regional centers of excellence program in biodefense samuel l. stanley, jr., m.d. director, midwest...
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Regional Centers of Excellence Program in
Biodefense
Samuel L. Stanley, Jr., M.D.
Director, Midwest Regional Center of Excellence in Biodefense and Emerging
Infectious Diseases Research
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What is the threat?
• Biological Weapons – Terrorism
• Access to weaponized agents.
• Simple microbiology “garage laboratory”.
• Complex molecular biology—access to sophisticated equipment, sophisticated know-how.
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Emerging Infectious Diseases
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Biodefense Research Agenda
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NIH/NIAID budgetProgram 2003 funding 2004
funding2005 proposed budget
+ from 2004 level
NIH 27.178b 28.041b 28.805b 794m
NIAID 3.703b 4.3.03b 4.426b 123m
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Research Resources
• Regional Centers of Excellence for Biodefense and Emerging Infectious Diseases Research
• National Biocontainment Laboratories/Regional Biocontainment Laboratories
• Animal Model Development• Biodefense and Emerging Infections Research
Resources Program• Training Programs• Centers of Human Immunology
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NIAID
DMID
RCE/PRCE/NBL/RBL Network Interactions
Regional Centers for ExcellenceIn Biodefense and EmergingInfectious Diseases (RCEs)
National BiocontainmentLaboratories (NBLs)
Regional BiocontainmentLaboratories (RBLs)
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NIAID Biodefense
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The Model
• Interdisciplinary teams• Basic > Translational > Clinical• Flexibility/Self-Eval• Synergy• Local and regional cooperation• National coordination• Parallel, but intersecting tracks –
translational and basic
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NIAID Agenda
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RCE Program
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Midwest Regional Center of Excellence in Biodefense and Emerging Infectious
Diseases ResearchIA
NE
MO
KS
OH
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Direct Support of Research
Emergency ResponseEnhance Regional
ResearchOn Biodefense
Tri-Partite MissionStrategic Projects
Developmental Projects
New Opportunities
Core Facilities
Education
Fellowship Programs Provision of surge capacity
Expertise in vaccine/diagnostics
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How did we apply for our center?
• Read the RFA– Detailed point by point analysis—what are they
actually looking for in one of these Centers– Clear understanding of deadlines– Clear understanding of funding amounts– Contact program officers with specific
questions/clarifications– Attending informational meetings from NIH
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How did we apply for our center?
• Appointed an institutional leader– Time and willingness to serve– Expertise in the proposed area– Senior enough to interact with leaders– Commitment to project—willing to put above
immediate institutional interests
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How did we apply for our center?
• Early assessment of our strengths and weaknesses re: the RFA– Based on national reputation– Funding (Crisp)– Core Resources– Distinguished faculty– Current activity in the area
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How did we apply for our center?• Reached out to outside partners—key
partner first.– Identification of the key person at the partner
institution—science/clinically based, not administratively based.
– Established basis for partnership—money based on merit--creation of SAC
– Came from a position of strength (already plans in place—major institution for the region)
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How did we apply for our center?
• Open/transparent competition among partner institutions—prelim grant submission
• Long meeting of SAC to develop strategic plan• One voice writing for most sections• Attempt to meet all requirements of RFA but
science tailored for peer review• Multiple funding opportunities within grant to
allow involvement of all institutions—something for everyone
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Summary• MRCE—new NIH paradigm to more
rapidly integrate basic and translational research leading to product development.
• Opportunities for research support through Developmental Projects Program.
• Opportunities for education through Clinical Translational Fellowship program
• Opportunities for education through Biosafety Training Program.
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Summary• Read the RFA• Identify a leader• Objective look at strengths and weaknesses• Identification of partners that will enhance the
application• Establishment of rules for funding that will be
seen as reasonable and equitable• Group input into strategic plan• One voice writing where possible• Meet the RFA requirements, but remember peer
review will focus on scientific content.