Regeneration: Evolution,Model Organisms,And Unanswered Questions

Some of Model Organisms Used in Regenerative Biology

BilaterianTriploblast

Sanchez and Tsonis, 2006

Salamanders are to Regeneration as KY is to Basketball, Bourbon, and Thoroughbreds

Limb

Spinal Cord

Salamander Limb Regeneration

Day 14

Day 5

Day 35

Salamander Limb Blastema

Blastema cells remainrestricted

Blastema cells becomemultipotent

Blastema cells are a mixof restricted and multi-potent cells.

Three Models: (Tanaka, 2003)

How is Proximodistal Patterning Achieved?

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are needed to see this picture.

The Ependymal Response

Ependymal response 14 days post amputation (dpa)