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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings About this lecture Composition of Blood Plasma make up and roles Various cell types, origin and roles Red blood cells, hemoglobin & iron metabolism

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Page 1: Rbc

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

About this lectureAbout this lecture

• Composition of Blood

• Plasma make up and roles

• Various cell types, origin and roles

• Red blood cells, hemoglobin & iron metabolism

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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Blood Components: Plasma Transports SolutesBlood Components: Plasma Transports Solutes

• Water, ions, trace elements

• Gasses: O2 & CO2

• Organic Molecules

• Glucose

• N–wastes

• Proteins

• Antibodies

• Hormones

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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Blood Components: Plasma Transports SolutesBlood Components: Plasma Transports Solutes

Figure 16-1: Composition of blood

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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Blood Components: "Blood Count" – % of Each ComponentBlood Components: "Blood Count" – % of Each Component

Figure 16-2: The blood count

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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Blood Components: CellsBlood Components: Cells

• Erythrocytes

• Red Blood Cells (RBC)

• O2 & CO2 transport

• White Blood Cells (WBC)

• Immune defense

• Phagocytosis

• Platelets: clotting

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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Hematopoiesis: Blood Cell FormationHematopoiesis: Blood Cell Formation

• Mostly in bone marrow from stem cells

• Rate regulated by cytokines & growth factors

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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Hematopoiesis: Blood Cell FormationHematopoiesis: Blood Cell Formation

Figure 16-3: Hematopoiesis

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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Focus on RBCs:Focus on RBCs:

Figure 16-5c: Bone marrow

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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Focus on RBCs:Focus on RBCs:

Figure 16-7a, b: Bone marrow

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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Iron Metabolism: Key to Hemoglobin O2 TransportIron Metabolism: Key to Hemoglobin O2 Transport

Figure 16-8: Iron metabolism

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Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Some Diseases of RBCs and O2 TransportSome Diseases of RBCs and O2 Transport

Table 16-3: Causes of Anemia