react !!!!!

Choose your own learning partners! - 4 or less people per table- Sit at a regular table, not a lab table

DO NOW: 2 minutes to discuss with your tableA man is returning from Oklahoma by train. He was in a train car where smoking was allowed. If he had been in a non-smoking car, he would have died. WHY?

An Answer:

The man used to be blind -- he's returning from an eye operation which restored his sight. He spent all his money on the operation, so when the train (which had no internal lighting) goes through a tunnel, he thinks he's gone blind again and decides to kill himself. But before he could do it, he saw the light of the cigarettes people were smoking and realized he could still see.

REACT !!!!!

R.E.A.C.T.R espect everyoneE nter and exit appropriatelyA ccept responsibilityC ooperate with everyoneT ake action

Shake hands and state your name to your table partners,

and tell them:a) Today will be greatb) I’m ready to learnc) Thanks in advance for helping

me todayd) Forensics bros 4 life

FIELD TRIP:CSI Exhibit Witte Museum in San Antonio DATE: Friday 1/24 9 AM – 2 PM

COST TO YOU: $5 + lunchHave 1 confirmed parent volunteer

LEARNING OBJECTIVE

CLASSIFY DRUGS ACCORDING TO THE FDA CLASSIFICATION

SYSTEM

I expect you to refrain from talking

or asking about personal experiences

involving drugs.

Is Alex in trouble?

http://www.youtube.com/watch?v=TVodrjz7VRU

http://www.youtube.com/watch?v=TVodrjz7VRU

ANABOLIC STEROIDS

STIMULANTS

LEARNING OBJECTIVE

Identify controlled substances using laboratory procedures such as color test reactions,

chromatography, and spectrophotometry.

METHODS OF DETECTING DRUGS / POISONS

1. Color test2. Chromatography

a. thin-layer chromatography (TLC)b. gas chromatography (GC)c. high performance liquid chromatography (HPLC)

4. Spectroscopy

a. UV light d. X-rayb. visible light e. infrared

c. microwave

Matthew Mathematics, the math teacher at Mammals Middle School, was mysteriously murdered on Monday morning. When Craig Crud, the campus custodian, came to clean the classroom in the morning, he noticed the corpse of Mr. Mathematics and called the cops.

The crime scene team noticed the body of Mr. Mathematics on the floor. They did not find any suspicious items and observed that the body was free of any visible trauma (cuts, bruises, etc).

The crime scene investigators examined the refrigerator in classroom. It contained a pitcher of fruit punch, an opened bottle of CATSUP, a fruit smoothie, and a beaker containing a clear liquid. All of these items were taken to the lab.

YOU WILL PERFORM A COLOR CHANGE TEST TO DETERMINE WHICH SUBSTANCE(s) MAY CONTAIN POISON.

COPY DOWN ON RIGHT PAGE:

Stomach Contents

Fruit Punch

Catsup Fruit Smoothie

Clear Liquid

Color of pH paper

COLOR CHANGE TEST

1) Pipet a small (less than 1 mL) amount of each liquid onto pH paper. 2) Record the color of the pH paper on your chart after ~1 minute.

DISCUSS WITH TABLE PARTNERS: Why did they take those items to the lab?

There were no signs of trauma, so they suspect poisons were involved.

Presumptive Tests for poisons and intoxicants….

Marquis test – opium and derivatives

Duquenois-Levine test – Marijuana (THC)

Van Urk test - LSD

Scott test - Cocaine

Dillie-Koppanyi test – Barbituates

*** These are all color changing tests for detection.

LEFT PAGE REFLECTION

What limitations to you perceive in color change tests?

Would you convict someone just based on a color test? Why or why not?

COLOR TESTS WORK LIKE THIS:1) Mix some chemicals together. 2) Eventually, your mixture will either turn a certain color or not.

COPY DOWN ON RIGHT PAGE:

PAPER CHROMATOGRAPHY:

MARKERS CHOSEN:

What colors did it separate into?

http://www.youtube.com/watch?v=8Sq8k4_YYTQ

Just get it started; we’ll come back to this in about 5 minutes



What is chromatography?From Wikipedia ...

Chromatography (from Greek word for chromos for colour) is the collective term for a family of laboratory techniques for the separation of mixtures. It involves passing a mixture which contains the analyte through a stationary phase, which separates it from other molecules in the mixture and allows it to be isolated.

Which means ...

Chromatography is the physical separation of a mixture into its individual components.

We can use chromatography to separate the components of inks and dyes, such as those found in pens, markers, clothing, and even candy shells. Chromatography can also be used to separate the colored pigments in plants or used to determine the chemical composition of many substances. http://members.shaw.ca/vict/chemistry_test3.htm

Gas ChromatographyUsed to determine the chemical composition of unknown substances, such as the different compounds in gasoline shown by each separate peak in the graph below.

Paper ChromatographyCan be used to separate the components of inks, dyes, plant compounds (chlorophyll), make-up, and many other substances

Liquid ChromatographyUsed to identify unknown plant pigments & other compounds.

Thin-Layer ChromatographyUses thin plastic or glass trays to identify the composition of pigments, chemicals, and other unknown substances.

Examples of Chromatography


PAPER CHROMATOGRAPHY:

MARKERS CHOSEN:

What colors did it separate into?

• Fill in your chart, and explain what happened to the ink on your LEFT PAGE.


What limitations to you perceive in chromatography?

Would you convict someone just based on a chromatography? Why or why not?

27

spectrophotometry• Spectrophotometry (aka spectroscopy) is a

way to identify substances by exposing them to electromagnetic radiation (light)

28

Learning objective

Identify the five classifications of controlled substances

according to to the Controlled Substances Act

29

Drug Control Laws

• There are varying levels and penalties based on manufacture, distribution, possession, or use of a drug, as well as the drug’s weight, type, and concentration

• The Controlled Substances Act – the federal law that establishes five classifications of controlled dangerous substances on the basis of a drug’s potential abuse, potential for physical and psychological dependence, and medical value; the U.S. Attorney General has the authority to add, delete, or reschedule a drug as needed

30

Drug Control Laws (continued)

• Schedule I – High potential for abuse and no currently

accepted medical use in the U.S.– Examples: heroin, marijuana, methaqualone, LSD

31


• Schedule II– High potential for abuse, currently accepted

medical use with severe restrictions, potential for severe physiological and psychological dependence

– Examples: opium and its derivatives, cocaine, methadone, PCP, most amphetamine preparations, most barbiturate preparations, and dronabinol (the synthetic equivalent of marijuana, prescribed for medical use)

32


• Schedule III– Less potential for abuse, currently accepted

medical use, potential for low to moderate physiological and high psychological dependence

– All barbiturates not included in Schedule II, such as codeine preparations and anabolic steroids

33


• Schedule IV– Low potential for abuse, current medical use,

limited dependence related to Schedule III– Examples: tranquilizers

34


• Schedule V– Low abuse, medical use, less potential for

dependence than Schedule IV– Non-narcotic medicinal ingredients and some

opiate drug mixtures

35


• Criminal Penalties Under the Act– The most severe penalties are associated with

Schedule I and II– The Controlled Substance Act controls substances

such as analogs and designer drugs that are chemically similar or related to controlled substances

– Regulates the manufacture and distribution of precursors which are the chemical compounds used by clandestine labs to synthesize drugs

DISCUSS WITH YOUR TABLE:

Why do you think we have drug laws?

react !!!!!

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