Recent Research Opportunities in the General Surgery Residency Program See the Surgery department’s research websites: Trauma Research Website Cardiothoracic Surgery Research Website Urology Research website Visit Dr. James Wood’s blog (from his trip to Kijabe, Kenya): http://www.kijabemission.blogspot.com/ Research Fellowships: July 1, 2013-June 30, 2015 Lisa Foley, Cardiothoracic, UC Denver Eduardo Gonzalez, Trauma, Denver Health Kenneth Howell, Cardiothoracic, UC Denver Hunter Moore, Trauma, Denver Health, MSCS Alessandro Paniccia, Surgical Oncology, UC Denver Nicole Townsend, Educational Research, Surgery, UC Denver, MSCS Neil Venardos, Cardiothoracic, UC Denver Jeniann Yi, Trauma, Surgical Oncology, Denver Health, MSCS July 1, 2012-June 30, 2014 Shannon Acker, Pediatric Surgery, Children’s Hospital Colorado Daine Bennett, Cardiothoracic, UC Denver, MSCS Kirsten Freeman, Cardiothoracic, UC Denver Camille Stewart, Pediatric Surgery, Children’s Hospital Colorado July 1, 2011-June 30, 2014 Theresa Chin, Trauma, Denver Health July 1, 2011-June 30, 2013 Marshall Bell, Cardiothoracic - UC Denver Karen Lo, Trauma, Surgical Oncology, Denver Health Nicole Nadlonek, Cardiothoracic UC Denver John Stringham, Trauma, Denver Health July 1, 2010-June 30, 2013 Ryan Merkow, American College of Surgeons Fellowship, Chicago, IL July 1, 2010-June 30, 2012 Jeffrey Harr, Trauma Surgery Research Lab Dawn Fevurly, Research, Children’s Hospital, Boston, MA Jessica Yu, Cardiothoracic Surgery Research Lab July 1, 2009-June 30, 2011 Doug Benson, Surgical Oncology Research Lab Joon Lee, Cardiothoracic Surgery Res. Lab Miral Sadaria, Thoracic Surgery Research Lab Phillip Smith, Cardiothoracic Surgery Res. Lab Max Wohlauer, Trauma Surgery Research Lab

July 1, 2008-June 30, 2010 Winston Choi, Trauma Surgery Research Lab John Eun, Trauma Surgery Research Lab James Wood, Pediatric Surgery Research Lab Ann Kulungowski, Research, Children’s Hospital, Boston, MA Jeremy Hedges, MPH Harvard with one year of field Work in Kenya July 1, 2007-June 30, 2009 Traci Kimball, Vascular Surgery Research Lab David Mauchley, Thoracic Surgery Research Lab Franklin Wright, Trauma Surgery Research Lab Erik Peltz, Trauma Surgery Research Lab Taylor Ripley, Oncology Res. Fellowship, NCI July 1, 2006-June 30, 2008 Joel Baumgartner, Surgical Oncology Res. Lab Janeen Jordan, Trauma Surgery Research Lab Jonathan Roach, Pediatric/Trauma Research Lab Carlos Rueda, Vascular Surgery Research Lab

John C. Eun, M.D. Surgical/Trauma Research Fellow 2008-2010 P.I.: Anirban Banerjee, PhD and E.E. Moore, M Areas of research: Causative factors of multi-organ failure (MOF) following trauma/hemorrhagic shock (T/HS). -Primary focus: Determining the role of lipids in post-shock mesenteric lymph to cause acute lung injury/MOF following shock. -Secondary focus: The role of the 5-lipoxygenase pathway in the development of acute lung injury following hemorrhagic shock.

-T/HS model in rats and in mice 3 Abstracts accepted for national meetings-1st author; 1 presented orally, 1 presented as poster,1 oral presentation this October.(Meetings in Fort Meyers, FL; San Antonio, TX. 2 abstracts published in national publications (JSR, Shock). Presentations: Human Post-Shock Mesenteric Lymph Induces a Hypercoagulable State. Quick shot mini-presentation, 4th annual AAS/SUS Academic Surgical Conference. 2/6/2009; Fort Meyers, FL. Postshock Mesenteric Lymph Activates the 5-Lipoxygenase Pathway to Provoke Acute Lung Injury Following Hemorrhagic Shock. Poster presentation, 32nd annual conference on Shock. 6/8/2009; San Antonio, TX. Products of the 5-Lipoxygenase Pathway are Critical for the Development of Acute Lung Injury Following Hemorrhagic Shock. Will be presented at the ACS 95th annual clinical congress surgical forum. 10/12/09; Chicago, IL. Manuscripts: Proteome and System Ontology of Hemorrhagic Shock: Exploring Early Constitutive Changes in Postshock Mesenteric Lymph. Peltz ED, Moore EE, Zurawel AA, Jordan JR, Damle SS, Redzic JS, Masuno T, Eun J, Hansen KC, and Banerjee A. Surgery 2009 Aug;146(2):347-57.

Jeremy Hedges, MD, MPH Research Years: MPH, Field Work July, 2008-June, 2010 Summary of Research Experience Year 1 – Harvard School of Public Health (Boston, Massachusetts) Master of Public Health in Global Health and Population Thesis – “The Political Economy of Emergency and Essential Surgery in Africa” Year 2 – Harvard Traveling Fellow -Tenwek Hospital (Bomet, Kenya) Surgical resident at a rural African hospital covering all surgical specialties. Esophageal cancer research in conjunction with the National Institutes of Health and the National Cancer Institute. Primary endoscopies for esophageal research and the hospital, including diagnostic and interventional.

Photos from Tenwek Hospital, Bomet, Kenya Jeremy Hedges, MD

Jeremy Hedges and James Wood at Tenwek Hospital after Dr. Wood’s 6-week stay at Kijabe, Kenya.

R. Taylor Ripley, MD Surgical Research Fellowship National Cancer Institute 2007-2010

Publications: Ripley RT, Davis JL, Klapper JA, Mathur A, Kammula U, Royal RE, Yang JC, Sherry RM, Hughes MS, Libutti SK, White DE, Steinberg SM, Dudley ME, Rosenberg SA, Avital I. Liver Resection for Metastatic Melanoma with Postoperative Tumor-Infiltrating Lymphocyte Therapy.Ann Surg Oncol. 2009 Sep 24.

Johnson LA, Morgan RA, Dudley ME, Cassard L, Yang JC, Hughes MS, Kammula US, Royal RE, Sherry RM, Wunderlich JR, Lee CC, Restifo NP, Schwarz SL, Cogdill AP, Bishop RJ, Kim H, Brewer CC, Rudy SF, VanWaes C, Davis JL, Mathur A, Ripley RT, Nathan DA, Laurencot CM, Rosenberg SA. Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen.Blood. 2009 Jul 16;114(3):535-46. Epub 2009 May 18. Ripley RT, Cothren CC, Moore EE, Long J, Johnson JL, Haenel JB. Streptococcus milleri infections of the pleural space: operative management predominates. Am J Surg. 2006 Dec;192(6):817-21.

Ripley RT, Cothren CC, Johnson JL, Moore EE.

Hepatic artery avulsion secondary to blunt abdominal trauma.

J Trauma. 2006 Oct;61(4):1022.

Kaikita K, Schoenhard JA, Painter CA, Ripley RT, Brown NJ, Fogo AB, Vaughan DE. Potential roles of plasminogen activator system in coronary vascular remodeling induced by long-term nitric oxide synthase inhibition.

J Mol Cell Cardiol. 2002 Jun;34(6):617-27.

OR Photos, National Cancer Institute

R. Taylor Ripley, MD National Cancer Institute

Ben Eiseman Research Award History Each year the Ben Eiseman Research Awards are presented for the most outstanding work in the basic science and clinical categories. Submissions are open to any first-authored paper that is “in press” or will be published within the current academic year. 1996-97 Basic Science Daniel Meldrum, M.D. (tie) Clinical Joseph Cleveland, M.D. & David Partrick, M.D. 1997-98 Basic Science Daniel Meldrum, M.D. Clinical Carlton Barnett, M.D. 1998-99 Basic Science Craig Selzman, M.D. Clinical Jeffrey Johnson, M.D. 1999-2000 Basic Science Edward Pulido, M.D. Clinical Julie Heimbach, M.D. 2000-01 Basic Science Casey Calkins, M.D. Clinical Thomas Robinson, M.D. 2001-02 Basic Science Christopher Raeburn, M.D. Clinical Christopher Raeburn, M.D. 2002-03 Basic Science Katherine Barsness, M.D. Clinical Casey Calkins, M.D. 2003-04 Basic Science Michael Zimmerman, M.D. Clinical Jason Clarke, M.D. 2004-05 Basic Science Forest Sheppard, M.D. Clinical J. Brent Roaten, M.D. 2005-06 Basic Science J. Brent Roaten, M.D. PhD Clinical Guillermo Escobar, M.D. 2006-07 Basic Science Ashok Babu, M.D Clinical Jonathan Roach, M.D. 2007-08 Basic Science Janeen Jordan, M.D. Clinical Jeff Campsen, M.D. 2008-09 Basic Science Joel Baumgartner, M.D. Clinical Ryan Merkow, M.D. 2009-10 Basic Science David Mauchley, M.D.

Clinical Trevor Nydam, M.D. 2010-2011 Basic Science Max Wohlauer, M.D.

Clinical Science James Wood, M.D. 2011-2012 Basic Science Jeffrey Harr, M.D.

Clinical Science Edward Jones, M.D. 2012-2013 Basic Science Jessica Yu, M.D. Clinical Science Teresa Jones, M.D.

Jessica Yu with Dr. Richard Schulick and Dr. Martin Mc Carter, Eiseman Basic Science Award 2013

Teresa Jones with Dr. Richard Schulick and Dr. Martin Mc Carter, Eiseman Clinical Research Award 2013

Doug Benson – Summary of research for Dr. Carlton Barnett 2010-2011 – Effects of blood transfusion on pancreatic cancer in a murine model,

specifically the effects of gender specific donor transfusion on metastatic events

– Evaluating the tumor microenvironment among transfusion groups – Evaluating sex differences in outcomes – Evaluating inflammatory cell activation and expression in the tumor

microenvironment – Abstracts accepted: – “Gender specific transfusion affects tumor associated

neutrophil:macrophage ratios” presented at the annual Surgical Society of the Alimentary Tract meeting in New Orleans in May 2010

– “Sex-Specific Hormone Concentration In Transfused Stored Erythrocytes”-Presented at the Academic Surgical Conference Feb 2011.

– “Low Dose Blood Transfusion Promotes Pancreatic Cancer Metastases”-Presented at the Academic Surgical Conference Feb 2011.

– “Accumulation of Pro-Cancer Cytokines in the Plasma Fraction of Stored Packed Red Cells”- will be presented at the annual Surgical Society of the Alimentary Tract meeting in Chicago in May 2011

– “Male Sex Predicts Adverse Events and Decreased Survival in Murine Pancreatic Adenocarcinoma”- will be presented at the annual Surgical Society of the Alimentary Tract meeting in Chicago in May 2011

Doug Benson with Dr. Carlton Barnett

Joon Lee with Dr. David Fullerton

Jeff Harr RESEARCH SUMMARY:

• Abstracts: • Harr J, Moore EE, Wohlauer M, Fragoso M, Liang X, Banerjee A, Silliman CC.

Heparin Exacerbates Acute Lung Injury in Animals Subjected to Trauma/Hemorrhagic Shock. (Submitted to 34th Annual Conference on Shock - June 11 - 14, 2011.)

• Wohlauer M, Moore EE, Fragoso M, MD, Harr J, Silliman CC, Hansen KC, Banerjee A. Lymph Influences Postinjury Coagulation. (Submitted to 34th Annual Conference on Shock - June 11 - 14, 2011.) Wohlauer M, Moore EE, Gonzalez E, Harr J, Carr M, Barnett CC, Banerjee A, Silliman CC.Hypercoagulability: The Initial Response to Tissue Injury and Hemorrhagic Shock. (Submitted to 34th Annual Conference on Shock - June 11 - 14, 2011.)

• Harr J, Moore EE, Wohlauer M, Droz N, Fragoso M, Silliman CC, Banerjee A. The Acute Coagulopathy of Trauma is due to Impaired Initial Thrombin Generation but not Clot Formation or Clot Strength. Academic Surgical Congress – February 1-3, 2011.

• Lee L, Kelher M, Moore EE, Silliman CC, Harr J, Benson D, Banerjee A. Hypertonic Saline Inhibits Leukotriene B4 and Arachidonic Acid Priming of the Neutrophil Oxidase. Academic Surgical Congress – February 1-3, 2011.

• Droz N, Wohlauer M, Gonzalez E, Harr J, Fragoso M, Silliman CC, Moore EE. Hemodilution is Not Critical in the Pathogenesis of the Acute Coagulopathy of Trauma. Academic Surgical Congress – February 1-3, 2011.

• Wohlauer M, Fragoso M, Harr J, Silliman CC, Banerjee A, Moore EE. Cross-transfusion of Postshock Mesenteric Lymph Provokes Acute Lung Injury. Academic Surgical Congress – February 1-3, 2011.

• Wohlauer M, Gonzalez E, Harr J, Droz N, Banerjee A Silliman CC, Moore EE. Systemic Heparin Reduces Acute Lung Injury Following Trauma and Hemorrhagic Shock. Academic Surgical Congress – February 1-3, 2011.

Presentations: • Harr J , Moore EE, Wohlauer M, Droz N, Fragoso M, Silliman CC, Banerjee

A. The Acute Coagulopathy of Trauma is due to Impaired Initial Thrombin Generation but not Clot Formation or Clot Strength. Academic Surgical Congress. Feb. 3, 2011.

Manuscripts: • Harr J , Moore EE, Wohlauer M, Droz N, Fragoso M, Silliman CC, Banerjee

A. The Acute Coagulopathy of Trauma is due to Impaired Initial Thrombin Generation but not Clot Formation or Clot Strength. Journal of Surgical Research (Submitted for Publication)

• Harr J , Kounalakis N, Gonzalez R. Merkel Cell Carcinoma: A Clinical Review. Journal of Skin Cancer. (Submitted for Publication)

• Wohlauer M, Gonzalez E, Harr J, Droz, N, Fragoso M, Silliman CC, Moore EE. Hemodilution is Not Critical in the Pathogenesis of the Acute Coagulopathy of Trauma. Journal of Surgical Research. (Submitted for Publication)

• Wohlauer M, Fragoso M, Harr J, Silliman CC, Banerjee A, Moore EE. Cross-transfusion of Postshock Mesenteric Lymph Provokes Acute Lung Injury. Journal of Surgical Research. (Submitted for Publication)

Book Chapters: • Harr J , Stahel P. Hangman’s Fracture. Encyclopedia of Intensive Care

Medicine. (Accepted for Publication)

• Joon Lee • Research Summary, CT Research Lab, 2010-2011 • As Primary investigator: • Investigating the role of pro- and anti-inflammation in the pathogenesis of aortic

stensis. • Evaluating the effects of interleukin-1 beta on aortic valve interstitial cells. • Evaluating the role of oxidized low-density lipoprotein in the pathogenesis of

aortic stenosis. • In collaboration: • Evaluating the tumor microenvironment among transfusion groups. (Doug

Benson) • Physiologic alterations of donor human lungs undergoing ex-vivo lung perfusion.

(Miral Sadaria, Phillip Smith) • Abstracts and Presentations: • ACS 2010: Interleukin-1 beta mediates a phenotypic change in human aortic

valve interstitial cells: Implications for calcific aortic stenosis. JH Lee and DA Fullerton et al.

• Academic Surgial Congress 2011: The p38 mitogen-activated protein kinase mediates osteogenic transformation of human aortic valve interstitial cells by interleukin-1 beta: Implications for aortic stenosis. JH Lee and DA Fullerton et al.

• STS 2011: Cytokine expression profile in human lungs undergoing ex-vivo lung perfusion. MR Sadaria and MJ Weyant et al.

• Publications: • JH Lee, DA Fullerton et al. Stenotic aortic valves have dysfunctional

mechanisms of anti-inflammation: Implications for aortic stenosis. J Thorac Cardiovasc Surg. 2011; 141: 481-486.

• In submission: • JH Lee, DA Fullerton et al. The p38 mitogen activated protein kinase and c-Jun

N-terminal kinase mediate the effects of interleukin-1 beta on human aortic valve interstitial cells: Implications for aortic stenosis. Am J Physiol Heart Circ Physiol. In Submission.

• M Sadaria, MJ Weyant et al. Cytokine expression profile in human lungs undergoing normothermic ex-vivo lung perfusion. Ann Thorac Surg. In Submission

Miral Sadaria with Dr. David Fullerton

Phil Smith with Dr. David Fullerton

Miral Sadaria – Research Summary – Dr. Michael Weyant--Principal Investigator

• – Effects of statin therapy and secretory phospholipase A2 (sPLA2)

inhibition on human esophageal adenocarcinoma cells – Human ex-vivo lung perfusion (EVLP) and cytokine expression during

EVLP – Awaiting IRB approval to start human EVLP clinical trials at our

institution – National Presentations – Inhibition of Secretory Phospholipase A2 Attenuates Expression of

Intercellular Adhesion Molecule-1 in Human Esophageal Adenocarcinoma Cells. Southern Thoracic Surgical Association, November 5, 2010—Oral presentation.

– Cytokine Expression Profile in Human Lungs Undergoing Ex-vivo Lung Perfusion. Society of Thoracic Surgeons, January, 30, 2011—Poster presentation.

– Statins Attenuate Growth and Malignant Potential of Human Esophageal Adenocarcinoma Cells. American Association for Thoracic Surgery, to be presented May 8, 2011 in the C. Walton Lillehei Resident Forum—Oral presentation.

– Publications – Secretory Phospholipase A2 Inhibition Attenuates Intercellular

Adhesion Molecule-1 Expression in Human Esophageal Adenocarcinoma Cells. Miral R. Sadaria, et al. Article in Press.

– Cytokine Expression Profile in Human Lungs Undergoing Normothermic Ex-Vivo Lung Perfusion. Miral R. Sadaria, Phillip D. Smith, et al. Manuscript under review.

Phillip Smith Research Summary- PI: T. Brett Reece Project: Spinal Cord Ischemia and Reperfusion Injury During Aortic Surgery Developed a mouse model of aortic cross-clamping that mimics spinal cord ischemia during aortic surgery. Investigating pharmacologic adjuncts to improve the subsequent reperfusion injury to the spinal cord. PI: Michael J Weyant, T. Brett Reece Project: Ex-Vivo Lung Perfusion Donor lungs that do not meet the criteria for transplantation are put on an ex-vivo perfusion circuit to improve physiologic parameters. Model for experimentation in lung ischemia/reperfusion/inflammation injury and a method to improve marginal donor lungs for transplant into humans

• Max Wohlauer • Wohlauer M,Moore EE, Fragoso M, MD, Harr J, Silliman CC, Hansen KC,

Banerjee A. Lymph Influences Postinjury Coagulation. (Submitted to 34th Annual Conference on Shock - June 11 - 14, 2011.)

• Wohlauer M, Moore EE, MD, EG, Banerjee A, KCH, Silliman CC.The Acute Coagulopathy of Trauma and Pro-inflammatory Toxicity of Stored Blood Are Mediated by Similar Intracellular Proteins. (Submitted to 34th Annual Conference on Shock - June 11 - 14, 2011.)

• Wohlauer M, Moore EE, Gonzalez E, Harr J, Carr M, Barnett CC, Banerjee A, Silliman CC.Hypercoagulability: The Initial Response to Tissue Injury and Hemorrhagic Shock. (Submitted to 34th Annual Conference on Shock - June 11 - 14, 2011.) Abstracts:

• Harr J, Moore EE, Wohlauer M, Fragoso M, Liang X, Banerjee A, Silliman CC. Heparin Exacerbates Acute Lung Injury in Animals Subjected to Trauma/Hemorrhagic Shock. (Submitted to Shock Society)

• Harr J, Moore EE, Wohlauer M, Droz N, Fragoso M, Silliman CC, Banerjee A. The Acute Coagulopathy of Trauma is due to Impaired Initial Thrombin Generation but not Clot Formation or Clot Strength. Academic Surgical Congress 2011.

• Lee L, Kelher M, Moore EE, Silliman CC, Harr J, Benson D, Banerjee A. Hypertonic Saline Inhibits Leukotriene B4 and Arachidonic Acid Priming of the Neutrophil Oxidase. Academic Surgical Congress 2011.

• Droz N, Wohlauer M, Gonzalez E, Harr J, Fragoso M, Silliman CC, Moore EE. Hemodilution is Not Critical in the Pathogenesis of the Acute Coagulopathy of Trauma. Academic Surgical Congress 2011.

• Wohlauer M, Fragoso M, Hrr J, Silliman CC, Banerjee A, Moore EE. Cross-transfusion of Postshock Mesenteric Lymph Provokes Acute Lung Injury. Academic Surgical Congress 2011.

• Wohlauer M, Gonzalez E, Harr J, Droz N, Banerjee A Silliman CC, Moore EE. Systemic Heparin Reduces Acute Lung Injury Following Trauma and Hemorrhagic Shock. Academic Surgical Congress 2011.

• Presentations: • Harr J, Moore EE, Wohlauer M, Droz N, Fragoso M, Silliman CC, Banerjee A.

The Acute Coagulopathy of Trauma is due to Impaired Initial Thrombin Generation but not Clot Formation or Clot Strength. Academic Surgical Congress 2011.

• Manuscripts: • Harr J, Moore EE, Wohlauer M, Droz N, Fragoso M, Silliman CC, Banerjee A.

The Acute Coagulopathy of Trauma is due to Impaired Initial Thrombin Generation but not Clot Formation or Clot Strength. Journal of Surgical Research (Submitted for Publication)

• Harr J, Kounalakis N, Gonzalez R. Merkel Cell Carcinoma: A Clinical Review. Journal of Skin Cancer. (Submitted for Publication)

• Wohlauer M, Gonzalez E, Harr J, Droz, N, Fragoso M, Silliman CC, Moore EE. Hemodilution is Not Critical in the Pathogenesis of the Acute Coagulopathy of Trauma. Journal of Surgical Research. (Submitted for Publication)

• Wohlauer M, Fragoso M, Harr J, Silliman CC, Banerjee A, Moore EE. Cross-transfusion of Postshock Mesenteric Lymph Provokes Acute Lung Injury. Journal of Surgical Research. (Submitted for Publication)

• Book Chapters: • Harr J, Stahel P. Hangman’s Fracture. Encyclopedia of Intensive Care Medicine.

(Accepted for Publication)

Research Summary Jessica Yu PI: Dr. Weyant, CT Surgery Lab Summary of Research, July 2010 – February 2011 Basic Science:

• Investigating mechanisms of lung cancer cell proliferation and invasion in vitro. Developing a mouse model for further study.

• Evaluating blood-based assays for early detection of lung cancer. • Investigating anti-inflammatory mechanisms of ex vivo lung perfusion.

Clinical:

• Evaluating surgical management of inflammatory and infectious lung disease. • Evaluating the use of CT to decrease negative appendectomy and perforation rate

in pregnant patients • Ex vivo lung perfusion

Submissions/Presentations/Publications/Awards (1st author unless noted):

• Lady Windermere revisited: treatment with thoracoscopic lobectomy/segmentectomy for right middle lobe and lingular bronchiectasis associated with non-tuberculous mycobacterial disease.

• -Presented at EACTS Annual Meeting, September 2010 • -Accepted for publication • (co-author) Thoracoscopic lobectomy and segmentectomy for infectious lung

disease • -Presented at STS Annual Meeting, January 2011 • -Submitted for publication • Looking to the Future Scholarship, STS Annual Meeting, January 2011

Max Wohlauer with Dr. Gene Moore & Dr. Anirban Banerjee

2010-2011 Basic Science Dzieciatkowska M, Wohlauer MV, Moore EE, Damle S, Peltz E, Campsen J, Kelher M, Silliman C, Banerjee A, Hansen KC. “Proteomic analysis of human mesenteric Lymph”. Shock. 2011 Apr;35(4):331-8. Published in Shock April 2011, Volume 35, Number 4. By Max Wohlauer, MD (Published with Monika Dzieciatkowska, Ernest (Gene) Moore, Sagar Damle, Erik Peltz, Jeff Campsen, Marguerite Kelher, Christopher Silliman, Anirban Banerjee and Kirk Hansen.) 2010-2011 Clinical Research Wood JH, Partrick DA, Hays T, Sauaia A, Karrer FM, Ziegler MM. “Contemporary pediatric splenectomy: continuing controversies.” Pediatr Surg Int. 2011 May 28. [Epub ahead of print]By James Wood, MD Published in the Journal Pediatric Surgery International and presented at the Western Surgical conference. (Published with David Partrick, Taru Hays, Angela Sauaia, Fritz Karrer and Moritz Ziegler) 2009-2010 Basic Science “Heat Shock protein 27: Induction by gastroduodenal reflux in vivo and augmentation of human esophageal mucosal cell growth in vivo.”Published in The Journal of Thoracic and Cardiovascular Surgery Volume 139, Number 4 By David Mauchley, MD (Published with Xianzhong Meng, MD, PhD, Thomas Johnson, PhD, Jonathan Teitelbaum, Ashok Babu, MD, David A. Fullerton, MD, and Michael J. Weyant, MD ) 2009-2010 Clinical Research “Refractory Postinjury Thrombocytopenia is Associated with Multiple Organ Failure and Adverse Outcomes” By Trevor Nydam, MD Accepted by the Journal of Trauma and presented at the EAST conference (Published with Jeff Johnson, E.E. Moore, Clay Cothren, Carlton Barnett, Walt Biffl, Angela Sauia and Jeff Kashuk)