real-time bone drilling monitoring
DESCRIPTION
TRANSCRIPT
Real-Time Bone Drilling Monitoring
February 2008
2
The Team
Jacob Halevy-Politch, D.Sc., E.E., CEOTechnion–Israel Institute of Technology, Rafael Israel Armaments Development Authority, Israel Air Force
D. Todd Dollinger, ChairmanJetGuide board, The Trendlines Group
Prof. Dan AdamDepartment of Biomedical Engineering, Technion-Israel Institute of Technology
Andrei Craft, D.D.S. Oral and maxillofacial surgeon, formerly Rambam Medical Center (Israel) and Toronto University Dental School
Dr. Nahum Rosenberg, M. Ortho.Orthopedic Department, Rambam Medical Center
Steve RhodesCEO, Misgav Venture Accelerator, and Chairman, The Trendlines Group
3
Blind Man’s Bluff
The Problem Bone drilling: an inexact and, often, blind art. Surgeons risk damaging nerves, blood vessels, and cartilage
Current Solutions CT, panoramic and X-ray imaging pre-surgery; inaccurate manual gauges, and expensive real-time options
The JetGuide Solution
Affordable real-time monitoring with feedback during surgery
4
Vision and Markets
Safe and Accurate Bone Drilling
Orthopedic/spine: >6% growth >$30 billion
Other surgical growth rates up to 15% ENT: ~$5 billion Neurosurgery: spine and skull ~$6 billion Plastic surgery: ~$5 billion
Oral surgery 2 million implants performed annually; $2.4 billion Growth: 15-18% Untapped market: implants 10% of tooth
replacements
5
Value Proposition
Surgeons
Healthcare payors
Real-time intraoperative feedback during surgery builds confidence and raises comfort levels. More surgeons can perform procedures.
Patients
Reduction in complications for decreased costs
Improved outcomes andfaster procedures
6
The JetGuide Dental System
Implantology
Water container
Pump
Transmitter
Switch Receiver
Signal processin
g
DisplayJetGuide
Electronic Unit
JetGuide cellJetGuide ultrasonic
transducer
Dental implant
drill
Drill tip
Water jet stream
Water stream
8
How It Works
Water-Guided Ultrasonic Waves
Bone
Jet stream (water)
Transmitted ultrasonic waves Reflected
ultrasonic wave
Bore
Mandible canal & nerve JetGuide-measured
distance to sensitive tissue
a
9
Competition
CompanySystem price
Disposable price Characteristics
JetGuide $3,500 $30 In development Easy to use, intuitive Follows existing protocols and techniques Real-time intraoperative information
DenX Inc. +$50,000
$500 In advanced development CT images and complicated image
reconstruction Targeting teaching centers and large dental
institutions Reportedly difficult to use
Tactile Technologies
+$15,000
$150 In development Invasive system based on tactile sensing
technology, three-dimensional radiological visualization and miniaturized robotic control
Imadent +$30,000
$300 In development Ultrasound imaging for pre-procedure
planning and real-time monitoring of maxillofacial surgeries
Equipment is bulky and hard to use
Dentosonic Ltd.
$20,000 $100 Development discontinued due to technological obstacles
10
Competitive Advantages
Accurate Real-time Simple to use Safe Affordable Compact
11
Business Development
Target Market First market: maxillofacial and dental surgeons, dental implantologists
Revenue Model Sale of device and per procedure disposables
Marketing Strategy
Reach end-users with established distributors and OEM manufacturers, provide strong support
FDA 510(k) class II
12
Achievements
IP Patents strategy – patents applied for; continuing applications
Technology/Science Operating system, algorithms, display, ultrasound cell
operational Successful experiments on phantoms and ex-vivo fresh
animal bones IRB and Ministry of Health approvals for human trials Clinical trials under way – Rambam Medical Center, Haifa
Business Development Established Scientific Advisory Board On-going talks with leaders in ortho and dental markets
Regulatory FDA pre-ruling received Regulatory strategy, filing in process
Scientific Advisory Committee
Professor Nachum SametAssistant Professor of Restorative Dentistry & Biomaterials Sciences, Harvard School of Dental Medicine
Professor M. SilbermannFormer Chief Scientist, Ministry of Health; Dean, School of Medicine, Technion-Israel Institute of Technology; Chair, Dept. of Anatomy
Professor Peter BirekInternationally recognized expert in dental Implantation and Osseo integration; Dental School, the Univ. of Toronto, Canada.
Professor M. ZaarurChief, Dept. of Neurosurgery, Rambam Hospital; School of Medicine, Technion
Dr. Micha Peled, M.D., D.D.S.Chief, Oral and Maxillofacial Surgery, Rambam Hospital; School of Medicine, Technion-Israel Institute of Technology
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Financial Projections
($000) 2008 2009 2010 2011 2012
Revenues 0 471 5,44716,22
8 29,978
Gross Profit 0 250 3,74611,19
820,37
0
R&D Expenses 287 590 997 1,689 2,855
Sales & Marketing 235 393 703 2,184 3,172
Net Profit (699)(1,030
) 1,505 6,550 13,017
15
Opportunity
JetGuide seeks $2 million for:
Advanced product development Clinical trials Initial production Business development JetGuide Ortho – new markets
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JetGuide Ltd.
Jacob Halevy-Politch, CEOJetGuide Ltd. Telephone: +972. 52.353-7294
E-mail: [email protected]
Web: www.jet-guide.com
Development Plan
2006 2007 2008 2009 20101 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4
Prototype I completed
Proof of concept testing
Prepare business plan, revision
Prototype II development
Seek strategic partners
Prototype III and beta development
FDA, CE-– partial approval for clinical tests
Evaluation in dental clinics
Design, engineering – final product
Establish production process
FDA submission, clearance
Marketing activities
1st sales activities
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About JetGuide
September 2005: joined Misgav Venture Accelerator
Funding to Date
The Office of the Chief Scientist of the Israel Ministry of Industry, Trade & Labor
The Trendlines Israel Fund
Founders