race, ethnicity, and health disparities · many populations in america, whether defined by race,...
TRANSCRIPT
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Race, Ethnicity, and Health Disparities
Presented by: Delisha Stewart, Ph.DAssistant Professor,Department of NutritionNRI, UNC Chapel Hill
September 19, 2018
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Leading research in precision nutrition by understanding how our genes, the bacteria in our gut, and our environment create differences in our metabolism
that affect our individual requirements for and responses to nutrients.
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Program Insights:
• Factors that are known to contribute to diversity in disease risks
• Differences in disease risks that are related to race and ethnicity
• Modifiable behaviors that reduce risks of developing diseases
• Nutritional interventions that have been shown to diminish disease risks
• Nutritional interventions that have the potential to improve health outcomes
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What are Health Disparities & who experiences them?
Health Disparity PopulationsNIH-designated U.S. health disparity populations include Blacks/African Americans,Hispanics/Latinos, American Indians/Alaska Natives, Asian Americans, NativeHawaiians and other Pacific Islanders, socioeconomically disadvantaged populations,underserved rural populations, and sexual and gender minorities.
Many populations in America, whether defined by race, ethnicity, immigrant status,disability, sex, gender, or geography, experience higher rates of certain diseases andmore deaths and suffering from them compared with the general population.
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Factors associated with diversity of disease risks
RACE & ETHNICITY
GENETICS
ENVIRONMENTAL CONDITIONS / EXPOSURES
IN UTERO EXPOSURE (MOM’S IMPACTING BABY IN WOMB)
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Factors associated with diversity of disease risks
ACCESS
RACE & ETHNICITY
GENETICS
DIET / NUTRITION
ENVIRONMENTAL CONDITIONS / EXPOSURES
ENVIRONMENTAL LIVING CONDITIONS
IN UTERO EXPOSURE (MOM’S IMPACTING BABY IN WOMB)
LIFESTYLE CHOICES (SMOKING, ALCOHOL INTAKE, PHYSICAL ACTIVITY)
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NON-MODIFIABLE MODIFIABLE
Factors associated with diversity of disease risks
ACCESS
RACE & ETHNICITY
GENETICS
DIET / NUTRITION
ENVIRONMENTAL CONDITIONS / EXPOSURES
ENVIRONMENTAL LIVING CONDITIONS
IN UTERO EXPOSURE (MOM’S IMPACTING BABY IN WOMB)
LIFESTYLE CHOICES (SMOKING, ALCOHOL INTAKE, PHYSICAL ACTIVITY)
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Race and Ethnicity-associated disease risk factors (Non-modifiable)
https://www.cdc.gov/nchs/data/hus/hus15.pdf
Figure 18. Life expectancy at birth, by sex, race and Hispanic origin:
United States, 1980–2014.Figure 23. Hypertension among adults aged 20
and over, by sex and race and Hispanic origin:
United States, 1999–2000 through 2013-14.
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Race and Ethnicity-associated disease risk factors (Non-modifiable)
https://ghr.nlm.nih.gov/condition/tay-sachs-disease
• Mutations in the HEXA gene cause Tay-Sachs disease.
• HEXA helps make part of an enzyme calledb-hexosaminidase A, located in lysosomes, which breakdown toxic substances and act as recycling centers.
• Specifically helps break down a fatty substance calledGM2 ganglioside.
Ashkenazi Jews
French-Canadian communities (Quebec)
Old Order Amish community (Pennsylvania)
Cajun population (Louisiana)
Cystic Fibrosis
Mutation in cysticfibrosis transmembraneconductance regulator(CFTR) gene.
NorthEuropean
AfricansAsians
https://www.cff.org/What-is-CF/About-Cystic-Fibrosis/
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Environmental Exposure-associated disease risk factors (Non-modifiable)
Zeger SL, et al. Environ Health Perspect. 2008; 116: 1614-1619.
• Lower socioeconomic position has beenmore consistently associated withgreater harm from air pollution.
• Low socioeconomic status consistentlyincreased the risk of premature deathfrom fine particle pollution among 13.2million Medicare recipients studied inthe largest examination of particlepollution-related mortality nationwide.
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Environmental Living Condition-contributing disease risk factors (Modifiable)
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Diversity in Access-associated disease risk factors (Modifiable)
ACCESS
Fresh Foods
Health
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Access-associated disease risk factors cont. (Modifiable???)
Table 41. Severe headache or migraine, low back pain, and neck pain among adults aged 18 and over, by selected characteristics:United States (1997–2014).
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Race and Ethnicity-associated disease risk factors (Non-modifiable)
•Alcohol-related - 520% greater;
•Tuberculosis - 450% greater;
•Chronic liver disease and cirrhosis - 368% greater;
•Motor Vehicle Crashes - 207% greater;
•Diabetes mellitus - 177% greater;
•Unintentional injuries - 141% greater;
•Poisoning - 118% greater;
•Homicide - 86% greater;
•Suicide - 60% greater;
•Pneumonia and influenza - 37% greater; and
•Firearm injury - 16% greater. https://americanindianhealth.nlm.nih.gov/
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Race and Ethnicity-associated disease risk factors (Non-modifiable)
Wiedman D. 2012, Med Anthropol Q.; 26(4):595-612.
(1)Physical Inactivity
(2)Over-nutrition
(3)Chronic Stress
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Lifestyle Choice-associated disease risk factors (Modifiable)
Low-to-Moderate Alcohol
Consumption
No Use of Tobacco Products
Healthy Nutrition
Regular Physical Activity
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Nutrition – A key modifier to diminish diversity-associated disease risk factors
NOTE: Obesity is defined as a body mass index at or above the sex- and age-specific 95th percentile of the CDC growth charts.SOURCE: CDC/NCHS, Health, United States, 2015, Figure 22. Data from the National Health and Nutrition Examination Survey (NHANES).
Children with obesity, 2011–2014
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Impact of migration on Chinese to the US & Western Diet abroad
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Questions or Comments…
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Metabolic dysfunction & health disparities in cancer research:
BIOMARKERS
Inflammatory signatures
Genomics
Metabolomics
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Metabolic dysfunction & health disparities in cancer research:BIOMARKERSMetabolomics
Inflammatory signatures
Genomics
UNCGILLINGS SCHOOL OF GLOBAL PUBLIC HEALTH
Metabolic profiles in cancer-adjacent
normal breast tissues
Melissa Troester
Characterizing commonalities and differences between the breast and prostate cancer
metabotypes in African Americans
YasminKanaan
ERCMRC Internal
Clinically distinct breast cancer cell lines
have metabolically different responses to
Taxol treatment
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Metabolic profiles in normal breast tissues adjacent to breast tumors Breast Cancer is amulti-faceted disease
Tumor and adjacent tissue microenvironment
Normal myoepithelium
Normal epithelium
Cancer cells
Macrophages
Fibroblast
Blood vessels
Myofibroblast
Stroma
Mesenchymal stem cells
ECM
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cell adhesiondifferentiationcell-cell contact
cell movementinflammationfibrosischemotaxis
Roman-Perez et al., Breast Cancer Res. 2012 14:R51.
Normal tissues express different gene signatures
Luminal A
Reduction
Basal
Luminal B
DCIS
HER2
Reduction Luminal A HER2+DCIS Luminal B Basal-like
Metabolic differences exist in certain normal-adjacent breast tissues
Correlated metabolomic, genomic, and histologic phenotypes in histologically normal breast tissue. X. Sun, D. Stewart, R. Sandhu, et al. (2018), PLOS One.
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Metabolic differences in clinically different breast cancer cell treatment response
TNBC
Luminal A
BT474
MCF7
MDA-MB-468
MDA-MB-231
Usually negative for 3common receptors (TNBC)
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Inflammatory markers also distinguishable across clinically distinct breast cancer cell lines
-100
-50
0
50
100
150
Rel
ativ
e %
Cha
nge
Cytokines
BT474
MCF-7
MDA-MB-231
MDA-MB-468
OPG GRO IL-4 IL-16 IL-6 RANTES
TNBC
Luminal A
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Metabolomics Analysis of Hormone-Responsive and Triple-Negative Breast Cancer Cell Responses to Paclitaxel Identify Key Metabolic Differences. Stewart, et al. (2016), Journal of Proteome Research.
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What Can We Do???
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Higher Dietary Carbohydrates Detrimentally Impact Obesity-Associated Breast Cancer Chemoresistance:
Hypothesis: diets higher in simple carbohydratescontribute to chemoresistance phenotypes in obesity-driven breast cancer more than diets high in fat, but high-carbohydrate and high-fat diets are most detrimental.Diet Groups
A. High Carb
B. High Fat
C. High Carb & Fat
D. Control Diet
Induce Tumor Formation
Indu
ce O
besit
y
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Establish impact of different macronutrients on obesity-induced breast cancer Chemoresistance
Paclitaxel + Doxorubicin + Carboplatin1 wk 1 wk 1 wk
Outcomes Evaluation
Treatment Phase
Sample Collection(obesity)
Sample Collection(tumorigenesis)
Sample Collection(therapy response)
Sample Collection(baseline)
Sample Collection(final outcome)
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Identify nutritionally-associated, obesity-dependent metabolic and inflammatory markers and mechanisms
metabolomics
pathway analysisinflammatory profiling
Which ones are significantly modifiable?
Who do the significantly modifiable markers work for
best?
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Dr. Stephen Hursting
Diet-gene interaction for cancer prevention
Leptin’s Role in Cancer Susceptibility
• Increase in the hormone leptin associated with tumor growth in genetically obese mice.
• Obese people usually have higher leptin & are resistant to its signals.
• Leptin-associated targets may reduce breast cancer susceptibility.
Dr. Steven Zeisel
Choline as an essential nutrient
• We all need choline.
• Men and post-menopausal women need to get choline through their diet.
• Genetics dictate that some pre-menopausal also have to eat choline to get enough.
• Low choline increases birth defects.
Dr. Carol Cheatham
Nutrition for memory and attention abilities
B.E.R.R.Y. Study (Blueberries: Exciting
Research Relevant to You)• Anthocyanins =
an active chemical slows memory loss.
• Only worked in men.(6 mthstudy)
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Acknowledgment of Colleagues, Collaborators and Funding
David H. Murdock Research Institute
Kevin Knagge
Jason Winnike
Huadong Chen
Maria Moreno
Tim Fennell
Rodney Snyder
Scott Watson
Research Triangle Institute, International
Julie Marusich
Ninell Mortensen
Wimal Pathmasiri
Susan McRitchie
Yuanyuan Li
Debby Reed
Stephen Orena
David Kirchner
Susan Sumner
Reza Ghanbari
Eastern Regional Comprehensive Metabolomics Resourse Core
Hossein Maleki
Nutrition Research Institute
Stephen Hursting
JefFrench
Metabolomics Program
FUNDERSFor Good
Health