recent update on neurodevelopmental disorders in children - programme book (2016).pdf · the hong...

The Hong Kong Society of Child Neurology and Developmental Paediatrics

Recent Update on

Neurodevelopmental Disorders in Children

Annual Scientific Meeting 20165 – 6 November 2016 (Saturday - Sunday)

Programme Book


www.hkcndp.org

Welcome Message 1

Council Members and Organizing Committee 2

Faculty Members 3

Scientific Programme 4

Academic Accreditations 5

Synopsis

5 November 2016 (Saturday)Seminar 1: New Perspectives in Neurodevelopmental DisordersNeuroplasticity (Professor Tatia Lee) 6Genetic Evaluation for Intellectual Disabilities (ID) – Clinical Approach and Utilisation of Genetic Testing (Dr. Edgar Hau) 7Brain Connectivity in Epilepsy (Dr. Mario Chak) 8

6 November 2016 (Sunday)Seminar 2: Recent Neurobiological Studies and Clinical ApplicationsAutism Spectrum Disorder (ASD), Microbiota and Genes (Professor Kelly Lai) 9Evidence and Rationale for Changes in Viewing Autism Spectrum Disorder (ASD) and Attention Deficit and Hyperactivity Disorder (ADHD) in DSM5 (Dr. Siu-man Lam) 10The Brain, Language Acquisition and Its Disorders (Professor Patrick Wong) 11

Seminar 3: Recent Evidence-based Psychological InterventionsMindfulness – Clinical Applications in Children (Dr. Herman Lo) 12CBT-CSCA: A Local Validated Social Competence Training Programme for Youth with Autism Spectrum Disorder (ASD) (Dr. Raymond Chan) 13A Five Factor Model to Enhance Resilience under Adversity (Professor Samuel Ho) 14

Past Annual Scientific Meetings 15

Table of Contents

Annual Scientific Meeting 2016

1

Welcome Message

On behalf of the Hong Kong Society of Child Neurology and Developmental Paediatrics (HKCNDP), I would like to extend our warmest welcome and thank you for your participation of the Annual Scientific Meeting (ASM) 2016 on “Recent Update on Neurodevelopmental Disorders in Children”. Since the inauguration of HKCNDP in 1994, this is the twenty-first ASM hosted by our Society. Every time, we invite prominent speakers to talk on recent advancement of one area related to Paediatric Neurology or Developmental Paediatrics. We are a bit more ambitious this time by bringing together many local experts to enlighten us on their works as frontiers in a number of areas in Developmental Paediatrics, from neuroscience research to clinical application. What you are going to hear in these two days are all achievements from local scholars and the innovations mentioned for clinical application are within your reach in Hong Kong. Nevertheless, active participation is most treasured through exchange of ideas and sharing of experiences from all the audience. At the end of this ASM, I hope that you will appreciate the great potentials of both science research and new clinical practices in the arena of neurodevelopment and are being inspired to work for better care in children with neurodevelopmental disorders.

I would like to take this opportunity to thank all the speakers who spend their precious time in the preparation of the lectures and the members of organizing committee, namely Dr. Catherine Lam, Dr. Stephenie Liu, Dr. Jasper Chow, Dr. Mario Chak and Dr. Theresa Wong, as well as MIMS (Hong Kong) for their hard works. Last, but not the least, I would like to express my gratitude to Wyeth (Hong Kong) for their everlasting support to our annual scientific meeting.

I wish you all a fruitful and enjoyable Annual Scientific Meeting 2016!

Dr. Kwing-wan TsuiPresidentThe Hong Kong Society of Child Neurology and Developmental Paediatrics

Annual Scientific Meeting 2016 Recent Update on Neurodevelopmental Disorders in Children

1 2

Welcome Message

On behalf of the Hong Kong Society of Child Neurology and Developmental Paediatrics (HKCNDP), I would like to extend our warmest welcome and thank you for your participation of the Annual Scientific Meeting (ASM) 2016 on “Recent Update on Neurodevelopmental Disorders in Children”. Since the inauguration of HKCNDP in 1994, this is the twenty-first ASM hosted by our Society. Every time, we invite prominent speakers to talk on recent advancement of one area related to Paediatric Neurology or Developmental Paediatrics. We are a bit more ambitious this time by bringing together many local experts to enlighten us on their works as frontiers in a number of areas in Developmental Paediatrics, from neuroscience research to clinical application. What you are going to hear in these two days are all achievements from local scholars and the innovations mentioned for clinical application are within your reach in Hong Kong. Nevertheless, active participation is most treasured through exchange of ideas and sharing of experiences from all the audience. At the end of this ASM, I hope that you will appreciate the great potentials of both science research and new clinical practices in the arena of neurodevelopment and are being inspired to work for better care in children with neurodevelopmental disorders.

I would like to take this opportunity to thank all the speakers who spend their precious time in the preparation of the lectures and the members of organizing committee, namely Dr. Catherine Lam, Dr. Stephenie Liu, Dr. Jasper Chow, Dr. Mario Chak and Dr. Theresa Wong, as well as MIMS (Hong Kong) for their hard works. Last, but not the least, I would like to express my gratitude to Wyeth (Hong Kong) for their everlasting support to our annual scientific meeting.

I wish you all a fruitful and enjoyable Annual Scientific Meeting 2016!

Dr. Kwing-wan TsuiPresidentThe Hong Kong Society of Child Neurology and Developmental Paediatrics

Council Members


(2016 – 2018)

Dr. Kwing-wan Tsui

Dr. Florence Mun-yau Lee

Dr. Stephenie Ka-yee Liu

Dr. Theresa Yee-ling Wong

Dr. Mario Wai-kong Chak Dr. Sophelia Hoi-shan Chan

Dr. Josephine Shuk-ching Chong

Dr. Jasper Chin-pang Chow Dr. Catherine Chi-chin Lam

Dr. Wing-cheong Lee

Dr. Tim Kim-tim Liu

President:

Vice President:

Honorary Secretary:

Honorary Treasurer:

Council Members:

Dr. Mario Wai-kong Chak Dr. Jasper Chin-pang Chow Dr. Catherine Chi-chin LamDr. Stephenie Ka-yee LiuDr. Kwing-wan TsuiDr. Theresa Yee-ling Wong

Dr. Chok-wan Chan

Members:

Immediate Past President:

Organizing Committee

HK-CND-016c programme book v4.indd 1-2 31/10/2016 11:30 AM

Co-opted Council Members:

Annual Scientific Meeting 2016 Recent Update on Neurodevelopmental Disorders in Children

3 4

Faculty MembersName Affiliation

Dr. Mario Chak Associate Consultant, Department of Paediatrics and Adolescent Medicine, Tuen Mun Hospital, Hong Kong

Dr. Chok-wan Chan Specialist in Paediatrics, Private Practice, Hong Kong

Dr. Raymond Chan Consultant, Jockey Club iREACH Social Competence Development Center, Hong Kong

Dr. Edgar Hau Senior Medical and Health Officer, Clinical Genetic Service, Department of Health, Hong Kong

Professor Samuel Ho Professor of Psychology, Department of Applied Social Sciences, City University of Hong Kong, Hong Kong

Professor Kelly Lai Associate Professor (Clinical), Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong

Dr. Catherine Lam Specialist in Developmental-Behavioural Paediatrics, Child Assessment Service, Department of Health, Hong Kong

Dr. Siu-man Lam Chief of Service, Department of Child and Adolescent Psychiatry, Castle Peak Hospital, Hong Kong

Dr. Florence Lee Consultant, Child Assessment Service, Department of Health, Hong Kong

Professor Tatia Lee Head and Chair Professor, Department of Psychology, The University of Hong Kong, Hong Kong

Dr. Tim Liu Consultant, Department of Paediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong

Dr. Herman Lo Assistant Professor, Department of Applied Social Sciences, The Hong Kong Polytechnic University, Hong Kong

Dr. Kwing-wan Tsui Consultant, Department of Paediatrics and Adolescent Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong

Professor Patrick WongDirector, Brain and Mind Institute and Stanley Ho Professor of Cognitive Neuroscience, Department of Linguistics and Modern Languages, The Chinese University of Hong Kong, Hong Kong

Dr. Theresa Wong Specialist in Paediatric Neurology, Private Practice, Hong Kong

Scientific Programme

Time Session

13:30 – 14:00 Registration

14:00 – 17:00 Seminar 1: New Perspectives in Neurodevelopmental Disorders(Chairpersons: Dr. Kwing-wan Tsui and Dr. Theresa Wong)

14:00 – 14:50 Neuroplasticity Professor Tatia Lee Department of Psychology, The University of Hong Kong

14:50 – 15:20 Coffee Break

15:20 – 16:10 Genetic Evaluation for Intellectual Disabilities (ID) – Clinical Approach and Utilisation of Genetic TestingDr. Edgar Hau Clinical Genetic Service, Department of Health

16:10 – 17:00 Brain Connectivity in EpilepsyDr. Mario Chak Department of Paediatrics & Adolescent Medicine, Tuen Mun Hospital

5 Novem

ber 2016 (Saturday)6 N

ovember 2016 (Sunday)

Time Session


10:00 – 13:00 Seminar 2: Recent Neurobiological Studies and Clinical Applications(Chairpersons: Dr. Catherine Lam and Dr. Tim Liu)

10:00 – 10:50 Autism Spectrum Disorder (ASD), Microbiota and GenesProfessor Kelly Lai Department of Psychiatry, The Chinese University of Hong Kong


11:20 – 12:10 Evidence and Rationale for Changes in Viewing Autism Spectrum Disorder (ASD) and Attention Deficit and Hyperactivity Disorder (ADHD) in DSM5Dr. Siu-man Lam Department of Child and Adolescent Psychiatry, Castle Peak Hospital

12:10 – 13:00 The Brain, Language Acquisition and Its DisordersProfessor Patrick Wong Department of Linguistics and Modern Languages, The Chinese University of Hong Kong

13:00 – 14:00 Light Lunch Buffet

HK-CND-016c programme book v4.indd 3-4 31/10/2016 11:30 AM

Recent Update on Neurodevelopmental Disorders in Children

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Time Session


14:00 – 17:00 Seminar 1: New Perspectives in Neurodevelopmental Disorders(Chairpersons: Dr. Kwing-wan Tsui and Dr. Theresa Wong)

14:00 – 14:50 Neuroplasticity Professor Tatia Lee Department of Psychology, The University of Hong Kong


15:20 – 16:10 Genetic Evaluation for Intellectual Disabilities (ID) – Clinical Approach and Utilisation of Genetic TestingDr. Edgar Hau Clinical Genetic Service, Department of Health

16:10 – 17:00 Brain Connectivity in EpilepsyDr. Mario Chak Department of Paediatrics & Adolescent Medicine, Tuen Mun Hospital

5 Novem

ber 2016 (Saturday)6 N

ovember 2016 (Sunday)

Time Session


10:00 – 13:00 Seminar 2: Recent Neurobiological Studies and Clinical Applications(Chairpersons: Dr. Catherine Lam and Dr. Tim Liu)

10:00 – 10:50 Autism Spectrum Disorder (ASD), Microbiota and GenesProfessor Kelly Lai Department of Psychiatry, The Chinese University of Hong Kong


11:20 – 12:10 Evidence and Rationale for Changes in Viewing Autism Spectrum Disorder (ASD) and Attention Deficit and Hyperactivity Disorder (ADHD) in DSM5Dr. Siu-man Lam Department of Child and Adolescent Psychiatry, Castle Peak Hospital

12:10 – 13:00 The Brain, Language Acquisition and Its DisordersProfessor Patrick Wong Department of Linguistics and Modern Languages, The Chinese University of Hong Kong

13:00 – 14:00 Light Lunch Buffet


5

Academic Accreditations

College / Association 5 Nov 6 Nov

Hong Kong College of Family Physicians (Category 5.2) 3 5

Hong Kong College of Paediatricians (Category A) 3 6

Hong Kong College of Physicians 2.5 5

Hong Kong Occupational Therapists Association TBA TBA

Hong Kong Physiotherapy Association 3 5

MCHK Programme 3 5

Time Session

14:00 – 17:00 Seminar 3: Recent Evidence-based Psychological Interventions(Chairpersons: Dr. Chok-wan Chan and Dr. Florence Lee)

14:00 – 14:50 Mindfulness – Clinical Applications in Children Dr. Herman Lo Department of Applied Social Sciences, The Hong Kong Polytechnic University


15:20 – 16:10 CBT-CSCA: A Local Validated Social Competence Training Programme for Youth with Autism Spectrum Disorder (ASD)Dr. Raymond Chan Jockey Club iREACH Social Competence Development Center

16:10 – 17:00 A Five Factor Model to Enhance Resilience under AdversityProfessor Samuel Ho Department of Applied Social Sciences, City University of Hong Kong

6 Novem

ber 2016 (Sunday)



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2016

Seminar 1New Perspectives in Neurodevelopmental Disorders

NeuroplasticityProfessor Tatia LeeHead and Chair Professor, Department of Psychology, The University of Hong Kong, Hong Kong

The brain is a malleable organ. It alters its structure and functions as a result of learning and experience, allowing the individual to become increasingly efficient in coping with the environmental demands encountered. This phenomenon is termed “neuroplasticity”.

During development, the brain is undergoing enormous neuroplastic changes as a result of experiences induced by learning as well as the exposure to endogenous/exogenous life factors. Because of the plastic nature of the brain, the effect of these experiences on the developing brain is critical for determining the ultimate neurobehavioral status of an individual. Loneliness is a subjective experiential state that has significant effects on a developing brain. Feeling lonely can be a normative experience. However, intense feeling of loneliness is a risk factor for developing affective disorders. From our research, we have identified a strong relationship between perceived loneliness and the architecture of the brain. The finding on this relationship, specifically, how the functional brain connectivity and the perception of the social world are related, will be presented in this talk.


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5 Novem

ber 2016


Genetic Evaluation for Intellectual Disabilities (ID) – Clinical Approach and Utilisation of Genetic TestingDr. Edgar HauSenior Medical and Health Officer, Clinical Genetic Service, Department of Health, Hong Kong

Development is one of the most important parameter to assess the health status of children. Developmental delay (DD) and intellectual disability (ID) are clinical terms commonly used to describe those children who are referred with developmental concern. There are wide variations of aetiologic yields when diagnosing the children with DD/ID and genetic syndrome or genomic abnormality is the top category explaining certain proportion of diagnoses. Once diagnosis is substantiated, need for ongoing medical investigations may be reviewed and any significant burden from patients, families and health services may be removed. Clinical geneticists and genetic counsellors can provide parents and family members with genetic counselling on, for example, the recurrence risk, the availability of preimplantation and prenatal diagnosis.

With the advancement of technology, genetic tests can provide more relevant information which is useful in diagnosing patients with DD/ID and in providing explanation of any underlying pathobiology of their diseases. On the same hand, clinical approach can merit further algorithm of genetic testing and can verify reversely the reliability and validity of the results/data generated from genetic testing. An evaluation framework for DD/ID, comprising of six components from both clinical approach and laboratory realm, will be introduced in the presentation. It is to help audience understand the mutual benefits between the clinical approach and utilisation of genetic testing. Although a comprehensive description of every genetic disorders is well beyond the scope of this review, some clinical examples commonly encountered in our genetic counselling clinics are available to illustrate the features of particular genetic disorders.


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Brain Connectivity in EpilepsyDr. Mario ChakAssociate Consultant, Tuen Mun Hospital, Tsing Chung Koon Road, Hong Kong

In recent ten years, there is a switch of understanding of how our brain function from working as different specialised functional zone to nowadays discovery of different functional networks. There is increase evidence showing that large scale networks underlying the core mechanism in epilepsy, from seizure production to cognitive dysfunction. In the coming talk, I would like to take this opportunity to discuss about how functional imaging (resting state-FMRI / EEG-FMRI) provide valuable information to characterise network dysfunction. An illustrate example of patient with Landau Kleffner syndrome will be discussed and show how the functional connectivity help us understand how epilepsy affect cognition and other brain function. I hope the audience enjoy this talk and find it fruitful and informative.


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6 Novem

ber 2016

Seminar 2Recent Neurobiological Studies and Clinical Applications

Autism Spectrum Disorder (ASD), Microbiota and GenesProfessor Kelly LaiAssociate Professor (Clinical), Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong

Autism spectrum disorder (ASD) is a complex neuro-developmental disorder with a wide range of physical and psychiatric co-morbidities. Identification of subgroups has the potential to help clarify and disentangle its heterogenous aetiologies. The co-existence of gastrointestinal (GI) symptoms in a proportion of children with ASD has been put forward as a subgroup marker, and complex gut-brain interactions are thought to contribute to pathogenesis in this group. As a preliminary step towards exploring this connection in the Chinese population, findings from our study which compared the rates of GI problems between Chinese children with ASD and typically developing community controls will be presented. GI symptoms were measured using the Questionnaire on Pediatric Gastrointestinal Symptoms – Rome III Version (QPGS-III). Confounding variables examined included the children’s age, gender, co-morbid psychopathologies, diet, and parental anxiety and depression. Our results were similar to western findings in that Chinese children with ASD were twice as likely to suffer from GI symptoms compared to typically developing children in the community. The types of GI symptoms most commonly reported were constipation, abdominal migraine and aerophagia. We found that ASD diagnosis interacted with levels of emotional symptoms to predict GI symptoms - while the presence of emotional symptoms was associated with an increased rate of GI symptoms in both the ASD and the community groups, the increase was significantly greater for children with ASD than for children without. Our findings indicate that ASD, emotional problems and GI symptoms form a multiplicative relationship and warrant further investigation as a marker of an ASD subtype. The findings will be discussed in the context of gut microbiota and genes.


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Evidence and Rationale for Changes in Viewing Autism Spectrum Disorder (ASD) and Attention Deficit and Hyperactivity Disorder (ADHD) in DSM5Dr. Siu-man LamChief of Service, Department of Child and Adolescent Psychiatry, Castle Peak Hospital, Hong Kong

The most substantive clinical advance in developmental neuropsychiatry during the past few years is the publication of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). However, this fifth revision was also the most controversial in the manual’s history. This lecture will try to review the changes & controversies related to the revision of the diagnostic criteria of autism spectrum disorder, attention deficit hyperactivity disorder and discuss briefly the newly introduced category of social communication disorder, especially concerns over issue of validity, impact on service utilization and clinical practice.


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6 Novem

ber 2016


The Brain, Language Acquisition and Its DisordersProfessor Patrick WongDirector, Brain and Mind Institute and Stanley Ho Professor of Cognitive Neuroscience, Department of Linguistics and Modern Languages, The Chinese University of Hong Kong, Hong Kong

Language and communication permeates all aspects of life. In children, language problems are associated with poorer academic outcomes, increased mental health problems, and lower job prospects in adulthood. It is therefore important to identify language problems early so that early intervention can be provided. However, making a diagnosis of language disorder is by no means straightforward for young children, because of the inherent variability in language development. Because the nervous system subserves language development, a greater understanding of the connection our brain and language may offer an avenue for better diagnosis and prognosis. In this presentation, I will first discuss the contributions of the auditory and frontostriatal pathways in spoken language learning. I will then provide examples of how disruptions of these neural systems may lead to language difficulties. Finally, I will argue that structural and functional variability of these systems may be linked to the tremendous variability in language development and even treatment outcomes.


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2016

Seminar 3Recent Evidence-based Psychological Interventions

Mindfulness – Clinical Applications in Children Dr. Herman LoAssistant Professor, Department of Applied Social Sciences, The Hong Kong Polytechnic University, Hong Kong

Mindfulness is the awareness that arises from paying attention on purpose, in the present moment non-judgmentally in the service of self-understanding, wisdom and compassion. It is originated from a religious and meditative tradition but has been adopted as an intervention approach in health care settings in the last three decades. Mindfulness-based interventions are mostly delivered to help people suffering from chronic diseases and life stress. Participants often report improvements by learning to accept and manage difficulties and challenges, facilitate a better recovery, and experience a positive well-being.

Recently, there is a growing interest in applying mindfulness in children. Different protocols for group- or classroom-based program, such as dot-b, mindful schools, mindfulness matters have been developed and empirical studies in this special area have been accumulating. In this presentation, adaptation of mindfulness exercises according to child developmental stages and challenges will be discussed. Successful implementation of the mindfulness-based intervention to children as well as significant others is another area of concern for practitioners and researchers.

This presentation will include the preliminary results of three randomized control trials in Hong Kong, including mindfulness-based intervention for parents with special needs children, family-based intervention for ADHD children, and for disadvantaged families. Sample experience of mindfulness practice for children and parents will be offered.


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6 Novem

ber 2016


CBT-CSCA: A Local Validated Social Competence Training Programme for Youth with Autism Spectrum Disorder (ASD)Dr. Raymond ChanConsultant, Jockey Club iREACH Social Competence Development Center, Hong Kong

Social impairment is the core deficit of Autism Spectrum Disorder (ASD) (DSM-5, APA, 2013). Systematic and focused intervention addressing this cardinal feature is very limited (Chan, Lo and Tang, 2014). CBT-CSCA has been developed locally with special reference to the Hong Kong contexts as an attempt to address the social training needs of children and adolescents with ASD. The programme has been experimented and evaluated with positive results (Yau et al., 2014). In the past two years, over eighty professionals from various agencies have been trained in using CBT-CSCA. In this lecture, the development, practice and research on CBT-CSCA will be shared and discussed.


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A Five Factor Model to Enhance Resilience under AdversityProfessor Samuel HoProfessor of Psychology, Department of Applied Social Sciences, City University of Hong Kong, Hong Kong

This presentation with discuss a novel model developed by the presenter and his team members to support people to maintain a normal level of functioning under adversity (aka resilience). The model has five components: build a habit to use one’s Strengths regularly, acquire a Hopeful thinking style, cultivate good Interpersonal relationships, take Notice of both positive and negative events, as well as nurture an attitude to Embrace change. These altogether formulate the SHINE model to guide formulation of strategies to enhance resilience. The presentation will first introduce a strength-based intervention program for parents of children with cerebral palsy. The adaptive cognition of hope will be discussed next. A series of hope story books developed in Hong Kong for children from deprived family, parents of children with special needs, individuals recovered from psychiatric illness, and childhood cancer survivors will be introduced. Cognitive theories propose that maladaptive cognitive bias, including attentional bias, memory bias, and interpretation bias, play a key role in psychopathology. A series of studies to examine the role of positive cognitive processing style in psychopathology will be presented. In essence, findings of our on-going research projects suggest that individuals with a tendency to attend to positive stimuli will exhibit less depressive symptoms, even after the effect of anxiety symptoms and negative attentional bias are taken into consideration. Strategies from positive psychology such as gratitude exercises and active constructive response to increase sensitivity to and savoring of positive events will be discussed towards the end of the presentation.


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Since the inauguration of our Society in 1994, Annual Scientific Meetings were held each year:

Past Annual Scientific Meetings

2011

2012

2013

2014

2015

2010

2009

2008

2007

2006

Date: 30 October – 2 November 2015Theme: Paediatric Movement DisordersCourse Director: Professor Donald Gilbert (USA)Keynote Lecture: A Practical Approach to Diagnosis of Common and Rare Movement Disorders

Date: 1 – 3 November 2014Theme: Paediatric NeuropsychopharmacologyCourse Director: Professor Paramala Santosh, United KingdomKeynote Lecture: Collaborative Working between Paediatrics and Child Psychiatry - Service Models and Harnessing Technology for Management of Common Child and Adolescent Mental Health Problems

Date: 2 – 4 November 2013Theme: Paediatric Neurometabolic DisordersCourse Director: Professor Marc Patterson, AustraliaKeynote Lecture: Universal Newborn Screening for Metabolic Disorders

Date: 16 – 19 November 2012Theme: Augmentative and Alternative CommunicationCourse Director: Dr. John Costello, USAKeynote Lecture: Breaking the Silence for Children with Complex Diffculties

Date: 18 – 21 November 2011Theme: Paediatric Neuro-RadiologyCourse Director: Professor Paul Griffiths, UKKeynote Lecture: An Approach to Imaging Children with Cerebral Palsy Date: 26 – 29 November 2010Theme: Neuro-ImmunologyCourse Director: Professor Russell Dale, AustraliaKeynote Lecture: Auto-antibodies in Paediatric Neurology Date: 13 – 16 November 2009Theme: Autism Spectrum Disorders: Updates on ManagementCourse Director: Professor Lonnie Zwaigenbaum, CanadaKeynote Lecture: Complementary and Alternative Medicine in Autism Spectrum Disorders: Public Forum Date: 21 – 24 November 2008Theme: Neuro-GeneticsCourse Director: Professor Alan Percy, USAKeynote Lecture: Exploring the Neurogenetics of Mental Retardation Date: 16 – 19 November 2007Theme: Energy Crisis of Nervous SystemCourse Director: Dr. Ingrid Tein, CanadaKeynote Lecture: Approach to the Diagnosis and Management of Muscle Cramps, Exercise Intolerance and Recurrent Childhood Myoglobinuria Date: 10 – 13 November 2006Theme: Attention Deficit Hyperactivity DisorderCourse Director: Professor Drake Duane, USAKeynote Lecture: Treatment of ADHD: Medical Behavioural and Educational and Prognosis

2002

2000

1999

1998

1997

1996

1995

2003

2005

2004

Date: 11 – 14 November 2005Theme: Neuromuscular Disorders of Infancy, Childhood and AdolescenceCourse Director: Professor Royden Jones, USAKeynote Lecture: Childhood Neuromuscular Disorder from the Perspective of Adult Neurology

Date: 19 – 22 November 2004Theme: Paediatric RehabilitationSpeaker: Dr. Chok-wan ChanKeynote Lecture: Evolution of Developmental Paediatrics in Hong KongCourse Director: Professor Robert Armstrong, CanadaKeynote Lecture: Developmental Paediatrics in the 21st Century

Date: 19 – 22 September 2003Theme: Paediatric Neurocritical CareCourse Director: Dr. Robert Tasker, UKKeynote Lecture: Head Injury and Neuroscience – Inside Fragile Minds

Date: 8 – 11 March 2002Theme: Paediatric Neuro-OphthalmologyCourse Director: Professor David Taylor, UKKeynote Lecture: The Apparently Blind Child

Date: 8 – 11 December 2000Theme: Language Development, Learning Disorders and Brain Plasticity: Research and Clinical ImplicationsCourse Director: Professor Albert Galaburda, USAKeynote Lecture: Language Development, Learning Disorders and Brain Plasticity: Research and Clinical Implications

Date: 20 – 22 November 1999Theme: Paediatric Neuro-EpidemiologyCourse Director: Dr. C. M. Verity, UKKeynote Lecture: What Happens to Children who Suffer with Febrile Convulsions Date: 14 – 16 July 1998Theme: Paediatric EpilepsyCourse Director: Professor Brian Neville, UKKeynote Lecture: Epilepsy: A Potential Reversible Cause of Developmental Disability Date: 11 – 13 November 1997Theme: Neonatal NeurologyCourse Director: Professor Alan Hill, CanadaKeynote Lecture: Brain Injury in Premature Newborn – An Overview Date: 29 October – 1 November 1996Theme: Paediatric NeurorehabilitationCourse Director: Professor Joe Watt, CanadaKeynote Lecture: Recent Advances in Paediatric Neurorehabilitation Date: 14 – 16 November 1995Theme: Neurometabolic DiseasesCourse Director: Professor Kenneth Swaiman, USAKeynote Lecture: Update on Neurometabolic Diseases in Childhood

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