems influence much more durability !
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VSRR: Lack of annuloplasty in Remodeling
. •
. .
. . . .
. . . Homburg .
Kunihara T., Schäfers H.J. JTCVS 2012
• 430 VSRR, 70% TAV, • 93% Remodeling
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BAV
Navarra E. EJCTS 2013
FF AR >1+
VAJ <30mm
VAJ ≥30mm
p = 0.93
FF AR >1+
TAV
De Kerchove L. EJCTS 2015
B
0 2 4 6 8 100
20
40
60
80
100
VSR VAJ 28mm
VSR VAJ 28mm
p=0.38
Years
%
Pts at riskVAJ 27 88 52 35 18 8 2VAJ >27 56 44 33 18 9 6
A
0 2 4 6 8 100
20
40
60
80
100
SCA VAJ 28mm
SCA VAJ 28mm
p=0.0001
Years
%
Pts at riskVAJ 27 117 92 61 44 23 7VAJ >27 18 13 8 1
VAJ <28mm
VAJ ≥28mm
p = 0.4
VSRR: Annuloplasty in Reimplantation
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VSRR: Longest term results of Reimplantation vs Remodeling
. • Toronto 1992
. .
. . . .
. . . .
T. David JTCVS 2014
1988-2010: 371 patients (296 Reimpl – 75 Remod)
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VSRR: Longest term results of Reimplantation vs Remodeling
. • Toronto 1992
. . Hopkins
. . . .
. . . .
1988-2012: 146 Marfans (121 Reimpl – 25 Remod)
T. David JACC 2015
1988-2012: 146 Marfans (69 Reimpl – 29 Remod)
J. Price JTCVS 2016
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Reimplantation
VSRR: Evolution of the Remodeling technique
H.J. Schäfers 2013 (started 2008)
Suture Annuloplasty
E. Lansac 2006 (started in 2003)
Circumferential external band
But… • Operative time ! • Root dissection ! • AV dynamics ? • Bleeding ? • Improve durability ?
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VSRR: Doubt on the Reimplantation technique
→ Risk of cusp damage and rapid deterioration of the valve !
R.G. Leyh Circ. 1999
Reimplantation
Bissell M. Eur Heart J. 2014
Max valve opening coronary vascularisation “Stress less” opening/closure
Katayama JTCVS 2008
Only very occasionally reported No significant clinical impact
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Reimplantation
Sinus Graft
R. De Paulis 2002
Cardioroot®
Sinus Graft® C. Miller
Stanford Modification
David V
Valsalva®
VSRR: Evolution of the Reimplantation technique
H. Sievers
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VSRR: Why Reimplantation should be preferred
Safe and reproducible, disseminated worldwide
Proven durability up to 15y in TAV, BAV, Marfan and dissection !
One sizing, one device (graft) (≠ Remodeling + annuloplasty)
→ Costs of the procedure !
Ability to modify valve geometry (from asymmetric BAV to 180°symmetric
configuration) (≠ Remodeling ± annuloplasty)
160° 180°
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VSRR: Wathever the technique you choose,…
Brussels Gallic’s Technique
Homburg Gallic’s technique
Paris Gallic’s technique
do a Reimplantation !
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Thank you
Me at diner tonight !
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VSRR: Why Reimplantation should be preferred
But, excellent long term durability can be achieve in Reimplantation only if
Technical pitfalls avoided (sizing, commissure resuspension)
Appropriate cusp management
Aicher D. Circ. 2011 Schäfers HJ. JTCVS 2006
Central Cusp Plication
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VSRR: How to do it ?
Aicher D. Circ. 2011
Schäfers HJ. JTCVS 2006
1/2
El Khoury G.
Central Cusp Plication
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VSRR: How to do it ?
Pethig K. ATS 2002
le Polain JB. JACC Card. Im. 2009
Tips < annulus
Tips > annulus Residual AR Coapt < 4 mm
Residual AR, Coapt >4 mm Tips > annulus, No AR
Cusp Repair!
Cusp Repair!
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TAV • El Khoury 53% Reimplantation
• David ≈ 60% mixte
• Schäfers ≈ 90% Remodeling
VSRR: How to do it ?
BAV • El Khoury 95% Reimplantation
• Schäfers ≈95% Remodeling
• Miller 66% Reimplantation
• Rate of cusp repair in VSRR
70
2010
0
20
40
60
80
100
1 cusp 2 cusps 3 cusps
70
3625
0
20
40
60
80
100
RCC LCC NCC
30
56 57
0
20
40
60
80
100
AR 0-1+ AR 2+ AR 3+
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1. Valve inspection
2. Root dissection
3. Complex cusp repair
4. Graft sizing & proximal suture line
5. Com. reimplantation & distal suture line
6. Residual prolapse repair
7. Coronary reimplantation
VSRR: How to do it ? Brussels Technique
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1. Valve inspection
2. Root dissection
3. Complex cusp repair
4. Graft sizing & proximal suture line
5. Com. reimplantation & distal suture line
6. Residual prolapse repair
7. Coronary reimplantation
VSRR: How to do it ? Brussels Technique
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1. Valve inspection
2. Root dissection
3. Complex cusp repair
4. Graft sizing & proximal suture line
5. Com. reimplantation & distal suture line
6. Residual prolapse repair
7. Coronary reimplantation
VSRR: How to do it ? Brussels Technique
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1. Valve inspection
2. Root dissection
3. Complex cusp repair
4. Graft sizing & proximal suture line
5. Com. reimplantation & distal suture line
6. Residual prolapse repair
7. Coronary reimplantation
VSRR: How to do it ? Brussels Technique
N/L L/R R/N
L/R R/N N/L
STJ
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1. Valve inspection
2. Root dissection
3. Complex cusp repair
4. Graft sizing & proximal suture line
5. Com. attachment & distal suture line
6. Residual prolapse repair
7. Coronary reimplantation
VSRR: How to do it ? Brussels Technique
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1. Valve inspection
2. Root dissection
3. Complex cusp repair
4. Graft sizing & proximal suture line
5. Com. reimplantation & distal suture line
6. Residual prolapse repair
7. Coronary reimplantation
VSRR: How to do it ? Brussels Technique
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Post-repair TEE
VSRR: How to do it ? Brussels Technique
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VSRR: Why and How to do it ?
Conclusions • VSRR is SAFE, DURABLE, EXC. LT. SURVIVAL & FEW VRE (< Bentall)
in TAV, BAV but also Marfan and AAD
with Reimplantation and with Remodeling techniques
Condicio sine qua non ANNULOPLASTY & CUSP REPAIR !
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Reimplantation
• Birks EJ., Yacoub MH. Circulation. 1999
• De Olievera NC., David TE. JTCVS 2003
• Miller DG. JTCVS 2003
• Bethea BT., Cameron D. ATS 2004
• David T. JTCVS 2006
• Erasmi A., Sievers HH. ATS 2007
Suggest better repair durability with
the Reimplantation technique
Remodeling
VSRR: The Litterature
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AV Repair: Leaflet repair in valve sparing surgery
H.J. Schäfers ATS 2002 L. de Kerchove Circ. 2009
Cusp repair = risk factor of reoperation or recurrent AR • E. Lansac EJCTS 2010 (negative impact of cusp repair decrease with experience) • P.P. Urbanski EJCTS 2012
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Valve sparing root replacement
a = STJ
b c
a’ = graft size
b’ c’
Reimplantation Remodeling
Prolapse level ?
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Hospital mortality
• 1% (4/371 pts Reimpl. & Remod.) T. David JTCVS 2014
• 2% (6/747 pts Remodeling) H-J Schäfers EJCTS 2015
• 2% (4777 pts Metanalysis) B. Arabkhani ATS 2015
• 0.3% (1/381 pts Reimplantation) G. El khoury, updated series 2000 – 2015
• 0.7% (1/146 Marfan Reimpl. & remod.) T.David JACC 2015
• 0% (0/98 Marfan Reimpl. & remod.) J. Price JTCVS 2016
VSRR: Why to do it?
1. SAFE !
12% AAD
8% AAD
10% AAD
Elective
6% AAD
4% AAD
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Freedom from Reoperation
VSRR: Why to do it?
Overall 95%@ 18 y
T. David JTCVS 2014
Reimpl. & Remod.
H-J Schafers EJCTS 2015
Remodeling
S. Mastrobuoni STSA 2014
Reimplantation
2. Durable !
Overall 91%@ 15 y Overall 95%@ 12 y
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VSRR: Why to do it rather than Bentall?
B. Arabkhani, JJ. Takkenberg ATS 2015 A. Mookhoek, JJ. Takkenberg ATS 2016
Bentall VSRR
3. Exc. LT. Survival! 4. Few VRE!
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VSRR: How to do it ?
Kari F.A. Circ 2013
David Operations
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Graft Sizing: N/L com height method
= STJ
VSRR: How to do it ? Brussels Way
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AV repair for AR
Normal Root (<45 mm)
Normal VAJ (<26 mm)
Dilated Root (≥45 mm)
Large VAJ (>26 mm)
Subcom. Anpl. VS Reimplantation
Large VAJ (>26 mm) + Modify valve geometry
Ring Annuloplasty
AV repair Aorta/Annuloplasty repair strategy
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Reimplantation
• Birks EJ., Yacoub MH. Circulation. 1999
• De Olievera NC., David TE. JTCVS 2003
• Miller DG. JTCVS 2003
• Bethea BT., Cameron D. ATS 2004
• David T. JTCVS 2006
• Erasmi A., Sievers HH. ATS 2007
Suggest better repair durability with
the Reimplantation technique
Remodeling
VSRR: How to do it?
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Aicher D. Circulation ;123:178-85, 2011
Predictors of AR recurrence Coaptation height
Bierbach B.O. EJTCS 2010
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AV repair: Probability of Cusp Repair in valve sparing surgery
• No AR → low 10 %
→ Moderate 30-50 %
• AR, central jet
→ High ≈ 100 %
• AR, eccentric jet
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Effect of VAJ size on AV repair durability
Kunihara T., Schäfers H.J. JTCS 2012:
• 430 VSRR, 70% TAV, • 93% remodeling
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VSRR: How to do it ?
Hanke T. JTCVS 2009 Kunihara T. JTCVS 2012
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Sir M. Yacoub
VSRR: Outcomes of historical cohort
T. David
1979-1997: 158 patients
89% @10y
85% @15y
1979-1998: 82 Marfans
M.H. Yacoub JTCVS 1998 E.J. Birks. Circ 1999
95% @18y
T. David JTCVS 2014
1988-2010: 371 patients (296 Reimpl – 75 Remod.)
T. David JTCVS 2014 T. David JACC 2016
1988-2012: 146 Marfans (121 Reimpl – 25 Remod.)
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J. Price JTCVS 2016
VSRR: Why to do it in Marfan syndrome ?
Freedom from TE/Bleeding event Survival
Freedom from Reoperation
VSRR 93% @ 10 y
Bentall 92% @ 10 y
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T. David JACC 2015
VSRR: Why to do it in Marfan syndrome ?
Freedom from Reoperation Freedom from AI >2+
5% reop @ 15 y Overall 8% @ 15 y
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Lansac E., EJCTS 2006:
• 87 pts, 95% TAV • 100% Remodeling, 60% with ring annuloplasty • Less early residual or recurrent AI in Remodeling + ring group
Aicher D., JTCS 20013:
• 559 BAV repair • 193 (34%) VAJ suture annuloplasty in patient VAJ >27 mm • Less early residual or recurrent AI in annuloplasty group
VSRR: Remodeling+annuloplasty long term result