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173. Thorstensen K, Romslo I (1993) The transferrin receptor: its dia­gnostic value and its potential as therapeutic target. Scand I Clin Lab Invest 53 [SuppI215]: 113-120

174. Tompson WG (1988) Comparison of tests for diagnosis of iron depletion in pregnancy. Am J Obstet Gynaecol 159: 1132-1134

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Recommended Reading 125

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188. Oxford, March 1996, Consensus conference: Iron Replacement in Dialysis Patients (unpublished)

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Subject Index

Anemias 94 hemolytic 83, 86 hypochromic microcytic macrocytic 80, 81 normocytic 82, 86 renal 92 pernicious 81, 82 sideroachrestic 35, 97 tumor related 27,93

Antibodies 44 monoclonal 44 polyclonal 44

Antigen-antibody reaction 45 Antigen excess 46 Anulocytes 71 Auto-antibodies 37

against intrinsic factor 85 against parietal cells 84 cold antibodies 37 warm antibodies 37

Bilirubin 20, 111 Blood transfusion 76, 79 Bone-marrow diseases 98 Burr cells 29, 89

Cell necroses 80 CRP (C-reactive protein) 80, 104 Cofactors of erythropoiesis 97

Erythropoiesis 15 ineffective 76, 80 co-factors 29, 98

deficiencies 29 physiological 15

Erythropoietin 17, 62, 90 as tumor marker 91, 105 deficiency 103 therapy 103

Erythrocytes 15 degradation 17, 19 maturation 15 morphology 31

Ferritin 10, 13,47 apoferritin 10 isoferritins (acidic, basic) 10 organ-specific 12 structure 11

Ferritin concentration decreased 68 increased, non-representative

80 increased, representative 76, 77 merits, according to Mazza 63

Ferritin, determinations automation 49,67 reference range 51

Ferro Zine Method 39 Folic acid 29, 57, 60, 98

absorption test 84 deficiency 29, 81 requirement reference range 61 therapy 106

128 Subject Index

Frankfurt, Consesus Conference, January 1996 104

Haptoglobin 35, 55 Heidelberger and Kendall curve

46 Hematological Diagnosis 94, 96 Heme Iron 13 Hemochromatosis 77

idiopathic 79 primary, hereditary 78 secondary, acquired 79

Hemoglobin 17, 20, 66 degradation 20 free 36 HbAo, A2, Hb Bart's 17,30 HbF, HbH, HbS 17,31 synthesis 17

Hemoglobinopathies 30 Hemolysis 35, 36

auto-immune 38 corpuscular 37 extracorpuscular 37 intravascular 37 mechanical 37 toxic 38

Hemopexin 57 Hemosiderin 10, 12, 69 Hepatocytes 2, 11 Hypermenorrhea 72

Immunoassay methods 44 direct 45 indirect 45

Immunoassays 45 enzyme 45, 59 fluorescence 45 latex immunoagglutination 45 luminescent 45,49,60 nephelometric 45 radial immunodiffusion 45 turbidimetric 45, 56

Iron 39 active iron 64 day-to-day fluctuations 42 depot iron 64 Transport iron 5

Iron binding capacity (TIBC) 5,43 Iron determination 39 in bone marrow aspirate 68

determination without 39 with deproteinization 40

reference range 42 Iron deficiency 22, 70, 72

latent 70 manifest 70 pre latent 70 blood donation 21, 76 breast-feeding 73 competitive athletes 74 growth 22, 74 menstruation 23, 74 pregnancy 23, 74 unbalanced diet 23, 75

Iron distribution in the body 12, 64

Iron fraction in serum 42 Iron metabolism

absorption 64 distribution 64 disturbances 25, 26 losses 15 requirement 12 transport 4, 11

Iron saturation 7 Iron status 65 Iron storage 9 Iron storage proteins 44 Iron transport proteins 44 Iso-electric focusing 12,48

Lead poisoning 30 LDH 87, 82,111

Macrocytes 29,82

Subject Index 129

Malignant neoplasia 80 Myelodysplastic syndromes 105 Myoglobin 66, 68

Oxford, Consensus-Conference, March 1996 1 04

Porphyrias 31, 32

Renal failure 104 Reticulo-endothelia1 system

(RES) 10, 17,79

San Diego Declaration 104, 112 Schilling-Test 84 Sickle cells 37 Sickle cell anemia 32, 34 Spherocytes 32, 37 Spherocytosis 37

Target cells 32 Thalassemia 30 Therapeutic approaches in

anemias 101 Iron deficiency 101 Oral administration 101 Parenteral administration of

iron 102

Erythropoeitin deficiency 103 Renal failure 104 Tumour-induced anemias 105 Vitamin Bl2 deficiency 105 Folic acid deficiency 106 Autologous blood donors 107

Transferrin 5, 52, 96 isotransferrin 51, 52

Transferrin methods 52 clinical interpretation 96 clinical significance 97 reference range 53

Transferrin receptor 7,55,96 Transferrin saturation 7,53,97 Transferrin, TIBC 53 Tumors 93, 105

Uremic anemia 85, 89,92

Vitamin B6 deficiency 31 Vitamin Bl2 29, 57, 58, 98

absorption 8 deficiency 29, 81, 84 reference range 59 requirement 59 therapy 105

Zinc-protoporphyrin 26, 32

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