rationale for identification of carcinogens for the nsf/ul 440 health-based emissions project...
TRANSCRIPT
Draft, Deliberate, and Confidential
Rationale for Identification of Carcinogens for the NSF/UL 440 Health-based Emissions Project
Purpose:
To review the selection criteria for carcinogenic chemicals to be included in the
NSF/UL 440 standard
The comments expressed in this presentation may or may not reflect the views of the CPSC staff as a whole and the Commission
Draft, Deliberate, and Confidential
Step 1 – Identify organizations that have transparent and robust qualitative classifications of chemical carcinogens• Why?
– So that the standard requests analysis of chemicals that are only known as or have a high probability of being a carcinogen
– CA 1350 “Target VOCs” (Section 4.1.2) “include known or probable human carcinogens…”
– CA 1350 draws upon a list of known or probable human carcinogens…” presented in the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65) for some of its “Target VOCs”
• Tier 1 organizations (highest transparency and credible science)– EPA– NTP– IARC
• Tier 2 organizations (lesser transparency/methodological familiarity)– OEHHA proposition 65 listings– NIOSH
Draft, Deliberate, and Confidential
Step 2 – Determine the classifications that have appropriate levels of evidence
• Tier 1
– EPA (http://www.epa.gov/iris/)
• 2005 - Carcinogenic to Humans• 2005 - Likely to be Carcinogenic to Humans• 1999 - Carcinogenic to Humans• 1999 - Likely to be Carcinogenic in Humans• 1996 - Known/Likely Human Carcinogen• 1986 - Group A - (Human Carcinogen)• 1986 - Group B1 - (Probable Human Carcinogen; Limited evidence of carcinogenicity in humans and sufficient
evidence of carcinogenicity in animals)• 1986 - Group B2 - (Probable human carcinogen; Sufficient evidence of carcinogenicity in animals)
– NTP (http://ntp.niehs.nih.gov/?objectid=03C9AF75-E1BF-FF40-DBA9EC0928DF8B15)
• Known to be a Human Carcinogen• Reasonably Anticipated to be Human Carcinogen
– IARC (http://monographs.iarc.fr/ENG/Classification/index.php)
• Group 1 – (Carcinogenic to humans; Sufficient evidence in humans or sufficient evidence in animals and strong mechanistic data in humans)
• Group 2A – (Probably carcinogenic to human; Limited evidence in humans and sufficient evidence in animals)
Draft, Deliberate, and Confidential
Step 2 con’t – Do any other classification systems/organizations have appropriate levels of evidence?
• Tier 2
– OEHHA Proposition 65 list chemicals• “Cancer” • (http://oehha.ca.gov/prop65/prop65_list/files/P65single052413.pdf)
– NIOSH• “Potential Occupational Carcinogen”• (http://www.cdc.gov/niosh/topics/cancer/npotocca.html)
Draft, Deliberate, and Confidential
Step 3 – Compile ALL substances that correspond to these qualitative classifications• EPA (104 substances and chemicals)
– 1986 – Group A - 12, B1 - 5, B2 - 61; – 1996 – 8– 1999 – Carc. to Hum. – 1; Likely – 4– 2005 – Carc. to Hum. – 1; Likely – 12
• NTP (240 substances and chemicals)– Known – 54– Reasonable – 186
• IARC (176 substances and chemicals)– Group 1 – 111– Group 2A – 65
• OEHHA Proposition 65 (554 substances and chemicals)– “Cancer” – 554
• NIOSH (132 substances and chemicals)– “Potential Occupational Carcinogen” - 132
Draft, Deliberate, and Confidential
Step 4 – Remove substances from the lists that are not within scope of NSF/UL 440:
• Biologicals such as bacteria and viruses• Food substances• Exposures to mixtures resultant from food preparation• Particulates• Radionuclides• Complex compositions such as wood smoke, diesel fuel, etc• Occupational chemical exposures• Medications and pharmaceuticals• Metals• Groupings of substances or chemicals without a defined CAS
Draft, Deliberate, and Confidential
Step 5 – Remove substances that are outside the volatility range specified by CA 1350 (0.000227 – 514.1 mm Hg at 25C)CA 1350 defines a VOC as:
Draft, Deliberate, and Confidential
Chemicals Excluded on the Basis of Volatility
Blue = on Al’s list, Green = on HPDB
Chemicals Excluded on the Basis of Volatility
CAS Agency Cancer TRVs (ug/m3)
6-Nitrochrysene 7496-02-8 NTP, IARC yes1,3-Butadiene 106-99-0 EPA 1999, NTP, IARC yesDi(2-ethylhexyl)phthalate (DEHP)
117-81-7 EPA 1986, NTP no
Dibenzo[a,i]pyrene 189-55-9 NTP yesDibenzo[a,h]pyrene 189-64-0 NTP yesDibenzo[a,l]pyrene 191-30-0 NTP, IARC yesDibenzo[a,e]pyrene 192-65-4 NTP yesIndeno[1,2,3-cd ]pyrene 193-39-5 EPA 1986, NTP yes7H-Dibenzo[c,g]carbazole 194-59-2 NTP yesBenzo[j]fluoranthene 205-82-3 NTP yesBenzo[b]fluoranthene 205-99-2 EPA 1986, NTP yesBenzo[k]fluoranthene 207-08-9 EPA 1986, NTP yesChrysene 218-01-9 EPA 1986 yesDibenz[a,h]acridine 226-36-8 NTP, IARC yesDibenz[a,j]acridine 224-42-0 yesHydrazine/Hydrazine sulfate 302-01-2 EPA 1986, NTP yes5-Methylchrysene 3697-24-3 NTP yes1,6-Dinitropyrene 42397-64-8 NTP yes1,8-Dinitropyrene 42397-65-9 NTP yesFormaldehyde 50-00-0 EPA 1986, NTP, IARC yes; 1.3E-05Benzo[a]pyrene (BaP) 50-32-8 EPA 1986, NTP, IARC yes1-Nitropyrene 5522-43-0 NTP, IARC yesBenz[a]anthracene 56-55-3 EPA 1986, NTP yes4-Nitropyrene 57835-92-4 NTP yesChlorinated paraffi ns (C12, 60% chorine)
63449-39-8 NTP no
Vinyl chloride 75-01-4 EPA 1986, EPA 1996, NTP, IARC yesVinyl fluoride 75-02-5 NTP, IARC noAcetaldehyde 75-07-0 EPA 1986, NTP, IARC yes; 2.2E-06Ethylene Oxide 75-21-8 NTP, IARC yesPropylene oxide 75-56-9 EPA 1986, NTP yesBenzidine (and dyes metabolized to benzidine)
92-87-5 EPA 1986, NTP, IARC yes
Dyes metabolized to 3,3'-Dimethylbenzidine
NTP no
Draft, Deliberate, and Confidential
Step 6 – Remove chemicals that:
1) are not on Al Hodgson’s 061212 spreadsheet
2) are not a chemical componentin building products or furnishings listed in the Household Products Database
or 3) do not have a cancer TRV
Draft, Deliberate, and Confidential
Step 7 – Identify the Inhalation Unit Risks for the remaining chemicals
Draft, Deliberate, and Confidential
List of Carcinogenic Chemicals from EPA
• EPA (Tier 1) – 10 out of 104• plus 5 not found in HPDB or as an emission on Al’s spreadsheet
• Blue = on Al’s list, Green = on HPDB
Epichlorohydrin 106-89-8 EPA 1986 2.30E-05; 1.20E-06 OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
1,2-Dibromoethane 106-93-4 EPA 19997.10E-05; 2.20E-04; 0.6 OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf); Health Canada - http://www-
esd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM
Acrylonitrile 107-13-1 EPA 1986 2.90E-04; 6.80E-05 OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
1,4-Dioxane 123-91-1 EPA 2005 7.70E-06 OEHHA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
Chloroprene 126-99-8 EPA 2005 5.00E-04 EPA - http://www.epa.gov/iris/subst/1021.htm; 0<2 yrs - 8.6E-5; 2-16 yrs - 1.8E-4; 16-70 yr - 2.3 E-4
Tetrachloroethylene 127-18-4 EPA 20055.90E-06; 2.60E-07; 2E-06 to 2E-05 OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0106.htm; NAP -
http://www.nap.edu/openbook.php?record_id=12863&page=98
1,3-Dichloropropene 542-75-6 EPA 1986 1.6E-5; 4.0E-6 OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0224.htm
Bis(chloromethyl)ether (BCME)
542-88-1 EPA 19861.3E-02; 6.2E-02; 9.43 OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf); EPA - http://www.epa.gov/iris/subst/0375.htm; Health Canada - http://www-
esd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM
Carbon tetrachloride 56-23-5 EPA 2005 4.2E-05; 1.5E-05; 6E-06 OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA -http://www.epa.gov/iris/subst/0020.htm
Aniline 62-53-3 EPA 1986 1.60E-06 OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf
Benzene 71-43-2EPA 1986, EPA 1996
2.9E-05; 8.3E-06; 2.2E-06 to 7.8E-6; 6E-06OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0276.htm#carc; WHO - http://www.euro.who.int/__data/assets/pdf_file/0009/128169/e94535.pdf
Dichloromethane 75-09-2 EPA 2005 1.0E-08; 2.3E-05 EPA - http://www.epa.gov/iris/subst/0070.htm#carc; Health Canada - http://www-
esd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM
Trichloroethylene 79-01-6 EPA 20052.0E-06; 4.1E-06; 6.1E-04; 4.3E-07 OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0199.htm#carc; Health Canada - http://www-
esd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM; WHO - http://www.euro.who.int/__data/assets/pdf_file/0009/128169/e94535.pdfAcrylamide 79-06-1 EPA 2005 1.3E-03; 1.3E-03; 1E-04 OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0286.htm#carc
1,2,3-Trichloropropane 96-18-4 EPA 2005 NoneNone
List of Chemicals from EPA
Remaining Chemicals
CAS AgencyInhalation Cancer TRVs
(EPA, OEHHA, WHO; HC; WHO; ug/m3)
Citation
Draft, Deliberate, and Confidential
List of Carcinogenic Chemicals from NTP• NTP (Tier 1) – 13 out of 240• plus 5 not found in HPDB or as an emission on Al’s spreadsheet
• Blue = on Al’s list, Green = on HPDB
Styrene 100-42-5 NTP 4.60E-05 OEHHA for styrene oxide, a major metabolite of styrene (http://oehha.ca.gov/risk/pdf/TCDBcas061809.pdf)
1,4-Dichlorobenzene 106-46-7 NTP 1.10E-05 OEHHA (http://oehha.ca.gov/air/hot_spots/pdf/CPFs042909.pdf)
Epichlorohydrin 106-89-8 NTP2.30E-05; 1.20E-06 OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
1,2-Dibromoethane 106-93-4 NTP7.10E-05; 2.20E-04; 0.6 OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf); Health Canada - http://www-
esd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM
Acrylonitrile 107-13-1 NTP 2.90E-04; 6.80E-05 OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
1,4-Dioxane 123-91-1 NTP 7.70E-06 OEHHA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
Chloroprene 126-99-8 NTP 5.00E-04 EPA - http://www.epa.gov/iris/subst/1021.htm; 0<2 yrs - 8.6E-5; 2-16 yrs - 1.8E-4; 16-70 yr - 2.3 E-4
Tetrachloroethylene 127-18-4 NTP5.90E-06; 2.60E-07; 2E-06 to 2E-05 OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0106.htm; NAP -
http://www.nap.edu/openbook.php?record_id=12863&page=98
1,3-Dichloropropene 542-75-6 NTP 1.6E-5; 4.0E-6 OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0224.htm
Bis(chloromethyl)ether (BCME)
542-88-1 NTP1.3E-02; 6.2E-02; 9.43 OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf); EPA - http://www.epa.gov/iris/subst/0375.htm; Health Canada - http://www-
esd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM
Carbon tetrachloride 56-23-5 NTP 4.2E-05; 1.5E-05; 6E-06 OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA -http://www.epa.gov/iris/subst/0020.htm
Thiourea 62-56-6 NTP 2.10E-05 OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf
Benzene 71-43-2 NTP2.9E-05; 8.3E-06; 2.2E-06 to 7.8E-6; 6E-06OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0276.htm#carc; WHO -
http://www.euro.who.int/__data/assets/pdf_file/0009/128169/e94535.pdf
Dichloromethane 75-09-2 NTP 1.0E-08; 2.3E-05 EPA - http://www.epa.gov/iris/subst/0070.htm#carc; Health Canada - http://www-
esd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM
Trichloroethylene 79-01-6 NTP2.0E-06; 4.1E-06; 6.1E-04; 4.3E-07 OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0199.htm#carc; Health Canada - http://www-
esd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM; WHO - http://www.euro.who.int/__data/assets/pdf_file/0009/128169/e94535.pdf
Acrylamide 79-06-1 NTP1.3E-03; 1.3E-03; 1E-04 OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0286.htm#carc
Naphthalene 91-20-3 NTP 3.40E-05 OEHHA - http://oehha.ca.gov/risk/pdf/TCDBcas061809.pdf
1,2,3-Trichloropropane 96-18-4 NTP None None
List of Chemicals from NTP
Remaining Chemicals
CAS AgencyInhalation Cancer TRVs
(EPA, OEHHA, WHO; HC; WHO; ug/m3)
Citation
Draft, Deliberate, and Confidential
List of Carcinogenic Chemicals from IARC
• IARC (Tier 1) – 5 out of 176• plus 2 not found in HPDB or as an emission on Al’s spreadsheet
• Blue = on Al’s list, Green = on HPDB
Epichlorohydrin 106-89-8 IARC2.30E-05; 1.20E-06 OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
Tetrachloroethylene 127-18-4 IARC5.90E-06; 2.60E-07; 2E-06 to 2E-05 OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0106.htm; NAP -
http://www.nap.edu/openbook.php?record_id=12863&page=98Bis(chloromethyl)ether (BCME)
542-88-1 IARC1.3E-02; 6.2E-02; 9.43 OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf); EPA - http://www.epa.gov/iris/subst/0375.htm; Health Canada - http://www-
esd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM
Benzene 71-43-2 IARC2.9E-05; 8.3E-06; 2.2E-06 to 7.8E-6; 6E-06OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0276.htm#carc; WHO -
http://www.euro.who.int/__data/assets/pdf_file/0009/128169/e94535.pdf
Trichloroethylene 79-01-6 IARC2.0E-06; 4.1E-06; 6.1E-04; 4.3E-07 OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0199.htm#carc; Health Canada - http://www-
esd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM; WHO - http://www.euro.who.int/__data/assets/pdf_file/0009/128169/e94535.pdf
Acrylamide 79-06-1 NTP1.3E-03; 1.3E-03; 1E-04 OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0286.htm#carc
1,2,3-Trichloropropane 96-18-4 IARC NoneNone
List of Chemicals from IARC
Remaining Chemicals
CAS AgencyInhalation Cancer TRVs
(EPA, OEHHA, WHO; HC; WHO; ug/m3)
Citation
Draft, Deliberate, and Confidential
Combined List of Chemicals from EPA, NTP, IARC• EPA, NTP, and IARC (Tier 1) – 14 total • plus 5 chemicals not found in HPDB or as an emission on Al’s spreadsheet
• Blue = on Al’s list, Green = on HPDB
Styrene 100-42-5 NTP 4.60E-05 OEHHA for styrene oxide, a major metabolite of styrene (http://oehha.ca.gov/risk/pdf/TCDBcas061809.pdf)
1,4-Dichlorobenzene 106-46-7 NTP 1.10E-05 OEHHA (http://oehha.ca.gov/air/hot_spots/pdf/CPFs042909.pdf)Epichlorohydrin 106-89-8 EPA 1986, NTP, IARC 2.30E-05; 1.20E-06 OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
1,2-Dibromoethane 106-93-4 EPA 1999, NTP7.10E-05; 2.20E-04; 0.6 OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf); Health Canada - http://www-
esd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTMAcrylonitrile 107-13-1 EPA 1986, NTP 2.90E-04; 6.80E-05 OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)1,4-Dioxane 123-91-1 EPA 2005, NTP 7.70E-06 OEHHA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)Chloroprene 126-99-8 EPA 2005, NTP 5.00E-04 EPA - http://www.epa.gov/iris/subst/1021.htm; 0<2 yrs - 8.6E-5; 2-16 yrs - 1.8E-4; 16-70 yr - 2.3 E-4
Tetrachloroethylene 127-18-4 EPA 2005, NTP, IARC5.90E-06; 2.60E-07; 2E-06 to 2E-05 OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0106.htm; NAP -
http://www.nap.edu/openbook.php?record_id=12863&page=981,3-Dichloropropene 542-75-6 EPA 1986, EPA 1996, NTP 1.6E-5; 4.0E-6 OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0224.htmBis(chloromethyl)ether (BCME) 542-88-1 EPA 1986, NTP, IARC 1.3E-02; 6.2E-02; 9.43 OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf); EPA - http://www.epa.gov/iris/subst/0375.htm; Health
Canada - http://www-Carbon tetrachloride 56-23-5 EPA 2005, NTP 4.2E-05; 1.5E-05; 6E-06 OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA -http://www.epa.gov/iris/subst/0020.htm
Aniline 62-53-3 EPA 1986 1.60E-06 OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdfThiourea 62-56-6 NTP 2.10E-05 OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf
Benzene 71-43-2 EPA 1986, EPA 1996, NTP, IARC2.9E-05; 8.3E-06; 2.2E-06 to 7.8E-6; 6E-06 OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0276.htm#carc; WHO -
http://www.euro.who.int/__data/assets/pdf_file/0009/128169/e94535.pdf
Dichloromethane 75-09-2 EPA 2005, NTP 1.0E-08; 2.3E-05 EPA - http://www.epa.gov/iris/subst/0070.htm#carc; Health Canada - http://www-
esd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM
Trichloroethylene 79-01-6 EPA 2005, NTP, IARC
2.0E-06; 4.1E-06; 6.1E-04; 4.3E-07 OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0199.htm#carc; Health Canada - http://www-esd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM; WHO - http://www.euro.who.int/__data/assets/pdf_file/0009/128169/e94535.pdf
Acrylamide 79-06-1 EPA 2005, NTP, IARC 1.3E-03; 1.3E-03; 1E-04 OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0286.htm#carc
Naphthalene 91-20-3 NTP 3.40E-05 OEHHA - http://oehha.ca.gov/risk/pdf/TCDBcas061809.pdf1,2,3-Trichloropropane 96-18-4 EPA 2005, NTP, IARC None None
Citation
Combined List of Chemicals from Tier 1 Agencies or Organizations
Remaining Chemicals CAS AgencyInhalation Cancer TRVs (EPA,
OEHHA, WHO; HC; WHO; ug/m3)
Draft, Deliberate, and Confidential
List of Carcinogenic Chemicals Derived from OEHHA Proposition 65 Listings
(if not already considered in Tier 1 list)
• OEHHA proposition 65 list (Tier 2) – 10 out of 554 – Plus 1 chemical not found in HPDB or as an emission on Al’s spreadsheet– Blue field = found as a product emission on Al’s spreadsheet– Light Green field = found in HPDB– Orange cell = found in HPDB in a product that MAY be associated with building products or furnishings
• NIOSH (Tier 2) – 0 out of 132
Chemicals CAS AgencyCancer TRVs
(ug/m3)Citation
Methyl isobutyl ketone 108-10-1 OEHHA prop 65Ethylbenzene 100-41-4 OEHHA prop 66 2.50E-06 OEHHA (http://oehha.ca.gov/air/hot_spots/pdf/CPFs042909.pdf)Diethanolamine 111-42-2 OEHHA prop 65Benzophenone 119-61-9 OEHHA prop 65Ethyl acrylate 140-88-5 OEHHA prop 65
Hydrazine 302-01-2 OEHHA prop 65 4.9 E-03; 4.9E-03OEHHA (http://oehha.ca.gov/air/hot_spots/pdf/CPFs042909. pdf); http://www.epa.gov/iris/subst/0352.htm
Propylene glycol mono-t -butyl ether 57018-52-7 OEHHA prop 65Coconut oil diethanolamine condensate 68603-42-9 OEHHA prop 65o -Phenylphenol 90-43-7 OEHHA prop 651,3-Dichloro-2-propanol (1,3-DCP) 96-23-1 OEHHA prop 65Cumene (isopropyl benzene) 98-82-8 OEHHA prop 65
List of Chemicals from Tier 2 Agencies or Organizations that haven't been Considered by the Tier 1 Agencies
Draft, Deliberate, and Confidential
Should we include the chemicals from the Tier 2 organizations?
• CA 1350 draws from the Proposition 65 list for some of its target VOCs (“known or probable human carcinogens and reproductive/developmental toxins”)
• Methylisobutyl ketone, ethylbenzene, 1,3 DCP, and isopropyl benzene in Al’s list of chemicals emitted from building products or furnishings
• Diethanolamine and ethylacrylate listed as components in building products (HPDB)
• Benzophenone, benzaldehyde, and cyclohexanone emitted from the UV-cured lacquer of French coated oak parquet flooring (Formation of organic indoor air pollutants by UV-curing chemistry. Salthammer, T.; Bednarek, M.; Fuhrmann, F.; Funaki, R.; Tanabe, S.-I. Journal of Photochemistry and Photobiology A: Chemistry vol. 152 issue 1-3 September 20, 2002. p. 1-9; in addition to the Prop 65 listing, benzaldehyde has some evidence of cancer in mice studies and cancer cluster in Ohio, NTP study of Benzoph. Was done via oral ingestion)
• Propylene glycol mono-t-butyl ether used in water-based paints (Choi et al, 2010), in adhesives, and in water-reducible coatings (NTP, 2004)
• Cocamide diethanolamine primarily used in personal care products (shampoos, hand soaps, and cosmetics), so delete?
• o-polyphenol used primarily as a fungicide or germicide in fruits and vegetables, so delete?
• Hydrazine in rocket and other fuels, not in building products, so delete?
Draft, Deliberate, and Confidential
Final list of 29? Chemicals combiningTier 1, Tier 2, and Aldehydes
(* indicates that a cancer unit risk does not exist)
Styrene 100-42-54.60E-05
OEHHA for styrene oxide, a major metabolite of styrene (http://oehha.ca.gov/risk/pdf/TCDBcas061809.pdf)
1,4-Dichlorobenzene 106-46-7 1.10E-05 OEHHA (http://oehha.ca.gov/air/hot_spots/pdf/CPFs042909.pdf)Epichlorohydrin 106-89-8 2.30E-05; 1.20E-06 OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
1,2-Dibromoethane 106-93-47.10E-05; 2.20E-04; 0.6
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf); Health Canada - http://www-esd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTH
Acrylonitrile 107-13-1 2.90E-04; 6.80E-05 OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)1,4-Dioxane 123-91-1 7.70E-06 OEHHA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
Chloroprene 126-99-85.00E-04
EPA - http://www.epa.gov/iris/subst/1021.htm; 0<2 yrs - 8.6E-5; 2-16 yrs - 1.8E-4; 16-70 yr - 2.3 E-4
Tetrachloroethylene 127-18-45.90E-06; 2.60E-07; 2E-06 to 2E-05
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0106.htm; NAP -
1,3-Dichloropropene 542-75-61.6E-5; 4.0E-6
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0224.htm
Bis(chloromethyl)ether (BCME) 542-88-11.3E-02; 6.2E-02; 9.43
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf); EPA - http://www.epa.gov/iris/subst/0375.htm; Health Canada - http://www-
Carbon tetrachloride 56-23-54.2E-05; 1.5E-05; 6E-06
OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA -http://www.epa.gov/iris/subst/0020.htm
Aniline 62-53-3 1.60E-06 OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdfThiourea 62-56-6 2.10E-05 OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf
Benzene 71-43-22.9E-05; 8.3E-06; 2.2E-06 to 7.8E-6; 6E-06
OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0276.htm#carc; WHO -
Dichloromethane 75-09-21.0E-08; 2.3E-05
EPA - http://www.epa.gov/iris/subst/0070.htm#carc; Health Canada - http://www-esd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTH
Trichloroethylene 79-01-62.0E-06; 4.1E-06; 6.1E-04; 4.3E-07
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0199.htm#carc; Health Canada - http://www-
Acrylamide 79-06-11.3E-03; 1.3E-03; 1E-04
OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0286.htm#carc
Naphthalene 91-20-3 3.4E-05; OEHHA - http://oehha.ca.gov/risk/pdf/TCDBcas061809.pdf1,2,3-Trichloropropane* 96-18-4 . .Methyl isobutyl ketone* 108-10-1 .Ethylbenzene 100-41-4 2.50E-06 OEHHA (http://oehha.ca.gov/air/hot_spots/pdf/CPFs042909.pdf)Diethanolamine* 111-42-2 . .Benzophenone* 119-61-9 . .Ethyl acrylate* 140-88-5 . .Propylene glycol mono-t -butyl ether* 57018-52-7 . .1,3-Dichloro-2-propanol (1,3-DCP)* 96-23-1 . .Cumene (isopropyl benzene)* 98-82-8 . .
Formaldehyde 50-00-0 6E-06; 1.3E-5OEHHA (http://oehha.ca.gov/air/hot_spots/pdf/CPFs042909.pdf); http://www.epa.gov/iris/subst/0419.htm
Acetaldehyde 75-07-0 2.7E-06; 2.2E-06OEHHA (http://oehha.ca.gov/air/hot_spots/pdf/CPFs042909.pdf); http://www.epa.gov/iris/subst/0290.htm
Tier
1Ti
er 2
Extr
a